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Aliases for DXO Gene

Aliases for DXO Gene

  • Decapping Exoribonuclease 2 3
  • DOM3Z 3 4
  • DOM3L 3 4
  • NG6 3 4
  • DOM-3 (C. Elegans) Homolog Z 2
  • Dom-3 Homolog Z (C. Elegans) 2
  • Dom-3 Homolog Z 4
  • Protein Dom3Z 3
  • EC 3.1.13.- 4
  • EC 3.6.1.- 4
  • RAI1 3

External Ids for DXO Gene

Previous HGNC Symbols for DXO Gene

  • DOM3Z

Previous GeneCards Identifiers for DXO Gene

  • GC06M031950

Summaries for DXO Gene

Entrez Gene Summary for DXO Gene

  • This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DXO Gene

DXO (Decapping Exoribonuclease) is a Protein Coding gene. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression. GO annotations related to this gene include nucleotide binding and mRNA binding.

UniProtKB/Swiss-Prot for DXO Gene

  • Ribonuclease that specifically degrades pre-mRNAs with a defective 5 end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5-3 exonuclease activities. Has decapping activity toward incomplete 5 end cap mRNAs such as unmethylated 5 end-capped RNA to release GpppN and 5 end monophosphate RNA. The 5 end monophosphate RNA is then degraded by the 5-3 exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5-pyrophosphohydrolase activity by hydrolyzing the 5 end triphosphate to release pyrophosphates (By similarity).

Gene Wiki entry for DXO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DXO Gene

Genomics for DXO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DXO Gene

Chromosome:
6
Start:
31,969,810 bp from pter
End:
31,972,292 bp from pter
Size:
2,483 bases
Orientation:
Minus strand

Genomic View for DXO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DXO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for Regulatory Elements for DXO Gene

Proteins for DXO Gene

  • Protein details for DXO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O77932-DXO_HUMAN
    Recommended name:
    Decapping and exoribonuclease protein
    Protein Accession:
    O77932
    Secondary Accessions:
    • A2CER3
    • B0UZ80
    • O15004
    • O78127
    • O78128
    • Q5ST60
    • Q6IPZ2
    • Q9NPK4

    Protein attributes for DXO Gene

    Size:
    396 amino acids
    Molecular mass:
    44929 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB67983.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB89306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DXO Gene

Proteomics data for DXO Gene at MOPED

Post-translational modifications for DXO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DXO Gene

No data available for DME Specific Peptides for DXO Gene

Domains & Families for DXO Gene

Protein Domains for DXO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DXO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O77932

UniProtKB/Swiss-Prot:

DXO_HUMAN :
  • Belongs to the DXO/Dom3Z family.
Family:
  • Belongs to the DXO/Dom3Z family.
genes like me logo Genes that share domains with DXO: view

No data available for Gene Families for DXO Gene

Function for DXO Gene

Molecular function for DXO Gene

UniProtKB/Swiss-Prot Function:
Ribonuclease that specifically degrades pre-mRNAs with a defective 5 end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5-3 exonuclease activities. Has decapping activity toward incomplete 5 end cap mRNAs such as unmethylated 5 end-capped RNA to release GpppN and 5 end monophosphate RNA. The 5 end monophosphate RNA is then degraded by the 5-3 exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5-pyrophosphohydrolase activity by hydrolyzing the 5 end triphosphate to release pyrophosphates (By similarity).

Enzyme Numbers (IUBMB) for DXO Gene

Gene Ontology (GO) - Molecular Function for DXO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding ISS --
GO:0003729 mRNA binding ISS --
GO:0008409 5-3 exonuclease activity ISS --
GO:0034353 RNA pyrophosphohydrolase activity ISS --
genes like me logo Genes that share ontologies with DXO: view
genes like me logo Genes that share phenotypes with DXO: view

Animal Model Products

CRISPR Products

miRNA for DXO Gene

miRTarBase miRNAs that target DXO

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DXO Gene

Localization for DXO Gene

Subcellular locations from UniProtKB/Swiss-Prot for DXO Gene

Nucleus.

