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DYRK1A Gene

protein-coding GIFtS: 65

GC21P037661

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: DYRK1, DYRK, MNBH)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
DYRK ^², ³
DYRK1 ^²
EC 2.7.12.1 ^³
HP86 ^², ³
MNB ^², ³, ⁵
MNBH ^², ³, ⁵
OTTHUMP00000109090 ^²
hMNB ^³

Descriptions
Dual specificity YAK1-related kinase ^², ³
MNB/DYRK protein kinase ^²
Protein kinase minibrain homolog ^², ³
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A ^²
dual-specificity tyrosine-Y-phosphorylation regulated kinase, EC 2.7.1 ⁹
mnb protein kinase homolog hp86 ^²
serine/threonine kinase MNB ^²
serine/threonine-specific protein kinase ^²

External Ids
HGNC: 3091¹
Entrez Gene: 1859²
UniProtKB: Q13627³
Ensembl: ENSG00000157540⁷

Search outside databases for aliases for DYRK1A gene

Previous GC identifers: GC21P035317 GC21P037659 GC21P037712 GC21P037660

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DYRK1A:

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK)

family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a

leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its

autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a

signaling pathway regulating cell proliferation and may be involved in brain development. This

gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the

Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene

for learning defects associated with Down syndrome. Alternative splicing of this gene generates

several transcript variants differing from each other either in the 5' UTR or in the 3'

coding region. These variants encode at least five different isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627

Function: May play a role in a signaling pathway regulating nuclear functions of cell

proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in

exogenous substrates

Gene Wiki entry for DYRK1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13 Ensembl cytogenetic band: 21q22.13 HGNC cytogenetic band: 21q22.13
Nature(405: 311-319) cytogenetic band: 21q22.13

DYRK1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P037661:	GeneLoc	Nature:405,311-319
Start:	37,661,729 bp from pter	24,367,732 bp from centromere
End:	37,809,550 bp from pter	24,464,002 bp from centromere
Size:	147,822 bases	96,271 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	D86550
genomic clones:	pT1091 to pS165

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627 (See protein sequence)

Recommended Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Size: 763 amino acids; 85584 Da

Subunit: Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9

Subcellular location: Nucleus speckle

Developmental stage: Expressed in the developing central nervous system

PDB structures from and Proteopedia :

2VX3 (3D)

Secondary accessions: O60769 Q92582 Q92810 Q9UNM5

Alternative splicing: 5 isoforms: Q13627-1 Q13627-2 Q13627-3 Q13627-4 Q13627-5 (Additional isoforms seem to exist)

Post-translational modifications:

Autophosphorylated on tyrosine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001387.2 NP_567824.1 NP_569120.1 NP_569121.1 NP_569122.1

ENSEMBL proteins:

ENSP00000381923 ENSP00000381932 ENSP00000342690 ENSP00000319032 ENSP00000381929 ENSP00000340373

Human Recombinant Proteins

	Invitrogen human recombinant proteins for DYRK1A
	Millipore Purified and/or Recombinant DYRK1A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DYRK1A)
	Human Recombinant Proteins from Abnova (DYRK1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0016607	nuclear speck	ISS	--

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Antibodies for DYRK1A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DYRK1A
	R&D Systems Antibodies for DYRK1A
	Cell Signaling Technology (CST) Antibodies for DYRK1A
	Antibodies from Abcam (DYRK1A), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for DYRK1A

Assays for DYRK1A:

	Invitrogen Assays for DYRK1A
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13627

ProtoNet protein and cluster: Q13627

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DYRK1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DYRK1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_101395

Applied Biosystems Silencer® siRNAs for DYRK1A

Sigma-Aldrich siRNA and siRNA Panels for DYRK1A

Sigma-Aldrich shRNA Panels and shRNA for DYRK1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001396
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001396
untagged cDNA clones in CMV expression vector (see all 5): NM_001396

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001396

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627

Function: May play a role in a signaling pathway regulating nuclear functions of cell

proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in

exogenous substrates

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Inhibited by RANBP9

Enzyme Number (IUBMB): EC 2.7.12.1

Genatlas biochemistry entry for DYRK1A:

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1,Drosophila minibrain homolog

Dres27,mouse homolog ubiquitously expressed at low levels in embryo,expressed in adult central

nervous system -cortex,hippocampus,striatum and spinal cord) located in the Down syndrome critical

region (DCR),involved in post-embryonic neurogenesis,putatively overexpressed in Down syndrome and

involved in the learning defect and in hypotonia

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dyrk1a):

	craniofacial	embryogenesis	growth/size	lethality-postnatal
lethality-prenatal/perinatal	liver/biliary system	nervous system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	ISS	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IDA	9748265
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for DYRK1A (Your Favorite Gene powered by Ingenuity)

Nicotinate and Nicotinamide Metabolism
Sonic Hedgehog Signaling
Inositol Phosphate Metabolism

GeneDecks DYRK1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DYRK1A

5/44 Interacting proteins for DYRK1A (ENSP00000340373³ Q13627^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946¹	STRING (score=.712) EBI-1053621, EBI-359815
YWHAE	P62258²	MINT-51046 MINT-51048 MINT-51047
SFN	P31947²	MINT-3975419
YWHAG	P61981²	MINT-50850
WDR68	ENSP00000308344³	STRING (score=.976)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007399	nervous system development	TAS	8769099
GO:0018108	peptidyl-tyrosine phosphorylation	ISS	--
GO:0046777	protein amino acid autophosphorylation	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for DYRK1A:

Inhibitor

Browse Tocris compounds for DYRK1A
7 Novoseek chemical compound relationships for DYRK1A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	58.03	4	15780591 (1), 11828259 (1), 14990717 (1), 19016842 (1)
tyrosine	44.04	34	17536841 (6), 12604362 (2), 19016842 (2), 8975710 (1) (see all 12)
glycogen	39.78	1	11311121 (1)
phosphotyrosine	24.35	10	17536841 (2)
leucine	15.16	2	8975710 (1), 9070862 (1)
proline	7.20	2	11311121 (1)
histidine	3.75	1	17536841 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DYRK1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DYRK1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_101395

Sigma-Aldrich siRNA and siRNA Panels for DYRK1A

Sigma-Aldrich shRNA Panels and shRNA for DYRK1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001396 NM_101395 NM_130436 NM_130437 NM_130438

REFSEQ mRNAs for DYRK1A gene (5 alternative transcripts):

NM_001396.3 NM_101395.2 NM_130436.2 NM_130437.2 NM_130438.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001396 NM_101395 NM_130436 NM_130437 NM_130438

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001396
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001396
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001396

Additional cDNA sequence:

AB015282.1 AB015283.1 AB015284.1 AF108830.1 AJ001870.1 AK301752.1 BC030515.1 BC045802.1

BC065184.1 D85759.1 D86550.1 U52373.1 U58496.1 Z25423.1

10 DOTS entries:

DT.97806866 DT.100791954 DT.449194 DT.92438592 DT.121141919 DT.121141927 DT.92044861 DT.91741448

DT.92438591 DT.75101238

24/287 AceView cDNA sequences (see all 287 ):

Z45133 AI076027 AI627548 BE790930 BG165287 AI478511 BM553514 AU280024

BI753541 CA389685 AL046760 NM_001396 AI149373 AA687255 AB015283 AA831486

CN479966 AA866036 AL046742 AI174919 BF794263 BC065184 NM_101395 AB015282

highest scoring ESTs for DYRK1A:

D86550 U52373 U58496 AA279906 AA306050 AA322447 AA331181 AA337593 AA342261 AA497079

Unigene Clusters for DYRK1A:

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

Hs.368240 [show with all ESTs], Hs.719269 [show with all ESTs]

Unigene Representative Sequences: XM_001721653, NM_130436

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DYRK1A (see all 6 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14
SP1:											-
SP2:																			-																		-
SP3:																																					-
SP4:									-		-								-
SP5:									-		-		-						-

About this scheme

ECgene alternative splicing isoforms for DYRK1A

6 Ensembl transcripts including schematic representations:

ENST00000398950 ENST00000398960 ENST00000338785 ENST00000321219 ENST00000398956 ENST00000339659

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DYRK1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DYRK1A

¹ / ² / ³

10 probe-sets matching DYRK1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36947_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.12	0.16	U58496	1.00	1.00	1.00	1
827_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.08	0.15	U52373	1.00	1.00	1.00	1
36946_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.01	D86550	1.00	1.00	1.00	1
1512_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.99	D86550	1.00	1.00	1.00	1
211541_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U52373	1.00	1.00	1.00	1
211079_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	Z25423	0.40	1.00	0.76	1
209033_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D86550	1.00	1.00	1.00	1
211541_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211079_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209033_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGGTGTTTT

SOURCE GeneReport for Unigene clusters: Hs.368240 Hs.719269
Expression variation in blood from EXPOLDB for DYRK1A
UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627
Tissue specificity: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal
kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DYRK1A gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DYRK1A¹	--	dual-specificity tyrosine-(Y)-phosphorylation regulated more	96.19(n) 99.54(a)	487755 XM_844487.1 XP_849580.1
chimpanzee (Pan troglodytes)	DYRK1A¹	--	dual-specificity tyrosine-(Y)-phosphorylation regulated more	99.65(n) 100(a)	458545 XM_514894.2 XP_514894.2
cow (Bos taurus)	DYRK1A¹	--	dual-specificity tyrosine-(Y)-phosphorylation regulated more	95.54(n) 99.61(a)	532989 XM_612233.3 XP_612233.2
rat (Rattus norvegicus)	Dyrk1a¹	--	dual-specificity tyrosine-(Y)-phosphorylation regulated more	94.28(n) 99.61(a)	25255 NM_012791.1 NP_036923.1
mouse (Mus musculus)	Dyrk1a^{1, 5}	16 (68.30 cM)⁵	dual-specificity tyrosine-(Y)-phosphorylation regulated more^{1, 5}	93.93(n)¹ 99.21(a)¹	13548¹ NM_007890.1¹ NP_031916.1¹ AK009788⁵ AK047845⁵ (see all 26)

About this table Species with no ortholog for DYRK1A

ENSEMBL Gene Tree for DYRK1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DYRK1A gene

DYRK1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

2 NCBI SNPs in DYRK1A are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs73903928^1,2	--	37659806(+)	`GGGTAA/GGGAGA`	1	--	ng5¹		0	--	--	--	--
--	rs73203936^1,2	--	37660016(+)	`GGAGAA/GGTTGG`	1	--	ng5¹		0	--	--	--	--

About this table
The following additional 279 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs2835721	rs8126815	rs2835773	rs9974713	rs2835771	rs1049802	rs1049780
rs2835767	rs1049787	rs11911833	rs12481879	rs2835754	rs9984646	rs2154545
rs17814764	rs2211840	rs2835734	rs9980200	rs16995148	rs2835740	rs11701469
rs2835706	rs2835765	rs2898316	rs12626319	rs9981259	rs2835723	rs1049769
rs8133103	rs11702573	rs1049755	rs1049763	rs13047462	rs9975364	rs2835764
rs17814746	rs7364101	rs2835737	rs2835727	rs1137600	rs2835726	rs2298328
rs1049777	rs17458669	rs13048394	rs2835738	rs1049783	rs17229459	rs17193211
rs16995075	rs16995170	rs1049754	rs11700779	rs1049782	rs9975239	rs2835742
rs4817865	rs17229325	rs11088394	rs2835732	rs1049762	rs17814651	rs2835728
rs12151982	rs8133143	rs28678082	rs2835735	rs9981091	rs2835731	rs7276747
rs9979445	rs11910554	rs1049773	rs11701810	rs1049764	rs1803439	rs2835749
rs13052269	rs6517413	rs13050792	rs11701483	rs16995167	rs2835752	rs11701386
rs8129641	rs8132789	rs2835768	rs7276643	rs2835753	rs2835766	rs2298330
rs11700804	rs11702088	rs7281206	rs2236685	rs2835778	rs2835725	rs1049765
rs17229339	rs11088391	rs12626399	rs2835715	rs34896662	rs13047129	rs2835718
rs2835776	rs11701982	rs2835747	rs1049791	rs28692714	rs1049779	rs28702969
rs28529284	rs8128582	rs2835756	rs12482409	rs1049770	rs16995173	rs8132000
rs11702026	rs13049514	rs2835741	rs2835777	rs2298329	rs9980596	rs11701206
rs2068173	rs11700427	rs8131330	rs1049771	rs2835748	rs9974493	rs10483037
rs7278611	rs7282670	rs8129473	rs7720	rs11701543	rs2835736	rs2236688
rs6517420	rs17814693	rs724671	rs1475887	rs1010265	rs2835745	rs2835774
rs11702689	rs2211839	rs55987540	rs2236687	rs16995172	rs9974126	rs1060578
rs2026264	rs2835772	rs8133809	rs13052173	rs2835763	rs11088392	rs2236686
rs2835711	rs2835714	rs16995099	rs7281326	rs28630928	rs2835724	rs9976328
rs2835779	rs2248244	rs2835750	rs2835733	rs7283089	rs2186338	rs1049757
rs724672	rs11701862	rs7281260	rs2835744	rs9975651	rs7277020	rs7277921
rs2835730	rs2835761	rs13049697	rs11701874	rs2835769	rs8132976	rs8126722
rs11702765	rs9982990	rs11700462	rs9975652	rs11702096	rs2835759	rs12483205
rs2835729	rs13048401	rs1049761	rs11911681	rs2251085	rs4817864	rs17229402
rs9982117	rs13049853	rs11702209	rs11908916	rs10470178	rs11088393	rs1049768
rs2860151	rs1130751	rs2835704	rs2835719	rs2835707	rs2835708	rs8132830
rs36060563	rs1024294	rs1049766	rs9975193	rs8126696	rs9977549	rs16995239
rs2835705	rs928764	rs1049756	rs11911857	rs34651026	rs4817863	rs2186339
rs9975083	rs16995107	rs12483014	rs16997966	rs16995110	rs1049788	rs2835751
rs2835762	rs6517414	rs9974163	rs1049781	rs2835720	rs9977098	rs34155819
rs4817866	rs2211838	rs13046025	rs762143	rs11700902	rs2835770	rs28594606
rs2835712	rs2154543	rs2835722	rs11701678	rs2835775	rs8132256	rs13046383
rs16995134	rs11701900	rs17814633	rs1049758	rs9977979	rs12481981	rs9978910
rs2835760	rs928763	rs11908990	rs11088390	rs2835709	rs2835755	rs11702000
rs11702865	rs2835739	rs2835713	rs13050046	rs9979074	rs2245343

HapMap Linkage Disequilibrium images for DYRK1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600855

UniProtKB/Swiss-Prot: DYR1A_HUMAN, Q13627

Overexpressed 1.5-fold in fetal Down syndrome brain

6 Novoseek disease relationships for DYRK1A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	84.97	55	12618396 (4), 15694837 (3), 10812554 (3), 12814361 (2) (see all 26)
mental retardation	72.41	7	15906374 (1), 16959772 (1), 9918863 (1), 11877424 (1) (see all 7)
trisomy	48.25	7	11555628 (1), 16554754 (1), 19242551 (1)
memory impairment	44.90	4	17696169 (1), 17536841 (1)
neuropathology	40.26	1	12618396 (1)
alzheimers disease	26.93	3	18696092 (1), 16242644 (1), 17135279 (1)

About this table

Human Gene Mutation Database: DYRK1A

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/117 PubMed articles for DYRK1A gene (see all 117 ):

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'. (PubMed id 8975710)^{1, 3, 4} Song W.J....Kurnit D.W. (1996)
Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. (PubMed id 10329007)^{1, 3, 4} Guimera J.... Pritchard M.A. (1999)
Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2. (PubMed id 9284911)^{1, 2, 3} Guimera J....Estivill X. (1997)
Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21. (PubMed id 8769099)^{1, 3, 4} Shindoh N....Shimizu N. (1996)
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. (PubMed id 8872470)^{1, 3, 4} Guimera J.... Pritchard M.A. (1996)
Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. (PubMed id 9037601)^{1, 3, 4} Ohira M....Ohki M. (1997)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran- binding protein M. (PubMed id 14500717)^{3, 4} Zou Y.... Friedman E. (2003)
Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. (PubMed id 9503011)^{3, 4} Dahmane N.... Delabar J.-M. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1859	HGNC: 3091	AceView: DYRK1A	Ensembl:ENSG00000157540	euGenes: HUgn1859
ECgene: DYRK1A	H-InvDB: DYRK1A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for DYRK1A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DYRK1A:

TaqMan ® Gene Expression Assays

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DYRK1A Gene

protein-coding GIFtS: 65

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DYRK1A Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor DYRK1A

Summariesfor DYRK1A

Genomic Locationfor DYRK1A

Proteinsfor DYRK1A

Protein Domains/Familiesfor DYRK1A

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Publicationsfor DYRK1A

Search for DYRK1A

Genome Databases showing DYRK1A

Other Databases showing DYRK1A

Specialized Databases showing DYRK1A

Licensable Technologiesfor DYRK1A

Servicesfor DYRK1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DYRK1A

Summaries
for DYRK1A

Genomic Location
for DYRK1A

Proteins
for DYRK1A

Protein Domains/
Families
for DYRK1A

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for DYRK1A

Pathways & Interactions
for DYRK1A

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for DYRK1A

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for DYRK1A

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for DYRK1A

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