Aliases for DYRK2 Gene
Aliases for DYRK2 Gene
External Ids for DYRK2 Gene
- HGNC: 3093
- Entrez Gene: 8445
- Ensembl: ENSG00000127334
- OMIM: 603496
- UniProtKB: Q92630
Previous GeneCards Identifiers for DYRK2 Gene
- GC12P067846
- GC12P067759
- GC12P066329
- GC12P066328
- GC12P068042
- GC12P065093
Summaries for DYRK2 Gene
-
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
GeneCards Summary for DYRK2 Gene
DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Gene Expression. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK3.
UniProtKB/Swiss-Prot for DYRK2 Gene
-
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK2 Gene
Genomics for DYRK2 Gene
Regulatory Elements for DYRK2 Gene
Enhancers for DYRK2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G067678 | 1 | Ensembl ENCODE dbSUPER | 12.4 | +30.4 | 30371 | 1.2 | JUND FOS ATF2 | DYRK2 LINC01479 LOC105369816 LINC02421 |
| GH12G067680 | 0.9 | Ensembl ENCODE dbSUPER | 12.4 | +33.0 | 32985 | 1.4 | JUND FOS | DYRK2 LINC01479 LOC105369816 LINC02421 |
| GH12G067682 | 0.5 | ENCODE dbSUPER | 12.4 | +33.8 | 33788 | 0.1 | DYRK2 LOC105369816 LINC02421 | |
| GH12G067628 | 1.3 | FANTOM5 Ensembl ENCODE | 4.6 | -18.3 | -18342 | 3.0 | CTCF MAX CEBPG ARID3A SCRT2 NR2F6 ETV6 RELB IKZF2 SCRT1 | ENSG00000235872 DYRK2 LINC02442 |
| GH12G067988 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 2 | +342.5 | 342491 | 4.8 | PKNOX1 ZSCAN4 CBX5 RELB IKZF2 CEBPB TBX21 SP1 SMARCA4 IKZF1 | IFNG-AS1 LINC01479 IFNG IL22 DYRK2 RPL39P28 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around DYRK2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for DYRK2 Gene
- Chromosome:
- 12
- Start:
- 67,648,338 bp from pter
- End:
- 67,665,406 bp from pter
- Size:
- 17,069 bases
- Orientation:
- Plus strand
Genomic View for DYRK2 Gene
Genes around DYRK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q15 by Ensembl
- 12q15 by Entrez Gene
- 12q15 by HGNC
DYRK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DYRK2 Gene
Proteins for DYRK2 Gene
-
Protein details for DYRK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92630-DYRK2_HUMAN
- Recommended name:
- Dual specificity tyrosine-phosphorylation-regulated kinase 2
- Protein Accession:
- Q92630
- B2R9V9
- Q9BRB5
Protein attributes for DYRK2 Gene
- Size:
- 601 amino acids
- Molecular mass:
- 66652 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and VPRBP. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
- SequenceCaution:
-
- Sequence=CAA73885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for DYRK2 Gene
Protein Expression for DYRK2 Gene
Selected DME Specific Peptides for DYRK2 Gene
- Q92630:
-
- PGEDEGDQLACM
- VRNEKRFHRQA
- GGPNNGGYDD
- KVIDFGSSC
- LYELIKKN
- IGKGSFGQV
- HPWLRRRLP
- NAKKRQG
- TFELLSMNLY
Post-translational modifications for DYRK2 Gene
- Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
- Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for DYRK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DYRK2 (DYRK2)
- Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)
-
Custom Antibody ServicesOriGene Antibodies for DYRK2
- Novus Biologicals Antibodies for DYRK2
- Invitrogen Antibodies for DYRK2
- antibodies-online Antibodies for DYRK2: See all 86
- GeneTex DYRK2 antibody for DYRK2
-
Custom Antibody ServicesProSci Antibodies for DYRK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2
Protein Products
- EMD Millipore Purified and/or Recombinant DYRK2 Protein
-
OriGene Purified Proteins for DYRK2
- Search Origene for MassSpec and Protein Over-expression Lysates for DYRK2
- Origene Custom Protein Services for DYRK2
- Novus Biologicals proteins for DYRK2
- antibodies-online Proteins for DYRK2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for DYRK2
Assay Products
Domains & Families for DYRK2 Gene
Gene Families for DYRK2 Gene
Protein Domains for DYRK2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DYRK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92630UniProtKB/Swiss-Prot:
DYRK2_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Function for DYRK2 Gene
Molecular function for DYRK2 Gene
- GENATLAS Biochemistry:
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2,phosphorylating histone H2B
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Inhibited by acridine analogs, purvalanol, and barely by harmine. Inhibited by leucettine and leucettine derivatives.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
- UniProtKB/Swiss-Prot Induction:
- Accumulates in nucleus upon DNA damage. Induced in both esophageal and lung adenocarcinomas.
