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Aliases for DYNLL1 Gene

Aliases for DYNLL1 Gene

  • Dynein, Light Chain, LC8-Type 1 2 3
  • DNCL1 3 4 6
  • DLC1 3 4 6
  • PIN 3 4 6
  • Protein Inhibitor Of Neuronal Nitric Oxide Synthase 3 4
  • Dynein, Cytoplasmic, Light Polypeptide 1 2 3
  • 8 KDa Dynein Light Chain 3 4
  • DNCLC1 3 4
  • Hdlc1 3 4
  • DLC8 3 4
  • Cytoplasmic Dynein Light Polypeptide 3
  • Dynein Light Chain 1, Cytoplasmic 3
  • Dynein Light Chain LC8-Type 1 4
  • LC8a 3
  • LC8 3

External Ids for DYNLL1 Gene

Previous HGNC Symbols for DYNLL1 Gene

  • DNCL1

Previous GeneCards Identifiers for DYNLL1 Gene

  • GC12P119397
  • GC12P120908
  • GC12P117917

Summaries for DYNLL1 Gene

Entrez Gene Summary for DYNLL1 Gene

  • Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYNLL1 Gene

DYNLL1 (Dynein, Light Chain, LC8-Type 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein homodimerization activity and protein C-terminus binding. An important paralog of this gene is DNAL4.

UniProtKB/Swiss-Prot for DYNLL1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures

  • Binds and inhibits the catalytic activity of neuronal nitric oxide synthase

  • Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1

  • Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity

Gene Wiki entry for DYNLL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLL1 Gene

Genomics for DYNLL1 Gene

Regulatory Elements for DYNLL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DYNLL1 Gene

Start:
120,469,850 bp from pter
End:
120,498,495 bp from pter
Size:
28,646 bases
Orientation:
Plus strand

Genomic View for DYNLL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL1 Gene

Proteins for DYNLL1 Gene

  • Protein details for DYNLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63167-DYL1_HUMAN
    Recommended name:
    Dynein light chain 1, cytoplasmic
    Protein Accession:
    P63167
    Secondary Accessions:
    • Q15701

    Protein attributes for DYNLL1 Gene

    Size:
    89 amino acids
    Molecular mass:
    10366 Da
    Quaternary structure:
    • Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at Ser-944).

    Three dimensional structures from OCA and Proteopedia for DYNLL1 Gene

neXtProt entry for DYNLL1 Gene

Proteomics data for DYNLL1 Gene at MOPED

Post-translational modifications for DYNLL1 Gene

  • Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
  • Ubiquitination at Lys9, Lys31, Lys36, and Lys49
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DYNLL1 Gene

Domains for DYNLL1 Gene

Gene Families for DYNLL1 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNLL1 Gene

Suggested Antigen Peptide Sequences for DYNLL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63167

UniProtKB/Swiss-Prot:

DYL1_HUMAN :
  • P63167
Family:
  • Belongs to the dynein light chain family.
genes like me logo Genes that share domains with DYNLL1: view

Function for DYNLL1 Gene

Molecular function for DYNLL1 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures
UniProtKB/Swiss-Prot Function: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase
UniProtKB/Swiss-Prot Function: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1
UniProtKB/Swiss-Prot Function: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity
UniProtKB/Swiss-Prot Induction: Up-regulated by ATMIN, PAK1 and estrogen.

Gene Ontology (GO) - Molecular Function for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 14607844
GO:0008022 protein C-terminus binding --
GO:0019899 enzyme binding IEA --
GO:0019904 protein domain specific binding --
genes like me logo Genes that share ontologies with DYNLL1: view

Phenotypes for DYNLL1 Gene

MGI mutant phenotypes for DYNLL1:
inferred from 2 alleles
GenomeRNAi human phenotypes for DYNLL1:
genes like me logo Genes that share phenotypes with DYNLL1: view

Animal Models for DYNLL1 Gene

MGI Knock Outs for DYNLL1:

Animal Model Products

CRISPR Products

miRNA for DYNLL1 Gene

miRTarBase miRNAs that target DYNLL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYNLL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DYNLL1 Gene

Localization for DYNLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL1 Gene

Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNLL1 Gene COMPARTMENTS Subcellular localization image for DYNLL1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 4
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20133940
GO:0005634 nucleus IDA 15891768
GO:0005737 cytoplasm IDA 15891768
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DYNLL1: view

Pathways for DYNLL1 Gene

genes like me logo Genes that share pathways with DYNLL1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with DYNLL1: view

Compounds for DYNLL1 Gene

(1) HMDB Compounds for DYNLL1 Gene

Compound Synonyms Cas Number PubMed IDs
Nitric oxide
  • Mononitrogen monoxide
10102-43-9

(2) Novoseek inferred chemical compound relationships for DYNLL1 Gene

Compound -log(P) Hits PubMed IDs
nitric oxide 50 22
arginine 28.6 1
genes like me logo Genes that share compounds with DYNLL1: view

Transcripts for DYNLL1 Gene

Unigene Clusters for DYNLL1 Gene

Dynein, light chain, LC8-type 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYNLL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL1 Gene

No ASD Table

Relevant External Links for DYNLL1 Gene

GeneLoc Exon Structure for
DYNLL1
ECgene alternative splicing isoforms for
DYNLL1

Expression for DYNLL1 Gene

mRNA expression in normal human tissues for DYNLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNLL1 Gene

SOURCE GeneReport for Unigene cluster for DYNLL1 Gene Hs.5120

mRNA Expression by UniProt/SwissProt for DYNLL1 Gene

P63167-DYL1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with DYNLL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DYNLL1 Gene

Orthologs for DYNLL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLL1 35
  • 100 (n)
  • 100 (a)
DYNLL1 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
DYNLL1 35
  • 93.26 (n)
  • 100 (a)
DYNLL1 36
  • 100 (a)
OneToMany
DYNLL1 36
  • 100 (a)
OneToMany
DYNLL1 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DYNLL1 35
  • 94.76 (n)
  • 100 (a)
DYNLL1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dynll1 35
  • 92.88 (n)
  • 100 (a)
Dynll1 16
Dynll1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNLL1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dynll1 35
  • 92.51 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves DYNLL1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLL1 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8421 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10095 35
zebrafish
(Danio rerio)
Actinopterygii dynll1 36
  • 97 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdlc2 36
  • 94 (a)
OneToMany
ctp 36
  • 94 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dlc-2 36
  • 38 (a)
ManyToMany
dlc-3 36
  • 22 (a)
ManyToMany
dlc-4 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 36
  • 47 (a)
OneToMany
DYN2 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.891 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5239 35
Species with no ortholog for DYNLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYNLL1 Gene

ENSEMBL:
Gene Tree for DYNLL1 (if available)
TreeFam:
Gene Tree for DYNLL1 (if available)

Paralogs for DYNLL1 Gene

Paralogs for DYNLL1 Gene

Selected SIMAP similar genes for DYNLL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DYNLL1: view

Variants for DYNLL1 Gene

Sequence variations from dbSNP and Humsavar for DYNLL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs540520 -- 120,473,983(-) GTGTC(C/T)ttttt intron-variant
rs548087 -- 120,488,395(-) tagcc(G/T)gagag intron-variant
rs550876 -- 120,488,678(+) aggcc(A/G)aggcg intron-variant
rs565266 -- 120,482,284(+) cagcc(C/T)gggca intron-variant
rs606443 -- 120,472,827(-) CCTAA(G/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLL1 Gene

Variant ID Type Subtype PubMed ID
nsv509482 CNV Insertion 20534489

Relevant External Links for DYNLL1 Gene

HapMap Linkage Disequilibrium report
DYNLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLL1 Gene

Disorders for DYNLL1 Gene

(1) Novoseek inferred disease relationships for DYNLL1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for DYNLL1

Genetic Association Database (GAD)
DYNLL1
Human Genome Epidemiology (HuGE) Navigator
DYNLL1
genes like me logo Genes that share disorders with DYNLL1: view

No data available for UniProtKB/Swiss-Prot for DYNLL1 Gene

Publications for DYNLL1 Gene

  1. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (PMID: 10198631) Puthalakath H. … Strasser A. (Mol. Cell 1999) 3 4 23
  2. Structure of the PIN/LC8 dimer with a bound peptide. (PMID: 10426949) Liang J. … Clardy J. (Nat. Struct. Biol. 1999) 3 4 23
  3. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PMID: 15193260) Vadlamudi R.K. … Kumar R. (Cancer Cell 2004) 3 4 23
  4. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PMID: 18084006) Song C. … Kumar R. (J. Biol. Chem. 2008) 3 4 23
  5. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PMID: 8628263) Dick T. … Chia W. (Mol. Cell. Biol. 1996) 2 3 4

Products for DYNLL1 Gene

Sources for DYNLL1 Gene

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