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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYRK3 Gene

protein-coding   GIFtS: 59
GCID: GC01P206800

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 31 2     DYRK52
Regulatory Erythroid Kinase1 2 3     RED2
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 51 2     Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 32
Protein Kinase Dyrk31 2     hYAK3-22
REDK2 3     EC 2.7.128
EC 2.7.12.13 8     

External Ids:    HGNC: 30941   Entrez Gene: 84442   Ensembl: ENSG000001434797   OMIM: 6034975   UniProtKB: O437813   

Export aliases for DYRK3 gene to outside databases

Previous GC identifers: GC01P205468 GC01P202519 GC01P203452 GC01P203892 GC01P203197 GC01P204875 GC01P177507


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DYRK3 Gene:
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation
on serine/threonine and tyrosine residues. The members of this family share structural similarity, however,
differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded
protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and
H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DYRK3 Gene: 
DYRK3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3) is a protein-coding gene. Diseases associated with DYRK3 include down syndrome, and anemia. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
Function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production
during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells.
May act by regulating CREB/CRE signaling

Gene Wiki entry for DYRK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYRK3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYRK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYRK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

DYRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206800:  view genomic region     (about GC identifiers)

Start:
206,808,881 bp from pter      End:
206,857,764 bp from pter
Size:
48,884 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 3  
Size: 588 amino acids; 65714 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Nucleus
Secondary accessions: D3DT79 Q7Z752 Q9HBY6 Q9HBY7
Alternative splicing: 2 isoforms:  O43781-1   O43781-2   

Explore the universe of human proteins at neXtProt for DYRK3: NX_O43781

Explore proteomics data for DYRK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on tyrosine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43781

  • 4/8 DME Specific Peptides for DYRK3 (O43781) (see all 8)
     GAYIHVP  LYELIKKN  KVIDFGSSC  IGKGSFGQV 

    DYRK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DYRK3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001004023.1  NP_003573.2  

    ENSEMBL proteins: 
     ENSP00000356076   ENSP00000356075   ENSP00000410187   ENSP00000356073  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10779429

    DYRK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 
    Dyrk2 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O43781

    ProtoNet protein and cluster: O43781

    UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    DYRK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYRK3_HUMAN, O43781
    Function: Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production
    during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells.
    May act by regulating CREB/CRE signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: By EPO/erythropoietin

         Genatlas biochemistry entry for DYRK3:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3,expressed in fetal brain,phosphorylating histone
    H2B

         Enzyme Numbers (IUBMB): EC 2.7.12.11 2 EC 2.7.122

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10779429
    GO:0004672protein kinase activity IDA10779429
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
         
    DYRK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DYRK3:
     Decreased substrate adherent c  Increased HPV18 LCR reporter a  Increased apoptosis 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Dyrk3):
     hematopoietic system 

    DYRK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dyrk3tm1Dowo for DYRK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DYRK3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for DYRK3 (O437813 ENSP000003560764) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=1 
    LCE2DENSP000003577734STRING: ENSP00000357773
    LCE4AENSP000003352234STRING: ENSP00000335223
    TMCO2ENSP000003618524STRING: ENSP00000361852
    SIRT1ENSP000002120154STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10779429
    GO:0030218erythrocyte differentiation IDA10779429

    DYRK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYRK3

    3 HMDB Compounds for DYRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about DYRK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DYRK3 gene (2 alternative transcripts): 
    NM_001004023.1  NM_003582.2  

    Unigene Cluster for DYRK3:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
    Hs.164267  [show with all ESTs]
    Unigene Representative Sequence: AF186774
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367109(uc001hej.3) ENST00000367108(uc001hei.3) ENST00000489878(uc001hek.3)
    ENST00000441486 ENST00000367106
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DYRK3:
    hsa-miR-129-3p hsa-miR-129*
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF186773.1 AF186774.1 AF327561.1 AK291189.1 AK308082.1 AK313245.1 AY590695.1 BC015501.1 
    BC037269.1 Y12735.2 

    8 DOTS entries:

    DT.99929445  DT.112352  DT.91806904  DT.75187729  DT.100781944  DT.97840209  DT.91717936  DT.100854078 

    24/76 AceView cDNA sequences (see all 76):

    CA308517 AI433874 CB127400 AF327561 BX101785 BX426158 NM_001004023 AU149589 
    Y12735 AA904950 CA422249 CR609403 BX103376 AF186773 AI095264 BP369169 
    AU126055 CD244393 BC015501 BX366356 AA609672 CD675887 BI827870 BC037269 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DYRK3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                          -     -                 -                                       
    SP2:                          -     -     -                                                   
    SP3:                                -                 -                                       
    SP4:                                                  -                                       
    SP5:        -     -     -     -     -     -           -                                       


    ECgene alternative splicing isoforms for DYRK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYRK3 expression in normal human tissues (normalized intensities)      DYRK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAGCTTC
    DYRK3 Expression
    About this image


