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Aliases for DYNLT3 Gene

Aliases for DYNLT3 Gene

  • Dynein, Light Chain, Tctex-Type 3 2 3
  • TCTE1L 3 4 6
  • Protein 91/23 3 4
  • T-Complex-Associated-Testis-Expressed 1-Like 2
  • T-Complex-Associated Testis-Expressed 1-Like 4
  • Dynein Light Chain Tctex-Type 3 3
  • TCTEX1L 3
  • TCTE1XL 4
  • RP3 3

External Ids for DYNLT3 Gene

Previous HGNC Symbols for DYNLT3 Gene

  • TCTE1L

Previous GeneCards Identifiers for DYNLT3 Gene

  • GC0XM037455
  • GC0XM037580
  • GC0XM037696
  • GC0XM035443

Summaries for DYNLT3 Gene

Entrez Gene Summary for DYNLT3 Gene

  • This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]

GeneCards Summary for DYNLT3 Gene

DYNLT3 (Dynein, Light Chain, Tctex-Type 3) is a Protein Coding gene. Diseases associated with DYNLT3 include retinitis pigmentosa. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include identical protein binding and motor activity. An important paralog of this gene is DYNLT1.

UniProtKB/Swiss-Prot for DYNLT3 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Gene Wiki entry for DYNLT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLT3 Gene

Genomics for DYNLT3 Gene

Regulatory Elements for DYNLT3 Gene

Genomic Location for DYNLT3 Gene

Start:
37,836,757 bp from pter
End:
37,847,637 bp from pter
Size:
10,881 bases
Orientation:
Minus strand

Genomic View for DYNLT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNLT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLT3 Gene

Proteins for DYNLT3 Gene

  • Protein details for DYNLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51808-DYLT3_HUMAN
    Recommended name:
    Dynein light chain Tctex-type 3
    Protein Accession:
    P51808
    Secondary Accessions:
    • Q6ICS3

    Protein attributes for DYNLT3 Gene

    Size:
    116 amino acids
    Molecular mass:
    13062 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.

neXtProt entry for DYNLT3 Gene

Proteomics data for DYNLT3 Gene at MOPED

Post-translational modifications for DYNLT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNLT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DYNLT3 Gene

Domains for DYNLT3 Gene

Gene Families for DYNLT3 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNLT3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DYNLT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51808

UniProtKB/Swiss-Prot:

DYLT3_HUMAN :
  • P51808
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with DYNLT3: view

Function for DYNLT3 Gene

Molecular function for DYNLT3 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).

Gene Ontology (GO) - Molecular Function for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with DYNLT3: view

Phenotypes for DYNLT3 Gene

GenomeRNAi human phenotypes for DYNLT3:
genes like me logo Genes that share phenotypes with DYNLT3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DYNLT3 Gene

Localization for DYNLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLT3 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLT3 Gene COMPARTMENTS Subcellular localization image for DYNLT3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 4
cytosol 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA 17289665
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005868 cytoplasmic dynein complex IDA 11425878
genes like me logo Genes that share ontologies with DYNLT3: view

Pathways for DYNLT3 Gene

genes like me logo Genes that share pathways with DYNLT3: view

Pathways by source for DYNLT3 Gene

Gene Ontology (GO) - Biological Process for DYNLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007346 regulation of mitotic cell cycle ISS --
GO:0008152 metabolic process IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with DYNLT3: view

Compounds for DYNLT3 Gene

(1) Novoseek inferred chemical compound relationships for DYNLT3 Gene

Compound -log(P) Hits PubMed IDs
ornithine 58.8 2
genes like me logo Genes that share compounds with DYNLT3: view

Transcripts for DYNLT3 Gene

mRNA/cDNA for DYNLT3 Gene

Unigene Clusters for DYNLT3 Gene

Dynein, light chain, Tctex-type 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT3 Gene

No ASD Table

Relevant External Links for DYNLT3 Gene

GeneLoc Exon Structure for
DYNLT3
ECgene alternative splicing isoforms for
DYNLT3

Expression for DYNLT3 Gene

mRNA expression in normal human tissues for DYNLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLT3 Gene

SOURCE GeneReport for Unigene cluster for DYNLT3 Gene Hs.446392

genes like me logo Genes that share expressions with DYNLT3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DYNLT3 Gene

Orthologs for DYNLT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLT3 35
  • 99.43 (n)
  • 100 (a)
DYNLT3 36
  • 68 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNLT3 35
  • 91.95 (n)
  • 93.97 (a)
DYNLT3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLT3 35
  • 93.1 (n)
  • 96.55 (a)
DYNLT3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlt3 35
  • 86.49 (n)
  • 90.52 (a)
Dynlt3 16
Dynlt3 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNLT3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLT3 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynlt3 35
  • 82.47 (n)
  • 86.21 (a)
chicken
(Gallus gallus)
Aves DYNLT3 35
  • 77.59 (n)
  • 79.31 (a)
DYNLT3 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLT3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlt3 35
  • 68.71 (n)
  • 64.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1114 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4843 35
dynlt3 35
  • 69.57 (n)
  • 68.7 (a)
dynlt3 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dylt-1 36
  • 29 (a)
OneToOne
Species with no ortholog for DYNLT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNLT3 Gene

ENSEMBL:
Gene Tree for DYNLT3 (if available)
TreeFam:
Gene Tree for DYNLT3 (if available)

Paralogs for DYNLT3 Gene

Paralogs for DYNLT3 Gene

Selected SIMAP similar genes for DYNLT3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DYNLT3 Gene

genes like me logo Genes that share paralogs with DYNLT3: view

Variants for DYNLT3 Gene

Sequence variations from dbSNP and Humsavar for DYNLT3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs11771 -- 37,841,795(-) AAAGC(C/T)TATAA reference, synonymous-codon
rs12849 -- 37,839,169(-) TATTC(A/T)TGTAG utr-variant-3-prime
rs720525 -- 37,841,224(+) ACAAA(C/G)AAAAA intron-variant
rs1012907 -- 37,845,144(-) GGAAA(C/T)TGGGA intron-variant
rs1049514 -- 37,840,090(-) AGTGG(A/G)AAGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DYNLT3 Gene

Variant ID Type Subtype PubMed ID
nsv515194 CNV Loss 21397061

Relevant External Links for DYNLT3 Gene

HapMap Linkage Disequilibrium report
DYNLT3
Locus Specific Mutation Databases (LSDB)
DYNLT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLT3 Gene

Disorders for DYNLT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DYNLT3 Gene including...

Search for DYNLT3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DYNLT3 Gene

(1) Novoseek inferred disease relationships for DYNLT3 Gene

Disease -log(P) Hits PubMed IDs
retinitis pigmentosa 66.1 1
genes like me logo Genes that share disorders with DYNLT3: view

No data available for UniProtKB/Swiss-Prot for DYNLT3 Gene

Publications for DYNLT3 Gene

  1. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. (PMID: 8004092) Roux A.-F. … Musarella M. (Hum. Mol. Genet. 1994) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. (PMID: 16079286) Yeh T.-Y. … Sung C.-H. (J. Cell Sci. 2005) 3 4
  4. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. (PMID: 17289665) Lo K.W. … Pfister K.K. (J. Biol. Chem. 2007) 3 4
  5. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. (PMID: 17676955) O'Rourke S.M. … Bowerman B. (PLoS Genet. 2007) 3

Products for DYNLT3 Gene

Sources for DYNLT3 Gene

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