Aliases for DYRK2 Gene
Aliases for DYRK2 Gene
External Ids for DYRK2 Gene
- HGNC: 3093
- Entrez Gene: 8445
- Ensembl: ENSG00000127334
- OMIM: 603496
- UniProtKB: Q92630
Previous GeneCards Identifiers for DYRK2 Gene
- GC12P067846
- GC12P067759
- GC12P066329
- GC12P066328
- GC12P068042
- GC12P065093
Summaries for DYRK2 Gene
-
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
GeneCards Summary for DYRK2 Gene
DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is HIPK4.
UniProtKB/Swiss-Prot for DYRK2 Gene
-
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK2 Gene
Genomics for DYRK2 Gene
Regulatory Elements for DYRK2 Gene
Enhancers for DYRK2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around DYRK2 on UCSC Golden Path with GeneCards custom track
Promoters for DYRK2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around DYRK2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for DYRK2 Gene
- Chromosome:
- 12
- Start:
- 67,648,338 bp from pter
- End:
- 67,665,406 bp from pter
- Size:
- 17,069 bases
- Orientation:
- Plus strand
Genomic View for DYRK2 Gene
Genes around DYRK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q15 by Ensembl
- 12q15 by Entrez Gene
- 12q15 by HGNC
DYRK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DYRK2 Gene
Proteins for DYRK2 Gene
-
Protein details for DYRK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92630-DYRK2_HUMAN
- Recommended name:
- Dual specificity tyrosine-phosphorylation-regulated kinase 2
- Protein Accession:
- Q92630
- B2R9V9
- Q9BRB5
Protein attributes for DYRK2 Gene
- Size:
- 601 amino acids
- Molecular mass:
- 66652 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Component of an E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and VPRBP. Interacts with SIAH2 and MDM2. Interacts with MAP3K10 and NFATC1. May also interact with CCNL2.
- SequenceCaution:
-
- Sequence=CAA73885.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DYRK2 Gene
Selected DME Specific Peptides for DYRK2 Gene
Post-translational modifications for DYRK2 Gene
- Autophosphorylates cotranslationally on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop, but once mature, does not have any protein tyrosine kinase activity. Phosphorylated at Thr-106 and Ser-442 by ATM in response to genotoxic stress.
- Under normal conditions, polyubiquitinated in the nucleus by MDM2, leading to its proteasomal degradation. Phosphorylation on Thr-106 and Ser-442 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasomal degradation. Polyubiquitinated by SIAH2, leading to its proteasomal degradation. Polyubiquitinated by SIAH2 occurs under normal conditions, and is enhanced in response to hypoxia.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for DYRK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DYRK2 (DYRK2)
- Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)
- Novus Biologicals Antibodies for DYRK2
- Invitrogen Antibodies for DYRK2
- antibodies-online Antibodies for DYRK2: See all 86
- GeneTex DYRK2 antibody for DYRK2
-
Custom Antibody ServicesProSci Antibodies for DYRK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2
Protein Products
- EMD Millipore Purified and/or Recombinant DYRK2 Protein
-
OriGene Purified Proteins for DYRK2
- Search Origene for MassSpec and Protein Over-expression Lysates for DYRK2
- Origene Custom Protein Services for DYRK2
- Novus Biologicals proteins for DYRK2
- antibodies-online Proteins for DYRK2: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for DYRK2
Assay Products
Domains & Families for DYRK2 Gene
Gene Families for DYRK2 Gene
Protein Domains for DYRK2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DYRK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92630UniProtKB/Swiss-Prot:
DYRK2_HUMAN :- Contains 1 protein kinase domain.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
- Domain:
-
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Function for DYRK2 Gene
Molecular function for DYRK2 Gene
- GENATLAS Biochemistry:
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2,phosphorylating histone H2B
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by autophosphorylation on the second tyrosine residue in the Tyr-X-Tyr motif in the activation loop. Inhibited by acridine analogs, purvalanol, and barely by harmine. Inhibited by leucettine and leucettine derivatives.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at Ser-46, and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at Ser-457, promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro).
- UniProtKB/Swiss-Prot Induction:
- Accumulates in nucleus upon DNA damage. Induced in both esophageal and lung adenocarcinomas.
