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Aliases for DYNC1I2 Gene

Aliases for DYNC1I2 Gene

  • Dynein, Cytoplasmic 1, Intermediate Chain 2 2 3
  • DNCI2 3 4 6
  • Dynein, Cytoplasmic, Intermediate Polypeptide 2 2 3
  • Dynein Intermediate Chain 2, Cytosolic 3 4
  • DH IC-2 3 4
  • IC2 3 6
  • Cytoplasmic Dynein 1 Intermediate Chain 2 3
  • Cytoplasmic Dynein Intermediate Chain 2 4
  • DNCIC2 4

External Ids for DYNC1I2 Gene

Previous HGNC Symbols for DYNC1I2 Gene

  • DNCI2

Previous GeneCards Identifiers for DYNC1I2 Gene

  • GC02P172370
  • GC02P172252
  • GC02P172543
  • GC02P164429

Summaries for DYNC1I2 Gene

Entrez Gene Summary for DYNC1I2 Gene

  • This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for DYNC1I2 Gene

DYNC1I2 (Dynein, Cytoplasmic 1, Intermediate Chain 2) is a Protein Coding gene. Diseases associated with DYNC1I2 include leukorrhea. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is WDR78.

UniProtKB/Swiss-Prot for DYNC1I2 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes

Gene Wiki entry for DYNC1I2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1I2 Gene

Genomics for DYNC1I2 Gene

Regulatory Elements for DYNC1I2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DYNC1I2 Gene

Start:
171,687,409 bp from pter
End:
171,750,158 bp from pter
Size:
62,750 bases
Orientation:
Plus strand

Genomic View for DYNC1I2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNC1I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1I2 Gene

Proteins for DYNC1I2 Gene

  • Protein details for DYNC1I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13409-DC1I2_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 intermediate chain 2
    Protein Accession:
    Q13409
    Secondary Accessions:
    • B7ZA04
    • D3DPD4
    • D3DPD5
    • D3DPD6
    • Q32LY9
    • Q53S84
    • Q5BJF8
    • Q7Z4X1
    • Q96NG7
    • Q96S87
    • Q9BXZ5
    • Q9NT58

    Protein attributes for DYNC1I2 Gene

    Size:
    638 amino acids
    Molecular mass:
    71457 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.
    SequenceCaution:
    • Sequence=AAA89166.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Several sequence problems.; Evidence={ECO:0000305};

    Alternative splice isoforms for DYNC1I2 Gene

neXtProt entry for DYNC1I2 Gene

Proteomics data for DYNC1I2 Gene at MOPED

Post-translational modifications for DYNC1I2 Gene

  • The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DYNC1I2 Gene

Domains for DYNC1I2 Gene

Gene Families for DYNC1I2 Gene

HGNC:
  • DYN :Cytoplasmic dyneins
  • WDR :WD repeat domain containing

Protein Domains for DYNC1I2 Gene

Suggested Antigen Peptide Sequences for DYNC1I2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13409

UniProtKB/Swiss-Prot:

DC1I2_HUMAN :
  • Q13409
Family:
  • Belongs to the dynein intermediate chain family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DYNC1I2: view

Function for DYNC1I2 Gene

Molecular function for DYNC1I2 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes

Gene Ontology (GO) - Molecular Function for DYNC1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity NAS 8522607
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DYNC1I2: view
genes like me logo Genes that share phenotypes with DYNC1I2: view

miRNA for DYNC1I2 Gene

miRTarBase miRNAs that target DYNC1I2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNC1I2 Gene

Localization for DYNC1I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1I2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNC1I2 Gene COMPARTMENTS Subcellular localization image for DYNC1I2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for DYNC1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 8522607
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005868 cytoplasmic dynein complex IEA --
GO:0005874 microtubule IDA 21525035
genes like me logo Genes that share ontologies with DYNC1I2: view

Pathways for DYNC1I2 Gene

genes like me logo Genes that share pathways with DYNC1I2: view

Gene Ontology (GO) - Biological Process for DYNC1I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006810 transport IEA --
GO:0006996 organelle organization TAS --
GO:0007018 microtubule-based movement NAS 8522607
genes like me logo Genes that share ontologies with DYNC1I2: view

