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DYNC1LI1 Gene

protein-coding   GIFtS: 57
GCID: GC03M032543

Dynein, Cytoplasmic 1, Light Intermediate Chain 1

(Previous names: dynein, cytoplasmic, light intermediate polypeptide 1)
(Previous symbol: DNCLI1)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynein, Cytoplasmic 1, Light Intermediate Chain 11 2     DLC-A2 3
DNCLI11 2 3     LIC12 3
Dynein, Cytoplasmic, Light Intermediate Polypeptide 11 2     Cytoplasmic Dynein 1 Light Intermediate Chain 12
Dynein Light Chain A2 3     Dynein Light Chain-A2
Dynein Light Intermediate Chain 1, Cytosolic2 3     

External Ids:    HGNC: 187451   Entrez Gene: 511432   Ensembl: ENSG000001446357   UniProtKB: Q9Y6G93   

Export aliases for DYNC1LI1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DYNC1LI1 Gene:
DYNC1LI1 (dynein, cytoplasmic 1, light intermediate chain 1) is a protein-coding gene. Diseases associated with DYNC1LI1 include hiv-1. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1LI2.

UniProtKB/Swiss-Prot: DC1L1_HUMAN, Q9Y6G9
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the
microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint.
The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from
kinetochores

Gene Wiki entry for DYNC1LI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DYNC1LI1 gene promoter:
         Pax-5   SREBP-1c   SREBP-1b   RORalpha2   RORalpha1   POU2F1   SREBP-1a   POU2F1a   HOXA5   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYNC1LI1 promoter sequence
   Search Chromatin IP Primers for DYNC1LI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYNC1LI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p23

DYNC1LI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNC1LI1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M032543:  view genomic region     (about GC identifiers)

Start:
32,567,463 bp from pter      End:
32,612,366 bp from pter
Size:
44,904 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DC1L1_HUMAN, Q9Y6G9 (See protein sequence)
Recommended Name: Cytoplasmic dynein 1 light intermediate chain 1  
Size: 523 amino acids; 56579 Da
Subunit: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs)
and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs)
and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy
chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic
subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates.
Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT (By
similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus
intracellular transport
Secondary accessions: A2RRG7 Q53HC8 Q53HK7

Explore the universe of human proteins at neXtProt for DYNC1LI1: NX_Q9Y6G9

Explore proteomics data for DYNC1LI1 at MOPED

Post-translational modifications: 

  • Phosphorylated during mitosis but not in interphase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DYNC1LI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057225.2  
    ENSEMBL proteins: 
     ENSP00000273130   ENSP00000407279   ENSP00000390507   ENSP00000409019  

    DYNC1LI1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DYN: Cytoplasmic dyneins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR022780 Dynein_light_int_chain
     IPR008467 Dynein1_light_intermed_chain

    Graphical View of Domain Structure for InterPro Entry Q9Y6G9

    ProtoNet protein and cluster: Q9Y6G9

    1 Blocks protein domain: IPB008467 Dynein light intermediate chain

    UniProtKB/Swiss-Prot: DC1L1_HUMAN, Q9Y6G9
    Similarity: Belongs to the dynein light intermediate chain family


    DYNC1LI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DC1L1_HUMAN, Q9Y6G9
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the
    microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint.
    The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from
    kinetochores

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    DYNC1LI1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dync1li1):
     behavior/neurological  cellular  digestive/alimentary  nervous system 

    DYNC1LI1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYNC1LI1
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    miRNA
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    miRTarBase miRNAs that target DYNC1LI1:
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    5 qRT-PCR Assays for microRNAs that regulate DYNC1LI1:
    hsa-miR-3678-3p hsa-miR-582-5p hsa-miR-3920 hsa-miR-3919 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidDYNC1LI1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DYNC1LI1 (NM_016141)
    Sino Biological Human cDNA Clone for DYNC1LI1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DC1L1_HUMAN, Q9Y6G9: Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton,
    spindle pole
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    cytosol3
    endosome2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA19229290
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IDA19229290
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    DYNC1LI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DYNC1LI1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    3Salmonella infection (KEGG)
    Salmonella infection0.30
    4Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    5Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DYNC1LI1
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF



    3 Kegg Pathways  (Kegg details for DYNC1LI1):
        Phagosome
    Vasopressin-regulated water reabsorption
    Salmonella infection


    DYNC1LI1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYNC1LI1
    Interactions:

        Search GeneGlobe Interaction Network for DYNC1LI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DYNC1LI1 (Q9Y6G92, 3 ENSP000002731304) via UniProtKB, MINT, STRING, and/or I2D (see all 623)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNTO956132, 3, ENSP000003525724MINT-7947479 I2D: score=1 STRING: ENSP00000352572
    MAD2L1Q132572, 3, ENSP000002965094MINT-7264691 I2D: score=1 STRING: ENSP00000296509
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    NUP85Q9BW273, ENSP000002455444I2D: score=1 STRING: ENSP00000245544
    RAB4AP203383, ENSP000003556514I2D: score=2 STRING: ENSP00000355651
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0007018microtubule-based movement IEA--
    GO:0007067mitosis IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    DYNC1LI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYNC1LI1 (DC1L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DYNC1LI1 gene: 
    NM_016141.3  

    Unigene Cluster for DYNC1LI1:

    Dynein, cytoplasmic 1, light intermediate chain 1
    Hs.529495  [show with all ESTs]
    Unigene Representative Sequence: NM_016141
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273130(uc003cfb.4 uc011axh.2) ENST00000481915 ENST00000432458
    ENST00000472985 ENST00000413350 ENST00000424991 ENST00000475193 ENST00000474077

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    5 qRT-PCR Assays for microRNAs that regulate DYNC1LI1:
    hsa-miR-3678-3p hsa-miR-582-5p hsa-miR-3920 hsa-miR-3919 hsa-miR-1252
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    Additional mRNA sequence: 

    AF078849.1 AK001081.1 AK074348.1 AK222573.1 AK222653.1 AK293253.1 BC131620.1 

    9 DOTS entries:

    DT.447414  DT.100814567  DT.92437869  DT.99931463  DT.100814580  DT.120867585  DT.120867590  DT.120867595 
    DT.95166642 

    Selected AceView cDNA sequences (see all 245):

    CA434202 BE857001 AU119954 BM453048 CR595277 CD627565 CR623843 CA449447 
    CA446301 CK819195 BM996774 AI682450 F06312 CR619992 AA488150 BM128151 
    CB163306 AL550510 CA438680 AI381316 AK001081 AW518200 AA600137 BM994991 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1LI1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                -     -                 -                                                                     
    SP2:                                -     -     -     -     -                                                                     
    SP3:                                -                                                                                             
    SP4:                                      -                 -                                                                     
    SP5:                                -     -                                                                                       


    ECgene alternative splicing isoforms for DYNC1LI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYNC1LI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAACTAGA
    DYNC1LI1 Expression
    About this image

    DYNC1LI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYNC1LI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529495
        Custom PCR Arrays for DYNC1LI1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNC1LI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DYNC1LI1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dync1li11 , 5 dynein cytoplasmic 1 light intermediate chain 11, 5 86.08(n)1
    93.49(a)1
      9 (64.96 cM)5
    2356611  NM_146229.21  NP_666341.11 
     1146888315 
    chicken
    (Gallus gallus)
    Aves DYNC1LI11 dynein, cytoplasmic 1, light intermediate chain 1 81.03(n)
    86.74(a)
      420668  NM_001167737.1  NP_001161209.1 
    lizard
    (Anolis carolinensis)
    Reptilia DYNC1LI16
    dynein, cytoplasmic 1, light intermediate chain 1
    72(a)
    1 ↔ 1
    1(193476359-193511053)
    African clawed frog
    (Xenopus laevis)
    Amphibia dnclic1-prov2 cytoplasmic dynein light-intermediate chain 80(n)    BC045030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc73a072 Transcribed sequence with weak similarity to protein more 71.1(n)    CA496732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dlic6
    Dynein light intermediate chain
    44(a)
    1 → many
    X(11048434-11057245)
    worm
    (Caenorhabditis elegans)
    Secernentea dli-16
    Protein DLI-1, isoform b (dli-1) mRNA, complete cd...
    31(a)
    1 → many
    IV(13096983-13098813) WBGene00001007


    ENSEMBL Gene Tree for DYNC1LI1 (if available)
    TreeFam Gene Tree for DYNC1LI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYNC1LI1 gene
    DYNC1LI22  
    Selected SIMAP similar genes for DYNC1LI1 using alignment to 4 protein entries:     DC1L1_HUMAN (see all proteins) (see all similar genes):
    FLJ00047    RBP7    COQ5    KIAA1651    DKFZp686A1525    PFKFB3
    DKFZp686J08252    C12orf76    SNRPF    GALK2    TUBA1C    pp12301
    SEC14L3    SH2B3    DYNC1LI2    ERMN    ATF1    LINC00999

    DYNC1LI1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DYNC1LI1
    PGOHUM00000235176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYNC1LI1 (see all 1001)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs738265781,2
    C,F--32567075(+) TCGAAA/CATTTT 1 -- int13Minor allele frequency- C:0.15WA CSA 121
    rs764382851,2
    F--32567161(+) AAAAAG/ATTGCA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs2014912551,2
    --32567206(+) AACAA-/TACAG 
            
    TATAA
    1 -- int10--------
    rs1859662651,2
    --32567208(+) CAATAC/TAGTAT 1 -- int10--------
    rs603231071,2
    C--32567282(+) AGGAGG/AATGTG 1 -- int13Minor allele frequency- A:0.15CSA WA EA 240
    rs1898347211,2
    --32567381(+) CCTCAC/TGGATA 1 -- int10--------
    rs106626661,2
    C--32567554(+) AAGCC-/ATatata 1 -- ut310--------
    rs677584581,2
    C--32567555(+) AAGCC-/ATATATA 1 -- ut310--------
    rs1163639831,2
    C,F--32567571(+) TATATA/GTGTAT 1 -- ut311Minor allele frequency- G:0.07WA 118
    rs608963361,2
    C--32567572(+) TATAT-/AT    
       
    /ATAT
    GTATA
    2 -- ut310--------

    HapMap Linkage Disequilibrium report for DYNC1LI1 (32567463 - 32612366 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYNC1LI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3752CNV Loss18451855
    nsv834652CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYNC1LI1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for DYNC1LI1:    
    About MalaCards
    hiv-1


    DYNC1LI1 for disorders           About GeneDecksing


    Export disorders for DYNC1LI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYNC1LI1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with DYNC1LI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. (PubMed id 19229290)1, 2 Sivaram M.V.... Doxsey S.J. (EMBO J. 2009)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (J. Cell Biol. 2005)
    4. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. (PubMed id 21169557)1 Tan S.C....Vallee R.B. (Mol. Biol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51143 HGNC: 18745 AceView: DNCLI1 Ensembl:ENSG00000144635 euGenes: HUgn51143
    ECgene: DYNC1LI1 Kegg: 51143 H-InvDB: DYNC1LI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYNC1LI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYNC1LI1 gene:
    Search GeneIP for patents involving DYNC1LI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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