Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DYNLRB1 Gene

protein-coding   GIFtS: 58
GCID: GC20P033104

Dynein, Light Chain, Roadblock-Type 1

(Previous names: dynein, cytoplasmic, light polypeptide 2A)
(Previous symbol: DNCL2A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dynein, Light Chain, Roadblock-Type 11 2     BITH2 3
DNCL2A1 2 3 5     BLP2 3
DNLC2A2 3 5     ROBLD12 3
Dynein, Cytoplasmic, Light Polypeptide 2A1 2     Roadblock Domain Containing 11
Bithoraxoid-Like Protein2 3     Dynein Light Chain Roadblock-Type 12
Dynein-Associated Protein Km232 3     ROBL/LC7-Like 12
Roadblock Domain-Containing Protein 12 3     Dynein Light Chain 2A, Cytoplasmic3

External Ids:    HGNC: 154681   Entrez Gene: 836582   Ensembl: ENSG000001259717   OMIM: 6071675   UniProtKB: Q9NP973   

Export aliases for DYNLRB1 gene to outside databases

Previous GC identifers: GC20P032568 GC20P029885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DYNLRB1 Gene:
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of
binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in
the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular
carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in
multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. (provided by
RefSeq, Aug 2013)

GeneCards Summary for DYNLRB1 Gene:
DYNLRB1 (dynein, light chain, roadblock-type 1) is a protein-coding gene. Diseases associated with DYNLRB1 include blastomycosis, and carrion's disease. GO annotations related to this gene include microtubule motor activity and identical protein binding. An important paralog of this gene is DYNLRB2.

UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules

Gene Wiki entry for DYNLRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNLRB1 gene promoter:
         AML1a   Pax-6   IRF-1   Cdc5   RORalpha2   MEF-2A   SEF-1 (1)   aMEF-2   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNLRB1 promoter sequence
   Search Chromatin IP Primers for DYNLRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNLRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.21

DYNLRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLRB1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033104:  view genomic region     (about GC identifiers)

Start:
33,104,204 bp from pter      End:
33,128,762 bp from pter
Size:
24,559 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97 (See protein sequence)
Recommended Name: Dynein light chain roadblock-type 1  
Size: 96 amino acids; 10922 Da
Subunit: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of
non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains
(LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer
serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and
LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNLRB2.
Interacts with DYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct.
Interacts with RAB6A isoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound)
4 PDB 3D structures from and Proteopedia for DYNLRB1:
1Z09 (3D)        2B95 (3D)        2E8J (3D)        2HZ5 (3D)    
Secondary accessions: B1AKR5 Q5TC72 Q96IV3 Q9NQM2
Alternative splicing: 2 isoforms:  Q9NP97-1   Q9NP97-2   (May result from the retention of an intron in the cDNA)

Explore the universe of human proteins at neXtProt for DYNLRB1: NX_Q9NP97

Explore proteomics data for DYNLRB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9, Lys15, Lys31, Lys52, Lys84
  • Modification sites at PhosphoSitePlus

  • See DYNLRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001268656.1  NP_001268657.1  NP_001268658.1  NP_054902.1  NP_808852.1  

    ENSEMBL proteins: 
     ENSP00000349679   ENSP00000300469   ENSP00000363979   ENSP00000409090  

    DYNLRB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DYNLRB1
    OriGene Protein Over-expression Lysate for DYNLRB1
    OriGene MassSpec for DYNLRB1
    OriGene Custom Protein Services for DYNLRB1
    GenScript Custom Purified and Recombinant Proteins Services for DYNLRB1
    Novus Biologicals DYNLRB1 Proteins
    Novus Biologicals DYNLRB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DYNLRB1
    Cloud-Clone Corp. Proteins for DYNLRB1

    DYNLRB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DYNLRB1
    Abcam antibodies for DYNLRB1
    Cloud-Clone Corp. Antibodies for DYNLRB1
    Search ThermoFisher Antibodies for DYNLRB1
    LSBio Antibodies in human, mouse, rat for DYNLRB1

    DYNLRB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DYNLRB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DYNLRB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DYNLRB1
    Cloud-Clone Corp. CLIAs for DYNLRB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    2 InterPro protein domains:
     IPR016561 Dynein_light_roadblock-type
     IPR004942 Dynein_light-rel