Transcripts for DYNC1I2 Gene

Unigene Clusters for DYNC1I2 Gene

Dynein, cytoplasmic 1, intermediate chain 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYNC1I2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DYNC1I2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1I2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for DYNC1I2 Gene

GeneLoc Exon Structure for
DYNC1I2
ECgene alternative splicing isoforms for
DYNC1I2

Expression for DYNC1I2 Gene

mRNA expression in normal human tissues for DYNC1I2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DYNC1I2 Gene

SOURCE GeneReport for Unigene cluster for DYNC1I2 Gene Hs.546250

genes like me logo Genes that share expressions with DYNC1I2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DYNC1I2 Gene

Orthologs for DYNC1I2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1I2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNC1I2 35
  • 99.89 (n)
  • 100 (a)
DYNC1I2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNC1I2 35
  • 94.28 (n)
  • 98.37 (a)
DYNC1I2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNC1I2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dync1i2 16
Dync1i2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNC1I2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1I2 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves DYNC1I2 35
  • 83.96 (n)
  • 95.07 (a)
DYNC1I2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNC1I2 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.775 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.139 35
zebrafish
(Danio rerio)
Actinopterygii DYNC1I2 (3 of 3) 36
  • 84 (a)
OneToMany
dync1i2a 36
  • 74 (a)
OneToMany
dync1i2b 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sdic1 36
  • 49 (a)
ManyToMany
Sdic2 36
  • 54 (a)
ManyToMany
Sdic3 36
  • 52 (a)
ManyToMany
Sdic4 36
  • 54 (a)
ManyToMany
sw 36
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dyci-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2485 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.507 36
  • 49 (a)
OneToMany
Species with no ortholog for DYNC1I2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1I2 Gene

ENSEMBL:
Gene Tree for DYNC1I2 (if available)
TreeFam:
Gene Tree for DYNC1I2 (if available)

Paralogs for DYNC1I2 Gene

Paralogs for DYNC1I2 Gene

Pseudogenes.org Pseudogenes for DYNC1I2 Gene

genes like me logo Genes that share paralogs with DYNC1I2: view

Variants for DYNC1I2 Gene

Sequence variations from dbSNP and Humsavar for DYNC1I2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs312915 -- 171,717,304(-) AACCC(C/T)ATCTC intron-variant
rs312916 -- 171,716,831(-) cctcc(C/T)gggtt intron-variant
rs312917 -- 171,714,648(-) GTTTA(A/G)AAATA intron-variant
rs312918 -- 171,713,077(-) TCCTA(C/G)AAAAC intron-variant
rs312919 -- 171,711,203(-) caacg(C/T)gatga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNC1I2 Gene

Variant ID Type Subtype PubMed ID
nsv511089 CNV Complex 20534489
nsv834457 CNV Loss 17160897
esv271088 CNV Insertion 20981092
nsv522519 CNV Loss 19592680

Relevant External Links for DYNC1I2 Gene

HapMap Linkage Disequilibrium report
DYNC1I2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNC1I2 Gene

Disorders for DYNC1I2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DYNC1I2 Gene including...

Search for DYNC1I2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DYNC1I2 Gene

(1) Novoseek inferred disease relationships for DYNC1I2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for DYNC1I2

Genetic Association Database (GAD)
DYNC1I2
genes like me logo Genes that share disorders with DYNC1I2: view

No data available for UniProtKB/Swiss-Prot for DYNC1I2 Gene

Publications for DYNC1I2 Gene

  1. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. (PMID: 10049579) Crackower M.A. … Tsui L.-C. (Genomics 1999) 2 3 23
  2. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. (PMID: 8522607) Vaughan K.T. … Vallee R.B. (J. Cell Biol. 1995) 3 4
  3. Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis. (PMID: 19744529) Pyr dit Ruys S. … Michiels C. (Biochim. Biophys. Acta 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DYNC1I2 Gene

Sources for DYNC1I2 Gene

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