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DYRK1B Gene(Protein Coding)

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B

GCID:
GC19M039825
GIFtS:
63
Genes Participants
UDN Logo

Aliases for DYRK1B Gene

Aliases for DYRK1B Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B 2 3
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2 3 5
  • Minibrain-Related Kinase 2 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2 3
  • Mirk Protein Kinase 3 4
  • MIRK 3 4
  • EC 2.7.12.1 4
  • EC 2.7.12 63
  • AOMS3 3

External Ids for DYRK1B Gene

Previous GeneCards Identifiers for DYRK1B Gene

  • GC19M040957
  • GC19M040707
  • GC19M044992
  • GC19M045007
  • GC19M040316
  • GC19M036763

Summaries for DYRK1B Gene

Entrez Gene Summary for DYRK1B Gene

  • This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DYRK1B Gene

DYRK1B (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include Abdominal Obesity-Metabolic Syndrome 3 and Chronic Cervicitis. Among its related pathways are Glucose / Energy Metabolism and Apoptosis and Autophagy. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is HIPK4.

UniProtKB/Swiss-Prot for DYRK1B Gene

  • Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Tocris Summary for DYRK1B Gene

  • Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.

Gene Wiki entry for DYRK1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK1B Gene

Genomics for DYRK1B Gene

Products:

  1. Regulatory Element

Regulatory Elements for DYRK1B Gene

Enhancers for DYRK1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DYRK1B on UCSC Golden Path with GeneCards custom track

Promoters for DYRK1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DYRK1B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DYRK1B gene promoter:

Genomic Location for DYRK1B Gene

Chromosome:
19
Start:
39,825,347 bp from pter
End:
39,834,233 bp from pter
Size:
8,887 bases
Orientation:
Minus strand

Genomic View for DYRK1B Gene

Genes around DYRK1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DYRK1B Gene

Proteins for DYRK1B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DYRK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y463-DYR1B_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Protein Accession:
    Q9Y463
    Secondary Accessions:
    • O75258
    • O75788
    • O75789

    Protein attributes for DYRK1B Gene

    Size:
    629 amino acids
    Molecular mass:
    69198 Da
    Quaternary structure:
    • Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
    SequenceCaution:
    • Sequence=AAC28914.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK1B Gene

Proteomics data for DYRK1B Gene at MOPED

Protein Expression for DYRK1B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DYRK1B Gene

Q9Y463:

Post-translational modifications for DYRK1B Gene

  • Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYRK1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DYRK1B (DYRK1B)

Domains & Families for DYRK1B Gene

Gene Families for DYRK1B Gene

IUPHAR :

Protein Domains for DYRK1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DYRK1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y463

UniProtKB/Swiss-Prot:

DYR1B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK1B: view

Function for DYRK1B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DYRK1B Gene

GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse homolog,expressed in muscle and testis,involved in the regulation of nuclear functions
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by RANBP9.
UniProtKB/Swiss-Prot Function:
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Enzyme Numbers (IUBMB) for DYRK1B Gene

Gene Ontology (GO) - Molecular Function for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11980910
GO:0004672 protein kinase activity IEA,IDA 11980910
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK1B: view

Phenotypes for DYRK1B Gene

GenomeRNAi human phenotypes for DYRK1B:
genes like me logo Genes that share phenotypes with DYRK1B: view

Human Phenotype Ontology for DYRK1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK1B

miRNA for DYRK1B Gene

miRTarBase miRNAs that target DYRK1B

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DYRK1B Gene

Localization for DYRK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK1B Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYRK1B Gene COMPARTMENTS Subcellular localization image for DYRK1B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DYRK1B Gene

Pathways & Interactions for DYRK1B Gene

genes like me logo Genes that share pathways with DYRK1B: view

Pathways by source for DYRK1B Gene

3 Cell Signaling Technology pathways for DYRK1B Gene

SIGNOR curated interactions for DYRK1B Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 11980910
GO:0045893 positive regulation of transcription, DNA-templated IDA 11980910
genes like me logo Genes that share ontologies with DYRK1B: view

Drugs & Compounds for DYRK1B Gene

Products:

  1. Drug

(6) Drugs for DYRK1B Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Harmine Experimental Pharma Potent and selective DYRK1A inhibitor 0
ID-8 Pharma 0

(6) Additional Compounds for DYRK1B Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
INDY
1169755-45-6
ProINDY
719277-30-2
TC-S 7004
1386979-55-0
TG 003
719277-26-6

(5) Tocris Compounds for DYRK1B Gene

Compound Action Cas Number
Harmine Potent and selective DYRK1A inhibitor 442-51-3
INDY DYRK1A/B inhibitor 1169755-45-6
ProINDY DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997) 719277-30-2
TC-S 7004 Potent and selective DYRK1A/B inhibitor 1386979-55-0
TG 003 Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B 719277-26-6

(1) ApexBio Compounds for DYRK1B Gene

Compound Action Cas Number
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK1B: view

Transcripts for DYRK1B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DYRK1B Gene

(11) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DYRK1B Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1B Gene

No ASD Table

Relevant External Links for DYRK1B Gene

GeneLoc Exon Structure for
DYRK1B
ECgene alternative splicing isoforms for
DYRK1B

Expression for DYRK1B Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DYRK1B Gene

mRNA expression in normal human tissues for DYRK1B Gene
mRNA expression by BioGPS for DYRK1B GenemRNA expression by GTEx for DYRK1B Gene

mRNA differential expression in normal tissues according to GTEx for DYRK1B Gene

This gene is overexpressed in Muscle - Skeletal (x6.6) and Testis (x5.6).

Protein differential expression in normal tissues from HIPED for DYRK1B Gene

This gene is overexpressed in Blymphocyte (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYRK1B Gene



SOURCE GeneReport for Unigene cluster for DYRK1B Gene Hs.130988

mRNA Expression by UniProt/SwissProt for DYRK1B Gene

Q9Y463-DYR1B_HUMAN
Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
genes like me logo Genes that share expression patterns with DYRK1B: view

Protein tissue co-expression partners for DYRK1B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DYRK1B Gene

Orthologs for DYRK1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DYRK1B 35
  • 94.01 (n)
  • 98.73 (a)
DYRK1B 36
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DYRK1B 35
  • 95.5 (n)
  • 98.89 (a)
DYRK1B 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dyrk1b 35
  • 92.63 (n)
  • 97.3 (a)
Dyrk1b 16
Dyrk1b 36
  • 97 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia DYRK1B 35
  • 99.74 (n)
  • 100 (a)
DYRK1B 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dyrk1b 35
  • 92.76 (n)
  • 97.45 (a)
oppossum
(Monodelphis domestica)
 Mammalia DYRK1B 36
  • 79 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DYRK1B 36
  • 70 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DYRK1B 36
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dyrk1a.2 35
  • 70.15 (n)
  • 79.5 (a)
zebrafish
(Danio rerio)
 Actinopterygii dyrk1b 35
  • 73.95 (n)
  • 76.65 (a)
psmb6 35
dyrk1b 36
  • 56 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta mnb 37
  • 76 (a)
mnb 36
  • 36 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea mbk-1 37
  • 60 (a)
mbk-1 36
  • 32 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes YAK1 36
  • 19 (a)
 OneToMany
YAK1 38
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.1202 36
  • 73 (a)
 OneToMany
Species with no ortholog for DYRK1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK1B Gene

ENSEMBL:
Gene Tree for DYRK1B (if available)
TreeFam:
Gene Tree for DYRK1B (if available)

Paralogs for DYRK1B Gene

Paralogs for DYRK1B Gene

(5) SIMAP similar genes for DYRK1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DYRK1B: view

Variants for DYRK1B Gene

Sequence variations from dbSNP and Humsavar for DYRK1B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040454 -
VAR_040455 -
rs35858874 - 39,828,404(+) GATGC(C/T)GAGCT reference, missense
VAR_040457 A metastatic melanoma sample
VAR_071773 Abdominal obesity-metabolic syndrome 3 (AOMS3)

Structural Variations from Database of Genomic Variants (DGV) for DYRK1B Gene

Variant ID Type Subtype PubMed ID
dgv1082e1 CNV Complex 17122850
nsv911696 CNV Loss 21882294
nsv9725 CNV Gain+Loss 18304495

Variation tolerance for DYRK1B Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYRK1B Gene

Human Gene Mutation Database (HGMD)
DYRK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK1B Gene

Disorders for DYRK1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for DYRK1B Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
abdominal obesity-metabolic syndrome 3
  • central obesity, type 2 diabetes, hypertension, and early-onset coronary artery disease
chronic cervicitis
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DYR1B_HUMAN
  • Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269 PubMed:24827035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DYRK1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYRK1B
genes like me logo Genes that share disorders with DYRK1B: view

No data available for Genatlas for DYRK1B Gene

Publications for DYRK1B Gene

  1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PMID: 9918863) Leder S. … Becker W. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. The kinase Mirk is a potential therapeutic target in osteosarcoma. (PMID: 20042639) Yang C. … Duan Z. (Carcinogenesis 2010) 3 23
  3. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. (PMID: 19633423) Gao J. … Haura E.B. (Cancer Biol. Ther. 2009) 3 23
  4. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (PMID: 16618736) Deng X. … Friedman E. (Cancer Res. 2006) 3 23
  5. The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling. (PMID: 16257974) Jin K. … Friedman E. (J. Biol. Chem. 2005) 3 23

Products for DYRK1B Gene

Sources for DYRK1B Gene

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