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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYNLRB2 Gene

protein-coding   GIFtS: 53
GCID: GC16P080574

dynein, light chain, roadblock-type 2

(Previous names: dynein, cytoplasmic, light polypeptide 2B )
(Previous symbol: DNCL2B)
 Explore 5 diseases affiliated with
DYNLRB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DYNLRB2    

Aliases
for DYNLRB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dynein, Light Chain, Roadblock-Type 21 2     Dynein Light Chain 2B, Cytoplasmic2 3
DNCL2B1 2 3 5     Roadblock Domain-Containing Protein 22 3
DNLC2B1 2 3     Bithoraxoid-Like Protein2
ROBLD21 2 3     Dynein Light Chain Roadblock-Type 22
Dynein, Cytoplasmic, Light Polypeptide 2B1 2     Roadblock Domain Containing 22

External Ids:    HGNC: 154671   Entrez Gene: 836572   Ensembl: ENSG000001685897   OMIM: 6071685   UniProtKB: Q8TF093   

Export aliases for DYNLRB2 gene to outside databases

Previous GC identifers: GC16P079133 GC16P066331


Summaries
for DYNLRB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic
dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules




Genomic Views
for DYNLRB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYNLRB2 gene promoter:
         MEF-2A   Nkx3-1 v4   POU2F1   AML1a   GATA-3   POU2F1a   aMEF-2   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYNLRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYNLRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.2   HGNC cytogenetic band: 16q23.3

DYNLRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLRB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P080574:  view genomic region     (about GC identifiers)

Start:
 80,574,631 bp from pter      End:
 80,584,657 bp from pter
Size:
 10,027 bases      Orientation:
 plus strand

Proteins
for DYNLRB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09 (See protein sequence)
Recommended Name: Dynein light chain roadblock-type 2  
Size: 96 amino acids; 10855 Da
Subunit: Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a
number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light
chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer
serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs
bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1 and DYNC1I2.
Self-associates. Interacts with DYNLRB1
Subcellular location: Cytoplasm, cytoskeleton
Miscellaneous: Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients

Explore the universe of human proteins at neXtProt for DYNLRB2: NX_Q8TF09

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TF09

    • DYNLRB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_570967.1  
    ENSEMBL proteins: 
     ENSP00000455791   ENSP00000302936   ENSP00000454846   ENSP00000342009   ENSP00000455216  

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    ProSpec Recombinant Protein for DYNLRB2
    Uscn Proteins for DYNLRB2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005868cytoplasmic dynein complex NAS11750132
    GO:0005874microtubule IEA--


    DYNLRB2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DYNLRB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DYNLRB2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016561 Dynein_light_roadblock-type
     IPR004942 Dynein_light-rel

    Graphical View of Domain Structure for InterPro Entry Q8TF09

    ProtoNet protein and cluster: Q8TF09

    1 Blocks protein family: IPB004942 Roadblock/LC7 family

    UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
    Similarity: Belongs to the GAMAD family


    Function
    for DYNLRB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic
    dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules

    miRNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity NAS11750132
    GO:0005515protein binding ----


    DYNLRB2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DYNLRB2:
     Increased cell number in G2M,   Increased viability after born 


    Pathways & Interactions
    for DYNLRB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    2Regulation of degradation of wt-CFTR
    		Regulation of degradation of deltaF508 CFTR in CF0.59
    3Cytoskeleton remodeling Neurofilaments
    		Cytoplasmic microtubules0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for DYNLRB2
        Cell cycle Spindle assembly and chromosome separation
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DYNLRB2
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF



    DYNLRB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNLRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for DYNLRB2 (Q8TF093 ENSP000003029364) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056553I2D: score=2 
    APPP050673I2D: score=1 
    CCNB1P146353I2D: score=1 
    EEF1DP296923I2D: score=1 
    PRKAB2O437413I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007018microtubule-based movement NAS11750132


    DYNLRB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DYNLRB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DYNLRB2
    Search CenterWatch for drugs/clinical trials and news about DYNLRB2 / DLRB2 

    Transcripts
    for DYNLRB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DYNLRB2 gene: 
    NM_130897.1  

    Unigene Cluster for DYNLRB2:

