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Aliases for DYRK3 Gene

Aliases for DYRK3 Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3 2 3 5
  • Regulatory Erythroid Kinase 2 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 5 2 3
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 3 2 3
  • Protein Kinase Dyrk3 2 3
  • EC 2.7.12.1 4 61
  • REDK 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 3 2
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 3 3
  • EC 2.7.12 61
  • HYAK3-2 3
  • DYRK5 3
  • RED 3

External Ids for DYRK3 Gene

Previous GeneCards Identifiers for DYRK3 Gene

  • GC01P205468
  • GC01P202519
  • GC01P203452
  • GC01P203892
  • GC01P203197
  • GC01P204875
  • GC01P206800
  • GC01P177507

Summaries for DYRK3 Gene

Entrez Gene Summary for DYRK3 Gene

  • This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYRK3 Gene

DYRK3 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK2.

UniProtKB/Swiss-Prot for DYRK3 Gene

  • Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.

Gene Wiki entry for DYRK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK3 Gene

Genomics for DYRK3 Gene

Regulatory Elements for DYRK3 Gene

Enhancers for DYRK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F206657 1.3 FANTOM5 Ensembl ENCODE 18.4 +23.3 23286 3.4 HDGF CBX3 TBL1XR1 RAD21 RARA YY1 GLIS2 GATA2 ZNF143 ETV6 DYRK3 IKBKE MAPKAPK2 EIF2D C1orf147 RASSF5 PIR60472 LOC105372875
GH01F206633 0.5 ENCODE 13.6 -0.1 -81 4.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 DYRK3 MAPKAPK2 EIF2D IKBKE IL19
GH01F206654 0.2 Ensembl 11.7 +19.5 19467 0.4 SCRT2 PBX2 NFE2 MAPKAPK2 DYRK3 EIF2D C1orf147 IKBKE RASSF5 PIR60472 LOC105372875
GH01F206663 0.8 Ensembl ENCODE 11.2 +28.5 28467 1.6 CTCF CBX3 TBL1XR1 DDX20 TAL1 WRNIP1 ETV1 ZNF2 RAD21 ZNF101 DYRK3 EIF2D RASSF5 PIR60472 LOC105372875
GH01F206690 0.5 ENCODE 9.3 +57.5 57487 5.1 PKNOX1 TBL1XR1 ARID4B SIN3A FEZF1 RAD21 ZNF143 CREM MIXL1 ZHX1 IKBKE FCMR PIGR IL10 IL19 EIF2D DYRK3 MAPKAPK2 GC01M206696
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DYRK3 on UCSC Golden Path with GeneCards custom track

Promoters for DYRK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001753919 566 2201 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 SLC30A9 ZNF143
ENSR00000082415 1966 201 ZNF766 ZMYM3 ZSCAN29

Genomic Location for DYRK3 Gene

Chromosome:
1
Start:
206,635,534 bp from pter
End:
206,684,419 bp from pter
Size:
48,886 bases
Orientation:
Plus strand

Genomic View for DYRK3 Gene

Genes around DYRK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK3 Gene

Proteins for DYRK3 Gene

  • Protein details for DYRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43781-DYRK3_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 3
    Protein Accession:
    O43781
    Secondary Accessions:
    • D3DT79
    • Q7Z752
    • Q9HBY6
    • Q9HBY7

    Protein attributes for DYRK3 Gene

    Size:
    588 amino acids
    Molecular mass:
    65714 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DYRK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK3 Gene

Selected DME Specific Peptides for DYRK3 Gene

O43781:
  • LYELIKKN
  • GAYIHVP
  • PGEDEGDQLACM
  • VRNEKRFHRQA
  • IGKGSFGQV
  • GGPNNGGYDD
  • KVIDFGSSC
  • MKVEQLFQEFG

Post-translational modifications for DYRK3 Gene

Other Protein References for DYRK3 Gene

Antibody Products

  • Abcam antibodies for DYRK3
  • Santa Cruz Biotechnology (SCBT) Antibodies for DYRK3

Domains & Families for DYRK3 Gene

Protein Domains for DYRK3 Gene

Suggested Antigen Peptide Sequences for DYRK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43781

UniProtKB/Swiss-Prot:

DYRK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK3: view

Function for DYRK3 Gene

Molecular function for DYRK3 Gene

GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3,expressed in fetal brain,phosphorylating histone H2B
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by harmine, leucettamine B and leucettine L41.
UniProtKB/Swiss-Prot Function:
Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
UniProtKB/Swiss-Prot Induction:
By EPO/erythropoietin.

Enzyme Numbers (IUBMB) for DYRK3 Gene

Gene Ontology (GO) - Molecular Function for DYRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10779429
GO:0004672 protein kinase activity IEA,IDA 10779429
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK3: view
genes like me logo Genes that share phenotypes with DYRK3: view

Animal Models for DYRK3 Gene

MGI Knock Outs for DYRK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK3

miRNA for DYRK3 Gene

miRTarBase miRNAs that target DYRK3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYRK3 Gene

Localization for DYRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYRK3 Gene COMPARTMENTS Subcellular localization image for DYRK3 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DYRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10779429
genes like me logo Genes that share ontologies with DYRK3: view

Pathways & Interactions for DYRK3 Gene

SuperPathways for DYRK3 Gene

No Data Available

SIGNOR curated interactions for DYRK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DYRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 10779429
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0030218 erythrocyte differentiation IDA 10779429
genes like me logo Genes that share ontologies with DYRK3: view

No data available for Pathways by source for DYRK3 Gene

Drugs & Compounds for DYRK3 Gene

(3) Drugs for DYRK3 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ID-8 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for DYRK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for DYRK3 Gene

Compound Action Cas Number
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK3: view

Transcripts for DYRK3 Gene

Unigene Clusters for DYRK3 Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - - - - - - -
SP6: - - - -

Relevant External Links for DYRK3 Gene

GeneLoc Exon Structure for
DYRK3
ECgene alternative splicing isoforms for
DYRK3

Expression for DYRK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYRK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYRK3 Gene

This gene is overexpressed in Testis (x8.5).

Protein differential expression in normal tissues from HIPED for DYRK3 Gene

This gene is overexpressed in Plasma (61.3) and Bone marrow mesenchymal stem cell (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYRK3 Gene



Protein tissue co-expression partners for DYRK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYRK3 Gene:

DYRK3

SOURCE GeneReport for Unigene cluster for DYRK3 Gene:

Hs.164267

mRNA Expression by UniProt/SwissProt for DYRK3 Gene:

O43781-DYRK3_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus.
genes like me logo Genes that share expression patterns with DYRK3: view

Primer Products

Orthologs for DYRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYRK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK3 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia DYRK3 34 35
  • 91.82 (n)
cow
(Bos Taurus)
Mammalia DYRK3 34 35
  • 89.95 (n)
oppossum
(Monodelphis domestica)
Mammalia DYRK3 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk3 34
  • 85.67 (n)
mouse
(Mus musculus)
Mammalia Dyrk3 34 16 35
  • 85.32 (n)
chicken
(Gallus gallus)
Aves DYRK3 34 35
  • 71.88 (n)
lizard
(Anolis carolinensis)
Reptilia DYRK3 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk3 34
  • 67.02 (n)
zebrafish
(Danio rerio)
Actinopterygii DYRK3 35
  • 64 (a)
OneToOne
zgc:172180 34
  • 63.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dyrk3 36 35
  • 66 (a)
smi35A 36
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-2 36 35
  • 67 (a)
C36B7.1 36
  • 32 (a)
C36B7.2 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
OneToMany
Species where no ortholog for DYRK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK3 Gene

ENSEMBL:
Gene Tree for DYRK3 (if available)
TreeFam:
Gene Tree for DYRK3 (if available)

Paralogs for DYRK3 Gene

(4) SIMAP similar genes for DYRK3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DYRK3: view

Variants for DYRK3 Gene

Sequence variations from dbSNP and Humsavar for DYRK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10399719 -- 206,639,048(+) GCTAA(G/T)TTTTG intron-variant
rs10551035 -- 206,650,629(+) TTATT(-/ATT)CTAGA cds-indel
rs10633836 -- 206,641,445(+) ATATA(-/TA)CCATA intron-variant
rs10863755 -- 206,638,239(+) ATGCA(C/T)TTAAT intron-variant
rs10863756 -- 206,638,280(+) ttttt(G/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYRK3 Gene

Variant ID Type Subtype PubMed ID
esv2675844 CNV deletion 23128226
esv3545578 CNV deletion 23714750
esv3588657 CNV loss 21293372

Variation tolerance for DYRK3 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYRK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK3 Gene

Disorders for DYRK3 Gene

Relevant External Links for DYRK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYRK3

No disorders were found for DYRK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK3 Gene

Publications for DYRK3 Gene

  1. REDK, a novel human regulatory erythroid kinase. (PMID: 10779429) Lord K.A. … Dillon S.B. (Blood 2000) 3 4 22 64
  2. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4 64
  3. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. (PMID: 20167603) Guo X. … Li X. (J. Biol. Chem. 2010) 3 22 64
  4. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. (PMID: 15607427) Zhang D. … Wojchowski D.M. (Genomics 2005) 3 22 64
  5. DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. (PMID: 12356771) Li K. … Wojchowski D.M. (J. Biol. Chem. 2002) 3 22 64

Products for DYRK3 Gene

Sources for DYRK3 Gene

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