Aliases for DYRK2 Gene
Aliases for DYRK2 Gene
External Ids for DYRK2 Gene
- HGNC: 3093
- Entrez Gene: 8445
- Ensembl: ENSG00000127334
- OMIM: 603496
- UniProtKB: Q92630
Previous GeneCards Identifiers for DYRK2 Gene
- GC12P067846
- GC12P067759
- GC12P066329
- GC12P066328
- GC12P068042
- GC12P065093
Summaries for DYRK2 Gene
-
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
GeneCards Summary for DYRK2 Gene
DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Among its related pathways are T-Cell Receptor and Co-stimulatory Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK3.
UniProtKB/Swiss-Prot for DYRK2 Gene
-
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
Additional gene information for DYRK2 Gene
- Monarch Initiative
- Search for DYRK2 at DataMed
- Search for DYRK2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK2 Gene
Genomics for DYRK2 Gene
GeneHancer (GH) Regulatory Elements for DYRK2 Gene
Promoters and enhancers for DYRK2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12I067646 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +1.2 | 1216 | 5.1 | PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 ZNF121 POLR2B GLIS2 ZNF207 | DYRK2 LINC01479 GC12P067661 | |
| GH12I067678 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 12.4 | +30.4 | 30370 | 1.2 | JUND POLR2A FOSL2 FOS | LOC105369816 DYRK2 LINC01479 LINC02421 | |
| GH12I067680 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 12.4 | +33.0 | 32985 | 1.4 | JUND FOSL2 FOS | DYRK2 LINC01479 LOC105369816 LINC02421 | |
| GH12I068556 | Enhancer | 0.9 | Ensembl ENCODE | 10.7 | +909.4 | 909410 | 2 | SMARCE1 MCM3 PHF21A JUN ZSCAN4 ZNF398 ZEB2 ZNF2 ZFHX2 JUND | NUP107 RPL10P12 RAP1B KRT8P39 LINC02384 SNORA70G MDM1 DYRK2 CPSF6 RPSAP12 | |
| GH12I067628 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 4.6 | -18.3 | -18341 | 3 | MAX EBF1 POLR2A SCRT2 VEZF1 ETV6 IKZF2 RUNX3 SCRT1 NR2F1 | ENSG00000235872 DYRK2 LINC02442 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DYRK2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DYRK2 Gene
Genomic Locations for DYRK2 Gene
- chr12:67,648,338-67,665,406
- (GRCh38/hg38)
- Size:
- 17,069 bases
- Orientation:
- Plus strand
- chr12:68,042,118-68,059,186
- (GRCh37/hg19)
Genomic View for DYRK2 Gene
Genes around DYRK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q15 by Ensembl
- 12q15 by Entrez Gene
- 12q15 by HGNC
DYRK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DYRK2 Gene
Proteins for DYRK2 Gene
-
Protein details for DYRK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92630-DYRK2_HUMAN
- Recommended name:
- Dual specificity tyrosine-phosphorylation-regulated kinase 2
- Protein Accession:
- Q92630
- B2R9V9
- Q9BRB5
Protein attributes for DYRK2 Gene
- Size:
- 601 amino acids
- Molecular mass:
- 66652 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and DCAF1. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
- SequenceCaution:
-
- Sequence=CAA73885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for DYRK2 Gene
Protein Expression for DYRK2 Gene
Selected DME Specific Peptides for DYRK2 Gene
- Q92630:
-
- PGEDEGDQLACM
- VRNEKRFHRQA
- GGPNNGGYDD
- KVIDFGSSC
- LYELIKKN
- IGKGSFGQV
- HPWLRRRLP
- NAKKRQG
- TFELLSMNLY
Post-translational modifications for DYRK2 Gene
- Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
- Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
Other Protein References for DYRK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DYRK2 (DYRK2)
- Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)
-
Custom Antibody ServicesOriGene Antibodies for DYRK2
- Novus Biologicals Antibodies for DYRK2
-
Abcam antibodies for DYRK2
- Invitrogen Antibodies for DYRK2
- GeneTex DYRK2 antibody for DYRK2
-
Custom Antibody ServicesProSci Antibodies for DYRK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2
Protein Products
-
OriGene Purified Proteins for DYRK2
- Search Origene for MassSpec and Protein Over-expression Lysates for DYRK2
- Origene Custom Protein Services for DYRK2
- Novus Biologicals proteins for DYRK2
- Search GeneTex for Proteins for DYRK2
-
Abcam proteins for DYRK2
Assay Products
Domains & Families for DYRK2 Gene
Gene Families for DYRK2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for DYRK2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DYRK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92630UniProtKB/Swiss-Prot:
DYRK2_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Function for DYRK2 Gene
Molecular function for DYRK2 Gene
- GENATLAS Biochemistry:
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2,phosphorylating histone H2B
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Inhibited by acridine analogs, purvalanol, and barely by harmine. Inhibited by leucettine and leucettine derivatives.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
- UniProtKB/Swiss-Prot Induction:
- Accumulates in nucleus upon DNA damage. Induced in both esophageal and lung adenocarcinomas.
