DYNLL2 Gene
protein-coding GIFtS: 59
GCID: GC17P056160
|
|
dynein, light chain, LC8-type 2
| |
Aliases
for DYNLL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dynein, Light Chain, LC8-Type 21 2 | | DLC23 5 | | DNCL1B1 2 | | MGC178101 | | Dlc21 2 | | Dynein Light Chain 2, Cytoplasmic2 | | RSPH221 2 | | Radial Spoke 22 Homolog2 | | 8 KDa Dynein Light Chain B2 3 | | Dynein Light Chain LC8-Type 23 | | DLC8b2 3 | | |
Export aliases for DYNLL2 gene to outside databasesPrevious GC identifers: GC17P053516 GC17P051521 |
Summaries
for DYNLL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Mayplay a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)
Gene Wiki entry for DYNLL2
|
Genomic Views
for DYNLL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYNLL2 gene promoter:
STAT1 LHX3b/Lhx3b AML1a NRSF form 1 Lmo2 NF-kappaB NRSF form 2 MZF-1 LHX3a/Lhx3a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYNLL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.2DYNLL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P056160: view genomic region
(about GC identifiers)
Start:
|
56,160,776 bp from pter |
End:
|
56,168,592 bp from pter |
Size:
|
7,817 bases |
Orientation:
|
plus strand |
|
Proteins
for DYNLL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2 (See
protein sequence)Recommended Name: Dynein light chain 2, cytoplasmic Size: 89 amino acids; 10350 Da
Subunit: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number ofnon-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains(LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves asa scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs binddirectly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Componentof the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
2 PDB 3D structures from  and Proteopedia  for DYNLL2:2XQQ (3D)
3P8M (3D)
Secondary accessions: B2R5B4Explore the universe of human proteins at neXtProt for DYNLL2: NX_Q96FJ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96FJ2
DYNLL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542408.1
ENSEMBL proteins: ENSP00000240343 Reactome Protein details: Q96FJ2
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
DYNLL2 for ontologies About GeneDecksing
DYNLL2 Antibody Products:
Assay Products for DYNLL2: |
Protein
Domains /
Families
for DYNLL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYNLL2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96FJ2ProtoNet protein and cluster: Q96FJ2 1 Blocks protein family: IPB001372 Dynein light chain
UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2Similarity: Belongs to the dynein light chain family |
Function
for DYNLL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Mayplay a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DYNLL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DYNLL2:
|
Pathways & Interactions
for DYNLL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell cycle_Spindle assembly and chromosome separation | | | 2 | Immune System | | | 3 | MHC class II antigen presentation | | | 4 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | | | 5 | Activation of BMF and translocation to mitochondria | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DYNLL2
2  GeneGo (Thomson Reuters) Pathways for DYNLL2
5/8 
Reactome Pathways for DYNLL2 (see all 8)
1 
Kegg Pathway (Kegg details for DYNLL2):
DYNLL2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNLL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/95 Interacting proteins for DYNLL2 (Q96FJ22, 3 ENSP000002403434) via UniProtKB, MINT, STRING, and/or I2D (see all 95)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
DYNLL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DYNLL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DYNLL2
Search CenterWatch for drugs/clinical trials and news about DYNLL2 / DYL2
|
Transcripts
for DYNLL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DYNLL2 gene: NM_080677.2 Unigene Cluster for DYNLL2: Dynein, light chain, LC8-type 2 Hs.720595 [show with all ESTs]Unigene Representative Sequence: NM_0806771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000240343(uc010wnn.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DYNLL2 (NM_080677) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYNLL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL2 |
Additional cDNA sequence: AF086304.1 AF112997.1 AK312125.1 BC010744.1 4 DOTS entries: DT.111212 DT.95155421 DT.120996772 DT.87046862 24/36 AceView cDNA sequences (see all 36): AI201042 CD679355 AI992227 AF086304 AI719240 W69788 AW852307 AA353512 NM_080677 BG327828 BG482221 AA435992 BU731450 AI954150 BC010744 AA534422 W73755 BM708057 BG479903 BF528423 AA298041 AA399997 AI027684 BE875501
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|
|
| SP1: | | | - | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DYNLL2
|
Expression
for DYNLL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DYNLL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATGTCGC
About this image
See DYNLL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYNLL2
SOURCE GeneReport for Unigene cluster: Hs.720595
SABiosciences Custom PCR Arrays for DYNLL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYNLL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYNLL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL2 |
Orthologs
for DYNLL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DYNLL2 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DYNLL21 |
dynein, light chain, LC8-type 2 |
88.39(n)
100(a) |
|
417663 XM_415908.3 XP_415908.2 |
lizard
(Anolis carolinensis) |
Reptilia |
DYNLL26 |
-- |
100(a) |
1 ↔ 1 |
GL344172.1(41541-46532) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.87192 |
Xenopus laevis transcribed sequence with strong similarity more |
82.16(n) |
|
48034616 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC059707.12 |
-- |
84.48(n) |
|
BC059707.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
dlc-11 |
Protein DLC-1 |
82.4(n)
95.51(a) |
|
175922 NM_066021.3 NP_498422.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G159301 |
dynein light chain LC8-type |
67.83(n)
70.93(a) |
|
827275 NM_117685.6 NP_193328.4 |
rice
(Oryza sativa) |
Liliopsida |
AK107950.12 |
-- |
77.89(n) |
|
AK107950.1 |
ENSEMBL Gene Tree for DYNLL2 (if available)
TreeFam Gene Tree for DYNLL2 (if available) |
Paralogs
for DYNLL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DYNLL2 gene
- DNAL42 DYNLL12
4 SIMAP similar genes for DYNLL2 using alignment to 2 protein entries: DYL2_HUMAN (see all proteins):DNCL1 DYNLL1 LOC392067 DNAL4
DYNLL2 for paralogs About GeneDecksing
|
Genomic Variants
for DYNLL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DYNLL2 (56160776 - 56168592 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DYNLL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNLL2 |
|
Disorders
/ Diseases
for DYNLL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYNLL2 for disorders About GeneDecksing
OMIM gene information: 608942
OMIM disorders: --
5  diseases for DYNLL2: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia melanoma
neuronitis
Export disorders for DYNLL2 gene to outside databases
|
Publications
for DYNLL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DYNLL2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with DYNLL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PubMed id 14561217)1, 9 Day C.L....Hinds M.G. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Affinity, avidity, and kinetics of target sequence bi nding to LC8 dynein light chain isoforms. (PubMed id 20889982)1 Radnai L....Nyitray L. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for DYNLL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYNLL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYNLL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYNLL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DYNLL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DYNLL2 gene:
Search GeneIP for patents involving DYNLL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYNLL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL2 |
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