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DVL3 Gene

protein-coding   GIFtS: 69
GCID: GC03P183873

Dishevelled Segment Polarity Protein 3

(Previous names: dishevelled 3 (homologous to Drosophila dsh), dishevelled,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dishevelled Segment Polarity Protein 31 2     dishevelled-32
Dishevelled 3 (Homologous To Drosophila Dsh)1 2     Segment Polarity Protein Dishevelled Homolog DVL-32
DSH Homolog 32 3     Dishevelled-33
Dishevelled, Dsh Homolog 3 (Drosophila)1     KIAA02083
Dishevelled, Dsh Homolog 32     

External Ids:    HGNC: 30871   Entrez Gene: 18572   Ensembl: ENSG000001612027   OMIM: 6013685   UniProtKB: Q929973   

Export aliases for DVL3 gene to outside databases

Previous GC identifers: GC03M180749 GC03P184867 GC03P185275 GC03P185194 GC03P185357 GC03P185358 GC03P185360 GC03P181280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DVL3 Gene:
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene,
dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DVL3 Gene:
DVL3 (dishevelled segment polarity protein 3) is a protein-coding gene. Diseases associated with DVL3 include alcohol-related birth defect, and partial fetal alcohol syndrome. GO annotations related to this gene include protein heterodimerization activity and signal transducer activity. An important paralog of this gene is DVL1.

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997
Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Gene Wiki entry for DVL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DVL3 gene promoter:
         TBP   MyoD   Arnt   YY1   CREB   HEN1   FAC1   POU2F1   Ik-2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDVL3 promoter sequence
   Search Chromatin IP Primers for DVL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DVL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27

DVL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P183873:  view genomic region     (about GC identifiers)

Start:
183,873,176 bp from pter      End:
183,891,398 bp from pter
Size:
18,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997 (See protein sequence)
Recommended Name: Segment polarity protein dishevelled homolog DVL-3  
Size: 716 amino acids; 78055 Da
Subunit: Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity).
Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this
interaction. Interacts with CYLD, CEP164 and DAB2
Sequence caution: Sequence=BAA13199.2; Type=Erroneous initiation;
Secondary accessions: B4E3E5 D3DNT0 O14642 Q13531 Q8N5E9 Q92607
Alternative splicing: 2 isoforms:  Q92997-1   Q92997-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DVL3: NX_Q92997

Explore proteomics data for DVL3 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains1
  • Phosphorylated by CSNK1D1
  • Arginine methylation may function as a switch in regulation of function in Wnt signaling1
  • Ubiquitination2 at Lys283
  • Modification sites at PhosphoSitePlus

  • See DVL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004414.3  
    ENSEMBL proteins: 
     ENSP00000316054   ENSP00000412345   ENSP00000405885   ENSP00000393849  
    Reactome Protein details: Q92997

    DVL3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals DVL3 Proteins
    Novus Biologicals DVL3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DVL3

    DVL3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL3
    R&D Systems Antibodies for DVL3 (Dishevelled-3)
    Cell Signaling Technology (CST) Antibodies for DVL3 
    OriGene Antibodies for DVL3
    OriGene Custom Antibody Services for DVL3
    Novus Biologicals DVL3 Antibodies
    Abcam antibodies for DVL3
    Cloud-Clone Corp. Antibodies for DVL3
    ThermoFisher Antibody for DVL3
    LSBio Antibodies in human, mouse, rat for DVL3

    DVL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DVL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DVL3
    Cloud-Clone Corp. CLIAs for DVL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DVL: Dishevelled homologs

    Selected InterPro protein domains (see all 9):
     IPR011991 WHTH_DNA-bd_dom
     IPR001478 PDZ
     IPR024580 Dishevelled_C-dom
     IPR008342 Dishevelled_3
     IPR015506 Dsh/Dvl-rel

    Graphical View of Domain Structure for InterPro Entry Q92997

    ProtoNet protein and cluster: Q92997

    4 Blocks protein domains:
    IPB000591 Pleckstrin putative G-protein interacting domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB003351 Dishevelled protein
    IPB008339 Dishevelled protein signature


    UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997
    Similarity: Belongs to the DSH family
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 DIX domain
    Similarity: Contains 1 PDZ (DHR) domain


    DVL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DVL3_HUMAN, Q92997
    Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

         Genatlas biochemistry entry for DVL3:
    Drosophila dishevelled segment polarity gene homolog 3,widely expressed,putatively involved in neural and heart
    development,activated in WNT signal transduction

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI--
    GO:0004871signal transducer activity IEA--
    GO:0005102receptor binding IPI17030191
    GO:0005109frizzled binding IPI19388021
    GO:0005515protein binding IPI10330181
         
    DVL3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for DVL3:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased Salmonella enterica   Increased cell number in G2M,  
     Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dvl3):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton 

    DVL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dvl3tm1Awb for DVL3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DVL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DVL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DVL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DVL3

    miRNA
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    miRTarBase miRNAs that target DVL3:
    hsa-mir-320a (MIRT044424), hsa-mir-615-3p (MIRT039825), hsa-mir-17-3p (MIRT050752), hsa-mir-26b-5p (MIRT030326), hsa-mir-93-5p (MIRT048809)

    Block miRNA regulation of human, mouse, rat DVL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DVL3 (see all 65):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-548a-5p hsa-miR-4293 hsa-miR-193b hsa-miR-4324 hsa-miR-647 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidDVL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DVL3
    Predesigned siRNA for gene silencing in human, mouse, rat DVL3

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for DVL3 (see all 6)
    OriGene ORF clones in mouse, rat for DVL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DVL3 (NM_004423)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DVL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DVL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DVL3_HUMAN, Q92997: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005938cell cortex IBA--

    DVL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DVL3 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79
    5Transcription Androgen Receptor nuclear signaling
    Transcription Androgen Receptor nuclear signaling0.49
    Translation Non genomic rapid action of Androgen Receptor0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DVL3
        Wnt Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for DVL3
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for DVL3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for DVL3 (see all 9)
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Notch Signaling Pathway
    Neural Crest Differentiation

    5 Reactome Pathways for DVL3
        degradation of DVL
    WNT mediated activation of DVL
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    PCP/CE pathway
    TCF dependent signaling in response to WNT


    Selected Kegg Pathways  (Kegg details for DVL3) (see all 7):
        Wnt signaling pathway
    Notch signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    DVL3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DVL3: 
              Neurogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DVL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DVL3 (Q929971, 2, 3 ENSP000003160544) via UniProtKB, MINT, STRING, and/or I2D (see all 359)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151692, 3, ENSP000002623204MINT-8284998 MINT-8277609 I2D: score=4 STRING: ENSP00000262320
    PPM1AP358132, 3, ENSP000003272554MINT-8284998 MINT-8277609 I2D: score=3 STRING: ENSP00000327255
    PRPF3O433951, 3, ENSP000003153794EBI-739789,EBI-744322 I2D: score=5 STRING: ENSP00000315379
    WT1P195442, 3, ENSP000003313274MINT-8277130 I2D: score=3 STRING: ENSP00000331327
    LRRFIP2Q9Y6081, 3, ENSP000003387274EBI-739789,EBI-1023718 I2D: score=1 STRING: ENSP00000338727
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0003007heart morphogenesis ----
    GO:0003148outflow tract septum morphogenesis IBA--
    GO:0007275multicellular organismal development ----
    GO:0016055Wnt signaling pathway IDA10644691

    DVL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DVL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DVL3 gene: 
    NM_004423.3  

    Unigene Cluster for DVL3:

    Dishevelled, dsh homolog 3 (Drosophila)
    Hs.388116  [show with all ESTs]
    Unigene Representative Sequence: D86963
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313143(uc003fms.3 uc011bqw.2 uc003fmt.3 uc003fmu.3)
    ENST00000435708 ENST00000431765 ENST00000462665 ENST00000423300 ENST00000478247
    ENST00000467873 ENST00000478639
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DVL3 (see all 65):
    hsa-miR-548j hsa-miR-193a-3p hsa-miR-548a-5p hsa-miR-4293 hsa-miR-193b hsa-miR-4324 hsa-miR-647 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidDVL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DVL3
    Clone
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    OriGene ORF clones in mouse, rat for DVL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DVL3 (NM_004423)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL3
    Primer
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    OriGene qPCR primer pairs and template standards for DVL3
    OriGene qSTAR qPCR primer pairs in human, mouse for DVL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DVL3
      QuantiTect SYBR Green Assays in human, mouse, rat DVL3
      QuantiFast Probe-based Assays in human, mouse, rat DVL3

    Additional mRNA sequence: 

    AF006013.1 AK093469.1 AK304686.1 AL110278.1 BC018289.1 BC032459.1 D86963.1 U48252.1 
    U49262.1 U75651.1 

    19 DOTS entries:

    DT.315588  DT.315589  DT.100751578  DT.100037368  DT.97861544  DT.95090999  DT.91905805  DT.95269593 
    DT.95269607  DT.100037366  DT.120901374  DT.91758519  DT.92033526  DT.120654  DT.92001890  DT.95269549 
    DT.100752261  DT.95146251  DT.95269597 

    Selected AceView cDNA sequences (see all 324):

    BM918102 AI270784 AI240261 CA438588 D86963 AA044175 AK093469 BG762920 
    AI263385 BM726300 CK822981 AI239718 BQ689957 BU848828 BU608000 BU608806 
    BU146077 CD674170 BU195638 AX748146 CA310212 BC018289 NM_004423 AI831498 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DVL3 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:              -     -     -                             -                             -                                                                     
    SP2:                          -                             -                             -                             -     -                                 
    SP3:                                                                                                                                                            
    SP4:                    -     -                                                                                                                                 
    SP5:              -     -     -                                                                                                                                 

    ExUns: 19a · 19b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DVL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DVL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAACCCCA
    DVL3 Expression
    About this image


    DVL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Metencephalon
    DVL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DVL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388116
        Pathway & Disease-focused RT2 Profiler PCR Array including DVL3: 
              Neurogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DVL3
    OriGene qSTAR qPCR primer pairs in human, mouse for DVL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DVL3
    QuantiTect SYBR Green Assays in human, mouse, rat DVL3
    QuantiFast Probe-based Assays in human, mouse, rat DVL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DVL3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dvl31 , 5 dishevelled 3, dsh homolog (Drosophila)1, 5 90.78(n)1
    99.02(a)1
      16 (12.46 cM)5
    135441  NM_007889.21  NP_031915.21 
     205169825 
    chicken
    (Gallus gallus)
    Aves DVL31 dishevelled, dsh homolog 3 (Drosophila) 82.46(n)
    91.12(a)
      424949  XM_004943396.1  XP_004943453.1 
    lizard
    (Anolis carolinensis)
    Reptilia DVL36
    dishevelled segment polarity protein 3
    83(a)
    1 ↔ 1
    GL343245.1(1590000-1638462)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.68922 Transcribed sequence with moderate similarity to protein more 78.22(n)    AL958553.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001490821 segment polarity protein dishevelled homolog DVL-3-like 70.65(n)
    76.98(a)
      100149082  XM_001920207.4  XP_001920242.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta dsh1 , 3 cell motility Notch binding3
    dishevelled1
    54(a)3
    58.84(n)1
    56.53(a)1
      320781  NM_078563.31  NP_511118.21 
    worm
    (Caenorhabditis elegans)
    Secernentea dsh-26
    mig-56
    (see all 3)
    Protein MIG-5, isoform a
    (see all 3)
    29(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(5078210-5081161) WBGene00001102
    II(8182323-8185023) WBGene00003241


    ENSEMBL Gene Tree for DVL3 (if available)
    TreeFam Gene Tree for DVL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DVL3 gene
    DVL12  DVL22  DIXDC12  
    5 SIMAP similar genes for DVL3 using alignment to 4 protein entries:     DVL3_HUMAN (see all proteins):
    DKFZp586M1622    DVL2    DVL1P1    DVL1    DLG4