Enzyme Numbers (IUBMB) for DYRK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 9748265 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | -- |
Phenotypes for DYRK2 Gene
- GenomeRNAi human phenotypes for DYRK2:
-
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased IL-8 secretion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Increased cell viability after pRB stimulation
- Increased mitotic index
- Increased cell migration
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Upregulation of NF-kappaB pathway after LMP1 stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for DYRK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for DYRK2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- Search ViGene Biosciences for DYRK2
CRISPR Products
-
OriGene CRISPR knockouts for DYRK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
miRNA for DYRK2 Gene
- miRTarBase miRNAs that target DYRK2
-
- hsa-mir-103a-3p (MIRT027110)
- hsa-mir-98-5p (MIRT027686)
- hsa-mir-93-5p (MIRT028150)
- hsa-mir-484 (MIRT041925)
- hsa-mir-378a-3p (MIRT043899)
- hsa-mir-197-3p (MIRT048134)
- hsa-mir-196a-5p (MIRT048265)
- hsa-let-7e-5p (MIRT051470)
- hsa-let-7f-5p (MIRT054391)
- hsa-mir-24-3p (MIRT054393)
- hsa-mir-1252-3p (MIRT066578)
- hsa-mir-6869-5p (MIRT066582)
- hsa-mir-590-3p (MIRT066654)
- hsa-mir-297 (MIRT066657)
- hsa-mir-3160-3p (MIRT066658)
- hsa-mir-3924 (MIRT066659)
- hsa-mir-4775 (MIRT066661)
- hsa-mir-8077 (MIRT066663)
- hsa-mir-107 (MIRT066664)
- hsa-mir-187-3p (MIRT066665)
- hsa-mir-382-5p (MIRT066666)
- hsa-mir-495-5p (MIRT066667)
- hsa-mir-744-3p (MIRT066668)
- hsa-mir-4704-3p (MIRT066669)
- hsa-mir-6504-3p (MIRT066670)
- hsa-mir-6767-3p (MIRT066671)
- hsa-mir-193a-3p (MIRT066673)
- hsa-mir-193b-3p (MIRT066674)
- hsa-mir-17-5p (MIRT188182)
- hsa-mir-20a-5p (MIRT188183)
- hsa-mir-106a-5p (MIRT188184)
- hsa-mir-106b-5p (MIRT188187)
- hsa-mir-20b-5p (MIRT188188)
- hsa-mir-526b-3p (MIRT188189)
- hsa-mir-519d-3p (MIRT188190)
- hsa-mir-3609 (MIRT188193)
- hsa-mir-548ah-5p (MIRT188194)
- hsa-mir-4796-3p (MIRT188195)
- hsa-mir-30c-2-3p (MIRT241913)
- hsa-mir-30b-3p (MIRT241914)
- hsa-mir-30c-1-3p (MIRT241916)
- hsa-mir-496 (MIRT241917)
- hsa-mir-887-5p (MIRT241918)
- hsa-mir-3662 (MIRT241919)
- hsa-mir-3689a-3p (MIRT241920)
- hsa-mir-3689b-3p (MIRT241921)
- hsa-mir-3689c (MIRT241922)
- hsa-mir-5701 (MIRT241924)
- hsa-mir-6779-5p (MIRT241925)
- hsa-mir-6780a-5p (MIRT241926)
- hsa-mir-6788-5p (MIRT241927)
- hsa-mir-1273h-5p (MIRT241928)
- hsa-mir-3941 (MIRT248671)
- hsa-mir-8485 (MIRT248673)
- ebv-mir-bart7-3p (MIRT440758)
- hsa-mir-5010-3p (MIRT477854)
- hsa-mir-2113 (MIRT477855)
- hsa-mir-210-3p (MIRT477856)
- hsa-mir-4665-5p (MIRT477857)
- hsa-mir-147b (MIRT477858)
- hsa-mir-1275 (MIRT477859)
- hsa-mir-4472 (MIRT477860)
- hsa-mir-4447 (MIRT477861)
- hsa-mir-92a-2-5p (MIRT477862)
- hsa-mir-5010-5p (MIRT477863)
- hsa-mir-4525 (MIRT477864)
- hsa-mir-7111-5p (MIRT477865)
- hsa-mir-6870-5p (MIRT477866)
- hsa-mir-4723-5p (MIRT477867)
- hsa-mir-5698 (MIRT477868)
- hsa-mir-625-5p (MIRT477869)
- hsa-mir-6739-5p (MIRT477870)
- hsa-mir-6733-5p (MIRT477871)
- hsa-mir-3153 (MIRT477872)
- hsa-mir-4746-3p (MIRT477873)
- hsa-mir-6786-5p (MIRT477874)
- hsa-mir-4328 (MIRT477875)
- hsa-mir-548b-3p (MIRT477876)
- hsa-mir-629-5p (MIRT537893)
- hsa-mir-4686 (MIRT537894)
- hsa-mir-5047 (MIRT537895)
- hsa-mir-1301-3p (MIRT537896)
- hsa-mir-7156-3p (MIRT537897)
- hsa-mir-603 (MIRT537898)
- hsa-mir-362-3p (MIRT537899)
- hsa-mir-329-3p (MIRT537900)
- hsa-mir-101-3p (MIRT537901)
- hsa-mir-509-3p (MIRT537902)
- hsa-mir-4717-3p (MIRT537903)
- hsa-mir-411-3p (MIRT537904)
- hsa-mir-379-3p (MIRT537905)
- hsa-mir-4461 (MIRT537906)
- hsa-mir-670-5p (MIRT542994)
- hsa-mir-4732-3p (MIRT542995)
- hsa-mir-345-3p (MIRT542996)
- hsa-mir-545-5p (MIRT542997)
- hsa-mir-3613-3p (MIRT542998)
- hsa-mir-125a-5p (MIRT542999)
- hsa-mir-125b-5p (MIRT543000)
- hsa-mir-4319 (MIRT543001)
- hsa-mir-3912-5p (MIRT558249)
- hsa-mir-567 (MIRT558250)
- hsa-mir-4487 (MIRT558251)
- hsa-mir-558 (MIRT558252)
- hsa-mir-6834-3p (MIRT558253)
- hsa-mir-7849-3p (MIRT558254)
- hsa-mir-4786-5p (MIRT704078)
- hsa-mir-1288-5p (MIRT704079)
- hsa-mir-195-3p (MIRT704080)
- hsa-mir-16-2-3p (MIRT704081)
- hsa-mir-383-5p (MIRT704082)
- hsa-mir-4523 (MIRT704083)
- hsa-mir-548ay-3p (MIRT704084)
- hsa-mir-548at-3p (MIRT704085)
- hsa-mir-548as-3p (MIRT704086)
- hsa-mir-548t-3p (MIRT704087)
- hsa-mir-548ap-3p (MIRT704088)
- hsa-mir-548aa (MIRT704089)
- hsa-mir-582-5p (MIRT708147)
miRNA Products
- Search ViGene Biosciences for DYRK2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DYRK2
- Browse OriGene Inhibitory RNA Products For DYRK2
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
Clone Products
- Sino Biological Human cDNA Clone for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for DYRK2
- VectorBuilder custom plasmid, inducible vectors for DYRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for DYRK2
-
ViGene Biosciences adenoviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYRK2 Gene
Localization for DYRK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DYRK2 Gene
- Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 19287380 |
| GO:0005634 | nucleus | IDA,IEA | 17349958 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,TAS | 17349958 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for DYRK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of TP53 Activity | ||
| 2 | Gene Expression |
.48
|
|
| 3 | DNA Damage | ||
| 4 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 5 | p53 pathway (Pathway Interaction Database) | ||
Pathways by source for DYRK2 Gene
1 Cell Signaling Technology pathway for DYRK2 Gene
2 BioSystems pathways for DYRK2 Gene
5 Reactome pathways for DYRK2 Gene
1 GeneGo (Thomson Reuters) pathway for DYRK2 Gene
Interacting Proteins for DYRK2 Gene
Selected Interacting proteins:
ENSP00000342105
Q92630-DYRK2_HUMAN
for DYRK2 Gene via
STRING
IID
UniProtKB
SIGNOR curated interactions for DYRK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA,TAS | 11311121 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEP | 19965871 |
| GO:0007224 | smoothened signaling pathway | IMP | 18455992 |
| GO:0016310 | phosphorylation | IEA | -- |
Drugs & Compounds for DYRK2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(1) ApexBio Compounds for DYRK2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ID-8 | 147591-46-6 |
Drug Products
- ApexBio compounds for DYRK2
Transcripts for DYRK2 Gene
mRNA/cDNA for DYRK2 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DYRK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DYRK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
miRNA Products
- Search ViGene Biosciences for DYRK2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DYRK2
- Browse OriGene Inhibitory RNA Products For DYRK2
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
Clone Products
- Sino Biological Human cDNA Clone for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for DYRK2
- VectorBuilder custom plasmid, inducible vectors for DYRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | - | - | ||||||||||||
| SP4: | - |
Expression for DYRK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Adipocyte (63.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYRK2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DYRK2 Gene:
DYRK2SOURCE GeneReport for Unigene cluster for DYRK2 Gene:
Hs.173135mRNA Expression by UniProt/SwissProt for DYRK2 Gene:
Q92630-DYRK2_HUMAN
Tissue specificity:
Testis, after the onset of spermatogenesis.
