Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DYNLRB1 Gene

Aliases for DYNLRB1 Gene

  • Dynein Light Chain Roadblock-Type 1 2 3
  • Dynein, Cytoplasmic, Light Polypeptide 2A 2 3
  • Roadblock Domain-Containing Protein 1 3 4
  • Dynein, Light Chain, Roadblock-Type 1 3 5
  • Dynein-Associated Protein Km23 3 4
  • Bithoraxoid-Like Protein 3 4
  • DNCL2A 3 4
  • DNLC2A 3 4
  • ROBLD1 3 4
  • BITH 3 4
  • BLP 3 4
  • Dynein Light Chain 2A, Cytoplasmic 4
  • Roadblock Domain Containing 1 2
  • ROBL/LC7-Like 1 3

External Ids for DYNLRB1 Gene

Previous HGNC Symbols for DYNLRB1 Gene

  • DNCL2A

Previous GeneCards Identifiers for DYNLRB1 Gene

  • GC20P032568
  • GC20P033104
  • GC20P029885

Summaries for DYNLRB1 Gene

Entrez Gene Summary for DYNLRB1 Gene

  • This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

GeneCards Summary for DYNLRB1 Gene

DYNLRB1 (Dynein Light Chain Roadblock-Type 1) is a Protein Coding gene. Diseases associated with DYNLRB1 include carrion's disease and brain germinoma. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Organelle biogenesis and maintenance. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNLRB2.

UniProtKB/Swiss-Prot for DYNLRB1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Gene Wiki entry for DYNLRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLRB1 Gene

Genomics for DYNLRB1 Gene

Regulatory Elements for DYNLRB1 Gene

Promoters for DYNLRB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DYNLRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DYNLRB1 Gene

Chromosome:
20
Start:
34,516,355 bp from pter
End:
34,540,958 bp from pter
Size:
24,604 bases
Orientation:
Plus strand

Genomic View for DYNLRB1 Gene

Genes around DYNLRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLRB1 Gene

Proteins for DYNLRB1 Gene

  • Protein details for DYNLRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP97-DLRB1_HUMAN
    Recommended name:
    Dynein light chain roadblock-type 1
    Protein Accession:
    Q9NP97
    Secondary Accessions:
    • B1AKR5
    • Q5TC72
    • Q96IV3
    • Q9NQM2

    Protein attributes for DYNLRB1 Gene

    Size:
    96 amino acids
    Molecular mass:
    10922 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNLRB2. Interacts with DYNC1I1 and DYNC1I2. Interacts with RAB6A isoform 1 (GTP-bound); the interaction is direct. Interacts with RAB6A isoform 2 (GDP-bound); the interaction is direct. Interacts with RAB6B (GDP-bound).

    Three dimensional structures from OCA and Proteopedia for DYNLRB1 Gene

    Alternative splice isoforms for DYNLRB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNLRB1 Gene

Proteomics data for DYNLRB1 Gene at MOPED

Post-translational modifications for DYNLRB1 Gene

  • Ubiquitination at Lys 15, Lys 31, Lys 52, and Lys 84
  • Modification sites at PhosphoSitePlus

Other Protein References for DYNLRB1 Gene

No data available for DME Specific Peptides for DYNLRB1 Gene

Domains & Families for DYNLRB1 Gene

Gene Families for DYNLRB1 Gene

Protein Domains for DYNLRB1 Gene

Suggested Antigen Peptide Sequences for DYNLRB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP97

UniProtKB/Swiss-Prot:

DLRB1_HUMAN :
  • Belongs to the GAMAD family.
Family:
  • Belongs to the GAMAD family.
genes like me logo Genes that share domains with DYNLRB1: view

Function for DYNLRB1 Gene

Molecular function for DYNLRB1 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

Gene Ontology (GO) - Molecular Function for DYNLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DYNLRB1: view
genes like me logo Genes that share phenotypes with DYNLRB1: view

Animal Models for DYNLRB1 Gene

MGI Knock Outs for DYNLRB1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DYNLRB1 Gene

Localization for DYNLRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLRB1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLRB1 Gene COMPARTMENTS Subcellular localization image for DYNLRB1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DYNLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005868 cytoplasmic dynein complex NAS 11750132
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with DYNLRB1: view

Pathways & Interactions for DYNLRB1 Gene

genes like me logo Genes that share pathways with DYNLRB1: view

Pathways by source for DYNLRB1 Gene

SIGNOR curated interactions for DYNLRB1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DYNLRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DYNLRB1: view

Drugs & Compounds for DYNLRB1 Gene

No Compound Related Data Available

Transcripts for DYNLRB1 Gene

Unigene Clusters for DYNLRB1 Gene

Dynein, light chain, roadblock-type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLRB1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for DYNLRB1 Gene

