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Aliases for DYNLL2 Gene

Aliases for DYNLL2 Gene

  • Dynein Light Chain LC8-Type 2 2 3 4 5
  • 8 KDa Dynein Light Chain B 3 4
  • DLC8b 3 4
  • Dlc2 3 4
  • Radial Spoke 22 Homolog (Chlamydomonas) 2
  • Dynein Light Chain 2, Cytoplasmic 3
  • Radial Spoke 22 Homolog 3
  • DNCL1B 3
  • RSPH22 3

External Ids for DYNLL2 Gene

Previous GeneCards Identifiers for DYNLL2 Gene

  • GC17P053516
  • GC17P056160
  • GC17P051521

Summaries for DYNLL2 Gene

GeneCards Summary for DYNLL2 Gene

DYNLL2 (Dynein Light Chain LC8-Type 2) is a Protein Coding gene. Among its related pathways are Activation of BH3-only proteins and Golgi-to-ER retrograde transport. GO annotations related to this gene include motor activity and cytoskeletal protein binding. An important paralog of this gene is DYNLL1.

UniProtKB/Swiss-Prot for DYNLL2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Gene Wiki entry for DYNLL2 Gene

Additional gene information for DYNLL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLL2 Gene

Genomics for DYNLL2 Gene

Regulatory Elements for DYNLL2 Gene

Enhancers for DYNLL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H057460 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -619.9 -619879 6 HDGF PKNOX1 ZNF493 ZFP64 ZBTB7B ZNF121 ZNF207 FOS ATF7 RUNX3 SRSF1 MKS1 ENSG00000262298 COIL DGKE MSI2 VEZF1 DYNLL2 ENSG00000279281 LOC101927557
GH17H057832 1.5 Ensembl ENCODE dbSUPER 10.3 -250.1 -250149 2 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZBTB7B ZNF207 ZNF143 FOS SRSF1 ENSG00000262298 CCDC182 MKS1 DYNLL2 AKAP1 CUEDC1 OR4D1 ENSG00000229590 ENSG00000265542
GH17H058387 1.3 ENCODE dbSUPER 9.8 +304.8 304800 1 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 ZNF207 FOS MKS1 SRSF1 RNF43 SUPT4H1 SKA2 HSF5 PPM1E LPO DYNLL2 TRIM37
GH17H058081 1.4 FANTOM5 ENCODE 7.3 +0.2 238 4 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 SRSF1 OR4D1 ENSG00000264914 SETP3 LOC101927557 TEX14 ENSG00000264112 CCDC182 VEZF1 LOC101927666
GH17H057834 0.9 ENCODE dbSUPER 10.3 -248.8 -248841 0 CTCF ESRRA ZNF687 NFIB SIN3A ELF1 DPF2 ZBTB7B ZKSCAN1 NONO SRSF1 ENSG00000262298 CCDC182 MKS1 DYNLL2 AKAP1 CUEDC1 OR4D1 ENSG00000229590 ENSG00000265542
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DYNLL2 on UCSC Golden Path with GeneCards custom track

Promoters for DYNLL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096223 685 1801 ATF1 FOXA2 ZFP64 ARID4B SIN3A ZBTB7B YY1 GLIS2 ZNF143 ZNF207

Genomic Location for DYNLL2 Gene

Chromosome:
17
Start:
58,083,415 bp from pter
End:
58,095,536 bp from pter
Size:
12,122 bases
Orientation:
Plus strand

Genomic View for DYNLL2 Gene

Genes around DYNLL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL2 Gene

Proteins for DYNLL2 Gene

  • Protein details for DYNLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FJ2-DYL2_HUMAN
    Recommended name:
    Dynein light chain 2, cytoplasmic
    Protein Accession:
    Q96FJ2
    Secondary Accessions:
    • B2R5B4

    Protein attributes for DYNLL2 Gene

    Size:
    89 amino acids
    Molecular mass:
    10350 Da
    Quaternary structure:
    • Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity).

    Three dimensional structures from OCA and Proteopedia for DYNLL2 Gene

neXtProt entry for DYNLL2 Gene

Post-translational modifications for DYNLL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNLL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DYNLL2
  • Santa Cruz Biotechnology (SCBT) Antibodies for DYNLL2

No data available for DME Specific Peptides for DYNLL2 Gene

Domains & Families for DYNLL2 Gene

Gene Families for DYNLL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DYNLL2 Gene

Suggested Antigen Peptide Sequences for DYNLL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FJ2

UniProtKB/Swiss-Prot:

DYL2_HUMAN :
  • Belongs to the dynein light chain family.
Family:
  • Belongs to the dynein light chain family.
genes like me logo Genes that share domains with DYNLL2: view

Function for DYNLL2 Gene

Molecular function for DYNLL2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity).

Phenotypes From GWAS Catalog for DYNLL2 Gene

Gene Ontology (GO) - Molecular Function for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008092 cytoskeletal protein binding IEA,IBA --
GO:0008574 contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA --
GO:0042803 protein homodimerization activity IEA --
GO:0045505 dynein intermediate chain binding IBA --
genes like me logo Genes that share ontologies with DYNLL2: view
genes like me logo Genes that share phenotypes with DYNLL2: view

Animal Model Products

CRISPR Products

miRNA for DYNLL2 Gene

miRTarBase miRNAs that target DYNLL2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DYNLL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNLL2 Gene

Localization for DYNLL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLL2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear bodies (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DYNLL2: view

Pathways & Interactions for DYNLL2 Gene

genes like me logo Genes that share pathways with DYNLL2: view

SIGNOR curated interactions for DYNLL2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DYNLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007017 microtubule-based process IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0008039 synaptic target recognition IEA --
genes like me logo Genes that share ontologies with DYNLL2: view

Drugs & Compounds for DYNLL2 Gene

No Compound Related Data Available

Transcripts for DYNLL2 Gene

mRNA/cDNA for DYNLL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DYNLL2 Gene

Dynein, light chain, LC8-type 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DYNLL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL2 Gene

No ASD Table

Relevant External Links for DYNLL2 Gene

GeneLoc Exon Structure for
DYNLL2
ECgene alternative splicing isoforms for
DYNLL2

Expression for DYNLL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYNLL2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DYNLL2 Gene



Protein tissue co-expression partners for DYNLL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DYNLL2 Gene:

DYNLL2

SOURCE GeneReport for Unigene cluster for DYNLL2 Gene:

Hs.720595

Evidence on tissue expression from TISSUES for DYNLL2 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(2.9)
  • Heart(2.5)
  • Kidney(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with DYNLL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLL2 Gene

Orthologs for DYNLL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLL2 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia DYNLL2 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL2 34
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynll2 33
  • 98.5 (n)
mouse
(Mus musculus)
Mammalia Dynll2 16 34 33
  • 97.75 (n)
dog
(Canis familiaris)
Mammalia DYNLL2 33 34
  • 97.38 (n)
cow
(Bos Taurus)
Mammalia DYNLL2 33 34
  • 96.63 (n)
chicken
(Gallus gallus)
Aves DYNLL2 34 33
  • 88.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLL2 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dynll2 33
  • 86.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8719 33
zebrafish
(Danio rerio)
Actinopterygii dynll2a 34
  • 99 (a)
OneToMany
dynll2b 33 34
  • 83.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001335 33
  • 77.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta ctp 33
  • 76.03 (n)
worm
(Caenorhabditis elegans)
Secernentea dlc-1 34 33
  • 82.4 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 34
  • 47 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os01g0256400 33
  • 70.73 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.14337 33
corn
(Zea mays)
Liliopsida Zm.10206 33
sea squirt
(Ciona savignyi)
Ascidiacea CS-DLC1 34
  • 96 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dlc2 33
  • 69.05 (n)
Species where no ortholog for DYNLL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DYNLL2 Gene

ENSEMBL:
Gene Tree for DYNLL2 (if available)
TreeFam:
Gene Tree for DYNLL2 (if available)

Paralogs for DYNLL2 Gene

Paralogs for DYNLL2 Gene

(4) SIMAP similar genes for DYNLL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DYNLL2: view

Variants for DYNLL2 Gene

Sequence variations from dbSNP and Humsavar for DYNLL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000743691 -- 58,090,587(+) TGAGG(A/G)TAGAA downstream-variant-500B
rs1001570314 -- 58,085,826(+) GGAAG(A/G)AAGGC intron-variant
rs1002012086 -- 58,089,494(+) GTTTA(-/T)TTTTC utr-variant-3-prime
rs1002110391 -- 58,084,033(+) GGAGA(A/G)GGCTC intron-variant, upstream-variant-2KB
rs1002344366 -- 58,090,556(+) ACTGT(A/G)GATGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DYNLL2 Gene

Variant ID Type Subtype PubMed ID
nsv1127584 CNV deletion 24896259
nsv833497 CNV loss 17160897

Variation tolerance for DYNLL2 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNLL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLL2 Gene

Disorders for DYNLL2 Gene

Relevant External Links for DYNLL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNLL2

No disorders were found for DYNLL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNLL2 Gene

Publications for DYNLL2 Gene

  1. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister KK … Vallee RB (The Journal of cell biology 2005) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. (PMID: 14561217) Day CL … Hinds MG (The Biochemical journal 2004) 3 22 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for DYNLL2 Gene

Sources for DYNLL2 Gene

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