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Aliases for DYNLL1 Gene

Aliases for DYNLL1 Gene

  • Dynein Light Chain LC8-Type 1 2 3 4
  • Protein Inhibitor Of Neuronal Nitric Oxide Synthase 3 4
  • Dynein, Cytoplasmic, Light Polypeptide 1 2 3
  • Dynein, Light Chain, LC8-Type 1 3 5
  • 8 KDa Dynein Light Chain 3 4
  • DNCLC1 3 4
  • Hdlc1 3 4
  • DNCL1 3 4
  • DLC1 3 4
  • DLC8 3 4
  • PIN 3 4
  • Cytoplasmic Dynein Light Polypeptide 3
  • LC8a 3
  • LC8 3

External Ids for DYNLL1 Gene

Previous HGNC Symbols for DYNLL1 Gene

  • DNCL1

Previous GeneCards Identifiers for DYNLL1 Gene

  • GC12P119397
  • GC12P120908
  • GC12P117917

Summaries for DYNLL1 Gene

Entrez Gene Summary for DYNLL1 Gene

  • Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYNLL1 Gene

DYNLL1 (Dynein Light Chain LC8-Type 1) is a Protein Coding gene. Diseases associated with DYNLL1 include Chronic Intestinal Vascular Insufficiency. Among its related pathways are Golgi-to-ER retrograde transport and Immune System. GO annotations related to this gene include protein homodimerization activity and protein domain specific binding. An important paralog of this gene is DNAL4.

UniProtKB/Swiss-Prot for DYNLL1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

  • Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.

  • Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

  • Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Gene Wiki entry for DYNLL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLL1 Gene

Genomics for DYNLL1 Gene

Regulatory Elements for DYNLL1 Gene

Enhancers for DYNLL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DYNLL1 on UCSC Golden Path with GeneCards custom track

Promoters for DYNLL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DYNLL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DYNLL1 Gene

Chromosome:
12
Start:
120,469,850 bp from pter
End:
120,498,495 bp from pter
Size:
28,646 bases
Orientation:
Plus strand

Genomic View for DYNLL1 Gene

Genes around DYNLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL1 Gene

Proteins for DYNLL1 Gene

  • Protein details for DYNLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63167-DYL1_HUMAN
    Recommended name:
    Dynein light chain 1, cytoplasmic
    Protein Accession:
    P63167
    Secondary Accessions:
    • Q15701

    Protein attributes for DYNLL1 Gene

    Size:
    89 amino acids
    Molecular mass:
    10366 Da
    Quaternary structure:
    • Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at Ser-944).

    Three dimensional structures from OCA and Proteopedia for DYNLL1 Gene

neXtProt entry for DYNLL1 Gene

Proteomics data for DYNLL1 Gene at MOPED

Post-translational modifications for DYNLL1 Gene

  • Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
  • Ubiquitination at Lys 9, Lys 31, and Lys 36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DYNLL1 Gene

Domains & Families for DYNLL1 Gene

Gene Families for DYNLL1 Gene

Protein Domains for DYNLL1 Gene

Graphical View of Domain Structure for InterPro Entry

P63167

UniProtKB/Swiss-Prot:

DYL1_HUMAN :
  • Belongs to the dynein light chain family.
Family:
  • Belongs to the dynein light chain family.
genes like me logo Genes that share domains with DYNLL1: view

Function for DYNLL1 Gene

Molecular function for DYNLL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
UniProtKB/Swiss-Prot Function:
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
UniProtKB/Swiss-Prot Function:
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
UniProtKB/Swiss-Prot Function:
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by ATMIN, PAK1 and estrogen.
genes like me logo Genes that share phenotypes with DYNLL1: view

Animal Models for DYNLL1 Gene

MGI Knock Outs for DYNLL1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYNLL1 Gene

Localization for DYNLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL1 Gene

Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLL1 Gene COMPARTMENTS Subcellular localization image for DYNLL1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20133940
GO:0005634 nucleus IDA 15891768
GO:0005868 cytoplasmic dynein complex ISS --
GO:0005929 cilium IEA --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with DYNLL1: view

