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DYNLL1 Gene

protein-coding   GIFtS: 66
GCID: GC12P120908

Dynein, Light Chain, LC8-Type 1

(Previous names: dynein, cytoplasmic, light polypeptide 1)
(Previous symbol: DNCL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Light Chain, LC8-Type 11 2     DNCLC12 3
DNCL11 2 3 5     LC82
DLC12 3 5     LC8a2
PIN2 3 5     Cytoplasmic Dynein Light Polypeptide2
Dynein, Cytoplasmic, Light Polypeptide 11 2     Dynein Light Chain 1, Cytoplasmic2
Protein Inhibitor Of Neuronal Nitric Oxide Synthase2 3     hdlc12
8 KDa Dynein Light Chain2 3     HDLC13
DLC82 3     Dynein Light Chain LC8-Type 13

External Ids:    HGNC: 154761   Entrez Gene: 86552   Ensembl: ENSG000000889867   OMIM: 6015625   UniProtKB: P631673   

Export aliases for DYNLL1 gene to outside databases

Previous GC identifers: GC12P119397 GC12P117917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYNLL1 Gene:
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two
force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain,
which contains a varying number of accessory intermediate chains. The complex is involved in intracellular
transport and motility. The protein described in this record is a light chain and exists as part of this complex
but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this
protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may
regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate
transcriptional splice variants have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for DYNLL1 Gene:
DYNLL1 (dynein, light chain, LC8-type 1) is a protein-coding gene. Diseases associated with DYNLL1 include mature cataract, and cerebral cavernous malformations 3. GO annotations related to this gene include protein C-terminus binding and protein homodimerization activity. An important paralog of this gene is DNAL4.

UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures
Function: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase
Function: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1
Function: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the
BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2
thus neutralizing its antiapoptotic activity

Gene Wiki entry for DYNLL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNLL1 gene promoter:
         Max   GR   GR-beta   GR-alpha   Egr-4   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DYNLL1 promoter sequence
   Search Chromatin IP Primers for DYNLL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNLL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.23

DYNLL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNLL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120908:  view genomic region     (about GC identifiers)

Start:
120,907,653 bp from pter      End:
120,936,298 bp from pter
Size:
28,646 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167 (See protein sequence)
Recommended Name: Dynein light chain 1, cytoplasmic  
Size: 89 amino acids; 10366 Da
Subunit: Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein
1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by
intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary
in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable
homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and
the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17.
Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation
functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts
with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis.
Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein;
this interaction is critical for intracellular microtubule-dependent viral genome transport toward the
centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5,
PLK1, DYNLL1 and SGOL2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence
may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.
Interacts with NEK9 (not phosphorylated at 'Ser-944')
3 PDB 3D structures from and Proteopedia for DYNLL1:
1CMI (3D)        3ZKE (3D)        3ZKF (3D)    
Secondary accessions: Q15701

Explore the universe of human proteins at neXtProt for DYNLL1: NX_P63167

Explore proteomics data for DYNLL1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is
    phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for
    PAK1 and the phosphorylation could not be demonstrated in vitro1
  • Ubiquitination2 at Lys9, Lys31, Lys36, Lys49
  • Modification sites at PhosphoSitePlus

  • See DYNLL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001032583.1  NP_001032584.1  NP_003737.1  

    ENSEMBL proteins: 
     ENSP00000376297   ENSP00000448834   ENSP00000447907   ENSP00000242577   ENSP00000448608  
     ENSP00000376296   ENSP00000446596   ENSP00000447494   ENSP00000446614   ENSP00000449088  
    Reactome Protein details: P63167

    DYNLL1 Human Recombinant Protein Products:

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    DYNLL1 Antibody Products:

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    Cloud-Clone Corp. CLIAs for DYNLL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    2 InterPro protein domains:
     IPR019763 Dynein_light_1/2_CS
     IPR001372 Dynein_light_chain_typ-1/2

    Graphical View of Domain Structure for InterPro Entry P63167

    ProtoNet protein and cluster: P63167

    UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167
    Similarity: Belongs to the dynein light chain family


    DYNLL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DYL1_HUMAN, P63167
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures
    Function: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase
    Function: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1
    Function: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the
    BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2
    thus neutralizing its antiapoptotic activity
    Induction: Up-regulated by ATMIN, PAK1 and estrogen

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI14607844
    GO:0008022protein C-terminus binding IEA--
    GO:0019899enzyme binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    DYNLL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DYNLL1:
     Cell division defect  Increased G2M DNA content 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dynll1):
     cellular  mortality/aging  no phenotypic analysis 

    DYNLL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dynll1tm1(KOMP)Wtsi for DYNLL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYNLL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DYNLL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DYNLL1

    miRNA
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    miRTarBase miRNAs that target DYNLL1:
    hsa-mir-92a-3p (MIRT049381)

