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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DVL3 Gene

protein-coding   GIFtS: 67
GCID: GC03P183873

Dishevelled Segment Polarity Protein 3

(Previous names: dishevelled 3 (homologous to Drosophila dsh), dishevelled,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dishevelled Segment Polarity Protein 31 2     dishevelled-32
Dishevelled 3 (Homologous To Drosophila Dsh)1 2     Segment Polarity Protein Dishevelled Homolog DVL-32
DSH Homolog 32 3     Dishevelled-33
Dishevelled, Dsh Homolog 3 (Drosophila)1     KIAA02083
Dishevelled, Dsh Homolog 32     

External Ids:    HGNC: 30871   Entrez Gene: 18572   Ensembl: ENSG000001612027   OMIM: 6013685   UniProtKB: Q929973   

Export aliases for DVL3 gene to outside databases

Previous GC identifers: GC03M180749 GC03P184867 GC03P185275 GC03P185194 GC03P185357 GC03P185358 GC03P185360 GC03P181280


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DVL3 Gene:
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene,
dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DVL3 Gene: 
DVL3 (dishevelled segment polarity protein 3) is a protein-coding gene. Diseases associated with DVL3 include birth defects, and fetal alcohol syndrome, and among its related super-pathways are Wnt signaling pathway and Notch Signaling Pathway. GO annotations related to this gene include protein heterodimerization activity and signal transducer activity. An important paralog of this gene is DVL1.

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997
Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Gene Wiki entry for DVL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DVL3 gene promoter:
         TBP   MyoD   Arnt   YY1   CREB   HEN1   FAC1   POU2F1   Ik-2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDVL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DVL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DVL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27

DVL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P183873:  view genomic region     (about GC identifiers)

Start:
183,873,176 bp from pter      End:
183,891,398 bp from pter
Size:
18,223 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997 (See protein sequence)
Recommended Name: Segment polarity protein dishevelled homolog DVL-3  
Size: 716 amino acids; 78055 Da
Subunit: Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity).
Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this
interaction. Interacts with CYLD, CEP164 and DAB2
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA13199.2; Type=Erroneous initiation;
Secondary accessions: D3DNT0 O14642 Q13531 Q8N5E9 Q92607

Explore the universe of human proteins at neXtProt for DVL3: NX_Q92997

Explore proteomics data for DVL3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains
  • UniProtKB: Phosphorylated by CSNK1D
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92997

  • DVL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DVL3 Protein Expression
    REFSEQ proteins: NP_004414.3  
    ENSEMBL proteins: 
     ENSP00000316054   ENSP00000412345   ENSP00000405885   ENSP00000393849  

    Human Recombinant Protein Products for DVL3: 
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    Novus Biologicals DVL3 Proteins
    Novus Biologicals DVL3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DVL3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005938cell cortex IBA--

    DVL3 for ontologies           About GeneDecksing



    DVL3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL3
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    Cloud-Clone Corp. ELISAs for DVL3 
    Cloud-Clone Corp. CLIAs for DVL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DVL: Dishevelled homologs

    5/9 InterPro protein domains (see all 9):
     IPR011991 WHTH_DNA-bd_dom
     IPR001478 PDZ
     IPR024580 Dishevelled_C-dom
     IPR008342 Dishevelled_3
     IPR015506 Dsh/Dvl-rel

    Graphical View of Domain Structure for InterPro Entry Q92997

    ProtoNet protein and cluster: Q92997

    4 Blocks protein domains:
    IPB000591 Pleckstrin putative G-protein interacting domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB003351 Dishevelled protein
    IPB008339 Dishevelled protein signature


    UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997
    Similarity: Belongs to the DSH family
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 DIX domain
    Similarity: Contains 1 PDZ (DHR) domain


    DVL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DVL3_HUMAN, Q92997
    Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

         Genatlas biochemistry entry for DVL3:
    Drosophila dishevelled segment polarity gene homolog 3,widely expressed,putatively involved in neural and heart
    development,activated in WNT signal transduction

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI--
    GO:0004871signal transducer activity IEA--
    GO:0005102receptor binding IPI17030191
    GO:0005109frizzled binding IPI19388021
    GO:0005515protein binding IPI10330181
         
    DVL3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for DVL3:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased Salmonella enterica   Increased cell number in G2M,  
     Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dvl3):
     cardiovascular system  craniofacial  embryogenesis  growth/size  hearing/vestibular/ear 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton 

    DVL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dvl3tm1Awb for DVL3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DVL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DVL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DVL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DVL3 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDVL3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DVL3 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Notch signaling pathway
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    3Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor0.49
    Transcription Androgen Receptor nuclear signaling0.49
    5Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DVL3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for DVL3
        Wnt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for DVL3
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for DVL3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/9 BioSystems Pathways for DVL3 (see all 9)
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Notch Signaling Pathway
    Neural Crest Differentiation


