DYRK1B Gene
protein-coding GIFtS: 59
GCID: GC19M040316
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dual-specificity tyrosine-(Y)-phosphorylation regulated...
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Aliases
for DYRK1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B1 2 | | Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B2 | | MIRK1 2 3 5 | | EC 2.7.12.13 | | Minibrain-Related Kinase2 3 | | EC 2.7.128 | | Mirk Protein Kinase2 3 | | |
Export aliases for DYRK1B gene to outside databasesPrevious GC identifers: GC19M040957 GC19M040707 GC19M044992 GC19M045007 GC19M036763 |
Summaries
for DYRK1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DYRK1B:
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal andis found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions.Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within thecatalytic domain. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances thetranscriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cellsurvival in mitogen-poor environments
Gene Wiki entry for DYRK1B
|
Genomic Views
for DYRK1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYRK1B gene promoter:
MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYRK1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYRK1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2DYRK1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M040316: view genomic region
(about GC identifiers)
Start:
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40,315,990 bp from pter |
End:
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40,324,841 bp from pter |
Size:
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8,852 bases |
Orientation:
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minus strand |
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Proteins
for DYRK1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463 (See
protein sequence)Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B Size: 629 amino acids; 69198 Da
Subunit: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN,DYRK1B and COPS5. Interacts with DCAF7
Subcellular location: Nucleus
Sequence caution: Sequence=AAC28914.1; Type=Erroneous gene model prediction;
Secondary accessions: O75258 O75788 O75789Alternative splicing: 3 isoforms: Q9Y463-1 Q9Y463-2 Q9Y463-3 Explore the universe of human proteins at neXtProt for DYRK1B: NX_Q9Y463
Post-translational modifications:
Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required fordimerization1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y463
4/9 DME Specific Peptides for DYRK1B (Q9Y463) (see all 9)
DYRK1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_004705.1 NP_006474.1 NP_006475.1
ENSEMBL proteins: ENSP00000312789 ENSP00000221803 ENSP00000403182
Human Recombinant Protein Products for DYRK1B:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DYRK1B for ontologies About GeneDecksing
DYRK1B Antibody Products:
Assay Products for DYRK1B: |
Protein
Domains /
Families
for DYRK1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYRK1B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y463ProtoNet protein and cluster: Q9Y463 UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamilySimilarity: Contains 1 protein kinase domain |
Function
for DYRK1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DYR1B_HUMAN, Q9Y463Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances thetranscriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cellsurvival in mitogen-poor environmentsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by RANBP9 Genatlas biochemistry entry for DYRK1B:dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mousehomolog,expressed in muscle and testis,involved in the regulation of nuclear functions
Enzyme Numbers (IUBMB): EC 2.7.122 EC 2.7.12.11
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
DYRK1B for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for DYRK1B:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYRK1B (see all 5)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B |
|
Pathways & Interactions
for DYRK1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Neuroscience | | | 2 | Apoptosis and Autophagy | | | 3 | Glucose / Energy Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Cell Signaling Technology (CST) Pathways for DYRK1B
DYRK1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DYRK1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/17 Interacting proteins for DYRK1B (Q9Y4631, 2, 3 ENSP000003127894) via UniProtKB, MINT, STRING, and/or I2D (see all 17)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RANBP9 | Q96S591, 3, ENSP000000116194 | EBI-634187,EBI-636085 I2D:
score=5 STRING: ENSP00000011619 | | HIPK2 | Q9H2X62, 3 | MINT-8085067 I2D:
score=1 | | DCAF7 | P619622, 3, ENSP000003083444 | MINT-8085204 MINT-8085121 I2D:
score=4 STRING: ENSP00000308344 | | HNF1A | P208231, 3, ENSP000002575554 | EBI-634187,EBI-636034 I2D:
score=2 STRING: ENSP00000257555 | | MAP2K3 | P467341, 3, ENSP000003450834 | EBI-634187,EBI-602462 I2D:
score=2 STRING: ENSP00000345083 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
DYRK1B for ontologies About GeneDecksing
|
Drugs & Compounds
for DYRK1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DYRK1B for compounds About GeneDecksing
 Browse Tocris compounds for DYRK1B
2 HMDB Compounds for DYRK1B About this table
4 Novoseek chemical compound relationships for DYRK1B gene About this table
Search CenterWatch for drugs/clinical trials and news about DYRK1B / DYR1B
|
Transcripts
for DYRK1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DYRK1B gene (3 alternative transcripts): NM_004714.1 NM_006483.1 NM_006484.1 Unigene Cluster for DYRK1B: Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Hs.130988 [show with all ESTs]Unigene Representative Sequence: Y179993 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000323039(uc002omj.3) ENST00000348817(uc002omi.3) ENST00000430012(uc002omk.3 uc002oml.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYRK1B (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYRK1B (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DYRK1B (NM_006483) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYRK1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1B |
Additional cDNA sequence: AF205861.1 AK074971.1 AK302127.1 BC009688.1 BC018751.1 BC025291.1 Y17999.1 6 DOTS entries: DT.91763665 DT.100751337 DT.100751336 DT.101961855 DT.91736675 DT.100664884 24/126 AceView cDNA sequences (see all 126): BQ897084 AK074971 CD622782 BX115330 CB216229 AL530872 BU156847 BC009688 NM_006484 BQ884039 Y17999 NM_006483 BC018751 CR620266 BC025291 BM681591 CR611407 AF205861 AL525248 AI803954 NM_004714 BM726424 CD622783 BI827908
GeneLoc Exon Structure
|
Expression
for DYRK1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DYRK1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGAGTATG
About this image
See DYRK1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYRK1B
SOURCE GeneReport for Unigene cluster: Hs.130988
UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon orlung. Expressed in a variety of tumor cell lines
SABiosciences Custom PCR Arrays for DYRK1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYRK1B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B |
Orthologs
for DYRK1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DYRK1B gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for DYRK1B (if available)
TreeFam Gene Tree for DYRK1B (if available) |
Paralogs
for DYRK1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DYRK1B gene
- DYRK32 DYRK22 DYRK1A2 HIPK12 DYRK42 HIPK32 HIPK42 HIPK22
4 SIMAP similar genes for DYRK1B using alignment to 3 protein entries: DYR1B_HUMAN (see all proteins):DYRK1A DYRK3 DYRK2 DYRK4
DYRK1B for paralogs About GeneDecksing
|
Genomic Variants
for DYRK1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DYRK1B (40315990 - 40324841 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DYRK1B
2 CNVs: 30906 4079 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYRK1B |
|
Disorders
/ Diseases
for DYRK1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYRK1B for disorders About GeneDecksing
OMIM gene information: 604556
OMIM disorders: --
11  diseases for DYRK1B: About MalaCardspancreatic ductal adenocarcinoma down syndrome colon carcinoma pancreatitis
colon cancer pancreatic cancer osteosarcoma lung cancer
adenocarcinoma carcinoma malaria
3 Novoseek disease relationships for DYRK1B gene About this table
Export disorders for DYRK1B gene to outside databases
|
Publications
for DYRK1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DYRK1B gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with DYRK1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PubMed id 9918863)1, 2, 3, 9 Leder S.... Becker W. (1999)
- Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PubMed id 10910078)1, 2, 9 Lee K.... Friedman E. (2000)
- Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PubMed id 14593110)1, 2 Skurat A.V. and Dietrich A.D. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran- binding protein M. (PubMed id 14500717)1, 2 Zou Y.... Friedman E. (2003)
- Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)1, 2 Lim S....Friedman E. (2002)
- The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. (PubMed id 12384504)1, 9 Lim S....Friedman E. (2002)
- The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (PubMed id 16618736)1, 9 Deng X....Friedman E. (2006)
- The kinase Mirk is a potential therapeutic target in osteosarcoma. (PubMed id 20042639)1, 9 Yang C....Duan Z. (2010)
|
External Searches for DYRK1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYRK1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYRK1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYRK1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DYRK1B gene:
Search GeneIP for patents involving DYRK1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYRK1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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