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DYNC2LI1 Gene

protein-coding   GIFtS: 54
GCID: GC02P044001

Dynein, Cytoplasmic 2, Light Intermediate Chain 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Cytoplasmic 2, Light Intermediate Chain 11 2
Dynein 2 Light Intermediate Chain2 3
D2LIC2 3
LIC32 3
Cytoplasmic Dynein 2 Light Intermediate Chain 12

External Ids:    HGNC: 245951   Entrez Gene: 516262   Ensembl: ENSG000001380367   UniProtKB: Q8TCX13   

Export aliases for DYNC2LI1 gene to outside databases

Previous GC identifers: GC02P043913 GC02P043737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DYNC2LI1 Gene:
DYNC2LI1 (dynein, cytoplasmic 2, light intermediate chain 1) is a protein-coding gene. GO annotations related to this gene include motor activity.

UniProtKB/Swiss-Prot: DC2L1_HUMAN, Q8TCX1
Function: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNC2LI1 gene promoter:
         COUP-TF1   AML1a   COUP   FOXO3   HNF-4alpha2   HNF-4alpha1   FOXO3b   COUP-TF   HNF-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNC2LI1 promoter sequence
   Search Chromatin IP Primers for DYNC2LI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNC2LI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1-p24.1   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p25.1-p24.1

DYNC2LI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNC2LI1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P044001:  view genomic region     (about GC identifiers)

Start:
44,001,178 bp from pter      End:
44,037,149 bp from pter
Size:
35,972 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DC2L1_HUMAN, Q8TCX1 (See protein sequence)
Recommended Name: Cytoplasmic dynein 2 light intermediate chain 1  
Size: 351 amino acids; 39625 Da
Subunit: The cytoplasmic dynein complex 2 is probably composed by a DYNC2H1 homodimer and a number of DYNC2LI1
light intermediate chains (By similarity)
Sequence caution: Sequence=AAD34055.1; Type=Frameshift; Positions=163, 167;
Secondary accessions: A8MVJ5 Q53F57 Q6PDB2 Q8IWA3 Q96B03 Q96J00 Q9Y370 Q9Y3S9
Alternative splicing: 5 isoforms:  Q8TCX1-1   Q8TCX1-2   Q8TCX1-3   Q8TCX1-4   Q8TCX1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DYNC2LI1: NX_Q8TCX1

Explore proteomics data for DYNC2LI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys329
  • Modification sites at PhosphoSitePlus

  • See DYNC2LI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180393.1  NP_056337.1  NP_057092.2  

    ENSEMBL proteins: 
     ENSP00000260605   ENSP00000430356   ENSP00000385738   ENSP00000430525   ENSP00000381804  
     ENSP00000474032   ENSP00000428082   ENSP00000367850   ENSP00000388941  
    Reactome Protein details: Q8TCX1

    DYNC2LI1 Human Recombinant Protein Products:

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    Novus Biologicals DYNC2LI1 Protein
    Novus Biologicals DYNC2LI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DYNC2LI1

     
    Search eBioscience for Proteins for DYNC2LI1 

     
    antibodies-online proteins for DYNC2LI1 (4 products) 

     
    Search antibodies-online for peptides for DYNC2LI1

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    antibodies-online antibodies for DYNC2LI1 (6 products) 

    DYNC2LI1 Assay Products:

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    Cloud-Clone Corp. ELISAs for DYNC2LI1
    Cloud-Clone Corp. CLIAs for DYNC2LI1
    Search eBioscience for ELISAs for DYNC2LI1 
    Search antibodies-online for kits for DYNC2LI1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR022780 Dynein_light_int_chain

    Graphical View of Domain Structure for InterPro Entry Q8TCX1

    ProtoNet protein and cluster: Q8TCX1

    UniProtKB/Swiss-Prot: DC2L1_HUMAN, Q8TCX1
    Similarity: Belongs to the dynein light intermediate chain family


    Find genes that share domains with DYNC2LI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DC2L1_HUMAN, Q8TCX1
    Function: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with DYNC2LI1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DYNC2LI1:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dync2li1):
     cardiovascular system  craniofacial  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  nervous system 

    Find genes that share phenotypes with DYNC2LI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dync2li1tm1Aar for DYNC2LI1

       genOway: Develop your customized and physiologically relevant rodent model for DYNC2LI1

    miRNA
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    miRTarBase miRNAs that target DYNC2LI1:
    hsa-mir-26b-5p (MIRT029378)