Pathways & Interactions for DYNLL1 Gene

genes like me logo Genes that share pathways with DYNLL1: view

SIGNOR curated interactions for DYNLL1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA,TAS --
GO:0007017 microtubule-based process IEA --
GO:0007292 female gamete generation TAS 8628263
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DYNLL1: view

Drugs & Compounds for DYNLL1 Gene

(2) Drugs for DYNLL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 576
genes like me logo Genes that share compounds with DYNLL1: view

Transcripts for DYNLL1 Gene

Unigene Clusters for DYNLL1 Gene

Dynein, light chain, LC8-type 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL1 Gene

No ASD Table

Relevant External Links for DYNLL1 Gene

GeneLoc Exon Structure for
DYNLL1
ECgene alternative splicing isoforms for
DYNLL1

Expression for DYNLL1 Gene

mRNA expression in normal human tissues for DYNLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLL1 Gene



SOURCE GeneReport for Unigene cluster for DYNLL1 Gene Hs.5120

mRNA Expression by UniProt/SwissProt for DYNLL1 Gene

P63167-DYL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DYNLL1: view

Protein tissue co-expression partners for DYNLL1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for DYNLL1 Gene

Orthologs for DYNLL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DYNLL1 35
  • 93.26 (n)
  • 100 (a)
-- 36
  • 98 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
DYNLL1 36
  • 100 (a)
OneToMany
DYNLL1 36
  • 100 (a)
OneToMany
DYNLL1 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DYNLL1 35
  • 94.76 (n)
  • 100 (a)
DYNLL1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynll1 35
  • 92.88 (n)
  • 100 (a)
Dynll1 16
Dynll1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYNLL1 35
  • 100 (n)
  • 100 (a)
DYNLL1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynll1 35
  • 92.51 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia DYNLL1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNLL1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLL1 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8421 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10095 35
zebrafish
(Danio rerio)
Actinopterygii dynll1 36
  • 97 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdlc2 36
  • 94 (a)
OneToMany
ctp 36
  • 94 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dlc-2 36
  • 38 (a)
ManyToMany
dlc-3 36
  • 22 (a)
ManyToMany
dlc-4 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 36
  • 47 (a)
OneToMany
DYN2 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.891 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5239 35
Species with no ortholog for DYNLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYNLL1 Gene

ENSEMBL:
Gene Tree for DYNLL1 (if available)
TreeFam:
Gene Tree for DYNLL1 (if available)

Paralogs for DYNLL1 Gene

Paralogs for DYNLL1 Gene

(4) SIMAP similar genes for DYNLL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DYNLL1: view

Variants for DYNLL1 Gene

Sequence variations from dbSNP and Humsavar for DYNLL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10849753 -- 120,473,010(+) ATATT(C/T)AACAT intron-variant
rs540520 -- 120,473,983(-) GTGTC(C/T)ttttt intron-variant
rs548087 -- 120,488,395(-) tagcc(G/T)gagag intron-variant
rs550876 -- 120,488,678(+) aggcc(A/G)aggcg intron-variant
rs565266 -- 120,482,284(+) cagcc(C/T)gggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLL1 Gene

Variant ID Type Subtype PubMed ID
nsv509482 CNV Insertion 20534489

Variation tolerance for DYNLL1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DYNLL1 Gene

Disorders for DYNLL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYNLL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DYNLL1

Genetic Association Database (GAD)
DYNLL1
Human Genome Epidemiology (HuGE) Navigator
DYNLL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNLL1
genes like me logo Genes that share disorders with DYNLL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLL1 Gene

Publications for DYNLL1 Gene

  1. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PMID: 8628263) Dick T. … Chia W. (Mol. Cell. Biol. 1996) 2 3 4 67
  2. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PMID: 18084006) Song C. … Kumar R. (J. Biol. Chem. 2008) 3 23
  3. Regulation and function of the protein inhibitor of nitric oxide synthase (PIN)/dynein light chain 8 (LC8) in a human mast cell line. (PMID: 17169380) McCauley S.D. … Befus A.D. (Life Sci. 2007) 3 23
  4. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  5. Dynein light chain 1 phosphorylation controls macropinocytosis. (PMID: 15504720) Yang Z. … Kumar R. (J. Biol. Chem. 2005) 3 23

Products for DYNLL1 Gene

Sources for DYNLL1 Gene

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