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Aliases for DYRK1B Gene

Aliases for DYRK1B Gene

  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2 3
  • Minibrain-Related Kinase 2 3 4
  • MIRK 3 4 6
  • Mirk Protein Kinase 3 4
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B 3
  • EC 2.7.12.1 4
  • EC 2.7.12 64
  • AOMS3 3

External Ids for DYRK1B Gene

Summaries for DYRK1B Gene

Entrez Gene Summary for DYRK1B Gene

  • This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DYRK1B Gene

DYRK1B (Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include abdominal obesity-metabolic syndrome 3. Among its related pathways are Glucose / Energy Metabolism and Neuroscience. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is HIPK4.

UniProtKB/Swiss-Prot for DYRK1B Gene

  • Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Gene Wiki entry for DYRK1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK1B Gene

Genomics for DYRK1B Gene

Genomic Location for DYRK1B Gene

Start:
39,825,350 bp from pter
End:
39,834,201 bp from pter
Size:
8,852 bases
Orientation:
Minus strand

Genomic View for DYRK1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYRK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK1B Gene

Regulatory Elements for DYRK1B Gene

Transcription factor binding sites by QIAGEN in the DYRK1B gene promoter:

Proteins for DYRK1B Gene

  • Protein details for DYRK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y463-DYR1B_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Protein Accession:
    Q9Y463
    Secondary Accessions:
    • O75258
    • O75788
    • O75789

    Protein attributes for DYRK1B Gene

    Size:
    629 amino acids
    Molecular mass:
    69198 Da
    Quaternary structure:
    • Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
    SequenceCaution:
    • Sequence=AAC28914.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK1B Gene

Proteomics data for DYRK1B Gene at MOPED

Post-translational modifications for DYRK1B Gene

  • Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys256

Domains for DYRK1B Gene

UniProtKB/Swiss-Prot:

DYR1B_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9Y463
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.:
    • Q9Y463
genes like me logo Genes that share domains with DYRK1B: view

Function for DYRK1B Gene

Molecular function for DYRK1B Gene

GENATLAS Biochemistry: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse homolog,expressed in muscle and testis,involved in the regulation of nuclear functions
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by RANBP9
UniProtKB/Swiss-Prot Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Enzyme Numbers (IUBMB) for DYRK1B Gene

Gene Ontology (GO) - Molecular Function for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11980910
GO:0004672 protein kinase activity IDA 11980910
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK1B: view

Phenotypes for DYRK1B Gene

genes like me logo Genes that share phenotypes with DYRK1B: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DYRK1B Gene

Localization for DYRK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYRK1B Gene COMPARTMENTS Subcellular localization image for DYRK1B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DYRK1B: view

Pathways for DYRK1B Gene

genes like me logo Genes that share pathways with DYRK1B: view

Pathways by source for DYRK1B Gene

3 Cell Signaling Technology pathways for DYRK1B Gene

Gene Ontology (GO) - Biological Process for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11980910
GO:0007520 myoblast fusion IEA --
GO:0008152 metabolic process --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 11980910
genes like me logo Genes that share ontologies with DYRK1B: view

Compounds for DYRK1B Gene

(2) HMDB Compounds for DYRK1B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(4) Novoseek inferred chemical compound relationships for DYRK1B Gene

Compound -log(P) Hits PubMed IDs
threonine 57.4 3
serine 54.5 3
tyrosine 36.5 3
phosphatidylinositol 35.6 2
genes like me logo Genes that share compounds with DYRK1B: view

Transcripts for DYRK1B Gene

Unigene Clusters for DYRK1B Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1B Gene

No ASD Table

Relevant External Links for DYRK1B Gene

GeneLoc Exon Structure for
DYRK1B
ECgene alternative splicing isoforms for
DYRK1B

Expression for DYRK1B Gene

mRNA expression in normal human tissues for DYRK1B Gene

mRNA differential expression in normal tissues according to GTEx for DYRK1B Gene

This gene is overexpressed in Muscle - Skeletal (6.6) and Testis (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYRK1B Gene