Enzyme Numbers (IUBMB) for DYRK2 Gene
- EC 2.7.12.1 63 4
- EC 2.7.12 63
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 9748265 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | -- |
| GO:0005524 | ATP binding | IEA,IDA | 11311121 |
| GO:0030145 | manganese ion binding | IDA | 9748265 |
Phenotypes for DYRK2 Gene
- GenomeRNAi human phenotypes for DYRK2:
-
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Increased cell viability after pRB stimulation
- Increased mitotic index
- Increased cell migration
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Upregulation of NF-kappaB pathway after LMP1 stimulation
Animal Model Products
-
Taconic Biosciences Mouse Models for DYRK2
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- Search ViGene Biosciences for DYRK2
CRISPR Products
-
OriGene CRISPR knockouts for DYRK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
miRNA for DYRK2 Gene
- miRTarBase miRNAs that target DYRK2
-
- hsa-mir-103a-3p (MIRT027110)
- hsa-mir-98-5p (MIRT027686)
- hsa-mir-93-5p (MIRT028150)
- hsa-mir-484 (MIRT041925)
- hsa-mir-378a-3p (MIRT043899)
- hsa-mir-197-3p (MIRT048134)
- hsa-mir-196a-5p (MIRT048265)
- hsa-let-7e-5p (MIRT051470)
- hsa-let-7f-5p (MIRT054391)
- hsa-mir-24-3p (MIRT054393)
- hsa-mir-1252-3p (MIRT066578)
- hsa-mir-6869-5p (MIRT066582)
- hsa-mir-590-3p (MIRT066654)
- hsa-mir-297 (MIRT066657)
- hsa-mir-3160-3p (MIRT066658)
- hsa-mir-3924 (MIRT066659)
- hsa-mir-4775 (MIRT066661)
- hsa-mir-8077 (MIRT066663)
- hsa-mir-107 (MIRT066664)
- hsa-mir-187-3p (MIRT066665)
- hsa-mir-382-5p (MIRT066666)
- hsa-mir-495-5p (MIRT066667)
- hsa-mir-744-3p (MIRT066668)
- hsa-mir-4704-3p (MIRT066669)
- hsa-mir-6504-3p (MIRT066670)
- hsa-mir-6767-3p (MIRT066671)
- hsa-mir-193a-3p (MIRT066673)
- hsa-mir-193b-3p (MIRT066674)
- hsa-mir-17-5p (MIRT188182)
- hsa-mir-20a-5p (MIRT188183)
- hsa-mir-106a-5p (MIRT188184)
- hsa-mir-106b-5p (MIRT188187)
- hsa-mir-20b-5p (MIRT188188)
- hsa-mir-526b-3p (MIRT188189)
- hsa-mir-519d-3p (MIRT188190)
- hsa-mir-3609 (MIRT188193)
- hsa-mir-548ah-5p (MIRT188194)
- hsa-mir-4796-3p (MIRT188195)
- hsa-mir-30c-2-3p (MIRT241913)
- hsa-mir-30b-3p (MIRT241914)
- hsa-mir-30c-1-3p (MIRT241916)
- hsa-mir-496 (MIRT241917)
- hsa-mir-887-5p (MIRT241918)
- hsa-mir-3662 (MIRT241919)
- hsa-mir-3689a-3p (MIRT241920)
- hsa-mir-3689b-3p (MIRT241921)
- hsa-mir-3689c (MIRT241922)
- hsa-mir-5701 (MIRT241924)
- hsa-mir-6779-5p (MIRT241925)
- hsa-mir-6780a-5p (MIRT241926)
- hsa-mir-6788-5p (MIRT241927)
- hsa-mir-1273h-5p (MIRT241928)
- hsa-mir-3941 (MIRT248671)
- hsa-mir-8485 (MIRT248673)
- ebv-mir-bart7-3p (MIRT440758)
- hsa-mir-5010-3p (MIRT477854)
- hsa-mir-2113 (MIRT477855)
- hsa-mir-210-3p (MIRT477856)
- hsa-mir-4665-5p (MIRT477857)
- hsa-mir-147b (MIRT477858)
- hsa-mir-1275 (MIRT477859)
- hsa-mir-4472 (MIRT477860)
- hsa-mir-4447 (MIRT477861)
- hsa-mir-92a-2-5p (MIRT477862)
- hsa-mir-5010-5p (MIRT477863)
- hsa-mir-4525 (MIRT477864)
- hsa-mir-7111-5p (MIRT477865)
- hsa-mir-6870-5p (MIRT477866)
- hsa-mir-4723-5p (MIRT477867)
- hsa-mir-5698 (MIRT477868)
- hsa-mir-625-5p (MIRT477869)
- hsa-mir-6739-5p (MIRT477870)
- hsa-mir-6733-5p (MIRT477871)
- hsa-mir-3153 (MIRT477872)
- hsa-mir-4746-3p (MIRT477873)
- hsa-mir-6786-5p (MIRT477874)
- hsa-mir-4328 (MIRT477875)
- hsa-mir-548b-3p (MIRT477876)
- hsa-mir-629-5p (MIRT537893)
- hsa-mir-4686 (MIRT537894)
- hsa-mir-5047 (MIRT537895)
- hsa-mir-1301-3p (MIRT537896)
- hsa-mir-7156-3p (MIRT537897)
- hsa-mir-603 (MIRT537898)
- hsa-mir-362-3p (MIRT537899)
- hsa-mir-329-3p (MIRT537900)
- hsa-mir-101-3p (MIRT537901)
- hsa-mir-509-3p (MIRT537902)
- hsa-mir-4717-3p (MIRT537903)
- hsa-mir-411-3p (MIRT537904)
- hsa-mir-379-3p (MIRT537905)
- hsa-mir-4461 (MIRT537906)
- hsa-mir-670-5p (MIRT542994)
- hsa-mir-4732-3p (MIRT542995)
- hsa-mir-345-3p (MIRT542996)
- hsa-mir-545-5p (MIRT542997)
- hsa-mir-3613-3p (MIRT542998)
- hsa-mir-125a-5p (MIRT542999)
- hsa-mir-125b-5p (MIRT543000)
- hsa-mir-4319 (MIRT543001)
- hsa-mir-3912-5p (MIRT558249)
- hsa-mir-567 (MIRT558250)
- hsa-mir-4487 (MIRT558251)
