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Aliases for DYNLT1 Gene

Aliases for DYNLT1 Gene

  • Dynein Light Chain Tctex-Type 1 2 3 5
  • T-Complex-Associated-Testis-Expressed 1-Like 1 2 3
  • T-Complex Testis-Specific Protein 1 Homolog 3 4
  • Tctex-1 3 4
  • TCTEL1 3 4
  • Protein CW-1 4
  • TCTEX1 4
  • CW-1 3

External Ids for DYNLT1 Gene

Previous HGNC Symbols for DYNLT1 Gene

  • TCTEL1

Previous GeneCards Identifiers for DYNLT1 Gene

  • GC06M159028
  • GC06M158977
  • GC06M159057
  • GC06M156528

Summaries for DYNLT1 Gene

Entrez Gene Summary for DYNLT1 Gene

  • This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for DYNLT1 Gene

DYNLT1 (Dynein Light Chain Tctex-Type 1) is a Protein Coding gene. Diseases associated with DYNLT1 include Pulmonary Hypertension and Glaucomatocyclitic Crisis. Among its related pathways are Innate Immune System and Lissencephaly gene (LIS1) in neuronal migration and development. Gene Ontology (GO) annotations related to this gene include identical protein binding and motor activity. An important paralog of this gene is DYNLT3.

UniProtKB/Swiss-Prot for DYNLT1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.

  • Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274).

  • (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site.

Gene Wiki entry for DYNLT1 Gene

Additional gene information for DYNLT1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLT1 Gene

Genomics for DYNLT1 Gene

GeneHancer (GH) Regulatory Elements for DYNLT1 Gene

Promoters and enhancers for DYNLT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I158641 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 560.8 +0.2 181 5.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 DYNLT1 SYTL3 TMEM181 GTF2H5 PIR53252
GH06I158847 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.3 -208.3 -208336 11.2 CLOCK MLX YBX1 FEZF1 SLC30A9 E2F8 ZNF548 MCM3 SP3 MEF2D WTAP DYNLT1 EZR SYTL3 LOC442272 RNU6-293P TCP1 TATDN2P2 MRPL18 TAGAP
GH06I158559 Enhancer 1.5 Ensembl ENCODE dbSUPER 18.7 +84.0 83995 3.3 HDGF FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF766 E2F8 PIR46336 PIR47640 PIR42837 TMEM181 DYNLT1 SYTL3
GH06I158648 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -7.6 -7554 8.2 HDGF PKNOX1 SMAD1 MLX IRF4 ZNF48 SLC30A9 ZNF143 ATF7 FOS SYTL3 DYNLT1 TATDN2P2 TAGAP LOC442272 RNU6-293P TMEM181 AMZ2P2
GH06I158703 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12 -61.3 -61309 5.7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 E2F8 SYTL3 DYNLT1 LOC442272 RNU6-293P TMEM181 TULP4 AMZ2P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DYNLT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DYNLT1 gene promoter:

Genomic Locations for DYNLT1 Gene

Genomic Locations for DYNLT1 Gene
chr6:158,636,474-158,644,786
(GRCh38/hg38)
Size:
8,313 bases
Orientation:
Minus strand
chr6:159,057,506-159,065,804
(GRCh37/hg19)

Genomic View for DYNLT1 Gene

Genes around DYNLT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLT1 Gene

Proteins for DYNLT1 Gene

  • Protein details for DYNLT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63172-DYLT1_HUMAN
    Recommended name:
    Dynein light chain Tctex-type 1
    Protein Accession:
    P63172
    Secondary Accessions:
    • Q15763
    • Q5VTU4

    Protein attributes for DYNLT1 Gene

    Size:
    113 amino acids
    Molecular mass:
    12452 Da
    Quaternary structure:
    • Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma (By similarity). Interacts with ACVR2B and ARHGEF2. Interacts with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry.

    Three dimensional structures from OCA and Proteopedia for DYNLT1 Gene

neXtProt entry for DYNLT1 Gene

Post-translational modifications for DYNLT1 Gene

  • Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).
  • Ubiquitination at posLast=5656

Other Protein References for DYNLT1 Gene

No data available for DME Specific Peptides for DYNLT1 Gene

Domains & Families for DYNLT1 Gene

Gene Families for DYNLT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DYNLT1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P63172

UniProtKB/Swiss-Prot:

DYLT1_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with DYNLT1: view

Function for DYNLT1 Gene

Molecular function for DYNLT1 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.
UniProtKB/Swiss-Prot Function:
Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site.