Evidence on tissue expression from TISSUES for DYRK2 Gene
- Nervous system(4.7)
- Muscle(4.3)
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for DYRK2
-
OriGene qPCR primer pairs for DYRK2
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK2 Gene
Orthologs for DYRK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DYRK2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | DYRK2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | DYRK2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Dyrk2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dyrk2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DYRK2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DYRK2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DYRK2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dyrk2 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4918 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dyrk2 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008241 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dyrk3 36 34 35 |
|
||
| smi35A 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | mbk-2 36 34 35 |
|
||
| C36B7.2 36 |
|
|
|||
| C36B7.1 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06638 34 |
|
- Species where no ortholog for DYRK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DYRK2 Gene
Paralogs for DYRK2 Gene
(7) SIMAP similar genes for DYRK2 Gene using alignment to 5 proteins:
Variants for DYRK2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040459 | A glioblastoma multiforme sample | ||||
| rs1000225280 | -- | 67,647,477(+) | CCTTC(C/G)GACTG | upstream-variant-2KB | |
| rs1000252230 | -- | 67,653,159(+) | ACACA(C/G)TGTGC | intron-variant | |
| rs1000316208 | -- | 67,649,566(+) | CCCGC(C/T)GGGTC | intron-variant, upstream-variant-2KB | |
| rs1000946321 | -- | 67,664,681(+) | GGGGG(A/G)AAGTT | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1143702 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.54;
29.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for DYRK2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DYRK2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK2 Gene
Disorders for DYRK2 Gene
Relevant External Links for DYRK2
No disorders were found for DYRK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK2 Gene
Publications for DYRK2 Gene
- DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (PMID: 17349958) Taira N. … Yoshida K. (Mol. Cell 2007) 3 4 22 64
- Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4 64
- Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. (PMID: 23362280) Jung H.Y. … Park J.I. (J. Biol. Chem. 2013) 3 4 64
- DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PMID: 22307329) Taira N. … Yoshida K. (J. Clin. Invest. 2012) 3 4 64
- Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. (PMID: 22878263) Perez M. … Calzado M.A. (J. Mol. Cell Biol. 2012) 3 4 64
Products for DYRK2 Gene
- R&D Systems Antibodies for DYRK2 (DYRK2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for DYRK2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DYRK2
- Search Origene for MassSpec and Protein Over-expression Lysates for DYRK2
- Origene Custom Protein Services for DYRK2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DYRK2
- Browse OriGene Inhibitory RNA Products For DYRK2
- OriGene qPCR primer pairs and template standards for DYRK2
- OriGene qPCR primer pairs for DYRK2
- OriGene CRISPR knockouts for DYRK2
- OriGene ORF clones in human for DYRK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DYRK2
- GenScript: Next-day shipping cDNA ORF clone for DYRK2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DYRK2
- GenScript Custom Assay Services for DYRK2
- GenScript Custom overexpressing Cell Line Services for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DYRK2
- Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for DYRK2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for DYRK2
- Novus Biologicals proteins for DYRK2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for DYRK2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for DYRK2
- Addgene plasmids for DYRK2
- antibodies-online Antibodies for DYRK2: See all 86
- Search antibodies-online for kits
- antibodies-online Proteins for DYRK2: See all 5
- Search antibodies-online for peptides
- GeneTex DYRK2 antibody for DYRK2
- Search GeneTex for Proteins for DYRK2
- ViGene Biosciences adenoviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- Search ViGene Biosciences for DYRK2
- Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2
- Search Santa Cruz Biotechnology (SCBT) for DYRK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- Custom Antibody ServicesProSci Antibodies for DYRK2
- Search for DYRK2 Proteins at ProSci
- Horizon Cell Lines for DYRK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for DYRK2
- VectorBuilder custom plasmid, inducible vectors for DYRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DYRK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer