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Aliases for DYNC1LI2 Gene

Aliases for DYNC1LI2 Gene

  • Dynein Cytoplasmic 1 Light Intermediate Chain 2 2 3 5
  • Dynein, Cytoplasmic, Light Intermediate Polypeptide 2 2 3
  • Dynein Light Intermediate Chain 2, Cytosolic 3 4
  • LIC53/55 3 4
  • DNCLI2 3 4
  • LIC-2 3 4
  • LIC2 3 4
  • Cytoplasmic Dynein 1 Light Intermediate Chain 2 3

External Ids for DYNC1LI2 Gene

Previous HGNC Symbols for DYNC1LI2 Gene

  • DNCLI2

Previous GeneCards Identifiers for DYNC1LI2 Gene

  • GC16M065314
  • GC16M052629

Summaries for DYNC1LI2 Gene

Entrez Gene Summary for DYNC1LI2 Gene

  • Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]

GeneCards Summary for DYNC1LI2 Gene

DYNC1LI2 (Dynein Cytoplasmic 1 Light Intermediate Chain 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI1.

UniProtKB/Swiss-Prot for DYNC1LI2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene Wiki entry for DYNC1LI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1LI2 Gene

Genomics for DYNC1LI2 Gene

Regulatory Elements for DYNC1LI2 Gene

Enhancers for DYNC1LI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F066716 0.6 ENCODE 11.7 +34.0 34012 1.9 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF766 ZNF143 ZNF207 TERB1 LOC106699570 DYNC1LI2 CMTM4 ENSG00000260465 GC16M066696
GH16F066714 0.2 ENCODE 11.1 +36.9 36913 1.4 ZFP37 PRDM10 PRDM1 DYNC1LI2 LOC106699570 CA7 BEAN1 TERB1 CMTM3 ENSG00000260465 GC16M066696
GH16F066649 0.2 ENCODE 10.9 +101.8 101787 1.0 ZNF692 MAFK CMTM4 DYNC1LI2 LOC106699570 TK2 GC16P066646 GC16M066667
GH16F066650 0.7 Ensembl ENCODE 10.9 +99.2 99219 4.0 ATF1 PKNOX1 ARID4B FEZF1 ZNF2 ZNF121 GATA2 ZNF143 YY2 KAT8 CMTM4 BEAN1 TK2 LOC106699570 DYNC1LI2 CMTM3 GC16P066646 GC16M066667
GH16F066659 0.5 Ensembl ENCODE 10.4 +90.3 90309 3.0 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 SLC30A9 CBX5 BEAN1 CMTM4 CA7 DYNC1LI2 LOC106699570 CES2 TK2 GC16M066667 GC16P066646
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Promoters for DYNC1LI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149107 398 2001 CREB3L1 SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 ZNF207 SP3 REST

Genomic Location for DYNC1LI2 Gene

Chromosome:
16
Start:
66,720,893 bp from pter
End:
66,751,798 bp from pter
Size:
30,906 bases
Orientation:
Minus strand

Genomic View for DYNC1LI2 Gene

Genes around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNC1LI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNC1LI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1LI2 Gene

Proteins for DYNC1LI2 Gene

  • Protein details for DYNC1LI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43237-DC1L2_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 2
    Protein Accession:
    O43237
    Secondary Accessions:
    • A8K6V1
    • B4DZP4
    • Q8TAT3

    Protein attributes for DYNC1LI2 Gene

    Size:
    492 amino acids
    Molecular mass:
    54099 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).

    Alternative splice isoforms for DYNC1LI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNC1LI2 Gene

Post-translational modifications for DYNC1LI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYNC1LI2 Gene

Domains & Families for DYNC1LI2 Gene

Gene Families for DYNC1LI2 Gene

Graphical View of Domain Structure for InterPro Entry

O43237

UniProtKB/Swiss-Prot:

DC1L2_HUMAN :
  • Belongs to the dynein light intermediate chain family.
Family:
  • Belongs to the dynein light intermediate chain family.
genes like me logo Genes that share domains with DYNC1LI2: view

Function for DYNC1LI2 Gene

Molecular function for DYNC1LI2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene Ontology (GO) - Molecular Function for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0045504 dynein heavy chain binding IBA --
genes like me logo Genes that share ontologies with DYNC1LI2: view
genes like me logo Genes that share phenotypes with DYNC1LI2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNC1LI2 Gene

