DYNLL1 Gene
protein-coding GIFtS: 64
GCID: GC12P120908
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dynein, light chain, LC8-type 1(Previous names: dynein, cytoplasmic, light polypeptide 1 )
(Previous symbol: DNCL1)
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Aliases
for DYNLL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dynein, Light Chain, LC8-Type 11 2 | | Protein Inhibitor Of Neuronal Nitric Oxide Synthase2 3 | | DLC11 2 3 5 | | 8 KDa Dynein Light Chain2 3 | | DNCL11 2 3 5 | | DNCLC12 3 | | PIN1 2 3 5 | | LC8a2 | | DLC81 2 3 | | Cytoplasmic Dynein Light Polypeptide2 | | LC81 2 | | Dynein Light Chain 1, Cytoplasmic2 | | Dynein, Cytoplasmic, Light Polypeptide 11 2 | | HDLC13 | | Hdlc11 | | Dynein Light Chain LC8-Type 13 |
Export aliases for DYNLL1 gene to outside databasesPrevious GC identifers: GC12P119397 GC12P117917 |
Summaries
for DYNLL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DYNLL1:
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain twoforce-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, whichcontains a varying number of accessory intermediate chains. The complex is involved in intracellular transport andmotility. The protein described in this record is a light chain and exists as part of this complex but also physicallyinteracts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes theneuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologicprocesses through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have beencharacterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Mayplay a role in changing or maintaining the spatial distribution of cytoskeletal structuresFunction: Binds and inhibits the catalytic activity of neuronal nitric oxide synthaseFunction: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1Function: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli theBCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thusneutralizing its antiapoptotic activity
Gene Wiki entry for DYNLL1
|
Genomic Views
for DYNLL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYNLL1 gene promoter:
Max GR GR-beta GR-alpha Egr-4 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYNLL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.23 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.23DYNLL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P120908: view genomic region
(about GC identifiers)
Start:
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120,907,653 bp from pter |
End:
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120,936,298 bp from pter |
Size:
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28,646 bases |
Orientation:
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plus strand |
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Proteins
for DYNLL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167 (See
protein sequence)Recommended Name: Dynein light chain 1, cytoplasmic Size: 89 amino acids; 10366 Da
Subunit: Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediatechains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to theIC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly ofthe respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the ICdimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. TheWWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the targetchromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced inthe nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimericDYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellularmicrotubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin(SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with ATMIN; thisinteraction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1inhibits transactivation of its own promoter by ATMIN
Subcellular location: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocatestogether with BCL2L11 to mitochondria
1 PDB 3D structure from  and Proteopedia  for DYNLL1:1CMI (3D)
Secondary accessions: Q15701Explore the universe of human proteins at neXtProt for DYNLL1: NX_P63167
Post-translational modifications:
Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it isphosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1and the phosphorylation could not be demonstrated in vitro1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P63167
DYNLL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001032583.1 NP_001032584.1 NP_003737.1
ENSEMBL proteins: ENSP00000376297 ENSP00000448834 ENSP00000447907 ENSP00000242577 ENSP00000448608 ENSP00000376296 ENSP00000446596 ENSP00000447494 ENSP00000446614 ENSP00000449088 Reactome Protein details: P63167
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
DYNLL1 for ontologies About GeneDecksing
DYNLL1 Antibody Products:
Assay Products for DYNLL1: |
Protein
Domains /
Families
for DYNLL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYNLL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P63167ProtoNet protein and cluster: P63167 UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167Similarity: Belongs to the dynein light chain family |
Function
for DYNLL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Mayplay a role in changing or maintaining the spatial distribution of cytoskeletal structuresFunction: Binds and inhibits the catalytic activity of neuronal nitric oxide synthaseFunction: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1Function: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli theBCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thusneutralizing its antiapoptotic activityInduction: Up-regulated by ATMIN, PAK1 and estrogen
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DYNLL1 (NM_001037494) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYNLL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
DYNLL1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DYNLL1:
Animal Models:
Mouse knock-out Dynll1tm1(KOMP)Wtsi for DYNLL1
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dynll1):
DYNLL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DYNLL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Immune System | | | 4 | MHC class II antigen presentation | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DYNLL1
2  GeneGo (Thomson Reuters) Pathways for DYNLL1
5/16 
Reactome Pathways for DYNLL1 (see all 16)
1 
Kegg Pathway (Kegg details for DYNLL1):
DYNLL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DYNLL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/186 Interacting proteins for DYNLL1 (P631671, 2, 3 ENSP000002425774) via UniProtKB, MINT, STRING, and/or I2D (see all 186)About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000086 | G2/M transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006810 | transport |
IEA | -- |
DYNLL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DYNLL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DYNLL1 for compounds About GeneDecksing