    5/7         Kegg Pathways  (Kegg details for DVL3) (see all 7):
        Wnt signaling pathway
    Notch signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    DVL3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DVL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/209 Interacting proteins for DVL3 (Q929971, 2, 3 ENSP000003160544) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151692, 3, ENSP000002623204MINT-8284998 MINT-8277609 I2D: score=4 STRING: ENSP00000262320
    PPM1AP358132, 3, ENSP000003272554MINT-8284998 MINT-8277609 I2D: score=3 STRING: ENSP00000327255
    WT1P195442, 3, ENSP000003313274MINT-8277130 I2D: score=3 STRING: ENSP00000331327
    PIK3CBP423382, 3, ENSP000002891534MINT-8266161 I2D: score=2 STRING: ENSP00000289153
    LRRFIP2Q9Y6081, 3, ENSP000003387274EBI-739789,EBI-1023718 I2D: score=1 STRING: ENSP00000338727
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0003007heart morphogenesis ----
    GO:0003148outflow tract septum morphogenesis IBA--
    GO:0007275multicellular organismal development ----
    GO:0016055Wnt receptor signaling pathway IDA10644691

    DVL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DVL3

    Search CenterWatch for drugs/clinical trials and news about DVL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DVL3 gene: 
    NM_004423.3  

    Unigene Cluster for DVL3:

    Dishevelled, dsh homolog 3 (Drosophila)
    Hs.388116  [show with all ESTs]
    Unigene Representative Sequence: D86963
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313143(uc003fms.3 uc011bqw.2 uc003fmt.3 uc003fmu.3)
    ENST00000435708 ENST00000431765 ENST00000462665 ENST00000423300 ENST00000478247
    ENST00000467873 ENST00000478639
    miRNA
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    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL3 (see all 65):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-548a-5p hsa-miR-4293 hsa-miR-193b hsa-miR-4324 hsa-miR-647 hsa-miR-559
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL3

    Additional mRNA sequence: 

    AF006013.1 AK093469.1 AK304686.1 AL110278.1 BC018289.1 BC032459.1 D86963.1 U48252.1 
    U49262.1 U75651.1 

    19 DOTS entries:

    DT.315588  DT.315589  DT.100751578  DT.100037368  DT.97861544  DT.95090999  DT.91905805  DT.95269593 
    DT.95269607  DT.100037366  DT.120901374  DT.91758519  DT.92033526  DT.120654  DT.92001890  DT.95269549 
    DT.100752261  DT.95146251  DT.95269597 

    24/324 AceView cDNA sequences (see all 324):

    CA412354 AI270784 AX748146 AI400512 CF135806 AI239718 AK093469 BU608806 
    AI936622 BM689582 BM850440 BQ187303 BU736504 BU195638 BQ689957 BM661559 
    AI571296 BG762920 CK725210 BC032459 BU848828 AI831498 R80505 AI263385 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DVL3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:              -     -     -                             -                             -                                                                     
    SP2:                          -                             -                             -                             -     -                                 
    SP3:                                                                                                                                                            
    SP4:                    -     -                                                                                                                                 
    SP5:              -     -     -                                                                                                                                 

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DVL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DVL3 expression in normal human tissues (normalized intensities)      DVL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAACCCCA
    DVL3 Expression
    About this image


    DVL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             atrial myocardium   
     
     Breast (Uncategorized)
             breast epithelium   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Epithelium
             breast epithelium   
     
     Thyroid (Endocrine System)

    See DVL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DVL3

    SOURCE GeneReport for Unigene cluster: Hs.388116
        SABiosciences Expression via Pathway-Focused PCR Array including DVL3: 
              Neurogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DVL3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dvl31 , 5 dishevelled 3, dsh homolog (Drosophila)1, 5 90.78(n)1
    99.02(a)1
      16 (12.46 cM)5
    135441  NM_007889.21  NP_031915.21 
     205169825 
    chicken
    (Gallus gallus)
    Aves DVL31 dishevelled, dsh homolog 3 (Drosophila) 82.86(n)
    91.33(a)
      424949  XM_422756.3  XP_422756.3 
    lizard
    (Anolis carolinensis)
    Reptilia DVL36
    dishevelled, dsh homolog 3 (Drosophila)
    83(a)
    1 ↔ 1
    GL343245.1(1590000-1638462)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68922 Transcribed sequence with moderate similarity to protein more 78.22(n)    AL958553.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001490821 segment polarity protein dishevelled homolog DVL-3-like 73.17(n)
    81.07(a)
      100149082  XM_001920207.3  XP_001920242.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta dsh1 , 3 cell motility Notch binding3
    dishevelled1
    54(a)3
    56.36(n)1
    52.9(a)1
      320781  NM_078563.31  NP_511118.21 
    worm
    (Caenorhabditis elegans)
    Secernentea dsh-16
    mig-56
    (see all 3)
    Protein MIG-5, isoform a
    (see all 3)
    21(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(5214441-5225373)
    II(8182321-8185023)


