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DYNLRB2 Gene

protein-coding   GIFtS: 56
GCID: GC16P080574

Dynein, Light Chain, Roadblock-Type 2

(Previous names: dynein, cytoplasmic, light polypeptide 2B)
(Previous symbol: DNCL2B)
  Search for DYNLRB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Light Chain, Roadblock-Type 21 2     Roadblock Domain-Containing Protein 22 3
DNCL2B1 2 3 5     DNLC2B2 3
Dynein, Cytoplasmic, Light Polypeptide 2B1 2     ROBLD22 3
Roadblock Domain Containing 21 2     Bithoraxoid-Like Protein2
Dynein Light Chain 2B, Cytoplasmic2 3     Dynein Light Chain Roadblock-Type 22

External Ids:    HGNC: 154671   Entrez Gene: 836572   Ensembl: ENSG000001685897   OMIM: 6071685   UniProtKB: Q8TF093   

Export aliases for DYNLRB2 gene to outside databases

Previous GC identifers: GC16P079133 GC16P066331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DYNLRB2 Gene:
DYNLRB2 (dynein, light chain, roadblock-type 2) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB1.

UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNLRB2 gene promoter:
         MEF-2A   Nkx3-1 v4   POU2F1   AML1a   GATA-3   POU2F1a   aMEF-2   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNLRB2 promoter sequence
   Search Chromatin IP Primers for DYNLRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNLRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.2   HGNC cytogenetic band: 16q23.3

DYNLRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLRB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P080574:  view genomic region     (about GC identifiers)

Start:
80,574,631 bp from pter      End:
80,584,657 bp from pter
Size:
10,027 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 (See protein sequence)
Recommended Name: Dynein light chain roadblock-type 2  
Size: 96 amino acids; 10855 Da
Subunit: Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a
number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and
light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain
homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits.
The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and
DYNC1I2. Self-associates. Interacts with DYNLRB1
Miscellaneous: Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients

Explore the universe of human proteins at neXtProt for DYNLRB2: NX_Q8TF09

Explore proteomics data for DYNLRB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9

  • See DYNLRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_570967.1  
    ENSEMBL proteins: 
     ENSP00000455791   ENSP00000302936   ENSP00000454846   ENSP00000342009   ENSP00000455216  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    2 InterPro protein domains:
     IPR016561 Dynein_light_roadblock-type
     IPR004942 Dynein_light-rel

    Graphical View of Domain Structure for InterPro Entry Q8TF09

    ProtoNet protein and cluster: Q8TF09

    1 Blocks protein domain: IPB004942 Roadblock/LC7 family

    UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
    Similarity: Belongs to the GAMAD family


    Find genes that share domains with DYNLRB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLRB2_HUMAN, Q8TF09
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity NAS11750132
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DYNLRB2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DYNLRB2:
     Increased cell number in G2M,   Increased viability after born 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYNLRB2
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    hsa-mir-335-5p (MIRT018162)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DLRB2_HUMAN, Q8TF09: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005868cytoplasmic dynein complex NAS11750132
    GO:0005874microtubule IEA--

    Find genes that share ontologies with DYNLRB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYNLRB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    3Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DYNLRB2
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYNLRB2
    Interactions:

        Search GeneGlobe Interaction Network for DYNLRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNLRB2 (Q8TF093 ENSP000003029364) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    PRKCDQ056553I2D: score=2 
    CCNB1P146353I2D: score=1 
    EEF1DP296923I2D: score=1 
    PRKAB2O437413I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007018microtubule-based movement NAS11750132
    GO:0008152metabolic process NAS11750132

    Find genes that share ontologies with DYNLRB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYNLRB2 (DLRB2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DYNLRB2 gene: 
    NM_130897.1  

    Unigene Cluster for DYNLRB2:

    Dynein, light chain, roadblock-type 2
    Hs.98849  [show with all ESTs]
    Unigene Representative Sequence: BC035232
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562982 ENST00000305904(uc002ffo.3) ENST00000568035 ENST00000338542(uc002ffp.3)
    ENST00000561880(uc002ffq.3) ENST00000570222
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat DYNLRB2

    Additional mRNA sequence: 

    AF125108.1 BC035232.1 BC054892.1 

    5 DOTS entries:

    DT.97778290  DT.95154196  DT.100019166  DT.75196573  DT.120656292 

    24 AceView cDNA sequences:

    AA435968 AI826656 AA446298 BC054892 AA872500 AA719152 CD676360 AI026825 
    AA961187 BI830575 AA769674 BX340151 BC035232 AA446025 BQ109457 AI023522 
    AF125108 AA300900 BM668600 NM_130897 BP370813 AA928442 AL043981 AW959427 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                -                     
    SP2:        -     -           -     -                     
    SP3:                          -     -                     
    SP4:                          -                           


    ECgene alternative splicing isoforms for DYNLRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYNLRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTATTAAAA
    DYNLRB2 Expression
    About this image


    DYNLRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Testis (Reproductive System)
    DYNLRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNLRB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98849

    UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
    Tissue specificity: High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine;
    moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DYNLRB2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dynlrb21 , 5 dynein light chain roadblock-type 21, 5 88.19(n)1
    97.92(a)1
      8 (63.07 cM)5
    754651  NM_029297.11  NP_083573.11 
     1165050155 
    chicken
    (Gallus gallus)
    Aves DYNLRB21 dynein, light chain, roadblock-type 2 81.94(n)
    92.71(a)
      415802  NM_001277615.1  NP_001264544.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYNLRB26
    dynein, light chain, roadblock-type 2
    96(a)
    1 ↔ 1
    LGc(5521569-5529762)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69732 Xenopus laevis transcribed sequence with strong similarity more 81.46(n)    48031332 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-147k9.81 si:ch211-147k9.8 77.08(n)
    86.46(a)
      100001191  XM_001341208.4  XP_001341244.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta robl1 roadblock 67.73(n)
    75.53(a)
      36963  NM_079047.3  NP_523771.1 


    ENSEMBL Gene Tree for DYNLRB2 (if available)
    TreeFam Gene Tree for DYNLRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYNLRB2 gene
    DYNLRB12  
    1 SIMAP similar gene for DYNLRB2 using alignment to 5 protein entries:     DLRB2_HUMAN (see all proteins):
    DYNLRB1

    Find genes that share paralogs with DYNLRB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for DYNLRB2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133322891,2,4
    ----see VAR_0491262 mis40--------

    HapMap Linkage Disequilibrium report for DYNLRB2 (80574631 - 80584657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYNLRB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833300CNV Gain17160897
    nsv907001CNV Gain21882294

    Human Gene Mutation Database (HGMD): DYNLRB2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DYNLRB2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607168    OMIM disorders: --


    Find genes that share disorders with DYNLRB2           About GenesLikeMe

    Genetic Association Database (GAD): DYNLRB2
    Human Genome Epidemiology (HuGE) Navigator: DYNLRB2 (2 documents)

    Export disorders for DYNLRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYNLRB2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DYNLRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PubMed id 11750132)1, 2, 3, 9 Jiang J.... Zhao S. (Gene 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    4. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (J. Cell Biol. 2005)
    5. The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PubMed id 12077152)1, 2 Susalka S.J.... Pfister K.K. (J. Biol. Chem. 2002)
    6. Genome-wide association study of antiphospholipid antibodies. (PubMed id 23509613)1 Kamboh M.I....Demirci F.Y. (Autoimmune Dis 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83657 HGNC: 15467 AceView: DNCL2B Ensembl:ENSG00000168589 euGenes: HUgn83657
    ECgene: DYNLRB2 H-InvDB: DYNLRB2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNLRB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYNLRB2 gene:
    Search GeneIP for patents involving DYNLRB2

    GeneCards and IP:
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