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Aliases for DYDC2 Gene

Aliases for DYDC2 Gene

  • DPY30 Domain Containing 2 2 3 5

External Ids for DYDC2 Gene

Previous GeneCards Identifiers for DYDC2 Gene

  • GC10U900484
  • GC10P082095
  • GC10P075959

Summaries for DYDC2 Gene

Entrez Gene Summary for DYDC2 Gene

  • This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for DYDC2 Gene

DYDC2 (DPY30 Domain Containing 2) is a Protein Coding gene. Diseases associated with DYDC2 include myofibrillar myopathy. An important paralog of this gene is DYDC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DYDC2 Gene

Genomics for DYDC2 Gene

Regulatory Elements for DYDC2 Gene

Genomic Location for DYDC2 Gene

Chromosome:
10
Start:
80,344,745 bp from pter
End:
80,368,118 bp from pter
Size:
23,374 bases
Orientation:
Plus strand

Genomic View for DYDC2 Gene

Genes around DYDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DYDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DYDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DYDC2 Gene

Proteins for DYDC2 Gene

  • Protein details for DYDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IM9-DYDC2_HUMAN
    Recommended name:
    DPY30 domain-containing protein 2
    Protein Accession:
    Q96IM9
    Secondary Accessions:
    • D3DWD6
    • Q5QP07
    • Q5QP11

    Protein attributes for DYDC2 Gene

    Size:
    177 amino acids
    Molecular mass:
    20586 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI13698.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DYDC2 Gene

Proteomics data for DYDC2 Gene at MOPED

Post-translational modifications for DYDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DYDC2 Gene

Domains & Families for DYDC2 Gene

Protein Domains for DYDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DYDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IM9

UniProtKB/Swiss-Prot:

DYDC2_HUMAN :
  • Belongs to the dpy-30 family.
Family:
  • Belongs to the dpy-30 family.
genes like me logo Genes that share domains with DYDC2: view

No data available for Gene Families for DYDC2 Gene

Function for DYDC2 Gene

genes like me logo Genes that share phenotypes with DYDC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DYDC2 Gene

Localization for DYDC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DYDC2 Gene COMPARTMENTS Subcellular localization image for DYDC2 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DYDC2 Gene

Pathways & Interactions for DYDC2 Gene

SuperPathways for DYDC2 Gene

No Data Available

Interacting Proteins for DYDC2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256039%0d%0a9606.ENSP00000265191%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: Q96IM9-DYDC2_HUMAN ENSP00000256039 for DYDC2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for DYDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DYDC2 Gene

Drugs & Compounds for DYDC2 Gene

No Compound Related Data Available

Transcripts for DYDC2 Gene

mRNA/cDNA for DYDC2 Gene

Unigene Clusters for DYDC2 Gene

DPY30 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DYDC2 Gene

No ASD Table

Relevant External Links for DYDC2 Gene

GeneLoc Exon Structure for
DYDC2
ECgene alternative splicing isoforms for
DYDC2

Expression for DYDC2 Gene

mRNA expression in normal human tissues for DYDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DYDC2 Gene

This gene is overexpressed in Fallopian Tube (x7.2), Brain - Nucleus accumbens (basal ganglia) (x7.0), Brain - Caudate (basal ganglia) (x6.3), Brain - Hypothalamus (x5.2), Testis (x4.4), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for DYDC2 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DYDC2 Gene



SOURCE GeneReport for Unigene cluster for DYDC2 Gene Hs.741500

genes like me logo Genes that share expression patterns with DYDC2: view

Protein tissue co-expression partners for DYDC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DYDC2 Gene

Orthologs for DYDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DYDC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DYDC2 35
  • 80.19 (n)
  • 68 (a)
DYDC2 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DYDC2 35
  • 82.96 (n)
  • 72.47 (a)
DYDC2 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dydc2 35
  • 74.34 (n)
  • 58.99 (a)
Dydc2 16
Dydc2 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DYDC2 35
  • 99.13 (n)
  • 97.38 (a)
DYDC2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dydc2 35
  • 70.26 (n)
  • 53.24 (a)
oppossum
(Monodelphis domestica)
Mammalia DYDC2 36
  • 27 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DYDC2 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DYDC2 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DYDC2 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for DYDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DYDC2 Gene

ENSEMBL:
Gene Tree for DYDC2 (if available)
TreeFam:
Gene Tree for DYDC2 (if available)

Paralogs for DYDC2 Gene

Paralogs for DYDC2 Gene

(1) SIMAP similar genes for DYDC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DYDC2: view

Variants for DYDC2 Gene

Sequence variations from dbSNP and Humsavar for DYDC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1047951 - 80,366,844(+) CTGCT(A/G)GCCAG intron-variant, nc-transcript-variant, reference, missense
rs1047952 -- 80,367,052(+) AAGTT(C/G)AGGGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs946892 -- 80,367,795(-) TTGAA(A/G)AAAAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1538818 -- 80,363,037(-) TGATA(C/T)TCTTC nc-transcript-variant, reference, synonymous-codon
rs1538819 -- 80,362,767(-) GAAGC(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DYDC2 Gene

Variant ID Type Subtype PubMed ID
nsv831923 CNV Loss 17160897
nsv825479 CNV Gain 20364138

Variation tolerance for DYDC2 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DYDC2 Gene

HapMap Linkage Disequilibrium report
DYDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DYDC2 Gene

Disorders for DYDC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DYDC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myofibrillar myopathy
  • desminopathy
- elite association - COSMIC cancer census association via MalaCards
Search DYDC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DYDC2

Genetic Association Database (GAD)
DYDC2
Human Genome Epidemiology (HuGE) Navigator
DYDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DYDC2
genes like me logo Genes that share disorders with DYDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DYDC2 Gene

Publications for DYDC2 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Shifted Transversal Design smart-pooling for high coverage interactome mapping. (PMID: 19447967) Xin X. … Thierry-Mieg N. (Genome Res. 2009) 3
  4. Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. (PMID: 18197198) Kuhl A. … Jenne D.E. (Eur. J. Hum. Genet. 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DYDC2 Gene

Sources for DYDC2 Gene

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