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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYNC1I1 Gene

protein-coding   GIFtS: 57
GCID: GC07P095401

dynein, cytoplasmic 1, intermediate chain 1

(Previous names: dynein, cytoplasmic, intermediate polypeptide 1 )
(Previous symbol: DNCI1)
 Explore 3 diseases affiliated with
DYNC1I1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DYNC1I1    

Aliases
for DYNC1I1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dynein, Cytoplasmic 1, Intermediate Chain 11 2     Cytoplasmic Dynein Intermediate Chain 12 3
DNCI11 2 3 5     Dynein Intermediate Chain 1, Cytosolic2 3
DNCIC11 2 3     DH IC-12 3
Dynein, Cytoplasmic, Intermediate Polypeptide 11 2     Cytoplasmic Dynein 1 Intermediate Chain 12

External Ids:    HGNC: 29631   Entrez Gene: 17802   Ensembl: ENSG000001585607   OMIM: 6037725   UniProtKB: O145763   

Export aliases for DYNC1I1 gene to outside databases

Previous GC identifers: GC07P095047 GC07P095239 GC07P090008


Summaries
for DYNC1I1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic
dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The
intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a
role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores

Gene Wiki entry for DYNC1I1


Genomic Views
for DYNC1I1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYNC1I1 gene promoter:
         Brachyury   Pax-2   FOXO3   Pax-2a   IRF-1   Egr-4   FOXO3b   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DYNC1I1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYNC1I1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNC1I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3-q22.1

DYNC1I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNC1I1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P095401:  view genomic region     (about GC identifiers)

Start:
 95,401,818 bp from pter      End:
 95,739,634 bp from pter
Size:
 337,817 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 94,730,870-95,056,794     

Proteins
for DYNC1I1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576 (See protein sequence)
Recommended Name: Cytoplasmic dynein 1 intermediate chain 1  
Size: 645 amino acids; 72955 Da
Subunit: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a
number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light
chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer
serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs
bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and
DYNLT3. Interacts with DCNT1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle
pole
Secondary accessions: Q9Y2X1
Alternative splicing: 3 isoforms:  O14576-1   O14576-2   O14576-3   

Explore the universe of human proteins at neXtProt for DYNC1I1: NX_O14576

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14576

    • DYNC1I1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129028.1  NP_001129029.1  NP_004402.1  

    ENSEMBL proteins: 
     ENSP00000392337   ENSP00000428934   ENSP00000320130   ENSP00000398118   ENSP00000352348  
     ENSP00000411957   ENSP00000428273   ENSP00000412444   ENSP00000438377  
    Reactome Protein details: O14576
    Human Recombinant Protein Products: 
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    Novus Biologicals DYNC1I1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DYNC1I1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA19229290
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IDA19229290
    GO:0005829cytosol TAS--
    GO:0005868cytoplasmic dynein complex ISS--


    DYNC1I1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DYNC1I1

    Protein Domains /
    Families
    for DYNC1I1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DYNC1I1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001680 WD40_repeat
     IPR025956 Dynein_IC_1/2
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O14576

    ProtoNet protein and cluster: O14576

    UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576
    Similarity: Belongs to the dynein intermediate chain family
    Similarity: Contains 7 WD repeats


    Function
    for DYNC1I1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic
    dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The
    intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a
    role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores

    miRNA
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    hsa-miR-3671 hsa-miR-607 hsa-miR-328 hsa-miR-3914 hsa-miR-1291 hsa-miR-1244 hsa-miR-155 hsa-miR-3126-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DYNC1I1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS10049579
    GO:0003777microtubule motor activity ISS--
    GO:0005515protein binding IPI14985359
    GO:0008017microtubule binding ISS--


    DYNC1I1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DYNC1I1:
     Decreased Hepatitis C virus re  Decreased influenza A virus in 


    Pathways & Interactions
    for DYNC1I1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3MHC class II antigen presentation
    		MHC class II antigen presentation1.00
    		Transport of antigen loaded MHC II molecules to surface0.59
    4Vasopressin-regulated water reabsorption
    		Vasopressin-regulated water reabsorption1.00
    5Phagosome
    		Phagosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for DYNC1I1
        Cell cycle Spindle assembly and chromosome separation
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DYNC1I1
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF

    4        Reactome Pathways for DYNC1I1
        Transport of antigen loaded MHC II molecules to surface
    Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    2         Kegg Pathways  (Kegg details for DYNC1I1):
        Phagosome
    Vasopressin-regulated water reabsorption


    DYNC1I1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNC1I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for DYNC1I1 (O145762, 3 ENSP000003201304) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN1Q142032, 3, ENSP000003547914MINT-7899583 MINT-4049943 MINT-7899565 MINT-8254844 I2D: score=2 STRING: ENSP00000354791
    SMN1Q166372, 3MINT-8271080 I2D: score=2 
    SMN2Q166372, 3MINT-8271080 I2D: score=2 
    GSK3BP498412, 3, ENSP000003248064MINT-4049943 I2D: score=1 STRING: ENSP00000324806
    TP53P046372, 3, ENSP000002693054MINT-1891331 I2D: score=1 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--
    GO:0047496vesicle transport along microtubule ISS--


    DYNC1I1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DYNC1I1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DYNC1I1
    Search CenterWatch for drugs/clinical trials and news about DYNC1I1 / DC1I1 

    Transcripts
    for DYNC1I1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DYNC1I1 gene (3 alternative transcripts): 
    NM_001135556.1  NM_001135557.1  NM_004411.4  

    Unigene Cluster for DYNC1I1:

    Dynein, cytoplasmic 1, intermediate chain 1
    Hs.440364  [show with all ESTs]
    Unigene Representative Sequence: NM_004411
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447467(uc003uod.4 uc003uob.3 uc010lfl.3) ENST00000524053
    ENST00000324972(uc003uoc.4) ENST00000437599(uc003uoe.4) ENST00000359388
    ENST00000413338 ENST00000518089 ENST00000457059 ENST00000519371 ENST00000497626
    ENST00000537881

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DYNC1I1:
    hsa-miR-3671 hsa-miR-607 hsa-miR-328 hsa-miR-3914 hsa-miR-1291 hsa-miR-1244 hsa-miR-155 hsa-miR-3126-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DYNC1I1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DYNC1I1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF063228.1 AF123074.1 AK091339.1 AK297427.1 AK309419.1 AK313148.1 BC012504.1 BC022540.1 
    BC032945.2 BC037854.1 BC053542.1 

    13 DOTS entries:

    DT.95366249  DT.100022912  DT.311446  DT.100780212  DT.40121523  DT.95105413  DT.95366303  DT.100780213 
    DT.121066010  DT.121066044  DT.121066067  DT.121066097  DT.99992389 

    24/111 AceView cDNA sequences (see all 111):

    H96244 AK091339 AI702010 AI917122 AI810807 AW160882 AI817595 AA370850 
    CD676444 CD676815 CB155827 AL119852 AW512007 BE671718 BM013807 BU733433 
    Z40531 BQ003509 AW498813 F01454 F03883 AI923516 BM715981 AI631131 

    GeneLoc Exon Structure


    Expression
    for DYNC1I1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYNC1I1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATCTTTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DYNC1I1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneZeugopod Long BoneBone
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    BrainMidbrain tegmentumBrain
    LimbAutopodLimb
    LimbZeugopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See DYNC1I1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYNC1I1

    SOURCE GeneReport for Unigene cluster: Hs.440364
        SABiosciences Custom PCR Arrays for DYNC1I1
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    In Situ
    Assay Products:     
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    Orthologs
    for DYNC1I1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DYNC1I1 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DYNC1I11 dynein, cytoplasmic 1, intermediate chain 1 84.08(n)
    95.81(a)    		   420571  XM_418672.3  XP_418672.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DYNC1I16
    		 --
    		 95(a)
    		 1 ↔ 1
    		 6(22638067-22829964)
    zebrafish
    (Danio rerio)    		 Actinopterygii dync1i11 dynein, cytoplasmic 1, intermediate chain 1 74.22(n)
    79.43(a)    		   561525  NM_001079990.1  NP_001073459.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sdic46
    Sdic26
    (see all 5)    		 Sperm-specific dynein intermediate chain 2
    (see all 5)    		 51(a)
    51(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 X(20091160-20096107)
    X(20076060-20080509)
    worm
    (Caenorhabditis elegans)    		 Secernentea dyci-16
    		 DYnein Chain, light Intermediate family member (dy...
    		 34(a)
    		 1 → many
    		 IV(6779851-6784331)


    ENSEMBL Gene Tree for DYNC1I1 (if available)
    TreeFam Gene Tree for DYNC1I1 (if available) 

    Paralogs
    for DYNC1I1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYNC1I1 gene
    WDR632  DNAI22  WDR342  DNAI12  DYNC1I22  WDR782  
    3 SIMAP similar genes for DYNC1I1 using alignment to 10 protein entries:     DC1I1_HUMAN (see all proteins):
    DNCI1    DNCI2    DYNC1I2

    DYNC1I1 for paralogs           About GeneDecksing



    Genomic Variants
    for DYNC1I1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5262 NCBI SNPs in DYNC1I1 are shown (see all 5262)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1409511901,2
    		--95399883(+) ACACTC/GGTGAG 3 -- us2k10--------
    rs1911849061,2
    		--95399912(+) GCCTCC/TGCCCC 3 -- us2k10--------
    rs1833577601,2
    		--95399975(+) TACTTC/TGTGGG 3 -- us2k10--------
    rs1157004591,2
    		--95399976(+) ACTTCG/ATGGGC 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1467278951,2
    		--95400140(+) TTAGCC/TGGGCT 3 -- us2k10--------
    rs1403693471,2
    		--95400173(+) TAGCTA/GCTCAG 3 -- us2k10--------
    rs77960391,2
    		C,F,--95400211(+) CCCAGG/CAGATG 3 -- us2k16Minor allele frequency- C:0.50NA CSA 12
    rs1876081901,2
    		--95400259(+) AGCCTA/GGGCAT 3 -- us2k10--------
    rs1930754591,2
    		--95400260(+) GCCTGC/GGCATC 3 -- us2k10--------
    rs1488515551,2
    		C,--95400287(+) TCAAA-/AAAC  
                AAACA     		3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DYNC1I1 (95401818 - 95651818 bp, first 250kb of DYNC1I1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DYNC1I1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYNC1I1
    DNA2.0 Custom Variant and Variant Library Synthesis for DYNC1I1

    Disorders / Diseases
    for DYNC1I1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DYNC1I1 for disorders           About GeneDecksing

    OMIM gene information: 603772    OMIM disorders: --

    3 diseases for DYNC1I1:    About MalaCards
    hepatocellular carcinoma    carcinoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: DYNC1I1 (2 documents)

    Export disorders for DYNC1I1 gene to outside databases

    Publications
    for DYNC1I1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYNC1I1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with DYNC1I1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. (PubMed id 10049579)1, 2, 3 Crackower M.A.... Tsui L.-C. (1999)
    2. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. (PubMed id 19229290)1, 2 Sivaram M.V....Doxsey S.J. (2009)
    3. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    7. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Interaction between LIS1 and PDE4, and its role in cy toplasmic dynein function. (PubMed id 21652625)1 Murdoch H....Houslay M.D. (2011)
    10. Digital karyotyping reveals probable target genes at 7q21.3 locus in hepatocellular carcinoma. (PubMed id 21767414)1 Dong H....Jin W. (2011)

    External Searches for DYNC1I1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DYNC1I1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1780 HGNC: 2963 AceView: DNCI1 Ensembl:ENSG00000158560 euGenes: HUgn1780
    ECgene: DYNC1I1 Kegg: 1780 H-InvDB: DYNC1I1

    Other Databases showing DYNC1I1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DYNC1I1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYNC1I1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DYNC1I1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DYNC1I1 gene:
    Search GeneIP for patents involving DYNC1I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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