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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DYNLT1 Gene

protein-coding GIFtS: 52
GCID: GC06M159057

dynein, light chain, Tctex-type 1

(Previous name: t-complex-associated-testis-expressed 1-like 1 )
(Previous symbol: TCTEL1)

Explore 10 diseases affiliated with
DYNLT1 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dynein, Light Chain, Tctex-Type 1¹ ²		Dynein Light Chain Tctex-Type 1²
TCTEL1¹ ² ³ ⁵		Tctex-1¹
T-Complex-Associated-Testis-Expressed 1-Like 1¹ ²		TCTEX-1³
T-Complex Testis-Specific Protein 1 Homolog² ³		TCTEX1³
CW-1²		Protein CW-1³

External Ids:	HGNC: 11697¹	Entrez Gene: 6993²	Ensembl: ENSG00000146425⁷	OMIM: 601554⁵	UniProtKB: P63172³

Export aliases for DYNLT1 gene to outside databases

Previous GC identifers: GC06M159028 GC06M158977 GC06M156528

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DYNLT1:

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes.

Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory

polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005 (PubMed

15992542)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172

Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are

thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic

dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized

epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly

site. May also be a accessory component of axonemal dynein

Function: Plays a role in neuronal morhpogenesis; the function is independent of cytoplasmic dynein and seems to be

coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be

regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of

heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in

regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably

by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity)

Gene Wiki entry for DYNLT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DYNLT1 gene promoter:
Elk-1 Nkx2-5 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) CUTL1 LCR-F1 POU3F2 MEF-2A FAC1 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYNLT1 promoter sequence

Search SABiosciences Chromatin IP Primers for DYNLT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2-q25.3 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25.2-q25.3

DYNLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLT1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M159057: view genomic region (about GC identifiers)

Start:	159,057,506 bp from pter	End:	159,065,804 bp from pter
Size:	8,299 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172 (See protein sequence)

Recommended Name: Dynein light chain Tctex-type 1

Size: 113 amino acids; 12452 Da

Subunit: Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a

number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light

chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer

serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs

bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with

dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts

with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with

GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction

diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the

interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma (By similarity). Interacts

with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry

Subcellular location: Golgi apparatus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton, spindle (By

similarity). Note=Localizes to mitotic spindles (By similarity)

Secondary accessions: Q15763 Q5VTU4

Explore the universe of human proteins at neXtProt for DYNLT1: NX_P63172

Post-translational modifications:

Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms

of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation status is

proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo

release (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P63172

DYNLT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006510.1

ENSEMBL proteins:

ENSP00000356055 ENSP00000356056 ENSP00000356052

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DYNLT1
	Uscn Proteins for DYNLT1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--
GO:0005819	spindle	IEA	--
GO:0005868	cytoplasmic dynein complex	ISS	--
GO:0005874	microtubule	IEA	--

DYNLT1 for ontologies About GeneDecksing

DYNLT1 Antibody Products:

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	GenScript Custom Assay Services for DYNLT1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DYNLT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DYNLT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR005334 Tctex

Graphical View of Domain Structure for InterPro Entry P63172

ProtoNet protein and cluster: P63172

1 Blocks protein family: IPB005334 Tctex-1 family

UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172

Similarity: Belongs to the dynein light chain Tctex-type family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172

Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are

thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic

dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized

epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly

site. May also be a accessory component of axonemal dynein

Function: Plays a role in neuronal morhpogenesis; the function is independent of cytoplasmic dynein and seems to be

coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be

regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of

heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in

regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably

by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: DYNLT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYNLT1
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate DYNLT1 (see all 15):
		hsa-miR-374b* hsa-miR-142-5p hsa-miR-3688-3p hsa-miR-29c hsa-miR-29a hsa-miR-3617 hsa-miR-3647-3p hsa-miR-659

		SwitchGear 3'UTR luciferase reporter plasmid: DYNLT1 3' UTR sequence

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for DYNLT1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	IEA	--
GO:0005515	protein binding	IPI	10644691
GO:0042802	identical protein binding	IPI	17965411

DYNLT1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Lissencephaly gene (LIS1) in neuronal migration and development

