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Aliases for DYRK1B Gene

Aliases for DYRK1B Gene

  • Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B 2 3 5
  • Minibrain-Related Kinase 2 3 4
  • Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2 3
  • Mirk Protein Kinase 3 4
  • MIRK 3 4
  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B 2
  • Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B 3
  • EC 2.7.12.1 4
  • EC 2.7.12 61
  • AOMS3 3

External Ids for DYRK1B Gene

Previous GeneCards Identifiers for DYRK1B Gene

  • GC19M040957
  • GC19M040707
  • GC19M044992
  • GC19M045007
  • GC19M040316
  • GC19M036763

Summaries for DYRK1B Gene

Entrez Gene Summary for DYRK1B Gene

  • This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DYRK1B Gene

DYRK1B (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B) is a Protein Coding gene. Diseases associated with DYRK1B include Abdominal Obesity-Metabolic Syndrome 3 and Abdominal Obesity-Metabolic Syndrome. Among its related pathways are Neuroscience and Apoptosis and Autophagy. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot for DYRK1B Gene

  • Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Tocris Summary for DYRK1B Gene

  • Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are conserved serine/threonine kinases. DYRKs have been implicated in cell survival, proliferation and differentiation, and in the pathology of Down Syndrome and Alzheimer's disease.

Gene Wiki entry for DYRK1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYRK1B Gene

Genomics for DYRK1B Gene

Regulatory Elements for DYRK1B Gene

Enhancers for DYRK1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F040579 0.8 ENCODE 7.6 -746.0 -746030 0.8 PKNOX1 TAL1 RAD21 YY1 ZNF316 SCRT2 HNF4G NFE2 MAFK ZNF362 DYRK1B SHKBP1 LTBP4
GH19F039831 1.1 ENCODE 0.8 +0.8 783 3.6 HDGF PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 FOS SNRPA FBL RN7SL566P ENSG00000269688 SERTAD3 ENSG00000205041 ENSG00000269069 ENSG00000268366 ITPKC COQ8B
GH19F039843 1.1 ENCODE 0.4 -11.3 -11309 4.0 HDGF ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SNRPA ENSG00000269843 FBL LGALS14 ENSG00000269188 LOC105372399 ENSG00000269792 ENSG00000269172 LOC100129935 RPS16
GH19F039830 0.5 ENCODE 0.8 +4.1 4135 0.1 HIC1 SCRT1 SCRT2 DYRK1B MIR6719
GH19F039839 0.9 ENCODE 0.4 -5.7 -5713 1.5 HDAC1 ATF1 TBL1XR1 CREM EGR2 CEBPB CREB3 MEF2D ZSCAN16 SMARCA4 DYRK1B FBL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DYRK1B on UCSC Golden Path with GeneCards custom track

Promoters for DYRK1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044345 533 1401 HDGF PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 FOS

Transcription factor binding sites by QIAGEN in the DYRK1B gene promoter:

Genomic Location for DYRK1B Gene

Chromosome:
19
Start:
39,825,347 bp from pter
End:
39,834,233 bp from pter
Size:
8,887 bases
Orientation:
Minus strand

Genomic View for DYRK1B Gene

Genes around DYRK1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYRK1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYRK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYRK1B Gene

Proteins for DYRK1B Gene

  • Protein details for DYRK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y463-DYR1B_HUMAN
    Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Protein Accession:
    Q9Y463
    Secondary Accessions:
    • O75258
    • O75788
    • O75789

    Protein attributes for DYRK1B Gene

    Size:
    629 amino acids
    Molecular mass:
    69198 Da
    Quaternary structure:
    • Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Interacts with DCAF7.
    SequenceCaution:
    • Sequence=AAC28914.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DYRK1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYRK1B Gene

Selected DME Specific Peptides for DYRK1B Gene

Q9Y463:
  • HDTEMKYYIVHLK
  • YDLAIDMWSLGCILVEMHTGEPLFSG
  • FRGVSLNLTRK
  • IVEVLGIPPA
  • LSYNLYDLLRNT
  • IGKGSFGQV
  • DLIKTYKHIN
  • NPKRSAIKI
  • QAPKARK

Post-translational modifications for DYRK1B Gene

  • Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DYRK1B (DYRK1B)
  • Abcam antibodies for DYRK1B

Domains & Families for DYRK1B Gene

Suggested Antigen Peptide Sequences for DYRK1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y463

UniProtKB/Swiss-Prot:

DYR1B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
genes like me logo Genes that share domains with DYRK1B: view

Function for DYRK1B Gene

Molecular function for DYRK1B Gene

GENATLAS Biochemistry:
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse homolog,expressed in muscle and testis,involved in the regulation of nuclear functions
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by RANBP9.
UniProtKB/Swiss-Prot Function:
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).

Enzyme Numbers (IUBMB) for DYRK1B Gene

Gene Ontology (GO) - Molecular Function for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11980910
GO:0004672 protein kinase activity IDA,TAS 11980910
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DYRK1B: view
genes like me logo Genes that share phenotypes with DYRK1B: view

Human Phenotype Ontology for DYRK1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DYRK1B Gene

MGI Knock Outs for DYRK1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for DYRK1B

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DYRK1B Gene

Localization for DYRK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYRK1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYRK1B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with DYRK1B: view

Pathways & Interactions for DYRK1B Gene

genes like me logo Genes that share pathways with DYRK1B: view

Pathways by source for DYRK1B Gene

3 Cell Signaling Technology pathways for DYRK1B Gene

SIGNOR curated interactions for DYRK1B Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DYRK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,TAS 11980910
GO:0007520 myoblast fusion IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 11980910
genes like me logo Genes that share ontologies with DYRK1B: view

