Aliases for DYNC2H1 Gene
Aliases for DYNC2H1 Gene
External Ids for DYNC2H1 Gene
- HGNC: 2962
- Entrez Gene: 79659
- Ensembl: ENSG00000187240
- OMIM: 603297
- UniProtKB: Q8NCM8
Previous HGNC Symbols for DYNC2H1 Gene
- DNCH2
Previous GeneCards Identifiers for DYNC2H1 Gene
- GC11P102487
- GC11P102980
- GC11P098908
Summaries for DYNC2H1 Gene
-
This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
GeneCards Summary for DYNC2H1 Gene
DYNC2H1 (Dynein Cytoplasmic 2 Heavy Chain 1) is a Protein Coding gene. Diseases associated with DYNC2H1 include Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly and Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly. Among its related pathways are Organelle biogenesis and maintenance and Salmonella infection (KEGG). GO annotations related to this gene include ATPase activity and motor activity. An important paralog of this gene is DYNC1H1.
UniProtKB/Swiss-Prot for DYNC2H1 Gene
-
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC2H1 Gene
Genomics for DYNC2H1 Gene
Regulatory Elements for DYNC2H1 Gene
Enhancers for DYNC2H1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around DYNC2H1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for DYNC2H1 Gene
- Chromosome:
- 11
- Start:
- 103,109,431 bp from pter
- End:
- 103,479,863 bp from pter
- Size:
- 370,433 bases
- Orientation:
- Plus strand
Genomic View for DYNC2H1 Gene
Genes around DYNC2H1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q22.3 by Ensembl
- 11q22.3 by Entrez Gene
- 11q22.3 by HGNC
DYNC2H1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DYNC2H1 Gene
Proteins for DYNC2H1 Gene
-
Protein details for DYNC2H1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCM8-DYHC2_HUMAN
- Recommended name:
- Cytoplasmic dynein 2 heavy chain 1
- Protein Accession:
- Q8NCM8
- O00432
- Q16693
- Q3C1U8
- Q4AC93
- Q6ZMX7
- Q6ZUM6
- Q7Z363
- Q8N977
- Q92815
- Q9HAE4
Protein attributes for DYNC2H1 Gene
- Size:
- 4307 amino acids
- Molecular mass:
- 492622 Da
- Quaternary structure:
-
- The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.
- SequenceCaution:
-
- Sequence=BAB13905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04578.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DYNC2H1 Gene
Post-translational modifications for DYNC2H1 Gene
Other Protein References for DYNC2H1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DYNC2H1
-
Abcam antibodies for DYNC2H1
- Invitrogen Antibodies for DYNC2H1
- Search GeneTex for Antibodies for DYNC2H1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DYNC2H1
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- Novus Biologicals proteins for DYNC2H1
- Search GeneTex for Proteins for DYNC2H1
Assay Products
- antibodies-online Kits for DYNC2H1: See all 7
No data available for DME Specific Peptides for DYNC2H1 Gene
Domains & Families for DYNC2H1 Gene
Gene Families for DYNC2H1 Gene
Protein Domains for DYNC2H1 Gene
Suggested Antigen Peptide Sequences for DYNC2H1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NCM8- Family:
-
- Belongs to the dynein heavy chain family.
Function for DYNC2H1 Gene
Molecular function for DYNC2H1 Gene
- UniProtKB/Swiss-Prot Function:
- May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003774 | motor activity | NAS | 8666668 |
| GO:0003777 | microtubule motor activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016887 | ATPase activity | IEA | -- |
Phenotypes for DYNC2H1 Gene
- MGI mutant phenotypes for DYNC2H1:
-
inferred from 6 alleles
- cellular phenotype
- mortality/aging
- growth/size/body region phenotype
- nervous system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- embryo phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for DYNC2H1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for DYNC2H1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYNC2H1 gene
- Search ViGene Biosciences for DYNC2H1
CRISPR Products
-
OriGene CRISPR knockouts for DYNC2H1
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miRNA for DYNC2H1 Gene
- miRTarBase miRNAs that target DYNC2H1
miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- Addgene plasmids for DYNC2H1
- VectorBuilder custom plasmid, inducible vectors for DYNC2H1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYNC2H1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for DYNC2H1
-
ViGene Biosciences adenoviral particle packaged cDNA for DYNC2H1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DYNC2H1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DYNC2H1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNC2H1 Gene
Localization for DYNC2H1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DYNC2H1 Gene
- Cytoplasm, cytoskeleton, cilium axoneme. Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes to the apical cytoplasm (By similarity). According to PubMed:8666668, it localizes to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (PubMed:8666668). {ECO:0000250 UniProtKB:Q9JJ79, ECO:0000269 PubMed:8666668}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| golgi apparatus | 5 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | 8666668 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA,IDA | 21525035 |
Pathways & Interactions for DYNC2H1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Organelle biogenesis and maintenance | ||
| 2 | Signaling by Hedgehog | ||
| 3 | Phagosome | ||
| 4 | Salmonella infection (KEGG) | ||
| 5 | Vasopressin-regulated water reabsorption | ||
Pathways by source for DYNC2H1 Gene
6 Reactome pathways for DYNC2H1 Gene
3 KEGG pathways for DYNC2H1 Gene
Interacting Proteins for DYNC2H1 Gene
Selected Interacting proteins:
ENSP00000381167
Q8NCM8-DYHC2_HUMAN
for DYNC2H1 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007018 | microtubule-based movement | IEA | -- |
| GO:0007030 | Golgi organization | IDA | 8666668 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007368 | determination of left/right symmetry | IEA | -- |
No data available for SIGNOR curated interactions for DYNC2H1 Gene
Transcripts for DYNC2H1 Gene
mRNA/cDNA for DYNC2H1 Gene
- (7) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DYNC2H1 Gene
- Dynein, cytoplasmic 2, heavy chain 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for DYNC2H1
- GenScript: Design CRISPR guide RNA sequences for DYNC2H1
miRNA Products
- Search ViGene Biosciences for DYNC2H1
Inhibitory RNA Products
- Origene RNAi, mouse_rna, siRNA, and shRNA products in human, mouse, rat for DYNC2H1
- Browse OriGene Inhibitory RNA Products For DYNC2H1
-
ViGene Biosciences ready-to-package AAV shRNAs for DYNC2H1 gene
Clone Products
- Addgene plasmids for DYNC2H1
- VectorBuilder custom plasmid, inducible vectors for DYNC2H1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYNC2H1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for DYNC2H1 Gene
This gene is overexpressed in NK cells (37.2) and Monocytes (13.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYNC2H1 Gene
NURSA nuclear receptor signaling pathways regulating expression of DYNC2H1 Gene:
DYNC2H1SOURCE GeneReport for Unigene cluster for DYNC2H1 Gene:
Hs.503721Primer Products
-
OriGene qPCR primer pairs for DYNC2H1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DYNC2H1 Gene
Orthologs for DYNC2H1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DYNC2H1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | DYNC2H1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DYNC2H1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DYNC2H1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DYNC2H1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dync2h1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dync2h1 34 |
|
||
| chicken (Gallus gallus) |
Aves | DYNC2H1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DYNC2H1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dync2h1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | DYNC2H1 (2 of 2) 35 |
|
OneToMany | |
| CABZ01078919.1 35 |
|
OneToMany | |||
| LOC100332402 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1843 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | btv 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | che-3 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DYN1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for DYNC2H1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DYNC2H1 Gene
Paralogs for DYNC2H1 Gene
(8) SIMAP similar genes for DYNC2H1 Gene using alignment to 4 proteins:
Variants for DYNC2H1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs137853025 | Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091], Pathogenic | 103,177,652(+) | GGAGA(A/T)TGTTA | reference, missense | |
| rs137853027 | Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091], Pathogenic | 103,220,720(+) | TAGAG(A/G)TATTC | reference, missense | |
| rs137853028 | Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091], Pathogenic | 103,155,476(+) | TACAA(C/T)TGTAG | reference, missense | |
| rs137853030 | Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091], Pathogenic | 103,125,197(+) | AAGTT(C/T)GTCAG | reference, missense | |
| rs137853031 | Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091], Pathogenic | 103,185,032(+) | GTCAC(A/G)TTTGG | reference, missense |
Residual Variation Intolerance Score:
55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.15;
96.95% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for DYNC2H1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNC2H1 Gene
Disorders for DYNC2H1 Gene
(11) MalaCards diseases for DYNC2H1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| short-rib thoracic dysplasia 3 with or without polydactyly |
|
|
| short-rib thoracic dysplasia 6 with or without polydactyly |
|
|
| short-rib thoracic dysplasia 1 with or without polydactyly |
|
|
| polydactyly |
|
|
| achondrogenesis, type ii or hypochondrogenesis |
|
|
Search DYNC2H1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DYHC2_HUMAN- Short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) [MIM:613091]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a trident appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome. {ECO:0000269 PubMed:19361615, ECO:0000269 PubMed:19442771, ECO:0000269 PubMed:22499340, ECO:0000269 PubMed:23456818}. Note=The disease is caused by mutations affecting the gene represented in this entry. In some cases DYNC2H1 mutations result in disease phenotype in the presence of mutations in NEK1 indicating digenic inheritance (digenic short rib-polydactyly syndrome 3/6 with polydactyly) (PubMed:21211617). {ECO:0000269 PubMed:21211617}.
Relevant External Links for DYNC2H1
No data available for Genatlas for DYNC2H1 Gene
Publications for DYNC2H1 Gene
- Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome. (PMID: 19361615) Merrill A.E. … Krakow D. (Am. J. Hum. Genet. 2009) 3 4 22 64
- DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type III. (PMID: 19442771) Dagoneau N. … Cormier-Daire V. (Am. J. Hum. Genet. 2009) 3 4 22 64
- Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. (PMID: 9373155) Neesen J. … Schmid M. (Gene 1997) 2 3 4 64
- Exome sequencing identifies DYNC2H1 mutations as a common cause of asphyxiating thoracic dystrophy (Jeune syndrome) without major polydactyly, renal or retinal involvement. (PMID: 23456818) Schmidts M. … Mitchison H.M. (J. Med. Genet. 2013) 3 4 64
- NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases. (PMID: 22499340) El Hokayem J. … Cormier-Daire V. (J. Med. Genet. 2012) 3 4 64
Products for DYNC2H1 Gene
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- VectorBuilder custom plasmid, inducible vectors for DYNC2H1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DYNC2H1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DYNC2H1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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