Enzyme Numbers (IUBMB) for DYRK2 Gene
Phenotypes From GWAS Catalog for DYRK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 9748265 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | -- |
Phenotypes for DYRK2 Gene
- GenomeRNAi human phenotypes for DYRK2:
-
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased IL-8 secretion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Increased cell viability after pRB stimulation
- Increased mitotic index
- Increased cell migration
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Upregulation of NF-kappaB pathway after LMP1 stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DYRK2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- Search ViGene Biosciences for DYRK2
CRISPR Products
-
OriGene CRISPR knockouts for DYRK2
- genomics-online: gRNA clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
- Applied Biological Materials CRISPR for DYRK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
miRNA for DYRK2 Gene
- miRTarBase miRNAs that target DYRK2
-
- hsa-mir-103a-3p (MIRT027110)
- hsa-mir-98-5p (MIRT027686)
- hsa-mir-93-5p (MIRT028150)
- hsa-mir-484 (MIRT041925)
- hsa-mir-378a-3p (MIRT043899)
- hsa-mir-197-3p (MIRT048134)
- hsa-mir-196a-5p (MIRT048265)
- hsa-let-7e-5p (MIRT051470)
- hsa-let-7f-5p (MIRT054391)
- hsa-mir-24-3p (MIRT054393)
- hsa-mir-1252-3p (MIRT066578)
- hsa-mir-6869-5p (MIRT066582)
- hsa-mir-590-3p (MIRT066654)
- hsa-mir-297 (MIRT066657)
- hsa-mir-3160-3p (MIRT066658)
- hsa-mir-3924 (MIRT066659)
- hsa-mir-4775 (MIRT066661)
- hsa-mir-8077 (MIRT066663)
- hsa-mir-107 (MIRT066664)
- hsa-mir-187-3p (MIRT066665)
- hsa-mir-382-5p (MIRT066666)
- hsa-mir-495-5p (MIRT066667)
- hsa-mir-744-3p (MIRT066668)
- hsa-mir-4704-3p (MIRT066669)
- hsa-mir-6504-3p (MIRT066670)
- hsa-mir-6767-3p (MIRT066671)
- hsa-mir-193a-3p (MIRT066673)
- hsa-mir-193b-3p (MIRT066674)
- hsa-mir-17-5p (MIRT188182)
- hsa-mir-20a-5p (MIRT188183)
- hsa-mir-106a-5p (MIRT188184)
- hsa-mir-106b-5p (MIRT188187)
- hsa-mir-20b-5p (MIRT188188)
- hsa-mir-526b-3p (MIRT188189)
- hsa-mir-519d-3p (MIRT188190)
- hsa-mir-3609 (MIRT188193)
- hsa-mir-548ah-5p (MIRT188194)
- hsa-mir-4796-3p (MIRT188195)
- hsa-mir-30c-2-3p (MIRT241913)
- hsa-mir-30b-3p (MIRT241914)
- hsa-mir-30c-1-3p (MIRT241916)
- hsa-mir-496 (MIRT241917)
- hsa-mir-887-5p (MIRT241918)
- hsa-mir-3662 (MIRT241919)
- hsa-mir-3689a-3p (MIRT241920)
- hsa-mir-3689b-3p (MIRT241921)
- hsa-mir-3689c (MIRT241922)
- hsa-mir-5701 (MIRT241924)
- hsa-mir-6779-5p (MIRT241925)
- hsa-mir-6780a-5p (MIRT241926)
- hsa-mir-6788-5p (MIRT241927)
- hsa-mir-1273h-5p (MIRT241928)
- hsa-mir-3941 (MIRT248671)
- hsa-mir-8485 (MIRT248673)
- hsa-mir-5010-3p (MIRT477854)
- hsa-mir-2113 (MIRT477855)
- hsa-mir-210-3p (MIRT477856)
- hsa-mir-4665-5p (MIRT477857)
- hsa-mir-147b (MIRT477858)
- hsa-mir-1275 (MIRT477859)
- hsa-mir-4472 (MIRT477860)
- hsa-mir-4447 (MIRT477861)
- hsa-mir-92a-2-5p (MIRT477862)
- hsa-mir-5010-5p (MIRT477863)
- hsa-mir-4525 (MIRT477864)
- hsa-mir-7111-5p (MIRT477865)
- hsa-mir-6870-5p (MIRT477866)
- hsa-mir-4723-5p (MIRT477867)
- hsa-mir-5698 (MIRT477868)
- hsa-mir-625-5p (MIRT477869)
- hsa-mir-6739-5p (MIRT477870)
- hsa-mir-6733-5p (MIRT477871)
- hsa-mir-3153 (MIRT477872)
- hsa-mir-4746-3p (MIRT477873)
- hsa-mir-6786-5p (MIRT477874)
- hsa-mir-4328 (MIRT477875)
- hsa-mir-548b-3p (MIRT477876)
- hsa-mir-629-5p (MIRT537893)
- hsa-mir-4686 (MIRT537894)
- hsa-mir-5047 (MIRT537895)
- hsa-mir-1301-3p (MIRT537896)
- hsa-mir-7156-3p (MIRT537897)
- hsa-mir-603 (MIRT537898)
- hsa-mir-362-3p (MIRT537899)
- hsa-mir-329-3p (MIRT537900)
- hsa-mir-101-3p (MIRT537901)
- hsa-mir-509-3p (MIRT537902)
- hsa-mir-4717-3p (MIRT537903)
- hsa-mir-411-3p (MIRT537904)
- hsa-mir-379-3p (MIRT537905)
- hsa-mir-4461 (MIRT537906)
- hsa-mir-670-5p (MIRT542994)
- hsa-mir-4732-3p (MIRT542995)
- hsa-mir-345-3p (MIRT542996)
- hsa-mir-545-5p (MIRT542997)
- hsa-mir-3613-3p (MIRT542998)
- hsa-mir-125a-5p (MIRT542999)
- hsa-mir-125b-5p (MIRT543000)
- hsa-mir-4319 (MIRT543001)
- hsa-mir-3912-5p (MIRT558249)
- hsa-mir-567 (MIRT558250)
- hsa-mir-4487 (MIRT558251)
- hsa-mir-558 (MIRT558252)
