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DYRK1B Gene

protein-coding   GIFtS: 61
GCID: GC19M040316

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...

  See DYRK1B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B1 2     Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B2
Minibrain-Related Kinase1 2 3     EC 2.7.12.13
MIRK2 3 5     EC 2.7.128
Mirk Protein Kinase2 3     

External Ids:    HGNC: 30921   Entrez Gene: 91492   Ensembl: ENSG000001052047   OMIM: 6045565   UniProtKB: Q9Y4633   

Export aliases for DYRK1B gene to outside databases

Previous GC identifers: GC19M040957 GC19M040707 GC19M044992 GC19M045007 GC19M036763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYRK1B Gene:
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal
and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear
functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced
exons within the catalytic domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for DYRK1B Gene:
DYRK1B (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B) is a protein-coding gene. Diseases associated with DYRK1B include abdominal obesity-metabolic syndrome 3. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463
Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances
the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon
carcinoma cell survival in mitogen-poor environments

Gene Wiki entry for DYRK1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYRK1B gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYRK1B promoter sequence
   Search Chromatin IP Primers for DYRK1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYRK1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

DYRK1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK1B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040316:  view genomic region     (about GC identifiers)

Start:
40,315,990 bp from pter      End:
40,324,841 bp from pter
Size:
8,852 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B  
Size: 629 amino acids; 69198 Da
Subunit: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9,
RAN, DYRK1B and COPS5. Interacts with DCAF7
Sequence caution: Sequence=AAC28914.1; Type=Erroneous gene model prediction;
Secondary accessions: O75258 O75788 O75789
Alternative splicing: 3 isoforms:  Q9Y463-1   Q9Y463-2   Q9Y463-3   

Explore the universe of human proteins at neXtProt for DYRK1B: NX_Q9Y463

Explore proteomics data for DYRK1B at MOPED

Post-translational modifications: 

  • Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required
    for dimerization1
  • Ubiquitination2 at Lys256
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DYRK1B (Q9Y463) (see all 9)
     QAPKARK  NPKRSAIKI  IGKGSFGQV  IVEVLGIPPA 


    See DYRK1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004705.1  NP_006474.1  NP_006475.1  

    ENSEMBL proteins: 
     ENSP00000469863   ENSP00000312789   ENSP00000472941   ENSP00000403182   ENSP00000471609  
     ENSP00000472861   ENSP00000221803  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
    Dyrk1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y463

    ProtoNet protein and cluster: Q9Y463

    UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with DYRK1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYR1B_HUMAN, Q9Y463
    Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances
    the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon
    carcinoma cell survival in mitogen-poor environments
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by RANBP9

         Genatlas biochemistry entry for DYRK1B:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse
    homolog,expressed in muscle and testis,involved in the regulation of nuclear functions

         Enzyme Numbers (IUBMB): EC 2.7.122 EC 2.7.12.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11980910
    GO:0004672protein kinase activity IDA11980910
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with DYRK1B           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DYRK1B:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  High actin ratio cells  Increased apoptosis 

         1 MGI phenotypic allele for Dyrk1b (no phenotypes)

    Find genes that share phenotypes with DYRK1B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYRK1B
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    hsa-mir-455-3p (MIRT037892), hsa-mir-30c-1-3p (MIRT038537), hsa-mir-320c (MIRT036171), hsa-mir-149-5p (MIRT045408), hsa-mir-320a (MIRT044780), hsa-mir-324-5p (MIRT043128), hsa-mir-335-5p (MIRT016969)

    Block miRNA regulation of human, mouse, rat DYRK1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DYRK1B (see all 28):
    hsa-miR-539 hsa-miR-1263 hsa-miR-148b hsa-miR-15a hsa-miR-765 hsa-miR-503 hsa-miR-3605-5p hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidDYRK1B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYR1B_HUMAN, Q9Y463: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with DYRK1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYRK1B About    
    See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    3Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with DYRK1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for DYRK1B
        Apoptosis and Autophagy
    Neuroscience
    Glucose / Energy Metabolism



