Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYRK1B Gene

protein-coding   GIFtS: 61
GCID: GC19M040316

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...
  10 related diseases
at
MalaCards
 

Aliases
for DYRK1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B1 2     Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B2
Minibrain-Related Kinase1 2 3     EC 2.7.12.13
MIRK2 3 5     EC 2.7.128
Mirk Protein Kinase2 3     

External Ids:    HGNC: 30921   Entrez Gene: 91492   Ensembl: ENSG000001052047   OMIM: 6045565   UniProtKB: Q9Y4633   

Export aliases for DYRK1B gene to outside databases

Previous GC identifers: GC19M040957 GC19M040707 GC19M044992 GC19M045007 GC19M036763


Summaries
for DYRK1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DYRK1B Gene:
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal
and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear
functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced
exons within the catalytic domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for DYRK1B Gene: 
DYRK1B (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B) is a protein-coding gene. Diseases associated with DYRK1B include pancreatic ductal adenocarcinoma, and rhabdomyosarcoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463
Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances
the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon
carcinoma cell survival in mitogen-poor environments

Gene Wiki entry for DYRK1B Gene


Genomic Views
for DYRK1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYRK1B gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYRK1B promoter sequence
   Search SABiosciences Chromatin IP Primers for DYRK1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYRK1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

DYRK1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK1B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M040316:  view genomic region     (about GC identifiers)

Start:
 40,315,990 bp from pter      End:
 40,324,841 bp from pter
Size:
 8,852 bases      Orientation:
 minus strand

Proteins
for DYRK1B gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B  
Size: 629 amino acids; 69198 Da
Subunit: Dimer. Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A. Part of a complex consisting of RANBP9,
RAN, DYRK1B and COPS5. Interacts with DCAF7
Subcellular location: Nucleus
Sequence caution: Sequence=AAC28914.1; Type=Erroneous gene model prediction;
Secondary accessions: O75258 O75788 O75789
Alternative splicing: 3 isoforms:  Q9Y463-1   Q9Y463-2   Q9Y463-3   

Explore the universe of human proteins at neXtProt for DYRK1B: NX_Q9Y463

Explore proteomics data for DYRK1B at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required
    for dimerization
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y463

    • 4/9 DME Specific Peptides for DYRK1B (Q9Y463) (see all 9)
     QAPKARK  NPKRSAIKI  IGKGSFGQV  IVEVLGIPPA 

    DYRK1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DYRK1B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004705.1  NP_006474.1  NP_006475.1  

    ENSEMBL proteins: 
     ENSP00000469863   ENSP00000312789   ENSP00000472941   ENSP00000403182   ENSP00000471609  
     ENSP00000472861   ENSP00000221803  

    Human Recombinant Protein Products for DYRK1B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DYRK1B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DYRK1B
    GenScript Custom Purified and Recombinant Proteins Services for DYRK1B
    Novus Biologicals DYRK1B Proteins
    Novus Biologicals DYRK1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DYRK1B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    DYRK1B for ontologies           About GeneDecksing



    DYRK1B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DYRK1B
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DYRK1B 
    OriGene Antibodies for DYRK1B
    OriGene Custom Antibody Services for DYRK1B
    GenScript Custom Superior Antibodies Services for DYRK1B
    Novus Biologicals DYRK1B Antibodies
    Abcam antibodies for DYRK1B
    Cloud-Clone Corp. Antibodies for DYRK1B 
    ThermoFisher Antibody for DYRK1B
    LSBio Antibodies in human, mouse, rat for DYRK1B 

    Assay Products for DYRK1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DYRK1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DYRK1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DYRK1B 
    Cloud-Clone Corp. CLIAs for DYRK1B

    Protein Domains /
    Families
    for DYRK1B gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 
    Dyrk1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y463

    ProtoNet protein and cluster: Q9Y463

    UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    DYRK1B for domains           About GeneDecksing


    Function
    for DYRK1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYR1B_HUMAN, Q9Y463
    Function: Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances
    the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon
    carcinoma cell survival in mitogen-poor environments
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by RANBP9

         Genatlas biochemistry entry for DYRK1B:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B,Drosophila minibrain homolog,Dres27,mouse
    homolog,expressed in muscle and testis,involved in the regulation of nuclear functions

         Enzyme Numbers (IUBMB): EC 2.7.122 EC 2.7.12.11

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA11980910
    GO:0004672protein kinase activity IDA11980910
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
         
    DYRK1B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DYRK1B:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  High actin ratio cells  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DYRK1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DYRK1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DYRK1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DYRK1B 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYRK1B
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DYRK1B (see all 28):
    hsa-miR-539 hsa-miR-1263 hsa-miR-148b hsa-miR-15a hsa-miR-765 hsa-miR-503 hsa-miR-3605-5p hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmid: DYRK1B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DYRK1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYRK1B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DYRK1B
    Sirion Biotech Customized adenovirus for overexpression of DYRK1B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DYRK1B (see all 18)
    OriGene ORF clones in mouse, rat for DYRK1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DYRK1B (NM_006483)
    Sino Biological Human cDNA Clone for DYRK1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYRK1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1B
    Sirion Biotech Customized lentivirus for stable overexpression of DYRK1B 
                         Customized lentivirus expression plasmids for stable overexpression of DYRK1B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DYRK1B
    Search LifeMap BioReagents cell lines for DYRK1B
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B


    Pathways & Interactions
    for DYRK1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DYRK1B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    		Neuroscience
    2Apoptosis and Autophagy
    		Apoptosis and Autophagy
    3Glucose / Energy Metabolism
    		Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for DYRK1B
        Apoptosis and Autophagy
    Neuroscience
    Glucose / Energy Metabolism




    DYRK1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DYRK1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/21 Interacting proteins for DYRK1B (Q9Y4631, 2, 3 ENSP000003127894) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP9Q96S591, 3, ENSP000000116194EBI-634187,EBI-636085 I2D: score=5 STRING: ENSP00000011619
    HIPK2Q9H2X62, 3MINT-8085067 I2D: score=1 
    DCAF7P619622, 3, ENSP000003083444MINT-8085204 MINT-8085121 I2D: score=4 STRING: ENSP00000308344
    HNF1AP208231, 3, ENSP000002575554EBI-634187,EBI-636034 I2D: score=2 STRING: ENSP00000257555
    MAP2K3P467341, 3, ENSP000003450834EBI-634187,EBI-602462 I2D: score=2 STRING: ENSP00000345083
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11980910
    GO:0007520myoblast fusion IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IDA11980910

    DYRK1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for DYRK1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DYRK1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DYRK1B (DYR1B)

    2 HMDB Compounds for DYRK1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for DYRK1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 57.4 7 17583556 (1), 19633423 (1), 16257974 (1)
    serine 54.5 7 17583556 (1), 19633423 (1), 16257974 (1)
    tyrosine 36.5 9 19633423 (2), 17583556 (1)
    phosphatidylinositol 35.6 3 19852933 (1), 7528205 (1)

    Search CenterWatch for drugs/clinical trials and news about DYRK1B / DYR1B

    Transcripts
    for DYRK1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DYRK1B gene (3 alternative transcripts): 
    NM_004714.1  NM_006483.1  NM_006484.1  

    Unigene Cluster for DYRK1B:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
    Hs.130988  [show with all ESTs]
    Unigene Representative Sequence: Y17999
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593685 ENST00000323039(uc002omj.3) ENST00000597639 ENST00000430012(uc002omk.3 uc002oml.3)
    ENST00000601696 ENST00000600611 ENST00000601972 ENST00000348817(uc002omi.3)

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYRK1B
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DYRK1B (see all 28):
    hsa-miR-539 hsa-miR-1263 hsa-miR-148b hsa-miR-15a hsa-miR-765 hsa-miR-503 hsa-miR-3605-5p hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmid: DYRK1B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DYRK1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYRK1B
    Clone
    Products:             		 OriGene clones in human, mouse for DYRK1B (see all 18)
    OriGene ORF clones in mouse, rat for DYRK1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DYRK1B (NM_006483)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYRK1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1B
    Sirion Biotech Customized lentivirus for stable overexpression of DYRK1B 
                         Customized lentivirus expression plasmids for stable overexpression of DYRK1B 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for DYRK1B
    OriGene qSTAR qPCR primer pairs in human, mouse for DYRK1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYRK1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYRK1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYRK1B

    Additional mRNA sequence: 

    AF205861.1 AK074971.1 AK302127.1 BC009688.1 BC018751.1 BC025291.1 Y17999.1 

    6 DOTS entries:

    DT.91763665  DT.100751337  DT.100751336  DT.101961855  DT.91736675  DT.100664884 

    24/126 AceView cDNA sequences (see all 126):