Gene Ontology (GO) - Cellular Components for DXO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with DXO: view

No data available for Subcellular locations from COMPARTMENTS for DXO Gene

Pathways & Interactions for DXO Gene

genes like me logo Genes that share pathways with DXO: view

Pathways by source for DXO Gene

1 Reactome pathway for DXO Gene

Gene Ontology (GO) - Biological Process for DXO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process ISS --
GO:0008152 metabolic process ISS --
GO:0050779 RNA destabilization ISS --
GO:0071028 nuclear mRNA surveillance ISS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis ISS --
genes like me logo Genes that share ontologies with DXO: view

No data available for SIGNOR curated interactions for DXO Gene

Drugs & Compounds for DXO Gene

No Compound Related Data Available

Transcripts for DXO Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DXO Gene

No ASD Table

Relevant External Links for DXO Gene

GeneLoc Exon Structure for
DXO
ECgene alternative splicing isoforms for
DXO

Expression for DXO Gene

mRNA expression in normal human tissues for DXO Gene

Protein differential expression in normal tissues from HIPED for DXO Gene

This gene is overexpressed in Testis (29.9), Peripheral blood mononuclear cells (21.0), NK cells (10.0), and Fetal ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DXO Gene



mRNA Expression by UniProt/SwissProt for DXO Gene

O77932-DXO_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with DXO: view

Protein tissue co-expression partners for DXO Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DXO Gene

Orthologs for DXO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DXO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOM3Z 35
  • 89.29 (n)
  • 92.24 (a)
DOM3Z 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DXO 35
  • 90.41 (n)
  • 91.99 (a)
DXO 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dxo 35
  • 86.7 (n)
  • 90.41 (a)
Dom3z 16
Dxo 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOM3Z 35
  • 99.33 (n)
  • 99.49 (a)
DXO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dxo 35
  • 87.56 (n)
  • 90.93 (a)
oppossum
(Monodelphis domestica)
Mammalia DXO 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DXO 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dxo 35
  • 56.14 (n)
  • 54.21 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:92781 35
  • 59.51 (n)
  • 53.17 (a)
DXO 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007205 35
  • 43.2 (n)
  • 31.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9125 35
  • 42.96 (n)
  • 28.27 (a)
CG9125 36
  • 26 (a)
OneToMany
cuff 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea math-43 35
  • 45.32 (n)
  • 33.09 (a)
dom-3 36
  • 26 (a)
OneToMany
math-43 36
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR263C 35
  • 45.05 (n)
  • 29.3 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12893g 35
  • 38.83 (n)
  • 27.72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAI1 35
  • 38.69 (n)
  • 28.57 (a)
RAI1 36
  • 21 (a)
OneToOne
RAI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17620 35
  • 42.24 (n)
  • 33.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04191 35
  • 48.7 (n)
  • 34.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes din1 35
  • 42.02 (n)
  • 33.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for DXO:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DXO Gene

ENSEMBL:
Gene Tree for DXO (if available)
TreeFam:
Gene Tree for DXO (if available)

Paralogs for DXO Gene

No data available for Paralogs for DXO Gene

Variants for DXO Gene

Sequence variations from dbSNP and Humsavar for DXO Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_027492 -
VAR_027493 -
VAR_027494 -
VAR_027495 -

Variation tolerance for DXO Gene

Residual Variation Intolerance Score: 79.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DXO Gene

HapMap Linkage Disequilibrium report
DXO
Human Gene Mutation Database (HGMD)
DXO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DXO Gene

Disorders for DXO Gene

Relevant External Links for DXO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DXO
genes like me logo Genes that share disorders with DXO: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DXO Gene

Publications for DXO Gene

  1. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. (PMID: 23523372) Jiao X. … Kiledjian M. (Mol. Cell 2013) 2 67
  2. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z- RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. (PMID: 9799600) Yang Z. … Yu C.Y. (Genomics 1998) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 67

Products for DXO Gene

Sources for DXO Gene

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