GeneLoc Exon Structure for
DYNLRB1
ECgene alternative splicing isoforms for
DYNLRB1

Expression for DYNLRB1 Gene

mRNA expression in normal human tissues for DYNLRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DYNLRB1 Gene

This gene is overexpressed in Amniocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLRB1 Gene



SOURCE GeneReport for Unigene cluster for DYNLRB1 Gene Hs.593920

mRNA Expression by UniProt/SwissProt for DYNLRB1 Gene

Q9NP97-DLRB1_HUMAN
Tissue specificity: High expression in heart, liver, brain and pancreas; moderate in placenta, skeletal muscle and kidney; low in lung, prostate, testis, small intestine and colon. Isoform 1 expression is up-regulated in 64% hepatocellular carcinoma (HCC) patients.
genes like me logo Genes that share expression patterns with DYNLRB1: view

Protein tissue co-expression partners for DYNLRB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DYNLRB1 Gene

Orthologs for DYNLRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNLRB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DYNLRB1 35
  • 93.4 (n)
  • 96.87 (a)
DYNLRB1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLRB1 35
  • 94.1 (n)
  • 96.87 (a)
DYNLRB1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynlrb1 35
  • 91.32 (n)
  • 96.87 (a)
Dynlrb1 16
Dynlrb1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYNLRB1 35
  • 100 (n)
  • 100 (a)
DYNLRB1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynlrb1 35
  • 90.97 (n)
  • 96.87 (a)
oppossum
(Monodelphis domestica)
Mammalia DYNLRB1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNLRB1 35
  • 84.03 (n)
  • 93.75 (a)
DYNLRB1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLRB1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynlrb1 35
  • 78.47 (n)
  • 83.33 (a)
zebrafish
(Danio rerio)
Actinopterygii dynlrb1 35
  • 74.31 (n)
  • 80.21 (a)
zgc56335 35
dynlrb1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10822 36
  • 26 (a)
OneToMany
CG10834 36
  • 39 (a)
OneToMany
robl 36
  • 72 (a)
OneToMany
robl22E 36
  • 53 (a)
OneToMany
robls54B 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyrb-1 35
  • 57.71 (n)
  • 49.46 (a)
dyrb-1 36
  • 47 (a)
OneToOne
Species with no ortholog for DYNLRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNLRB1 Gene

ENSEMBL:
Gene Tree for DYNLRB1 (if available)
TreeFam:
Gene Tree for DYNLRB1 (if available)

Paralogs for DYNLRB1 Gene

Paralogs for DYNLRB1 Gene

(1) SIMAP similar genes for DYNLRB1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DYNLRB1 Gene

genes like me logo Genes that share paralogs with DYNLRB1: view

Variants for DYNLRB1 Gene

Sequence variations from dbSNP and Humsavar for DYNLRB1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1063616 - 34,526,303(+) CAGAG(A/C)CAGAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10036 - 34,534,759(-) GCGAA(A/T)TCGAA nc-transcript-variant, reference, missense
rs10322 -- 34,540,864(-) GCTTC(A/C)TGCAA nc-transcript-variant, utr-variant-3-prime
rs2378205 -- 34,522,998(+) CTGGT(C/G)TGGTT intron-variant
rs1122174 -- 34,523,041(-) CGTTC(A/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLRB1 Gene

Variant ID Type Subtype PubMed ID
nsv912858 CNV Loss 21882294
esv2348050 CNV Deletion 18987734
esv4648 CNV Deletion 18987735
esv2722355 CNV Deletion 23290073
esv2660231 CNV Deletion 23128226
esv1002762 CNV Deletion 20482838
esv1132908 CNV Deletion 17803354
nsv179054 CNV Loss 16902084
nsv3359 CNV Loss 18451855

Variation tolerance for DYNLRB1 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNLRB1 Gene

HapMap Linkage Disequilibrium report
DYNLRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLRB1 Gene

Disorders for DYNLRB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DYNLRB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carrion's disease
  • carrion disease
brain germinoma
  • germinoma of the brain
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DYNLRB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNLRB1
genes like me logo Genes that share disorders with DYNLRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLRB1 Gene

Publications for DYNLRB1 Gene

  1. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. (PMID: 11750132) Jiang J. … Zhao S. (Gene 2001) 2 3 4 23 67
  2. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Requirement for protein kinase A in the phosphorylation of the TGFI^ receptor-interacting protein km23-1 as a component of TGFI^ downstream effects. (PMID: 23333499) Jin Q. … Mulder K.M. (Exp. Cell Res. 2013) 3
  5. Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells. (PMID: 23755307) Jin Q. … Mulder K.M. (PLoS ONE 2013) 3

Products for DYNLRB1 Gene

Sources for DYNLRB1 Gene

Back to Top

Content