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Aliases for DYNLL1 Gene

Aliases for DYNLL1 Gene

  • Dynein Light Chain LC8-Type 1 2 3 4 5
  • Protein Inhibitor Of Neuronal Nitric Oxide Synthase 3 4
  • Dynein, Cytoplasmic, Light Polypeptide 1 2 3
  • 8 KDa Dynein Light Chain 3 4
  • DNCLC1 3 4
  • Hdlc1 3 4
  • DNCL1 3 4
  • DLC1 3 4
  • DLC8 3 4
  • PIN 3 4
  • Cytoplasmic Dynein Light Polypeptide 3
  • Dynein Light Chain 1, Cytoplasmic 3
  • LC8a 3
  • LC8 3

External Ids for DYNLL1 Gene

Previous HGNC Symbols for DYNLL1 Gene

  • DNCL1

Previous GeneCards Identifiers for DYNLL1 Gene

  • GC12P119397
  • GC12P120908
  • GC12P117917

Summaries for DYNLL1 Gene

Entrez Gene Summary for DYNLL1 Gene

  • Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DYNLL1 Gene

DYNLL1 (Dynein Light Chain LC8-Type 1) is a Protein Coding gene. Diseases associated with DYNLL1 include Chronic Intestinal Vascular Insufficiency. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Activation of BH3-only proteins. GO annotations related to this gene include protein homodimerization activity and protein domain specific binding. An important paralog of this gene is DYNLL2.

UniProtKB/Swiss-Prot for DYNLL1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

  • Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.

  • Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

  • Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Gene Wiki entry for DYNLL1 Gene

Additional gene information for DYNLL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNLL1 Gene

Genomics for DYNLL1 Gene

Regulatory Elements for DYNLL1 Gene

Enhancers for DYNLL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H120549 1.2 Ensembl ENCODE 11.2 +80.7 80662 1 PKNOX1 FOXA2 ATF1 ARID4B YY1 SLC30A9 ATF7 SP5 REST PPARG COQ5 GATC COX6A1 RPL29P24 NRAV DYNLL1 SRSF9 RPL31P52 TRIAP1 ENSG00000111780
GH12H120430 1.2 Ensembl ENCODE 11.1 -39.3 -39287 0 ATF1 ARID4B SIN3A ZNF2 CBX5 ZNF207 ZNF143 KLF7 ATF7 RUNX3 RPS27P25 MSI1 RPL31P52 PLA2G1B DYNLL1 SRSF9 RNU6-1088P SIRT4 PXN COX6A1
GH12H120494 1.1 ENCODE 11.7 +26.8 26751 3 HDGF ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 ZHX2 COQ5 GATC RPL29P24 RNF10 SRSF9 DYNLL1 RPL31P52 TRIAP1 ENSG00000111780 COX6A1
GH12H120583 1.2 Ensembl ENCODE 10.6 +114.4 114354 2 ARID4B GLIS2 ZNF143 ATF7 REST GLIS1 MXD3 KDM1A WT1 SP7 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ENSG00000256569 ACADS OASL DYNLL1
GH12H120580 1.1 ENCODE 10.6 +111.5 111544 1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569 OASL DYNLL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DYNLL1 on UCSC Golden Path with GeneCards custom track

Promoters for DYNLL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058315 -550 2201 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 REST

Genomic Location for DYNLL1 Gene

Chromosome:
12
Start:
120,469,850 bp from pter
End:
120,498,495 bp from pter
Size:
28,646 bases
Orientation:
Plus strand

Genomic View for DYNLL1 Gene

Genes around DYNLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNLL1 Gene

Proteins for DYNLL1 Gene

  • Protein details for DYNLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63167-DYL1_HUMAN
    Recommended name:
    Dynein light chain 1, cytoplasmic
    Protein Accession:
    P63167
    Secondary Accessions:
    • Q15701

    Protein attributes for DYNLL1 Gene

    Size:
    89 amino acids
    Molecular mass:
    10366 Da
    Quaternary structure:
    • Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with rabies P protein (By similarity). Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at Ser-944). Interacts with BICD2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DYNLL1 Gene

neXtProt entry for DYNLL1 Gene

Post-translational modifications for DYNLL1 Gene

  • Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.
  • Ubiquitination at isoforms=9, isoforms=31, and posLast=3636
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DYNLL1 Gene

Domains & Families for DYNLL1 Gene

Gene Families for DYNLL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DYNLL1 Gene

Graphical View of Domain Structure for InterPro Entry

P63167

UniProtKB/Swiss-Prot:

DYL1_HUMAN :
  • Belongs to the dynein light chain family.
Family:
  • Belongs to the dynein light chain family.
genes like me logo Genes that share domains with DYNLL1: view

Function for DYNLL1 Gene

Molecular function for DYNLL1 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
UniProtKB/Swiss-Prot Function:
Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.
UniProtKB/Swiss-Prot Function:
Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.
UniProtKB/Swiss-Prot Function:
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by ATMIN, PAK1 and estrogen.

Phenotypes From GWAS Catalog for DYNLL1 Gene

Gene Ontology (GO) - Molecular Function for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 14607844
GO:0008022 protein C-terminus binding IEA --
GO:0008092 cytoskeletal protein binding IBA --
GO:0008574 contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA --
genes like me logo Genes that share ontologies with DYNLL1: view
genes like me logo Genes that share phenotypes with DYNLL1: view

Animal Models for DYNLL1 Gene

MGI Knock Outs for DYNLL1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DYNLL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DYNLL1 Gene

Localization for DYNLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNLL1 Gene

Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNLL1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20133940
GO:0005634 nucleus IDA,IEA 15891768
GO:0005737 cytoplasm IDA,IEA 8628263
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DYNLL1: view

Pathways & Interactions for DYNLL1 Gene

genes like me logo Genes that share pathways with DYNLL1: view

SIGNOR curated interactions for DYNLL1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DYNLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
genes like me logo Genes that share ontologies with DYNLL1: view

Drugs & Compounds for DYNLL1 Gene

(2) Drugs for DYNLL1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 631
genes like me logo Genes that share compounds with DYNLL1: view

Transcripts for DYNLL1 Gene

Unigene Clusters for DYNLL1 Gene

Dynein, light chain, LC8-type 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DYNLL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DYNLL1 Gene

No ASD Table

Relevant External Links for DYNLL1 Gene

GeneLoc Exon Structure for
DYNLL1
ECgene alternative splicing isoforms for
DYNLL1

Expression for DYNLL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYNLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYNLL1 Gene



Protein tissue co-expression partners for DYNLL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYNLL1 Gene:

DYNLL1

SOURCE GeneReport for Unigene cluster for DYNLL1 Gene:

Hs.5120

mRNA Expression by UniProt/SwissProt for DYNLL1 Gene:

P63167-DYL1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DYNLL1 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Pancreas(4.3)
  • Kidney(3.7)
  • Lung(3.7)
  • Heart(3.4)
  • Skin(3.4)
  • Intestine(3.3)
  • Blood(2.4)
  • Gall bladder(2.2)
  • Spleen(2.2)
  • Stomach(2.2)
  • Adrenal gland(2.1)
  • Eye(2.1)
  • Lymph node(2.1)
  • Muscle(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with DYNLL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNLL1 Gene

Orthologs for DYNLL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DYNLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNLL1 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia DYNLL1 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNLL1 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 99 (a)
OneToMany
-- 34
  • 98 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
DYNLL1 33 34 34 34
  • 93.26 (n)
dog
(Canis familiaris)
Mammalia DYNLL1 33 34
  • 94.76 (n)
mouse
(Mus musculus)
Mammalia Dynll1 33 16 34
  • 92.88 (n)
rat
(Rattus norvegicus)
Mammalia Dynll1 33
  • 92.51 (n)
chicken
(Gallus gallus)
Aves DYNLL1 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNLL1 34
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8421 33
zebrafish
(Danio rerio)
Actinopterygii dynll1 34
  • 97 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10095 33
fruit fly
(Drosophila melanogaster)
Insecta ctp 34
  • 94 (a)
OneToMany
Cdlc2 34
  • 94 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dlc-2 34
  • 38 (a)
ManyToMany
dlc-3 34
  • 22 (a)
ManyToMany
dlc-4 34
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DYN2 34 36
  • 47 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.891 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5239 33
Species where no ortholog for DYNLL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DYNLL1 Gene

ENSEMBL:
Gene Tree for DYNLL1 (if available)
TreeFam:
Gene Tree for DYNLL1 (if available)

Paralogs for DYNLL1 Gene

Paralogs for DYNLL1 Gene

(4) SIMAP similar genes for DYNLL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DYNLL1: view

Variants for DYNLL1 Gene

Sequence variations from dbSNP and Humsavar for DYNLL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000168021 -- 120,473,566(+) GGCGC(A/C)CACCT intron-variant
rs1000172043 -- 120,471,504(+) CACCC(A/G)CATAT intron-variant, upstream-variant-2KB
rs1000204532 -- 120,471,138(+) GTGGG(C/T)GGATC intron-variant, upstream-variant-2KB
rs1000217439 -- 120,482,131(+) ATTTA(A/C)AGAGA intron-variant
rs1000386945 -- 120,477,953(+) TGGCT(A/C)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNLL1 Gene

Variant ID Type Subtype PubMed ID
esv3630925 CNV loss 21293372
nsv509482 CNV insertion 20534489
nsv973129 CNV duplication 23825009

Variation tolerance for DYNLL1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNLL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNLL1 Gene

Disorders for DYNLL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYNLL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic intestinal vascular insufficiency
  • chronic mesenteric ischemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DYNLL1

Genetic Association Database (GAD)
DYNLL1
Human Genome Epidemiology (HuGE) Navigator
DYNLL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNLL1
genes like me logo Genes that share disorders with DYNLL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNLL1 Gene

Publications for DYNLL1 Gene

  1. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PMID: 18084006) Song C … Kumar R (The Journal of biological chemistry 2008) 3 4 22 60
  2. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PMID: 15193260) Vadlamudi RK … Kumar R (Cancer cell 2004) 3 4 22 60
  3. Structure of the PIN/LC8 dimer with a bound peptide. (PMID: 10426949) Liang J … Clardy J (Nature structural biology 1999) 3 4 22 60
  4. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (PMID: 10198631) Puthalakath H … Strasser A (Molecular cell 1999) 3 4 22 60
  5. Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. (PMID: 8628263) Dick T … Chia W (Molecular and cellular biology 1996) 2 3 4 60

Products for DYNLL1 Gene

Sources for DYNLL1 Gene

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