Localization for DYNC1LI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1LI2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNC1LI2 Gene COMPARTMENTS Subcellular localization image for DYNC1LI2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005868 cytoplasmic dynein complex IEA,IBA --
genes like me logo Genes that share ontologies with DYNC1LI2: view

Pathways & Interactions for DYNC1LI2 Gene

genes like me logo Genes that share pathways with DYNC1LI2: view

Gene Ontology (GO) - Biological Process for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA,IBA --
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007018 microtubule-based movement IEA,IBA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DYNC1LI2: view

No data available for SIGNOR curated interactions for DYNC1LI2 Gene

Transcripts for DYNC1LI2 Gene

Unigene Clusters for DYNC1LI2 Gene

Dynein, cytoplasmic 1, light intermediate chain 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6: - - -
SP7: -
SP8:

Relevant External Links for DYNC1LI2 Gene

GeneLoc Exon Structure for
DYNC1LI2
ECgene alternative splicing isoforms for
DYNC1LI2

Expression for DYNC1LI2 Gene

mRNA expression in normal human tissues for DYNC1LI2 Gene

mRNA differential expression in normal tissues according to GTEx for DYNC1LI2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for DYNC1LI2 Gene

This gene is overexpressed in Fetal Brain (7.0) and Cervix (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYNC1LI2 Gene



Protein tissue co-expression partners for DYNC1LI2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYNC1LI2 Gene:

DYNC1LI2

SOURCE GeneReport for Unigene cluster for DYNC1LI2 Gene:

Hs.369068
genes like me logo Genes that share expression patterns with DYNC1LI2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DYNC1LI2 Gene

Orthologs for DYNC1LI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1LI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNC1LI2 34 35
  • 97.87 (n)
cow
(Bos Taurus)
Mammalia DYNC1LI2 34 35
  • 93.9 (n)
dog
(Canis familiaris)
Mammalia DYNC1LI2 34 35
  • 93.27 (n)
rat
(Rattus norvegicus)
Mammalia Dync1li2 34
  • 91.98 (n)
mouse
(Mus musculus)
Mammalia Dync1li2 34 16 35
  • 90.45 (n)
oppossum
(Monodelphis domestica)
Mammalia DYNC1LI2 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1LI2 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNC1LI2 34 35
  • 81.31 (n)
-- 35
  • 77 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DYNC1LI2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dync1li2 34
  • 73.58 (n)
zebrafish
(Danio rerio)
Actinopterygii dync1li2 34 35
  • 70.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000723 34
  • 54.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dlic 34 35
  • 52.61 (n)
worm
(Caenorhabditis elegans)
Secernentea dli-1 34 35
  • 48.19 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1475 34
Species where no ortholog for DYNC1LI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1LI2 Gene

ENSEMBL:
Gene Tree for DYNC1LI2 (if available)
TreeFam:
Gene Tree for DYNC1LI2 (if available)

Paralogs for DYNC1LI2 Gene

Paralogs for DYNC1LI2 Gene

genes like me logo Genes that share paralogs with DYNC1LI2: view

Variants for DYNC1LI2 Gene

Sequence variations from dbSNP and Humsavar for DYNC1LI2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10671755 -- 66,747,082(+) CAACA(-/T/TT/TTT)TTTTT intron-variant
rs10990 -- 66,727,713(-) TCAGT(A/G)AAAAA nc-transcript-variant, reference, synonymous-codon
rs11075642 -- 66,728,844(+) GCAGG(C/T)AGGTG intron-variant
rs111420970 -- 66,729,839(+) TGCAG(G/T)GGCGC intron-variant
rs111508783 -- 66,732,994(+) CCACC(A/C)CAGGG intron-variant

Variation tolerance for DYNC1LI2 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNC1LI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNC1LI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DYNC1LI2 Gene

Disorders for DYNC1LI2 Gene

Relevant External Links for DYNC1LI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNC1LI2

No disorders were found for DYNC1LI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNC1LI2 Gene

Publications for DYNC1LI2 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DYNC1LI2 Gene

Sources for DYNC1LI2 Gene

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