Aliases for DYNC1I1 Gene
External Ids for DYNC1I1 Gene
Previous HGNC Symbols for DYNC1I1 Gene
Previous GeneCards Identifiers for DYNC1I1 Gene
GeneCards Summary for DYNC1I1 Gene
DYNC1I1 (Dynein Cytoplasmic 1 Intermediate Chain 1) is a Protein Coding gene. Diseases associated with DYNC1I1 include Paranoid Personality Disorder and Split Foot. Among its related pathways are Innate Immune System and Salmonella infection (KEGG). GO annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is DYNC1I2.
UniProtKB/Swiss-Prot for DYNC1I1 Gene
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.