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DYRK3 Gene

protein-coding   GIFtS: 60
GCID: GC01P206800

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...

  Search for DYRK3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 31 2     DYRK52
Regulatory Erythroid Kinase1 2 3     RED2
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 51 2     Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 32
Protein Kinase Dyrk31 2     hYAK3-22
REDK2 3     EC 2.7.128
EC 2.7.12.13 8     

External Ids:    HGNC: 30941   Entrez Gene: 84442   Ensembl: ENSG000001434797   OMIM: 6034975   UniProtKB: O437813   
ORGUL members:         

Export aliases for DYRK3 gene to outside databases

Previous GC identifers: GC01P205468 GC01P202519 GC01P203452 GC01P203892 GC01P203197 GC01P204875 GC01P177507


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYRK3 Gene:
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation
on serine/threonine and tyrosine residues. The members of this family share structural similarity, however,
differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded
protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and
H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DYRK3 Gene:
DYRK3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
Function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production
during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells.
May act by regulating CREB/CRE signaling

Gene Wiki entry for DYRK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYRK3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYRK3 promoter sequence
   Search Chromatin IP Primers for DYRK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

DYRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206800:  view genomic region     (about GC identifiers)

Start:
206,808,881 bp from pter      End:
206,857,764 bp from pter
Size:
48,884 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 3  
Size: 588 amino acids; 65714 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: D3DT79 Q7Z752 Q9HBY6 Q9HBY7
Alternative splicing: 2 isoforms:  O43781-1   O43781-2   

Explore the universe of human proteins at neXtProt for DYRK3: NX_O43781

Explore proteomics data for DYRK3 at MOPED

Post-translational modifications: 

  • Autophosphorylated on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DYRK3 (O43781) (see all 8)
     GAYIHVP  LYELIKKN  KVIDFGSSC  IGKGSFGQV 


    See DYRK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001004023.1  NP_003573.2  

    ENSEMBL proteins: 
     ENSP00000356076   ENSP00000356075   ENSP00000410187   ENSP00000356073  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
    Dyrk2 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O43781

    ProtoNet protein and cluster: O43781

    UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with DYRK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYRK3_HUMAN, O43781
    Function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production
    during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells.
    May act by regulating CREB/CRE signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: By EPO/erythropoietin

         Genatlas biochemistry entry for DYRK3:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3,expressed in fetal brain,phosphorylating histone
    H2B

         Enzyme Numbers (IUBMB): EC 2.7.12.11 2 EC 2.7.122

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10779429
    GO:0004672protein kinase activity IDA10779429
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with DYRK3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DYRK3:
     Decreased substrate adherent c  Increased HPV18 LCR reporter a  Increased apoptosis 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Dyrk3):
     hematopoietic system 

    Find genes that share phenotypes with DYRK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dyrk3tm1Dowo for DYRK3

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    miRTarBase miRNAs that target DYRK3:
    hsa-mir-26b-5p (MIRT029437)

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    hsa-miR-129-3p hsa-miR-129*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYRK3_HUMAN, O43781: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10779429

    Find genes that share ontologies with DYRK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYRK3
    Interactions:

        Search GeneGlobe Interaction Network for DYRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYRK3 (O437813 ENSP000003560764) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=1 
    LCE2DENSP000003577734STRING: ENSP00000357773
    LCE4AENSP000003352234STRING: ENSP00000335223
    TMCO2ENSP000003618524STRING: ENSP00000361852
    SIRT1ENSP000002120154STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10779429
    GO:0030218erythrocyte differentiation IDA10779429

    Find genes that share ontologies with DYRK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYRK3

    3 HMDB Compounds for DYRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DYRK3 gene (2 alternative transcripts): 
    NM_001004023.1  NM_003582.2  

    Unigene Cluster for DYRK3:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
    Hs.164267  [show with all ESTs]
    Unigene Representative Sequence: AF186774
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367109(uc001hej.3) ENST00000367108(uc001hei.3) ENST00000489878(uc001hek.3)
    ENST00000441486 ENST00000367106
    miRNA
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    hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidDYRK3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF186773.1 AF186774.1 AF327561.1 AK291189.1 AK308082.1 AK313245.1 AY590695.1 BC015501.1 
    BC037269.1 Y12735.2 

    8 DOTS entries:

    DT.99929445  DT.112352  DT.91806904  DT.75187729  DT.100781944  DT.97840209  DT.91717936  DT.100854078 

    Selected AceView cDNA sequences (see all 76):

    CA422249 AF327561 AU149589 BC015501 AI433874 AA609672 BX103376 AA904950 
    CB127400 NM_003582 BP369169 BI827870 AI095264 BX366356 BC037269 AU126055 
    CA308517 NM_001004023 AF186773 CR609403 CD244393 BX426158 CD675887 Y12735 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYRK3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                          -     -                 -                                       
    SP2:                          -     -     -                                                   
    SP3:                                -                 -                                       
    SP4:                                                  -                                       
    SP5:        -     -     -     -     -     -           -                                       


