Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DYNLL2 Gene

Aliases for DYNLL2 Gene

  • Dynein, Light Chain, LC8-Type 2 2 3
  • Dlc2 3 4 6
  • 8 KDa Dynein Light Chain B 3 4
  • DLC8b 3 4
  • Radial Spoke 22 Homolog (Chlamydomonas) 2
  • Dynein Light Chain 2, Cytoplasmic 3
  • Dynein Light Chain LC8-Type 2 4
  • Radial Spoke 22 Homolog 3
  • DNCL1B 3
  • RSPH22 3

External Ids for DYNLL2 Gene

Summaries for DYNLL2 Gene

GeneCards Summary for DYNLL2 Gene

DYNLL2 (Dynein, Light Chain, LC8-Type 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Vasopressin-regulated water reabsorption. GO annotations related to this gene include cytoskeletal protein binding and motor activity. An important paralog of this gene is DNAL4.

UniProtKB/Swiss-Prot for DYNLL2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Gene Wiki entry for DYNLL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLL2 Gene

Genomics for DYNLL2 Gene

Genomic Location for DYNLL2 Gene

Start:
58,083,415 bp from pter
End:
58,095,536 bp from pter
Size:
12,122 bases
Orientation:
Plus strand

Genomic View for DYNLL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL2 Gene

Regulatory Elements for DYNLL2 Gene

Proteins for DYNLL2 Gene

  • Protein details for DYNLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FJ2-DYL2_HUMAN
    Recommended name:
    Dynein light chain 2, cytoplasmic
    Protein Accession:
    Q96FJ2
    Secondary Accessions:
    • B2R5B4

    Protein attributes for DYNLL2 Gene

    Size:
    89 amino acids
    Molecular mass:
    10350 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity).

    Three dimensional structures from OCA and Proteopedia for DYNLL2 Gene

neXtProt entry for DYNLL2 Gene

Proteomics data for DYNLL2 Gene at MOPED

Post-translational modifications for DYNLL2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36 and Lys49

Other Protein References for DYNLL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DYNLL2 Gene

Domains for DYNLL2 Gene

Gene Families for DYNLL2 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNLL2 Gene

UniProtKB/Swiss-Prot:

DYL2_HUMAN
Family:
  • Belongs to the dynein light chain family.:
    • Q96FJ2
genes like me logo Genes that share domains with DYNLL2: view

Function for DYNLL2 Gene

Molecular function for DYNLL2 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Gene Ontology (GO) - Molecular Function for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with DYNLL2: view

Phenotypes for DYNLL2 Gene

GenomeRNAi human phenotypes for DYNLL2:
genes like me logo Genes that share phenotypes with DYNLL2: view

miRNA for DYNLL2 Gene

miRTarBase miRNAs that target DYNLL2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNLL2 Gene

Localization for DYNLL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLL2 Gene COMPARTMENTS Subcellular localization image for DYNLL2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with DYNLL2: view

Pathways for DYNLL2 Gene

genes like me logo Genes that share pathways with DYNLL2: view

Pathways by source for DYNLL2 Gene

Gene Ontology (GO) - Biological Process for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006915 apoptotic process TAS --
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process IEA --
GO:0008039 synaptic target recognition IEA --
genes like me logo Genes that share ontologies with DYNLL2: view

Transcripts for DYNLL2 Gene

mRNA/cDNA for DYNLL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DYNLL2 Gene

Dynein, light chain, LC8-type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL2 Gene

No ASD Table

Relevant External Links for DYNLL2 Gene

GeneLoc Exon Structure for
DYNLL2
ECgene alternative splicing isoforms for
DYNLL2

Expression for DYNLL2 Gene

mRNA expression in normal human tissues for DYNLL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DYNLL2 Gene

SOURCE GeneReport for Unigene cluster for DYNLL2 Gene Hs.720595

genes like me logo Genes that share expressions with DYNLL2: view

Orthologs for DYNLL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLL2 36
  • 100 (n)
  • 100 (a)
DYNLL2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNLL2 36
  • 96.63 (n)
  • 100 (a)
DYNLL2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNLL2 36
  • 97.38 (n)
  • 100 (a)
DYNLL2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynll2 36
  • 97.75 (n)
  • 100 (a)
Dynll2 16
Dynll2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNLL2 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL2 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynll2 36
  • 98.5 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves DYNLL2 36
  • 88.39 (n)
  • 100 (a)
DYNLL2 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLL2 37
  • 100 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8719 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dynll2 36
  • 86.14 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii dynll2a 37
  • 99 (a)
OneToMany
dynll2b 36
  • 83.52 (n)
  • 98.88 (a)
dynll2b 37
  • 99 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001335 36
  • 77.15 (n)
  • 95.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta ctp 36
  • 76.03 (n)
  • 96.63 (a)
worm
(Caenorhabditis elegans)
Secernentea dlc-1 36
  • 82.4 (n)
  • 95.51 (a)
dlc-1 37
  • 96 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 37
  • 47 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.10206 36
rice
(Oryza sativa)
Liliopsida Os01g0256400 36
  • 70.73 (n)
  • 68.29 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14337 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dlc2 36
  • 69.05 (n)
  • 77.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CS-DLC1 37
  • 96 (a)
OneToOne
Species with no ortholog for DYNLL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DYNLL2 Gene

ENSEMBL:
Gene Tree for DYNLL2 (if available)
TreeFam:
Gene Tree for DYNLL2 (if available)

Paralogs for DYNLL2 Gene

Paralogs for DYNLL2 Gene

Selected SIMAP similar genes for DYNLL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DYNLL2: view

Variants for DYNLL2 Gene

Sequence variations from dbSNP and Humsavar for DYNLL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9941389 -- 58,088,962(+) AGAGT(A/G)TCCTG intron-variant
rs16942650 -- 58,085,438(+) CCTGT(A/G)TAGCC intron-variant
rs16942657 -- 58,085,730(+) GGATA(A/T)GAAAC intron-variant
rs16942662 -- 58,089,138(+) CTTTT(C/T)TAGGA intron-variant
rs34661043 -- 58,085,546(+) GCTCC(-/C)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLL2 Gene

Variant ID Type Subtype PubMed ID
nsv833497 CNV Loss 17160897

Relevant External Links for DYNLL2 Gene

HapMap Linkage Disequilibrium report
DYNLL2

Disorders for DYNLL2 Gene

No disorders were found for DYNLL2 Gene.

No data available for UniProtKB/Swiss-Prot for DYNLL2 Gene

Publications for DYNLL2 Gene

  1. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  2. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PMID: 14561217) Day C.L. … Hinds M.G. (Biochem. J. 2004) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells. (PMID: 14574334) Morales A.A. … Osorio L.M. (Leukemia 2004) 23

Products for DYNLL2 Gene

Sources for DYNLL2 Gene

Back to Top

Content