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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DVL3 Gene

protein-coding GIFtS: 65
GCID: GC03P183873

dishevelled, dsh homolog 3 (Drosophila)

(Previous name: dishevelled 3 (homologous to Drosophila dsh) )

Explore 14 diseases affiliated with
DVL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dishevelled, Dsh Homolog 3 (Drosophila)¹ ²		Dishevelled-3³
Dishevelled 3 (Homologous To Drosophila Dsh)¹ ²		Segment Polarity Protein Dishevelled Homolog DVL-3²
KIAA0208¹ ³		Dishevelled-3³
DSH Homolog 3² ³

External Ids:	HGNC: 3087¹	Entrez Gene: 1857²	Ensembl: ENSG00000161202⁷	OMIM: 601368⁵	UniProtKB: Q92997³

Export aliases for DVL3 gene to outside databases

Previous GC identifers: GC03M180749 GC03P184867 GC03P185275 GC03P185194 GC03P185357 GC03P185358 GC03P185360 GC03P181280

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DVL3:

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh.

The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997

Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Gene Wiki entry for DVL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DVL3 gene promoter:
TBP MyoD Arnt YY1 CREB HEN1 FAC1 POU2F1 Ik-2 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DVL3 promoter sequence

Search SABiosciences Chromatin IP Primers for DVL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DVL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27

DVL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL3 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P183873: view genomic region (about GC identifiers)

Start:	183,873,176 bp from pter	End:	183,891,398 bp from pter
Size:	18,223 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997 (See protein sequence)

Recommended Name: Segment polarity protein dishevelled homolog DVL-3

Size: 716 amino acids; 78055 Da

Subunit: Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts

(via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction.

Interacts with CYLD, CEP164 and DAB2

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=BAA13199.2; Type=Erroneous initiation;

Secondary accessions: D3DNT0 O14642 Q13531 Q8N5E9 Q92607

Explore the universe of human proteins at neXtProt for DVL3: NX_Q92997

Post-translational modifications:

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains¹

Phosphorylated by CSNK1D¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92997

DVL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004414.3

ENSEMBL proteins:

ENSP00000316054 ENSP00000412345 ENSP00000405885 ENSP00000393849

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for DVL3
	GenScript Custom Purified and Recombinant Proteins Services for DVL3
	Novus Biologicals DVL3 Proteins Novus Biologicals DVL3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DVL3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	--	--
GO:0005938	cell cortex	IBA	--

DVL3 for ontologies About GeneDecksing

DVL3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL3
	R&D Systems Antibodies for DVL3 (Dishevelled-3)
	Cell Signaling Technology (CST) Antibodies for DVL3
	OriGene Antibodies: DVL3 OriGene Custom Antibody Services for DVL3
	GenScript Custom Superior Antibodies Services for DVL3
	Novus Biologicals DVL3 Antibodies
	Abcam antibodies for DVL3
	Uscn Antibodies for DVL3
	ThermoFisher Antibodies for DVL3

Assay Products for DVL3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DVL3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DVL3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DVL3 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR001478 PDZ

IPR024580 Dishevelled_C-dom

IPR008342 Dishevelled_3

IPR015506 Dsh/Dvl-rel

Graphical View of Domain Structure for InterPro Entry Q92997

ProtoNet protein and cluster: Q92997

4 Blocks protein families:

IPB000591 Pleckstrin putative G-protein interacting domain

IPB001478 PDZ/DHR/GLGF domain

IPB003351 Dishevelled protein

IPB008339 Dishevelled protein signature

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997

Similarity: Belongs to the DSH family

Similarity: Contains 1 DEP domain

Similarity: Contains 1 DIX domain

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DVL3_HUMAN, Q92997

Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Genatlas biochemistry entry for DVL3:

Drosophila dishevelled segment polarity gene homolog 3,widely expressed,putatively involved in neural and heart

development,activated in WNT signal transduction

miRNA Products:		OriGene 3'-UTR Clone: DVL3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DVL3
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL3 (see all 65):
		hsa-miR-548j hsa-miR-193a-3p hsa-miR-548a-5p hsa-miR-4293 hsa-miR-193b hsa-miR-4324 hsa-miR-647 hsa-miR-559

		SwitchGear 3'UTR luciferase reporter plasmid: DVL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DVL3 (see all 7) OriGene shRNA RFP: DVL3 OriGene siRNA: DVL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DVL3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DVL3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DVL3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DVL3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DVL3 (NM_004423)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DVL3
		Search LifeMap BioReagents cell lines for DVL3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL3

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	--
GO:0004871	signal transducer activity	IEA	--
GO:0005102	receptor binding	IPI	17030191
GO:0005109	frizzled binding	IPI	19388021
GO:0005515	protein binding	IPI	10330181

DVL3 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for DVL3:

Downregulation of NF-kappaB pa	Downregulation of NF-kappaB pa	Increased Salmonella enterica	Increased cell number in G2M,
Synthetic lethal with Ras

Animal Models:
Mouse knock-out Dvl3^tm1Awb for DVL3
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dvl3):

cardiovascular system	craniofacial	embryogenesis	growth/size	hearing/vestibular/ear
homeostasis/metabolism	limbs/digits/tail	mortality/aging	nervous system	respiratory system
skeleton

DVL3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35	Wnt Signaling Pathway NetPath	0.22

