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Aliases for DYNLT1 Gene

Aliases for DYNLT1 Gene

  • Dynein, Light Chain, Tctex-Type 1 2 3
  • TCTEL1 3 4 6
  • T-Complex-Associated-Testis-Expressed 1-Like 1 2 3
  • T-Complex Testis-Specific Protein 1 Homolog 3 4
  • Tctex-1 3 4
  • Dynein Light Chain Tctex-Type 1 3
  • Protein CW-1 4
  • TCTEX1 4
  • CW-1 3

External Ids for DYNLT1 Gene

Previous HGNC Symbols for DYNLT1 Gene

  • TCTEL1

Previous GeneCards Identifiers for DYNLT1 Gene

  • GC06M159028
  • GC06M158977
  • GC06M159057
  • GC06M156528

Summaries for DYNLT1 Gene

Entrez Gene Summary for DYNLT1 Gene

  • This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for DYNLT1 Gene

DYNLT1 (Dynein, Light Chain, Tctex-Type 1) is a Protein Coding gene. Among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Lissencephaly gene (LIS1) in neuronal migration and development. GO annotations related to this gene include identical protein binding and motor activity. An important paralog of this gene is DYNLT3.

UniProtKB/Swiss-Prot for DYNLT1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.

  • Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).

Gene Wiki entry for DYNLT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLT1 Gene

Genomics for DYNLT1 Gene

Regulatory Elements for DYNLT1 Gene

Genomic Location for DYNLT1 Gene

Start:
158,636,474 bp from pter
End:
158,644,772 bp from pter
Size:
8,299 bases
Orientation:
Minus strand

Genomic View for DYNLT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNLT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLT1 Gene

Proteins for DYNLT1 Gene

  • Protein details for DYNLT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63172-DYLT1_HUMAN
    Recommended name:
    Dynein light chain Tctex-type 1
    Protein Accession:
    P63172
    Secondary Accessions:
    • Q15763
    • Q5VTU4

    Protein attributes for DYNLT1 Gene

    Size:
    113 amino acids
    Molecular mass:
    12452 Da
    Quaternary structure:
    • Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma (By similarity). Interacts with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry.

neXtProt entry for DYNLT1 Gene

Proteomics data for DYNLT1 Gene at MOPED

Post-translational modifications for DYNLT1 Gene

  • Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).
  • Ubiquitination at Lys56
  • Modification sites at PhosphoSitePlus

Other Protein References for DYNLT1 Gene

No data available for DME Specific Peptides for DYNLT1 Gene

Domains for DYNLT1 Gene

Gene Families for DYNLT1 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNLT1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P63172

UniProtKB/Swiss-Prot:

DYLT1_HUMAN :
  • P63172
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with DYNLT1: view

Function for DYNLT1 Gene

Molecular function for DYNLT1 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein.
UniProtKB/Swiss-Prot Function: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity).

Gene Ontology (GO) - Molecular Function for DYNLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 10644691
GO:0042802 identical protein binding IPI 17965411
genes like me logo Genes that share ontologies with DYNLT1: view

miRNA for DYNLT1 Gene

miRTarBase miRNAs that target DYNLT1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNLT1 Gene

Localization for DYNLT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLT1 Gene

Golgi apparatus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to mitotic spindles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLT1 Gene COMPARTMENTS Subcellular localization image for DYNLT1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
golgi apparatus 2
endosome 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DYNLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IEA --
GO:0005868 cytoplasmic dynein complex ISS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with DYNLT1: view

Pathways for DYNLT1 Gene

genes like me logo Genes that share pathways with DYNLT1: view

Gene Ontology (GO) - Biological Process for DYNLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation ISS --
GO:0007067 mitotic nuclear division IEA --
GO:0008152 metabolic process IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway ISS --
GO:0019060 intracellular transport of viral protein in host cell IMP 18647839
genes like me logo Genes that share ontologies with DYNLT1: view

Transcripts for DYNLT1 Gene

mRNA/cDNA for DYNLT1 Gene

Unigene Clusters for DYNLT1 Gene

Dynein, light chain, Tctex-type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for DYNLT1 Gene

GeneLoc Exon Structure for
DYNLT1
ECgene alternative splicing isoforms for
DYNLT1

Expression for DYNLT1 Gene

mRNA expression in normal human tissues for DYNLT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLT1 Gene

SOURCE GeneReport for Unigene cluster for DYNLT1 Gene Hs.445999

mRNA Expression by UniProt/SwissProt for DYNLT1 Gene

P63172-DYLT1_HUMAN
Tissue specificity: Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).
genes like me logo Genes that share expressions with DYNLT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DYNLT1 Gene

Orthologs for DYNLT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLT1 35
  • 100 (n)
  • 100 (a)
DYNLT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNLT1 35
  • 89.09 (n)
  • 100 (a)
DYNLT1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLT1 35
  • 91.45 (n)
  • 100 (a)
DYNLT1 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlt1a 35
  • 88.5 (n)
  • 93.81 (a)
Dynlt1a 36
  • 94 (a)
OneToMany
Dynlt1b 16
Dynlt1b 36
  • 94 (a)
OneToMany
Dynlt1c 36
  • 94 (a)
OneToMany
Dynlt1f 36
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DYNLT1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLT1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynlt1 35
  • 89.97 (n)
  • 98.23 (a)
chicken
(Gallus gallus)
Aves DYNLT1 35
  • 82.7 (n)
  • 90.57 (a)
DYNLT1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLT1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25778 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlt1 35
  • 78.47 (n)
  • 88.5 (a)
zebrafish
(Danio rerio)
Actinopterygii dynlt1 35
  • 71.39 (n)
  • 71.68 (a)
dynlt1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001229 35
  • 67.27 (n)
  • 78.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dlc90F 35
  • 67.27 (n)
  • 71.17 (a)
Dlc90F 36
  • 71 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14340 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3016 36
  • 81 (a)
OneToOne
Species with no ortholog for DYNLT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYNLT1 Gene

ENSEMBL:
Gene Tree for DYNLT1 (if available)
TreeFam:
Gene Tree for DYNLT1 (if available)

Paralogs for DYNLT1 Gene

Paralogs for DYNLT1 Gene

Selected SIMAP similar genes for DYNLT1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DYNLT1 Gene

genes like me logo Genes that share paralogs with DYNLT1: view

Variants for DYNLT1 Gene

Sequence variations from dbSNP and Humsavar for DYNLT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs882735 -- 158,641,960(-) GTTAA(C/T)GATTC intron-variant
rs1804638 -- 158,636,588(-) TCAAA(C/G)GTGCT utr-variant-3-prime
rs1804639 -- 158,636,705(-) TAGAG(G/T)AAAAA utr-variant-3-prime
rs2306750 -- 158,637,735(+) AAAAC(A/C)ATCCC intron-variant
rs3757077 -- 158,642,728(-) GTCAC(G/T)GTAGT intron-variant

Relevant External Links for DYNLT1 Gene

HapMap Linkage Disequilibrium report
DYNLT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DYNLT1 Gene

Disorders for DYNLT1 Gene

No disorders were found for DYNLT1 Gene.

No data available for UniProtKB/Swiss-Prot for DYNLT1 Gene

Publications for DYNLT1 Gene

  1. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. (PMID: 8646886) Watanabe T.K. … Hirai Y. (Cytogenet. Cell Genet. 1996) 2 3 4
  2. Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. (PMID: 14583445) Machado R.D. … Trembath R.C. (Hum. Mol. Genet. 2003) 3 4 23
  3. Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. (PMID: 15194795) Ohka S. … Nomoto A. (J. Virol. 2004) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. (PMID: 17965411) Lo K.W. … Pfister K.K. (J. Biol. Chem. 2007) 3 4

Products for DYNLT1 Gene

Sources for DYNLT1 Gene

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