    DVL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DVL3 (see all 639)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361164
    A breast cancer sample4--see VAR_0361162 R T mis40--------
    rs1112377861,2
    F--183729594(+) GAGGTC/TCCAAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs759526401,2
    C,F--183729610(+) AGGAAG/AGCCAT 1 -- int12Minor allele frequency- A:0.10WA EA 238
    rs8445401,2
    C,F,O,A,H--183729766(-) TCAGTT/AACTAG 1 -- int127Minor allele frequency- A:0.34NA NS EA WA 2688
    rs29326581,2
    H--183729907(-) cAGAAT/GTGTTG 1 -- int13Minor allele frequency- G:0.00EA NS 300
    rs778355151,2
    C,F--183729917(+) GGCCGC/TGTGCA 1 -- int11Minor allele frequency- T:0.09WA 118
    rs8433621,2
    C,F,A--183729982(-) TCTTCG/ACCTCA 1 -- int111Minor allele frequency- A:0.44NA WA CSA EA 373
    rs1878441191,2
    --183729991(+) GAGTTC/TGAGAC 1 -- int10--------
    rs1912079341,2
    --183730098(+) GAGAAC/TTGCTT 1 -- int10--------
    rs1432493251,2
    --183730227(+) TTAAAC/TGGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DVL3 (183873176 - 183891398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DVL3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671751CNV Deletion23128226
    esv2514927CNV Deletion19546169
    esv1000394CNV Deletion20482838
    esv2726295CNV Deletion23290073
    esv1004549CNV Deletion20482838
    nsv513096CNV Loss21212237
    nsv878056CNV Loss21882294
    esv8912CNV Loss19470904
    nsv829812CNV Loss17160897
    nsv878057CNV Loss21882294

    Human Gene Mutation Database (HGMD): DVL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DVL3
    DNA2.0 Custom Variant and Variant Library Synthesis for DVL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601368    OMIM disorders: --

    19 diseases for DVL3:    
    About MalaCards
    alcohol-related birth defect    partial fetal alcohol syndrome    fetal alcohol syndrome    malignant pleural mesothelioma
    alk-positive anaplastic large cell lymphoma    neural tube defects    synovial sarcoma    major depressive disorder
    basal cell carcinoma    anaplastic large cell lymphoma    breast and colorectal cancer    sarcoma
    cervical cancer    parkinson's disease    lung cancer    cervicitis
    malaria    colorectal cancer    thyroiditis


    DVL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DVL3

    Export disorders for DVL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DVL3 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with DVL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)1, 2, 3 Pizzuti A.... Dallapiccola B. (Hum. Mol. Genet. 1996)
    2. cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. (PubMed id 9344861)1, 2, 9 Bui T.D.... Harris A.L. (Biochem. Biophys. Res. Commun. 1997)
    3. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1, 4  ....Sullivan P.F. (Mol. Psychiatry 2013)
    4. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PubMed id 22863007)1, 2 Chaki M....Hildebrandt F. (Cell 2012)
    5. Delicate analysis of post-translational modifications on Dishevelled 3. (PubMed id 22612246)1, 2 Wu C.... Zeng R. (J. Proteome Res. 2012)
    6. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. (PubMed id 20227366)1, 2 Tauriello D.V.... Maurice M.M. (Mol. Cell 2010)
    7. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. (PubMed id 15677333)1, 2 Liu J....Schultz P.G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Regulation of the Wnt signaling pathway by disabled-2 (Dab2). (PubMed id 12805222)1, 2 Howe P.H. (EMBO J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1857 HGNC: 3087 AceView: DVL3 Ensembl:ENSG00000161202 euGenes: HUgn1857
    ECgene: DVL3 Kegg: 1857 H-InvDB: DVL3

    (According to HUGE)
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    HUGE: KIAA0208

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DVL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DVL3 gene:
    Search GeneIP for patents involving DVL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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