- hsa-mir-6834-3p (MIRT558253)
- hsa-mir-7849-3p (MIRT558254)
- hsa-mir-4786-5p (MIRT704078)
- hsa-mir-1288-5p (MIRT704079)
- hsa-mir-195-3p (MIRT704080)
- hsa-mir-16-2-3p (MIRT704081)
- hsa-mir-383-5p (MIRT704082)
- hsa-mir-4523 (MIRT704083)
- hsa-mir-548ay-3p (MIRT704084)
- hsa-mir-548at-3p (MIRT704085)
- hsa-mir-548as-3p (MIRT704086)
- hsa-mir-548t-3p (MIRT704087)
- hsa-mir-548ap-3p (MIRT704088)
- hsa-mir-548aa (MIRT704089)
- hsa-mir-582-5p (MIRT708147)
miRNA Products
- Search ViGene Biosciences for DYRK2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DYRK2
- Browse OriGene Inhibitory RNA Products For DYRK2
- genomics-online: shRNA clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
Clone Products
- Sino Biological Human cDNA Clone for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DYRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYRK2
- Applied Biological Materials Clones for DYRK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DYRK2
-
ViGene Biosciences adenoviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYRK2 Gene
Localization for DYRK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DYRK2 Gene
- Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 19287380 |
| GO:0005634 | nucleus | IDA,IEA | 17349958 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | TAS,IDA | 17349958 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for DYRK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of TP53 Activity | ||
| 2 | Gene Expression |
.48
|
|
| 3 | DNA Damage | ||
| 4 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 5 | p53 pathway | ||
Pathways by source for DYRK2 Gene
1 Cell Signaling Technology pathway for DYRK2 Gene
2 BioSystems pathways for DYRK2 Gene
5 Reactome pathways for DYRK2 Gene
1 GeneGo (Thomson Reuters) pathway for DYRK2 Gene
Interacting Proteins for DYRK2 Gene
Selected Interacting proteins:
ENSP00000342105
Q92630-DYRK2_HUMAN
for DYRK2 Gene via
STRING
IID
UniProtKB
SIGNOR curated interactions for DYRK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 11311121 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEP | 19965871 |
| GO:0007224 | smoothened signaling pathway | IMP | 18455992 |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for DYRK2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(1) ApexBio Compounds for DYRK2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ID-8 | 147591-46-6 |
Transcripts for DYRK2 Gene
mRNA/cDNA for DYRK2 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DYRK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DYRK2
- genomics-online: gRNA clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
- Applied Biological Materials CRISPR for DYRK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
miRNA Products
- Search ViGene Biosciences for DYRK2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DYRK2
- Browse OriGene Inhibitory RNA Products For DYRK2
- genomics-online: shRNA clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
Clone Products
- Sino Biological Human cDNA Clone for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DYRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYRK2
- Applied Biological Materials Clones for DYRK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | - | - | ||||||||||||
| SP4: | - |
Expression for DYRK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Adipocyte (63.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYRK2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DYRK2 Gene:
DYRK2SOURCE GeneReport for Unigene cluster for DYRK2 Gene:
Hs.173135mRNA Expression by UniProt/SwissProt for DYRK2 Gene:
Q92630-DYRK2_HUMAN
Tissue specificity:
Testis, after the onset of spermatogenesis.
Evidence on tissue expression from TISSUES for DYRK2 Gene
- Nervous system(4.7)
- Muscle(4.4)
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs for DYRK2
-
OriGene qPCR primer pairs and template standards for DYRK2
- genomics-online: primer clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK2 Gene
