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Aliases for DYNC1I2 Gene

Aliases for DYNC1I2 Gene

  • Dynein Cytoplasmic 1 Intermediate Chain 2 2 3 5
  • Dynein, Cytoplasmic, Intermediate Polypeptide 2 2 3
  • Dynein Intermediate Chain 2, Cytosolic 3 4
  • DH IC-2 3 4
  • DNCI2 3 4
  • Testis Tissue Sperm-Binding Protein Li 66n 3
  • Cytoplasmic Dynein 1 Intermediate Chain 2 3
  • Cytoplasmic Dynein Intermediate Chain 2 4
  • DNCIC2 4
  • DIC74 3
  • IC2 3

External Ids for DYNC1I2 Gene

Previous HGNC Symbols for DYNC1I2 Gene

  • DNCI2

Previous GeneCards Identifiers for DYNC1I2 Gene

  • GC02P172370
  • GC02P172252
  • GC02P172543
  • GC02P164429

Summaries for DYNC1I2 Gene

Entrez Gene Summary for DYNC1I2 Gene

  • This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for DYNC1I2 Gene

DYNC1I2 (Dynein Cytoplasmic 1 Intermediate Chain 2) is a Protein Coding gene. Diseases associated with DYNC1I2 include Leukorrhea. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Innate Immune System. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is DYNC1I1.

UniProtKB/Swiss-Prot for DYNC1I2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

Gene Wiki entry for DYNC1I2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1I2 Gene

Genomics for DYNC1I2 Gene

Regulatory Elements for DYNC1I2 Gene

Enhancers for DYNC1I2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G172092 3.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 1.6 +410.8 410772 10.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC DAP3P2 DCAF17 DLX2 HAT1 ENSG00000232788 ITGA6 DLX1 DYNC1I2 GC02P172093
GH02G171686 1.1 ENCODE 0.7 +0.7 698 2.5 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 DCAF17 DAP3P2 RPS15P4 TLK1 HAT1 DYNC1I2 GC02P171811
GH02G171711 1.1 Ensembl ENCODE 0.3 +24.7 24701 2.0 PKNOX1 ARNT INSM2 FEZF1 ZEB1 EGR1 ZNF366 ZSCAN5C FOS PAF1 SLC25A12 METAP1D DYNC1I2 GC02P171811
GH02G171762 0.7 ENCODE 0.2 +75.9 75875 0.9 SOX5 SOX13 NFIA NFIB FOXA3 ZNF7 FOSL1 NFIC GATA3 JUND GC02P171811 DYNC1I2
GH02G171797 1.1 Ensembl ENCODE 0.1 +111.1 111094 1.5 ELF3 FOXA2 RAD21 RARA GATA2 FOS RCOR2 HMBOX1 HNF4A SOX13 RNU6-182P SLC25A12 GC02P171811 DYNC1I2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DYNC1I2 on UCSC Golden Path with GeneCards custom track

Promoters for DYNC1I2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126222 791 2001 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for DYNC1I2 Gene

Chromosome:
2
Start:
171,687,409 bp from pter
End:
171,750,158 bp from pter
Size:
62,750 bases
Orientation:
Plus strand

Genomic View for DYNC1I2 Gene

Genes around DYNC1I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNC1I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNC1I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1I2 Gene

Proteins for DYNC1I2 Gene

  • Protein details for DYNC1I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13409-DC1I2_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 intermediate chain 2
    Protein Accession:
    Q13409
    Secondary Accessions:
    • B7ZA04
    • D3DPD4
    • D3DPD5
    • D3DPD6
    • Q32LY9
    • Q53S84
    • Q5BJF8
    • Q7Z4X1
    • Q96NG7
    • Q96S87
    • Q9BXZ5
    • Q9NT58

    Protein attributes for DYNC1I2 Gene

    Size:
    638 amino acids
    Molecular mass:
    71457 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport (PubMed:20006841). Interacts with BICD2 (By similarity).
    SequenceCaution:
    • Sequence=AAA89166.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DYNC1I2 Gene

    Alternative splice isoforms for DYNC1I2 Gene

neXtProt entry for DYNC1I2 Gene

Post-translational modifications for DYNC1I2 Gene

  • The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DYNC1I2

No data available for DME Specific Peptides for DYNC1I2 Gene

Domains & Families for DYNC1I2 Gene

Gene Families for DYNC1I2 Gene

Protein Domains for DYNC1I2 Gene

Suggested Antigen Peptide Sequences for DYNC1I2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13409

UniProtKB/Swiss-Prot:

DC1I2_HUMAN :
  • Belongs to the dynein intermediate chain family.
Family:
  • Belongs to the dynein intermediate chain family.
genes like me logo Genes that share domains with DYNC1I2: view

Function for DYNC1I2 Gene

Molecular function for DYNC1I2 Gene

UniProtKB/Swiss-Prot Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

Gene Ontology (GO) - Molecular Function for DYNC1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0003777 microtubule motor activity NAS 8522607
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DYNC1I2: view
genes like me logo Genes that share phenotypes with DYNC1I2: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNC1I2 Gene

Localization for DYNC1I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1I2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DYNC1I2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for DYNC1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 8522607
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005868 cytoplasmic dynein complex IEA --
genes like me logo Genes that share ontologies with DYNC1I2: view

Pathways & Interactions for DYNC1I2 Gene

genes like me logo Genes that share pathways with DYNC1I2: view

Gene Ontology (GO) - Biological Process for DYNC1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007018 microtubule-based movement IEA,NAS 8522607
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with DYNC1I2: view

No data available for SIGNOR curated interactions for DYNC1I2 Gene

Drugs & Compounds for DYNC1I2 Gene

No Compound Related Data Available

Transcripts for DYNC1I2 Gene

Unigene Clusters for DYNC1I2 Gene

Dynein, cytoplasmic 1, intermediate chain 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1I2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for DYNC1I2 Gene

GeneLoc Exon Structure for
DYNC1I2
ECgene alternative splicing isoforms for
DYNC1I2

Expression for DYNC1I2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DYNC1I2 Gene

Protein differential expression in normal tissues from HIPED for DYNC1I2 Gene

This gene is overexpressed in Fetal Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DYNC1I2 Gene



Protein tissue co-expression partners for DYNC1I2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DYNC1I2 Gene:

DYNC1I2

SOURCE GeneReport for Unigene cluster for DYNC1I2 Gene:

Hs.546250

Evidence on tissue expression from TISSUES for DYNC1I2 Gene

  • Nervous system(5)
  • Kidney(4.6)
  • Liver(4.6)
  • Skin(4.5)
  • Intestine(2.5)
  • Spleen(2.4)
  • Lung(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with DYNC1I2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DYNC1I2 Gene

Orthologs for DYNC1I2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1I2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DYNC1I2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYNC1I2 34 35
  • 99.89 (n)
mouse
(Mus musculus)
Mammalia Dync1i2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1I2 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNC1I2 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNC1I2 34 35
  • 94.28 (n)
chicken
(Gallus gallus)
Aves DYNC1I2 34 35
  • 83.96 (n)
lizard
(Anolis carolinensis)
Reptilia DYNC1I2 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.139 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.775 34
zebrafish
(Danio rerio)
Actinopterygii DYNC1I2 (3 of 3) 35
  • 84 (a)
OneToMany
dync1i2b 35
  • 83 (a)
OneToMany
dync1i2a 35
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sdic4 35
  • 54 (a)
ManyToMany
Sdic2 35
  • 54 (a)
ManyToMany
Sdic3 35
  • 52 (a)
ManyToMany
Sdic1 35
  • 49 (a)
ManyToMany
sw 35
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dyci-1 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.507 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2485 34
Species where no ortholog for DYNC1I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1I2 Gene

ENSEMBL:
Gene Tree for DYNC1I2 (if available)
TreeFam:
Gene Tree for DYNC1I2 (if available)

Paralogs for DYNC1I2 Gene

Paralogs for DYNC1I2 Gene

Pseudogenes.org Pseudogenes for DYNC1I2 Gene

genes like me logo Genes that share paralogs with DYNC1I2: view

Variants for DYNC1I2 Gene

Sequence variations from dbSNP and Humsavar for DYNC1I2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000068600 -- 171,750,274(+) ATAAT(A/G)CTGAA downstream-variant-500B
rs1000110289 -- 171,726,713(+) ATCTG(A/T)TAAAG intron-variant
rs1000143660 -- 171,708,810(+) ACATC(A/T)GCCTC intron-variant
rs1000145404 -- 171,697,192(+) TTTTG(-/T)TTTTT intron-variant
rs1000184250 -- 171,745,979(+) TTGTA(A/G)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNC1I2 Gene

Variant ID Type Subtype PubMed ID
esv3306812 CNV mobile element insertion 20981092
esv3353811 CNV insertion 20981092
nsv511089 OTHER complex 20534489
nsv522519 CNV loss 19592680
nsv834457 CNV loss 17160897

Variation tolerance for DYNC1I2 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNC1I2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DYNC1I2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNC1I2 Gene

Disorders for DYNC1I2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYNC1I2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukorrhea
  • discharge - leukorrhea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DYNC1I2

Genetic Association Database (GAD)
DYNC1I2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNC1I2
genes like me logo Genes that share disorders with DYNC1I2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYNC1I2 Gene

Publications for DYNC1I2 Gene

  1. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. (PMID: 10049579) Crackower M.A. … Tsui L.-C. (Genomics 1999) 2 3 22 64
  2. Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis. (PMID: 19744529) Pyr dit Ruys S. … Michiels C. (Biochim. Biophys. Acta 2009) 3 22 64
  3. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DYNC1I2 Gene

Sources for DYNC1I2 Gene

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