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DXO Gene

protein-coding   GIFtS: 39
GCID: GC06M031950

Decapping Exoribonuclease

(Previous names: DOM-3 (C. elegans) homolog Z, dom-3 homolog Z (C. elegans))
(Previous symbol: DOM3Z)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Decapping Exoribonuclease1 2     RAI12
DOM3Z1 2 3 5     Decapping And Exoribonuclease Protein2
DOM3L2 3     Protein Dom3Z2
NG62 3     EC 3.1.13.-3
DOM-3 (C. Elegans) Homolog Z1     EC 3.6.1.-3
Dom-3 Homolog Z (C. Elegans)1     Dom-3 Homolog Z3

External Ids:    HGNC: 29921   Entrez Gene: 17972   Ensembl: ENSG000002043487   OMIM: 6059965   UniProtKB: O779323   

Export aliases for DXO gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DXO Gene:
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function
of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex
eukaryotes suggests that this may be a housekeeping gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DXO Gene:
DXO (decapping exoribonuclease) is a protein-coding gene. Diseases associated with DXO include malaria, and alzheimer's disease. GO annotations related to this gene include mRNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: DXO_HUMAN, O77932
Function: Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA
capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping
activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end
monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling
this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity
by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity)

Gene Wiki entry for DXO (DOM3Z) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for DXO
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDXO promoter sequence
   Search Chromatin IP Primers for DXO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DXO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

DXO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DXO gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031950:  view genomic region     (about GC identifiers)

Start:
31,937,587 bp from pter      End:
31,940,069 bp from pter
Size:
2,483 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_113891.2 3,447,344-3,449,788      Chr6-,NT_167248 3,231,377-3,233,821      Chr6-,NT_167249 3,270,298-3,272,742     
Chr6-,NT_167245 3,223,171-3,225,615      Chr6-,NT_167247 3,317,432-3,319,876     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DXO_HUMAN, O77932 (See protein sequence)
Recommended Name: Decapping and exoribonuclease protein  
Size: 396 amino acids; 44929 Da
Cofactor: Binds 2 magnesium ions (By similarity)
Caution: In contrast to canonical decapping enzymes DCP2 and NUDT16, which release m(7)pppG (m(7)GDP), the
decapping activity releases the entire cap structure GpppN and a 5' end monophosphate RNA
Sequence caution: Sequence=AAB67983.1; Type=Erroneous gene model prediction; Sequence=CAB89306.1; Type=Erroneous
gene model prediction;
Secondary accessions: A2CER3 B0UZ80 O15004 O78127 O78128 Q5ST60 Q6IPZ2 Q9NPK4

Explore the universe of human proteins at neXtProt for DXO: NX_O77932

Explore proteomics data for DXO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DXO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005501.2  
    ENSEMBL proteins: 
     ENSP00000337759   ENSP00000364498   ENSP00000419588   ENSP00000364505   ENSP00000418632  

    DXO Human Recombinant Protein Products:

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    Novus Biologicals DXO Protein
    Novus Biologicals DXO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    DXO Antibody Products:

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    OriGene Custom Antibody Services for DXO
    Novus Biologicals DXO Antibodies
    Search for Antibodies for DXO at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for DXO
    LSBio Antibodies in human, mouse, rat for DXO

    DXO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DXO
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013961 RAI1

    Graphical View of Domain Structure for InterPro Entry O77932

    ProtoNet protein and cluster: O77932

    1 Blocks protein domain: IPB013961 RAI1 like

    UniProtKB/Swiss-Prot: DXO_HUMAN, O77932
    Similarity: Belongs to the DXO/Dom3Z family


    DXO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DXO_HUMAN, O77932
    Function: Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA
    capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping
    activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end
    monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling
    this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity
    by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.13.-1 EC 3.6.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0000287magnesium ion binding ISS--
    GO:0003729mRNA binding ISS--
    GO:00084095'-3' exonuclease activity ISS--
    GO:0034353RNA pyrophosphohydrolase activity ISS--
         
    DXO for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DXO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DXO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DXO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DXO

    miRNA
    Products:
        
    miRTarBase miRNAs that target DXO:
    hsa-mir-615-3p (MIRT040304)

    Block miRNA regulation of human, mouse, rat DXO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DXO
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DXO

    Gene Editing
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    GenScript Custom all cDNA clones Services for DXO
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DXO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DXO

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DXO 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DXO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DXO_HUMAN, O77932: Nucleus

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DXO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DXO
    Interactions:

        Search GeneGlobe Interaction Network for DXO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DXO (O779322, 3 ENSP000003377594) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLOT2Q142542, 3, ENSP000003783684MINT-62761 MINT-62587 MINT-62685 I2D: score=4 STRING: ENSP00000378368
    EXOSC7Q150243, ENSP000002655644I2D: score=3 STRING: ENSP00000265564
    UPF1Q929003, ENSP000002628034I2D: score=2 STRING: ENSP00000262803
    XRN1Q8IZH23, ENSP000002649514I2D: score=2 STRING: ENSP00000264951
    XRN2Q9H0D63, ENSP000003663964I2D: score=4 STRING: ENSP00000366396
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402mRNA catabolic process ISS--
    GO:0008152metabolic process ISS--
    GO:0050779RNA destabilization ISS--
    GO:0071028nuclear mRNA surveillance ISS--
    GO:0090305nucleic acid phosphodiester bond hydrolysis ISS--

