Aliases for DXO Gene
External Ids for DXO Gene
Previous HGNC Symbols for DXO Gene
Previous GeneCards Identifiers for DXO Gene
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DXO Gene
DXO (Decapping Exoribonuclease) is a Protein Coding gene. Diseases associated with DXO include Late-Onset Retinal Degenration and Gyrate Atrophy Of Choroid And Retina. Gene Ontology (GO) annotations related to this gene include nucleotide binding and mRNA binding.
UniProtKB/Swiss-Prot for DXO Gene
Ribonuclease that specifically degrades pre-mRNAs with a defective 5 end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5-3 exonuclease activities. Has decapping activity toward incomplete 5 end cap mRNAs such as unmethylated 5 end-capped RNA to release GpppN and 5 end monophosphate RNA. The 5 end monophosphate RNA is then degraded by the 5-3 exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5-pyrophosphohydrolase activity by hydrolyzing the 5 end triphosphate to release pyrophosphates (By similarity).