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Aliases for DYNLT3 Gene

Aliases for DYNLT3 Gene

  • Dynein Light Chain Tctex-Type 3 2 3
  • Dynein, Light Chain, Tctex-Type 3 3 5
  • Protein 91/23 3 4
  • TCTE1L 3 4
  • T-Complex-Associated-Testis-Expressed 1-Like 2
  • T-Complex-Associated Testis-Expressed 1-Like 4
  • TCTEX1L 3
  • TCTE1XL 4
  • RP3 3

External Ids for DYNLT3 Gene

Previous HGNC Symbols for DYNLT3 Gene

  • TCTE1L

Previous GeneCards Identifiers for DYNLT3 Gene

  • GC0XM037455
  • GC0XM037580
  • GC0XM037696
  • GC0XM035443

Summaries for DYNLT3 Gene

Entrez Gene Summary for DYNLT3 Gene

  • This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

GeneCards Summary for DYNLT3 Gene

DYNLT3 (Dynein Light Chain Tctex-Type 3) is a Protein Coding gene. Diseases associated with DYNLT3 include Retinitis Pigmentosa. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include identical protein binding and motor activity. An important paralog of this gene is DYNLT1.

UniProtKB/Swiss-Prot for DYNLT3 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Gene Wiki entry for DYNLT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLT3 Gene

Genomics for DYNLT3 Gene

Regulatory Elements for DYNLT3 Gene

Enhancers for DYNLT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DYNLT3 on UCSC Golden Path with GeneCards custom track

Promoters for DYNLT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DYNLT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DYNLT3 Gene

Chromosome:
X
Start:
37,836,757 bp from pter
End:
37,847,637 bp from pter
Size:
10,881 bases
Orientation:
Minus strand

Genomic View for DYNLT3 Gene

Genes around DYNLT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLT3 Gene

Proteins for DYNLT3 Gene

  • Protein details for DYNLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51808-DYLT3_HUMAN
    Recommended name:
    Dynein light chain Tctex-type 3
    Protein Accession:
    P51808
    Secondary Accessions:
    • Q6ICS3

    Protein attributes for DYNLT3 Gene

    Size:
    116 amino acids
    Molecular mass:
    13062 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.

neXtProt entry for DYNLT3 Gene

Proteomics data for DYNLT3 Gene at MOPED

Post-translational modifications for DYNLT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNLT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DYNLT3 Gene

Domains & Families for DYNLT3 Gene

Gene Families for DYNLT3 Gene

Protein Domains for DYNLT3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P51808

UniProtKB/Swiss-Prot:

DYLT3_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with DYNLT3: view

Function for DYNLT3 Gene

Molecular function for DYNLT3 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).
genes like me logo Genes that share phenotypes with DYNLT3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNLT3 Gene

Localization for DYNLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLT3 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLT3 Gene COMPARTMENTS Subcellular localization image for DYNLT3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005868 cytoplasmic dynein complex IEA,IDA 11425878
genes like me logo Genes that share ontologies with DYNLT3: view

Pathways & Interactions for DYNLT3 Gene

genes like me logo Genes that share pathways with DYNLT3: view

Pathways by source for DYNLT3 Gene

Gene Ontology (GO) - Biological Process for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with DYNLT3: view

No data available for SIGNOR curated interactions for DYNLT3 Gene

Drugs & Compounds for DYNLT3 Gene

(1) Drugs for DYNLT3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DYNLT3: view

Transcripts for DYNLT3 Gene

mRNA/cDNA for DYNLT3 Gene

Unigene Clusters for DYNLT3 Gene

Dynein, light chain, Tctex-type 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT3 Gene

No ASD Table

Relevant External Links for DYNLT3 Gene

GeneLoc Exon Structure for
DYNLT3
ECgene alternative splicing isoforms for
DYNLT3

Expression for DYNLT3 Gene

mRNA expression in normal human tissues for DYNLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DYNLT3 Gene

This gene is overexpressed in Colon (10.4), Retina (8.1), and Islet of Langerhans (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLT3 Gene



SOURCE GeneReport for Unigene cluster for DYNLT3 Gene Hs.446392

genes like me logo Genes that share expression patterns with DYNLT3: view

Protein tissue co-expression partners for DYNLT3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DYNLT3 Gene

Orthologs for DYNLT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DYNLT3 35
  • 91.95 (n)
  • 93.97 (a)
DYNLT3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLT3 35
  • 93.1 (n)
  • 96.55 (a)
DYNLT3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlt3 35
  • 86.49 (n)
  • 90.52 (a)
Dynlt3 16
Dynlt3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYNLT3 35
  • 99.43 (n)
  • 100 (a)
DYNLT3 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynlt3 35
  • 82.47 (n)
  • 86.21 (a)
oppossum
(Monodelphis domestica)
Mammalia DYNLT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLT3 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNLT3 35
  • 77.59 (n)
  • 79.31 (a)
DYNLT3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLT3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlt3 35
  • 68.71 (n)
  • 64.04 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.4843 35
dynlt3 35
  • 69.57 (n)
  • 68.7 (a)
dynlt3 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1114 35
worm
(Caenorhabditis elegans)
Secernentea dylt-1 36
  • 29 (a)
OneToOne
Species with no ortholog for DYNLT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNLT3 Gene

ENSEMBL:
Gene Tree for DYNLT3 (if available)
TreeFam:
Gene Tree for DYNLT3 (if available)

Paralogs for DYNLT3 Gene

Paralogs for DYNLT3 Gene

(5) SIMAP similar genes for DYNLT3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DYNLT3 Gene

genes like me logo Genes that share paralogs with DYNLT3: view

Variants for DYNLT3 Gene

Sequence variations from dbSNP and Humsavar for DYNLT3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747769342 -- 37,842,557(+) CCATA(C/G)TGCTT intron-variant
rs747819558 -- 37,840,438(+) TAATA(C/T)TCAGT utr-variant-3-prime
rs748003258 -- 37,840,054(+) CTATA(C/T)TATTA utr-variant-3-prime
rs748163046 -- 37,840,752(+) CATAT(-/ACAC)ACACA intron-variant
rs748686635 -- 37,841,752(+) CAAGT(A/G)AACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLT3 Gene

Variant ID Type Subtype PubMed ID
nsv515194 CNV Loss 21397061

Variation tolerance for DYNLT3 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DYNLT3 Gene

Disorders for DYNLT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYNLT3 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DYNLT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNLT3
genes like me logo Genes that share disorders with DYNLT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLT3 Gene

Publications for DYNLT3 Gene

  1. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. (PMID: 8004092) Roux A.-F. … Musarella M. (Hum. Mol. Genet. 1994) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for DYNLT3 Gene

Sources for DYNLT3 Gene

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