SOURCE GeneReport for Unigene cluster for DYRK1B Gene Hs.130988

mRNA Expression by UniProt/SwissProt for DYRK1B Gene

Q9Y463-DYR1B_HUMAN
Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
genes like me logo Genes that share expressions with DYRK1B: view

Orthologs for DYRK1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK1B 36
  • 99.74 (n)
  • 100 (a)
DYRK1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK1B 36
  • 94.01 (n)
  • 98.73 (a)
DYRK1B 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYRK1B 36
  • 95.5 (n)
  • 98.89 (a)
DYRK1B 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dyrk1b 36
  • 92.63 (n)
  • 97.3 (a)
Dyrk1b 16
Dyrk1b 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYRK1B 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK1B 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk1b 36
  • 92.76 (n)
  • 97.45 (a)
lizard
(Anolis carolinensis)
Reptilia DYRK1B 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk1a.2 36
  • 70.15 (n)
  • 79.5 (a)
zebrafish
(Danio rerio)
Actinopterygii dyrk1b 36
  • 73.95 (n)
  • 76.65 (a)
dyrk1b 37
  • 56 (a)
OneToOne
psmb6 36
fruit fly
(Drosophila melanogaster)
Insecta mnb 37
  • 36 (a)
OneToMany
mnb 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-1 37
  • 32 (a)
OneToMany
mbk-1 38
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 37
  • 19 (a)
OneToMany
YAK1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1202 37
  • 73 (a)
OneToMany
Species with no ortholog for DYRK1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK1B Gene

ENSEMBL:
Gene Tree for DYRK1B (if available)
TreeFam:
Gene Tree for DYRK1B (if available)

Paralogs for DYRK1B Gene

Paralogs for DYRK1B Gene

Selected SIMAP similar genes for DYRK1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DYRK1B: view

Variants for DYRK1B Gene

Sequence variations from dbSNP and Humsavar for DYRK1B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2354800 -- 39,833,947(-) CCCGT(A/C)GCCGT intron-variant, upstream-variant-2KB
rs3217031 -- 39,832,108(+) CAATG(-/A)AGAGA intron-variant, utr-variant-5-prime
rs7254914 -- 39,825,201(+) TGCAG(A/C)CTCAT downstream-variant-500B
rs11547645 -- 39,825,667(+) CCCCA(A/G)ATGGG utr-variant-3-prime
rs11547646 -- 39,831,810(+) CTGCG(C/T)GTGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DYRK1B Gene

Variant ID Type Subtype PubMed ID
dgv1082e1 CNV Complex 17122850
nsv911696 CNV Loss 21882294
nsv9725 CNV Gain+Loss 18304495

Relevant External Links for DYRK1B Gene

HapMap Linkage Disequilibrium report
DYRK1B
Human Gene Mutation Database (HGMD)
DYRK1B

Disorders for DYRK1B Gene

UniProtKB/Swiss-Prot

DYR1B_HUMAN
  • Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269 PubMed:24827035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) Novoseek inferred disease relationships for DYRK1B Gene

Disease -log(P) Hits PubMed IDs
rhabdomyosarcoma 52.7 9
tumors 10.5 8
cancer 0 4
genes like me logo Genes that share disorders with DYRK1B: view

Publications for DYRK1B Gene

  1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PMID: 9918863) Leder S. … Becker W. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PMID: 10910078) Lee K. … Friedman E. (Cancer Res. 2000) 3 4 23
  3. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. (PMID: 19633423) Gao J. … Haura E.B. (Cancer Biol. Ther. 2009) 3 23
  4. The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling. (PMID: 16257974) Jin K. … Friedman E. (J. Biol. Chem. 2005) 3 23
  5. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (PMID: 16618736) Deng X. … Friedman E. (Cancer Res. 2006) 3 23

Products for DYRK1B Gene

Sources for DYRK1B Gene

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