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DYRK1B Gene

protein-coding GIFtS: 61
GCID: GC19M040316

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B¹ ²		Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B²
Minibrain-Related Kinase¹ ² ³		EC 2.7.12.1³
MIRK² ³ ⁵		EC 2.7.12⁸
Mirk Protein Kinase² ³

External Ids:	HGNC: 3092¹	Entrez Gene: 9149²	Ensembl: ENSG00000105204⁷	OMIM: 604556⁵	UniProtKB: Q9Y463³

Export aliases for DYRK1B gene to outside databases

Previous GC identifers: GC19M040957 GC19M040707 GC19M044992 GC19M045007 GC19M036763

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYRK1B Gene:

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal

and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear

functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced

exons within the catalytic domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for DYRK1B Gene:

DYRK1B (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B) is a protein-coding gene. Diseases associated with DYRK1B include pancreatic ductal adenocarcinoma, and rhabdomyosarcoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463

Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances

the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon

carcinoma cell survival in mitogen-poor environments

Gene Wiki entry for DYRK1B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NT_011109.17 NC_018930.2

Regulatory elements:

Regulatory transcription factor binding sites in the DYRK1B gene promoter:
MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYRK1B promoter sequence

Search Chromatin IP Primers for DYRK1B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYRK1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

DYRK1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK1B gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M040316: view genomic region (about GC identifiers)

Start:	40,315,990 bp from pter	End:	40,324,841 bp from pter
Size:	8,852 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463 (See protein sequence)

Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Size: 629 amino acids; 69198 Da

Subunit: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9,

RAN, DYRK1B and COPS5. Interacts with DCAF7

Sequence caution: Sequence=AAC28914.1; Type=Erroneous gene model prediction;

Secondary accessions: O75258 O75788 O75789

Alternative splicing: 3 isoforms: Q9Y463-1 Q9Y463-2 Q9Y463-3

Explore the universe of human proteins at neXtProt for DYRK1B: NX_Q9Y463

Explore proteomics data for DYRK1B at MOPED

Post-translational modifications:

Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required

for dimerization¹

Ubiquitination² at Lys256

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DYRK1B (Q9Y463) (see all 9)

QAPKARK

NPKRSAIKI

IGKGSFGQV

IVEVLGIPPA

See DYRK1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_004705.1 NP_006474.1 NP_006475.1

ENSEMBL proteins:

ENSP00000469863 ENSP00000312789 ENSP00000472941 ENSP00000403182 ENSP00000471609

ENSP00000472861 ENSP00000221803

DYRK1B Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Dyrk1 subfamily

5 InterPro protein domains:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_dom

Graphical View of Domain Structure for InterPro Entry Q9Y463

ProtoNet protein and cluster: Q9Y463

UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily

Similarity: Contains 1 protein kinase domain

DYRK1B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DYR1B_HUMAN, Q9Y463

Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances

the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon

carcinoma cell survival in mitogen-poor environments

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Inhibited by RANBP9

Genatlas biochemistry entry for DYRK1B:

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse

homolog,expressed in muscle and testis,involved in the regulation of nuclear functions

Enzyme Numbers (IUBMB): EC 2.7.12² EC 2.7.12.1¹

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IDA	11980910
GO:0004672	protein kinase activity	IDA	11980910
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	IEA	--

DYRK1B for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for DYRK1B:

Decreased focal adhesion (FA)

Decreased substrate adherent c

High actin ratio cells

Increased apoptosis

1 MGI phenotypic allele

for Dyrk1b (no phenotypes)

DYRK1B for phenotypes About GeneDecksing

Animal Models:

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miRNA Products:		miRTarBase miRNAs that target DYRK1B: hsa-mir-455-3p (MIRT037892), hsa-mir-30c-1-3p (MIRT038537), hsa-mir-320c (MIRT036171), hsa-mir-149-5p (MIRT045408), hsa-mir-320a (MIRT044780), hsa-mir-324-5p (MIRT043128), hsa-mir-335-5p (MIRT016969)

		Block miRNA regulation of human, mouse, rat DYRK1B using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DYRK1B (see all 28):
		hsa-miR-539 hsa-miR-1263 hsa-miR-148b hsa-miR-15a hsa-miR-765 hsa-miR-503 hsa-miR-3605-5p hsa-miR-511

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DYR1B_HUMAN, Q9Y463: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0043231	intracellular membrane-bounded organelle	--	--

