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Aliases for DYNAP Gene

Aliases for DYNAP Gene

  • Dynactin Associated Protein 2 3 5
  • C18orf26 3 4
  • Full 3 4
  • Chromosome 18 Open Reading Frame 26 2

External Ids for DYNAP Gene

Previous HGNC Symbols for DYNAP Gene

  • C18orf26

Previous GeneCards Identifiers for DYNAP Gene

  • GC18P052254
  • GC18P054587

Summaries for DYNAP Gene

GeneCards Summary for DYNAP Gene

DYNAP (Dynactin Associated Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DYNAP Gene

  • Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at Ser-473.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYNAP Gene

Genomics for DYNAP Gene

Genomic Location for DYNAP Gene

Chromosome:
18
Start:
54,532,713 bp from pter
End:
54,599,493 bp from pter
Size:
66,781 bases
Orientation:
Plus strand

Genomic View for DYNAP Gene

Genes around DYNAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYNAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYNAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYNAP Gene

No data available for Regulatory Elements for DYNAP Gene

Proteins for DYNAP Gene

  • Protein details for DYNAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1N2-DYNAP_HUMAN
    Recommended name:
    Dynactin-associated protein
    Protein Accession:
    Q8N1N2

    Protein attributes for DYNAP Gene

    Size:
    210 amino acids
    Molecular mass:
    22529 Da
    Quaternary structure:
    • Interacts with DCTN1 and DCTN2.

neXtProt entry for DYNAP Gene

Proteomics data for DYNAP Gene at MOPED

Post-translational modifications for DYNAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DYNAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DYNAP Gene

Domains & Families for DYNAP Gene

Protein Domains for DYNAP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DYNAP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DYNAP Gene

Function for DYNAP Gene

Molecular function for DYNAP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at Ser-473.

Phenotypes for DYNAP Gene

genes like me logo Genes that share phenotypes with DYNAP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DYNAP Gene

Localization for DYNAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DYNAP Gene

Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYNAP Gene COMPARTMENTS Subcellular localization image for DYNAP gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for DYNAP Gene

Pathways & Interactions for DYNAP Gene

SuperPathways for DYNAP Gene

No Data Available

Interacting Proteins for DYNAP Gene

Gene Ontology (GO) - Biological Process for DYNAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 20978158
genes like me logo Genes that share ontologies with DYNAP: view

No data available for Pathways by source and SIGNOR curated interactions for DYNAP Gene

Drugs & Compounds for DYNAP Gene

No Compound Related Data Available

Transcripts for DYNAP Gene

mRNA/cDNA for DYNAP Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DYNAP Gene

Dynactin associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYNAP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for DYNAP Gene

GeneLoc Exon Structure for
DYNAP
ECgene alternative splicing isoforms for
DYNAP

Expression for DYNAP Gene

mRNA expression in normal human tissues for DYNAP Gene

mRNA differential expression in normal tissues according to GTEx for DYNAP Gene

This gene is overexpressed in Esophagus - Mucosa (x41.9) and Minor Salivary Gland (x6.9).

SOURCE GeneReport for Unigene cluster for DYNAP Gene Hs.376146

mRNA Expression by UniProt/SwissProt for DYNAP Gene

Q8N1N2-DYNAP_HUMAN
Tissue specificity: Expressed in fibroblast and numerous cancer cell lines (at protein level).
genes like me logo Genes that share expression patterns with DYNAP: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DYNAP Gene

Orthologs for DYNAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for DYNAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DYNAP 35
  • 96.71 (n)
  • 94.08 (a)
DYNAP 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for DYNAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DYNAP Gene

ENSEMBL:
Gene Tree for DYNAP (if available)
TreeFam:
Gene Tree for DYNAP (if available)

Paralogs for DYNAP Gene

Pseudogenes.org Pseudogenes for DYNAP Gene

genes like me logo Genes that share paralogs with DYNAP: view

No data available for Paralogs for DYNAP Gene

Variants for DYNAP Gene

Sequence variations from dbSNP and Humsavar for DYNAP Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35428499 - 54,591,317(+) GAACG(C/T)TGAGC upstream-variant-2KB, reference, missense
rs9947055 - 54,598,077(+) CTACA(A/C)CTTCA reference, missense
rs896517 -- 54,578,221(+) TGTCT(A/G)TGGGA intron-variant
rs896518 -- 54,579,931(+) CTCTA(A/G)AAATT intron-variant
rs896519 -- 54,580,762(+) GCCAA(A/C)AATAA intron-variant

Variation tolerance for DYNAP Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYNAP Gene

HapMap Linkage Disequilibrium report
DYNAP
Human Gene Mutation Database (HGMD)
DYNAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DYNAP Gene

Disorders for DYNAP Gene

Relevant External Links for DYNAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYNAP

No disorders were found for DYNAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DYNAP Gene

Publications for DYNAP Gene

  1. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. (PMID: 20978158) Kunoh T. … Mizukami T. (Mol. Cancer Ther. 2010) 2 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for DYNAP Gene

Sources for DYNAP Gene

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