Aliases for DYRK1B Gene
Aliases for DYRK1B Gene
External Ids for DYRK1B Gene
- HGNC: 3092
- Entrez Gene: 9149
- Ensembl: ENSG00000105204
- OMIM: 604556
- UniProtKB: Q9Y463
Previous GeneCards Identifiers for DYRK1B Gene
- GC19M040957
- GC19M040707
- GC19M044992
- GC19M045007
- GC19M040316
- GC19M036763
Summaries for DYRK1B Gene
-
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for DYRK1B Gene
DYRK1B (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include Abdominal Obesity-Metabolic Syndrome 3 and Chronic Cervicitis. Among its related pathways are Glucose / Energy Metabolism and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK1A.
UniProtKB/Swiss-Prot for DYRK1B Gene
-
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
-
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.
Additional gene information for DYRK1B Gene
- Monarch Initiative
- Search for DYRK1B at DataMed
- Search for DYRK1B at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK1B Gene
Genomics for DYRK1B Gene
GeneHancer (GH) Regulatory Elements for DYRK1B Gene
Promoters and enhancers for DYRK1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DYRK1B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DYRK1B gene promoter:
Regulatory Element Products
Genomic Locations for DYRK1B Gene
Genomic Locations for DYRK1B Gene
- chr19:39,825,347-39,834,233
- (GRCh38/hg38)
- Size:
- 8,887 bases
- Orientation:
- Minus strand
- chr19:40,315,990-40,324,841
- (GRCh37/hg19)
Genomic View for DYRK1B Gene
Genes around DYRK1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
DYRK1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DYRK1B Gene
Proteins for DYRK1B Gene
-
Protein details for DYRK1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y463-DYR1B_HUMAN
- Recommended name:
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B
- Protein Accession:
- Q9Y463
- O75258
- O75788
- O75789
Protein attributes for DYRK1B Gene
- Size:
- 629 amino acids
- Molecular mass:
- 69198 Da
- Quaternary structure:
-
- Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
- SequenceCaution:
-
- Sequence=AAC28914.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for DYRK1B Gene
Selected DME Specific Peptides for DYRK1B Gene
- Q9Y463:
-
- HDTEMKYYIVHLK
- YDLAIDMWSLGCILVEMHTGEPLFSG
- FRGVSLNLTRK
- IVEVLGIPPA
- LSYNLYDLLRNT
- IGKGSFGQV
- DLIKTYKHIN
- NPKRSAIKI
- QAPKARK
Post-translational modifications for DYRK1B Gene
- Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
Other Protein References for DYRK1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for DYRK1B (DYRK1B)
-
Custom Antibody ServicesOriGene Antibodies for DYRK1B
- Novus Biologicals Antibodies for DYRK1B
-
Abcam antibodies for DYRK1B
- Invitrogen Antibodies for DYRK1B
- GeneTex DYRK1B antibody for DYRK1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for DYRK1B
Protein Products
-
OriGene Purified Proteins for DYRK1B
- Search Origene for MassSpec and Protein Over-expression Lysates for DYRK1B
- Origene Custom Protein Services for DYRK1B
- antibodies-online: Search results for 7 available DYRK1B Proteins ranked by validation data
- Compare Top DYRK1B Proteins
-
Quality Products:
- Search GeneTex for Proteins for DYRK1B
-
Abcam proteins for DYRK1B
Assay Products
Domains & Families for DYRK1B Gene
Gene Families for DYRK1B Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for DYRK1B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DYRK1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y463UniProtKB/Swiss-Prot:
DYR1B_HUMAN :- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Function for DYRK1B Gene
Molecular function for DYRK1B Gene
- GENATLAS Biochemistry:
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse homolog,expressed in muscle and testis,involved in the regulation of nuclear functions
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by RANBP9.