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYRK1B
    Interactions:

        GeneGlobe Interaction Network for DYRK1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYRK1B (Q9Y4631, 2, 3 ENSP000003127894) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP9Q96S591, 3, ENSP000000116194EBI-634187,EBI-636085 I2D: score=5 STRING: ENSP00000011619
    HIPK2Q9H2X62, 3MINT-8085067 I2D: score=1 
    DCAF7P619621, 2, 3, ENSP000003083444EBI-634187,EBI-359808 MINT-8085204 MINT-8085121 I2D: score=4 STRING: ENSP00000308344
    HNF1AP208231, 3, ENSP000002575554EBI-634187,EBI-636034 I2D: score=2 STRING: ENSP00000257555
    MAP2K3P467341, 3, ENSP000003450834EBI-634187,EBI-602462 I2D: score=2 STRING: ENSP00000345083
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11980910
    GO:0007520myoblast fusion IEA--
    GO:0045893positive regulation of transcription, DNA-templated IDA11980910

    Find genes that share ontologies with DYRK1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYRK1B (DYR1B)

    2 HMDB Compounds for DYRK1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for DYRK1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 57.4 7 17583556 (1), 19633423 (1), 16257974 (1)
    serine 54.5 7 17583556 (1), 19633423 (1), 16257974 (1)
    tyrosine 36.5 9 19633423 (2), 17583556 (1)
    phosphatidylinositol 35.6 3 19852933 (1), 7528205 (1)



    Find genes that share compounds with DYRK1B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DYRK1B gene (3 alternative transcripts): 
    NM_004714.1  NM_006483.1  NM_006484.1  

    Unigene Cluster for DYRK1B:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
    Hs.130988  [show with all ESTs]
    Unigene Representative Sequence: Y17999
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593685 ENST00000323039(uc002omj.3) ENST00000597639 ENST00000430012(uc002omk.3 uc002oml.3)
    ENST00000601696 ENST00000600611 ENST00000601972 ENST00000348817(uc002omi.3)

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    Additional mRNA sequence: 

    AF205861.1 AK074971.1 AK302127.1 BC009688.1 BC018751.1 BC025291.1 Y17999.1 

    6 DOTS entries:

    DT.91763665  DT.100751337  DT.100751336  DT.101961855  DT.91736675  DT.100664884 

    Selected AceView cDNA sequences (see all 126):

    CR620266 CR611407 BQ884039 BX115330 BC009688 BM726424 NM_004714 AI803954 
    BC025291 AF205861 CB216229 BU156847 NM_006483 BQ897084 BC018751 Y17999 
    CD622782 AL525248 AK074971 NM_006484 BM681591 AL530872 BI463860 BE390777 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYRK1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAGTATG
    DYRK1B Expression
    About this image

    DYRK1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYRK1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130988

    UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463
    Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon
    or lung. Expressed in a variety of tumor cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DYRK1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dyrk1b1 , 5 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 92.63(n)1
    97.3(a)1
      7 (16.67 cM)5
    135491  NM_001271370.11  NP_001258299.11 
     281794695 
    lizard
    (Anolis carolinensis)
    Reptilia DYRK1B6
    dual-specificity tyrosine-(Y)-phosphorylation regu...
    65(a)
    1 ↔ 1
    GL343276.1(1707937-1720413)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dyrk1a.21 dual-specificity tyrosine-(Y)-phosphorylation regulated more 70.15(n)
    79.5(a)
      100145447  NM_001126901.1  NP_001120373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii psmb62 Transcribed sequence with moderate similarity to protein more 83.66(n)    CK143492.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mnb3 circadian rhythm protein
    serine/threonine kinase
    76(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mbk-13 serine/threonine kinase (2 domains) 60(a)   X(14855249-14860148)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAK1(YJL141C)4 Serine-threonine protein kinase; component of a glucose-sensing more   --   10(150390-147967) 853300  NP_012394.1 