    ENSEMBL Gene Tree for DVL3 (if available)
    TreeFam Gene Tree for DVL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DVL3 gene
    DVL12  DVL22  DIXDC12  
    5 SIMAP similar genes for DVL3 using alignment to 5 protein entries:     DVL3_HUMAN (see all proteins):
    DKFZp586M1622    DVL2    DVL1P1    DVL1    DLG4

    DVL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/639 SNPs in DVL3 are shown (see all 639)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361164
    A breast cancer sample4--see VAR_0361162 R T mis40--------
    rs1112377861,2
    F--183729594(+) GAGGTC/TCCAAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs759526401,2
    C,F--183729610(+) AGGAAG/AGCCAT 1 -- int12Minor allele frequency- A:0.10WA EA 238
    rs8445401,2
    C,F,O,A,H--183729766(-) TCAGTT/AACTAG 1 -- int127Minor allele frequency- A:0.34NA NS EA WA 2688
    rs29326581,2
    H--183729907(-) cAGAAT/GTGTTG 1 -- int13Minor allele frequency- G:0.00EA NS 300
    rs778355151,2
    C,F--183729917(+) GGCCGC/TGTGCA 1 -- int11Minor allele frequency- T:0.09WA 118
    rs8433621,2
    C,F,A--183729982(-) TCTTCG/ACCTCA 1 -- int111Minor allele frequency- A:0.44NA WA CSA EA 373
    rs1878441191,2
    --183729991(+) GAGTTC/TGAGAC 1 -- int10--------
    rs1912079341,2
    --183730098(+) GAGAAC/TTGCTT 1 -- int10--------
    rs1432493251,2
    --183730227(+) TTAAAC/TGGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DVL3 (183873176 - 183891398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for DVL3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671751CNV Deletion23128226
    esv2514927CNV Deletion19546169
    esv1000394CNV Deletion20482838
    esv2726295CNV Deletion23290073
    esv1004549CNV Deletion20482838
    nsv513096CNV Loss21212237
    nsv878056CNV Loss21882294
    esv8912CNV Loss19470904
    nsv829812CNV Loss17160897
    nsv878057CNV Loss21882294


    Human Gene Mutation Database (HGMD): DVL3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DVL3
    DNA2.0 Custom Variant and Variant Library Synthesis for DVL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601368    OMIM disorders: --

    12 diseases for DVL3:    About MalaCards
    birth defects    fetal alcohol syndrome    alcohol-related birth defect    partial fetal alcohol syndrome
    synovial sarcoma    neural tube defects    basal cell carcinoma    alcoholism
    malignant pleural mesothelioma    major depressive disorder    sarcoma    lung cancer


    DVL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DVL3

    Export disorders for DVL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DVL3 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with DVL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)1, 2, 3 Pizzuti A.... Dallapiccola B. (1996)
    2. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. (PubMed id 9344861)1, 2, 9 Bui T.D.... Harris A.L. (1997)
    3. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PubMed id 22863007)1, 2 Chaki M....Hildebrandt F. (2012)
    4. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1, 4 (2012)
    5. Delicate analysis of post-translational modifications on Dishevelled 3. (PubMed id 22612246)1, 2 Wu C.... Zeng R. (2012)
    6. Loss of the tumor suppressor CYLD enhances Wnt/beta-c atenin signaling through K63-linked ubiquitination of Dvl. (PubMed id 20227366)1, 2 Tauriello D.V....Maurice M.M. (2010)
    7. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. (PubMed id 15677333)1, 2 Liu J....Schultz P.G. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Regulation of the Wnt signaling pathway by disabled-2 (Dab2). (PubMed id 12805222)1, 2 Hocevar B.A....Howe P.H. (2003)
    10. Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)1, 2 Semenov M.V. and Snyder M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1857 HGNC: 3087 AceView: DVL3 Ensembl:ENSG00000161202 euGenes: HUgn1857
    ECgene: DVL3 Kegg: 1857 H-InvDB: DVL3

    (According to HUGE)
    About This Section
    HUGE: KIAA0208

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DVL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DVL3 gene:
    Search GeneIP for patents involving DVL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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