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Aliases for DYNLRB2 Gene

Aliases for DYNLRB2 Gene

  • Dynein Light Chain Roadblock-Type 2 2 3
  • Dynein, Cytoplasmic, Light Polypeptide 2B 2 3
  • Roadblock Domain-Containing Protein 2 3 4
  • Dynein, Light Chain, Roadblock-Type 2 3 5
  • Dynein Light Chain 2B, Cytoplasmic 3 4
  • DNCL2B 3 4
  • DNLC2B 3 4
  • ROBLD2 3 4
  • Testicular Tissue Protein Li 53 3
  • Roadblock Domain Containing 2 2
  • Bithoraxoid-Like Protein 3

External Ids for DYNLRB2 Gene

Previous HGNC Symbols for DYNLRB2 Gene

  • DNCL2B

Previous GeneCards Identifiers for DYNLRB2 Gene

  • GC16P079133
  • GC16P080574
  • GC16P066331

Summaries for DYNLRB2 Gene

GeneCards Summary for DYNLRB2 Gene

DYNLRB2 (Dynein Light Chain Roadblock-Type 2) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Cell cycle_Spindle assembly and chromosome separation. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB1.

UniProtKB/Swiss-Prot for DYNLRB2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLRB2 Gene

Genomics for DYNLRB2 Gene

Regulatory Elements for DYNLRB2 Gene

Enhancers for DYNLRB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DYNLRB2 on UCSC Golden Path with GeneCards custom track

Promoters for DYNLRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DYNLRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DYNLRB2 Gene

Chromosome:
16
Start:
80,540,258 bp from pter
End:
80,550,811 bp from pter
Size:
10,554 bases
Orientation:
Plus strand

Genomic View for DYNLRB2 Gene

Genes around DYNLRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLRB2 Gene

Proteins for DYNLRB2 Gene

  • Protein details for DYNLRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF09-DLRB2_HUMAN
    Recommended name:
    Dynein light chain roadblock-type 2
    Protein Accession:
    Q8TF09

    Protein attributes for DYNLRB2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10855 Da
    Quaternary structure:
    • Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2. Self-associates. Interacts with DYNLRB1.
    Miscellaneous:
    • Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.

neXtProt entry for DYNLRB2 Gene

Proteomics data for DYNLRB2 Gene at MOPED

Post-translational modifications for DYNLRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNLRB2 Gene

No data available for DME Specific Peptides for DYNLRB2 Gene

Domains & Families for DYNLRB2 Gene

Gene Families for DYNLRB2 Gene

Protein Domains for DYNLRB2 Gene

Suggested Antigen Peptide Sequences for DYNLRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF09

UniProtKB/Swiss-Prot:

DLRB2_HUMAN :
  • Belongs to the GAMAD family.
Family:
  • Belongs to the GAMAD family.
genes like me logo Genes that share domains with DYNLRB2: view

Function for DYNLRB2 Gene

Molecular function for DYNLRB2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Gene Ontology (GO) - Molecular Function for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with DYNLRB2: view
genes like me logo Genes that share phenotypes with DYNLRB2: view

Animal Models for DYNLRB2 Gene

MGI Knock Outs for DYNLRB2:

Animal Model Products

CRISPR Products

miRNA for DYNLRB2 Gene

miRTarBase miRNAs that target DYNLRB2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYNLRB2 Gene

Localization for DYNLRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLRB2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLRB2 Gene COMPARTMENTS Subcellular localization image for DYNLRB2 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005868 cytoplasmic dynein complex IEA,NAS 11750132
GO:0070062 extracellular exosome IDA 23376485
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with DYNLRB2: view

Pathways & Interactions for DYNLRB2 Gene

genes like me logo Genes that share pathways with DYNLRB2: view

Pathways by source for DYNLRB2 Gene

Gene Ontology (GO) - Biological Process for DYNLRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006996 organelle organization TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DYNLRB2: view