    NM_004714 AL525248 BC025291 BQ897084 CD622782 BM726424 BQ884039 NM_006484 
    AI803954 AF205861 AL530872 CB216229 AK074971 BX115330 CR611407 BU156847 
    NM_006483 BC009688 CR620266 Y17999 BM681591 BC018751 AI669060 BG831814 

    GeneLoc Exon Structure


    Expression
    for DYRK1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYRK1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAGTATG
    DYRK1B Expression
    About this image


    See DYRK1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYRK1B

    SOURCE GeneReport for Unigene cluster: Hs.130988

    UniProtKB/Swiss-Prot: DYR1B_HUMAN, Q9Y463
    Tissue specificity: Highest expression in skeletal muscle, testis, heart and brain with little expression in colon
    or lung. Expressed in a variety of tumor cell lines

        SABiosciences Custom PCR Arrays for DYRK1B
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for DYRK1B
    OriGene qSTAR qPCR primer pairs in human, mouse for DYRK1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYRK1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYRK1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYRK1B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B

    Orthologs
    for DYRK1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DYRK1B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dyrk1b1 , 5 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 92.63(n)1
    97.3(a)1    		   7 (16.67 cM)5
    135491  NM_001037957.21  NP_001033046.11 
     281794695 
    lizard
    (Anolis carolinensis)    		 Reptilia DYRK1B6
    		 Uncharacterized protein
    		 62(a)
    		 1 ↔ 1
    		 GL343276.1(1707937-1720413)
    zebrafish
    (Danio rerio)    		 Actinopterygii psmb62 Transcribed sequence with moderate similarity to protein more 83.66(n)    CK143492.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mnb3 circadian rhythm protein
    serine/threonine kinase    		 76(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mbk-11 , 3 serine/threonine kinase (2 domains)3
    Protein MBK-11    		 60(a)3
    55.01(n)1
    59.64(a)1    		   X(14855249-14860148)3
    1815781  NM_078059.31  NP_510460.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes YAK1(YJL141C)4 Serine-threonine protein kinase; component of a glucose-sensing more   --   10(150390-147967) 853300  NP_012394.1 


    ENSEMBL Gene Tree for DYRK1B (if available)
    TreeFam Gene Tree for DYRK1B (if available)

    Paralogs
    for DYRK1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYRK1B gene
    DYRK1A2  DYRK22  DYRK32  HIPK12  DYRK42  HIPK32  HIPK42  HIPK22  
    5 SIMAP similar genes for DYRK1B using alignment to 3 protein entries:     DYR1B_HUMAN (see all proteins):
    MNB/DYRK    DYRK1A    DYRK3    DYRK2    DYRK4

    DYRK1B for paralogs           About GeneDecksing



    Genomic Variants
    for DYRK1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 SNPs in DYRK1B are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0404574
    		A metastatic melanoma sample4--see VAR_0404572 Q R mis40--------
    rs1840424901,2
    		--40315569(+) GTGGGA/GACAGA 3 -- ds50010--------
    rs769655171,2
    		F--40315684(+) GCTAAG/CTCTGC 3 -- ds50012Minor allele frequency- C:0.02NA EA 240
    rs1506911481,2
    		--40315699(+) GCCCCA/GGCTTA 3 -- ds50010--------
    rs1878189021,2
    		--40315755(+) CCTTTC/TAGGGT 3 -- ds50010--------
    rs1129578701,2
    		F--40315806(+) TCCACG/CATCTA 3 -- ds50013Minor allele frequency- C:0.06CSA WA 122
    rs129752311,2
    		C,F--40315835(+) CAGACC/ATGCAG 3 -- ds50015Minor allele frequency- A:0.10NA EA 246
    rs72549141,2
    		C,F,A--40315841(+) TGCAGC/ACTCAT 3 -- ds500113Minor allele frequency- A:0.50NA WA CSA EA 375
    rs743420611,2
    		C,F--40315949(+) GGGTCG/AGGTGA 3 -- ds50014Minor allele frequency- A:0.08CSA WA NA 241
    rs2006810611,2
    		C--40316461(+) TCATCC/TGAGTC 6 Q R mis10--------

