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Aliases for DXO Gene

Aliases for DXO Gene

  • Decapping Exoribonuclease 2 3 5
  • DOM3Z 3 4
  • DOM3L 3 4
  • NG6 3 4
  • Decapping And Exoribonuclease Protein 3
  • DOM-3 (C. Elegans) Homolog Z 2
  • Dom-3 Homolog Z (C. Elegans) 2
  • Dom-3 Homolog Z 4
  • Protein Dom3Z 3
  • EC 3.1.13.- 4
  • EC 3.6.1.- 4
  • RAI1 3

External Ids for DXO Gene

Previous HGNC Symbols for DXO Gene

  • DOM3Z

Previous GeneCards Identifiers for DXO Gene

  • GC06M031950

Summaries for DXO Gene

Entrez Gene Summary for DXO Gene

  • This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DXO Gene

DXO (Decapping Exoribonuclease) is a Protein Coding gene. Diseases associated with DXO include Gyrate Atrophy Of Choroid And Retina With Or Without Ornithinemia and Choroid Disease. GO annotations related to this gene include nucleotide binding and mRNA binding.

UniProtKB/Swiss-Prot for DXO Gene

  • Ribonuclease that specifically degrades pre-mRNAs with a defective 5 end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5-3 exonuclease activities. Has decapping activity toward incomplete 5 end cap mRNAs such as unmethylated 5 end-capped RNA to release GpppN and 5 end monophosphate RNA. The 5 end monophosphate RNA is then degraded by the 5-3 exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5-pyrophosphohydrolase activity by hydrolyzing the 5 end triphosphate to release pyrophosphates (By similarity).

Gene Wiki entry for DXO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DXO Gene

Genomics for DXO Gene

Regulatory Elements for DXO Gene

Enhancers for DXO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DXO on UCSC Golden Path with GeneCards custom track

Promoters for DXO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DXO Gene

Chromosome:
6
Start:
31,969,810 bp from pter
End:
31,972,292 bp from pter
Size:
2,483 bases
Orientation:
Minus strand

Genomic View for DXO Gene

Genes around DXO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DXO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DXO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DXO Gene

  • Protein details for DXO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O77932-DXO_HUMAN
    Recommended name:
    Decapping and exoribonuclease protein
    Protein Accession:
    O77932
    Secondary Accessions:
    • A2CER3
    • B0UZ80
    • O15004
    • O78127
    • O78128
    • Q5ST60
    • Q6IPZ2
    • Q9NPK4

    Protein attributes for DXO Gene

    Size:
    396 amino acids
    Molecular mass:
    44929 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB67983.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB89306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DXO Gene

Post-translational modifications for DXO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DXO Gene

No data available for DME Specific Peptides for DXO Gene

Domains & Families for DXO Gene

Protein Domains for DXO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DXO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O77932

UniProtKB/Swiss-Prot:

DXO_HUMAN :
  • Belongs to the DXO/Dom3Z family.
Family:
  • Belongs to the DXO/Dom3Z family.
genes like me logo Genes that share domains with DXO: view

No data available for Gene Families for DXO Gene

Function for DXO Gene

Molecular function for DXO Gene

UniProtKB/Swiss-Prot Function:
Ribonuclease that specifically degrades pre-mRNAs with a defective 5 end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5-3 exonuclease activities. Has decapping activity toward incomplete 5 end cap mRNAs such as unmethylated 5 end-capped RNA to release GpppN and 5 end monophosphate RNA. The 5 end monophosphate RNA is then degraded by the 5-3 exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5-pyrophosphohydrolase activity by hydrolyzing the 5 end triphosphate to release pyrophosphates (By similarity).

Enzyme Numbers (IUBMB) for DXO Gene

Gene Ontology (GO) - Molecular Function for DXO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding ISS --
GO:0003729 mRNA binding ISS --
GO:0008409 5-3 exonuclease activity ISS --
GO:0034353 RNA pyrophosphohydrolase activity ISS --
genes like me logo Genes that share ontologies with DXO: view
genes like me logo Genes that share phenotypes with DXO: view

Animal Model Products

CRISPR Products

miRNA for DXO Gene

miRTarBase miRNAs that target DXO

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DXO Gene

Localization for DXO Gene

Subcellular locations from UniProtKB/Swiss-Prot for DXO Gene

Nucleus.