Drugs & Compounds for DYRK1B Gene

(8) Drugs for DYRK1B Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
AZ191 Pharma DYRK1B inhibitor,potent and selective 0
ID-8 Pharma 0
Harmine Pharma Potent and selective DYRK1A inhibitor 1
INDY Pharma Dyrk1A and Dyrk1B inhibitor, selective, DYRK1A/B inhibitor 0

(5) Additional Compounds for DYRK1B Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
AZ 191
1594092-37-1
TC-S 7004
1386979-55-0
TG 003
719277-26-6

(5) Tocris Compounds for DYRK1B Gene

Compound Action Cas Number
AZ 191 Potent DYRK1B inhibitor 1594092-37-1
Harmine Potent and selective DYRK1A inhibitor 442-51-3
INDY DYRK1A/B inhibitor 1169755-45-6
TC-S 7004 Potent and selective DYRK1A/B inhibitor 1386979-55-0
TG 003 Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B 719277-26-6

(2) ApexBio Compounds for DYRK1B Gene

Compound Action Cas Number
AZ191 DYRK1B inhibitor,potent and selective
ID-8 147591-46-6
genes like me logo Genes that share compounds with DYRK1B: view

Transcripts for DYRK1B Gene

Unigene Clusters for DYRK1B Gene

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1B Gene

No ASD Table

Relevant External Links for DYRK1B Gene

GeneLoc Exon Structure for
DYRK1B
ECgene alternative splicing isoforms for
DYRK1B

Expression for DYRK1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DYRK1B Gene

mRNA differential expression in normal tissues according to GTEx for DYRK1B Gene

This gene is overexpressed in Muscle - Skeletal (x6.6) and Testis (x5.6).

Protein differential expression in normal tissues from HIPED for DYRK1B Gene

This gene is overexpressed in Blymphocyte (65.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYRK1B Gene



Protein tissue co-expression partners for DYRK1B Gene

NURSA nuclear receptor signaling pathways regulating expression of DYRK1B Gene:

DYRK1B

SOURCE GeneReport for Unigene cluster for DYRK1B Gene:

Hs.130988

mRNA Expression by UniProt/SwissProt for DYRK1B Gene:

Q9Y463-DYR1B_HUMAN
Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
genes like me logo Genes that share expression patterns with DYRK1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DYRK1B Gene

Orthologs for DYRK1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DYRK1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYRK1B 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia DYRK1B 34 35
  • 95.5 (n)
cow
(Bos Taurus)
Mammalia DYRK1B 34 35
  • 94.01 (n)
rat
(Rattus norvegicus)
Mammalia Dyrk1b 34
  • 92.76 (n)
mouse
(Mus musculus)
Mammalia Dyrk1b 34 16 35
  • 92.63 (n)
oppossum
(Monodelphis domestica)
Mammalia DYRK1B 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYRK1B 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYRK1B 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dyrk1a.2 34
  • 70.15 (n)
zebrafish
(Danio rerio)
Actinopterygii dyrk1b 34 35
  • 73.95 (n)
psmb6 34
fruit fly
(Drosophila melanogaster)
Insecta mnb 36 35
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea mbk-1 36 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 35 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1202 35
  • 73 (a)
OneToMany
Species where no ortholog for DYRK1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYRK1B Gene

ENSEMBL:
Gene Tree for DYRK1B (if available)
TreeFam:
Gene Tree for DYRK1B (if available)

Paralogs for DYRK1B Gene

(5) SIMAP similar genes for DYRK1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DYRK1B: view

Variants for DYRK1B Gene

Sequence variations from dbSNP and Humsavar for DYRK1B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs367643250 Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812], Pathogenic 39,830,443(+) ACTGC(A/G)CACGA upstream-variant-2KB, reference, missense
rs587777380 Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812], Pathogenic 39,830,478(+) AACCA(G/T)GGTTC upstream-variant-2KB, reference, missense
VAR_040457 A metastatic melanoma sample
rs556237495 Benign 39,828,479(+) CGAGA(A/C/T)GCCGC reference, missense
rs11083539 -- 39,835,040(+) CTGAA(C/T)AGAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DYRK1B Gene

Variant ID Type Subtype PubMed ID
esv2758760 CNV gain 17122850
nsv9725 CNV gain+loss 18304495

Variation tolerance for DYRK1B Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYRK1B Gene

Human Gene Mutation Database (HGMD)
DYRK1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYRK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYRK1B Gene

Disorders for DYRK1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for DYRK1B Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
abdominal obesity-metabolic syndrome 3
  • central obesity, type 2 diabetes, hypertension, and early-onset coronary artery disease
abdominal obesity-metabolic syndrome
  • metabolic syndrome x
chronic cervicitis
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DYR1B_HUMAN
  • Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269 PubMed:24827035}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DYRK1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYRK1B
genes like me logo Genes that share disorders with DYRK1B: view

No data available for Genatlas for DYRK1B Gene

Publications for DYRK1B Gene

  1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PMID: 9918863) Leder S. … Becker W. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PMID: 10910078) Lee K. … Friedman E. (Cancer Res. 2000) 3 4 22 64
  3. A form of the metabolic syndrome associated with mutations in DYRK1B. (PMID: 24827035) Keramati A.R. … Mani A. (N. Engl. J. Med. 2014) 3 4 64
  4. The kinase Mirk is a potential therapeutic target in osteosarcoma. (PMID: 20042639) Yang C. … Duan Z. (Carcinogenesis 2010) 3 22 64
  5. Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells. (PMID: 19633423) Gao J. … Haura E.B. (Cancer Biol. Ther. 2009) 3 22 64

Products for DYRK1B Gene

Sources for DYRK1B Gene

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