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DYNLT1 Gene

protein-coding   GIFtS: 54
GCID: GC06M159057

Dynein, Light Chain, Tctex-Type 1

(Previous name: t-complex-associated-testis-expressed 1-like 1)
(Previous symbol: TCTEL1)
  Search for DYNLT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Light Chain, Tctex-Type 11 2     Dynein Light Chain Tctex-Type 12
TCTEL11 2 3 5     tctex-12
T-Complex-Associated-Testis-Expressed 1-Like 11 2     TCTEX-13
T-Complex Testis-Specific Protein 1 Homolog2 3     TCTEX13
CW-12     Protein CW-13

External Ids:    HGNC: 116971   Entrez Gene: 69932   Ensembl: ENSG000001464257   OMIM: 6015545   UniProtKB: P631723   

Export aliases for DYNLT1 gene to outside databases

Previous GC identifers: GC06M159028 GC06M158977 GC06M156528


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYNLT1 Gene:
Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile
processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of
accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005 (PubMed
15992542)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DYNLT1 Gene:
DYNLT1 (dynein, light chain, Tctex-type 1) is a protein-coding gene. GO annotations related to this gene include motor activity and identical protein binding. An important paralog of this gene is DYNLT3.

UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing
vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to
the cytoplasmic assembly site. May also be a accessory component of axonemal dynein
Function: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to
be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may
be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator
of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a
role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development
presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity)

Gene Wiki entry for DYNLT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNLT1 gene promoter:
         Elk-1   Nkx2-5   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   LCR-F1   POU3F2   MEF-2A   FAC1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNLT1 promoter sequence
   Search Chromatin IP Primers for DYNLT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNLT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.2-q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.2-q25.3

DYNLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLT1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M159057:  view genomic region     (about GC identifiers)

Start:
159,057,506 bp from pter      End:
159,065,804 bp from pter
Size:
8,299 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172 (See protein sequence)
Recommended Name: Dynein light chain Tctex-type 1  
Size: 113 amino acids; 12452 Da
Subunit: Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a
number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and
light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain
homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits.
The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete
for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2.
Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2.
Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding
protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or
DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding
protein G(T) subunit gamma (By similarity). Interacts with human papillomavirus 16 L2 protein; this interaction
is essential for virus intracellular transport during entry
Secondary accessions: Q15763 Q5VTU4

Explore the universe of human proteins at neXtProt for DYNLT1: NX_P63172

Explore proteomics data for DYNLT1 at MOPED

Post-translational modifications: 

  • Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated
    forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation
    status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in
    cytoplasmic dynein cargo release (By similarity)1
  • Ubiquitination2 at Lys56
  • Modification sites at PhosphoSitePlus

  • See DYNLT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006510.1  
    ENSEMBL proteins: 
     ENSP00000356055   ENSP00000356056   ENSP00000356052  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    1 InterPro protein domain:
     IPR005334 Tctex

    Graphical View of Domain Structure for InterPro Entry P63172

    ProtoNet protein and cluster: P63172

    1 Blocks protein domain: IPB005334 Tctex-1 family

    UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172
    Similarity: Belongs to the dynein light chain Tctex-type family


    Find genes that share domains with DYNLT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYLT1_HUMAN, P63172
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing
    vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to
    the cytoplasmic assembly site. May also be a accessory component of axonemal dynein
    Function: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to
    be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may
    be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator
    of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a
    role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development
    presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI10644691
    GO:0042802identical protein binding IPI17965411
         
    Find genes that share ontologies with DYNLT1           About GenesLikeMe


    Animal Models:
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    hsa-miR-374b* hsa-miR-142-5p hsa-miR-3688-3p hsa-miR-29c hsa-miR-29a hsa-miR-3617 hsa-miR-3647-3p hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidDYNLT1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYLT1_HUMAN, P63172: Golgi apparatus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton, spindle
    (By similarity). Note=Localizes to mitotic spindles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    golgi apparatus2
    endosome1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005819spindle IEA--
    GO:0005868cytoplasmic dynein complex ISS--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with DYNLT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYNLT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    3Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    4Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development
    5Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DYNLT1
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF

    2 BioSystems Pathways for DYNLT1
        Lissencephaly gene (LIS1) in neuronal migration and development
    Neurotrophic factor-mediated Trk receptor signaling



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    Interactions:

        GeneGlobe Interaction Network for DYNLT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNLT1 (P631721, 3 ENSP000003560564) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB9Q9BQS61, 3, ENSP000003471784EBI-1176455,EBI-1176448 I2D: score=2 STRING: ENSP00000347178
    NME1-NME2P223923I2D: score=5 
    NME2P223923I2D: score=5 
    FYNP062413, ENSP000003576564I2D: score=4 STRING: ENSP00000357656
    DOC2AQ141833, ENSP000003400174I2D: score=1 STRING: ENSP00000340017
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation ISS--
    GO:0007067mitosis IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway ISS--
    GO:0019060intracellular transport of viral protein in host cell IMP18647839
    GO:0032314regulation of Rac GTPase activity IEA--

    Find genes that share ontologies with DYNLT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYNLT1 (DYLT1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DYNLT1 gene: 
    NM_006519.2  

    Unigene Cluster for DYNLT1:

    Dynein, light chain, Tctex-type 1
    Hs.445999  [show with all ESTs]
    Unigene Representative Sequence: AK026669
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367088 ENST00000367089(uc003qrn.2) ENST00000367085
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    Additional mRNA sequence: 

    AK026669.1 AK315601.1 BC029412.1 BC105588.1 CR456931.1 D50663.1 EU862237.1 U56255.1 

    14 DOTS entries:

    DT.446239  DT.91712992  DT.320052  DT.92439422  DT.95221196  DT.121311728  DT.100824618  DT.121311801 
    DT.91655389  DT.100824616  DT.40110972  DT.91678998  DT.95221269  DT.92439405 

    Selected AceView cDNA sequences (see all 420):

    BU535122 NM_006519 CA868514 N28253 N93287 BM975276 AA393386 BF366257 
    AA398718 AI923679 AA150180 AW024240 AI354316 CR604424 CA842036 BG236477 
    CA432871 AI754151 BM788912 AI824395 W17015 BM708698 AA026142 BE047161 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLT1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:              -                 -     -                                 
    SP2:              -     -           -     -                                 
    SP3:                                -     -     -                           
    SP4:              -                                                         
    SP5:                                                                        


    ECgene alternative splicing isoforms for DYNLT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYNLT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCAGTGA
    DYNLT1 Expression
    About this image

    DYNLT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNLT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445999

    UniProtKB/Swiss-Prot: DYLT1_HUMAN, P63172
    Tissue specificity: Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis,
    ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DYNLT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dynlt1b5
    Dynlt1a1
    dynein light chain Tctex-type 1B5
    dynein light chain Tctex-type 1A1
    88.5(n)1
    93.81(a)1
      17 (3.97 cM)5
    1003108721  NM_001166629.21  NP_001160101.11 
     64301125 
    chicken
    (Gallus gallus)
    Aves DYNLT11 dynein, light chain, Tctex-type 1 82.7(n)
    90.57(a)
      421660  XM_001232356.2  XP_001232357.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYNLT16
    dynein, light chain, Tctex-type 1
    86(a)
    1 ↔ 1
    1(212771690-212784664)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.257782 Xenopus laevis transcribed sequence with moderate similarity more 80(n)    BJ033560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dynlt11 dynein, light chain, Tctex-type 1 71.39(n)
    71.68(a)
      565740  NM_001135783.1  NP_001129255.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dlc90F1 Dynein light chain 90F 67.27(n)
    71.17(a)
      42199  NM_058008.4  NP_477356.1 


    ENSEMBL Gene Tree for DYNLT1 (if available)
    TreeFam Gene Tree for DYNLT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYNLT1 gene
    DYNLT32  
    2 SIMAP similar genes for DYNLT1 using alignment to 3 protein entries:     DYLT1_HUMAN (see all proteins):
    DYNLT3    TCTEX1D2

    Find genes that share paralogs with DYNLT1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DYNLT1
    PGOHUM00000237223 PGOHUM00000245851


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYNLT1 (see all 275)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs624329341,2
    C--159057049(+) CATGGA/GGAGGA 1 -- int12Minor allele frequency- G:0.11NA 122
    rs1421973951,2
    C--159057081(+) TTGGT-/TGTGTAT 1 -- int10--------
    rs132164221,2
    C,F,H--159057085(+) GTTGTA/GTATAT 1 -- int112Minor allele frequency- G:0.21NS EA 1978
    rs1507974901,2
    --159057174(+) CAGTGA/GCGGGA 1 -- int10--------
    rs1138467001,2
    F--159057202(+) GGCTCG/ACTACA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs715511361,2
    C,F--159057273(+) CAGGCA/GCCCGC 1 -- int12Minor allele frequency- G:0.25NA 4
    rs1851965131,2
    C--159057301(+) TTTTGG/TTATTT 1 -- int10--------
    rs1119521251,2
    C,F--159057320(+) GACGGA/GGTTTC 1 -- int12Minor allele frequency- G:0.33NA CSA 3
    rs1885161741,2
    --159057340(+) GACAGA/GATGGT 1 -- int10--------
    rs1123677911,2
    C--159057360(+) CTGACT/CTCATG 1 -- int11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for DYNLT1 (159057506 - 159065804 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DYNLT1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYNLT1
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNLT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601554    OMIM disorders: --


    Find genes that share disorders with DYNLT1           About GenesLikeMe


    Export disorders for DYNLT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYNLT1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with DYNLT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. (PubMed id 8646886)1, 2, 3 Watanabe T.K.... Hirai Y. (Cytogenet. Cell Genet. 1996)
    2. Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. (PubMed id 14583445)1, 2, 9 Machado R.D.... Trembath R.C. (Hum. Mol. Genet. 2003)
    3. Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. (PubMed id 15194795)1, 2, 9 Ohka S....Nomoto A. (J. Virol. 2004)
    4. Identification of the dynein light chains required for human papillomavirus infection. (PubMed id 21166973)1, 2 Schneider M.A.... Lambert C. (Cell. Microbiol. 2011)
    5. D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein. (PubMed id 18647839)1, 2 Vlach J.... Ruml T. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. (PubMed id 17965411)1, 2 Lo K.W.... Pfister K.K. (J. Biol. Chem. 2007)
    7. Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. (PubMed id 16880273)1, 2 Takizawa N.... Luna E.J. (J. Cell Biol. 2006)
    8. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (J. Cell Biol. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. (PubMed id 11751937)1, 2 Mueller S.... Wimmer E. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6993 HGNC: 11697 AceView: TCTEL1 Ensembl:ENSG00000146425 euGenes: HUgn6993
    ECgene: DYNLT1 H-InvDB: DYNLT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNLT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYNLT1 gene:
    Search GeneIP for patents involving DYNLT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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