    Graphical View of Domain Structure for InterPro Entry Q9NP97

    ProtoNet protein and cluster: Q9NP97

    1 Blocks protein domain: IPB004942 Roadblock/LC7 family

    UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97
    Similarity: Belongs to the GAMAD family


    DYNLRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DLRB1_HUMAN, Q9NP97
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity NAS11750132
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--
         
    DYNLRB1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DYNLRB1:
     Increased 8N DNA content  Increased number of mitotic ce  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dynlrb1):
     mortality/aging 

    DYNLRB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYNLRB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DYNLRB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DYNLRB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DYNLRB1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DYNLRB1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DYNLRB1:
    hsa-miR-186 hsa-miR-1252 hsa-miR-3133 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidDYNLRB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DYNLRB1
    Predesigned siRNA for gene silencing in human, mouse, rat DYNLRB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DYNLRB1

    Clone
    Products:
         
    OriGene clones in human, mouse for DYNLRB1 (see all 7)
    OriGene ORF clones in mouse, rat for DYNLRB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DYNLRB1 (NM_014183)
    Sino Biological Human cDNA Clone for DYNLRB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYNLRB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLRB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DYNLRB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DYNLRB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLRB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DLRB1_HUMAN, Q9NP97: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005813centrosome IDA--
    GO:0005868cytoplasmic dynein complex NAS11750132
    GO:0005874microtubule IEA--

    DYNLRB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DYNLRB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    3TGF-beta receptor signaling
    TGF-beta receptor signaling
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DYNLRB1
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF

    1 BioSystems Pathway for DYNLRB1
        TGF-beta receptor signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYNLRB1
    Interactions:

        Search GeneGlobe Interaction Network for DYNLRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNLRB1 (Q9NP972, 3 ENSP000003496794) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNC1I1O145763, ENSP000003201304I2D: score=3 STRING: ENSP00000320130
    MPP6Q9NZW53, ENSP000002226444I2D: score=2 STRING: ENSP00000222644
    BCL2L1Q078173, ENSP000003025644I2D: score=1 STRING: ENSP00000302564
    CPEB1Q9BZB83, ENSP000004141874I2D: score=1 STRING: ENSP00000414187
    HSPH1Q925983, ENSP000003186874I2D: score=1 STRING: ENSP00000318687
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007018microtubule-based movement NAS11750132
    GO:0007632visual behavior ISS--
    GO:0008152metabolic process NAS11750132

    DYNLRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYNLRB1 (DLRB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DYNLRB1 gene (5 alternative transcripts): 
    NM_001281727.1  NM_001281728.1  NM_001281729.1  NM_014183.3  NM_177953.2  

    Unigene Cluster for DYNLRB1:

    Dynein, light chain, roadblock-type 1
    Hs.593920  [show with all ESTs]
    Unigene Representative Sequence: AK097281
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357156(uc002xal.3) ENST00000480759 ENST00000300469(uc002xao.3)
    ENST00000374846 ENST00000417166(uc010zuk.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DYNLRB1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DYNLRB1:
    hsa-miR-186 hsa-miR-1252 hsa-miR-3133 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidDYNLRB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DYNLRB1
    Predesigned siRNA for gene silencing in human, mouse, rat DYNLRB1
    Clone
    Products:
         
    OriGene clones in human, mouse for DYNLRB1 (see all 7)
    OriGene ORF clones in mouse, rat for DYNLRB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DYNLRB1 (NM_014183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYNLRB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLRB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DYNLRB1
    OriGene qSTAR qPCR primer pairs in human, mouse for DYNLRB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYNLRB1
      QuantiTect SYBR Green Assays in human, mouse, rat DYNLRB1
      QuantiFast Probe-based Assays in human, mouse, rat DYNLRB1

    Additional mRNA sequence: 

    AF132750.1 AF161511.1 AF165516.1 AF178431.1 AK026864.1 AK097281.1 AK294214.1 AY026513.1 
    BC002481.1 BC007223.2 

    21 DOTS entries:

    DT.100038015  DT.452007  DT.100795433  DT.95369365  DT.100795437  DT.92453938  DT.40240199  DT.403148 
    DT.92453929  DT.95369369  DT.100795431  DT.120810789  DT.95369367  DT.100038013  DT.100795435  DT.40316790 
    DT.87016853  DT.95361597  DT.95369368  DT.95369371  DT.91941391 

