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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DYNC1I1 Gene

protein-coding   GIFtS: 60
GCID: GC07P095401

Dynein, Cytoplasmic 1, Intermediate Chain 1

(Previous names: dynein, cytoplasmic, intermediate polypeptide 1)
(Previous symbol: DNCI1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dynein, Cytoplasmic 1, Intermediate Chain 11 2     Dynein Intermediate Chain 1, Cytosolic2 3
DNCI11 2 3 5     DNCIC12 3
Dynein, Cytoplasmic, Intermediate Polypeptide 11 2     DH IC-12 3
Cytoplasmic Dynein Intermediate Chain 12 3     Cytoplasmic Dynein 1 Intermediate Chain 12

External Ids:    HGNC: 29631   Entrez Gene: 17802   Ensembl: ENSG000001585607   OMIM: 6037725   UniProtKB: O145763   

Export aliases for DYNC1I1 gene to outside databases

Previous GC identifers: GC07P095047 GC07P095239 GC07P090008


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DYNC1I1 Gene: 
DYNC1I1 (dynein, cytoplasmic 1, intermediate chain 1) is a protein-coding gene. Diseases associated with DYNC1I1 include smallpox, and hepatocellular carcinoma, and among its related super-pathways are Immune System and Cell cycle Spindle assembly and chromosome separation. GO annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is DNAI2.

UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component
(p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles
and kinetochores

Gene Wiki entry for DYNC1I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DYNC1I1 gene promoter:
         Brachyury   Pax-2   FOXO3   Pax-2a   IRF-1   Egr-4   FOXO3b   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DYNC1I1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DYNC1I1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYNC1I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3-q22.1   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3-q22.1

DYNC1I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYNC1I1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P095401:  view genomic region     (about GC identifiers)

Start:
95,401,818 bp from pter      End:
95,739,634 bp from pter
Size:
337,817 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 94,730,870-95,056,794     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576 (See protein sequence)
Recommended Name: Cytoplasmic dynein 1 intermediate chain 1  
Size: 645 amino acids; 72955 Da
Subunit: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs)
and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs)
and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy
chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic
subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with
DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton,
spindle pole
Secondary accessions: Q9Y2X1
Alternative splicing: 3 isoforms:  O14576-1   O14576-2   O14576-3   

Explore the universe of human proteins at neXtProt for DYNC1I1: NX_O14576

Explore proteomics data for DYNC1I1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14576

  • DYNC1I1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DYNC1I1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001129028.1  NP_001129029.1  NP_001265350.1  NP_001265351.1  NP_004402.1  

    ENSEMBL proteins: 
     ENSP00000392337   ENSP00000428934   ENSP00000320130   ENSP00000398118   ENSP00000352348  
     ENSP00000411957   ENSP00000428273   ENSP00000412444   ENSP00000438377  
    Reactome Protein details: O14576
    Human Recombinant Protein Products for DYNC1I1: 
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    Cloud-Clone Corp. Proteins for DYNC1I1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA19229290
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000922spindle pole IDA19229290
    GO:0005829cytosol TAS--
    GO:0005868cytoplasmic dynein complex ISS--

    DYNC1I1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing
    DYN: Cytoplasmic dyneins

    4 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR025956 Dynein_IC_1/2
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O14576

    ProtoNet protein and cluster: O14576

    UniProtKB/Swiss-Prot: DC1I1_HUMAN, O14576
    Similarity: Belongs to the dynein intermediate chain family
    Similarity: Contains 7 WD repeats


    DYNC1I1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DC1I1_HUMAN, O14576
    Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are
    thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.
    Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along
    microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component
    (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles
    and kinetochores

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity TAS10049579
    GO:0003777microtubule motor activity ISS--
    GO:0005515protein binding IPI14985359
    GO:0008017microtubule binding ISS--
         
    DYNC1I1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DYNC1I1:
     Decreased Hepatitis C virus re  Decreased influenza A virus in 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidDYNC1I1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DYNC1I1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94
    3Regulation of degradation of wt-CFTR
    Regulation of degradation of deltaF508 CFTR in CF0.59
    4Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32
    5MHC class II antigen presentation
    MHC class II antigen presentation0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DYNC1I1
        Cell cycle Spindle assembly and chromosome separation
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DYNC1I1
        Cell cycle Spindle assembly and chromosome separation
    Regulation of degradation of deltaF508 CFTR in CF


    3        Reactome Pathways for DYNC1I1
        Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    3         Kegg Pathways  (Kegg details for DYNC1I1):
        Phagosome
    Vasopressin-regulated water reabsorption
    Salmonella infection


    DYNC1I1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYNC1I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for DYNC1I1 (O145762, 3 ENSP000003201304) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN1Q142032, 3, ENSP000003547914MINT-7899583 MINT-4049943 MINT-7899565 MINT-8254844 I2D: score=2 STRING: ENSP00000354791
    SMN1Q166372, 3MINT-8271080 I2D: score=2 
    SMN2Q166372, 3MINT-8271080 I2D: score=2 
    GSK3BP498412, 3, ENSP000003248064MINT-4049943 I2D: score=1 STRING: ENSP00000324806
    TP53P046372, 3, ENSP000002693054MINT-1891331 I2D: score=1 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--
    GO:0047496vesicle transport along microtubule ISS--

    DYNC1I1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DYNC1I1 (DC1I1)

    Search CenterWatch for drugs/clinical trials and news about DYNC1I1 / DC1I1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DYNC1I1 gene (5 alternative transcripts): 
    NM_001135556.1  NM_001135557.1  NM_001278421.1  NM_001278422.1  NM_004411.4  

    Unigene Cluster for DYNC1I1:

    Dynein, cytoplasmic 1, intermediate chain 1
    Hs.440364  [show with all ESTs]
    Unigene Representative Sequence: NM_004411
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447467(uc003uod.4 uc003uob.3 uc010lfl.3) ENST00000524053
    ENST00000324972(uc003uoc.4) ENST00000437599(uc003uoe.4) ENST00000359388
    ENST00000413338 ENST00000518089 ENST00000457059 ENST00000519371 ENST00000497626
    ENST00000537881
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    Additional mRNA sequence: 

    AF063228.1 AF123074.1 AK091339.1 AK297427.1 AK309419.1 AK313148.1 BC012504.1 BC022540.1 
    BC032945.2 BC037854.1 BC053542.1 

    13 DOTS entries:

    DT.95366249  DT.100022912  DT.311446  DT.100780212  DT.40121523  DT.95105413  DT.95366303  DT.100780213 
    DT.121066010  DT.121066044  DT.121066067  DT.121066097  DT.99992389 

    24/111 AceView cDNA sequences (see all 111):

    F05202 AL119852 CB155827 BM013807 AW512007 AA370850 AK091339 AI702010 
    AI631131 CB156258 F03883 AW160882 BM715981 CD676444 BU733433 AI917122 
    BE671718 AI923516 AI810807 AI817595 F01454 CD676815 BQ003509 Z40531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DYNC1I1 expression in normal human tissues (normalized intensities)      DYNC1I1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCTTTAG
    DYNC1I1 Expression
    About this image


    DYNC1I1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
             limb/hindlimb/leg   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             HyStem+BMP4-induced MEL2 cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
             brain/midbrain/lateral wall   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             cavities and their linings/intraembryonic coelom/diaphragm   

    See DYNC1I1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DYNC1I1

    SOURCE GeneReport for Unigene cluster: Hs.440364
        SABiosciences Custom PCR Arrays for DYNC1I1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DYNC1I1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dync1i11 , 5 dynein cytoplasmic 1 intermediate chain 11, 5 91.25(n)1
    98.06(a)1
      6 (2.26 cM)5
    134261  NM_001191026.11  NP_001177955.11 
     57256395 
    chicken
    (Gallus gallus)
    Aves DYNC1I11 dynein, cytoplasmic 1, intermediate chain 1 84.08(n)
    95.81(a)
      420571  XM_418672.3  XP_418672.2 
    lizard
    (Anolis carolinensis)
    Reptilia DYNC1I16
    Uncharacterized protein
    96(a)
    1 ↔ 1
    6(22623203-22832757)
    zebrafish
    (Danio rerio)
    Actinopterygii dync1i11 dynein, cytoplasmic 1, intermediate chain 1 74.22(n)
    79.43(a)
      561525  NM_001079990.1  NP_001073459.1 


    ENSEMBL Gene Tree for DYNC1I1 (if available)
    TreeFam Gene Tree for DYNC1I1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DYNC1I1 gene
    DNAI22  DNAI12  WDR342  DYNC1I22  WDR782  
    3 SIMAP similar genes for DYNC1I1 using alignment to 10 protein entries:     DC1I1_HUMAN (see all proteins):
    DNCI1    DNCI2    DYNC1I2

    DYNC1I1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6075 SNPs in DYNC1I1 are shown (see all 6075)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0647094
    ----see VAR_0647092 H L mis40--------
    rs350268041,2
    C--95040294(+) AAAAA-/A/AA  
            
    TCTCT
    3 -- int11NA 2
    rs1409511901,2
    --95399883(+) ACACTC/GGTGAG 3 -- us2k10--------
    rs1911849061,2
    --95399912(+) GCCTCC/TGCCCC 3 -- us2k10--------
    rs1833577601,2
    --95399975(+) TACTTC/TGTGGG 3 -- us2k10--------
    rs1157004591,2
    F--95399976(+) ACTTCG/ATGGGC 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1999844161,2
    C--95400057(+) GGCAGG/TCAGAT 3 -- us2k10--------
    rs1467278951,2
    --95400140(+) TTAGCC/TGGGCT 3 -- us2k10--------
    rs1403693471,2
    --95400173(+) TAGCTA/GCTCAG 3 -- us2k10--------
    rs77960391,2
    C,F--95400211(+) cccagG/Cagatg 3 -- us2k16Minor allele frequency- C:0.50NA CSA 12

    HapMap Linkage Disequilibrium report for DYNC1I1 (95401818 - 95651818 bp, first 250kb of DYNC1I1)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DYNC1I1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734849CNV Deletion23290073
    esv270373CNV Insertion20981092
    nsv5852CNV Insertion18451855
    nsv5856CNV Insertion18451855
    nsv527504CNV Gain19592680
    esv274966CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603772    OMIM disorders: --

    2 diseases for DYNC1I1:    About MalaCards
    smallpox    hepatocellular carcinoma


    DYNC1I1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DYNC1I1
    Human Genome Epidemiology (HuGE) Navigator: DYNC1I1 (2 documents)

    Export disorders for DYNC1I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DYNC1I1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with DYNC1I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. (PubMed id 10049579)1, 2, 3 Crackower M.A.... Tsui L.-C. (1999)
    2. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    3. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint. (PubMed id 19229290)1, 2 Sivaram M.V....Doxsey S.J. (2009)
    4. Cytoplasmic dynein nomenclature. (PubMed id 16260502)1, 3 Pfister K.K....Vallee R.B. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    8. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    9. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1780 HGNC: 2963 AceView: DNCI1 Ensembl:ENSG00000158560 euGenes: HUgn1780
    ECgene: DYNC1I1 Kegg: 1780 H-InvDB: DYNC1I1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DYNC1I1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DYNC1I1 gene:
    Search GeneIP for patents involving DYNC1I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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