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DYNC1LI2 Gene

protein-coding   GIFtS: 57
GCID: GC16M066754

Dynein, Cytoplasmic 1, Light Intermediate Chain 2

(Previous names: dynein, cytoplasmic, light intermediate polypeptide 2)
(Previous symbol: DNCLI2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Cytoplasmic 1, Light Intermediate Chain 21 2     LIC-22 3
DNCLI21 2 3     LIC22 3
Dynein, Cytoplasmic, Light Intermediate Polypeptide 21 2     LIC53/552 3
Dynein Light Intermediate Chain 2, Cytosolic2 3     Cytoplasmic Dynein 1 Light Intermediate Chain 22

External Ids:    HGNC: 29661   Entrez Gene: 17832   Ensembl: ENSG000001357207   OMIM: 6114065   UniProtKB: O432373   

Export aliases for DYNC1LI2 gene to outside databases

Previous GC identifers: GC16M065314 GC16M052629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYNC1LI2 Gene:
Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 (PubMed 7738094)). See DYNC1H1
(MIM 600112) for general information about dyneins.(supplied by OMIM, Mar 2008)

GeneCards Summary for DYNC1LI2 Gene:
DYNC1LI2 (dynein, cytoplasmic 1, light intermediate chain 2) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI1.

UniProtKB/Swiss-Prot: DC1L2_HUMAN, O43237
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules. May play a role in binding dynein to membranous organelles or chromosomes

Gene Wiki entry for DYNC1LI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNC1LI2 gene promoter:
         CUTL1   NF-AT   NF-AT4   NF-AT2   HSF2   AP-2beta   NF-AT3   AP-2alpha   NF-AT1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNC1LI2 promoter sequence
   Search Chromatin IP Primers for DYNC1LI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNC1LI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

DYNC1LI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNC1LI2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M066754:  view genomic region     (about GC identifiers)

Start:
66,754,796 bp from pter      End:
66,785,701 bp from pter
Size:
30,906 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DC1L2_HUMAN, O43237 (See protein sequence)
Recommended Name: Cytoplasmic dynein 1 light intermediate chain 2  
Size: 492 amino acids; 54099 Da
Subunit: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs)
and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs)
and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy
chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic
subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates.
Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity)
Secondary accessions: A8K6V1 Q8TAT3

Explore the universe of human proteins at neXtProt for DYNC1LI2: NX_O43237

Explore proteomics data for DYNC1LI2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DYNC1LI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273086.1  NP_006132.1  

    ENSEMBL proteins: 
     ENSP00000258198   ENSP00000394289   ENSP00000462434   ENSP00000462017   ENSP00000462224  
     ENSP00000408566   ENSP00000457707   ENSP00000457464   ENSP00000463124   ENSP00000368795  
    Reactome Protein details: O43237

    DYNC1LI2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DYNC1LI2

     
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    antibodies-online proteins for DYNC1LI2 (7 products) 

     
    antibodies-online peptides for DYNC1LI2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR022780 Dynein_light_int_chain
     IPR008467 Dynein1_light_intermed_chain

    Graphical View of Domain Structure for InterPro Entry O43237

    ProtoNet protein and cluster: O43237

    1 Blocks protein domain: IPB008467 Dynein light intermediate chain

    UniProtKB/Swiss-Prot: DC1L2_HUMAN, O43237
    Similarity: Belongs to the dynein light intermediate chain family


    Find genes that share domains with DYNC1LI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DC1L2_HUMAN, O43237
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules. May play a role in binding dynein to membranous organelles or chromosomes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DYNC1LI2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DYNC1LI2:
     Decreased number of cells in m  Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DYNC1LI2

    miRNA
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    miRTarBase miRNAs that target DYNC1LI2:
    hsa-let-7f-5p (MIRT051385), hsa-mir-21-5p (MIRT030895), hsa-mir-3676-3p (MIRT052871)

    Block miRNA regulation of human, mouse, rat DYNC1LI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DYNC1LI2 (see all 61):
    hsa-miR-548j hsa-miR-15a hsa-miR-106a hsa-miR-218-1* hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDYNC1LI2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DC1L2_HUMAN, O43237: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    endosome2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005868cytoplasmic dynein complex IEA--
    GO:0005874microtubule IEA--

    Find genes that share ontologies with DYNC1LI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYNC1LI2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    4Salmonella infection (KEGG)
    Salmonella infection0.30
    5Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption


    Find genes that share SuperPaths with DYNC1LI2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DYNC1LI2
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF

    1 Reactome Pathway for DYNC1LI2
        MHC class II antigen presentation


    3 Kegg Pathways  (Kegg details for DYNC1LI2):
        Phagosome
    Vasopressin-regulated water reabsorption
    Salmonella infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYNC1LI2
    Interactions:

        Search GeneGlobe Interaction Network for DYNC1LI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNC1LI2 (O432372, 3 ENSP000002581984) via UniProtKB, MINT, STRING, and/or I2D (see all 842)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNC1H1Q142042, 3, ENSP000003489654MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000348965
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    DCTN2Q135612, ENSP000004089104MINT-7945693 MINT-7947479 STRING: ENSP00000408910
    ELAVL1Q157172, ENSP000003852694MINT-7945693 MINT-7947479 STRING: ENSP00000385269
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0006810transport IEA--
    GO:0007018microtubule-based movement IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--
    GO:0051642centrosome localization IEA--

    Find genes that share ontologies with DYNC1LI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYNC1LI2 (DC1L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DYNC1LI2 gene (2 alternative transcripts): 
    NM_001286157.1  NM_006141.2  

    Unigene Cluster for DYNC1LI2:

    Dynein, cytoplasmic 1, light intermediate chain 2
    Hs.369068  [show with all ESTs]
    Unigene Representative Sequence: NM_006141
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258198(uc002eqb.1 uc010vis.1) ENST00000443351 ENST00000563628
    ENST00000569320 ENST00000564559 ENST00000567499 ENST00000568453 ENST00000564833
    ENST00000565532 ENST00000570201 ENST00000440564(uc010vit.2 uc010viu.2)
    ENST00000561727 ENST00000566150 ENST00000568180 ENST00000564090 ENST00000379482

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    hsa-miR-548j hsa-miR-15a hsa-miR-106a hsa-miR-218-1* hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDYNC1LI2 3' UTR sequence
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    Additional mRNA sequence: 

    AF035812.1 AK024863.1 AK095237.1 AK291766.1 AK295049.1 AK303031.1 AK304233.1 AL834400.1 
    BC010928.1 BC022934.1 BC025959.1 BC036633.2 BC069056.1 BX648863.1 

    16 DOTS entries:

    DT.100827470  DT.91675447  DT.100827468  DT.75178535  DT.120663657  DT.95168980  DT.86839936  DT.97833330 
    DT.100827471  DT.99929717  DT.100037991  DT.120663720  DT.91956853  DT.95168979  DT.99985049  DT.120663619 

    Selected AceView cDNA sequences (see all 664):

    AL710275 CN482921 BQ055341 AI985874 BE549763 BM718415 N48889 AW589495 
    BM679433 AW182550 AA700624 AW005344 AI016185 AA363613 BX475240 AI391621 
    AI431609 AA662152 AA351576 W73764 BM702738 T05147 BE902561 AA894851 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI2 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:        -                                                                 -     -     -           -                                             
    SP2:                                                                                                                                                
    SP3:                                                                                                  -                                             
    SP4:        -                       -                                                                                                               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for DYNC1LI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYNC1LI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAACCTTG
    DYNC1LI2 Expression
    About this image

    DYNC1LI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNC1LI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369068
        Custom PCR Arrays for DYNC1LI2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNC1LI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DYNC1LI2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dync1li21 , 5 dynein, cytoplasmic 1 light intermediate chain 21, 5 90.45(n)1
    96.95(a)1
      8 (53.04 cM)5
    2346631  NM_001013380.21  NP_001013398.21 
     1044176745 
    chicken
    (Gallus gallus)
    Aves DYNC1LI21 dynein, cytoplasmic 1, light intermediate chain 2 81.31(n)
    89.53(a)
      415793  NM_001030573.1  NP_001025744.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYNC1LI26
    dynein, cytoplasmic 1, light intermediate chain 2
    77(a)
    1 ↔ 1
    GL343295.1(139651-169738)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dync1li21 dynein, cytoplasmic 1, light intermediate chain 2 73.58(n)
    81.95(a)
      100498465  XM_002933651.2  XP_002933697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dync1li21 dynein, cytoplasmic 1, light intermediate chain 2 70.32(n)
    76.24(a)
      573266  NM_001017669.1  NP_001017669.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dlic1 Dynein light intermediate chain 52.61(n)
    48.64(a)
      32057  NM_167274.1  NP_727501.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dli-11 dli-1 48.19(n)
    37.35(a)
      178260  NM_070117.7  NP_502518.2 


    ENSEMBL Gene Tree for DYNC1LI2 (if available)
    TreeFam Gene Tree for DYNC1LI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYNC1LI2 gene
    DYNC1LI12  
    3 SIMAP similar genes for DYNC1LI2 using alignment to 10 protein entries:     DC1L2_HUMAN (see all proteins):
    DKFZp686J08252    DKFZp686A1525    DYNC1LI1

    Find genes that share paralogs with DYNC1LI2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYNC1LI2 (see all 645)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180862321,2
    F--66754398(+) AGATAT/CATAAA 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1912725121,2
    --66754501(+) AAAAAC/TCAAAA 1 -- ds50010--------
    rs1839985471,2
    --66754504(+) AACCAA/GAAAAA 1 -- ds50010--------
    rs793332951,2
    C,F--66754576(+) AACCAC/GTGGAG 1 -- ds50013Minor allele frequency- G:0.07CSA WA 120
    rs1868662321,2
    --66754774(+) ATTCAC/TCATAA 1 -- ds50010--------
    rs1486715311,2
    C--66754814(+) GGATTC/TGTGTT 1 -- ut310--------
    rs115536821,2
    C--66754853(+) TTTTTC/TCCAGG 1 -- ut31 trp31Minor allele frequency- T:0.00NA 2
    rs1421053861,2
    --66755022(+) ACATTC/GTTAAG 1 -- ut310--------
    rs1921535101,2
    --66755027(+) GTTAAA/GGTCAT 1 -- ut310--------
    rs1511796971,2
    C--66755028(+) TTAAGA/GTCATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DYNC1LI2 (66754796 - 66785701 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYNC1LI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906786CNV Loss21882294
    dgv2885n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYNC1LI2
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNC1LI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611406    OMIM disorders: --


    Find genes that share disorders with DYNC1LI2           About GenesLikeMe


    Export disorders for DYNC1LI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYNC1LI2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DYNC1LI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (J. Cell Biol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. (PubMed id 21169557)1 Tan S.C....Vallee R.B. (Mol. Biol. Cell 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1783 HGNC: 2966 AceView: DNCLI2 Ensembl:ENSG00000135720 euGenes: HUgn1783
    ECgene: DYNC1LI2 Kegg: 1783 H-InvDB: DYNC1LI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNC1LI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYNC1LI2 gene:
    Search GeneIP for patents involving DYNC1LI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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