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    Selected qRT-PCR Assays for microRNAs that regulate DYNC2LI1 (see all 28):
    hsa-miR-579 hsa-miR-19b-2* hsa-miR-16-2* hsa-let-7a-2* hsa-miR-138-2* hsa-miR-340 hsa-miR-105 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidDYNC2LI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DYNC2LI1
    Predesigned siRNA for gene silencing in human, mouse, rat DYNC2LI1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DC2L1_HUMAN, Q8TCX1: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm (By similarity).
    Note=Localizes to the apical cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton3
    nucleus2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005858axonemal dynein complex ISS12802074
    GO:0005881colocalizes with cytoplasmic microtubule ISS--
    GO:0005930axoneme ISS--
    GO:0030990colocalizes with intraciliary transport particle ISS--

    Find genes that share ontologies with DYNC2LI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYNC2LI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    3Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    4MHC class II antigen presentation
    MHC class II antigen presentation


    Find genes that share SuperPaths with DYNC2LI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DYNC2LI1
        MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for DYNC2LI1):
        Vasopressin-regulated water reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Array including DYNC2LI1: 
              Primary Cilia in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DYNC2LI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNC2LI1 (Q8TCX11, 2, 3 ENSP000002606054) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOD1P004411, 2, 3, ENSP000002701424EBI-8568003,EBI-990792 MINT-8141655 MINT-8141681 MINT-8141720 MINT-8141617 I2D: score=1 STRING: ENSP00000270142
    DCTN1Q142032, 3, ENSP000003547914MINT-8141655 MINT-8141681 MINT-8141769 I2D: score=1 STRING: ENSP00000354791
    BAG3O958172, ENSP000003580814MINT-8141655 MINT-8141681 MINT-8141617 MINT-8141574 STRING: ENSP00000358081
    DYNC2H1Q8NCM83, ENSP000003811674I2D: score=2 STRING: ENSP00000381167
    DYNC1H1Q142043, ENSP000003489654I2D: score=1 STRING: ENSP00000348965
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007368determination of left/right symmetry IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--
    GO:0042384cilium assembly IEA--

    Find genes that share ontologies with DYNC2LI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYNC2LI1 (DC2L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DYNC2LI1 gene (4 alternative transcripts): 
    NM_001012665.1  NM_001193464.1  NM_015522.3  NM_016008.3  

    Unigene Cluster for DYNC2LI1:

    Dynein, cytoplasmic 2, light intermediate chain 1
    Hs.371597  [show with all ESTs]
    Unigene Representative Sequence: BC040558
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260605(uc002rtl.3 uc002rtk.3 uc010ynz.2) ENST00000496980
    ENST00000406852(uc002rth.3) ENST00000479242 ENST00000398823(uc002rti.3)
    ENST00000489222 ENST00000605786 ENST00000462426 ENST00000378587(uc021vgq.1)
    ENST00000482738 ENST00000443170
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DYNC2LI1 (see all 28):
    hsa-miR-579 hsa-miR-19b-2* hsa-miR-16-2* hsa-let-7a-2* hsa-miR-138-2* hsa-miR-340 hsa-miR-105 hsa-miR-548a-3p
    SwitchGear 3'UTR luciferase reporter plasmidDYNC2LI1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DYNC2LI1
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    GenScript: all cDNA clones in your preferred vector (see all 3): DYNC2LI1 (NM_001193464)
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      QuantiTect SYBR Green Assays in human, mouse, rat DYNC2LI1
      QuantiFast Probe-based Assays in human, mouse, rat DYNC2LI1

    Additional mRNA sequence: 

    AF151818.1 AK074206.1 AK223432.1 AK301489.1 AL050006.1 AY083346.1 BC006969.1 BC016324.1 
    BC035126.1 BC040558.1 BC058823.1 

    15 DOTS entries:

    DT.214136  DT.91749508  DT.75100391  DT.429829  DT.100781420  DT.95093714  DT.91749506  DT.91749510 
    DT.91749504  DT.100716541  DT.40131772  DT.86855215  DT.91845495  DT.120987498  DT.75129730 

    Selected AceView cDNA sequences (see all 208):

    CR622142 BX110894 BU521477 AI678208 AA429805 BX112726 CR600166 BC016324 
    AA633343 AI920989 BQ432334 AI985163 AI342230 NM_016008 AI802282 BQ787216 
    AI253766 AA436488 AA826115 BE349047 AA450294 AI809986 AW169765 BM764146 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYNC2LI1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:                          -                             -     -           -                             -                       -               
    SP2:                          -                             -     -           -                             -                       -               
    SP3:                                                        -     -           -                                                                     
    SP4:                                                                          -                             -                                       
    SP5:                                                                                                        -                                       


    ECgene alternative splicing isoforms for DYNC2LI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYNC2LI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACTCACC
    DYNC2LI1 Expression
    About this image

