DYRK1A Gene protein-coding GIFtS : 71 GCID: GC21 P038739
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated... DYRK1, DYRK, MNBH )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor DYRK1A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
15 RNAdb , and/or 11 Nature :405,311-319 and CroW21)About This Section Aliases Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A 1 2 Dual-Specificity Tyrosine-Y-Phosphorylation Regulated Kinase, EC 2.7.111 MNBH1 2 3 5 MRD72 DYRK1 2 3 Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A2 MNB2 3 5 Mnb Protein Kinase Homolog Hp862 DYRK11 2 MNB/DYRK Protein Kinase2 Dual Specificity YAK1-Related Kinase2 3 Serine/Threonine Kinase MNB2 Protein Kinase Minibrain Homolog2 3 Serine/Threonine-Specific Protein Kinase2 HP862 3 EC 2.7.12.13 hMNB2 3 EC 2.7.128
Export aliases for DYRK1A gene to outside databases Previous GC identifers: GC21P035317 GC21P037659 GC21P037712 GC21P037660 GC21P037661 GC21P024215
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor DYRK1A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DYRK1A Gene: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. Thismember contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and ahighly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine andtyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may beinvolved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It islocalized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate genefor learning defects associated with Down syndrome. Alternative splicing of this gene generates severaltranscript variants differing from each other either in the 5' UTR or in the 3' coding region. These variantsencode at least five different isoforms. (provided by RefSeq, Jul 2008) GeneCards Summary for DYRK1A Gene: DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) is a protein-coding gene. Diseases associated with DYRK1A include down syndrome down syndrome critical region related super-pathways are Cell Cycle, Mitotic and G1/S Transition . GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity . An important paralog of this gene is DYRK2 . UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 Function : May play a role in a signaling pathway regulating nuclear functions of cell proliferation.Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2,FOXO1 and SIRT1 Gene Wiki entry for DYRK1A Gene
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor DYRK1A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
GC21P038739: GeneLoc Nature :405,311-319
Start: 38,739,236 bp from pter 24,367,732 bp from centromere
End: 38,887,680 bp from pter 24,464,002 bp from centromere
Size: 148,445 bases96,271 bases
Orientation: plus strandplus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor DYRK1A gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 See
protein sequence )Recommended Name: Size : 763 amino acids; 85584 DaSubunit : Interacts RAD54L2/ARIP4. Interacts with CRY2 (By similarity). Interacts with RANBP9. Interacts with WDR68Subcellular location : Nucleus speckleDevelopmental stage : Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Downsyndrome brain
5 PDB 3D structures from :2VX3 (3D) 2WO6 (3D) 3ANQ (3D) 3ANR (3D) 4AZE (3D) Secondary accessions : O60769 Q92582 Q92810 Q9UNM5Alternative splicing : 5 isoforms : Q13627-1 Q13627-2 Q13627-3 Q13627-4 Q13627-5 Explore the universe of human proteins at neXtProt for DYRK1A: NX_Q13627 Explore proteomics data for DYRK1A at MOPED Post-translational modifications:
UniProtKB: Autophosphorylated on tyrosine residues View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q13627 4/21 DME Specific Peptides for DYRK1A (Q13627 ) (see all 21 )DYRK1A Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (4 alternative transcripts): NP_001387.2 NP_567824.1 NP_569120.1 NP_569122.1 ENSEMBL proteins: ENSP00000342690 ENSP00000398483 ENSP00000412269 ENSP00000340373 ENSP00000381932 ENSP00000381929 ENSP00000319032 ENSP00000416089 ENSP00000407854 Reactome Protein details: Q13627 Human Recombinant Protein Products for DYRK1A: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing DYRK1A Antibody Products: Assay Products for DYRK1A:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for DYRK1A gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Dyrk1 subfamily 5 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q13627 ProtoNet protein and cluster: Q13627
UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 Domain : The polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028)Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamilySimilarity : Contains 1 protein kinase domainAbout GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor DYRK1A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: DYR1A_HUMAN, Q13627 Function : May play a role in a signaling pathway regulating nuclear functions of cell proliferation.Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2,FOXO1 and SIRT1 Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Inhibited by RANBP9
Genatlas biochemistry entry for DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1,Drosophila minibrain homolog Dres27,mouse homologubiquitously expressed at low levels in embryo,expressed in adult central nervous system-cortex,hippocampus,striatum and spinal cord) located in the Down syndrome critical region (DCR),involved inpost-embryonic neurogenesis,putatively overexpressed in Down syndrome and involved in the learning defect and inhypotonia Enzyme Numbers (IUBMB): EC 2.7.12 2 EC 2.7.12.1 1 Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004672 protein kinase activity
TAS 8769099 GO:0004674 protein serine/threonine kinase activity
ISS -- GO:0004712 protein serine/threonine/tyrosine kinase activity
IEA -- GO:0004713 protein tyrosine kinase activity
ISS -- GO:0004715 non-membrane spanning protein tyrosine kinase activity
IDA 9748265
About GeneDecksing Phenotypes: 5 GenomeRNAi human phenotypes for DYRK1A :7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dyrk1a) :About GeneDecksing Animal Models: MGI mouse knock-out Dyrk1a tm1Mla for DYRK1ACell Line GenScript Custom overexpressing Cell Line Services for DYRK1A Search LifeMap BioReagents cell lines for DYRK1A In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor DYRK1A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for DYRK1A About (see all 7 ) See pathways by source SuperPath Contained pathways About 1 Cell Cycle 2 Mitotic G1-G1/S phases 3 Translation Insulin regulation of translation 4 Hedgehog Signaling Pathway 5 Cell cycle Cell cycle (generic schema)
Pathways by source See SuperPaths Show all pathways 1 1 1 1 1 4 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DYRK1A STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/64 Interacting proteins for DYRK1A (Q13627 1 , 2 , 3 ENSP00000381932 4 via UniProtKB, MINT, STRING , and/or I2D (see all 64 )About this table Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor DYRK1A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for DYRK1A (DYR1A) 2 HMDB Compounds for DYRK1A About this table 1 DrugBank Compound for DYRK1A About this table 10 Novoseek inferred chemical compound relationships for DYRK1A gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
threonine
63.7
6
15780591 (1), 11828259 (1), 14990717 (1), 19016842 (1) (see
all 6 )
serine
52.2
4
11828259 (1), 14990717 (1), 19801542 (1), 19796173 (1)
tyrosine
49.9
47
17536841 (6), 19796173 (3), 12604362 (2), 19016842 (2) (see
all 17 )
glycogen
40.2
1
11311121 (1)
phosphotyrosine
21.3
10
17536841 (2)
leucine
11.7
2
8975710 (1), 9070862 (1)
arginine
8.37
4
10644696 (1), 14623875 (1), 11755526 (1)
proline
3.33
2
11311121 (1)
histidine
0
1
17536841 (1)
alanine
0
2
10644696 (1), 12604362 (1)
DYRK1A / DYR1A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor DYRK1A gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DYRK1A gene (5 alternative transcripts): NM_001396.3 NM_101395.2 NM_130436.2 NM_130438.2 NM_130437.2 Unigene Cluster for DYRK1A:
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Hs.368240 [show with all ESTs ] Unigene Representative Sequence: NM_130436 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000462274 ENST00000338785 (uc002ywg.1 uc002ywh.1 uc002ywi.3 uc002ywk.3 uc002ywm.3 uc011aei.2 )ENST00000455097 (uc010gno.1 ) ENST00000426672 ENST00000339659 (uc002ywj.3 )ENST00000398960 ENST00000498351 ENST00000398956 ENST00000321219 ENST00000451934 ENST00000455387 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB015282.1 AB015283.1 AB015284.1 AF108830.1 AJ001870.1 AJ001871.1 AK301752.1 BC030515.1 BC045802.1 BC065184.1 D85759.1 D86550.1 U52373.1 U58496.1 Z25423.1
9 DOTS entries : DT.97806866 DT.100791954
DT.449194 DT.92438592 DT.75101238 DT.121141919 DT.121141927 DT.92044861 DT.92438591 24/287 AceView cDNA sequences (see all 287 ):
BM975913 AI424886 BE790930 F04034 BM971404 AI076027 AL046760 AB015283 AA866036 AI149373 CN479966 Z44545 NM_130437 AI031728 AI391600 F12144 AA729988 AA932861 AI627548 AI190401 BF794263 AA306050 AA918140 Z45133 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1A (see all 6 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 SP1 : - SP2 : - - SP3 : - SP4 : - - - SP5 : - - - -
ECgene alternative splicing isoforms for DYRK1A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for DYRK1A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DYRK1A expression in normal human tissues
(normalized intensities) DYRK1A embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: CGGTCTTATGAbout this image
DYRK1A expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/4 selected tissues (see all 4 ) fully expand See DYRK1A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DYRK1A SOURCE GeneReport for Unigene cluster: Hs.368240 UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 Tissue specificity : Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidneySABiosciences Custom PCR Arrays for DYRK1A Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor DYRK1A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for DYRK1A gene from 9/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Dyrk1a1 5
dual-specificity tyrosine-(Y)-phosphorylation regulated more 1, 5
93.93(n) 1 99.21(a) 1
16 (55.30 cM) 5 13548 1 NM_007890.2 1 NP_031916.1 1 94570010 5
chicken Aves DYRK1A1
dual-specificity tyrosine-(Y)-phosphorylation regulated more
88.89(n) 97.61(a)
395233 NM_204550.1 NP_989881.1
lizard Reptilia DYRK1A6
dual-specificity tyrosine-(Y)-phosphorylation regu... 98(a)
1 ↔ 1
3(140718560-140857690)
African clawed frog Amphibia dyrk1a-prov2
dual-specificity tyrosine-(Y)-phosphorylation regulated more
79.47(n)
BC044104.1
zebrafish Actinopterygii dyrk1ab1
dual-specificity tyrosine-(Y)-phosphorylation regulated more
75.73(n) 84.12(a)
327466 XM_002664610.2 XP_002664656.1
fruit fly Insecta mnb3
circadian rhythm protein
82(a)
--
worm Secernentea mbk-13
serine/threonine kinase (2 domains)
70(a)
X(14855249-14860148) --
baker's yeast Saccharomycetes YAK16
Serine-threonine protein kinase; component of a gl... 18(a)
1 → many
X(147967-150390)
rice Liliopsida Os.143132
Oryza sativa (japonica cultivar-group) cDNA cloneJ more
78.14(n)
AK068489.1
ENSEMBL Gene Tree for DYRK1A (if available)TreeFam Gene Tree for DYRK1A (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor DYRK1A gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DYRK1A gene DYRK2 2 DYRK3 2 HIPK1 2 DYRK4 2 HIPK3 2 HIPK4 2 HIPK2 2 DYRK1B 2 15 SIMAP similar genes for DYRK1A using alignment to 4 protein entries: DYR1A_HUMAN (see all proteins ):MNB/DYRK DYRK1B NDUFA9 CDK7 DYRK4 MOK DYRK2 DYRK3 SRPK3 HIPK1 MAPK14 MARK4 HIPK2 CDK4 ULK1 About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor DYRK1A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 21 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for DYRK1A (38739236 - 38887680 bp)
Structural Variations Database of Genomic Variants (DGV) 2 variations for DYRK1A : About this table Human Gene Mutation Database (HGMD) : DYRK1A SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing DYRK1A
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor DYRK1A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 600855
OMIM disorders : --UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 Mental retardation, autosomal dominant 7 (MRD7) [MIM:614104]: A disease characterized by primarymicrocephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features,including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation ischaracterized by significantly below average general intellectual functioning associated with impairments inadaptative behavior and manifested during the developmental period. Note=The disease is caused by mutationsaffecting the gene represented in this entry 18 : About MalaCards down syndrome down syndrome critical region pick's disease microcephaly hypotonia intellectual disability alzheimer's disease mental retardation herpes simplex osteosarcoma dementia thyroiditis melanoma lung cancer pancreatitis endotheliitis neuronitis leukemia 2 diseases from the University of Copenhagen DISEASES database for DYRK1A :Down syndrome Intellectual disability About GeneDecksing Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 6 Novoseek inferred disease relationships for DYRK1A gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome
86
67
12618396 (4), 15694837 (3), 10812554 (3), 12814361 (2) (see
all 33 )
mental retardation
71.7
8
15906374 (1), 16959772 (1), 9918863 (1), 11877424 (1) (see
all 8 )
trisomy
45.4
7
11555628 (1), 16554754 (1), 19242551 (1)
memory impairment
41.3
4
17696169 (1), 17536841 (1)
alzheimers disease
37.6
8
19995442 (2), 18696092 (1), 17135279 (1), 19665384 (1) (see
all 5 )
neuropathology
36.6
1
12618396 (1)
Genetic Association Database (GAD): DYRK1A Human Genome Epidemiology (HuGE) Navigator: DYRK1A (2 documents) Export disorders for DYRK1A gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor DYRK1A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DYRK1A gene, integrated from 9 sources (see all 180 ):(articles sorted by number of sources associating them with DYRK1A) Utopia : connect your pdf to the dynamic
Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'. (PubMed id 8975710) 1 , 2 , 9(1996) DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort. (PubMed id 19995442) 1 , 4, 9(2009) Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. (PubMed id 10329007) 1 , 2 , 9(1999) Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2. (PubMed id 9284911) 1 , 3, 9(1997) Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21. (PubMed id 8769099) 1 , 2 , 9(1996) A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. (PubMed id 8872470) 1 , 2 , 9(1996) Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. (PubMed id 9037601) 1 , 2 , 9(1997) Genome-wide association study identifies single nucle otide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-d erived macrophages. (PubMed id 21364930) 1 , 4(2011) Intragenic deletion in DYRK1A leads to mental retarda tion and primary microcephaly. (PubMed id 21294719) 1 , 2 (2011) A genome-wide association study of the metabolic synd rome in Indian Asian men. (PubMed id 20694148) 1 , 4(2010)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for DYRK1A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing DYRK1A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing DYRK1A gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing DYRK1A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for DYRK1A gene: DYRK1A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor DYRK1A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYRK1A QIAGEN SeqTarget long-range PCR primers for resequencing DYRK1A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for DYRK1A
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1A
ThermoFisher Antibodies for DYRK1A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DYRK1A
Jump to Section...
Aliases for DYRK1A
Databases for DYRK1A
Disorders / Diseases for DYRK1A
Domains / Families for DYRK1A
Drugs / Compounds for DYRK1A
Expression for DYRK1A
Function for DYRK1A
Genomic Views for DYRK1A
Intellectual Property for DYRK1A
Orthologs for DYRK1A
Paralogs for DYRK1A
Pathways / Interactions for DYRK1A
Products for DYRK1A
Proteins for DYRK1A
Publications for DYRK1A
Search Box for DYRK1A
Summaries for DYRK1A
Transcripts for DYRK1A
Variants for DYRK1A
TOP
BOTTOM
GeneCards Homepage -
Last full update: 23 Oct 2013 -
Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014
View Random Gene
Category
Protein-coding
RNA genes
Genetic Loci
Pseudogenes
Gene clusters
Uncategorized
Any
Go
transforming growth factor, beta 1
GIFtS Group
High
Medium
Low
Any
Developed at the Crown Human Genome Center Department of Molecular Genetics
the Weizmann Institute of Science
Copyright © 1996-2014
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356980-web2.xennexinc.com
index build: 106 solr: 1.4
and Proteopedia 
for DYRK1A:
GeneGo (Thomson Reuters) Pathway for DYRK1A
Browse Tocris compounds for 