- hsa-mir-558 (MIRT558252)
- hsa-mir-6834-3p (MIRT558253)
- hsa-mir-7849-3p (MIRT558254)
- hsa-mir-4786-5p (MIRT704078)
- hsa-mir-1288-5p (MIRT704079)
- hsa-mir-195-3p (MIRT704080)
- hsa-mir-16-2-3p (MIRT704081)
- hsa-mir-383-5p (MIRT704082)
- hsa-mir-4523 (MIRT704083)
- hsa-mir-548ay-3p (MIRT704084)
- hsa-mir-548at-3p (MIRT704085)
- hsa-mir-548as-3p (MIRT704086)
- hsa-mir-548t-3p (MIRT704087)
- hsa-mir-548ap-3p (MIRT704088)
- hsa-mir-548aa (MIRT704089)
- hsa-mir-582-5p (MIRT708147)
miRNA Products
- Search ViGene Biosciences for DYRK2
Clone Products
- OriGene clones in human for DYRK2
- OriGene ORF clones in human,mouse,rat for DYRK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for DYRK2
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYRK2 Gene
Localization for DYRK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DYRK2 Gene
- Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| mitochondrion | 2 |
No data available for Gene Ontology (GO) - Cellular Components for DYRK2 Gene
Pathways & Interactions for DYRK2 Gene
More details on SuperPathways for DYRK2| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of TP53 Activity | ||
| 2 | Gene Expression |
.49
|
|
| 3 | DNA Damage | ||
| 4 | Translation Insulin regulation of translation | ||
| 5 | p53 pathway (Pathway Interaction Database) |
Pathways by source for DYRK2 Gene
1 Cell Signaling Technology pathway for DYRK2 Gene
1 BioSystems pathway for DYRK2 Gene
5 Reactome pathways for DYRK2 Gene
1 GeneGo (Thomson Reuters) pathway for DYRK2 Gene
Interacting Proteins for DYRK2 Gene
Selected Interacting proteins:
Q92630-DYRK2_HUMAN
ENSP00000342105
for DYRK2 Gene via
MINT
STRING
UniProtKB
I2D
SIGNOR curated interactions for DYRK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA,IDA | 11311121 |
| GO:0045725 | positive regulation of glycogen biosynthetic process | IDA | 11311121 |
| GO:0051534 | negative regulation of NFAT protein import into nucleus | IMP | 16511445 |
Drugs & Compounds for DYRK2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(1) ApexBio Compounds for DYRK2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ID-8 | 147591-46-6 |
Drug Products
- ApexBio compounds for DYRK2
Transcripts for DYRK2 Gene
mRNA/cDNA for DYRK2 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DYRK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DYRK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- GenScript: Design CRISPR guide RNA sequences for DYRK2
miRNA Products
- Search ViGene Biosciences for DYRK2
Clone Products
- OriGene clones in human for DYRK2
- OriGene ORF clones in human,mouse,rat for DYRK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for DYRK2
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | - | - | ||||||||||||
| SP4: | - |
Expression for DYRK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Adipocyte (63.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYRK2 Gene
SOURCE GeneReport for Unigene cluster for DYRK2 Gene Hs.173135
mRNA Expression by UniProt/SwissProt for DYRK2 Gene
Q92630-DYRK2_HUMAN
Tissue specificity:
Testis, after the onset of spermatogenesis.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for DYRK2
-
OriGene qPCR primer pairs for DYRK2
No data available for mRNA differential expression in normal tissues for DYRK2 Gene
Orthologs for DYRK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | DYRK2 35 |
|
||
| DYRK2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | DYRK2 35 |
|
||
| DYRK2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Dyrk2 35 |
|
||
| Dyrk2 16 |
|
||||
| Dyrk2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | DYRK2 35 |
|
||
| DYRK2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Dyrk2 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DYRK2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DYRK2 35 |
|
||
| DYRK2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | DYRK2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dyrk2 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.4918 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dyrk2 35 |