    DYRK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Testis (Reproductive System)

    See DYRK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYRK3

    SOURCE GeneReport for Unigene cluster: Hs.164267

    UniProtKB/Swiss-Prot: DYRK3_HUMAN, O43781
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in testis and in hematopoietic tissue such as
    fetal liver, and bone marrow. Isoform 2 is the predominant form in testis. Isoform 1 is the predominant form in
    fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node,
    and thymus

        SABiosciences Custom PCR Arrays for DYRK3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DYRK3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dyrk31 , 5 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 85.32(n)1
    89.93(a)1
      1 (56.90 cM)5
    2264191  NM_145508.21  NP_663483.11 
     1311284415 
    chicken
    (Gallus gallus)
    Aves DYRK31 dual-specificity tyrosine-(Y)-phosphorylation regulated more 71.88(n)
    73.45(a)
      419846  XM_417975.3  XP_417975.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYRK36
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343228.1(1652871-1654421)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1721801 zgc:172180 64.1(n)
    65.15(a)
      100141364  NM_001114928.1  NP_001108400.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dyrk33 protein serine/threonine kinase 66(a)
    (best of 2)
      102F   --
    worm
    (Caenorhabditis elegans)
    Secernentea mbk-23 serine/threonine kinase (2 domains) 67(a)
    (best of 3)
      IV(13031505-13034122)   --


    ENSEMBL Gene Tree for DYRK3 (if available)
    TreeFam Gene Tree for DYRK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYRK3 gene
    DYRK1A2  DYRK22  HIPK12  DYRK42  HIPK32  HIPK42  HIPK22  DYRK1B2  
    4 SIMAP similar genes for DYRK3 using alignment to 3 protein entries:     DYRK3_HUMAN (see all proteins):
    DYRK2    DYRK4    DYRK1B    DYRK1A

    DYRK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 SNPs in DYRK3 are shown (see all 411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0404644
    ----see VAR_0404642 M L mis40--------
    rs1809742811,2
    --206807108(+) AAAGGC/TGGCCT 2 -- us2k10--------
    rs75539441,2
    C,F,A,H--206807154(+) GGAACC/GCTTCC 2 -- us2k117Minor allele frequency- G:0.25NA NS EA WA CSA 926
    rs1161182221,2
    C,F--206807198(+) CTGCGG/AATGCA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1465368391,2
    C--206807433(+) CGTAAA/GAGCCC 2 -- us2k10--------
    rs1390977751,2
    C--206807485(+) AGTGGA/GGGAAG 2 -- us2k10--------
    rs1414152991,2
    --206807674(+) GGGACA/GTTTTT 2 -- us2k10--------
    rs727550551,2
    C--206807794(+) TAAGCA/GTTCTA 2 -- us2k10--------
    rs1508164671,2
    --206807840(+) GAACGC/TTTGGT 2 -- us2k10--------
    rs38139651,2
    C,F,H--206807914(-) AAGAAC/TCAGTC 2 -- us2k131Minor allele frequency- T:0.18EA NS NA CSA WA 3888

    HapMap Linkage Disequilibrium report for DYRK3 (206808881 - 206857764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYRK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675844CNV Deletion23128226
    nsv873128CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603497    OMIM disorders: --

    3 diseases for DYRK3:    About MalaCards
    down syndrome    anemia    endotheliitis


    DYRK3 for disorders           About GeneDecksing


    Export disorders for DYRK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYRK3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DYRK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PubMed id 9748265)1, 2, 3 Becker W....Joost H.-G. (1998)
    2. REDK, a novel human regulatory erythroid kinase. (PubMed id 10779429)1, 2, 9 Lord K.A....Dillon S.B. (2000)
    3. Molecular cloning and characterization of novel protein kinase gene DYRK3. (PubMed id 9845759)1, 2 Xia J.... Deng H. (1998)
    4. DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival. (PubMed id 12356771)1, 9 Li K....Wojchowski D.M. (2002)
    5. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. (PubMed id 15607427)1, 9 Zhang D....Wojchowski D.M. (2005)
    6. DYRK1A and DYRK3 promote cell survival through phosph orylation and activation of SIRT1. (PubMed id 20167603)1, 9 Guo X....Li X. (2010)
    7. Dual specificity kinase DYRK3 couples stress granule c ondensation/dissolution to mTORC1 signaling. (PubMed id 23415227)1 Wippich F....Pelkmans L. (2013)
    8. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic p athway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DY RK3). (PubMed id 21693704)1 Huang S.H....Jong A. (2011)
    9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    10. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8444 HGNC: 3094 AceView: DYRK3 Ensembl:ENSG00000143479 euGenes: HUgn8444
    ECgene: DYRK3 H-InvDB: DYRK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYRK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DYRK3 gene:
    Search GeneIP for patents involving DYRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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