Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYNLL2 Gene

protein-coding   GIFtS: 59
GCID: GC17P056160

Dynein, Light Chain, LC8-Type 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dynein, Light Chain, LC8-Type 21 2     Dlc22
8 KDa Dynein Light Chain B2 3     RSPH222
DLC8b2 3     Dynein Light Chain 2, Cytoplasmic2
DLC23 5     Radial Spoke 22 Homolog2
Radial Spoke 22 Homolog (Chlamydomonas)1     Dynein Light Chain LC8-Type 23
DNCL1B2     

External Ids:    HGNC: 245961   Entrez Gene: 1407352   Ensembl: ENSG000001210837   OMIM: 6089425   UniProtKB: Q96FJ23   

Export aliases for DYNLL2 gene to outside databases

Previous GC identifers: GC17P053516 GC17P051521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DYNLL2 Gene: 
DYNLL2 (dynein, light chain, LC8-type 2) is a protein-coding gene. Diseases associated with DYNLL2 include chronic lymphocytic leukemia, and rabies, and among its related super-pathways are Activation of BH3-only proteins and Immune System. GO annotations related to this gene include cytoskeletal protein binding and motor activity. An important paralog of this gene is DNAL4.

UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By
similarity)

Gene Wiki entry for DYNLL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYNLL2 gene promoter:
         STAT1   LHX3b/Lhx3b   AML1a   NRSF form 1   Lmo2   NF-kappaB   NRSF form 2   MZF-1   LHX3a/Lhx3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNLL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYNLL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

DYNLL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLL2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P056160:  view genomic region     (about GC identifiers)

Start:
56,160,776 bp from pter      End:
56,168,592 bp from pter
Size:
7,817 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2 (See protein sequence)
Recommended Name: Dynein light chain 2, cytoplasmic  
Size: 89 amino acids; 10350 Da
Subunit: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of
non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains
(LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer
serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs
and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts
with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
2 PDB 3D structures from and Proteopedia for DYNLL2:
2XQQ (3D)        3P8M (3D)    
Secondary accessions: B2R5B4

Explore the universe of human proteins at neXtProt for DYNLL2: NX_Q96FJ2

Explore proteomics data for DYNLL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FJ2

  • DYNLL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DYNLL2 Protein Expression
    REFSEQ proteins: NP_542408.1  
    ENSEMBL proteins: 
     ENSP00000240343  
    Reactome Protein details: Q96FJ2
    Human Recombinant Protein Products for DYNLL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DYNLL2
    OriGene Protein Over-expression Lysate for DYNLL2
    OriGene MassSpec for DYNLL2 
    OriGene Custom Protein Services for DYNLL2
    GenScript Custom Purified and Recombinant Proteins Services for DYNLL2
    Novus Biologicals DYNLL2 Proteins
    Novus Biologicals DYNLL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DYNLL2
    Cloud-Clone Corp. Proteins for DYNLL2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex ----

    DYNLL2 for ontologies           About GeneDecksing



    DYNLL2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DYNLL2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DYNLL2
    GenScript Custom Superior Antibodies Services for DYNLL2
    Novus Biologicals DYNLL2 Antibodies
    Abcam antibodies for DYNLL2
    Cloud-Clone Corp. Antibodies for DYNLL2 
    Search ThermoFisher Antibodies for DYNLL2
    LSBio Antibodies in human, mouse, rat for DYNLL2 

    Assay Products for DYNLL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DYNLL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DYNLL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DYNLL2 
    Cloud-Clone Corp. CLIAs for DYNLL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DYN: Cytoplasmic dyneins

    2 InterPro protein domains:
     IPR019763 Dynein_light_1/2_CS
     IPR001372 Dynein_light_chain_typ-1/2

    Graphical View of Domain Structure for InterPro Entry Q96FJ2

    ProtoNet protein and cluster: Q96FJ2

    1 Blocks protein domain: IPB001372 Dynein light chain

    UniProtKB/Swiss-Prot: DYL2_HUMAN, Q96FJ2
    Similarity: Belongs to the dynein light chain family


    DYNLL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYL2_HUMAN, Q96FJ2
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding ----
    GO:0008092cytoskeletal protein binding IEA--
         
    DYNLL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DYNLL2:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DYNLL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DYNLL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DYNLL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DYNLL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYNLL2
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DYNLL2 (see all 48):
    hsa-miR-3685 hsa-miR-3938 hsa-miR-3194-5p hsa-miR-146a hsa-miR-938 hsa-miR-301a hsa-miR-639 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDYNLL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DYNLL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYNLL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DYNLL2
    Sirion Biotech Customized adenovirus for overexpression of DYNLL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DYNLL2 (see all 6)
    OriGene ORF clones in mouse, rat for DYNLL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DYNLL2 (NM_080677)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYNLL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL2
    Sirion Biotech Customized lentivirus for stable overexpression of DYNLL2 
                         Customized lentivirus expression plasmids for stable overexpression of DYNLL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DYNLL2
    Search LifeMap BioReagents cell lines for DYNLL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DYNLL2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Intrinsic Pathway for Apoptosis0.63
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94
    4Regulation of degradation of wt-CFTR
    Regulation of degradation of deltaF508 CFTR in CF0.59
    5CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DYNLL2
        Cell cycle Spindle assembly and chromosome separation
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DYNLL2
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF

    5/7        Reactome Pathways for DYNLL2 (see all 7)
        Activation of BH3-only proteins
    Activation of BMF and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Adaptive Immune System
    Apoptosis


    1         Kegg Pathway  (Kegg details for DYNLL2):
        Vasopressin-regulated water reabsorption


    DYNLL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNLL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for DYNLL2 (Q96FJ22, 3 ENSP000002403434) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAL4O960152, 3, ENSP000002160684MINT-66259 I2D: score=4 STRING: ENSP00000216068
    GPRIN2O602692, 3, ENSP000003634334MINT-67893 I2D: score=4 STRING: ENSP00000363433
    THAP10Q9P2Z02, 3, ENSP000002498614MINT-68009 I2D: score=4 STRING: ENSP00000249861
    HOMER3Q9NSC53, ENSP000003481504I2D: score=3 STRING: ENSP00000348150
    AMOTQ4VCS53, ENSP000003610274I2D: score=2 STRING: ENSP00000361027
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0006915apoptotic process TAS--
    GO:0007017microtubule-based process IEA--
    GO:0008039synaptic target recognition IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    DYNLL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DYNLL2 (DYL2)

    Search CenterWatch for drugs/clinical trials and news about DYNLL2 / DYL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DYNLL2 gene: 
    NM_080677.2  

    Unigene Cluster for DYNLL2:

    Dynein, light chain, LC8-type 2
    Hs.720595  [show with all ESTs]
    Unigene Representative Sequence: NM_080677
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000240343(uc010wnn.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYNLL2
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DYNLL2 (see all 48):
    hsa-miR-3685 hsa-miR-3938 hsa-miR-3194-5p hsa-miR-146a hsa-miR-938 hsa-miR-301a hsa-miR-639 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDYNLL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DYNLL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYNLL2
    Clone
    Products:
         
    OriGene clones in human, mouse for DYNLL2 (see all 6)
    OriGene ORF clones in mouse, rat for DYNLL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DYNLL2 (NM_080677)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYNLL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL2
    Sirion Biotech Customized lentivirus for stable overexpression of DYNLL2 
                         Customized lentivirus expression plasmids for stable overexpression of DYNLL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DYNLL2
    OriGene qSTAR qPCR primer pairs in human, mouse for DYNLL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYNLL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLL2

    Additional mRNA sequence: 

    AF086304.1 AF112997.1 AK312125.1 BC010744.1 

    4 DOTS entries:

    DT.111212  DT.95155421  DT.120996772  DT.87046862 

    24/36 AceView cDNA sequences (see all 36):

    AI201042 AI719240 AI992227 CD679355 AF086304 W69788 NM_080677 BG327828 
    BM708057 BF528423 BG482221 AA353512 BU731450 AA435992 AA534422 AI954150 
    W73755 AW852307 BC010744 BG479903 BM700738 AA298041 AA401429 AA889646 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:        -                           
    SP2:        -     -                     
    SP3:                                    


    ECgene alternative splicing isoforms for DYNLL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYNLL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATGTCGC
    DYNLL2 Expression
    About this image


    See DYNLL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYNLL2

    SOURCE GeneReport for Unigene cluster: Hs.720595
        SABiosciences Custom PCR Arrays for DYNLL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DYNLL2
    OriGene qSTAR qPCR primer pairs in human, mouse for DYNLL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYNLL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DYNLL2 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dynll21 , 5 dynein light chain LC8-type 21, 5 97.75(n)1
    100(a)1
      11 (52.35 cM)5
    680971  NM_001168471.11  NP_001161943.11 
     879795255 
    chicken
    (Gallus gallus)
    Aves DYNLL21 dynein, light chain, LC8-type 2 88.39(n)
    100(a)
      417663  XM_415908.3  XP_415908.2 
    lizard
    (Anolis carolinensis)
    Reptilia DYNLL26
    Uncharacterized protein
    100(a)
    1 ↔ 1
    GL344172.1(28066-46542)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87192 Xenopus laevis transcribed sequence with strong similarity more 82.16(n)    48034616 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059707.12   -- 84.48(n)    BC059707.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ctp6
    Cdlc26
    Cytoplasmic dynein light chain 2
    97(a)
    96(a)
    possible ortholog
    possible ortholog
    X(4581825-4596067)
    2L(1344480-1345144)
    worm
    (Caenorhabditis elegans)
    Secernentea dlc-11 Protein DLC-1 82.4(n)
    95.51(a)
      175922  NM_066021.3  NP_498422.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DYN26
    Cytoplasmic light chain dynein, microtubule motor ...
    47(a)
    1 → many
    IV(1319387-1319841)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G159301 dynein light chain LC8-type 67.83(n)
    70.93(a)
      827275  NM_117685.6  NP_193328.4 
    rice
    (Oryza sativa)
    Liliopsida AK107950.12   -- 77.89(n)    AK107950.1 


    ENSEMBL Gene Tree for DYNLL2 (if available)
    TreeFam Gene Tree for DYNLL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYNLL2 gene
    DNAL42  DYNLL12  
    4 SIMAP similar genes for DYNLL2 using alignment to 2 protein entries:     DYL2_HUMAN (see all proteins):
    DNCL1    DYNLL1    LOC392067    DNAL4

    DYNLL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/170 SNPs in DYNLL2 are shown (see all 170)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813409021,2
    C--56158842(+) CACAGA/CCTGGA 1 -- us2k10--------
    rs1476248761,2
    --56158873(+) TATTAC/TACTTC 1 -- us2k10--------
    rs1855837301,2
    --56158954(+) CATAGC/TAACCC 1 -- us2k10--------
    rs1424243111,2
    --56159019(+) CACACA/GGGCTA 1 -- us2k10--------
    rs1127299561,2
    C,F--56159224(+) ACAAGC/TCCTAA 1 -- us2k12Minor allele frequency- T:0.25CSA WA 120
    rs1164877591,2
    F--56159227(+) AGCCCT/GAAGTG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1479045161,2
    --56159233(+) AAGTGC/TATAAA 1 -- us2k10--------
    rs1489188111,2
    --56159251(+) TCCTCC/GTCTCC 1 -- us2k10--------
    rs1154544621,2
    C,F--56159260(+) CCCTCC/TCTTCC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1881038181,2
    --56159301(+) ACACAA/GAGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYNLL2 (56160776 - 56168592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DYNLL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833497CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DYNLL2
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNLL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608942    OMIM disorders: --

    5 diseases for DYNLL2:    About MalaCards
    chronic lymphocytic leukemia    rabies    melanoma    leukemia
    neuronitis


    DYNLL2 for disorders           About GeneDecksing


    Export disorders for DYNLL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYNLL2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with DYNLL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PubMed id 14561217)1, 9 Day C.L....Hinds M.G. (2004)
    4. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Viral immune modulators perturb the human molecular ne twork by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140735 HGNC: 24596 AceView: Dlc2 Ensembl:ENSG00000121083 euGenes: HUgn140735
    ECgene: DYNLL2 Kegg: 140735 H-InvDB: DYNLL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYNLL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DYNLL2 gene:
    Search GeneIP for patents involving DYNLL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of DYNLL2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DYNLL2  
     OriGene qPCR primer pairs and template standards for DYNLL2   OriGene Protein Over-expression Lysate for DYNLL2  
     OriGene MassSpec something-or-other for DYNLL2   OriGene clones in human, mouse for DYNLL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DYNLL2   OriGene Purified Protein for DYNLL2  
     OriGene ORF clones in mouse, rat for DYNLL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DYNLL2   OriGene Custom Protein Services for DYNLL2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYNLL2
     QIAGEN SeqTarget long-range PCR primers for resequencing DYNLL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYNLL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLL2
     GenScript Custom Purified and Recombinant Proteins Services for DYNLL2 GenScript cDNA clones with any tag delivered in your preferred vector for DYNLL2
     GenScript Custom Assay Services for DYNLL2 GenScript Custom Superior Antibodies Services for DYNLL2
     GenScript Custom overexpressing Cell Line Services for DYNLL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DYNLL2 promoter
     Search Chromatin IP Primers for DYNLL2
     RT2 qPCR Primer Assay in human, mouse, rat DYNLL2
     Search GNC Networks for DYNLL2
     SABiosciences Custom PCR Arrays for DYNLL2
     Search Tocris compounds for DYNLL2 (DYL2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DYNLL2 antibodies
     DYNLL2 proteins
     DYNLL2 lysates
     Antibodies for DYNLL2
     See all of Abcam's Antibodies, Kits and Proteins for DYNLL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DYNLL2




     Proteins for DYNLL2
     Antibodies for DYNLL2
     ELISAs for DYNLL2
     CLIAs for DYNLL2
     Search LifeMap BioReagents cell lines for DYNLL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL2
     SwitchGear 3'UTR luciferase reporter plasmids for DYNLL2
     SwitchGear Promoter luciferase reporter plasmids for DYNLL2
     Search ThermoFisher Antibodies for DYNLL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DYNLL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DYNLL2
    Customized:
     lentivirus for stable overexpression of DYNLL2
     lentivirus expression plasmids for stable overexpression of DYNLL2
     adenovirus for overexpression of DYNLL2
     LSBio Antibodies in human, mouse, rat for DYNLL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DYNLL2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4