 Browse Tocris compounds for DYNLL1
1 HMDB Compound for DYNLL1 About this table
2 Novoseek chemical compound relationships for DYNLL1 gene About this table
Search CenterWatch for drugs/clinical trials and news about DYNLL1 / DYL1
|
Transcripts
for DYNLL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DYNLL1 gene (3 alternative transcripts): NM_001037494.1 NM_001037495.1 NM_003746.2 Unigene Cluster for DYNLL1: Dynein, light chain, LC8-type 1 Hs.5120 [show with all ESTs]Unigene Representative Sequence: AK30902211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392509(uc001tyj.3) ENST00000549649 ENST00000548342 ENST00000242577(uc001tyl.3 uc001tym.3)
ENST00000548214 ENST00000392508 ENST00000550178 ENST00000550845 ENST00000549989
ENST00000552870 ENST00000552316
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DYNLL1 (NM_001037494) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYNLL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL1 |
Additional cDNA sequence: AK309022.1 AK311790.1 BC100289.1 BC104244.1 BC104245.1 CR407672.1 CR542128.1 U32944.1 24/26 DOTS entries (see all 26): DT.92037299 DT.97864495 DT.87017756 DT.95079267 DT.95079262 DT.95079313 DT.92050506 DT.91768590 DT.121184610 DT.121184622 DT.121184649 DT.95079311 DT.100887692 DT.91768594 DT.91901906 DT.100887684 DT.91837056 DT.100001119 DT.121184613 DT.121184614 DT.100887683 DT.100887691 DT.87079971 DT.91768584 24/951 AceView cDNA sequences (see all 951): BM704166 BX328776 CA867039 BM835845 BM693484 AI279171 BE907838 BU580971 BM834090 CA312682 BM894223 BQ269374 BM315023 AA633050 CA867138 CN478546 CB156690 H65698 AI128720 CA942432 BM827331 BI835694 BM668764 BM664897
GeneLoc Exon Structure
|
Expression
for DYNLL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DYNLL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTGTGCCA
About this image
See DYNLL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYNLL1
SOURCE GeneReport for Unigene cluster: Hs.5120
UniProtKB/Swiss-Prot: DYL1_HUMAN, P63167Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including DYNLL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYNLL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYNLL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL1 |
Orthologs
for DYNLL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DYNLL1 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for DYNLL1 (if available)
TreeFam Gene Tree for DYNLL1 (if available) |
Paralogs
for DYNLL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DYNLL1 gene
- DNAL42 DYNLL22
4 SIMAP similar genes for DYNLL1 using alignment to 4 protein entries: DYL1_HUMAN (see all proteins):DNCL1 DYNLL2 LOC392067 DNAL4
DYNLL1 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for DYNLL1 (see all 7)
PGOHUM00000239583 PGOHUM00000261846 PGOHUM00000248243 PGOHUM00000244625 PGOHUM00000238237
|
Genomic Variants
for DYNLL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DYNLL1 (120907653 - 120936298 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DYNLL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNLL1 |
|
Disorders
/ Diseases
for DYNLL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYNLL1 for disorders About GeneDecksing
OMIM gene information: 601562
OMIM disorders: --
20  diseases for DYNLL1: About MalaCardsneuronitis cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3
mature cataract sickle cell disease herpes simplex cystic fibrosis
multiple myeloma keloids cerebritis rabies
cataract myeloma fibrosis colon carcinoma
peritonitis hypertension carcinoma malaria
1 disease from the University of Copenhagen DISEASES database for DYNLL1:Mature cataract 1 Novoseek disease relationship for DYNLL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
18650427 (1), 15193260 (1) |
Human Genome Epidemiology (HuGE) Navigator: DYNLL1 (1 document)
Export disorders for DYNLL1 gene to outside databases
|
Publications
for DYNLL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DYNLL1 gene, integrated from 9 sources (see all 137):
(articles sorted by number of sources associating them with DYNLL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PubMed id 8628263)1, 2, 3 Dick T.... Chia W. (1996)
- Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PubMed id 18084006)1, 2, 9 Song C....Kumar R. (2008)
- Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PubMed id 15193260)1, 2, 9 Vadlamudi R.K....Kumar R. (2004)
- The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (PubMed id 10198631)1, 2, 9 Puthalakath H....Strasser A. (1999)
- Structure of the PIN/LC8 dimer with a bound peptide. (PubMed id 10426949)1, 2, 9 Liang J.... Clardy J. (1999)
- ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. (PubMed id 22167198)1, 2 Jurado S....Heierhorst J. (2012)
- Structural basis for the interaction between dynein l ight chain 1 and the glutamate channel homolog GRINL1A. (PubMed id 20412299)1, 2 GarcA-a-Mayoral M.F....Bruix M. (2010)
- Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. (PubMed id 16684779)1, 2 Rayala S.K.... Kumar R. (2006)
- Functional regulation of oestrogen receptor pathway by the dynein light chain 1. (PubMed id 15891768)1, 2 Rayala S.K....Kumar R. (2005)
- Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
|
External Searches for DYNLL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYNLL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYNLL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYNLL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DYNLL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DYNLL1 gene:
Search GeneIP for patents involving DYNLL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYNLL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for DYNLL1 | | OriGene shRNA RFP for DYNLL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DYNLL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYNLL1 | | | OriGene Protein Over-expression Lysate for DYNLL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DYNLL1 | | OriGene 3'-UTR Clone for DYNLL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNLL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DYNLL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DYNLL1 | | OriGene Custom Protein Services for DYNLL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYNLL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNLL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNLL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYNLL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNLL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNLL1 |
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| | | | Search Tocris compounds for DYNLL1 |
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 | | | DYNLL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNLL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DYNLL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNLL1 |
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