- UniProtKB/Swiss-Prot Function:
- Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
Enzyme Numbers (IUBMB) for DYRK1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IDA | 11980910 |
| GO:0004672 | protein kinase activity | IDA,TAS | 11980910 |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
Phenotypes for DYRK1B Gene
- MGI mutant phenotypes for DYRK1B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DYRK1B:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Lamellipodia cells
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased viability
- Apoptosis resistance
Animal Models for DYRK1B Gene
- MGI Knock Outs for DYRK1B:
-
- Dyrk1b tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DYRK1B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK1B gene
- Search ViGene Biosciences for DYRK1B
CRISPR Products
-
OriGene CRISPR knockouts for DYRK1B
- genomics-online: gRNA clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
- Applied Biological Materials CRISPR for DYRK1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK1B
- GenScript: Design CRISPR guide RNA sequences for DYRK1B
miRNA for DYRK1B Gene
- miRTarBase miRNAs that target DYRK1B
-
- hsa-mir-335-5p (MIRT016969)
- hsa-mir-320c (MIRT036171)
- hsa-mir-455-3p (MIRT037892)
- hsa-mir-30c-1-3p (MIRT038537)
- hsa-mir-324-5p (MIRT043128)
- hsa-mir-320a (MIRT044780)
- hsa-mir-149-5p (MIRT045408)
- hsa-mir-6763-5p (MIRT497031)
- hsa-mir-3150a-3p (MIRT497032)
- hsa-mir-4460 (MIRT497033)
- hsa-mir-4727-3p (MIRT497034)
- hsa-mir-6825-5p (MIRT497035)
- hsa-mir-939-5p (MIRT497036)
- hsa-mir-1343-5p (MIRT497037)
- hsa-mir-3175 (MIRT497038)
- hsa-mir-6883-5p (MIRT497039)
- hsa-mir-6785-5p (MIRT497040)
- hsa-mir-4728-5p (MIRT497041)
- hsa-mir-149-3p (MIRT497042)
- hsa-mir-6090 (MIRT497043)
- hsa-mir-3926 (MIRT497044)
- hsa-mir-6797-5p (MIRT497045)
- hsa-mir-1249-5p (MIRT497046)
- hsa-mir-6133 (MIRT497047)
- hsa-mir-6130 (MIRT497048)
- hsa-mir-6129 (MIRT497049)
- hsa-mir-6127 (MIRT497050)
- hsa-mir-4510 (MIRT497051)
- hsa-mir-4419a (MIRT497052)
- hsa-mir-1296-3p (MIRT497053)
- hsa-mir-548as-3p (MIRT497054)
- hsa-mir-491-5p (MIRT497055)
- hsa-mir-9-5p (MIRT734754)
miRNA Products
- Search ViGene Biosciences for DYRK1B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DYRK1B
- Browse OriGene Inhibitory RNA Products For DYRK1B
- genomics-online: shRNA clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK1B gene
Clone Products
-
OriGene ORF clones in human for DYRK1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DYRK1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DYRK1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYRK1B
- genomics-online: cdna clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
- orf clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
- Applied Biological Materials Clones for DYRK1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DYRK1B
-
ViGene Biosciences adenoviral particle packaged cDNA for DYRK1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DYRK1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK1B gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for DYRK1B Gene
Localization for DYRK1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for DYRK1B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | -- |
Pathways & Interactions for DYRK1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis and Autophagy | ||
| 2 | Glucose / Energy Metabolism | ||
| 3 | Neuroscience | ||
Pathways by source for DYRK1B Gene
3 Cell Signaling Technology pathways for DYRK1B Gene
Interacting Proteins for DYRK1B Gene
Selected Interacting proteins:
ENSP00000312789
Q9Y463-DYR1B_HUMAN
for DYRK1B Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for DYRK1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA | 11980910 |
| GO:0007520 | myoblast fusion | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA | 11980910 |
Drugs & Compounds for DYRK1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| ATP | Investigational | Nutra | Agonist | 0 | ||
| AZ191 | Pharma | DYRK1B inhibitor,potent and selective | 0 | |||
| ID-8 | Pharma | 0 | ||||
| Harmine | Pharma | Potent and selective DYRK1A inhibitor | 1 | |||
| INDY | Pharma | Dyrk1A and Dyrk1B inhibitor, selective, DYRK1A/B inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(3) Tocris Compounds for DYRK1B Gene
(2) ApexBio Compounds for DYRK1B Gene
Transcripts for DYRK1B Gene
mRNA/cDNA for DYRK1B Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (126) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DYRK1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for DYRK1B
- genomics-online: gRNA clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
- Applied Biological Materials CRISPR for DYRK1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DYRK1B
- GenScript: Design CRISPR guide RNA sequences for DYRK1B
miRNA Products
- Search ViGene Biosciences for DYRK1B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DYRK1B
- Browse OriGene Inhibitory RNA Products For DYRK1B
- genomics-online: shRNA clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
-
ViGene Biosciences ready-to-package AAV shRNAs for DYRK1B gene
Clone Products
-
OriGene ORF clones in human for DYRK1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DYRK1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DYRK1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYRK1B
- genomics-online: cdna clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
- orf clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
- Applied Biological Materials Clones for DYRK1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DYRK1B Gene
mRNA differential expression in normal tissues according to GTEx for DYRK1B Gene
This gene is overexpressed in Muscle - Skeletal (x6.6) and Testis (x5.6).