    DXO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DXO



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DXO gene: 
    NM_005510.3  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491327 ENST00000485557 ENST00000477826 ENST00000337523(uc003nyp.1 uc003nyq.1)
    ENST00000375349(uc003nyu.1) ENST00000495340 ENST00000473976 ENST00000478221
    ENST00000375356 ENST00000498357 ENST00000480240 ENST00000474587 ENST00000492946(uc010jtl.1)
    ENST00000487914 ENST00000460058
    miRNA
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    Block miRNA regulation of human, mouse, rat DXO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DXO
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DXO
    Predesigned siRNA for gene silencing in human, mouse, rat DXO
    Clone
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    OriGene clones in human, mouse for DXO (see all 9)
    OriGene ORF clones in mouse, rat for DXO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for DXO
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DXO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DXO
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DXO
    OriGene qSTAR qPCR primer pairs in human, mouse for DXO
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DXO
      QuantiTect SYBR Green Assays in human, mouse, rat DXO
      QuantiFast Probe-based Assays in human, mouse, rat DXO

    Selected AceView cDNA sequences (see all 144):

    NM_005510 CR622082 BC058885 BM922282 CR590730 BC009344 BM701096 BC019083 
    F08347 CR596930 AL542827 AF059252 Z41353 BP873226 AI400743 CB154762 
    CR602638 AA004835 AI208763 CD518827 BU687914 CR622492 BC071651 BI334166 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    DXO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DXO Protein Expression

    UniProtKB/Swiss-Prot: DXO_HUMAN, O77932
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for DXO
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    QuantiFast Probe-based Assays in human, mouse, rat DXO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DXO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DXO gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dom3z5
    Dxo1
    DOM-3 homolog Z (C. elegans)5
    decapping exoribonuclease1
    86.7(n)1
    90.41(a)1
      17 (18.39 cM)5
    1124031  NM_001163770.11  NP_001157242.11 
     348370195 
    lizard
    (Anolis carolinensis)
    Reptilia DXO6
    decapping exoribonuclease
    58(a)
    1 ↔ 1
    2(194143488-194156730)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dxo1 decapping exoribonuclease 56.14(n)
    54.21(a)
      549142  NM_001016388.2  NP_001016388.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:927811 zgc:92781 59.51(n)
    53.17(a)
      494170  NM_001009906.1  NP_001009906.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91251 CG9125 42.96(n)
    28.27(a)
      2768882  NM_206769.3  NP_996492.1 
    worm
    (Caenorhabditis elegans)
    Secernentea math-431 math-43 45.32(n)
    33.09(a)
      353489  NM_182463.1  NP_872263.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAI1(YGL246C)4
    RAI11
    Nuclear protein with decapping endonuclease activity more4
    RAI11
    38.69(n)1
    28.57(a)1
      7(38780-37617)4
    8526461, 4  NP_011268.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G176201 AT4G17620 42.24(n)
    33.22(a)
      827482  NM_117871.4  NP_193498.2 


    ENSEMBL Gene Tree for DXO (if available)
    TreeFam Gene Tree for DXO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for DXO    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122051381,2,4
    ----see VAR_0274952 mis40--------
    rs10566941,2,4
    ----see VAR_0274922 mis40--------
    rs27463961,2,4
    ----see VAR_0274932 mis40--------
    rs172078671,2,4
    ----see VAR_0274942 mis40--------

    HapMap Linkage Disequilibrium report for DXO (31937587 - 31940069 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DXO: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DXO
    DNA2.0 Custom Variant and Variant Library Synthesis for DXO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605996    OMIM disorders: --

    2 diseases for DXO:    
    About MalaCards
    malaria    alzheimer's disease


    DXO for disorders           About GeneDecksing


    Export disorders for DXO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DXO gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with DXO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z- RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. (PubMed id 9799600)1, 2, 3 Yang Z.... Yu C.Y. (Genomics 1998)
    2. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. (PubMed id 23523372)1, 3 Jiao X....Kiledjian M. (Mol. Cell 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    6. Organizations and gene duplications of the human and mouse MHC complement gene clusters. (PubMed id 10686478)1, 2 Yang Z. and Yu C.Y. (Exp. Clin. Immunogenet. 2000)
    7. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    8. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PubMed id 23263863)1 Li J....Sleiman P.M. (Hum. Mol. Genet. 2013)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation. (PubMed id 21750099)2 Zheng D.... Shyu A.B. (RNA 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1797 HGNC: 2992 AceView: DOM3Z Ensembl:ENSG00000204348 euGenes: HUgn1797
    ECgene: DXO H-InvDB: DXO

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DXO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DXO gene:
    Search GeneIP for patents involving DXO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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