    Block miRNA regulation of human, mouse, rat DYNLL1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DYNLL1:
    hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidDYNLL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DYNLL1
    Predesigned siRNA for gene silencing in human, mouse, rat DYNLL1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): DYNLL1 (NM_001037494)
    Sino Biological Human cDNA Clone for DYNLL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DYL1_HUMAN, P63167: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis
    translocates together with BCL2L11 to mitochondria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    nucleus5
    cytosol4
    plasma membrane4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA--
    GO:0005634nucleus IDA15891768
    GO:0005737cytoplasm IDA15891768
    GO:0005739mitochondrion IEA--
    GO:0005813centrosome IDA--

    DYNLL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYNLL1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BIM and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DYNLL1
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF


    Selected Reactome Pathways for DYNLL1 (see all 6)
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Activation of BIM and translocation to mitochondria
    MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for DYNLL1):
        Vasopressin-regulated water reabsorption


    DYNLL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DYNLL1: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DYNLL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNLL1 (P631671, 2, 3 ENSP000002425774) via UniProtKB, MINT, STRING, and/or I2D (see all 224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYZAPP0CAP11, 2, 3EBI-349105,EBI-7929343 MINT-7713307 MINT-7713382 MINT-7713439 MINT-7713280 MINT-7713396 MINT-7713416 I2D: score=1 
    B3GALT4O960242, 3MINT-8249201 I2D: score=2 
    ENSG00000226936O960242, 3MINT-8249201 I2D: score=2 
    ENSG00000235155O960242, 3MINT-8249201 I2D: score=2 
    RGS2P412202, 3MINT-63730 MINT-8268757 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006810transport IEA--

    DYNLL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYNLL1 (DYL1)

    1 HMDB Compound for DYNLL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Nitric oxideMononitrogen monoxide (see all 9)10102-43-9--

    2 Novoseek inferred chemical compound relationships for DYNLL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 50 40 8842789 (4), 17169380 (2), 8902202 (1), 9011564 (1) (see all 18)
    arginine 28.6 1 8653881 (1)



    DYNLL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DYNLL1 gene (3 alternative transcripts): 
    NM_001037494.1  NM_001037495.1  NM_003746.2  

    Unigene Cluster for DYNLL1:

    Dynein, light chain, LC8-type 1
    Hs.5120  [show with all ESTs]
    Unigene Representative Sequence: AK309022
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392509(uc001tyj.3) ENST00000549649 ENST00000548342 ENST00000242577(uc001tyl.3 uc001tym.3)
    ENST00000548214 ENST00000392508 ENST00000550178 ENST00000550845 ENST00000549989
    ENST00000552870 ENST00000552316
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    SwitchGear 3'UTR luciferase reporter plasmidDYNLL1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DYNLL1

    Additional mRNA sequence: 

    AK309022.1 AK311790.1 BC100289.1 BC104244.1 BC104245.1 CR407672.1 CR542128.1 U32944.1 

    Selected DOTS entries (see all 26):

    DT.92037299  DT.97864495  DT.87017756  DT.95079267  DT.95079262  DT.95079313  DT.92050506  DT.121184610 
    DT.91768590  DT.121184622  DT.121184649  DT.95079311  DT.100887692  DT.91768594  DT.91901906  DT.100887684 
    DT.91837056  DT.121184613  DT.121184614  DT.100001119  DT.100887683  DT.100887691  DT.87079971  DT.91768584 

    Selected AceView cDNA sequences (see all 951):

    BM787097 CA775480 BM834090 AI708159 H65698 CR542128 CN478546 BM827331 
    BI835694 CA308028 BQ269374 BM668764 CA447826 CB156690 BU580971 BE907838 
    AI279171 BM693484 CA867039 BM835845 BX328776 BM704166 AA127527 BQ016183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYNLL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGTGCCA
    DYNLL1 Expression
    About this image


    DYNLL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
    DYNLL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNLL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5120

    UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DYNLL1: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DYNLL1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dynll11 , 5 dynein light chain LC8-type 11, 5 92.88(n)1
    100(a)1
      5 (56.04 cM)5
    564551  NM_019682.41  NP_062656.31 
     1152971105 
    chicken
    (Gallus gallus)
    Aves DYNLL16
    dynein, light chain, LC8-type 1
    72(a)
    1 ↔ 1
    15(9288062-9289734)
    lizard
    (Anolis carolinensis)
    Reptilia DYNLL16
    dynein, light chain, LC8-type 1
    99(a)
    1 ↔ 1
    GL343338.1(90264-91354)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84212 Xenopus laevis transcribed sequence with strong similarity more 83.45(n)    48053605 
    zebrafish
    (Danio rerio)
    Actinopterygii dynll16
    dynein, light chain, LC8-type 1
    97(a)
    1 ↔ 1
    8(2662318-2666539) ENSDARG00000058454
    fruit fly
    (Drosophila melanogaster)
    Insecta ctp6
    Cdlc26
    Cytoplasmic dynein light chain 2
    94(a)
    94(a)
    many → 1
    many → 1
    X(4581825-4596067)
    2L(1344480-1345144)
    worm
    (Caenorhabditis elegans)
    Secernentea dlc-26
    dlc-36
    (see all 3)
    Protein DLC-2 (dlc-2) mRNA, complete cds
    Protein DLC-3, isoform a (dlc-3) mRNA, complete cd...
    (see all 3)
    38(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(12110587-12111577) WBGene00010888
    IV(16432231-16437957) WBGene00012424
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DYN2(YDR424C)4 Cytoplasmic light chain dynein, microtubule motor protein; more   --   4(1319841-1319387) 852034  NP_010712.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.8912 Vitis vinifera transcribed sequence with moderate similarity more 77.97(n)    CF512772.1 


