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Aliases for DYNC1LI1 Gene

Aliases for DYNC1LI1 Gene

  • Dynein, Cytoplasmic 1, Light Intermediate Chain 1 2 3
  • Dynein, Cytoplasmic, Light Intermediate Polypeptide 1 2 3
  • Dynein Light Intermediate Chain 1, Cytosolic 3 4
  • Dynein Light Chain A 3 4
  • DNCLI1 3 4
  • DLC-A 3 4
  • LIC1 3 4
  • Cytoplasmic Dynein 1 Light Intermediate Chain 1 3
  • Dynein Light Chain-A 3

External Ids for DYNC1LI1 Gene

Previous HGNC Symbols for DYNC1LI1 Gene

  • DNCLI1

Summaries for DYNC1LI1 Gene

GeneCards Summary for DYNC1LI1 Gene

DYNC1LI1 (Dynein, Cytoplasmic 1, Light Intermediate Chain 1) is a Protein Coding gene. Among its related pathways are Salmonella infection (KEGG) and Vasopressin-regulated water reabsorption. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI2.

UniProtKB/Swiss-Prot for DYNC1LI1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Gene Wiki entry for DYNC1LI1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1LI1 Gene

Genomics for DYNC1LI1 Gene

Regulatory Elements for DYNC1LI1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DYNC1LI1 Gene

Start:
32,525,971 bp from pter
End:
32,570,874 bp from pter
Size:
44,904 bases
Orientation:
Minus strand

Genomic View for DYNC1LI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNC1LI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1LI1 Gene

Proteins for DYNC1LI1 Gene

  • Protein details for DYNC1LI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6G9-DC1L1_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 1
    Protein Accession:
    Q9Y6G9
    Secondary Accessions:
    • A2RRG7
    • Q53HC8
    • Q53HK7

    Protein attributes for DYNC1LI1 Gene

    Size:
    523 amino acids
    Molecular mass:
    56579 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.

neXtProt entry for DYNC1LI1 Gene

Proteomics data for DYNC1LI1 Gene at MOPED

Post-translational modifications for DYNC1LI1 Gene

Other Protein References for DYNC1LI1 Gene

Antibody Products

No data available for DME Specific Peptides for DYNC1LI1 Gene

Domains for DYNC1LI1 Gene

Gene Families for DYNC1LI1 Gene

HGNC:
  • DYN :Cytoplasmic dyneins

Protein Domains for DYNC1LI1 Gene

Suggested Antigen Peptide Sequences for DYNC1LI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6G9

UniProtKB/Swiss-Prot:

DC1L1_HUMAN :
  • Q9Y6G9
Family:
  • Belongs to the dynein light intermediate chain family.
genes like me logo Genes that share domains with DYNC1LI1: view

Function for DYNC1LI1 Gene

Molecular function for DYNC1LI1 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

Gene Ontology (GO) - Molecular Function for DYNC1LI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DYNC1LI1: view
genes like me logo Genes that share phenotypes with DYNC1LI1: view

Animal Model Products

CRISPR Products

miRNA for DYNC1LI1 Gene

miRTarBase miRNAs that target DYNC1LI1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYNC1LI1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNC1LI1 Gene

Localization for DYNC1LI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1LI1 Gene

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNC1LI1 Gene COMPARTMENTS Subcellular localization image for DYNC1LI1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
endosome 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DYNC1LI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 19229290
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IDA 19229290
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with DYNC1LI1: view

Pathways for DYNC1LI1 Gene

genes like me logo Genes that share pathways with DYNC1LI1: view

Pathways by source for DYNC1LI1 Gene

Gene Ontology (GO) - Biological Process for DYNC1LI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007018 microtubule-based movement IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008152 metabolic process IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with DYNC1LI1: view

Transcripts for DYNC1LI1 Gene

Unigene Clusters for DYNC1LI1 Gene

Dynein, cytoplasmic 1, light intermediate chain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYNC1LI1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DYNC1LI1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for DYNC1LI1 Gene

GeneLoc Exon Structure for
DYNC1LI1
ECgene alternative splicing isoforms for
DYNC1LI1

Expression for DYNC1LI1 Gene

mRNA expression in normal human tissues for DYNC1LI1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNC1LI1 Gene

SOURCE GeneReport for Unigene cluster for DYNC1LI1 Gene Hs.529495

genes like me logo Genes that share expressions with DYNC1LI1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DYNC1LI1 Gene

Orthologs for DYNC1LI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1LI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNC1LI1 35
  • 99.68 (n)
  • 100 (a)
DYNC1LI1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNC1LI1 35
  • 92.29 (n)
  • 95.03 (a)
DYNC1LI1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNC1LI1 35
  • 94.07 (n)
  • 96.56 (a)
DYNC1LI1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dync1li1 35
  • 86.08 (n)
  • 93.49 (a)
Dync1li1 16
Dync1li1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNC1LI1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1LI1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dync1li1 35
  • 85.89 (n)
  • 93.3 (a)
chicken
(Gallus gallus)
Aves DYNC1LI1 35
  • 81.03 (n)
  • 86.74 (a)
DYNC1LI1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNC1LI1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dnclic1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dync1li1 35
  • 77.27 (n)
  • 81.62 (a)
Str.20512 35
zebrafish
(Danio rerio)
Actinopterygii dync1li1 35
  • 65.89 (n)
  • 69.07 (a)
dync1li1 36
  • 67 (a)
OneToOne
wufc73a07 35
fruit fly
(Drosophila melanogaster)
Insecta Dlic 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dli-1 36
  • 31 (a)
OneToMany
Species with no ortholog for DYNC1LI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1LI1 Gene

ENSEMBL:
Gene Tree for DYNC1LI1 (if available)
TreeFam:
Gene Tree for DYNC1LI1 (if available)

Paralogs for DYNC1LI1 Gene

Paralogs for DYNC1LI1 Gene

Pseudogenes.org Pseudogenes for DYNC1LI1 Gene

genes like me logo Genes that share paralogs with DYNC1LI1: view

Variants for DYNC1LI1 Gene

Sequence variations from dbSNP and Humsavar for DYNC1LI1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs238835 -- 32,561,586(-) agtgg(C/T)gccat intron-variant
rs342722 -- 32,530,848(-) gcctc(A/G)tatgc intron-variant
rs342723 -- 32,529,383(-) ATTGT(A/G)AACCA intron-variant
rs342727 -- 32,551,396(+) CATGA(A/G)ATTTA intron-variant
rs342728 -- 32,555,208(+) AACAT(C/T)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNC1LI1 Gene

Variant ID Type Subtype PubMed ID
nsv834652 CNV Loss 17160897
nsv3752 CNV Loss 18451855

Relevant External Links for DYNC1LI1 Gene

HapMap Linkage Disequilibrium report
DYNC1LI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNC1LI1 Gene

Disorders for DYNC1LI1 Gene

No disorders were found for DYNC1LI1 Gene.

No data available for UniProtKB/Swiss-Prot for DYNC1LI1 Gene

Publications for DYNC1LI1 Gene

  1. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. (PMID: 19229290) Sivaram M.V. … Doxsey S.J. (EMBO J. 2009) 3 4
  2. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PMID: 18247557) Jones J. … Huang L. (J. Proteome Res. 2008) 3

Products for DYNC1LI1 Gene

Sources for DYNC1LI1 Gene

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