Aliases for DYNC1I2 Gene
External Ids for DYNC1I2 Gene
Previous HGNC Symbols for DYNC1I2 Gene
Previous GeneCards Identifiers for DYNC1I2 Gene
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for DYNC1I2 Gene
DYNC1I2 (Dynein Cytoplasmic 1 Intermediate Chain 2) is a Protein Coding gene. Diseases associated with DYNC1I2 include Leukorrhea. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Golgi-to-ER retrograde transport. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1I1.
UniProtKB/Swiss-Prot for DYNC1I2 Gene
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.