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Aliases for DYNLRB1 Gene

Aliases for DYNLRB1 Gene

  • Dynein, Light Chain, Roadblock-Type 1 2 3
  • DNCL2A 3 4 6
  • DNLC2A 3 4 6
  • Dynein, Cytoplasmic, Light Polypeptide 2A 2 3
  • Roadblock Domain-Containing Protein 1 3 4
  • Dynein-Associated Protein Km23 3 4
  • Bithoraxoid-Like Protein 3 4
  • ROBLD1 3 4
  • BITH 3 4
  • BLP 3 4
  • Dynein Light Chain Roadblock-Type 1 3
  • Dynein Light Chain 2A, Cytoplasmic 4
  • Roadblock Domain Containing 1 2
  • ROBL/LC7-Like 1 3

External Ids for DYNLRB1 Gene

Previous Symbols for DYNLRB1 Gene

  • DNCL2A

Summaries for DYNLRB1 Gene

Entrez Gene Summary for DYNLRB1 Gene

  • This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

GeneCards Summary for DYNLRB1 Gene

DYNLRB1 (Dynein, Light Chain, Roadblock-Type 1) is a Protein Coding gene. Among its related pathways are TGF-beta receptor signaling and Cell cycle_Spindle assembly and chromosome separation. GO annotations related to this gene include identical protein binding and microtubule motor activity. An important paralog of this gene is DYNLRB2.

UniProtKB/Swiss-Prot for DYNLRB1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules

Gene Wiki entry for DYNLRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLRB1 Gene

Genomics for DYNLRB1 Gene

Genomic Location for DYNLRB1 Gene

Start:
34,516,364 bp from pter
End:
34,540,958 bp from pter
Size:
24,595 bases
Orientation:
Plus strand

Genomic View for DYNLRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNLRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLRB1 Gene

Regulatory Elements for DYNLRB1 Gene

Proteins for DYNLRB1 Gene

  • Protein details for DYNLRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP97-DLRB1_HUMAN
    Recommended name:
    Dynein light chain roadblock-type 1
    Protein Accession:
    Q9NP97
    Secondary Accessions:
    • B1AKR5
    • Q5TC72
    • Q96IV3
    • Q9NQM2

    Protein attributes for DYNLRB1 Gene

    Size:
    96 amino acids
    Molecular mass:
    10922 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNLRB2. Interacts with DYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct. Interacts with RAB6A isoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound).

    Three dimensional structures from OCA and Proteopedia for DYNLRB1 Gene

    Alternative splice isoforms for DYNLRB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNLRB1 Gene

Proteomics data for DYNLRB1 Gene at MOPED

Post-translational modifications for DYNLRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys15, Lys31, Lys52, and Lys84

Other Protein References for DYNLRB1 Gene

No data available for DME Specific Peptides for DYNLRB1 Gene

Domains for DYNLRB1 Gene

Gene Families for DYNLRB1 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNLRB1 Gene

UniProtKB/Swiss-Prot:

DLRB1_HUMAN
Family:
  • Belongs to the GAMAD family.:
    • Q9NP97
genes like me logo Genes that share domains with DYNLRB1: view

Function for DYNLRB1 Gene

Molecular function for DYNLRB1 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules

Gene Ontology (GO) - Molecular Function for DYNLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 11750132
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DYNLRB1: view

Phenotypes for DYNLRB1 Gene

MGI mutant phenotypes for DYNLRB1:
inferred from 1 alleles
GenomeRNAi human phenotypes for DYNLRB1:
genes like me logo Genes that share phenotypes with DYNLRB1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DYNLRB1 Gene

Localization for DYNLRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLRB1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLRB1 Gene COMPARTMENTS Subcellular localization image for DYNLRB1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DYNLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005813 centrosome IDA 21399614
GO:0005868 cytoplasmic dynein complex NAS 11750132
GO:0005874 microtubule IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DYNLRB1: view

Pathways for DYNLRB1 Gene

genes like me logo Genes that share pathways with DYNLRB1: view

Pathways by source for DYNLRB1 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for DYNLRB1 Gene
1 BioSystems pathway for DYNLRB1 Gene

Gene Ontology (GO) - Biological Process for DYNLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006996 organelle organization TAS --
GO:0007018 microtubule-based movement NAS 11750132
GO:0007632 visual behavior ISS --
GO:0008152 metabolic process NAS 11750132
genes like me logo Genes that share ontologies with DYNLRB1: view