    Selected AceView cDNA sequences (see all 670):

    BQ630963 BQ422558 AL550321 CB110920 BU619291 BP346785 CB122253 AI053491 
    CB070339 BQ576012 BQ288011 BQ917395 NM_014183 BG282750 BU726828 CA416542 
    BG029888 BU726444 AW157204 CB147656 AA169876 BX280215 T95290 BX335331 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -                 -     -     -     -           -                                 
    SP2:                          -                 -     -     -     -           -                                 
    SP3:                          -     -           -     -     -                 -                                 
    SP4:                          -     -           -     -     -     -           -                                 
    SP5:                          -     -           -     -     -     -           -                                 


    ECgene alternative splicing isoforms for DYNLRB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DYNLRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGTCGCTT
    DYNLRB1 Expression
    About this image


    DYNLRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    DYNLRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNLRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.593920

    UniProtKB/Swiss-Prot: DLRB1_HUMAN, Q9NP97
    Tissue specificity: High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and
    kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64%
    hepatocellular carcinoma (HCC) patients

        Custom PCR Arrays for DYNLRB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DYNLRB1
    OriGene qSTAR qPCR primer pairs in human, mouse for DYNLRB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYNLRB1
    QuantiTect SYBR Green Assays in human, mouse, rat DYNLRB1
    QuantiFast Probe-based Assays in human, mouse, rat DYNLRB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DYNLRB1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dynlrb11 , 5 dynein light chain roadblock-type 11, 5 91.32(n)1
    96.87(a)1
      2 (77.07 cM)5
    670681  NM_025947.31  NP_080223.21 
     1552365335 
    chicken
    (Gallus gallus)
    Aves DYNLRB11 dynein, light chain, roadblock-type 1 84.03(n)
    93.75(a)
      419143  XM_417328.4  XP_417328.3 
    lizard
    (Anolis carolinensis)
    Reptilia DYNLRB16
    dynein, light chain, roadblock-type 1
    90(a)
    1 ↔ 1
    4(138172348-138180996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dynlrb11 dynein, light chain, roadblock-type 1 78.47(n)
    83.33(a)
      100101695  NM_001100217.1  NP_001093687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563352 similar to dynein, cytoplasmic, light polypeptide 2A 76.85(n)   394163  BC046084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta robl6
    robl22E6
    (see all 5)
    robl22E
    (see all 5)
    72(a)
    53(a)
    (see all 5)
    many → 1
    many → 1
    (see all 5)
    2R(13343979-13344634)
    2L(2290224-2290738)
    worm
    (Caenorhabditis elegans)
    Secernentea dyrb-11 dyrb-1 57.71(n)
    49.46(a)
      188872  NM_063542.4  NP_495943.1 


    ENSEMBL Gene Tree for DYNLRB1 (if available)
    TreeFam Gene Tree for DYNLRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DYNLRB1 gene
    DYNLRB22  
    1 SIMAP similar gene for DYNLRB1 using alignment to 3 protein entries:     DLRB1_HUMAN (see all proteins):
    DYNLRB2

    DYNLRB1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DYNLRB1
    PGOHUM00000239630 PGOHUM00000234942


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DYNLRB1 (see all 474)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168433181,2
    C,F--33102252(+) CCATTC/TTCTTT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1450743011,2
    --33102306(+) TCAGTC/GTGGTT 1 -- us2k10--------
    rs1175693261,2
    C,F--33102431(+) TTCAAT/CAGAAA 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1468226241,2
    --33102683(+) TTACTA/CCTCTA 1 -- us2k10--------
    rs1167407701,2
    C,F--33102774(+) TAGAAC/TATCCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs60885141,2
    C,F,A,H--33102835(+) gtggaA/Gaatga 1 -- us2k19Minor allele frequency- G:0.03NS NA 824
    rs1841544661,2
    --33103202(+) ACGGCA/GGCATG 1 -- us2k10--------
    rs81154491,2
    C,F,H--33103215(+) TTAACA/GGAAGT 1 -- us2k1 tfbs39Minor allele frequency- G:0.01NS EA NA 924
    rs1501425011,2
    C--33103326(+) AACACA/GCAGAT 1 -- us2k10--------
    rs725476281,2
    C--33103447(+) AGACY-/CAMSAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYNLRB1 (33104204 - 33128762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DYNLRB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002762CNV Deletion20482838
    esv1132908CNV Deletion17803354
    esv4648CNV Deletion18987735
    esv2348050CNV Deletion18987734
    esv2660231CNV Deletion23128226
    esv2722355CNV Deletion23290073
    nsv3359CNV Loss18451855
    nsv912858CNV Loss21882294
    nsv179054CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYNLRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNLRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607167    OMIM disorders: --

