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Aliases for DYNC1I1 Gene

Aliases for DYNC1I1 Gene

  • Dynein, Cytoplasmic 1, Intermediate Chain 1 2 3
  • DNCI1 3 4 6
  • Dynein, Cytoplasmic, Intermediate Polypeptide 1 2 3
  • Cytoplasmic Dynein Intermediate Chain 1 3 4
  • Dynein Intermediate Chain 1, Cytosolic 3 4
  • DH IC-1 3 4
  • DNCIC1 3 4
  • Cytoplasmic Dynein 1 Intermediate Chain 1 3

External Ids for DYNC1I1 Gene

Previous HGNC Symbols for DYNC1I1 Gene

  • DNCI1

Previous GeneCards Identifiers for DYNC1I1 Gene

  • GC07P095047
  • GC07P095239
  • GC07P095401
  • GC07P090008

Summaries for DYNC1I1 Gene

GeneCards Summary for DYNC1I1 Gene

DYNC1I1 (Dynein, Cytoplasmic 1, Intermediate Chain 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Salmonella infection (KEGG). GO annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is WDR78.

UniProtKB/Swiss-Prot for DYNC1I1 Gene

  • Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores

Gene Wiki entry for DYNC1I1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNC1I1 Gene

Genomics for DYNC1I1 Gene

Regulatory Elements for DYNC1I1 Gene

Genomic Location for DYNC1I1 Gene

Start:
95,772,506 bp from pter
End:
96,110,322 bp from pter
Size:
337,817 bases
Orientation:
Plus strand

Genomic View for DYNC1I1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DYNC1I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNC1I1 Gene

Proteins for DYNC1I1 Gene

  • Protein details for DYNC1I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14576-DC1I1_HUMAN
    Recommended name:
    Cytoplasmic dynein 1 intermediate chain 1
    Protein Accession:
    O14576
    Secondary Accessions:
    • B4DME3
    • F5H050
    • G5E9K1
    • Q8TBF7
    • Q9Y2X1

    Protein attributes for DYNC1I1 Gene

    Size:
    645 amino acids
    Molecular mass:
    72955 Da
    Quaternary structure:
    • Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity).

    Alternative splice isoforms for DYNC1I1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DYNC1I1 Gene

Proteomics data for DYNC1I1 Gene at MOPED

Post-translational modifications for DYNC1I1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DYNC1I1 Gene

Domains for DYNC1I1 Gene

Gene Families for DYNC1I1 Gene

HGNC:
  • DYN :Cytoplasmic dyneins
  • WDR :WD repeat domain containing

Protein Domains for DYNC1I1 Gene

Graphical View of Domain Structure for InterPro Entry

O14576

UniProtKB/Swiss-Prot:

DC1I1_HUMAN :
  • O14576
Family:
  • Belongs to the dynein intermediate chain family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DYNC1I1: view

Function for DYNC1I1 Gene

Molecular function for DYNC1I1 Gene

UniProtKB/Swiss-Prot Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores

Gene Ontology (GO) - Molecular Function for DYNC1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 10049579
GO:0003777 microtubule motor activity ISS --
GO:0005515 protein binding IPI 14985359
GO:0008017 microtubule binding ISS --
GO:0030507 spectrin binding IDA 23704327
genes like me logo Genes that share ontologies with DYNC1I1: view

Phenotypes for DYNC1I1 Gene

MGI mutant phenotypes for DYNC1I1:
inferred from 1 alleles
GenomeRNAi human phenotypes for DYNC1I1:
genes like me logo Genes that share phenotypes with DYNC1I1: view

miRNA for DYNC1I1 Gene

miRTarBase miRNAs that target DYNC1I1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DYNC1I1 Gene

Localization for DYNC1I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNC1I1 Gene

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNC1I1 Gene COMPARTMENTS Subcellular localization image for DYNC1I1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for DYNC1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 19229290
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IDA 19229290
GO:0005829 cytosol TAS --
GO:0005868 cytoplasmic dynein complex ISS --
genes like me logo Genes that share ontologies with DYNC1I1: view

Pathways for DYNC1I1 Gene

genes like me logo Genes that share pathways with DYNC1I1: view

Pathways by source for DYNC1I1 Gene

Gene Ontology (GO) - Biological Process for DYNC1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement --
GO:0008152 metabolic process TAS 10049579
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0047496 vesicle transport along microtubule ISS --
genes like me logo Genes that share ontologies with DYNC1I1: view

Transcripts for DYNC1I1 Gene

Unigene Clusters for DYNC1I1 Gene

Dynein, cytoplasmic 1, intermediate chain 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DYNC1I1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DYNC1I1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DYNC1I1 Gene

No ASD Table

Relevant External Links for DYNC1I1 Gene

GeneLoc Exon Structure for
DYNC1I1
ECgene alternative splicing isoforms for
DYNC1I1

Expression for DYNC1I1 Gene

mRNA expression in normal human tissues for DYNC1I1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYNC1I1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.7), Brain - Anterior cingulate cortex (BA24) (4.2), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DYNC1I1 Gene

SOURCE GeneReport for Unigene cluster for DYNC1I1 Gene Hs.440364

genes like me logo Genes that share expressions with DYNC1I1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DYNC1I1 Gene

Orthologs for DYNC1I1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DYNC1I1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNCI1 35
  • 99.79 (n)
  • 100 (a)
DNCI1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DYNC1I1 35
  • 92.05 (n)
  • 98.19 (a)
DYNC1I1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYNC1I1 35
  • 92.62 (n)
  • 99.2 (a)
DYNC1I1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dync1i1 35
  • 91.3 (n)
  • 98.09 (a)
Dync1i1 16
Dync1i1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DYNC1I1 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYNC1I1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dync1i1 35
  • 91.6 (n)
  • 98.13 (a)
chicken
(Gallus gallus)
Aves DYNC1I1 35
  • 83.89 (n)
  • 95.68 (a)
DYNC1I1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYNC1I1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dync1i1 35
  • 78.22 (n)
  • 89.46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.193 35
zebrafish
(Danio rerio)
Actinopterygii dync1i1 35
  • 73.79 (n)
  • 79.11 (a)
dync1i1 36
  • 79 (a)
OneToMany
DYNC1I1 (1 of 2) 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sdic1 36
  • 49 (a)
ManyToMany
Sdic2 36
  • 53 (a)
ManyToMany
Sdic3 36
  • 51 (a)
ManyToMany
Sdic4 36
  • 53 (a)
ManyToMany
sw 36
  • 47 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dyci-1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.507 36
  • 49 (a)
OneToMany
Species with no ortholog for DYNC1I1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DYNC1I1 Gene

ENSEMBL:
Gene Tree for DYNC1I1 (if available)
TreeFam:
Gene Tree for DYNC1I1 (if available)

Paralogs for DYNC1I1 Gene

Paralogs for DYNC1I1 Gene

Selected SIMAP similar genes for DYNC1I1 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with DYNC1I1: view

Variants for DYNC1I1 Gene

Sequence variations from dbSNP and Humsavar for DYNC1I1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs448 -- 96,092,968(-) ATAAC(C/T)TTCAC intron-variant
rs449 -- 96,092,950(-) TGTGG(A/G)GCAAT intron-variant
rs450 -- 96,092,922(-) AGAAA(G/T)GCCAG intron-variant
rs451 -- 96,092,746(-) CTCCC(A/G)GAGCC intron-variant
rs452 -- 96,092,698(-) TCAGG(G/T)ATCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYNC1I1 Gene

Variant ID Type Subtype PubMed ID
esv2734849 CNV Deletion 23290073
esv274966 CNV Gain+Loss 21479260
nsv5852 CNV Insertion 18451855
nsv527504 CNV Gain 19592680
nsv5856 CNV Insertion 18451855
esv270373 CNV Insertion 20981092

Relevant External Links for DYNC1I1 Gene

HapMap Linkage Disequilibrium report
DYNC1I1
Human Gene Mutation Database (HGMD)
DYNC1I1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYNC1I1 Gene

Disorders for DYNC1I1 Gene

Relevant External Links for DYNC1I1

Genetic Association Database (GAD)
DYNC1I1
Human Genome Epidemiology (HuGE) Navigator
DYNC1I1
genes like me logo Genes that share disorders with DYNC1I1: view

No data available for UniProtKB/Swiss-Prot for DYNC1I1 Gene

Publications for DYNC1I1 Gene

  1. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. (PMID: 10049579) Crackower M.A. … Tsui L.-C. (Genomics 1999) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 48
  5. Cytoplasmic dynein nomenclature. (PMID: 16260502) Pfister K.K. … Vallee R.B. (J. Cell Biol. 2005) 2 3

Products for DYNC1I1 Gene

Sources for DYNC1I1 Gene

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