    DYNC2LI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNC2LI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371597
        Pathway & Disease-focused RT2 Profiler PCR Array including DYNC2LI1: 
              Primary Cilia in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DYNC2LI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNC2LI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DYNC2LI1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dync2li11 , 5 dynein cytoplasmic 2 light intermediate chain 11, 5 83.95(n)1
    87.75(a)1
      17 (55.02 cM)5
    2135751  NM_172256.11  NP_758460.11 
     846264965 
    chicken
    (Gallus gallus)
    Aves DYNC2LI11 dynein, cytoplasmic 2, light intermediate chain 1 73.1(n)
    66.28(a)
      421400  XM_419456.4  XP_419456.3 
    lizard
    (Anolis carolinensis)
    Reptilia DYNC2LI16
    dynein, cytoplasmic 2, light intermediate chain 1
    70(a)
    1 ↔ 1
    GL343231.1(1756081-1793562)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004985701 cytoplasmic dynein 2 light intermediate chain 1-like 70.27(n)
    68.83(a)
      100498570  XM_002932392.2  XP_002932438.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636732 hypothetical protein MGC63673 75.45(n)   393452  BC055198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37691 CG3769 45.31(n)
    36.61(a)
      34262  NM_135445.3  NP_609289.1 
    worm
    (Caenorhabditis elegans)
    Secernentea xbx-11 xbx-1 50.53(n)
    37.18(a)
      184080  NM_074282.2  NP_506683.2 


    ENSEMBL Gene Tree for DYNC2LI1 (if available)
    TreeFam Gene Tree for DYNC2LI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYNC2LI1 gene
    Selected SIMAP similar genes for DYNC2LI1 using alignment to 6 protein entries:     DC2L1_HUMAN (see all proteins) (see all similar genes):
    LDLRAD3    RRM2B    SEPSECS    AGBL3    FLJ00047    NLRC5
    ARIH1    ARL6IP5    BIRC3    EIF3G    C12orf76    SEC14L3
    TNNT1    pp12301    NDC80    ADCK1    DPP9    FCER1G

    Find genes that share paralogs with DYNC2LI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYNC2LI1 (see all 1012)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7252381,2
    C,F,O,A,H--43999182(-) TGGTGG/AAGCTA 3 -- us2k1112Minor allele frequency- A:0.28NS EA NA PA EU CA WA CSA 8616
    rs413617441,2
    C,F--43999204(+) TGATCG/ACAACC 3 -- us2k17Minor allele frequency- A:0.05NS EA NA WA 548
    rs1853966171,2
    --43999251(+) CCTTTA/TCCCTT 3 -- us2k10--------
    rs104959081,2
    C,F,H--43999312(+) TCCTTC/TCATTC 3 -- us2k1 trp389Minor allele frequency- T:0.04NS EA PA EU CA WA NA 4740
    rs38347871,2
    C--43999332(-) TGAAG-/ATTGTTC 3 -- us2k10--------
    rs2005317951,2
    C--43999332(-) GAAGAG/TTGTTC 3 -- us2k10--------
    rs23745741,2
    C,F,A,H--43999558(+) GTACTC/AGTACT 3 -- us2k112Minor allele frequency- A:0.39NS EA NA WA CSA 785
    rs1905904001,2
    --43999678(+) CTAGAA/CCCCAA 3 -- us2k10--------
    rs1820653301,2
    --43999691(+) CATTAA/CAATTC 3 -- us2k10--------
    rs37625711,2
    C,F,A,H--43999734(-) GCCAGA/CCTTTA 3 -- us2k129Minor allele frequency- C:0.32EA NA NS WA CSA 4392

    HapMap Linkage Disequilibrium report for DYNC2LI1 (44001178 - 44037149 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DYNC2LI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873978CNV Loss21882294
    nsv873980CNV Loss21882294
    nsv873979CNV Loss21882294
    dgv59n68CNV Gain17160897
    nsv457174CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DYNC2LI1
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNC2LI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for DYNC2LI1:
    Situs inversus

    Find genes that share disorders with DYNC2LI1           About GenesLikeMe


    Export disorders for DYNC2LI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYNC2LI1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DYNC2LI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2. (PubMed id 11907264)1, 2, 3 Grissom P.M.... McIntosh J.R. (Mol. Biol. Cell 2002)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells. (PubMed id 12802074)1 Perrone C.A....Porter M.E. (Mol. Biol. Cell 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51626 HGNC: 24595 AceView: D2LIC Ensembl:ENSG00000138036 euGenes: HUgn51626
    ECgene: DYNC2LI1 Kegg: 51626 H-InvDB: DYNC2LI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNC2LI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYNC2LI1 gene:
    Search GeneIP for patents involving DYNC2LI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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