    ENSEMBL Gene Tree for DYNLL1 (if available)
    TreeFam Gene Tree for DYNLL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYNLL1 gene
    DNAL42  DYNLL22  
    4 SIMAP similar genes for DYNLL1 using alignment to 4 protein entries:     DYL1_HUMAN (see all proteins):
    DNCL1    DYNLL2    LOC392067    DNAL4

    DYNLL1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for DYNLL1 (see all 7)
    PGOHUM00000239583 PGOHUM00000261846 PGOHUM00000248243 PGOHUM00000244625 PGOHUM00000238237


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYNLL1 (see all 352)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474879411,2
    C--120909616(+) TCACCC/GTGTTA 1 -- int10--------
    rs37593961,2
    C,F,A--120909693(-) CTCACG/ACCTGT 1 -- int13Minor allele frequency- A:0.33NA 6
    rs2013630111,2
    C--120909802(+) GCAAT-/AAAAAA 1 -- int10--------
    rs589504741,2
    C--120909980(+) GTAAC-/AAAAAA 1 -- int10--------
    rs47679021,2
    C,F,A,H--120910004(+) GCTTTC/TCAAAT 1 -- int121Minor allele frequency- T:0.27NS EA NA WA CSA 2348
    rs1923546381,2
    --120910093(+) AATTAC/GCATGC 1 -- int10--------
    rs1439009571,2
    C--120910224(+) GCCCTA/GGCCAA 1 -- int10--------
    rs1506267851,2
    --120910403(+) AAAAAA/GGTGCT 1 -- int10--------
    rs780344571,2
    C,F--120910425(+) TTGGGC/AAGTCT 1 -- int12Minor allele frequency- A:0.18CSA WA 120
    rs732213781,2
    C,F--120910521(+) TAATTG/ATGCAA 1 -- int11Minor allele frequency- A:0.07NA 120

    HapMap Linkage Disequilibrium report for DYNLL1 (120907653 - 120936298 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DYNLL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509482CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYNLL1
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNLL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601562    OMIM disorders: --

    20 diseases for DYNLL1:    
    About MalaCards
    mature cataract    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation
    neuronitis    keloids    lissencephaly    rabies
    sickle cell disease    cataract    cerebritis    herpes simplex
    peritonitis    cystic fibrosis    multiple myeloma    myeloma
    hypertension    endotheliitis    hiv-1    breast cancer


    DYNLL1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DYNLL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 18650427 (1), 15193260 (1)

    Genetic Association Database (GAD): DYNLL1
    Human Genome Epidemiology (HuGE) Navigator: DYNLL1 (1 document)

    Export disorders for DYNLL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYNLL1 gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with DYNLL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PubMed id 8628263)1, 2, 3 Dick T.... Chia W. (Mol. Cell. Biol. 1996)
    2. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PubMed id 18084006)1, 2, 9 Song C.... Kumar R. (J. Biol. Chem. 2008)
    3. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PubMed id 15193260)1, 2, 9 Vadlamudi R.K.... Kumar R. (Cancer Cell 2004)
    4. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (PubMed id 10198631)1, 2, 9 Puthalakath H.... Strasser A. (Mol. Cell 1999)
    5. Structure of the PIN/LC8 dimer with a bound peptide. (PubMed id 10426949)1, 2, 9 Liang J.... Clardy J. (Nat. Struct. Biol. 1999)
    6. Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation. (PubMed id 23482567)1, 2 Gallego P.... Reverter D. (J. Biol. Chem. 2013)
    7. ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. (PubMed id 22167198)1, 2 Jurado S.... Heierhorst J. (J. Biol. Chem. 2012)
    8. Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A. (PubMed id 20412299)1, 2 Garcia-Mayoral M.F.... Bruix M. (FEBS J. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. (PubMed id 16684779)1, 2 Rayala S.K.... Kumar R. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8655 HGNC: 15476 AceView: DNCL1 Ensembl:ENSG00000088986 euGenes: HUgn8655
    ECgene: DYNLL1 Kegg: 8655 H-InvDB: DYNLL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNLL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYNLL1 gene:
    Search GeneIP for patents involving DYNLL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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