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Aliases for DYNC1LI2 Gene

Aliases for DYNC1LI2 Gene

  • Dynein Cytoplasmic 1 Light Intermediate Chain 2 2 3
  • Dynein, Cytoplasmic, Light Intermediate Polypeptide 2 2 3
  • Dynein, Cytoplasmic 1, Light Intermediate Chain 2 3 5
  • Dynein Light Intermediate Chain 2, Cytosolic 3 4
  • LIC53/55 3 4
  • DNCLI2 3 4
  • LIC-2 3 4
  • LIC2 3 4

External Ids for DYNC1LI2 Gene

Previous HGNC Symbols for DYNC1LI2 Gene

  • DNCLI2

Previous GeneCards Identifiers for DYNC1LI2 Gene

  • GC16M065314
  • GC16M052629

Summaries for DYNC1LI2 Gene

Entrez Gene Summary for DYNC1LI2 Gene

  • Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]

GeneCards Summary for DYNC1LI2 Gene

DYNC1LI2 (Dynein Cytoplasmic 1 Light Intermediate Chain 2) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Immune System. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI1.

UniProtKB/Swiss-Prot for DYNC1LI2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene Wiki entry for DYNC1LI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1LI2 Gene

Genomics for DYNC1LI2 Gene

Regulatory Elements for DYNC1LI2 Gene

Enhancers for DYNC1LI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Promoters for DYNC1LI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DYNC1LI2 Gene

Chromosome:
16
Start:
66,720,893 bp from pter
End:
66,751,798 bp from pter
Size:
30,906 bases
Orientation:
Minus strand

Genomic View for DYNC1LI2 Gene

Genes around DYNC1LI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNC1LI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNC1LI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1LI2 Gene

Proteins for DYNC1LI2 Gene

  • Protein details for DYNC1LI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43237-DC1L2_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 2
    Protein Accession:
    O43237
    Secondary Accessions:
    • A8K6V1
    • B4DZP4
    • Q8TAT3

    Protein attributes for DYNC1LI2 Gene

    Size:
    492 amino acids
    Molecular mass:
    54099 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).

    Alternative splice isoforms for DYNC1LI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNC1LI2 Gene

Proteomics data for DYNC1LI2 Gene at MOPED

Post-translational modifications for DYNC1LI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DYNC1LI2

No data available for DME Specific Peptides for DYNC1LI2 Gene

Domains & Families for DYNC1LI2 Gene

Gene Families for DYNC1LI2 Gene

Protein Domains for DYNC1LI2 Gene

Graphical View of Domain Structure for InterPro Entry

O43237

UniProtKB/Swiss-Prot:

DC1L2_HUMAN :
  • Belongs to the dynein light intermediate chain family.
Family:
  • Belongs to the dynein light intermediate chain family.
genes like me logo Genes that share domains with DYNC1LI2: view

Function for DYNC1LI2 Gene

Molecular function for DYNC1LI2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Gene Ontology (GO) - Molecular Function for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with DYNC1LI2: view
genes like me logo Genes that share phenotypes with DYNC1LI2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNC1LI2 Gene

Localization for DYNC1LI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1LI2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNC1LI2 Gene COMPARTMENTS Subcellular localization image for DYNC1LI2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005868 cytoplasmic dynein complex IEA --
genes like me logo Genes that share ontologies with DYNC1LI2: view

Pathways & Interactions for DYNC1LI2 Gene

genes like me logo Genes that share pathways with DYNC1LI2: view

Gene Ontology (GO) - Biological Process for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008152 metabolic process IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DYNC1LI2: view

No data available for SIGNOR curated interactions for DYNC1LI2 Gene

Drugs & Compounds for DYNC1LI2 Gene

No Compound Related Data Available

Transcripts for DYNC1LI2 Gene

Unigene Clusters for DYNC1LI2 Gene

Dynein, cytoplasmic 1, light intermediate chain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6: - - -
SP7: -
SP8:

Relevant External Links for DYNC1LI2 Gene

GeneLoc Exon Structure for
DYNC1LI2
ECgene alternative splicing isoforms for
DYNC1LI2

Expression for DYNC1LI2 Gene

mRNA expression in normal human tissues for DYNC1LI2 Gene

mRNA differential expression in normal tissues according to GTEx for DYNC1LI2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for DYNC1LI2 Gene

This gene is overexpressed in Fetal Brain (7.0) and Cervix (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNC1LI2 Gene



SOURCE GeneReport for Unigene cluster for DYNC1LI2 Gene Hs.369068

genes like me logo Genes that share expression patterns with DYNC1LI2: view

Protein tissue co-expression partners for DYNC1LI2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DYNC1LI2 Gene

Orthologs for DYNC1LI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1LI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DYNC1LI2 35
  • 93.9 (n)
  • 98.37 (a)
DYNC1LI2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNC1LI2 35
  • 93.27 (n)
  • 98.03 (a)
DYNC1LI2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dync1li2 35
  • 90.45 (n)
  • 96.95 (a)
Dync1li2 16
Dync1li2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYNC1LI2 35
  • 97.87 (n)
  • 97.65 (a)
DYNC1LI2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dync1li2 35
  • 91.98 (n)
  • 97.28 (a)
oppossum
(Monodelphis domestica)
Mammalia DYNC1LI2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1LI2 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNC1LI2 35
  • 81.31 (n)
  • 89.53 (a)
-- 36
  • 77 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
DYNC1LI2 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DYNC1LI2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dync1li2 35
  • 73.58 (n)
  • 81.95 (a)
zebrafish
(Danio rerio)
Actinopterygii dync1li2 35
  • 70.32 (n)
  • 76.24 (a)
dync1li2 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000723 35
  • 54.44 (n)
  • 52.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dlic 35
  • 52.61 (n)
  • 48.64 (a)
Dlic 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dli-1 35
  • 48.19 (n)
  • 37.35 (a)
dli-1 36
  • 31 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1475 35
Species with no ortholog for DYNC1LI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1LI2 Gene

ENSEMBL:
Gene Tree for DYNC1LI2 (if available)
TreeFam:
Gene Tree for DYNC1LI2 (if available)

Paralogs for DYNC1LI2 Gene

Paralogs for DYNC1LI2 Gene

genes like me logo Genes that share paralogs with DYNC1LI2: view

Variants for DYNC1LI2 Gene

Sequence variations from dbSNP and Humsavar for DYNC1LI2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10990 -- 66,727,713(-) TCAGT(A/G)AAAAA nc-transcript-variant, reference, synonymous-codon
rs4078027 -- 66,751,978(-) GCCTA(A/G)GCTTT upstream-variant-2KB
rs4321191 -- 66,752,961(+) AGAGA(A/G)TACCA upstream-variant-2KB
rs4349137 -- 66,750,884(+) GAGGC(C/T)CAAAG intron-variant
rs4384598 -- 66,748,305(+) aaaaa(A/T)CTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNC1LI2 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294
dgv2885n71 CNV Loss 21882294

Variation tolerance for DYNC1LI2 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DYNC1LI2 Gene

Disorders for DYNC1LI2 Gene

Relevant External Links for DYNC1LI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNC1LI2

No disorders were found for DYNC1LI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNC1LI2 Gene

Publications for DYNC1LI2 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 67
  2. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  3. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. (PMID: 25818806) Malikov V. … Naghavi M.H. (Nat Commun 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DYNC1LI2 Gene

Sources for DYNC1LI2 Gene

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