    ENSEMBL Gene Tree for DYRK1B (if available)
    TreeFam Gene Tree for DYRK1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYRK1B gene
    DYRK1A2  DYRK22  DYRK32  HIPK12  ENSG000002729212  DYRK42  HIPK32  HIPK42  
    HIPK22  
    5 SIMAP similar genes for DYRK1B using alignment to 3 protein entries:     DYR1B_HUMAN (see all proteins):
    MNB/DYRK    DYRK1A    DYRK3    DYRK2    DYRK4

    Find genes that share paralogs with DYRK1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYRK1B (see all 248)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0404574
    A metastatic melanoma sample4--see VAR_0404572 Q R mis40--------
    rs1840424901,2
    --40315569(+) GTGGGA/GACAGA 3 -- ds50010--------
    rs769655171,2
    F--40315684(+) GCTAAG/CTCTGC 3 -- ds50012Minor allele frequency- C:0.02NA EA 240
    rs1506911481,2
    --40315699(+) GCCCCA/GGCTTA 3 -- ds50010--------
    rs1878189021,2
    --40315755(+) CCTTTC/TAGGGT 3 -- ds50010--------
    rs1129578701,2
    F--40315806(+) TCCACG/CATCTA 3 -- ds50013Minor allele frequency- C:0.06CSA WA 122
    rs129752311,2
    C,F--40315835(+) CAGACC/ATGCAG 3 -- ds50015Minor allele frequency- A:0.10NA EA 246
    rs72549141,2
    C,F,A--40315841(+) TGCAGC/ACTCAT 3 -- ds500113Minor allele frequency- A:0.50NA WA CSA EA 375
    rs743420611,2
    C,F--40315949(+) GGGTCG/AGGTGA 3 -- ds50014Minor allele frequency- A:0.08CSA WA NA 241
    rs2006810611,2
    C--40316461(+) TCATCC/TGAGTC 6 Q R mis10--------

    HapMap Linkage Disequilibrium report for DYRK1B (40315990 - 40324841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DYRK1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911696CNV Loss21882294
    nsv9725CNV Gain+Loss18304495
    dgv1082e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604556    OMIM disorders: --

    1 disease for DYRK1B:    
    About MalaCards
    abdominal obesity-metabolic syndrome 3


    Find genes that share disorders with DYRK1B           About GenesLikeMe

    3 Novoseek inferred disease relationships for DYRK1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 52.7 10 16707437 (8), 19633423 (1)
    tumors 10.5 12 19633423 (2), 12591926 (1), 10910078 (1), 16618736 (1) (see all 7)
    cancer 0 7 17583556 (3), 16618736 (1)


    Export disorders for DYRK1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYRK1B gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with DYRK1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PubMed id 9918863)1, 2, 3, 9 Leder S.... Becker W. (Biochem. Biophys. Res. Commun. 1999)
    2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PubMed id 10910078)1, 2, 9 Lee K.... Friedman E. (Cancer Res. 2000)
    3. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PubMed id 14593110)1, 2 Skurat A.V. and Dietrich A.D. (J. Biol. Chem. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran- binding protein M. (PubMed id 14500717)1, 2 Zou Y.... Friedman E. (J. Biol. Chem. 2003)
    7. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)1, 2 Lim S.... Friedman E. (J. Biol. Chem. 2002)
    8. The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. (PubMed id 12384504)1, 9 Lim S....Friedman E. (J. Biol. Chem. 2002)
    9. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (PubMed id 16618736)1, 9 Deng X....Friedman E. (Cancer Res. 2006)
    10. The kinase Mirk is a potential therapeutic target in osteosarcoma. (PubMed id 20042639)1, 9 Yang C....Duan Z. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9149 HGNC: 3092 AceView: DYRK1B Ensembl:ENSG00000105204 euGenes: HUgn9149
    ECgene: DYRK1B H-InvDB: DYRK1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYRK1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DYRK1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYRK1B gene:
    Search GeneIP for patents involving DYRK1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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