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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYNLT3 Gene

protein-coding   GIFtS: 56
GCID: GC0XM037696

dynein, light chain, Tctex-type 3

(Previous name: t-complex-associated-testis-expressed 1-like )
(Previous symbol: TCTE1L)
 Explore 3 diseases affiliated with
DYNLT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DYNLT3    

Aliases
for DYNLT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dynein, Light Chain, Tctex-Type 31 2     RP32
TCTE1L1 2 3 5     Dynein Light Chain Tctex-Type 32
TCTEX1L1 2     TCTE1XL3
Protein 91/232 3     T-Complex-Associated Testis-Expressed 1-Like3
T-Complex-Associated-Testis-Expressed 1-Like1     

External Ids:    HGNC: 116941   Entrez Gene: 69902   Ensembl: ENSG000001651697   OMIM: 3003025   UniProtKB: P518083   

Export aliases for DYNLT3 gene to outside databases

Previous GC identifers: GC0XM037455 GC0XM037580 GC0XM035443


Summaries
for DYNLT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DYNLT3:
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light
chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to
specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein
as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.(provided by RefSeq, Mar
2010)

UniProtKB/Swiss-Prot: DYLT3_HUMAN, P51808
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic
dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity)

Gene Wiki entry for DYNLT3


Genomic Views
for DYNLT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYNLT3 gene promoter:
         C/EBPbeta   AP-1   Lmo2   POU6F1 (c2)   C/EBPalpha   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYNLT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYNLT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp21

DYNLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLT3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM037696:  view genomic region     (about GC identifiers)

Start:
 37,696,010 bp from pter      End:
 37,706,890 bp from pter
Size:
 10,881 bases      Orientation:
 minus strand

Proteins
for DYNLT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DYLT3_HUMAN, P51808 (See protein sequence)
Recommended Name: Dynein light chain Tctex-type 3  
Size: 116 amino acids; 13062 Da
Subunit: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of
non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains
(LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as
a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind
directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein
IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3.
Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA
Subcellular location: Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3
at kinetochores specifically during prometaphase
Caution: Was originally (PubMed:8004092) thought to be a candidate for RP3

Explore the universe of human proteins at neXtProt for DYNLT3: NX_P51808

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51808

    • DYNLT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006511.1  
    ENSEMBL proteins: 
     ENSP00000367844   ENSP00000367841   ENSP00000402695  

    Human Recombinant Protein Products: 
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    Novus Biologicals DYNLT3 Lysate
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    ProSpec Recombinant Protein for DYNLT3
    Uscn Proteins for DYNLT3

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA17289665
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005868cytoplasmic dynein complex IDA11425878


    DYNLT3 for ontologies           About GeneDecksing



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    Uscn Antibodies for DYNLT3
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    Uscn ELISAs and CLIAs for DYNLT3

    Protein Domains /
    Families
    for DYNLT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DYNLT3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005334 Tctex

    Graphical View of Domain Structure for InterPro Entry P51808

    ProtoNet protein and cluster: P51808

    1 Blocks protein family: IPB005334 Tctex-1 family

    UniProtKB/Swiss-Prot: DYLT3_HUMAN, P51808
    Similarity: Belongs to the dynein light chain Tctex-type family


    Function
    for DYNLT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DYLT3_HUMAN, P51808
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic
    dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
    Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYNLT3
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate DYNLT3 (see all 27):
    hsa-miR-125a-5p hsa-miR-448 hsa-miR-520e hsa-miR-302d hsa-miR-25 hsa-miR-302e hsa-miR-3142 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DYNLT3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DYNLT3 (see all 7)
    OriGene shRNA RFP: DYNLT3
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--


    DYNLT3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DYNLT3:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for DYNLT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    2Regulation of degradation of wt-CFTR
    		Regulation of degradation of deltaF508 CFTR in CF0.59
    3Cytoskeleton remodeling Neurofilaments
    		Cytoplasmic microtubules0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for DYNLT3
        Cell cycle Spindle assembly and chromosome separation
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DYNLT3
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF



    DYNLT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNLT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for DYNLT3 (P518082, 3 ENSP000003678414) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNC1I2Q134092, 3, ENSP000003803084MINT-66315 I2D: score=5 STRING: ENSP00000380308
    TESCQ96BS22, 3, ENSP000003763284MINT-67428 I2D: score=4 STRING: ENSP00000376328
    CD5P061273, ENSP000003426814I2D: score=1 STRING: ENSP00000342681
    DYNC1I1O145763, ENSP000003201304I2D: score=1 STRING: ENSP00000320130
    BUB3O436843, ENSP000003578584I2D: score=2 STRING: ENSP00000357858
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007067mitosis IEA--
    GO:0007346regulation of mitotic cell cycle ISS--
    GO:0051301cell division IEA--


    DYNLT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DYNLT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DYNLT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYNLT3
    1 Novoseek chemical compound relationship for DYNLT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 58.8 2 11581184 (1), 12011183 (1)

    Search CenterWatch for drugs/clinical trials and news about DYNLT3 / DYLT3 

    Transcripts
    for DYNLT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DYNLT3 gene: 
    NM_006520.2  

    Unigene Cluster for DYNLT3:

    Dynein, light chain, Tctex-type 3
    Hs.446392  [show with all ESTs]
    Unigene Representative Sequence: NM_006520
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378581 ENST00000378578(uc004dds.3) ENST00000432389

    miRNA
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    hsa-miR-125a-5p hsa-miR-448 hsa-miR-520e hsa-miR-302d hsa-miR-25 hsa-miR-302e hsa-miR-3142 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DYNLT3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLT3
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    Additional cDNA sequence: 

    AK311851.1 BC000968.2 CR450320.1 CR542213.1 U02556.1 

    4 DOTS entries:

    DT.215099  DT.100786638  DT.100786643  DT.91797628 

    24/207 AceView cDNA sequences (see all 207):

    AI673828 AA384649 H11107 BM023362 CB216313 CR450320 BI838609 BP343409 
    AA385480 BU688171 CK820754 AI167535 BU190049 AV729307 CR622725 T17272 
    AI910360 CB105131 BM739420 BM968373 AA583341 BQ771757 BC000968 CB125998 

    GeneLoc Exon Structure


    Expression
    for DYNLT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYNLT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGACTTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DYNLT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See DYNLT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYNLT3

    SOURCE GeneReport for Unigene cluster: Hs.446392
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLT3

    Orthologs
    for DYNLT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DYNLT3 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dynlt31 , 5 dynein light chain Tctex-type 31, 5 86.49(n)1
    90.52(a)1    		   X (4.47 cM)5
    671171  NM_025975.51  NP_080251.31 
     96542675 
    chicken
    (Gallus gallus)    		 Aves DYNLT31 dynein, light chain, Tctex-type 3 77.59(n)
    79.31(a)    		   418580  XM_416782.3  XP_416782.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DYNLT36
    		 --
    		 72(a)
    		 1 ↔ 1
    		 3(132252463-132259694)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.48432 Danio rerio clone RK112A4H12 t-complex-associated-testis-expressed more 71.22(n)    AY398423.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dylt-16
    dylt-36
    		 Protein DYLT-3
    		 39(a)
    17(a)
    		 possible ortholog
    possible ortholog
    		 I(7300060-7300913)
    II(8181334-8182257)


    ENSEMBL Gene Tree for DYNLT3 (if available)
    TreeFam Gene Tree for DYNLT3 (if available) 

    Paralogs
    for DYNLT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYNLT3 gene
    DYNLT12  
    6 SIMAP similar genes for DYNLT3 using alignment to 3 protein entries:     DYLT3_HUMAN (see all proteins):
    TCTE1L    FAM3A    FANCA    DYNLT1    CNOT2    ATL2

    DYNLT3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DYNLT3
    PGOHUM00000247453 PGOHUM00000240901


    Genomic Variants
    for DYNLT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 NCBI SNPs in DYNLT3 are shown (see all 176)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1929430441,2
    		--37697749(+) CTTGTA/TTTGTT 1 -- ds50010--------
    rs1398975211,2
    		--37698063(+) TAACTA/GTTAAA 1 -- ds50010--------
    rs1850875111,2
    		--37698397(+) AATATC/GAAACA 1 -- ut310--------
    rs128491,2
    		C,F,A,H,--37698422(-) TATTCT/ATGTAG 1 -- ut319Minor allele frequency- A:0.30MN NS EA NA CSA 794
    rs1880275741,2
    		--37698459(+) CTAAGC/GTTATT 1 -- ut310--------
    rs1917559441,2
    		--37698471(+) CTCTCC/TAAAAT 1 -- ut310--------
    rs455607381,2
    		C,--37698488(+) AGTTAC/TGGTTC 1 -- ut310--------
    rs1839705331,2
    		--37698494(+) GGTTCC/TGCTCT 1 -- ut310--------
    rs1138572661,2
    		C,--37698495(+) GTTCCA/GCTCTC 1 -- ut311Minor allele frequency- G:0.00CSA 1
    rs1882034071,2
    		--37698633(+) ATTACA/TTTTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DYNLT3 (37696010 - 37706890 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DYNLT3: --
    Locus Specific Mutation Databases (LSDB): DYNLT3

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    Disorders / Diseases
    for DYNLT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DYNLT3 for disorders           About GeneDecksing

    OMIM gene information: 300302    OMIM disorders: --

    3 diseases for DYNLT3:    About MalaCards
    ornithine carbamoyltransferase deficiency    herpes simplex    malaria

    1 disease from the University of Copenhagen DISEASES database for DYNLT3:
    Ornithine carbamoyltransferase deficiency

    1 Novoseek disease relationship for DYNLT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 66.1 1 11581184 (1)


    Export disorders for DYNLT3 gene to outside databases

    Publications
    for DYNLT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYNLT3 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with DYNLT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. (PubMed id 8004092)1, 2, 3 Roux A.-F.... Musarella M. (1994)
    2. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. (PubMed id 17289665)1, 2 Lo K.W....Pfister K.K. (2007)
    3. Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. (PubMed id 16079286)1, 2 Yeh T.-Y.... Sung C.-H. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Identification of the dynein light chains required for human papillomavirus infection. (PubMed id 21166973)1 Schneider M.A.... Lambert C. (2011)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. Identification of binding domains in the herpes simpl ex virus type 1 small capsid protein pUL35 (VP26). (PubMed id 20668116)1 Apcarian A....Diefenbach R.J. (2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for DYNLT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DYNLT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6990 HGNC: 11694 AceView: TCTE1L Ensembl:ENSG00000165169 euGenes: HUgn6990
    ECgene: DYNLT3 H-InvDB: DYNLT3

    Other Databases showing DYNLT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DYNLT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYNLT3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DYNLT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DYNLT3 gene:
    Search GeneIP for patents involving DYNLT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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