Lissencephaly gene (LIS1) in neuronal migration and development

1.00

Neurotrophic factor-mediated Trk receptor signaling

Neurotrophic factor-mediated Trk receptor signaling

1.00

Regulation of degradation of wt-CFTR

Regulation of degradation of deltaF508 CFTR in CF

0.59

Cytoskeleton remodeling Neurofilaments

Cytoplasmic microtubules

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DYNLT1

	Cell cycle Spindle assembly and chromosome separation
	Cytoplasmic microtubules

2 GeneGo (Thomson Reuters) Pathways for DYNLT1

	Cell cycle Spindle assembly and chromosome separation
	Regulation of degradation of deltaF508 CFTR in CF

2 BioSystems Pathways for DYNLT1

	Neurotrophic factor-mediated Trk receptor signaling
	Lissencephaly gene (LIS1) in neuronal migration and development

DYNLT1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DYNLT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/86 Interacting proteins for DYNLT1 (P63172^{1, 3} ENSP00000356056⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 86)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPB9	Q9BQS6¹^,³, ENSP00000347178⁴	EBI-1176455,EBI-1176448 I2D: score=2 STRING: ENSP00000347178
NME1-NME2	P22392³	I2D: score=5
NME2	P22392³	I2D: score=5
DOC2A	Q14183³, ENSP00000340017⁴	I2D: score=1 STRING: ENSP00000340017
SOD1	P00441³, ENSP00000270142⁴	I2D: score=1 STRING: ENSP00000270142

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000132	establishment of mitotic spindle orientation	ISS	--
GO:0007067	mitosis	IEA	--
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	ISS	--
GO:0019060	intracellular transport of viral proteins in host cell	IMP	18647839
GO:0032314	regulation of Rac GTPase activity	--	--

DYNLT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DYNLT1
Search CenterWatch for drugs/clinical trials and news about DYNLT1 / DYLT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DYNLT1 gene:

NM_006519.2

Unigene Cluster for DYNLT1:

Dynein, light chain, Tctex-type 1

Hs.445999 [show with all ESTs]

Unigene Representative Sequence: AK026669

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367088 ENST00000367089(uc003qrn.2) ENST00000367085

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYNLT1
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		hsa-miR-374b* hsa-miR-142-5p hsa-miR-3688-3p hsa-miR-29c hsa-miR-29a hsa-miR-3617 hsa-miR-3647-3p hsa-miR-659

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLT1

Additional cDNA sequence:

AK026669.1 AK315601.1 BC029412.1 BC105588.1 CR456931.1 D50663.1 EU862237.1 U56255.1

14 DOTS entries:

DT.446239 DT.91712992 DT.320052 DT.92439422 DT.95221196 DT.121311728 DT.100824618 DT.121311801

DT.91655389 DT.100824616 DT.40110972 DT.91678998 DT.95221269 DT.92439405

24/420 AceView cDNA sequences (see all 420):

BU902675 AA329809 CB269610 AI984152 CB118733 AA142898 AA187770 AF052495

BX096970 AA748161 BM314199 AI186060 BU685942 BU608340 AI275672 AA099901

BM979828 CA449176 U56255 AA044202 BG750548 BU631343 AI143771 CB164687

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:					-						-		-
SP2:					-		-				-		-
SP3:											-		-		-
SP4:					-
SP5:

ECgene alternative splicing isoforms for DYNLT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DYNLT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTCAGTGA

About this image
See DYNLT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYNLT1

SOURCE GeneReport for Unigene cluster: Hs.445999

UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172

Tissue specificity: Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary,

ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level)

SABiosciences Custom PCR Arrays for DYNLT1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DYNLT1 gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DYNLT1¹	dynein, light chain, Tctex-type 1	82.89(n) 90.27(a)		421660 XM_419699.3 XP_419699.1
lizard (Anolis carolinensis)	Reptilia	DYNLT1⁶	--	88(a)	1 ↔ 1	1(212775208-212784402)
African clawed frog (Xenopus laevis)	Amphibia	Xl.25778²	Xenopus laevis transcribed sequence with moderate similarity more	80(n)		BJ033560.1
zebrafish (Danio rerio)	Actinopterygii	si:dkey-148f10.4¹	si:dkey-148f10.4	69.97(n) 72.07(a)		100318879 XM_002665184.1 XP_002665230.1
fruit fly (Drosophila melanogaster)	Insecta	Dlc90F¹	Dynein light chain 90F	67.61(n) 72.64(a)		42199 NM_058008.3 NP_477356.1
worm (Caenorhabditis elegans)	Secernentea	dylt-1⁶ dylt-3⁶	Protein DYLT-3	36(a) 17(a)	possible ortholog possible ortholog	I(7300060-7300913) II(8181334-8182257)

ENSEMBL Gene Tree for DYNLT1 (if available)
TreeFam Gene Tree for DYNLT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DYNLT1 gene

DYNLT3²

3 SIMAP similar genes for DYNLT1 using alignment to 3 protein entries: DYLT1_HUMAN (see all proteins):

TCTE1L DYNLT3 TCTEX1D2

DYNLT1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for DYNLT1
PGOHUM00000237223 PGOHUM00000245851

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62432934^1,2	C,	--	159057049(+)	`CATGGA/GGAGGA`	1	--	int¹		2		NA	122
rs142197395^1,2	C,	--	159057081(+)	`TTGGT-/TGTGTAT`	1	--	int¹		0	--	--	--	--
rs13216422^1,2	C,F,H,	--	159057085(+)	`GTTGTA/GTATAT`	1	--	int¹		12		NS EA	1978
rs150797490^1,2		--	159057174(+)	`CAGTGA/GCGGGA`	1	--	int¹		0	--	--	--	--
rs113846700^1,2		--	159057202(+)	`GGCTCG/ACTACA`	1	--	int¹		1		CSA	2
rs71551136^1,2	C,	--	159057273(+)	`CAGGCA/GCCCGC`	1	--	int¹		2		NA	4
rs185196513^1,2		--	159057301(+)	`TTTTGG/TTATTT`	1	--	int¹		0	--	--	--	--
rs111952125^1,2	C,	--	159057320(+)	`GACGGA/GGTTTC`	1	--	int¹		2		NA CSA	3
rs188516174^1,2		--	159057340(+)	`GACAGA/GATGGT`	1	--	int¹		0	--	--	--	--
rs73016239^1,2	C,F,	--	159057419(+)	`ACTGCG/ACCTGG`	1	--	int¹		4		NA CSA	126

HapMap Linkage Disequilibrium report for DYNLT1 (159057506 - 159065804 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DYNLT1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DYNLT1 for disorders           About GeneDecksing

OMIM gene information: 601554    OMIM disorders: --

10 diseases for DYNLT1:    About MalaCards

glaucomatocyclitic crisis primary pulmonary hypertension pulmonary hypertension herpes simplex

leiomyosarcoma hypertension leiomyoma malaria

prostatitis neuronitis

Export disorders for DYNLT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DYNLT1 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with DYNLT1)

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Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. (PubMed id 8646886)^{1, 2, 3} Watanabe T.K.... Hirai Y. (1996)
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. (PubMed id 14583445)^{1, 2, 9} Machado R.D....Trembath R.C. (2003)
Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. (PubMed id 15194795)^{1, 2, 9} Ohka S....Nomoto A. (2004)
Identification of the dynein light chains required for human papillomavirus infection. (PubMed id 21166973)^{1, 2} Schneider M.A.... Lambert C. (2011)
D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein. (PubMed id 18647839)^{1, 2} Vlach J....Ruml T. (2008)
Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. (PubMed id 17965411)^{1, 2} Lo K.W.... Pfister K.K. (2007)
Cytoplasmic dynein nomenclature. (PubMed id 16260502)^{1, 3} Pfister K.K....Vallee R.B. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. (PubMed id 11751937)^{1, 2} Mueller S.... Wimmer E. (2002)
The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. (PubMed id 15992542)^{1, 9} Chuang J.Z....Sung C.H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6993	HGNC: 11697	AceView: TCTEL1	Ensembl:ENSG00000146425	euGenes: HUgn6993
ECgene: DYNLT1	H-InvDB: DYNLT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DYNLT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DYNLT1 gene
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Patent Information for DYNLT1 gene:
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DYNLT1 Gene

dynein, light chain, Tctex-type 1

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DYNLT1 Gene

dynein, light chain, Tctex-type 1

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