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Aliases for DYNC1LI2 Gene

Aliases for DYNC1LI2 Gene

  • Dynein, Cytoplasmic 1, Light Intermediate Chain 2 2 3
  • Dynein, Cytoplasmic, Light Intermediate Polypeptide 2 2 3
  • Dynein Light Intermediate Chain 2, Cytosolic 3 4
  • LIC53/55 3 4
  • DNCLI2 3 4
  • LIC-2 3 4
  • LIC2 3 4
  • Cytoplasmic Dynein 1 Light Intermediate Chain 2 3

External Ids for DYNC1LI2 Gene

Previous Symbols for DYNC1LI2 Gene

  • DNCLI2

Summaries for DYNC1LI2 Gene

Entrez Gene Summary for DYNC1LI2 Gene

  • Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]

GeneCards Summary for DYNC1LI2 Gene

DYNC1LI2 (Dynein, Cytoplasmic 1, Light Intermediate Chain 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Salmonella infection (KEGG). GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI1.

UniProtKB/Swiss-Prot for DYNC1LI2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes

Gene Wiki entry for DYNC1LI2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1LI2 Gene

Genomics for DYNC1LI2 Gene

Genomic Location for DYNC1LI2 Gene

Start:
66,720,893 bp from pter
End:
66,751,798 bp from pter
Size:
30,906 bases
Orientation:
Minus strand

Genomic View for DYNC1LI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNC1LI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1LI2 Gene

Regulatory Elements for DYNC1LI2 Gene

Proteins for DYNC1LI2 Gene

  • Protein details for DYNC1LI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43237-DC1L2_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 2
    Protein Accession:
    O43237
    Secondary Accessions:
    • A8K6V1
    • B4DZP4
    • Q8TAT3

    Protein attributes for DYNC1LI2 Gene

    Size:
    492 amino acids
    Molecular mass:
    54099 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).

    Alternative splice isoforms for DYNC1LI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNC1LI2 Gene

Proteomics data for DYNC1LI2 Gene at MOPED

Post-translational modifications for DYNC1LI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNC1LI2 Gene

No data available for DME Specific Peptides for DYNC1LI2 Gene

Domains for DYNC1LI2 Gene

Gene Families for DYNC1LI2 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNC1LI2 Gene

UniProtKB/Swiss-Prot:

DC1L2_HUMAN
Family:
  • Belongs to the dynein light intermediate chain family.:
    • O43237
genes like me logo Genes that share domains with DYNC1LI2: view

Function for DYNC1LI2 Gene

Molecular function for DYNC1LI2 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes

Gene Ontology (GO) - Molecular Function for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DYNC1LI2: view
genes like me logo Genes that share phenotypes with DYNC1LI2: view

miRNA for DYNC1LI2 Gene

miRTarBase miRNAs that target DYNC1LI2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNC1LI2 Gene

Localization for DYNC1LI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1LI2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNC1LI2 Gene COMPARTMENTS Subcellular localization image for DYNC1LI2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
endosome 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005868 cytoplasmic dynein complex IEA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DYNC1LI2: view

Pathways for DYNC1LI2 Gene

genes like me logo Genes that share pathways with DYNC1LI2: view

Pathways by source for DYNC1LI2 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for DYNC1LI2 Gene
2 Reactome pathways for DYNC1LI2 Gene

Gene Ontology (GO) - Biological Process for DYNC1LI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006810 transport IEA --
GO:0007018 microtubule-based movement IEA --
GO:0008152 metabolic process IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DYNC1LI2: view

Transcripts for DYNC1LI2 Gene

Unigene Clusters for DYNC1LI2 Gene

Dynein, cytoplasmic 1, light intermediate chain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6: - - -
SP7: -
SP8:

Relevant External Links for DYNC1LI2 Gene

GeneLoc Exon Structure for
DYNC1LI2
ECgene alternative splicing isoforms for
DYNC1LI2

Expression for DYNC1LI2 Gene

mRNA expression in normal human tissues for DYNC1LI2 Gene

mRNA differential expression in normal tissues according to GTEx for DYNC1LI2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNC1LI2 Gene

SOURCE GeneReport for Unigene cluster for DYNC1LI2 Gene Hs.369068

genes like me logo Genes that share expressions with DYNC1LI2: view

Orthologs for DYNC1LI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1LI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNC1LI2 36
  • 97.87 (n)
  • 97.65 (a)
DYNC1LI2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNC1LI2 36
  • 93.9 (n)
  • 98.37 (a)
DYNC1LI2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNC1LI2 36
  • 93.27 (n)
  • 98.03 (a)
DYNC1LI2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dync1li2 36
  • 90.45 (n)
  • 96.95 (a)
Dync1li2 16
Dync1li2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNC1LI2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1LI2 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dync1li2 36
  • 91.98 (n)
  • 97.28 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 77 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
DYNC1LI2 36
  • 81.31 (n)
  • 89.53 (a)
DYNC1LI2 37
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DYNC1LI2 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dync1li2 36
  • 73.58 (n)
  • 81.95 (a)
zebrafish
(Danio rerio)
Actinopterygii dync1li2 36
  • 70.32 (n)
  • 76.24 (a)
dync1li2 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000723 36
  • 54.44 (n)
  • 52.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dlic 36
  • 52.61 (n)
  • 48.64 (a)
Dlic 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dli-1 36
  • 48.19 (n)
  • 37.35 (a)
dli-1 37
  • 31 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1475 36
Species with no ortholog for DYNC1LI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1LI2 Gene

ENSEMBL:
Gene Tree for DYNC1LI2 (if available)
TreeFam:
Gene Tree for DYNC1LI2 (if available)

Paralogs for DYNC1LI2 Gene

Paralogs for DYNC1LI2 Gene

genes like me logo Genes that share paralogs with DYNC1LI2: view

Variants for DYNC1LI2 Gene

Sequence variations from dbSNP and Humsavar for DYNC1LI2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10990 -- 66,727,713(-) TCAGT(A/G)AAAAA reference, synonymous-codon
rs935760 -- 66,731,934(-) GCTTT(C/G)GCTAT intron-variant
rs1877141 -- 66,739,657(-) TTGAG(A/C)CCAAA intron-variant
rs1975632 -- 66,729,843(-) gattg(C/T)gccac intron-variant
rs2067040 -- 66,730,906(+) CAATG(G/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNC1LI2 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294
dgv2885n71 CNV Loss 21882294

Relevant External Links for DYNC1LI2 Gene

HapMap Linkage Disequilibrium report
DYNC1LI2

Disorders for DYNC1LI2 Gene

No disorders were found for DYNC1LI2 Gene.

No data available for UniProtKB/Swiss-Prot for DYNC1LI2 Gene

Publications for DYNC1LI2 Gene

  1. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DYNC1LI2 Gene

Sources for DYNC1LI2 Gene

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