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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYRK3 Gene

protein-coding   GIFtS: 57
GCID: GC01P206800

dual-specificity tyrosine-(Y)-phosphorylation regulated...
 Explore 3 diseases affiliated with
DYRK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DYRK3    

Aliases
for DYRK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 31 2     DYRK52
REDK1 2 3     Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 32
RED1 2     Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 52
HYAK3-21     Protein Kinase Dyrk32
Regulatory Erythroid Kinase2 3     EC 2.7.128
EC 2.7.12.13 8     

External Ids:    HGNC: 30941   Entrez Gene: 84442   Ensembl: ENSG000001434797   OMIM: 6034975   UniProtKB: O437813   

Export aliases for DYRK3 gene to outside databases

Previous GC identifers: GC01P205468 GC01P202519 GC01P203452 GC01P203892 GC01P203197 GC01P204875 GC01P177507


Summaries
for DYRK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DYRK3:
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on
serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in
their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has
been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
Function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during
stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by
regulating CREB/CRE signaling

Gene Wiki entry for DYRK3


Genomic Views
for DYRK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYRK3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYRK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYRK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

DYRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206800:  view genomic region     (about GC identifiers)

Start:
 206,808,881 bp from pter      End:
 206,857,764 bp from pter
Size:
 48,884 bases      Orientation:
 plus strand

Proteins
for DYRK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 3  
Size: 588 amino acids; 65714 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Nucleus
Secondary accessions: D3DT79 Q7Z752 Q9HBY6 Q9HBY7
Alternative splicing: 2 isoforms:  O43781-1   O43781-2   

Explore the universe of human proteins at neXtProt for DYRK3: NX_O43781

Post-translational modifications:

  • Autophosphorylated on tyrosine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43781

    • 4/8 DME Specific Peptides for DYRK3 (O43781) (see all 8)
     GAYIHVP  LYELIKKN  KVIDFGSSC  IGKGSFGQV 

    DYRK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001004023.1  NP_003573.2  

    ENSEMBL proteins: 
     ENSP00000356076   ENSP00000356075   ENSP00000410187   ENSP00000356073  

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    Uscn Proteins for DYRK3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10779429


    DYRK3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DYRK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DYRK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O43781

    ProtoNet protein and cluster: O43781

    UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for DYRK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during
    stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by
    regulating CREB/CRE signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: By EPO/erythropoietin

         Genatlas biochemistry entry for DYRK3:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3,expressed in fetal brain,phosphorylating histone H2B

    Enzyme Numbers (IUBMB): EC 2.7.12.11 2 EC 2.7.122

    miRNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10779429
    GO:0004672protein kinase activity IDA10779429
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--


    DYRK3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for DYRK3:
     Decreased substrate adherent c  Increased HPV18 LCR reporter a  Increased apoptosis 

    Animal Models:
         Mouse knock-out Dyrk3tm1Dowo for DYRK3
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Dyrk3):
     hematopoietic system 

    DYRK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DYRK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for DYRK3 (O437813 ENSP000003560764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=1 
    LCE2DENSP000003577734STRING: ENSP00000357773
    LCE4AENSP000003352234STRING: ENSP00000335223
    TMCO2ENSP000003618524STRING: ENSP00000361852
    SIRT1ENSP000002120154STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10779429
    GO:0030218erythrocyte differentiation IDA10779429


    DYRK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DYRK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYRK3

    3 HMDB Compounds for DYRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about DYRK3 

    Transcripts
    for DYRK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DYRK3 gene (2 alternative transcripts): 
    NM_001004023.1  NM_003582.2  

    Unigene Cluster for DYRK3:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
    Hs.164267  [show with all ESTs]
    Unigene Representative Sequence: AF186774
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367109(uc001hej.3) ENST00000367108(uc001hei.3) ENST00000489878(uc001hek.3)
    ENST00000441486 ENST00000367106

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DYRK3:
    hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmid: DYRK3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF186773.1 AF186774.1 AF327561.1 AK291189.1 AK308082.1 AK313245.1 AY590695.1 BC015501.1 
    BC037269.1 Y12735.2 

    7 DOTS entries:

    DT.99929445  DT.112352  DT.91806904  DT.75187729  DT.100781944  DT.97840209  DT.91717936 

    24/76 AceView cDNA sequences (see all 76):

    BI827870 CD675887 BP369169 AF186773 AI095264 CA308517 NM_001004023 AU149589 
    BX426158 Y12735 AA904950 BX366356 CA422249 AA609672 AI433874 AF327561 
    AU126055 CR609403 BX103376 BC015501 CB127400 NM_003582 CD244393 BX101785 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DYRK3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                          -     -                 -                                       
    SP2:                          -     -     -                                                   
    SP3:                                -                 -                                       
    SP4:                                                  -                                       
    SP5:        -     -     -     -     -     -           -                                       