    HapMap Linkage Disequilibrium report for DYRK1B (40315990 - 40324841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DYRK1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911696CNV Loss21882294
    nsv9725CNV Gain+Loss18304495
    dgv1082e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYRK1B
    DNA2.0 Custom Variant and Variant Library Synthesis for DYRK1B

    Disorders / Diseases
    for DYRK1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 604556    OMIM disorders: --

    10 diseases for DYRK1B:    About MalaCards
    pancreatic ductal adenocarcinoma    rhabdomyosarcoma    down syndrome    osteosarcoma
    pancreatitis    pancreatic cancer    colon cancer    adenocarcinoma
    lung cancer    ovarian cancer


    DYRK1B for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for DYRK1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rhabdomyosarcoma 52.7 10 16707437 (8), 19633423 (1)
    tumors 10.5 12 19633423 (2), 12591926 (1), 10910078 (1), 16618736 (1) (see all 7)
    cancer 0 7 17583556 (3), 16618736 (1)


    Export disorders for DYRK1B gene to outside databases

    Publications
    for DYRK1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYRK1B gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with DYRK1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases. (PubMed id 9918863)1, 2, 3, 9 Leder S.... Becker W. (1999)
    2. Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. (PubMed id 10910078)1, 2, 9 Lee K.... Friedman E. (2000)
    3. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PubMed id 14593110)1, 2 Skurat A.V. and Dietrich A.D. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran- binding protein M. (PubMed id 14500717)1, 2 Zou Y.... Friedman E. (2003)
    7. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)1, 2 Lim S....Friedman E. (2002)
    8. The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. (PubMed id 12384504)1, 9 Lim S....Friedman E. (2002)
    9. The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma. (PubMed id 16618736)1, 9 Deng X....Friedman E. (2006)
    10. The kinase Mirk is a potential therapeutic target in osteosarcoma. (PubMed id 20042639)1, 9 Yang C....Duan Z. (2010)

    External Searches for DYRK1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DYRK1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9149 HGNC: 3092 AceView: DYRK1B Ensembl:ENSG00000105204 euGenes: HUgn9149
    ECgene: DYRK1B H-InvDB: DYRK1B

    Other Databases showing DYRK1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DYRK1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYRK1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DYRK1B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DYRK1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DYRK1B gene:
    Search GeneIP for patents involving DYRK1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DYRK1B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of DYRK1B
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DYRK1B   OriGene RNAi products in human, mouse, rat for DYRK1B  
     OriGene qPCR primer pairs and template standards for DYRK1B   OriGene Protein Over-expression Lysate for DYRK1B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DYRK1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for DYRK1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DYRK1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DYRK1B   OriGene Custom Protein Services for DYRK1B  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYRK1B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYRK1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYRK1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYRK1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYRK1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYRK1B
     GenScript Custom Purified and Recombinant Proteins Services for DYRK1B GenScript cDNA clones with any tag delivered in your preferred vector for DYRK1B
     GenScript Custom Assay Services for DYRK1B GenScript Custom Superior Antibodies Services for DYRK1B
     GenScript Custom overexpressing Cell Line Services for DYRK1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for DYRK1B 

     Regulatory tfbs in DYRK1B promoter
     Search Chromatin IP Primers for DYRK1B
     RT2 qPCR Primer Assay in human, mouse, rat DYRK1B
     GNC Network for DYRK1B
     SABiosciences Custom PCR Arrays for DYRK1B
     Search Tocris compounds for DYRK1B (DYR1B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for DYRK1B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DYRK1B antibodies
     DYRK1B proteins
     DYRK1B lysates
     Antibodies for DYRK1B
     See all of Abcam's Antibodies, Kits and Proteins for DYRK1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DYRK1B
     Antibodies for DYRK1B
     ELISAs for DYRK1B
     CLIAs for DYRK1B
     Search LifeMap BioReagents cell lines for DYRK1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1B
     SwitchGear 3'UTR luciferase reporter plasmids for DYRK1B
     SwitchGear Promoter luciferase reporter plasmids for DYRK1B
     ThermoFisher Antibody for DYRK1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DYRK1B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DYRK1B
    Customized:
     lentivirus for stable overexpression of DYRK1B
     lentivirus expression plasmids for stable overexpression of DYRK1B
     adenovirus for overexpression of DYRK1B
     LSBio Antibodies in human, mouse, rat for DYRK1B
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DYRK1B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4