This gene is overexpressed in Blymphocyte (65.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYRK1B Gene
NURSA nuclear receptor signaling pathways regulating expression of DYRK1B Gene:
DYRK1BSOURCE GeneReport for Unigene cluster for DYRK1B Gene:
Hs.130988mRNA Expression by UniProt/SwissProt for DYRK1B Gene:
Q9Y463-DYR1B_HUMAN
Tissue specificity:
Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
Evidence on tissue expression from TISSUES for DYRK1B Gene
- Muscle(4.6)
- Pancreas(4.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK1B Gene
Germ Layers:
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
Organs:
Head and neck:
- ear
Thorax:
- heart
Abdomen:
- duodenum
- intestine
- liver
- small intestine
General:
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for DYRK1B
-
OriGene qPCR primer pairs and template standards for DYRK1B
- genomics-online: primer clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
-
Recommended
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DYRK1B Gene
Orthologs for DYRK1B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DYRK1B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DYRK1B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DYRK1B 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Dyrk1b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dyrk1b 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DYRK1B 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DYRK1B 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DYRK1B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dyrk1a.2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dyrk1b 33 34 |
|
||
| psmb6 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mnb 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mbk-1 35 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YAK1 34 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1202 34 |
|
OneToMany |
- Species where no ortholog for DYRK1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DYRK1B Gene
Variants for DYRK1B Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs367643250 | pathogenic, Abdominal obesity-metabolic syndrome 3, Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812] | 39,830,443(-) | G/A | coding_sequence_variant, missense_variant | |
| rs556237495 | benign, Abnormality of neuronal migration | 39,828,479(-) | C/A/T | coding_sequence_variant, missense_variant | |
| rs587777380 | pathogenic, Abdominal obesity-metabolic syndrome 3, Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812] | 39,830,478(-) | T/G | coding_sequence_variant, missense_variant | |
| VAR_040457 | A metastatic melanoma sample | p.Gln275Arg | |||
| rs78838108 | likely-benign, not specified | 39,827,594(-) | G/A | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758760 | CNV | gain | 17122850 |
| nsv9725 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.83;
34.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DYRK1B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK1B Gene
Disorders for DYRK1B Gene
(2) MalaCards diseases for DYRK1B Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| abdominal obesity-metabolic syndrome 3 |
|
|
| chronic cervicitis |
|
|
Search DYRK1B in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DYR1B_HUMAN- Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269 PubMed:24827035}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for DYRK1B
No data available for Genatlas for DYRK1B Gene
Publications for DYRK1B Gene
- Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PMID: 9918863) Leder S … Becker W (Biochemical and biophysical research communications 1999) 2 3 4 22 58
- Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PMID: 10910078) Lee K … Friedman E (Cancer research 2000) 3 4 22 58
- A form of the metabolic syndrome associated with mutations in DYRK1B. (PMID: 24827035) Keramati AR … Mani A (The New England journal of medicine 2014) 3 4 58
- The kinase Mirk is a potential therapeutic target in osteosarcoma. (PMID: 20042639) Yang C … Duan Z (Carcinogenesis 2010) 3 22 58
- Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. (PMID: 19633423) Gao J … Haura EB (Cancer biology & therapy 2009) 3 22 58
Products for DYRK1B Gene
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- Custom Antibody ServicesOriGene Antibodies for DYRK1B
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- Invitrogen Antibodies for DYRK1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- Cyagen custom Knockout/knockin (KOKI) mouse models for DYRK1B
- VectorBuilder custom plasmid, inducible vectors for DYRK1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYRK1B
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for DYRK1B
- antibodies-online: Search results for 108 available DYRK1B Antibodies ranked by validation data
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- antibodies-online: Search results for available DYRK1B related products ranked by validation data
- antibodies-online: Search results for 7 available DYRK1B Proteins ranked by validation data
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- Quality Products:
- GeneTex DYRK1B antibody for DYRK1B
- Search GeneTex for Proteins for DYRK1B
- ViGene Biosciences adenoviral particle packaged cDNA for DYRK1B gene
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- ViGene Biosciences ready-to-package AAV shRNAs for DYRK1B gene
- Search ViGene Biosciences for DYRK1B
- Santa Cruz Biotechnology (SCBT) Antibodies for DYRK1B
- Search Santa Cruz Biotechnology (SCBT) for DYRK1B siRNA/shRNA
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- Horizon Cell Lines for DYRK1B
- genomics-online: cdna clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
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- genomics-online: shRNA clones - Search results for 124 available DYRK1B gene related products
- Overview of 124 available DYRK1B gene related products
- Recommended
Sources for DYRK1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (135) Horizon
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- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew