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Aliases for DYRK1B Gene

Aliases for DYRK1B Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B 2 3 5
  • Minibrain-Related Kinase 2 3 4
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2 3
  • Mirk Protein Kinase 3 4
  • MIRK 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B 3
  • EC 2.7.12.1 4
  • EC 2.7.12 56
  • AOMS3 3

External Ids for DYRK1B Gene

Previous GeneCards Identifiers for DYRK1B Gene

  • GC19M040957
  • GC19M040707
  • GC19M044992
  • GC19M045007
  • GC19M040316
  • GC19M036763

Summaries for DYRK1B Gene

Entrez Gene Summary for DYRK1B Gene

  • This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DYRK1B Gene

DYRK1B (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include Abdominal Obesity-Metabolic Syndrome 3 and Chronic Cervicitis. Among its related pathways are Glucose / Energy Metabolism and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot for DYRK1B Gene

  • Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Tocris Summary for DYRK1B Gene

  • Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.

Gene Wiki entry for DYRK1B Gene

Additional gene information for DYRK1B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK1B Gene

Genomics for DYRK1B Gene

GeneHancer (GH) Regulatory Elements for DYRK1B Gene

Promoters and enhancers for DYRK1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I039831 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 783 3.6 HDGF PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 E2F8 DYRK1B HNRNPL SNRPA FBL ZNF780B AKT2 RN7SL566P ZNF780A COQ8B PLEKHG2
GH19I040579 Enhancer 0.9 ENCODE dbSUPER 7.6 -746.0 -746029 0.8 HDAC1 MEIS2 PKNOX1 TEAD4 ZNF316 SCRT2 NFE2 MAFK ZNF362 RNF2 DYRK1B SHKBP1 LTBP4
GH19I039843 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.4 -11.3 -11309 4 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B FBL HNRNPL SNRPA ENSG00000269843 ZNF780B AKT2 SUPT5H PSMC4 ITPKC EID2B
GH19I039830 Enhancer 0.7 ENCODE dbSUPER 0.8 +4.1 4134 0.1 HIC1 SCRT1 SCRT2 SIN3A MIR6719 DYRK1B
GH19I039823 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 +9.3 9317 2.7 HDGF PKNOX1 ZNF493 SIN3A FEZF1 ZNF2 YY1 ETS1 ZNF121 GLIS2 GC19M039822 ZNF780B HNRNPL SNRPA FBL AKT2 ITPKC ZNF780A PAK4 ENSG00000269688
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DYRK1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYRK1B gene promoter:

Genomic Locations for DYRK1B Gene

Genomic Locations for DYRK1B Gene
chr19:39,825,347-39,834,233
(GRCh38/hg38)
Size:
8,887 bases
Orientation:
Minus strand
chr19:40,315,990-40,324,841
(GRCh37/hg19)

Genomic View for DYRK1B Gene

Genes around DYRK1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK1B Gene

Proteins for DYRK1B Gene

  • Protein details for DYRK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y463-DYR1B_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Protein Accession:
    Q9Y463
    Secondary Accessions:
    • O75258
    • O75788
    • O75789

    Protein attributes for DYRK1B Gene

    Size:
    629 amino acids
    Molecular mass:
    69198 Da
    Quaternary structure:
    • Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
    SequenceCaution:
    • Sequence=AAC28914.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK1B Gene

Selected DME Specific Peptides for DYRK1B Gene

Q9Y463:
  • HDTEMKYYIVHLK
  • YDLAIDMWSLGCILVEMHTGEPLFSG
  • FRGVSLNLTRK
  • IVEVLGIPPA
  • LSYNLYDLLRNT
  • IGKGSFGQV
  • DLIKTYKHIN
  • NPKRSAIKI
  • QAPKARK

Post-translational modifications for DYRK1B Gene

  • Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.

Domains & Families for DYRK1B Gene

Gene Families for DYRK1B Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DYRK1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y463

UniProtKB/Swiss-Prot:

DYR1B_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK1B: view

Function for DYRK1B Gene

Molecular function for DYRK1B Gene

GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse homolog,expressed in muscle and testis,involved in the regulation of nuclear functions
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by RANBP9.
UniProtKB/Swiss-Prot Function:
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Enzyme Numbers (IUBMB) for DYRK1B Gene

Gene Ontology (GO) - Molecular Function for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11980910
GO:0004672 protein kinase activity IDA,TAS 11980910
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK1B: view
genes like me logo Genes that share phenotypes with DYRK1B: view

Human Phenotype Ontology for DYRK1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DYRK1B Gene

MGI Knock Outs for DYRK1B:

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for DYRK1B Gene

Localization for DYRK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK1B gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA --
genes like me logo Genes that share ontologies with DYRK1B: view

Pathways & Interactions for DYRK1B Gene

genes like me logo Genes that share pathways with DYRK1B: view

Pathways by source for DYRK1B Gene

3 Cell Signaling Technology pathways for DYRK1B Gene

SIGNOR curated interactions for DYRK1B Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11980910
GO:0007520 myoblast fusion IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 11980910
genes like me logo Genes that share ontologies with DYRK1B: view

Drugs & Compounds for DYRK1B Gene

(8) Drugs for DYRK1B Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0
AZ191 Pharma DYRK1B inhibitor,potent and selective 0
ID-8 Pharma 0
Harmine Pharma Potent and selective DYRK1A inhibitor 1
INDY Pharma Dyrk1A and Dyrk1B inhibitor, selective, DYRK1A/B inhibitor 0

(5) Additional Compounds for DYRK1B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(3) Tocris Compounds for DYRK1B Gene

Compound Action Cas Number
Harmine Potent and selective DYRK1A inhibitor 442-51-3
INDY DYRK1A/B inhibitor 1169755-45-6
ProINDY DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997) 719277-30-2

(2) ApexBio Compounds for DYRK1B Gene

Compound Action Cas Number
AZ191 DYRK1B inhibitor,potent and selective
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK1B: view

Drug Products

Transcripts for DYRK1B Gene

Unigene Clusters for DYRK1B Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1B Gene

No ASD Table

Relevant External Links for DYRK1B Gene

GeneLoc Exon Structure for
DYRK1B
ECgene alternative splicing isoforms for
DYRK1B

Expression for DYRK1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYRK1B Gene

mRNA differential expression in normal tissues according to GTEx for DYRK1B Gene

This gene is overexpressed in Muscle - Skeletal (x6.6) and Testis (x5.6).

Protein differential expression in normal tissues from HIPED for DYRK1B Gene

This gene is overexpressed in Blymphocyte (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYRK1B Gene



Protein tissue co-expression partners for DYRK1B Gene

NURSA nuclear receptor signaling pathways regulating expression of DYRK1B Gene:

DYRK1B

SOURCE GeneReport for Unigene cluster for DYRK1B Gene:

Hs.130988

mRNA Expression by UniProt/SwissProt for DYRK1B Gene:

Q9Y463-DYR1B_HUMAN
Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.

Evidence on tissue expression from TISSUES for DYRK1B Gene

  • Muscle(4.6)
  • Pancreas(4.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DYRK1B Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
Organs:
Head and neck:
  • ear
Thorax:
  • heart
Abdomen:
  • duodenum
  • intestine
  • liver
  • small intestine
General:
  • blood vessel
genes like me logo Genes that share expression patterns with DYRK1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DYRK1B Gene

Orthologs for DYRK1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK1B 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia DYRK1B 34 33
  • 95.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DYRK1B 34 33
  • 94.01 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dyrk1b 33
  • 92.76 (n)
mouse
(Mus musculus)
Mammalia Dyrk1b 33 16 34
  • 92.63 (n)
oppossum
(Monodelphis domestica)
Mammalia DYRK1B 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK1B 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYRK1B 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk1a.2 33
  • 70.15 (n)
zebrafish
(Danio rerio)
Actinopterygii dyrk1b 33 34
  • 73.95 (n)
psmb6 33
fruit fly
(Drosophila melanogaster)
Insecta mnb 35 34
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-1 35 34
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 34 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1202 34
  • 73 (a)
OneToMany
Species where no ortholog for DYRK1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK1B Gene

ENSEMBL:
Gene Tree for DYRK1B (if available)
TreeFam:
Gene Tree for DYRK1B (if available)

Paralogs for DYRK1B Gene

Paralogs for DYRK1B Gene

(5) SIMAP similar genes for DYRK1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DYRK1B: view

Variants for DYRK1B Gene

Sequence variations from dbSNP and Humsavar for DYRK1B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs367643250 pathogenic, Abdominal obesity-metabolic syndrome 3, Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812] 39,830,443(-) G/A coding_sequence_variant, missense_variant
rs556237495 benign, Abnormality of neuronal migration 39,828,479(-) C/A/T coding_sequence_variant, missense_variant
rs587777380 pathogenic, Abdominal obesity-metabolic syndrome 3, Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812] 39,830,478(-) T/G coding_sequence_variant, missense_variant
VAR_040457 A metastatic melanoma sample p.Gln275Arg
rs78838108 likely-benign, not specified 39,827,594(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for DYRK1B Gene

Variant ID Type Subtype PubMed ID
esv2758760 CNV gain 17122850
nsv9725 CNV gain+loss 18304495

Variation tolerance for DYRK1B Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYRK1B Gene

Human Gene Mutation Database (HGMD)
DYRK1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK1B Gene

Disorders for DYRK1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for DYRK1B Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DYR1B_HUMAN
  • Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269 PubMed:24827035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DYRK1B

genes like me logo Genes that share disorders with DYRK1B: view

No data available for Genatlas for DYRK1B Gene

Publications for DYRK1B Gene

  1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PMID: 9918863) Leder S … Becker W (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PMID: 10910078) Lee K … Friedman E (Cancer research 2000) 3 4 22 58
  3. A form of the metabolic syndrome associated with mutations in DYRK1B. (PMID: 24827035) Keramati AR … Mani A (The New England journal of medicine 2014) 3 4 58
  4. The kinase Mirk is a potential therapeutic target in osteosarcoma. (PMID: 20042639) Yang C … Duan Z (Carcinogenesis 2010) 3 22 58
  5. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. (PMID: 19633423) Gao J … Haura EB (Cancer biology & therapy 2009) 3 22 58

Products for DYRK1B Gene

Sources for DYRK1B Gene

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