Orthologs for DYRK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DYRK2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DYRK2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DYRK2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Dyrk2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dyrk2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DYRK2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DYRK2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DYRK2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dyrk2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4918 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dyrk2 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008241 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dyrk3 35 33 34 |
|
||
| smi35A 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | mbk-2 35 33 34 |
|
||
| C36B7.2 35 |
|
|
|||
| C36B7.1 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06638 33 |
|
- Species where no ortholog for DYRK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DYRK2 Gene
Paralogs for DYRK2 Gene
(7) SIMAP similar genes for DYRK2 Gene using alignment to 5 proteins:
Variants for DYRK2 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040459 | A glioblastoma multiforme sample | p.Pro198Leu | |||
| rs1000225280 | -- | 67,647,477(+) | C/G | upstream_transcript_variant | |
| rs1000252230 | -- | 67,653,159(+) | C/G | intron_variant | |
| rs1000316208 | -- | 67,649,566(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000946321 | -- | 67,664,681(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1143702 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.54;
29.92% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DYRK2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DYRK2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK2 Gene
Disorders for DYRK2 Gene
Additional Disease Information for DYRK2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for DYRK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK2 Gene
Publications for DYRK2 Gene
- DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (PMID: 17349958) Taira N … Yoshida K (Molecular cell 2007) 3 4 22 58
- Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W … Joost HG (The Journal of biological chemistry 1998) 2 3 4 58
- Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. (PMID: 23362280) Jung HY … Park JI (The Journal of biological chemistry 2013) 3 4 58
- DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PMID: 22307329) Taira N … Yoshida K (The Journal of clinical investigation 2012) 3 4 58
- Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. (PMID: 22878263) Pérez M … Calzado MA (Journal of molecular cell biology 2012) 3 4 58
Products for DYRK2 Gene
- R&D Systems Antibodies for DYRK2 (DYRK2)
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for DYRK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for DYRK2
- VectorBuilder custom plasmid, inducible vectors for DYRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYRK2
- antibodies-online: Search results for 100 available DYRK2 Antibodies ranked by validation data
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- GeneTex DYRK2 antibody for DYRK2
- Search GeneTex for Proteins for DYRK2
- ViGene Biosciences adenoviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- Search ViGene Biosciences for DYRK2
- Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2
- Search Santa Cruz Biotechnology (SCBT) for DYRK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- Horizon Cell Lines for DYRK2
- genomics-online: cdna clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
- orf clones - Search results for 118 available DYRK2 gene related products
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- genomics-online: gRNA clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
- genomics-online: primer clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
- genomics-online: shRNA clones - Search results for 118 available DYRK2 gene related products
- Overview of 118 available DYRK2 gene related products
Sources for DYRK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew