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Aliases for DYNLRB2 Gene

Aliases for DYNLRB2 Gene

  • Dynein, Light Chain, Roadblock-Type 2 2 3
  • DNCL2B 3 4 6
  • Dynein, Cytoplasmic, Light Polypeptide 2B 2 3
  • Roadblock Domain-Containing Protein 2 3 4
  • Dynein Light Chain 2B, Cytoplasmic 3 4
  • DNLC2B 3 4
  • ROBLD2 3 4
  • Dynein Light Chain Roadblock-Type 2 3
  • Roadblock Domain Containing 2 2
  • Bithoraxoid-Like Protein 3

External Ids for DYNLRB2 Gene

Previous Symbols for DYNLRB2 Gene

  • DNCL2B

Summaries for DYNLRB2 Gene

GeneCards Summary for DYNLRB2 Gene

DYNLRB2 (Dynein, Light Chain, Roadblock-Type 2) is a Protein Coding gene. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB1.

UniProtKB/Swiss-Prot for DYNLRB2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLRB2 Gene

Genomics for DYNLRB2 Gene

Genomic Location for DYNLRB2 Gene

Start:
80,540,734 bp from pter
End:
80,550,816 bp from pter
Size:
10,083 bases
Orientation:
Plus strand

Genomic View for DYNLRB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNLRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLRB2 Gene

Regulatory Elements for DYNLRB2 Gene

Proteins for DYNLRB2 Gene

  • Protein details for DYNLRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF09-DLRB2_HUMAN
    Recommended name:
    Dynein light chain roadblock-type 2
    Protein Accession:
    Q8TF09
    Secondary Accessions:

    Protein attributes for DYNLRB2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10855 Da
    Quaternary structure:
    • Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1.
    Miscellaneous:
    • Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients

neXtProt entry for DYNLRB2 Gene

Proteomics data for DYNLRB2 Gene at MOPED

Post-translational modifications for DYNLRB2 Gene

Other Protein References for DYNLRB2 Gene

No data available for DME Specific Peptides for DYNLRB2 Gene

Domains for DYNLRB2 Gene

Gene Families for DYNLRB2 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNLRB2 Gene

UniProtKB/Swiss-Prot:

DLRB2_HUMAN
Family:
  • Belongs to the GAMAD family.:
    • Q8TF09
genes like me logo Genes that share domains with DYNLRB2: view

Function for DYNLRB2 Gene

Molecular function for DYNLRB2 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules

Gene Ontology (GO) - Molecular Function for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 11750132
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DYNLRB2: view

Phenotypes for DYNLRB2 Gene

genes like me logo Genes that share phenotypes with DYNLRB2: view

miRNA for DYNLRB2 Gene

miRTarBase miRNAs that target DYNLRB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNLRB2 Gene

Localization for DYNLRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLRB2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLRB2 Gene COMPARTMENTS Subcellular localization image for DYNLRB2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005868 cytoplasmic dynein complex NAS 11750132
GO:0005874 microtubule IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072372 primary cilium TAS --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with DYNLRB2: view

Pathways for DYNLRB2 Gene

genes like me logo Genes that share pathways with DYNLRB2: view

Pathways by source for DYNLRB2 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for DYNLRB2 Gene

Gene Ontology (GO) - Biological Process for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006996 organelle organization TAS --
GO:0007018 microtubule-based movement NAS 11750132
GO:0008152 metabolic process NAS 11750132
genes like me logo Genes that share ontologies with DYNLRB2: view

Transcripts for DYNLRB2 Gene

Unigene Clusters for DYNLRB2 Gene

Dynein, light chain, roadblock-type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for DYNLRB2 Gene

GeneLoc Exon Structure for
DYNLRB2
ECgene alternative splicing isoforms for
DYNLRB2

Expression for DYNLRB2 Gene

mRNA expression in normal human tissues for DYNLRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYNLRB2 Gene

This gene is overexpressed in Testis (29.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DYNLRB2 Gene

SOURCE GeneReport for Unigene cluster for DYNLRB2 Gene Hs.98849

mRNA Expression by UniProt/SwissProt for DYNLRB2 Gene

Q8TF09-DLRB2_HUMAN
Tissue specificity: High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte
genes like me logo Genes that share expressions with DYNLRB2: view

Orthologs for DYNLRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLRB2 36
  • 100 (n)
  • 100 (a)
DYNLRB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNLRB2 36
  • 93.4 (n)
  • 98.96 (a)
DYNLRB2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLRB2 36
  • 92.01 (n)
  • 98.96 (a)
DYNLRB2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlrb2 36
  • 88.19 (n)
  • 97.92 (a)
Dynlrb2 16
Dynlrb2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNLRB2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 41 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dynlrb2 36
  • 85.42 (n)
  • 97.92 (a)
chicken
(Gallus gallus)
Aves DYNLRB2 36
  • 81.94 (n)
  • 92.71 (a)
DYNLRB2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLRB2 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6973 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlrb2 36
  • 79.86 (n)
  • 95.83 (a)
Str.10857 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13879 36
zebrafish
(Danio rerio)
Actinopterygii DYNLRB2 37
  • 74 (a)
OneToOne
si:ch211-147k9.8 36
  • 77.08 (n)
  • 86.46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003360 36
  • 65.96 (n)
  • 75.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16837 37
  • 23 (a)
OneToMany
robl 36
  • 67.73 (n)
  • 75.53 (a)
robl37BC 37
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14206 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 84 (a)
OneToOne
Species with no ortholog for DYNLRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYNLRB2 Gene

ENSEMBL:
Gene Tree for DYNLRB2 (if available)
TreeFam:
Gene Tree for DYNLRB2 (if available)

Paralogs for DYNLRB2 Gene

Paralogs for DYNLRB2 Gene

Selected SIMAP similar genes for DYNLRB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DYNLRB2: view

Variants for DYNLRB2 Gene

Sequence variations from dbSNP and Humsavar for DYNLRB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_049126 -

Structural Variations from Database of Genomic Variants (DGV) for DYNLRB2 Gene

Variant ID Type Subtype PubMed ID
nsv907001 CNV Gain 21882294
nsv833300 CNV Gain 17160897

Relevant External Links for DYNLRB2 Gene

HapMap Linkage Disequilibrium report
DYNLRB2
Human Gene Mutation Database (HGMD)
DYNLRB2

Disorders for DYNLRB2 Gene

Relevant External Links for DYNLRB2

Genetic Association Database (GAD)
DYNLRB2
Human Genome Epidemiology (HuGE) Navigator
DYNLRB2
genes like me logo Genes that share disorders with DYNLRB2: view

No data available for UniProtKB/Swiss-Prot for DYNLRB2 Gene

Publications for DYNLRB2 Gene

  1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PMID: 11750132) Jiang J. … Zhao S. (Gene 2001) 2 3 4 23
  2. The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PMID: 12077152) Susalka S.J. … Pfister K.K. (J. Biol. Chem. 2002) 3 4
  3. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for DYNLRB2 Gene

Sources for DYNLRB2 Gene

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