Phenotypes From GWAS Catalog for DYNLT1 Gene

Gene Ontology (GO) - Molecular Function for DYNLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 10644691
GO:0008022 protein C-terminus binding IEA --
GO:0042802 identical protein binding IPI 17965411
genes like me logo Genes that share ontologies with DYNLT1: view

Phenotypes for DYNLT1 Gene

genes like me logo Genes that share phenotypes with DYNLT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNLT1 Gene

Localization for DYNLT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLT1 Gene

Golgi apparatus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to mitotic spindles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLT1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 3
cytosol 3
golgi apparatus 3
mitochondrion 2
plasma membrane 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DYNLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with DYNLT1: view

Pathways & Interactions for DYNLT1 Gene

genes like me logo Genes that share pathways with DYNLT1: view

Gene Ontology (GO) - Biological Process for DYNLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation ISS --
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
GO:0007399 nervous system development IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway ISS --
genes like me logo Genes that share ontologies with DYNLT1: view

No data available for SIGNOR curated interactions for DYNLT1 Gene

Drugs & Compounds for DYNLT1 Gene

No Compound Related Data Available

Transcripts for DYNLT1 Gene

Unigene Clusters for DYNLT1 Gene

Dynein, light chain, Tctex-type 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for DYNLT1 Gene

GeneLoc Exon Structure for
DYNLT1
ECgene alternative splicing isoforms for
DYNLT1

Expression for DYNLT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYNLT1 Gene

Protein differential expression in normal tissues from HIPED for DYNLT1 Gene

This gene is overexpressed in Fetal Brain (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYNLT1 Gene



Protein tissue co-expression partners for DYNLT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYNLT1 Gene:

DYNLT1

SOURCE GeneReport for Unigene cluster for DYNLT1 Gene:

Hs.445999

mRNA Expression by UniProt/SwissProt for DYNLT1 Gene:

P63172-DYLT1_HUMAN
Tissue specificity: Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).

Evidence on tissue expression from TISSUES for DYNLT1 Gene

  • Nervous system(4.6)
  • Muscle(4.4)
  • Lung(3.2)
  • Skin(2.9)
  • Blood(2.7)
genes like me logo Genes that share expression patterns with DYNLT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLT1 Gene

Orthologs for DYNLT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLT1 33 34
  • 100 (n)
mouse
(Mus musculus)
Mammalia Dynlt1f 16 34
  • 94 (a)
Dynlt1a 34
  • 94 (a)
OneToMany
Dynlt1c 34
  • 94 (a)
OneToMany
Dynlt1b 33 34
  • 88.5 (n)
oppossum
(Monodelphis domestica)
Mammalia DYNLT1 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLT1 33 34
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Dynlt1 33
  • 89.97 (n)
cow
(Bos Taurus)
Mammalia DYNLT1 33 34
  • 89.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLT1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNLT1 33 34
  • 82.7 (n)
lizard
(Anolis carolinensis)
Reptilia DYNLT1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlt1 33
  • 78.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25778 33
zebrafish
(Danio rerio)
Actinopterygii dynlt1 33 34
  • 71.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001229 33
  • 67.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dlc90F 33 34
  • 67.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3016 34
  • 81 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14340 33
Species where no ortholog for DYNLT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYNLT1 Gene

ENSEMBL:
Gene Tree for DYNLT1 (if available)
TreeFam:
Gene Tree for DYNLT1 (if available)

Paralogs for DYNLT1 Gene

Paralogs for DYNLT1 Gene

(2) SIMAP similar genes for DYNLT1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DYNLT1 Gene

genes like me logo Genes that share paralogs with DYNLT1: view

Variants for DYNLT1 Gene

Sequence variations from dbSNP and Humsavar for DYNLT1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000160813 -- 158,638,695(-) C/T intron_variant
rs1000349597 -- 158,640,287(-) C/T intron_variant
rs1000377034 -- 158,644,326(-) C/T intron_variant
rs1000420457 -- 158,646,254(-) C/T upstream_transcript_variant
rs1000497962 -- 158,637,409(-) A/G intron_variant

Variation tolerance for DYNLT1 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DYNLT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DYNLT1 Gene

Disorders for DYNLT1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DYNLT1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pulmonary hypertension
  • primary pulmonary hypertension
glaucomatocyclitic crisis
  • terrien-viel syndrome
palindromic rheumatism
  • hench's syndrome
behcet syndrome
  • behcet disease; bd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DYNLT1

genes like me logo Genes that share disorders with DYNLT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLT1 Gene

Publications for DYNLT1 Gene

  1. Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. (PMID: 15194795) Ohka S … Nomoto A (Journal of virology 2004) 3 4 22 58
  2. Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. (PMID: 14583445) Machado RD … Trembath RC (Human molecular genetics 2003) 3 4 22 58
  3. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. (PMID: 8646886) Watanabe TK … Hirai Y (Cytogenetics and cell genetics 1996) 2 3 4 58
  4. Molecular Basis for the Protein Recognition Specificity of the Dynein Light Chain DYNLT1/Tctex1: CHARACTERIZATION OF THE INTERACTION WITH ACTIVIN RECEPTOR IIB. (PMID: 27502274) Merino-Gracia J … Rodríguez-Crespo I (The Journal of biological chemistry 2016) 3 4 58
  5. Identification of the dynein light chains required for human papillomavirus infection. (PMID: 21166973) Schneider MA … Lambert C (Cellular microbiology 2011) 3 4 58

Products for DYNLT1 Gene

Sources for DYNLT1 Gene

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