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Aliases for DYRK2 Gene

Aliases for DYRK2 Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2 2 3 5
  • EC 2.7.12.1 4 61
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 2
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2 2
  • EC 2.7.12 61

External Ids for DYRK2 Gene

Previous GeneCards Identifiers for DYRK2 Gene

  • GC12P067846
  • GC12P067759
  • GC12P066329
  • GC12P066328
  • GC12P068042
  • GC12P065093

Summaries for DYRK2 Gene

Entrez Gene Summary for DYRK2 Gene

  • DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYRK2 Gene

DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK3.

UniProtKB/Swiss-Prot for DYRK2 Gene

  • Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).

Gene Wiki entry for DYRK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK2 Gene

Genomics for DYRK2 Gene

Regulatory Elements for DYRK2 Gene

Enhancers for DYRK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F067680 0.7 Ensembl ENCODE 12.3 +33.0 32985 1.4 JUND FOS DYRK2 LINC01479 LOC105369816 LOC101927901
GH12F067678 1.2 Ensembl ENCODE 12.3 +30.3 30313 1.3 JUND FOS DYRK2 LINC01479 LOC105369816 LOC101927901
GH12F067682 0.2 ENCODE 12.3 +33.8 33788 0.1 DYRK2 LOC105369816 LOC101927901
GH12F067628 1.2 FANTOM5 Ensembl ENCODE 4.5 -17.7 -17722 4.3 SCRT1 MAX CEBPB GABPA NR2F2 SP1 SCRT2 IKZF1 ETV6 NR2F6 ENSG00000235872 DYRK2 LOC105369815
GH12F067988 1.4 FANTOM5 Ensembl ENCODE 2 +342.5 342491 4.8 PKNOX1 ESRRA GTF2E2 EBF1 RELA GATA3 POLR2A CBX5 EED NR2F6 IFNG-AS1 LINC01479 IFNG IL22 DYRK2 RPL39P28
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DYRK2 on UCSC Golden Path with GeneCards custom track

Promoters for DYRK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089269 1562 4201 ARID4B SIN3A DMAP1 ZNF48 GLIS2 KLF7 MXD4 REST TBX21 SMARCA4

Genomic Location for DYRK2 Gene

Chromosome:
12
Start:
67,648,338 bp from pter
End:
67,665,406 bp from pter
Size:
17,069 bases
Orientation:
Plus strand

Genomic View for DYRK2 Gene

Genes around DYRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK2 Gene

Proteins for DYRK2 Gene

  • Protein details for DYRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92630-DYRK2_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 2
    Protein Accession:
    Q92630
    Secondary Accessions:
    • B2R9V9
    • Q9BRB5

    Protein attributes for DYRK2 Gene

    Size:
    601 amino acids
    Molecular mass:
    66652 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and VPRBP. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
    SequenceCaution:
    • Sequence=CAA73885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DYRK2 Gene

    Alternative splice isoforms for DYRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK2 Gene

Selected DME Specific Peptides for DYRK2 Gene

Q92630:
  • PGEDEGDQLACM
  • VRNEKRFHRQA
  • GGPNNGGYDD
  • KVIDFGSSC
  • LYELIKKN
  • IGKGSFGQV
  • HPWLRRRLP
  • NAKKRQG
  • TFELLSMNLY

Post-translational modifications for DYRK2 Gene

  • Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
  • Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYRK2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2

Domains & Families for DYRK2 Gene

Protein Domains for DYRK2 Gene

Suggested Antigen Peptide Sequences for DYRK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92630

UniProtKB/Swiss-Prot:

DYRK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK2: view

Function for DYRK2 Gene

Molecular function for DYRK2 Gene

GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2,phosphorylating histone H2B
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Inhibited by acridine analogs, purvalanol, and barely by harmine. Inhibited by leucettine and leucettine derivatives.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
UniProtKB/Swiss-Prot Induction:
Accumulates in nucleus upon DNA damage. Induced in both esophageal and lung adenocarcinomas.

