DYDC1 Gene
protein-coding GIFtS: 43
GCID: GC10M082086
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|
DPY30 domain containing 1
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Aliases
for DYDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DPY30 Domain Containing 11 2 | | DPY30D11 2 3 | | BA36D19.51 | | DPY30 Domain-Containing Protein 12 |
Export aliases for DYDC1 gene to outside databasesPrevious GC identifers: GC10U900476 GC10M075939 |
Summaries
for DYDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DYDC1:
This gene encodes a member of a family of proteins that contains a DPY30 domain. The encoded protein is involved inacrosome formation during spermatid development. This gene locus overlaps with a closely related gene on the oppositestrand. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jun 2012)
UniProtKB/Swiss-Prot: DYDC1_HUMAN, Q8WWB3Function: Plays a crucial role during acrosome biogenesis
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Genomic Views
for DYDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DYDC1 gene promoter:
Nkx5-1 E47 NF-AT NF-AT4 NF-AT2 HFH-1 NF-AT3 Hand1 Chx10 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DYDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DYDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.1 Ensembl cytogenetic band: 10q23.1 HGNC cytogenetic band: 10q22.3DYDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M082086: view genomic region
(about GC identifiers)
Start:
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82,095,861 bp from pter |
End:
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82,116,511 bp from pter |
Size:
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20,651 bases |
Orientation:
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minus strand |
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Proteins
for DYDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DYDC1_HUMAN, Q8WWB3 (See
protein sequence)Recommended Name: DPY30 domain-containing protein 1 Size: 177 amino acids; 20893 Da
Subunit: Interacts with SH3GL3
Caution: Sequence AAQ84766 was incorrectly indicated as originating from mouse
Sequence caution: Sequence=BAC86339.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q5QP03 Q5QP04 Q6WNP4 Q6ZU87Explore the universe of human proteins at neXtProt for DYDC1: NX_Q8WWB3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWB3
DYDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001255982.1 NP_620167.1
ENSEMBL proteins: ENSP00000361278 ENSP00000361276 ENSP00000414798 ENSP00000388160 ENSP00000402890
Human Recombinant Protein Products for DYDC1:
DYDC1 Antibody Products:
Assay Products for DYDC1: |
Protein
Domains /
Families
for DYDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DYDC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WWB3ProtoNet protein and cluster: Q8WWB3 UniProtKB/Swiss-Prot: DYDC1_HUMAN, Q8WWB3Similarity: Belongs to the dpy-30 family |
Function
for DYDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DYDC1_HUMAN, Q8WWB3Function: Plays a crucial role during acrosome biogenesisAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DYDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYDC1 |
|
Pathways & Interactions
for DYDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DYDC1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for DYDC1 (Q8WWB32, 3 ENSP000003612764) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DYDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DYDC1
Search CenterWatch for drugs/clinical trials and news about DYDC1
|
Transcripts
for DYDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DYDC1 gene (2 alternative transcripts): NM_001269053.1 NM_138812.3 Unigene Cluster for DYDC1: DPY30 domain containing 1 Hs.407751 [show with all ESTs]Unigene Representative Sequence: AK1259085 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372204(uc001kbx.3) ENST00000372202 ENST00000454362 ENST00000453477
ENST00000421924(uc001kby.1 uc009xsr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DYDC1 (NM_138812) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DYDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYDC1 |
Additional cDNA sequence: AK125908.1 AK292542.1 BC019250.1 4 DOTS entries: DT.97808345 DT.40127509 DT.100740807 DT.95363590 11 AceView cDNA sequences: BC019250 BI829226 AL040530 BI828082 NM_138812 BG718556 BI559804 AA906283 BX102394 AK125908 BI546816
GeneLoc Exon Structure
|
Expression
for DYDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DYDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACAACTGA
About this image
See DYDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DYDC1
SOURCE GeneReport for Unigene cluster: Hs.407751
UniProtKB/Swiss-Prot: DYDC1_HUMAN, Q8WWB3Tissue specificity: Brain and testis. Accumulates during late stage of spermiogenesis
SABiosciences Custom PCR Arrays for DYDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DYDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DYDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DYDC1 |
Orthologs
for DYDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DYDC1 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for DYDC1 (if available)
TreeFam Gene Tree for DYDC1 (if available) |
Paralogs
for DYDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DYDC1 gene
- DYDC22
1 SIMAP similar gene for DYDC1 using alignment to 2 protein entries: DYDC1_HUMAN (see all proteins):DYDC2
DYDC1 for paralogs About GeneDecksing
|
Genomic Variants
for DYDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DYDC1 (82095861 - 82116511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DYDC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DYDC1 |
|
Disorders
/ Diseases
for DYDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DYDC1 for disorders About GeneDecksing
4  diseases for DYDC1: About MalaCardsalzheimer's disease myofibrillar myopathy myopathy cardiomyopathy
Human Genome Epidemiology (HuGE) Navigator: DYDC1 (1 document)
Export disorders for DYDC1 gene to outside databases
|
Publications
for DYDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DYDC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DYDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis. (PubMed id 19545932)1, 2 Li S.... Wang L. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7: corroboration and narrowing of the critical region on 10q22.3. (PubMed id 18197198)1 Kuhl A....Jenne D.E. (2008)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for DYDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DYDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DYDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DYDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DYDC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DYDC1 gene:
Search GeneIP for patents involving DYDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DYDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DYDC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DYDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DYDC1 | | | OriGene Protein Over-expression Lysate for DYDC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DYDC1 | | OriGene 3'-UTR Clone for DYDC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DYDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DYDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DYDC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DYDC1 | | OriGene Custom Protein Services for DYDC1 | | | OriGene Custom Immunoassay Development | | |
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| | | | Search Tocris compounds for DYDC1 |
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 | | | DYDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for DYDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DYDC1 |
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