|
||
| dyrk2 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Dyrk3 37 |
|
|
|
| smi35A 37 |
|
|
|||
| Dyrk3 35 |
|
||||
| Dyrk3 36 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008241 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C36B7.1 37 |
|
|
|
| C36B7.2 37 |
|
|
|||
| mbk-2 37 |
|
|
|||
| mbk-2 35 |
|
||||
| mbk-2 36 |
|
OneToMany | |||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06638 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for DYRK2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DYRK2 Gene
Paralogs for DYRK2 Gene
(7) SIMAP similar genes for DYRK2 Gene using alignment to 5 proteins:
Variants for DYRK2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs35139851 | - | 67,657,199(+) | ATAAC(A/G)GTAAC | reference, missense | |
| VAR_040459 | A glioblastoma multiforme sample | ||||
| rs34166200 | - | 67,657,640(+) | AAGTC(A/C)ACCAG | reference, missense | |
| rs56293072 | - | 67,657,791(+) | CCGCA(A/G)CCACA | reference, missense | |
| rs35688869 | - | 67,658,259(+) | CAAAC(A/G)AGCCA | reference, missense |
Residual Variation Intolerance Score:
8.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.54;
29.92% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DYRK2 Gene
Disorders for DYRK2 Gene
Relevant External Links for DYRK2
No disorders were found for DYRK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYRK2 Gene
Publications for DYRK2 Gene
- Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. (PMID: 9748265) Becker W. … Joost H.-G. (J. Biol. Chem. 1998) 2 3 4 67
- DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. (PMID: 17349958) Taira N. … Yoshida K. (Mol. Cell 2007) 3 23
- DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma. (PMID: 25712377) Yamaguchi N. … Yoshida K. (Tumour Biol. 2015) 3
- Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2. (PMID: 24438055) Ong S.S. … Chen T. (Biochem. J. 2014) 3
- Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer. (PMID: 25095982) Enomoto Y. … Iwasaki A. (Tumour Biol. 2014) 3
Products for DYRK2 Gene
- R&D Systems Antibodies for DYRK2 (DYRK2)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DYRK2
- Search Origene for MassSpec and Protein Over-expression Lysates for DYRK2
- Origene Custom Protein Services for DYRK2
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for DYRK2
- Browse OriGene Inhibitory RNA Products For DYRK2
- OriGene qPCR primer pairs for DYRK2
- OriGene qPCR primer pairs and template standards for DYRK2
- OriGene CRISPR knockouts for DYRK2
- OriGene clones in human for DYRK2
- OriGene ORF clones in human,mouse,rat for DYRK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for DYRK2
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- GenScript: Design CRISPR guide RNA sequences for DYRK2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for DYRK2
- Cell Signaling Technology (CST) Antibodies for DYRK2 (DYRK2)
- Search for Antibodies & Assays
- Novus Biologicals Antibodies for DYRK2
- Novus Biologicals proteins for DYRK2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for DYRK2
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for DYRK2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for DYRK2
- Addgene plasmids for DYRK2
- antibodies-online Antibodies for DYRK2: See all 86
- Search antibodies-online for kits
- antibodies-online Proteins for DYRK2: See all 5
- Search antibodies-online for peptides
- GeneTex DYRK2 antibody for DYRK2
- Search GeneTex for Proteins for DYRK2
- ViGene Biosciences adenoviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DYRK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DYRK2 gene
- Search ViGene Biosciences for DYRK2
- Search ViGene Biosciences for DYRK2
- Santa Cruz Biotechnology (SCBT) Antibodies for DYRK2
- Search Santa Cruz Biotechnology (SCBT) for DYRK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DYRK2
- Custom Antibody ServicesProSci Antibodies for DYRK2
Sources for DYRK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon