Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DYRK1A Gene

protein-coding   GIFtS: 72
GCID: GC21P038739

Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated...


(Previous symbols: DYRK1, DYRK, MNBH)
  See DYRK1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A1 2     MRD72 5
MNBH1 2 3 5     Dual-Specificity Tyrosine-Y-Phosphorylation Regulated Kinase, EC 2.7.111
DYRK1 2 3     Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A2
MNB2 3 5     Mnb Protein Kinase Homolog Hp862
DYRK11 2     MNB/DYRK Protein Kinase2
Dual Specificity YAK1-Related Kinase2 3     Serine/Threonine Kinase MNB2
Protein Kinase Minibrain Homolog2 3     Serine/Threonine-Specific Protein Kinase2
HP862 3     EC 2.7.12.13
hMNB2 3     EC 2.7.128

External Ids:    HGNC: 30911   Entrez Gene: 18592   Ensembl: ENSG000001575407   OMIM: 6008555   UniProtKB: Q136273   

Export aliases for DYRK1A gene to outside databases

Previous GC identifers: GC21P035317 GC21P037659 GC21P037712 GC21P037660 GC21P037661 GC21P024215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DYRK1A Gene:
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This
member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a
highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and
tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be
involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is
localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene
for learning defects associated with Down syndrome. Alternative splicing of this gene generates several
transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants
encode at least five different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for DYRK1A Gene:
DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) is a protein-coding gene. Diseases associated with DYRK1A include mental retardation, autosomal dominant 7, and down syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is DYRK2.

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
Function: May play a role in a signaling pathway regulating nuclear functions of cell proliferation.
Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2,
FOXO1 and SIRT1

Gene Wiki entry for DYRK1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYRK1A gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DYRK1A promoter sequence

   Search Chromatin IP Primers for DYRK1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYRK1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.13   HGNC cytogenetic band: 21q22.13
Nature(405: 311-319) cytogenetic band:   21q22.13
DYRK1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYRK1A gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P038739:   GeneLoc Nature:405,311-319
Start:
38,738,092 bp from pter       24,367,732 bp from centromere
End:
38,889,753 bp from pter 24,464,002 bp from centromere
Size:
151,662 bases 96,271 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: D86550
genomic clones: pT1091 to pS165


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 (See protein sequence)
Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A  
Size: 763 amino acids; 85584 Da
Subunit: Interacts RAD54L2/ARIP4. Interacts with CRY2 (By similarity). Interacts with RANBP9. Interacts with WDR68
Developmental stage: Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down
syndrome brain
Selected PDB 3D structures from and Proteopedia for DYRK1A (see all 7):
2VX3 (3D)        2WO6 (3D)        3ANQ (3D)        3ANR (3D)        4AZE (3D)        4MQ1 (3D)    
Secondary accessions: O60769 Q92582 Q92810 Q9UNM5
Alternative splicing: 5 isoforms:  Q13627-1   Q13627-2   Q13627-3   Q13627-4   Q13627-5   

Explore the universe of human proteins at neXtProt for DYRK1A: NX_Q13627

Explore proteomics data for DYRK1A at MOPED

Post-translational modifications: 

  • Autophosphorylated on tyrosine residues1
  • Ubiquitination2 at Lys304
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DYRK1A (Q13627) (see all 21)
     QYSDRRQ  DQIQQPL  EAPTQVT  QAPKARK 


    See DYRK1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001387.2  NP_567824.1  NP_569120.1  NP_569122.1  

    ENSEMBL proteins: 
     ENSP00000342690   ENSP00000398483   ENSP00000412269   ENSP00000340373   ENSP00000381932  
     ENSP00000381929   ENSP00000319032   ENSP00000416089   ENSP00000407854  
    Reactome Protein details: Q13627

    DYRK1A Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant DYRK1A Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DYRK1A
    OriGene Protein Over-expression Lysate for DYRK1A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DYRK1A
    GenScript Custom Purified and Recombinant Proteins Services for DYRK1A
    Novus Biologicals DYRK1A Proteins
    Novus Biologicals DYRK1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DYRK1A

     
    Search eBioscience for Proteins for DYRK1A 

     
    antibodies-online proteins for DYRK1A (3 products) 

     
    antibodies-online peptides for DYRK1A

    DYRK1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DYRK1A
    R&D Systems Antibodies for DYRK1A
    Cell Signaling Technology (CST) Antibodies for DYRK1A 
    OriGene Antibodies for DYRK1A
    OriGene Custom Antibody Services for DYRK1A
    Novus Biologicals DYRK1A Antibodies
    Abcam antibodies for DYRK1A
    Cloud-Clone Corp. Antibodies for DYRK1A
    ThermoFisher Antibodies for DYRK1A
    antibodies-online antibodies for DYRK1A (78 products) 

    DYRK1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DYRK1A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DYRK1A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DYRK1A
    Cloud-Clone Corp. CLIAs for DYRK1A
    Search eBioscience for ELISAs for DYRK1A 
    antibodies-online kits for DYRK1A (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
    Dyrk1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13627

    ProtoNet protein and cluster: Q13627

    UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
    Domain: The polyhistidine repeats act as targeting signals to nuclear speckles (PubMed:19266028)
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with DYRK1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYR1A_HUMAN, Q13627
    Function: May play a role in a signaling pathway regulating nuclear functions of cell proliferation.
    Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2,
    FOXO1 and SIRT1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by RANBP9

         Genatlas biochemistry entry for DYRK1A:
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1,Drosophila minibrain homolog Dres27,mouse homolog
    ubiquitously expressed at low levels in embryo,expressed in adult central nervous system
    -cortex,hippocampus,striatum and spinal cord) located in the Down syndrome critical region (DCR),involved in
    post-embryonic neurogenesis,putatively overexpressed in Down syndrome and involved in the learning defect and in
    hypotonia

         Enzyme Numbers (IUBMB): EC 2.7.122 EC 2.7.12.11

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8769099
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004712protein serine/threonine/tyrosine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ISS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA9748265
         
    Find genes that share ontologies with DYRK1A           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for DYRK1A:
     Decreased 12E8 tau but not tot  Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i 
     Increased mitotic index 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dyrk1a):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  liver/biliary system 
     mortality/aging  nervous system 

    Find genes that share phenotypes with DYRK1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dyrk1atm1Mla for DYRK1A

       genOway: Develop your customized and physiologically relevant rodent model for DYRK1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target DYRK1A:
    hsa-mir-99b-5p (MIRT044178), hsa-mir-192-5p (MIRT026227), hsa-mir-324-5p (MIRT043199), hsa-mir-92a-3p (MIRT049774), hsa-mir-215-5p (MIRT024657), hsa-mir-335-5p (MIRT017031), hsa-mir-148a-3p (MIRT026006)

    Block miRNA regulation of human, mouse, rat DYRK1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DYRK1A (see all 172):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-409-5p hsa-miR-298 hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DYRK1A
    Predesigned siRNA for gene silencing in human, mouse, rat DYRK1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DYRK1A

    Clone
    Products:
         
    OriGene clones in human, mouse for DYRK1A (see all 25)
    OriGene ORF clones in mouse, rat for DYRK1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DYRK1A (NM_001396)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYRK1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1A
    Addgene plasmids for DYRK1A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DYRK1A
    Browse ESI BIO Cell Lines and PureStem Progenitors for DYRK1A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1A

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12303) for DYRK1A 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DYR1A_HUMAN, Q13627: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck ISS--
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with DYRK1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DYRK1A About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    3Translation Insulin regulation of translation
    Translation Regulation activity of EIF20.47
    4Hedgehog Signaling Pathway
    Hedgehog Signaling Pathway0.32
    5Notch Signaling Pathways
    Notch Signaling Pathways


    Find genes that share SuperPaths with DYRK1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DYRK1A
        Notch Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for DYRK1A
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for DYRK1A
        Translation Regulation of EIF2 activity

    1 BioSystems Pathway for DYRK1A
        Hedgehog Signaling Pathway

    1 Reactome Pathway for DYRK1A
        G0 and Early G1


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYRK1A
    Interactions:

        GeneGlobe Interaction Network for DYRK1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYRK1A (Q136271, 2, 3 ENSP000003819324) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation ISS--
    GO:0007399nervous system development TAS8769099
    GO:0007623circadian rhythm ISS--
    GO:0018105peptidyl-serine phosphorylation IEA--

    Find genes that share ontologies with DYRK1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYRK1A (DYR1A)

    2 HMDB Compounds for DYRK1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for DYRK1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide-- --target--10592235

    10 Novoseek inferred chemical compound relationships for DYRK1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 63.7 6 15780591 (1), 11828259 (1), 14990717 (1), 19016842 (1) (see all 6)
    serine 52.2 4 11828259 (1), 14990717 (1), 19801542 (1), 19796173 (1)
    tyrosine 49.9 47 17536841 (6), 19796173 (3), 12604362 (2), 19016842 (2) (see all 17)
    glycogen 40.2 1 11311121 (1)
    phosphotyrosine 21.3 10 17536841 (2)
    leucine 11.7 2 8975710 (1), 9070862 (1)
    arginine 8.37 4 10644696 (1), 14623875 (1), 11755526 (1)
    proline 3.33 2 11311121 (1)
    histidine 0 1 17536841 (1)
    alanine 0 2 10644696 (1), 12604362 (1)



    Find genes that share compounds with DYRK1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DYRK1A gene (5 alternative transcripts): 
    NM_001396.3  NM_101395.2  NM_130436.2  NM_130438.2  NM_130437.2  

    Unigene Cluster for DYRK1A:

    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
    Hs.368240  [show with all ESTs]
    Unigene Representative Sequence: NM_130436
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608928 ENST00000462274 ENST00000338785(uc002ywg.1 uc002ywh.1 uc002ywi.3 uc002ywk.3 uc002ywm.3 uc011aei.2)
    ENST00000455097(uc010gno.1) ENST00000426672 ENST00000339659(uc002ywj.3)
    ENST00000398960 ENST00000498351 ENST00000398956 ENST00000321219 ENST00000451934
    ENST00000455387
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DYRK1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DYRK1A (see all 172):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-409-5p hsa-miR-298 hsa-miR-642b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DYRK1A
    Predesigned siRNA for gene silencing in human, mouse, rat DYRK1A
    Clone
    Products:
         
    OriGene clones in human, mouse for DYRK1A (see all 25)
    OriGene ORF clones in mouse, rat for DYRK1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DYRK1A (NM_001396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYRK1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1A
    Addgene plasmids for DYRK1A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DYRK1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYRK1A
      QuantiTect SYBR Green Assays in human, mouse, rat DYRK1A
      QuantiFast Probe-based Assays in human, mouse, rat DYRK1A
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12303) for DYRK1A 

    Additional mRNA sequence: 

    AB015282.1 AB015283.1 AB015284.1 AF108830.1 AJ001870.1 AJ001871.1 AK301752.1 BC030515.1 
    BC045802.1 BC065184.1 D85759.1 D86550.1 U52373.1 U58496.1 Z25423.1 

    9 DOTS entries:

    DT.97806866  DT.100791954  DT.449194  DT.92438592  DT.75101238  DT.121141919  DT.121141927  DT.92044861 
    DT.92438591 

    Selected AceView cDNA sequences (see all 287):

    AI424886 AI391600 BE790930 BM722758 CD557221 AA932861 W93238 AB015282 
    F12144 AA729988 AU119258 AA887600 NM_101395 NM_001396 AA933085 AI394170 
    NM_130436 AA704601 BI495555 AU280024 AL047452 BM553514 AL046742 BI753541 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1A (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                                -                                                                                       
    SP2:                                                        -                                                     -         
    SP3:                                                                                                              -         
    SP4:                          -     -                       -                                                               
    SP5:                          -     -     -                 -                                                               


    ECgene alternative splicing isoforms for DYRK1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DYRK1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTCTTATG
    DYRK1A Expression
    About this image


    DYRK1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Liver Bud
    DYRK1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYRK1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368240

    UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
    Tissue specificity: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney

        Custom PCR Arrays for DYRK1A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DYRK1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYRK1A
    QuantiTect SYBR Green Assays in human, mouse, rat DYRK1A
    QuantiFast Probe-based Assays in human, mouse, rat DYRK1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DYRK1A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dyrk1a1 , 5 dual-specificity tyrosine-(Y)-phosphorylation regulated more1, 5 93.93(n)1
    99.21(a)1
      16 (55.30 cM)5
    135481  NM_001113389.11  NP_001106860.11 
     945700105 
    chicken
    (Gallus gallus)
    Aves DYRK1A1 dual-specificity tyrosine-(Y)-phosphorylation regulated more 88.15(n)
    96.42(a)
      395233  NM_204550.1  NP_989881.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYRK1A6
    dual-specificity tyrosine-(Y)-phosphorylation regu...
    98(a)
    1 ↔ 1
    3(140718560-140857690)
    African clawed frog
    (Xenopus laevis)
    Amphibia dyrk1a-prov2 dual-specificity tyrosine-(Y)-phosphorylation regulated more 79.47(n)    BC044104.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dyrk1aa1 dual-specificity tyrosine-(Y)-phosphorylation regulated more 72.44(n)
    82.83(a)
      100005019  NM_001080689.1  NP_001074158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mnb3 circadian rhythm protein
    serine/threonine kinase
    82(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mbk-13 serine/threonine kinase (2 domains) 70(a)   X(14855249-14860148)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAK16
    Serine-threonine protein kinase; component of a gl...
    21(a)
    1 → many
    X(147967-150390) YJL141C
    rice
    (Oryza sativa)
    Liliopsida Os.143132 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 78.14(n)    AK068489.1 


    ENSEMBL Gene Tree for DYRK1A (if available)
    TreeFam Gene Tree for DYRK1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DYRK1A gene
    DYRK22  DYRK32  HIPK12  ENSG000002729212  DYRK42  HIPK32  HIPK42  HIPK22  
    DYRK1B2  
    14 SIMAP similar genes for DYRK1A using alignment to 4 protein entries:     DYR1A_HUMAN (see all proteins):
    MNB/DYRK    DYRK1B    CDK7    DYRK4    MOK    DYRK2
    DYRK3    HIPK1    SRPK3    MAPK14    MARK4    HIPK2
    CDK4    ULK1

    Find genes that share paralogs with DYRK1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DYRK1A (see all 3142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739039281,2
    C,F--24213563(+) GGGTAG/AGGAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1929097601,2
    --24213590(+) GCCAGA/GATATT 1 -- us2k10--------
    rs1428076571,2
    --24213736(+) TTCCGA/CTGGAG 1 -- us2k10--------
    rs732039361,2
    C,F--24213773(+) GGAGAG/AGTTGG 1 -- us2k11Minor allele frequency- A:0.09NA 120
    rs1479533871,2
    C--24215031(+) GGGCG-/GGAGGAGG 1 -- us2k10--------
    rs1840995061,2
    --24215122(+) TGGTTA/GGTTTT 1 -- us2k10--------
    rs2007784671,2
    --24215123(+) GTTGG-/TTTTTT 1 -- us2k10--------
    rs1394829901,2
    --24215236(+) CTGCTA/GTCGCT 1 -- us2k10--------
    rs1880918081,2
    --24215340(+) TGCTGC/TTGCTG 1 -- us2k10--------
    rs1809059691,2
    --24215620(+) GCCGGC/TAGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYRK1A (38738092 - 38889753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYRK1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1001034CNV Deletion20482838
    nsv834096CNV Loss17160897

    Human Gene Mutation Database (HGMD): DYRK1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYRK1A
    DNA2.0 Custom Variant and Variant Library Synthesis for DYRK1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600855   
    OMIM disorders: 614104  
    UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
  • Mental retardation, autosomal dominant 7 (MRD7) [MIM:614104]: A disease characterized by primary
    microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features,
    including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is
    characterized by significantly below average general intellectual functioning associated with impairments in
    adaptive behavior and manifested during the developmental period. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 3 diseases for DYRK1A:    
    About MalaCards
    mental retardation, autosomal dominant 7    down syndrome    mental retardation, autosomal dominant 10

    2 diseases from the University of Copenhagen DISEASES database for DYRK1A:
    Down syndrome     Intellectual disability

    Find genes that share disorders with DYRK1A           About GenesLikeMe

    6 Novoseek inferred disease relationships for DYRK1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 86 67 12618396 (4), 15694837 (3), 10812554 (3), 12814361 (2) (see all 33)
    mental retardation 71.7 8 15906374 (1), 16959772 (1), 9918863 (1), 11877424 (1) (see all 8)
    trisomy 45.4 7 11555628 (1), 16554754 (1), 19242551 (1)
    memory impairment 41.3 4 17696169 (1), 17536841 (1)
    alzheimers disease 37.6 8 19995442 (2), 18696092 (1), 17135279 (1), 19665384 (1) (see all 5)
    neuropathology 36.6 1 12618396 (1)

    Genetic Association Database (GAD): DYRK1A
    Human Genome Epidemiology (HuGE) Navigator: DYRK1A (2 documents)

    Export disorders for DYRK1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DYRK1A gene, integrated from 10 sources (see all 184):
    (articles sorted by number of sources associating them with DYRK1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'. (PubMed id 8975710)1, 2, 9 Song W.J....Kurnit D.W. (Genomics 1996)
    2. DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort. (PubMed id 19995442)1, 4, 9 VA!zquez-Higuera J.L....Combarros O. (BMC Med. Genet. 2009)
    3. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. (PubMed id 10329007)1, 2, 9 Guimera J.... Pritchard M.A. (Genomics 1999)
    4. Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2. (PubMed id 9284911)1, 3, 9 Guimera J....Estivill X. (Cytogenet. Cell Genet. 1997)
    5. Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21. (PubMed id 8769099)1, 2, 9 Shindoh N....Shimizu N. (Biochem. Biophys. Res. Commun. 1996)
    6. A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. (PubMed id 8872470)1, 2, 9 Guimera J.... Pritchard M.A. (Hum. Mol. Genet. 1996)
    7. Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. (PubMed id 9037601)1, 2, 9 Ohira M....Ohki M. (Genome Res. 1997)
    8. Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages. (PubMed id 21364930)1, 4 Bol S.M....van 't Wout A.B. (PLoS ONE 2011)
    9. Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly. (PubMed id 21294719)1, 2 van Bon B.W.... de Vries B.B. (Clin. Genet. 2011)
    10. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PubMed id 20694148)1, 4 Zabaneh D. and Balding D.J. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1859 HGNC: 3091 AceView: DYRK1A Ensembl:ENSG00000157540 euGenes: HUgn1859
    ECgene: DYRK1A H-InvDB: DYRK1A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DYRK1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DYRK1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DYRK1A gene:
    Search GeneIP for patents involving DYRK1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of DYRK1A
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant DYRK1A Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for DYRK1A (DYRK1A)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DYRK1A   OriGene RNAi products in human, mouse, rat for DYRK1A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DYRK1A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DYRK1A  
     OriGene qSTAR qPCR primer pairs in human, mouse for DYRK1A   OriGene Purified Protein for DYRK1A  
     OriGene ORF clones in mouse, rat for DYRK1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DYRK1A   OriGene Custom Protein Services for DYRK1A  

     
     
     Block miRNA regulation of human, mouse, rat DYRK1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DYRK1A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYRK1A Predesigned siRNA for gene silencing in human, mouse, rat DYRK1A
     QuantiFast Probe-based Assays in human, mouse, rat DYRK1A QuantiTect SYBR Green Assays in human, mouse, rat DYRK1A
     Custom PCR Arrays for DYRK1A Search Chromatin IP Primers for DYRK1A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYRK1A  GeneGlobe Interaction Network for DYRK1A
     Regulatory tfbs in DYRK1A promoter
     GenScript Custom Purified and Recombinant Proteins Services for DYRK1A GenScript cDNA clones with any tag delivered in your preferred vector for DYRK1A
     GenScript Custom Assay Services for DYRK1A GenScript Custom overexpressing Cell Line Services for DYRK1A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for DYRK1A 

     Search Tocris compounds for DYRK1A (DYR1A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DYRK1A antibodies
     DYRK1A proteins
     DYRK1A lysates
     Antibodies for DYRK1A
     See all of Abcam's Antibodies, Kits and Proteins for DYRK1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DYRK1A
     Antibodies for DYRK1A
     ELISAs for DYRK1A
     CLIAs for DYRK1A



     Browse ESI BIO Cell Lines and PureStem Progenitors for DYRK1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYRK1A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DYRK1A
     SwitchGear Promoter luciferase reporter plasmids for DYRK1A
     ThermoFisher Antibodies for DYRK1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYRK1A
     Browse compounds at ApexBio
     Addgene plasmids for DYRK1A
      Search eBioscience for proteins for DYRK1A
      Search eBioscience for elisas for DYRK1A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DYRK1A
     antibodies-online antibodies for DYRK1A (78 products)
     antibodies-online kits for DYRK1A (12 products)
     antibodies-online peptides for DYRK1A
     antibodies-online proteins for DYRK1A (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DYRK1A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4