Aliases for DYNC1LI1 Gene
External Ids for DYNC1LI1 Gene
Previous HGNC Symbols for DYNC1LI1 Gene
GeneCards Summary for DYNC1LI1 Gene
DYNC1LI1 (Dynein, Cytoplasmic 1, Light Intermediate Chain 1) is a Protein Coding gene. Among its related pathways are Salmonella infection (KEGG) and Vasopressin-regulated water reabsorption. GO annotations related to this gene include poly(A) RNA binding and microtubule motor activity. An important paralog of this gene is DYNC1LI2.
UniProtKB/Swiss-Prot for DYNC1LI1 Gene
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.