DYRK1B for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DYRK1B About

See pathways by source

SuperPath

Contained pathways About

Neuroscience

Neuroscience

Glucose / Energy Metabolism

Glucose / Energy Metabolism

Apoptosis and Autophagy

Apoptosis and Autophagy

Pathways by source See SuperPaths
Show all pathways

3 Cell Signaling Technology (CST) Pathways for DYRK1B

	Apoptosis and Autophagy
	Neuroscience
	Glucose / Energy Metabolism

DYRK1B for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DYRK1B
Interactions:

GeneGlobe Interaction Network for DYRK1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DYRK1B (Q9Y463^{1, 2, 3} ENSP00000312789⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RANBP9	Q96S59¹^,³, ENSP00000011619⁴	EBI-634187,EBI-636085 I2D: score=5 STRING: ENSP00000011619
HIPK2	Q9H2X6²^,³	MINT-8085067 I2D: score=1
DCAF7	P61962¹^,²^,³, ENSP00000308344⁴	EBI-634187,EBI-359808 MINT-8085204 MINT-8085121 I2D: score=4 STRING: ENSP00000308344
HNF1A	P20823¹^,³, ENSP00000257555⁴	EBI-634187,EBI-636034 I2D: score=2 STRING: ENSP00000257555
MAP2K3	P46734¹^,³, ENSP00000345083⁴	EBI-634187,EBI-602462 I2D: score=2 STRING: ENSP00000345083

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	11980910
GO:0007520	myoblast fusion	IEA	--
GO:0045893	positive regulation of transcription, DNA-templated	IDA	11980910

DYRK1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DYRK1B (DYR1B)

2 HMDB Compounds for DYRK1B About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

4 Novoseek inferred chemical compound relationships for DYRK1B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	57.4	7	17583556 (1), 19633423 (1), 16257974 (1)
serine	54.5	7	17583556 (1), 19633423 (1), 16257974 (1)
tyrosine	36.5	9	19633423 (2), 17583556 (1)
phosphatidylinositol	35.6	3	19852933 (1), 7528205 (1)

DYRK1B for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DYRK1B gene (3 alternative transcripts):

NM_004714.1 NM_006483.1 NM_006484.1

Unigene Cluster for DYRK1B:

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Hs.130988 [show with all ESTs]

Unigene Representative Sequence: Y17999

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000593685 ENST00000323039(uc002omj.3) ENST00000597639 ENST00000430012(uc002omk.3 uc002oml.3)

ENST00000601696 ENST00000600611 ENST00000601972 ENST00000348817(uc002omi.3)

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		hsa-miR-539 hsa-miR-1263 hsa-miR-148b hsa-miR-15a hsa-miR-765 hsa-miR-503 hsa-miR-3605-5p hsa-miR-511

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Additional mRNA sequence:

AF205861.1 AK074971.1 AK302127.1 BC009688.1 BC018751.1 BC025291.1 Y17999.1

6 DOTS entries:

DT.91763665 DT.100751337 DT.100751336 DT.101961855 DT.91736675 DT.100664884

Selected AceView cDNA sequences (see all 126):

CR620266 CR611407 BQ884039 BX115330 BC009688 BM726424 NM_004714 AI803954

BC025291 AF205861 CB216229 BU156847 NM_006483 BQ897084 BC018751 Y17999

CD622782 AL525248 AK074971 NM_006484 BM681591 AL530872 BI463860 BE390777

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DYRK1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGGAGTATG

About this image

DYRK1B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DYRK1B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.130988

UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463

Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon

or lung. Expressed in a variety of tumor cell lines

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK1B gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dyrk1b^{1 , 5}	dual-specificity tyrosine-(Y)-phosphorylation regulated more^{1, 5}	92.63(n)¹ 97.3(a)¹		7 (16.67 cM)⁵ 13549¹ NM_001271370.1¹ NP_001258299.1¹ 28179469⁵
lizard (Anolis carolinensis)	Reptilia	DYRK1B⁶	dual-specificity tyrosine-(Y)-phosphorylation regu...	65(a)	1 ↔ 1	GL343276.1(1707937-1720413)
tropical clawed frog (Xenopus tropicalis)	Amphibia	dyrk1a.2¹	dual-specificity tyrosine-(Y)-phosphorylation regulated more	70.15(n) 79.5(a)		100145447 NM_001126901.1 NP_001120373.1
zebrafish (Danio rerio)	Actinopterygii	psmb6²	Transcribed sequence with moderate similarity to protein more	83.66(n)		CK143492.1
fruit fly (Drosophila melanogaster)	Insecta	mnb³	circadian rhythm protein serine/threonine kinase	76(a)		--
worm (Caenorhabditis elegans)	Secernentea	mbk-1³	serine/threonine kinase (2 domains)	60(a)		X(14855249-14860148) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YAK1(YJL141C)⁴	Serine-threonine protein kinase; component of a glucose-sensing more	--		10(150390-147967) 853300 NP_012394.1

