DYNC1I2 Gene
protein-coding GIFtS: 60
GCID: GC02P172543
|
|
dynein, cytoplasmic 1, intermediate chain 2(Previous names: dynein, cytoplasmic, intermediate polypeptide 2 )
(Previous symbol: DNCI2)
| |
Aliases
for DYNC1I2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dynein, Cytoplasmic 1, Intermediate Chain 21 2 | | IC22 5 | | DNCI21 2 3 5 | | Cytoplasmic Dynein 1 Intermediate Chain 22 | | Dynein, Cytoplasmic, Intermediate Polypeptide 21 2 | | DNCIC23 | | Dynein Intermediate Chain 2, Cytosolic2 3 | | Cytoplasmic Dynein Intermediate Chain 23 | | DH IC-22 3 | | |
Export aliases for DYNC1I2 gene to outside databasesPrevious GC identifers: GC02P172370 GC02P172252 GC02P164429 |
Summaries
for DYNC1I2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DYNC1I2:
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component ofthe cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. Apseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: DC1I2_HUMAN, Q13409Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Theintermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involvedin membrane-transport, such as Golgi apparatus, late endosomes and lysosomes
Gene Wiki entry for DYNC1I2
|
Genomic Views
for DYNC1I2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYNC1I2 gene promoter:
AML1a C/EBPalpha Evi-1 AREB6 MEF-2A POU2F1 POU2F1a Sox9 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYNC1I2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNC1I2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1DYNC1I2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P172543: view genomic region
(about GC identifiers)
Start:
|
172,543,919 bp from pter |
End:
|
172,604,930 bp from pter |
Size:
|
61,012 bases |
Orientation:
|
plus strand |
|
Proteins
for DYNC1I2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DC1I2_HUMAN, Q13409 (See
protein sequence)Recommended Name: Cytoplasmic dynein 1 intermediate chain 2 Size: 638 amino acids; 71457 Da
Subunit: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and anumber of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and lightchains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimerserves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICsbind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts withDCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virusintracellular transport
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=AAA89166.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequenceproblems;
Secondary accessions: D3DPD4 D3DPD5 D3DPD6 Q32LY9 Q53S84 Q5BJF8 Q7Z4X1 Q96NG7 Q96S87 Q9BXZ5 Q9NT58Alternative splicing: 5 isoforms: Q13409-1 Q13409-2 Q13409-3 Q13409-5 Q13409-6 (Contains a phosphoserine at position 73. Contains a phosphoserine at position 81)Explore the universe of human proteins at neXtProt for DYNC1I2: NX_Q13409
Post-translational modifications:
The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13409
DYNC1I2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001258714.1 NP_001258715.1 NP_001258716.1 NP_001258717.1 NP_001258718.1 NP_001258719.1 NP_001369.1
ENSEMBL proteins: ENSP00000398765 ENSP00000339430 ENSP00000380308 ENSP00000386522 ENSP00000392741 ENSP00000423339 ENSP00000386397 ENSP00000388699 ENSP00000386591 ENSP00000386415 ENSP00000405454 ENSP00000386886 ENSP00000415410 ENSP00000410807 ENSP00000401005 ENSP00000406104 ENSP00000397654 ENSP00000394492 ENSP00000409951 ENSP00000403089 ENSP00000433791 ENSP00000263811 ENSP00000350692 Reactome Protein details: Q13409
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
DYNC1I2 for ontologies About GeneDecksing
DYNC1I2 Antibody Products:
Assay Products for DYNC1I2: |
Protein
Domains /
Families
for DYNC1I2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYNC1I2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13409ProtoNet protein and cluster: Q13409 UniProtKB/Swiss-Prot: DC1I2_HUMAN, Q13409Similarity: Belongs to the dynein intermediate chain familySimilarity: Contains 7 WD repeats |
Function
for DYNC1I2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DC1I2_HUMAN, Q13409Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that arethought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmicdynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Theintermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involvedin membrane-transport, such as Golgi apparatus, late endosomes and lysosomes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNC1I2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNC1I2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DYNC1I2 (NM_001378) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYNC1I2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNC1I2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNC1I2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003777 | microtubule motor activity |
NAS | 8522607 |
DYNC1I2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DYNC1I2:
Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dync1i2):
DYNC1I2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DYNC1I2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Immune System | | | 4 | Cell Cycle | | | 5 | MHC class II antigen presentation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DYNC1I2
2  GeneGo (Thomson Reuters) Pathways for DYNC1I2
5/12 
Reactome Pathways for DYNC1I2 (see all 12)
2 
Kegg Pathways (Kegg details for DYNC1I2):
DYNC1I2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNC1I2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/116 Interacting proteins for DYNC1I2 (Q134092, 3 ENSP000003803084) via UniProtKB, MINT, STRING, and/or I2D (see all 116)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
DYNC1I2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DYNC1I2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DYNC1I2
Search CenterWatch for drugs/clinical trials and news about DYNC1I2 / DC1I2
|
Transcripts
for DYNC1I2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DYNC1I2 gene (7 alternative transcripts): NM_001271785.1 NM_001271786.1 NM_001271787.1 NM_001271788.1 NM_001271789.1 NM_001271790.1 NM_001378.2 Unigene Cluster for DYNC1I2: Dynein, cytoplasmic 1, intermediate chain 2 Hs.632981 [show with all ESTs]Unigene Representative Sequence: NM_00137818/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28): ENST00000452242 ENST00000340296(uc002uhb.1 uc002uhc.3) ENST00000397119(uc002uha.1)
ENST00000410079 ENST00000471482 ENST00000438879 ENST00000508530 ENST00000409197(uc002uhf.1 uc010zdt.1)
ENST00000456808 ENST00000409317(uc002uhd.1) ENST00000409773(uc002uhe.1)
ENST00000411953 ENST00000409453 ENST00000445378 ENST00000435234 ENST00000443458
ENST00000412370 ENST00000423910
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNC1I2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNC1I2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DYNC1I2 (NM_001378) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYNC1I2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNC1I2 |
Additional cDNA sequence: AB209014.1 AF134477.1 AF250307.1 AK024742.1 AK026574.1 AK055491.1 AK096579.1 AK225759.1 AK298561.1 AK301866.1 AK308008.1 AK316119.1 AL137519.1 AL832832.1 AY037160.1 BC015038.2 BC091498.1 BC109375.1 BT007130.1 BX537412.1 DQ786313.1 DQ786324.1 U39575.1 24/34 DOTS entries (see all 34): DT.100846178 DT.418547 DT.91998165 DT.100670130 DT.120949068 DT.100846179 DT.100846181 DT.97851322 DT.100762482 DT.99995683 DT.100846182 DT.92057415 DT.100668415 DT.100846189 DT.40284256 DT.408071 DT.120949149 DT.95165877 DT.120949082 DT.120949157 DT.95165875 DT.100846183 DT.100846188 DT.120949072 24/409 AceView cDNA sequences (see all 409): D58196 F31817 BM462394 N29856 AA235213 BM975244 AL551174 BX421615 BX646838 BP357591 BQ671460 AI367340 BM452006 AI381288 BX464948 BQ776321 AA195151 BU729668 BX117871 AW002687 BC015038 BQ722194 BM677354 BQ721938
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1I2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DYNC1I2
|
Expression
for DYNC1I2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DYNC1I2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTAGTTAC
About this image
See DYNC1I2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYNC1I2
SOURCE GeneReport for Unigene cluster: Hs.632981
SABiosciences Custom PCR Arrays for DYNC1I2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYNC1I2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYNC1I2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNC1I2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNC1I2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNC1I2 |
Orthologs
for DYNC1I2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DYNC1I2 gene from 6/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DYNC1I21 |
dynein, cytoplasmic 1, intermediate chain 2 |
84.18(n)
95.57(a) |
|
424151 NM_001006519.1 NP_001006519.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DYNC1I26 |
-- |
93(a) |
1 ↔ 1 |
GL343353.1(722436-766496) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.7752 |
Xenopus laevis clone 2 cytoplasmic dynein intermediate more |
81.63(n) |
|
AF319781.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570827562 |
-- |
72.78(n) |
|
57082756 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sw1 |
short wing |
53.2(n)
53.87(a) |
|
44160 NM_057727.4 NP_477075.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
dyci-11 |
Protein DYCI-1 |
49.39(n)
39.9(a) |
|
177440 NM_068637.2 NP_501038.1 |
ENSEMBL Gene Tree for DYNC1I2 (if available)
TreeFam Gene Tree for DYNC1I2 (if available) |
Paralogs
for DYNC1I2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DYNC1I2 gene
- WDR632 DNAI22 DYNC1I12 WDR342 DNAI12 WDR782
3 SIMAP similar genes for DYNC1I2 using alignment to 15 protein entries: DC1I2_HUMAN (see all proteins):DNCI2 DNCI1 DYNC1I1
DYNC1I2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DYNC1I2
PGOHUM00000238794
|
Genomic Variants
for DYNC1I2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DYNC1I2 (172543919 - 172604930 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DYNC1I2
1 Indel: 40388 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNC1I2 |
|
Disorders
/ Diseases
for DYNC1I2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYNC1I2 for disorders About GeneDecksing
OMIM gene information: 603331
OMIM disorders: --
5  diseases for DYNC1I2: About MalaCardsbeckwith-wiedemann syndrome leukorrhea cardia cancer hypoxia
malaria
2 diseases from the University of Copenhagen DISEASES database for DYNC1I2:Beckwith-Wiedemann syndrome Leukorrhea 1 Novoseek disease relationship for DYNC1I2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
19744529 (1) |
Export disorders for DYNC1I2 gene to outside databases
|
Publications
for DYNC1I2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DYNC1I2 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with DYNC1I2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. (PubMed id 10049579)1, 3, 9 Crackower M.A.... Tsui L.-C. (1999)
- Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. (PubMed id 8522607)1, 2 Vaughan K.T. and Vallee R.B. (1995)
- Identification of DH IC-2 as a HIF-1 independent prot ein involved in the adaptive response to hypoxia in tumor cells: A putative rol e in metastasis. (PubMed id 19744529)1, 9 Pyr dit Ruys S....Michiels C. (2009)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport. (PubMed id 22094641)1 Morel M....Brion J.P. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
|
External Searches for DYNC1I2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYNC1I2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYNC1I2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYNC1I2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DYNC1I2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DYNC1I2 gene:
Search GeneIP for patents involving DYNC1I2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYNC1I2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DYNC1I2 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DYNC1I2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYNC1I2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DYNC1I2 | | OriGene 3'-UTR Clone for DYNC1I2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYNC1I2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYNC1I2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DYNC1I2 | | OriGene Custom Protein Services for DYNC1I2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DYNC1I2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNC1I2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNC1I2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DYNC1I2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYNC1I2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYNC1I2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DYNC1I2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DYNC1I2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYNC1I2 |
|  |  |  | | | | ThermoFisher Antibodies for DYNC1I2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYNC1I2 |
|
|
|
|