    Dynein, light chain, roadblock-type 2
    Hs.98849  [show with all ESTs]
    Unigene Representative Sequence: BC035232
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562982 ENST00000305904(uc002ffo.3) ENST00000568035 ENST00000338542(uc002ffp.3)
    ENST00000561880(uc002ffq.3) ENST00000570222

    miRNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLRB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLRB2

    Additional cDNA sequence: 

    AF125108.1 BC035232.1 BC054892.1 

    5 DOTS entries:

    DT.97778290  DT.95154196  DT.100019166  DT.75196573  DT.120656292 

    24 AceView cDNA sequences:

    BC054892 AA435968 AI826656 AA446298 CD676360 BX340151 AA719152 AA769674 
    AI023522 AA872500 BQ109457 BI830575 AA446025 BC035232 AI026825 AA961187 
    AF125108 AA300900 BM668600 NM_130897 BP370813 AA928442 AW959427 AL043981 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                -                     
    SP2:        -     -           -     -                     
    SP3:                          -     -                     
    SP4:                          -                           


    ECgene alternative splicing isoforms for DYNLRB2

    Expression
    for DYNLRB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYNLRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTATTAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DYNLRB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    Posterior foregut-like cells (A scalable, suspensi...)

    See DYNLRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYNLRB2

    SOURCE GeneReport for Unigene cluster: Hs.98849

    UniProtKB/Swiss-Prot: DLRB2_HUMAN, Q8TF09
    Tissue specificity: High expression in heart, brain, placenta, skeletal muscle, prostate and small intestine; moderate
    in kidney, pancreas, spleen, testis, ovary and colon; low in lung, liver, thymus and leukocyte

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    In Situ
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    Orthologs
    for DYNLRB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DYNLRB2 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DYNLRB21 dynein, light chain, roadblock-type 2 81.94(n)
    92.71(a)    		   415802  XM_414162.3  XP_414162.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DYNLRB26
    		 --
    		 95(a)
    		 1 ↔ 1
    		 LGc(5524878-5529671)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.69732 Xenopus laevis transcribed sequence with strong similarity more 81.46(n)    48031332 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000011911 dynein light chain roadblock-type 2-like 77.08(n)
    86.46(a)    		   100001191  XM_001341208.3  XP_001341244.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta robl1 roadblock 67.73(n)
    75.53(a)    		   36963  NM_079047.3  NP_523771.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dyrb-16
    		 DYnein light chain (RoadBlock type) family member ...
    		 24(a)
    		 1 → many
    		 II(9106452-9107201)


    ENSEMBL Gene Tree for DYNLRB2 (if available)
    TreeFam Gene Tree for DYNLRB2 (if available) 

    Paralogs
    for DYNLRB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYNLRB2 gene
    DYNLRB12  
    1 SIMAP similar gene for DYNLRB2 using alignment to 5 protein entries:     DLRB2_HUMAN (see all proteins):
    DYNLRB1

    DYNLRB2 for paralogs           About GeneDecksing



    Genomic Variants
    for DYNLRB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): DYNLRB2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNLRB2
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNLRB2

    Disorders / Diseases
    for DYNLRB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DYNLRB2 for disorders           About GeneDecksing

    OMIM gene information: 607168    OMIM disorders: --

    5 diseases for DYNLRB2:    About MalaCards
    hepatocellular carcinoma    cholesterol    carcinoma    malaria
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: DYNLRB2 (2 documents)

    Export disorders for DYNLRB2 gene to outside databases

    Publications
    for DYNLRB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYNLRB2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DYNLRB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PubMed id 11750132)1, 2, 3, 9 Jiang J.... Zhao S. (2001)
    2. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
    3. The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PubMed id 12077152)1, 2 Susalka S.J....Pfister K.K. (2002)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
    9. Requirement of a dynein light chain in TGFbeta/Smad3 signaling. (PubMed id 19711352)1 Jin Q....Mulder K.M. (2009)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1 Gevaert K.... Vandekerckhove J. (2003)

    External Searches for DYNLRB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DYNLRB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83657 HGNC: 15467 AceView: DNCL2B Ensembl:ENSG00000168589 euGenes: HUgn83657
    ECgene: DYNLRB2 H-InvDB: DYNLRB2

    Other Databases showing DYNLRB2 gene

    (According to HUGE)
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    Specialized Databases showing DYNLRB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNLRB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    		Patent Information for DYNLRB2 gene:
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