    ECgene alternative splicing isoforms for DYRK3

    Expression
    for DYRK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYRK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGAGCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DYRK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See DYRK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYRK3

    SOURCE GeneReport for Unigene cluster: Hs.164267

    UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal
    liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver
    and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus

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    In Situ
    Assay Products:     
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    Orthologs
    for DYRK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DYRK3 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DYRK31 dual-specificity tyrosine-(Y)-phosphorylation regulated more 71.88(n)
    73.45(a)    		   419846  XM_417975.3  XP_417975.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DYRK36
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343228.1(1652880-1654421)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1721801 zgc:172180 64.1(n)
    65.15(a)    		   100141364  NM_001114928.1  NP_001108400.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dyrk33 protein serine/threonine kinase 66(a)
    (best of 2)    		   102F   --
    worm
    (Caenorhabditis elegans)    		 Secernentea mbk-23 serine/threonine kinase (2 domains) 67(a)
    (best of 3)    		   IV(13031505-13034122)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons YAK16
    		 YAK1-like protein 1
    		 15(a)
    		 possible ortholog
    		 5(14127984-14136324)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 protein kinase, putative, expressed
    		 15(a)
    14(a)
    		 possible ortholog
    possible ortholog
    		 4(30231323-30239025)
    2(28933874-28942548)


    ENSEMBL Gene Tree for DYRK3 (if available)
    TreeFam Gene Tree for DYRK3 (if available) 

    Paralogs
    for DYRK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYRK3 gene
    DYRK22  DYRK1A2  HIPK12  HIPK32  HIPK42  HIPK22  DYRK1B2  DYRK42  
    4 SIMAP similar genes for DYRK3 using alignment to 3 protein entries:     DYRK3_HUMAN (see all proteins):
    DYRK2    DYRK4    DYRK1B    DYRK1A

    DYRK3 for paralogs           About GeneDecksing



    Genomic Variants
    for DYRK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/370 NCBI SNPs in DYRK3 are shown (see all 370)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1809742811,2
    		--206807108(+) AAAGGC/TGGCCT 2 -- us2k10--------
    rs75539441,2
    		C,F,A,H,--206807154(+) GGAACC/GCTTCC 2 -- us2k117Minor allele frequency- G:0.25NA NS EA WA CSA 926
    rs1161182221,2
    		C,F,--206807198(+) CTGCGG/AATGCA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1465368391,2
    		--206807433(+) CGTAAA/GAGCCC 2 -- us2k10--------
    rs1390977751,2
    		--206807485(+) AGTGGA/GGGAAG 2 -- us2k10--------
    rs1414152991,2
    		--206807674(+) GGGACA/GTTTTT 2 -- us2k10--------
    rs727550551,2
    		C,--206807794(+) TAAGCA/GTTCTA 2 -- us2k10--------
    rs1508164671,2
    		--206807840(+) GAACGC/TTTGGT 2 -- us2k10--------
    rs38139651,2
    		C,F,H,--206807914(-) AAGAAC/TCAGTC 2 -- us2k131Minor allele frequency- T:0.18EA NS NA CSA WA 3888
    rs1908260891,2
    		--206808346(+) AAAGTA/CGTCGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYRK3 (206808881 - 206857764 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DYRK3: --

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    Disorders / Diseases
    for DYRK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DYRK3 for disorders           About GeneDecksing

    OMIM gene information: 603497    OMIM disorders: --

    3 diseases for DYRK3:    About MalaCards
    down syndrome    anemia    malaria


    Export disorders for DYRK3 gene to outside databases

    Publications
    for DYRK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYRK3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with DYRK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PubMed id 9748265)1, 2, 3 Becker W....Joost H.-G. (1998)
    2. REDK, a novel human regulatory erythroid kinase. (PubMed id 10779429)1, 2, 9 Lord K.A....Dillon S.B. (2000)
    3. Molecular cloning and characterization of novel protein kinase gene DYRK3. (PubMed id 9845759)1, 2 Xia J.... Deng H. (1998)
    4. DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. (PubMed id 12356771)1, 9 Li K....Wojchowski D.M. (2002)
    5. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. (PubMed id 15607427)1, 9 Zhang D....Wojchowski D.M. (2005)
    6. DYRK1A and DYRK3 promote cell survival through phosph orylation and activation of SIRT1. (PubMed id 20167603)1, 9 Guo X....Li X. (2010)
    7. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic p athway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DY RK3). (PubMed id 21693704)1 Huang S.H....Jong A. (2011)
    8. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    9. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    10. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. (PubMed id 18854306)1 Bogacheva O....Wojchowski D.M. (2008)

    External Searches for DYRK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DYRK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8444 HGNC: 3094 AceView: DYRK3 Ensembl:ENSG00000143479 euGenes: HUgn8444
    ECgene: DYRK3 H-InvDB: DYRK3

    Other Databases showing DYRK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DYRK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYRK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DYRK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DYRK3 gene:
    Search GeneIP for patents involving DYRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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