Enzyme Numbers (IUBMB) for DYRK2 Gene

Gene Ontology (GO) - Molecular Function for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 9748265
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK2: view
genes like me logo Genes that share phenotypes with DYRK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK2

miRNA for DYRK2 Gene

miRTarBase miRNAs that target DYRK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DYRK2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYRK2 Gene

Localization for DYRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK2 Gene

Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYRK2 Gene COMPARTMENTS Subcellular localization image for DYRK2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 19287380
GO:0005634 nucleus IEA,IDA 17349958
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,TAS 17349958
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DYRK2: view

Pathways & Interactions for DYRK2 Gene

genes like me logo Genes that share pathways with DYRK2: view

Pathways by source for DYRK2 Gene

1 Cell Signaling Technology pathway for DYRK2 Gene
1 BioSystems pathway for DYRK2 Gene

SIGNOR curated interactions for DYRK2 Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for DYRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,TAS 11311121
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEP 19965871
GO:0007224 smoothened signaling pathway IMP 18455992
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DYRK2: view

Drugs & Compounds for DYRK2 Gene

(4) Drugs for DYRK2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Manganese Approved Nutra 34
ID-8 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for DYRK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for DYRK2 Gene

Compound Action Cas Number
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK2: view

Transcripts for DYRK2 Gene

Unigene Clusters for DYRK2 Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DYRK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for DYRK2 Gene

GeneLoc Exon Structure for
DYRK2
ECgene alternative splicing isoforms for
DYRK2

Expression for DYRK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DYRK2 Gene

This gene is overexpressed in Adipocyte (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYRK2 Gene



Protein tissue co-expression partners for DYRK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYRK2 Gene:

DYRK2

SOURCE GeneReport for Unigene cluster for DYRK2 Gene:

Hs.173135

mRNA Expression by UniProt/SwissProt for DYRK2 Gene:

Q92630-DYRK2_HUMAN
Tissue specificity: Testis, after the onset of spermatogenesis.
genes like me logo Genes that share expression patterns with DYRK2: view

Primer Products

No data available for mRNA differential expression in normal tissues for DYRK2 Gene

Orthologs for DYRK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK2 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia DYRK2 34 35
  • 93.34 (n)
cow
(Bos Taurus)
Mammalia DYRK2 34 35
  • 92.54 (n)
mouse
(Mus musculus)
Mammalia Dyrk2 34 16 35
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Dyrk2 34
  • 90.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYRK2 34 35
  • 82.13 (n)
lizard
(Anolis carolinensis)
Reptilia DYRK2 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk2 34
  • 77.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4918 34
zebrafish
(Danio rerio)
Actinopterygii dyrk2 34 35
  • 74.73 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008241 34
  • 64.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dyrk3 36 34 35
  • 64.15 (n)
smi35A 36
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-2 36 34 35
  • 66.07 (n)
C36B7.2 36
  • 31 (a)
C36B7.1 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 77 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06638 34
  • 51.39 (n)
Species where no ortholog for DYRK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK2 Gene

ENSEMBL:
Gene Tree for DYRK2 (if available)
TreeFam:
Gene Tree for DYRK2 (if available)

Paralogs for DYRK2 Gene

(7) SIMAP similar genes for DYRK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DYRK2: view

Variants for DYRK2 Gene

Sequence variations from dbSNP and Humsavar for DYRK2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_040459 A glioblastoma multiforme sample
rs10467153 -- 67,662,032(+) ATGAC(C/T)CCATC utr-variant-3-prime
rs10784638 -- 67,664,257(+) CATAT(A/G)TATAT utr-variant-3-prime
rs10878641 -- 67,651,623(+) ACTTC(A/G)GTATG intron-variant
rs111601548 -- 67,664,316(+) ATGAG(A/G)AAACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DYRK2 Gene

Variant ID Type Subtype PubMed ID
nsv1143702 CNV deletion 24896259

Variation tolerance for DYRK2 Gene

Residual Variation Intolerance Score: 8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYRK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK2 Gene

Disorders for DYRK2 Gene

Relevant External Links for DYRK2

Genetic Association Database (GAD)
DYRK2
Human Genome Epidemiology (HuGE) Navigator
DYRK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYRK2

No disorders were found for DYRK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK2 Gene

Publications for DYRK2 Gene

  1. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (PMID: 17349958) Taira N. … Yoshida K. (Mol. Cell 2007) 3 4 22 64
  2. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4 64
  3. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. (PMID: 23362280) Jung H.Y. … Park J.I. (J. Biol. Chem. 2013) 3 4 64
  4. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PMID: 22307329) Taira N. … Yoshida K. (J. Clin. Invest. 2012) 3 4 64
  5. Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. (PMID: 22878263) Perez M. … Calzado M.A. (J. Mol. Cell Biol. 2012) 3 4 64

Products for DYRK2 Gene

Sources for DYRK2 Gene

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