    ECgene alternative splicing isoforms for DYRK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYRK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAGCTTC
    DYRK3 Expression
    About this image


    DYRK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Testis (Reproductive System)
    DYRK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYRK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164267

    UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as
    fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in
    fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node,
    and thymus

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DYRK3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dyrk31 , 5 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 85.32(n)1
    89.93(a)1
      1 (56.90 cM)5
    2264191  NM_145508.21  NP_663483.11 
     1311284415 
    chicken
    (Gallus gallus)
    Aves DYRK31 dual-specificity tyrosine-(Y)-phosphorylation regulated more 71.88(n)
    73.45(a)
      419846  XM_003642723.2  XP_003642771.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYRK36
    dual-specificity tyrosine-(Y)-phosphorylation regu...
    75(a)
    1 ↔ 1
    GL343228.1(1652871-1654421)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dyrk31 dual-specificity tyrosine-(Y)-phosphorylation regulated more 67.02(n)
    69.57(a)
      493520  NM_001008157.1  NP_001008158.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1721801 zgc:172180 63.98(n)
    65.15(a)
      100141364  NM_001114928.1  NP_001108400.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dyrk33 protein serine/threonine kinase 66(a)
    (best of 2)
      102F   --
    worm
    (Caenorhabditis elegans)
    Secernentea mbk-23 serine/threonine kinase (2 domains) 67(a)
    (best of 3)
      IV(13031505-13034122)   --


    ENSEMBL Gene Tree for DYRK3 (if available)
    TreeFam Gene Tree for DYRK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYRK3 gene
    DYRK1A2  DYRK22  HIPK12  ENSG000002729212  DYRK42  HIPK32  HIPK42  HIPK22  
    DYRK1B2  
    4 SIMAP similar genes for DYRK3 using alignment to 3 protein entries:     DYRK3_HUMAN (see all proteins):
    DYRK2    DYRK4    DYRK1B    DYRK1A

    Find genes that share paralogs with DYRK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYRK3 (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809742811,2
    --206807108(+) AAAGGC/TGGCCT 2 -- us2k10--------
    rs75539441,2
    C,F,A,H--206807154(+) GGAACC/GCTTCC 2 -- us2k117Minor allele frequency- G:0.25NA NS EA WA CSA 926
    rs1161182221,2
    C,F--206807198(+) CTGCGG/AATGCA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1465368391,2
    C--206807433(+) CGTAAA/GAGCCC 2 -- us2k10--------
    rs1390977751,2
    C--206807485(+) AGTGGA/GGGAAG 2 -- us2k10--------
    rs1414152991,2
    --206807674(+) GGGACA/GTTTTT 2 -- us2k10--------
    rs727550551,2
    C--206807794(+) TAAGCA/GTTCTA 2 -- us2k10--------
    rs1508164671,2
    --206807840(+) GAACGC/TTTGGT 2 -- us2k10--------
    rs38139651,2
    C,F,H--206807914(-) AAGAAC/TCAGTC 2 -- us2k131Minor allele frequency- T:0.18EA NS NA CSA WA 3888
    rs1908260891,2
    --206808346(+) AAAGTA/CGTCGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYRK3 (206808881 - 206857764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYRK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675844CNV Deletion23128226
    nsv873128CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYRK3
    DNA2.0 Custom Variant and Variant Library Synthesis for DYRK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603497    OMIM disorders: --


    Find genes that share disorders with DYRK3           About GenesLikeMe


    Export disorders for DYRK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYRK3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DYRK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PubMed id 9748265)1, 2, 3 Becker W....Joost H.-G. (J. Biol. Chem. 1998)
    2. REDK, a novel human regulatory erythroid kinase. (PubMed id 10779429)1, 2, 9 Lord K.A....Dillon S.B. (Blood 2000)
    3. Molecular cloning and characterization of novel protein kinase gene DYRK3. (PubMed id 9845759)1, 2 Xia J.... Deng H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1998)
    4. DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. (PubMed id 12356771)1, 9 Li K....Wojchowski D.M. (J. Biol. Chem. 2002)
    5. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. (PubMed id 15607427)1, 9 Zhang D....Wojchowski D.M. (Genomics 2005)
    6. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. (PubMed id 20167603)1, 9 Guo X....Li X. (J. Biol. Chem. 2010)
    7. Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. (PubMed id 23415227)1 Wippich F....Pelkmans L. (Cell 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    10. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). (PubMed id 21693704)1 Huang S.H....Jong A. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8444 HGNC: 3094 AceView: DYRK3 Ensembl:ENSG00000143479 euGenes: HUgn8444
    ECgene: DYRK3 H-InvDB: DYRK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYRK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYRK3 gene:
    Search GeneIP for patents involving DYRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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