Transcripts for DYNLRB1 Gene

Unigene Clusters for DYNLRB1 Gene

Dynein, light chain, roadblock-type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for DYNLRB1 Gene

GeneLoc Exon Structure for
DYNLRB1
ECgene alternative splicing isoforms for
DYNLRB1

Expression for DYNLRB1 Gene

mRNA expression in normal human tissues for DYNLRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLRB1 Gene

SOURCE GeneReport for Unigene cluster for DYNLRB1 Gene Hs.593920

mRNA Expression by UniProt/SwissProt for DYNLRB1 Gene

Q9NP97-DLRB1_HUMAN
Tissue specificity: High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.
genes like me logo Genes that share expressions with DYNLRB1: view

Orthologs for DYNLRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLRB1 36
  • 100 (n)
  • 100 (a)
DYNLRB1 37
  • 64 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNLRB1 36
  • 93.4 (n)
  • 96.87 (a)
DYNLRB1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLRB1 36
  • 94.1 (n)
  • 96.87 (a)
DYNLRB1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlrb1 36
  • 91.32 (n)
  • 96.87 (a)
Dynlrb1 16
Dynlrb1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNLRB1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynlrb1 36
  • 90.97 (n)
  • 96.87 (a)
chicken
(Gallus gallus)
Aves DYNLRB1 36
  • 84.03 (n)
  • 93.75 (a)
DYNLRB1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLRB1 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlrb1 36
  • 78.47 (n)
  • 83.33 (a)
zebrafish
(Danio rerio)
Actinopterygii dynlrb1 36
  • 74.31 (n)
  • 80.21 (a)
dynlrb1 37
  • 80 (a)
OneToOne
zgc56335 36
fruit fly
(Drosophila melanogaster)
Insecta CG10822 37
  • 26 (a)
OneToMany
CG10834 37
  • 39 (a)
OneToMany
robl 37
  • 72 (a)
OneToMany
robl22E 37
  • 53 (a)
OneToMany
robls54B 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyrb-1 36
  • 57.71 (n)
  • 49.46 (a)
dyrb-1 37
  • 47 (a)
OneToOne
Species with no ortholog for DYNLRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNLRB1 Gene

ENSEMBL:
Gene Tree for DYNLRB1 (if available)
TreeFam:
Gene Tree for DYNLRB1 (if available)

Paralogs for DYNLRB1 Gene

Paralogs for DYNLRB1 Gene

Selected SIMAP similar genes for DYNLRB1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DYNLRB1 Gene

genes like me logo Genes that share paralogs with DYNLRB1: view

Variants for DYNLRB1 Gene

Sequence variations from dbSNP and Humsavar for DYNLRB1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs10036 - 34,534,759(-) GCGAA(A/T)TCGAA reference, missense, nc-transcript-variant
rs10322 -- 34,540,864(-) GCTTC(A/C)TGCAA utr-variant-3-prime, nc-transcript-variant
rs1063616 - 34,526,303(+) CAGAG(A/C)CAGAA utr-variant-5-prime, missense, reference, nc-transcript-variant
rs1122174 -- 34,523,041(-) CGTTC(A/G)TCTCC intron-variant
rs1998408 -- 34,530,445(+) AGAAT(A/G)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLRB1 Gene

Variant ID Type Subtype PubMed ID
nsv912858 CNV Loss 21882294
esv2348050 CNV Deletion 18987734
esv4648 CNV Deletion 18987735
esv2722355 CNV Deletion 23290073
esv2660231 CNV Deletion 23128226
esv1002762 CNV Deletion 20482838
esv1132908 CNV Deletion 17803354
nsv179054 CNV Loss 16902084
nsv3359 CNV Loss 18451855

Relevant External Links for DYNLRB1 Gene

HapMap Linkage Disequilibrium report
DYNLRB1

Disorders for DYNLRB1 Gene

(1) University of Copenhagen DISEASES for DYNLRB1 Gene

genes like me logo Genes that share disorders with DYNLRB1: view

No data available for UniProtKB/Swiss-Prot for DYNLRB1 Gene

Publications for DYNLRB1 Gene

  1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PMID: 11750132) Jiang J. … Zhao S. (Gene 2001) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  4. Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74. (PMID: 16970917) Liu J.F. … Liang D.C. (Biochem. Biophys. Res. Commun. 2006) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4

Products for DYNLRB1 Gene

Sources for DYNLRB1 Gene

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