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Aliases for DYRK2 Gene

Aliases for DYRK2 Gene

  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 2 3
  • EC 2.7.12.1 4 63
  • EC 2.7.12 63

External Ids for DYRK2 Gene

Previous GeneCards Identifiers for DYRK2 Gene

  • GC12P067846
  • GC12P067759
  • GC12P066329
  • GC12P066328
  • GC12P068042
  • GC12P065093

Summaries for DYRK2 Gene

Entrez Gene Summary for DYRK2 Gene

  • DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYRK2 Gene

DYRK2 (Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and p53 pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is DYRK1B.

UniProtKB/Swiss-Prot for DYRK2 Gene

  • Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).

Gene Wiki entry for DYRK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK2 Gene

Genomics for DYRK2 Gene

Regulatory Elements for DYRK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DYRK2 Gene

Start:
67,648,338 bp from pter
End:
67,665,406 bp from pter
Size:
17,069 bases
Orientation:
Plus strand

Genomic View for DYRK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK2 Gene

Proteins for DYRK2 Gene

  • Protein details for DYRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92630-DYRK2_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 2
    Protein Accession:
    Q92630
    Secondary Accessions:
    • B2R9V9
    • Q9BRB5

    Protein attributes for DYRK2 Gene

    Size:
    601 amino acids
    Molecular mass:
    66652 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and VPRBP. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
    SequenceCaution:
    • Sequence=CAA73885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DYRK2 Gene

    Alternative splice isoforms for DYRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK2 Gene

Proteomics data for DYRK2 Gene at MOPED

Post-translational modifications for DYRK2 Gene

  • Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
  • Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYRK2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)

Domains for DYRK2 Gene

Suggested Antigen Peptide Sequences for DYRK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92630

UniProtKB/Swiss-Prot:

DYRK2_HUMAN :
  • Q92630
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK2: view

Function for DYRK2 Gene

Molecular function for DYRK2 Gene

GENATLAS Biochemistry: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2,phosphorylating histone H2B
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Inhibited by acridine analogs, purvalanol, and barely by harmine. Inhibited by leucettine and leucettine derivatives.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
UniProtKB/Swiss-Prot Induction: Accumulates in nucleus upon DNA damage. Induced in both esophageal and lung adenocarcinomas.

Enzyme Numbers (IUBMB) for DYRK2 Gene

Gene Ontology (GO) - Molecular Function for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9748265
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 11311121
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IDA 9748265
genes like me logo Genes that share ontologies with DYRK2: view
genes like me logo Genes that share phenotypes with DYRK2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYRK2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DYRK2 Gene

Localization for DYRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK2 Gene

Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYRK2 Gene COMPARTMENTS Subcellular localization image for DYRK2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 19287380
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with DYRK2: view

Pathways for DYRK2 Gene

genes like me logo Genes that share pathways with DYRK2: view

Pathways by source for DYRK2 Gene

1 Cell Signaling Technology pathway for DYRK2 Gene
1 BioSystems pathway for DYRK2 Gene
1 GeneGo (Thomson Reuters) pathway for DYRK2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11311121
GO:0006974 cellular response to DNA damage stimulus IEP 19965871
GO:0007224 smoothened signaling pathway IMP 18455992
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA 17349958
genes like me logo Genes that share ontologies with DYRK2: view

Compounds for DYRK2 Gene

(4) HMDB Compounds for DYRK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with DYRK2: view

Transcripts for DYRK2 Gene

Unigene Clusters for DYRK2 Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYRK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for DYRK2 Gene

GeneLoc Exon Structure for
DYRK2
ECgene alternative splicing isoforms for
DYRK2

Expression for DYRK2 Gene

mRNA expression in normal human tissues for DYRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DYRK2 Gene

SOURCE GeneReport for Unigene cluster for DYRK2 Gene Hs.173135

mRNA Expression by UniProt/SwissProt for DYRK2 Gene

Q92630-DYRK2_HUMAN
Tissue specificity: Testis, after the onset of spermatogenesis.
genes like me logo Genes that share expressions with DYRK2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DYRK2 Gene

Orthologs for DYRK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK2 35
  • 99.67 (n)
  • 100 (a)
DYRK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK2 35
  • 92.54 (n)
  • 98.5 (a)
DYRK2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYRK2 35
  • 93.34 (n)
  • 98.67 (a)
DYRK2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dyrk2 35
  • 90.76 (n)
  • 97.5 (a)
Dyrk2 16
Dyrk2 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk2 35
  • 90.51 (n)
  • 98.29 (a)
chicken
(Gallus gallus)
Aves DYRK2 35
  • 82.13 (n)
  • 92.97 (a)
DYRK2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYRK2 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4918 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk2 35
  • 77.24 (n)
  • 89.37 (a)
zebrafish
(Danio rerio)
Actinopterygii dyrk2 35
  • 74.73 (n)
  • 85.01 (a)
dyrk2 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008241 35
  • 64.93 (n)
  • 65.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dyrk3 35
  • 64.15 (n)
  • 72.54 (a)
Dyrk3 36
  • 39 (a)
OneToMany
smi35A 37
  • 53 (a)
Dyrk3 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-2 35
  • 66.07 (n)
  • 73.45 (a)
mbk-2 36
  • 38 (a)
OneToMany
C36B7.2 37
  • 31 (a)
C36B7.1 37
  • 30 (a)
mbk-2 37
  • 73 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06638 35
  • 51.39 (n)
  • 46.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
OneToMany
Species with no ortholog for DYRK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK2 Gene

ENSEMBL:
Gene Tree for DYRK2 (if available)
TreeFam:
Gene Tree for DYRK2 (if available)

Paralogs for DYRK2 Gene

Selected SIMAP similar genes for DYRK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DYRK2: view

Variants for DYRK2 Gene

Sequence variations from dbSNP and Humsavar for DYRK2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11869 -- 67,661,073(+) AAACT(A/T)TAATA utr-variant-3-prime
rs11938 -- 67,662,312(-) AATTA(C/G)AATTA utr-variant-3-prime
rs1136138 -- 67,660,906(+) GAGCC(C/T)GCCAT utr-variant-3-prime
rs1731542 -- 67,655,350(+) TGTCT(A/G)GTGTT intron-variant
rs1731546 -- 67,646,826(+) TTTTG(C/T)TTCAT upstream-variant-2KB

Relevant External Links for DYRK2 Gene

HapMap Linkage Disequilibrium report
DYRK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DYRK2 Gene

Disorders for DYRK2 Gene

(1) Novoseek inferred disease relationships for DYRK2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for DYRK2

Genetic Association Database (GAD)
DYRK2
Human Genome Epidemiology (HuGE) Navigator
DYRK2
genes like me logo Genes that share disorders with DYRK2: view

No data available for UniProtKB/Swiss-Prot for DYRK2 Gene

Publications for DYRK2 Gene

  1. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (PMID: 17349958) Taira N. … Yoshida K. (Mol. Cell 2007) 3 4 23
  2. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4
  3. The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3- priming kinase. (PMID: 11311121) Woods Y.L. … Proud C.G. (Biochem. J. 2001) 3 4
  4. Amplification and overexpression of the dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas. (PMID: 12874018) Miller C.T. … Lin L. (Cancer Res. 2003) 4 23
  5. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. (PMID: 12588975) Wang X. … Proud C.G. (Mol. Cell. Biol. 2003) 3 4

Products for DYRK2 Gene

  • Addgene plasmids for DYRK2

Sources for DYRK2 Gene

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