No data available for SIGNOR curated interactions for DYNLRB2 Gene

Drugs & Compounds for DYNLRB2 Gene

No Compound Related Data Available

Transcripts for DYNLRB2 Gene

Unigene Clusters for DYNLRB2 Gene

Dynein, light chain, roadblock-type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for DYNLRB2 Gene

GeneLoc Exon Structure for
DYNLRB2
ECgene alternative splicing isoforms for
DYNLRB2

Expression for DYNLRB2 Gene

mRNA expression in normal human tissues for DYNLRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYNLRB2 Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for DYNLRB2 Gene

This gene is overexpressed in Brain (22.4), Plasma (21.5), Heart (14.4), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DYNLRB2 Gene



SOURCE GeneReport for Unigene cluster for DYNLRB2 Gene Hs.98849

mRNA Expression by UniProt/SwissProt for DYNLRB2 Gene

Q8TF09-DLRB2_HUMAN
Tissue specificity: High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte.
genes like me logo Genes that share expression patterns with DYNLRB2: view

Protein tissue co-expression partners for DYNLRB2 Gene

- Elite partner

Primer Products

Orthologs for DYNLRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DYNLRB2 35
  • 93.4 (n)
  • 98.96 (a)
DYNLRB2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLRB2 35
  • 92.01 (n)
  • 98.96 (a)
DYNLRB2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlrb2 35
  • 88.19 (n)
  • 97.92 (a)
Dynlrb2 16
Dynlrb2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYNLRB2 35
  • 100 (n)
  • 100 (a)
DYNLRB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynlrb2 35
  • 85.42 (n)
  • 97.92 (a)
oppossum
(Monodelphis domestica)
Mammalia DYNLRB2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
chicken
(Gallus gallus)
Aves DYNLRB2 35
  • 81.94 (n)
  • 92.71 (a)
DYNLRB2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLRB2 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlrb2 35
  • 79.86 (n)
  • 95.83 (a)
Str.10857 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6973 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-147k9.8 35
  • 77.08 (n)
  • 86.46 (a)
DYNLRB2 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13879 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003360 35
  • 65.96 (n)
  • 75.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta robl 35
  • 67.73 (n)
  • 75.53 (a)
CG16837 36
  • 23 (a)
OneToMany
robl37BC 36
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14206 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 84 (a)
OneToOne
Species with no ortholog for DYNLRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYNLRB2 Gene

ENSEMBL:
Gene Tree for DYNLRB2 (if available)
TreeFam:
Gene Tree for DYNLRB2 (if available)

Paralogs for DYNLRB2 Gene

Paralogs for DYNLRB2 Gene

(1) SIMAP similar genes for DYNLRB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DYNLRB2: view

Variants for DYNLRB2 Gene

Sequence variations from dbSNP and Humsavar for DYNLRB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_049126 -

Structural Variations from Database of Genomic Variants (DGV) for DYNLRB2 Gene

Variant ID Type Subtype PubMed ID
nsv907001 CNV Gain 21882294
nsv833300 CNV Gain 17160897

Variation tolerance for DYNLRB2 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNLRB2 Gene

Human Gene Mutation Database (HGMD)
DYNLRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLRB2 Gene

Disorders for DYNLRB2 Gene

Relevant External Links for DYNLRB2

Genetic Association Database (GAD)
DYNLRB2
Human Genome Epidemiology (HuGE) Navigator
DYNLRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNLRB2

No disorders were found for DYNLRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNLRB2 Gene

Publications for DYNLRB2 Gene

  1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PMID: 11750132) Jiang J. … Zhao S. (Gene 2001) 2 3 4 23 67
  2. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Genome-wide association study of antiphospholipid antibodies. (PMID: 23509613) Kamboh M.I. … Demirci F.Y. (Autoimmune Dis 2013) 3

Products for DYNLRB2 Gene

Sources for DYNLRB2 Gene

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