ENSEMBL Gene Tree for DYRK1B (if available)
TreeFam Gene Tree for DYRK1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DYRK1B gene

DYRK1A² DYRK2² DYRK3² HIPK1² ENSG00000272921² DYRK4² HIPK3² HIPK4²

HIPK2²

5 SIMAP similar genes for DYRK1B using alignment to 3 protein entries: DYR1B_HUMAN (see all proteins):

MNB/DYRK DYRK1A DYRK3 DYRK2 DYRK4

DYRK1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_040457⁴		A metastatic melanoma sample⁴	--	see VAR_040457	2	Q R	mis⁴		0	--	--	--	--
rs184042490^1,2		--	40315569(+)	`GTGGGA/GACAGA`	3	--	ds500¹		0	--	--	--	--
rs76965517^1,2	F	--	40315684(+)	`GCTAAG/CTCTGC`	3	--	ds500¹		2		NA EA	240
rs150691148^1,2		--	40315699(+)	`GCCCCA/GGCTTA`	3	--	ds500¹		0	--	--	--	--
rs187818902^1,2		--	40315755(+)	`CCTTTC/TAGGGT`	3	--	ds500¹		0	--	--	--	--
rs112957870^1,2	F	--	40315806(+)	`TCCACG/CATCTA`	3	--	ds500¹		3		CSA WA	122
rs12975231^1,2	C,F	--	40315835(+)	`CAGACC/ATGCAG`	3	--	ds500¹		5		NA EA	246
rs7254914^1,2	C,F,A	--	40315841(+)	`TGCAGC/ACTCAT`	3	--	ds500¹		13		NA WA CSA EA	375
rs74342061^1,2	C,F	--	40315949(+)	`GGGTCG/AGGTGA`	3	--	ds500¹		4		CSA WA NA	241
rs200681061^1,2	C	--	40316461(+)	`TCATCC/TGAGTC`	6	Q R	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DYRK1B (40315990 - 40324841 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for DYRK1B: About this table

Variant ID	Type	Subtype	PubMed ID
nsv911696	CNV	Loss	21882294
nsv9725	CNV	Gain+Loss	18304495
dgv1082e1	CNV	Complex	17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604556 OMIM disorders: --

9 diseases for DYRK1B:
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pancreatic ductal adenocarcinoma rhabdomyosarcoma down syndrome osteosarcoma

pancreatitis pancreatic cancer ovarian cancer lung cancer

adenocarcinoma

DYRK1B for disorders About GeneDecksing

3 Novoseek inferred disease relationships for DYRK1B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdomyosarcoma	52.7	10	16707437 (8), 19633423 (1)
tumors	10.5	12	19633423 (2), 12591926 (1), 10910078 (1), 16618736 (1) (see all 7)
cancer	0	7	17583556 (3), 16618736 (1)

Export disorders for DYRK1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DYRK1B gene, integrated from 10 sources (see all 48):
(articles sorted by number of sources associating them with DYRK1B)

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Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PubMed id 9918863)^{1, 2, 3, 9} Leder S.... Becker W. (Biochem. Biophys. Res. Commun. 1999)
Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PubMed id 10910078)^{1, 2, 9} Lee K.... Friedman E. (Cancer Res. 2000)
Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PubMed id 14593110)^{1, 2} Skurat A.V. and Dietrich A.D. (J. Biol. Chem. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (Nature 2004)
Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran- binding protein M. (PubMed id 14500717)^{1, 2} Zou Y.... Friedman E. (J. Biol. Chem. 2003)
Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)^{1, 2} Lim S.... Friedman E. (J. Biol. Chem. 2002)
The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. (PubMed id 12384504)^{1, 9} Lim S....Friedman E. (J. Biol. Chem. 2002)
The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (PubMed id 16618736)^{1, 9} Deng X....Friedman E. (Cancer Res. 2006)
The kinase Mirk is a potential therapeutic target in osteosarcoma. (PubMed id 20042639)^{1, 9} Yang C....Duan Z. (Carcinogenesis 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9149	HGNC: 3092	AceView: DYRK1B	Ensembl:ENSG00000105204	euGenes: HUgn9149
ECgene: DYRK1B	H-InvDB: DYRK1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DYRK1B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DYRK1B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DYRK1B gene
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Patent Information for DYRK1B gene:
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