    10 diseases for DYNLRB1:    
    About MalaCards
    blastomycosis    carrion's disease    bronchopulmonary dysplasia    hepatocellular carcinoma
    breast and colorectal cancer    influenza    hypoxia    colorectal cancer
    squamous cell carcinoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DYNLRB1:
    Carrion's Disease

    DYNLRB1 for disorders           About GeneDecksing


    Export disorders for DYNLRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DYNLRB1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with DYNLRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PubMed id 11750132)1, 2, 3, 9 Jiang J.... Zhao S. (Gene 2001)
    2. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. (PubMed id 18044744)1, 2 Wanschers B.F.J.... Fransen J. (Cell Motil. Cytoskeleton 2008)
    3. Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74. (PubMed id 16970917)1, 2 Liu J.F....Liang D.C. (Biochem. Biophys. Res. Commun. 2006)
    4. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (J. Cell Biol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain. (PubMed id 12077152)1, 2 Susalka S.J.... Pfister K.K. (J. Biol. Chem. 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    10. Requirement for protein kinase A in the phosphorylation of the TGFI^ receptor-interacting protein km23-1 as a component of TGFI^ downstream effects. (PubMed id 23333499)1 Jin Q....Mulder K.M. (Exp. Cell Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83658 HGNC: 15468 AceView: DNCL2A Ensembl:ENSG00000125971 euGenes: HUgn83658
    ECgene: DYNLRB1 H-InvDB: DYNLRB1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DYNLRB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DYNLRB1 gene:
    Search GeneIP for patents involving DYNLRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DYNLRB1  
     OriGene qPCR primer pairs and template standards for DYNLRB1   OriGene Protein Over-expression Lysate for DYNLRB1  
     OriGene MassSpec something-or-other for DYNLRB1   OriGene clones in human, mouse for DYNLRB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DYNLRB1   OriGene Purified Protein for DYNLRB1  
     OriGene ORF clones in mouse, rat for DYNLRB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DYNLRB1   OriGene Custom Protein Services for DYNLRB1  

     
     
     Block miRNA regulation of human, mouse, rat DYNLRB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DYNLRB1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNLRB1 Predesigned siRNA for gene silencing in human, mouse, rat DYNLRB1
     QuantiFast Probe-based Assays in human, mouse, rat DYNLRB1 QuantiTect SYBR Green Assays in human, mouse, rat DYNLRB1
     Custom PCR Arrays for DYNLRB1 Search Chromatin IP Primers for DYNLRB1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYNLRB1  Search GeneGlobe Interaction Network for DYNLRB1
     Regulatory tfbs in DYNLRB1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DYNLRB1 GenScript cDNA clones with any tag delivered in your preferred vector for DYNLRB1
     GenScript Custom Assay Services for DYNLRB1 GenScript Custom overexpressing Cell Line Services for DYNLRB1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DYNLRB1 (DLRB1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DYNLRB1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DYNLRB1 proteins
     DYNLRB1 lysates
     Antibodies for DYNLRB1
     See all of Abcam's Antibodies, Kits and Proteins for DYNLRB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DYNLRB1
     Proteins for DYNLRB1
     Antibodies for DYNLRB1
     ELISAs for DYNLRB1
     CLIAs for DYNLRB1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DYNLRB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLRB1
     SwitchGear 3'UTR luciferase reporter plasmids for DYNLRB1
     SwitchGear Promoter luciferase reporter plasmids for DYNLRB1
     Search ThermoFisher Antibodies for DYNLRB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLRB1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYNLRB1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DYNLRB1
     LSBio Antibodies in human, mouse, rat for DYNLRB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DYNLRB1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4