Gene Ontology (GO) - Cellular Components for DXO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with DXO: view

No data available for Subcellular locations from COMPARTMENTS for DXO Gene

Pathways & Interactions for DXO Gene

SuperPathways for DXO Gene

No Data Available

Gene Ontology (GO) - Biological Process for DXO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process ISS --
GO:0008152 metabolic process ISS --
GO:0050779 RNA destabilization ISS --
GO:0071028 nuclear mRNA surveillance ISS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis ISS --
genes like me logo Genes that share ontologies with DXO: view

No data available for Pathways by source and SIGNOR curated interactions for DXO Gene

Drugs & Compounds for DXO Gene

No Compound Related Data Available

Transcripts for DXO Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DXO Gene

No ASD Table

Relevant External Links for DXO Gene

GeneLoc Exon Structure for
DXO
ECgene alternative splicing isoforms for
DXO

Expression for DXO Gene

mRNA expression in normal human tissues for DXO Gene

Protein differential expression in normal tissues from HIPED for DXO Gene

This gene is overexpressed in Testis (29.9), Peripheral blood mononuclear cells (21.0), NK cells (10.0), and Fetal ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DXO Gene



Protein tissue co-expression partners for DXO Gene

NURSA nuclear receptor signaling pathways regulating expression of DXO Gene:

DXO

mRNA Expression by UniProt/SwissProt for DXO Gene:

O77932-DXO_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with DXO: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DXO Gene

Orthologs for DXO Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DXO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOM3Z 34
  • 89.29 (n)
  • 92.24 (a)
DOM3Z 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DXO 34
  • 90.41 (n)
  • 91.99 (a)
DXO 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dxo 34
  • 86.7 (n)
  • 90.41 (a)
Dxo 16
Dxo 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dxo 34
  • 87.56 (n)
  • 90.93 (a)
oppossum
(Monodelphis domestica)
Mammalia DXO 35
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DXO 35
  • 99 (a)
OneToOne
DOM3Z 34
  • 99.33 (n)
  • 99.49 (a)
lizard
(Anolis carolinensis)
Reptilia DXO 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dxo 34
  • 56.14 (n)
  • 54.21 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:92781 34
  • 59.51 (n)
  • 53.17 (a)
DXO 35
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007205 34
  • 43.2 (n)
  • 31.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9125 34
  • 42.96 (n)
  • 28.27 (a)
CG9125 35
  • 26 (a)
OneToMany
cuff 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea math-43 34
  • 45.32 (n)
  • 33.09 (a)
dom-3 35
  • 26 (a)
OneToMany
math-43 35
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR263C 34
  • 45.05 (n)
  • 29.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAI1 34
  • 38.69 (n)
  • 28.57 (a)
RAI1 35
  • 21 (a)
OneToOne
RAI1 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12893g 34
  • 38.83 (n)
  • 27.72 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17620 34
  • 42.24 (n)
  • 33.22 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04191 34
  • 48.7 (n)
  • 34.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes din1 34
  • 42.02 (n)
  • 33.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for DXO was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DXO Gene

ENSEMBL:
Gene Tree for DXO (if available)
TreeFam:
Gene Tree for DXO (if available)

Paralogs for DXO Gene

No data available for Paralogs for DXO Gene

Variants for DXO Gene

Sequence variations from dbSNP and Humsavar for DXO Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_027492 -
VAR_027493 -
VAR_027494 -
VAR_027495 -

Structural Variations from Database of Genomic Variants (DGV) for DXO Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv284 CNV deletion 15895083
nsv428141 CNV gain+loss 18775914
nsv5247 CNV deletion 18451855
nsv601970 CNV loss 21841781
nsv601971 CNV gain 21841781
nsv830628 CNV loss 17160897

Variation tolerance for DXO Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DXO Gene

Human Gene Mutation Database (HGMD)
DXO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DXO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DXO Gene

Disorders for DXO Gene

MalaCards: The human disease database

(2) MalaCards diseases for DXO Gene - From: DISEASES

Disorder Aliases PubMed IDs
gyrate atrophy of choroid and retina with or without ornithinemia
  • gyrate atrophy of choroid and retina
choroid disease
  • choroid diseases
- elite association - COSMIC cancer census association via MalaCards
Search DXO in MalaCards View complete list of genes associated with diseases

Relevant External Links for DXO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DXO
genes like me logo Genes that share disorders with DXO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DXO Gene

Publications for DXO Gene

  1. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z- RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. (PMID: 9799600) Yang Z. … Yu C.Y. (Genomics 1998) 2 3 4 65
  2. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. (PMID: 23523372) Jiao X. … Kiledjian M. (Mol. Cell 2013) 2 3 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 65
  5. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4 65

Products for DXO Gene

Sources for DXO Gene

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