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DYDC2 Gene

protein-coding   GIFtS: 44
GCID: GC10P082095

DPY30 Domain Containing 2

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DPY30 Domain Containing 21 2
DPY30 Domain-Containing Protein 22

External Ids:    HGNC: 234681   Entrez Gene: 843322   Ensembl: ENSG000001336657   UniProtKB: Q96IM93   

Export aliases for DYDC2 gene to outside databases

Previous GC identifers: GC10U900484 GC10P075959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DYDC2 Gene:
This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a
closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jun 2012)

GeneCards Summary for DYDC2 Gene:
DYDC2 (DPY30 domain containing 2) is a protein-coding gene. Diseases associated with DYDC2 include myofibrillar myopathy, and myopathy. An important paralog of this gene is DYDC1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DYDC2 gene promoter:
         POU3F2 (N-Oct-5b)   Nkx5-1   FOXL1   NF-AT   NF-AT4   NF-AT2   HFH-1   NF-AT3   Chx10   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDYDC2 promoter sequence
   Search Chromatin IP Primers for DYDC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DYDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.1   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q23.1

DYDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYDC2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P082095:  view genomic region     (about GC identifiers)

Start:
82,104,501 bp from pter      End:
82,127,829 bp from pter
Size:
23,329 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DYDC2_HUMAN, Q96IM9 (See protein sequence)
Recommended Name: DPY30 domain-containing protein 2  
Size: 177 amino acids; 20586 Da
Sequence caution: Sequence=CAI13698.1; Type=Erroneous initiation;
Secondary accessions: D3DWD6 Q5QP07 Q5QP11

Explore the universe of human proteins at neXtProt for DYDC2: NX_Q96IM9

Explore proteomics data for DYDC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DYDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001256970.1  NP_001256971.1  NP_115748.1  

    ENSEMBL proteins: 
     ENSP00000361273   ENSP00000361272   ENSP00000361271   ENSP00000401333   ENSP00000256039  
     ENSP00000410285  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007858 Dpy-30_motif

    Graphical View of Domain Structure for InterPro Entry Q96IM9

    ProtoNet protein and cluster: Q96IM9

    UniProtKB/Swiss-Prot: DYDC2_HUMAN, Q96IM9
    Similarity: Belongs to the dpy-30 family


    DYDC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DYDC2
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    SwitchGear 3'UTR luciferase reporter plasmidDYDC2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DYDC2
    Interactions:

        Search GeneGlobe Interaction Network for DYDC2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DYDC2 (Q96IM93 ENSP000002560394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME5P565973, ENSP000002651914I2D: score=4 STRING: ENSP00000265191
    SIRT5ENSP000003685524STRING: ENSP00000368552
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DYDC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DYDC2 gene (3 alternative transcripts): 
    NM_001270041.1  NM_001270042.1  NM_032372.5  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372199(uc001kbz.1 uc001kca.1) ENST00000372198 ENST00000372197
    ENST00000411538 ENST00000256039(uc001kcb.1) ENST00000444807

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate DYDC2:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidDYDC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DYDC2
    Predesigned siRNA for gene silencing in human, mouse, rat DYDC2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DYDC2 (NM_032372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DYDC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYDC2
    Primer
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    OriGene qPCR primer pairs and template standards for DYDC2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DYDC2
      QuantiTect SYBR Green Assays in human, mouse, rat DYDC2
      QuantiFast Probe-based Assays in human, mouse, rat DYDC2

    12 AceView cDNA sequences:

    BQ188773 D81849 BU172394 BE894515 BC007374 BC018606 AK093378 NM_032372 
    AX748088 CK301146 BX089251 BM979804 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DYDC2 expression in normal human tissues (normalized intensities)      DYDC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACATTTG
    DYDC2 Expression
    About this image


    DYDC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
    DYDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DYDC2 Protein Expression
        Custom PCR Arrays for DYDC2
    Primer
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    OriGene qPCR primer pairs and template standards for DYDC2
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    QuantiFast Probe-based Assays in human, mouse, rat DYDC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DYDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DYDC2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dydc21 , 5 DPY30 domain containing 21, 5 74.34(n)1
    58.99(a)1
      14 (22.36 cM)5
    712001  NM_027717.11  NP_081993.11 
     410492095 
    lizard
    (Anolis carolinensis)
    Reptilia DYDC26
    DPY30 domain containing 2
    40(a)
    1 ↔ 1
    GL343233.1(1801417-1801790)
    zebrafish
    (Danio rerio)
    Actinopterygii DYDC26
    DPY30 domain containing 2
    21(a)
    1 → many
    12(49041230-49046526) ENSDARG00000091663


    ENSEMBL Gene Tree for DYDC2 (if available)
    TreeFam Gene Tree for DYDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DYDC2 gene
    DYDC12  
    1 SIMAP similar gene for DYDC2 using alignment to 1 protein entry:     DYDC2_HUMAN:
    DYDC1

    DYDC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DYDC2 (see all 255)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903593961,2
    --82118557(+) ATGAAA/GCCGTG 5 -- int10--------
    rs1155103611,2
    F--82118558(+) TGAAGC/ACGTGG 5 -- int11Minor allele frequency- A:0.03WA 118
    rs1422577311,2
    --82118560(+) AAGCCA/GTGGAC 5 -- int10--------
    rs1147845261,2
    F--82118572(+) CTCACA/GGTGAG 5 -- int12Minor allele frequency- G:0.05WA NA 238
    rs1817590641,2
    --82118575(+) ACAGTA/GAGTAT 5 -- int10--------
    rs1843656931,2
    --82118597(+) AAGGCA/GGCGTG 5 -- int10--------
    rs618591991,2
    C,F--82118613(+) AGTTCA/G/TTTCCT 5 -- int14CSA WA NA EA 360
    rs1180451251,2
    F--82118677(+) CCTTCA/GGAAGT 5 -- int11Minor allele frequency- G:0.01EA 120
    rs1887048481,2
    --82118706(+) AGTGAA/GTGTTA 5 -- int10--------
    rs1811294421,2
    --82118744(+) ACAATA/GAGCAG 5 -- int10--------

    HapMap Linkage Disequilibrium report for DYDC2 (82104501 - 82127829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DYDC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831923CNV Loss17160897
    nsv825479CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DYDC2
    DNA2.0 Custom Variant and Variant Library Synthesis for DYDC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for DYDC2:    About MalaCards
    myofibrillar myopathy    myopathy    alzheimer's disease


    DYDC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DYDC2
    Human Genome Epidemiology (HuGE) Navigator: DYDC2 (1 document)

    Export disorders for DYDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DYDC2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DYDC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Shifted Transversal Design smart-pooling for high coverage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (Genome Res. 2009)
    7. Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. (PubMed id 18197198)1 Kuhl A....Jenne D.E. (Eur. J. Hum. Genet. 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84332 HGNC: 23468 AceView: MGC16186 Ensembl:ENSG00000133665 euGenes: HUgn84332
    ECgene: DYDC2 H-InvDB: DYDC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DYDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DYDC2 gene:
    Search GeneIP for patents involving DYDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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