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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DYDC2 Gene

protein-coding GIFtS: 43
GCID: GC10P082095

DPY30 domain containing 2

Explore 4 diseases affiliated with
DYDC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DPY30 Domain Containing 2¹ ²
MGC16186¹
BA36D19.6¹
DPY30 Domain-Containing Protein 2²

External Ids:	HGNC: 23468¹	Entrez Gene: 84332²	Ensembl: ENSG00000133665⁷	UniProtKB: Q96IM9³

Export aliases for DYDC2 gene to outside databases

Previous GC identifers: GC10U900484 GC10P075959

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DYDC2:

This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a

closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. (provided

by RefSeq, Jun 2012)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DYDC2 gene promoter:
POU3F2 (N-Oct-5b) Nkx5-1 FOXL1 NF-AT NF-AT4 NF-AT2 HFH-1 NF-AT3 Chx10 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DYDC2 promoter sequence

Search SABiosciences Chromatin IP Primers for DYDC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYDC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.1 Ensembl cytogenetic band: 10q23.1 HGNC cytogenetic band: 10q23.1

DYDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DYDC2 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P082095: view genomic region (about GC identifiers)

Start:	82,104,501 bp from pter	End:	82,127,829 bp from pter
Size:	23,329 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DYDC2_HUMAN, Q96IM9 (See protein sequence)

Recommended Name: DPY30 domain-containing protein 2

Size: 177 amino acids; 20586 Da

Sequence caution: Sequence=CAI13698.1; Type=Erroneous initiation;

Secondary accessions: D3DWD6 Q5QP07 Q5QP11

Explore the universe of human proteins at neXtProt for DYDC2: NX_Q96IM9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96IM9

DYDC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001256970.1 NP_001256971.1 NP_115748.1

ENSEMBL proteins:

ENSP00000361273 ENSP00000361272 ENSP00000361271 ENSP00000401333 ENSP00000256039

ENSP00000410285

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DYDC2 for domains About GeneDecksing

1 InterPro domain/family:

IPR007858 Dpy-30_motif

Graphical View of Domain Structure for InterPro Entry Q96IM9

ProtoNet protein and cluster: Q96IM9

UniProtKB/Swiss-Prot: DYDC2_HUMAN, Q96IM9

Similarity: Belongs to the dpy-30 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DYDC2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DYDC2:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DYDC2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for DYDC2 (Q96IM9³ ENSP00000256039⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME5	P56597³, ENSP00000265191⁴	I2D: score=4 STRING: ENSP00000265191
SIRT5	ENSP00000368552⁴	STRING: ENSP00000368552

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DYDC2
Search CenterWatch for drugs/clinical trials and news about DYDC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for DYDC2 gene (3 alternative transcripts):

NM_001270041.1 NM_001270042.1 NM_032372.5

Unigene Cluster for DYDC2:

DPY30 domain containing 2

Hs.741500 [show with all ESTs]

Unigene Representative Sequence: BC018606

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000372199(uc001kbz.1 uc001kca.1) ENST00000372198 ENST00000372197

ENST00000411538 ENST00000256039(uc001kcb.1) ENST00000444807

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DYDC2:
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Additional cDNA sequence:

AK093378.1 BC007374.2 BC018606.2 NR_070308.1 NR_070309.1

4 DOTS entries:

DT.100748996 DT.91750071 DT.100748995 DT.307488

12 AceView cDNA sequences:

BQ188773 D81849 BE894515 BU172394 BC007374 BC018606 NM_032372 AK093378

AX748088 CK301146 BM979804 BX089251

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DYDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAACATTTG

About this image

DYDC2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DYDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYDC2

SOURCE GeneReport for Unigene cluster: Hs.741500

SABiosciences Custom PCR Arrays for DYDC2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DYDC2 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dydc2^{1 , 5}	DPY30 domain containing 2^{1, 5}	74.34(n)¹ 58.99(a)¹		14 (22.36 cM)⁵ 71200¹ NM_027717.1¹ NP_081993.1¹ 41049209⁵
lizard (Anolis carolinensis)	Reptilia	DYDC2⁶	--	40(a)	1 ↔ 1	GL343233.1(1801417-1801790)
zebrafish (Danio rerio)	Actinopterygii	CABZ01084340.1⁶	--	17(a)	1 → many	12(49041230-49046526)

ENSEMBL Gene Tree for DYDC2 (if available)
TreeFam Gene Tree for DYDC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DYDC2 gene

DYDC1²

1 SIMAP similar gene for DYDC2 using alignment to 1 protein entry: DYDC2_HUMAN:

DYDC1

DYDC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150777981^1,2		--	82102514(+)	`GGCAGA/GTCATC`	5	--	us2k¹ int¹		0	--	--	--	--
rs61591038^1,2		--	82102577(+)	`ACTAAA/GAATAC`	5	--	int¹ us2k¹		0	--	--	--	--
rs149908062^1,2		--	82102610(+)	`CACATA/GCCTGT`	5	--	us2k¹ int¹		0	--	--	--	--
rs184921859^1,2		--	82102823(+)	`TCAGCA/CTATCT`	5	--	int¹ us2k¹		0	--	--	--	--
rs189815603^1,2		--	82102828(+)	`ATATCA/TGTCAC`	5	--	us2k¹ int¹		0	--	--	--	--
rs12411787^1,2	H	--	82102863(+)	`gcctgT/Ggggcc`	5	--	us2k¹ int¹		4		NS EA	418
rs147154817^1,2		--	82102975(+)	`GAAAAC/TGGTAT`	5	--	us2k¹ int¹		0	--	--	--	--
rs181051750^1,2		--	82102976(+)	`AAAACA/GGTATG`	5	--	us2k¹ int¹		0	--	--	--	--
rs72815334^1,2	C,	--	82103073(+)	`GCCATA/GGCAGA`	5	--	us2k¹ int¹		0	--	--	--	--
rs12411833^1,2	C,F,H,	--	82103230(+)	`ATCCAT/CTATGT`	5	--	int¹ us2k¹		20		NS EA NA WA CSA	2346

HapMap Linkage Disequilibrium report for DYDC2 (82104501 - 82127829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DYDC2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DYDC2 for disorders About GeneDecksing

4 diseases for DYDC2: About MalaCards

alzheimer's disease myofibrillar myopathy myopathy cardiomyopathy

Human Genome Epidemiology (HuGE) Navigator: DYDC2 (1 document)

Export disorders for DYDC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DYDC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DYDC2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)¹ Xin X....Thierry-Mieg N. (2009)
Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. (PubMed id 18197198)¹ Kuhl A....Jenne D.E. (2008)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84332	HGNC: 23468	AceView: MGC16186	Ensembl:ENSG00000133665	euGenes: HUgn84332
ECgene: DYDC2	H-InvDB: DYDC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DYDC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DYDC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DYDC2 gene:
Search GeneIP for patents involving DYDC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYDC2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DYDC2 gene at Home site.

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DYDC2 Gene

DPY30 domain containing 2

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DYDC2 Gene

DPY30 domain containing 2

Aliasesfor DYDC2 gene

Summariesfor DYDC2 gene

Genomic Viewsfor DYDC2 gene

Proteinsfor DYDC2 gene

Protein Domains /Familiesfor DYDC2 gene

Functionfor DYDC2 gene

Pathways & Interactionsfor DYDC2 gene

Drugs & Compoundsfor DYDC2 gene

Transcriptsfor DYDC2 gene

Expression for DYDC2 gene

Orthologsfor DYDC2 gene

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Genomic Variantsfor DYDC2 gene

Disorders / Diseasesfor DYDC2 gene

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External Searches for DYDC2 gene

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Specialized Databases showing DYDC2 gene

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for DYDC2 gene

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for DYDC2 gene

Genomic Views
for DYDC2 gene

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for DYDC2 gene

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Families
for DYDC2 gene

Function
for DYDC2 gene

Pathways & Interactions
for DYDC2 gene

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for DYDC2 gene

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for DYDC2 gene

Expression
for DYDC2 gene

Orthologs
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for DYDC2 gene

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