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Basal cell carcinoma

Basal cell carcinoma

1.00

Melanogenesis

0.32

Notch Signaling Pathway

Notch Signaling Pathway

1.00

Notch signaling pathway

0.82

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DVL3

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for DVL3

Wnt Signaling Pathway

1 Cell Signaling Technology (CST) Pathway for DVL3

Wnt / Hedgehog / Notch

2 GeneGo (Thomson Reuters) Pathways for DVL3

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/9 BioSystems Pathways for DVL3 (see all 9)

	DNA damage response (only ATM dependent)
	Neural Crest Differentiation
	Wnt Signaling Pathway and Pluripotency
	Notch Signaling Pathway
	Wnt Signaling Pathway

5 Kegg Pathways (Kegg details for DVL3):

	Wnt signaling pathway
	Notch signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

DVL3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DVL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/208 Interacting proteins for DVL3 (Q92997^{1, 2, 3} ENSP00000316054⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 208)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AXIN1	O15169²^,³, ENSP00000262320⁴	MINT-8284998 MINT-8277609 I2D: score=4 STRING: ENSP00000262320
PPM1A	P35813²^,³, ENSP00000327255⁴	MINT-8284998 MINT-8277609 I2D: score=3 STRING: ENSP00000327255
WT1	P19544²^,³, ENSP00000331327⁴	MINT-8277130 I2D: score=3 STRING: ENSP00000331327
PIK3CB	P42338²^,³, ENSP00000289153⁴	MINT-8266161 I2D: score=2 STRING: ENSP00000289153
LRRFIP2	Q9Y608¹^,³, ENSP00000338727⁴	EBI-739789,EBI-1023718 I2D: score=1 STRING: ENSP00000338727

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001934	positive regulation of protein phosphorylation	IMP	--
GO:0003007	heart morphogenesis	--	--
GO:0003148	outflow tract septum morphogenesis	IBA	--
GO:0007275	multicellular organismal development	--	--
GO:0016055	Wnt receptor signaling pathway	IDA	10644691

DVL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DVL3
Search CenterWatch for drugs/clinical trials and news about DVL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DVL3 gene:

NM_004423.3

Unigene Cluster for DVL3:

Dishevelled, dsh homolog 3 (Drosophila)

Hs.388116 [show with all ESTs]

Unigene Representative Sequence: D86963

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000313143(uc003fms.3 uc011bqw.2 uc003fmt.3 uc003fmu.3)

ENST00000435708 ENST00000431765 ENST00000462665 ENST00000423300 ENST00000478247

ENST00000467873 ENST00000478639

miRNA Products:		OriGene 3'-UTR Clone: DVL3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DVL3
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL3 (see all 65):
		hsa-miR-548j hsa-miR-193a-3p hsa-miR-548a-5p hsa-miR-4293 hsa-miR-193b hsa-miR-4324 hsa-miR-647 hsa-miR-559

		SwitchGear 3'UTR luciferase reporter plasmid: DVL3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DVL3 (see all 7) OriGene shRNA RFP: DVL3 OriGene siRNA: DVL3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DVL3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DVL3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DVL3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DVL3 (NM_004423)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL3
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DVL3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DVL3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL3

Additional cDNA sequence:

AF006013.1 AK093469.1 AK304686.1 AL110278.1 BC018289.1 BC032459.1 D86963.1 U48252.1

U49262.1 U75651.1

20 DOTS entries:

DT.315588 DT.315589 DT.100751578 DT.100037368 DT.97861544 DT.95090999 DT.91905805 DT.95269593

DT.95269607 DT.100037366 DT.120901374 DT.91758519 DT.92033526 DT.120654 DT.92001890 DT.95269549

DT.100752261 DT.100800143 DT.95146251 DT.95269597

24/324 AceView cDNA sequences (see all 324):

CA310212 BM703610 BU146077 BU726267 AI239718 CK822981 CD674170 R80505

BQ897563 BU623828 BC018289 BM706148 BQ689957 BM680907 D86963 CF135806

CK822982 AA358549 CA438588 BM746665 AK093469 AA044175 AI240261 BM893571

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DVL3 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:					-		-		-										-										-
SP2:									-										-										-										-		-
SP3:
SP4:							-		-
SP5:					-		-		-

ExUns:	19a	·	19b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DVL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DVL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAACCCCA

About this image
See DVL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DVL3

SOURCE GeneReport for Unigene cluster: Hs.388116

SABiosciences Expression via Pathway-Focused PCR Array including DVL3:

Neurogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DVL3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DVL3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DVL3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DVL3 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dvl3^{1 , 5}	dishevelled 3, dsh homolog (Drosophila)^{1, 5}	90.78(n)¹ 99.02(a)¹		16 (12.46 cM)⁵ 13544¹ NM_007889.2¹ NP_031915.2¹ 20516982⁵
chicken (Gallus gallus)	Aves	DVL3¹	dishevelled, dsh homolog 3 (Drosophila)	82.86(n) 91.33(a)		424949 XM_422756.3 XP_422756.3
lizard (Anolis carolinensis)	Reptilia	DVL3⁶ --	--	88(a) 49(a)	1 ↔ 1 possible ortholog	GL343245.1(1590026-1638435) AAWZ02041057(3290-5409)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.6892²	Transcribed sequence with moderate similarity to protein more	78.22(n)		AL958553.2
zebrafish (Danio rerio)	Actinopterygii	LOC100149082¹	segment polarity protein dishevelled homolog DVL-3-like	73.17(n) 81.07(a)		100149082 XM_001920207.3 XP_001920242.3
fruit fly (Drosophila melanogaster)	Insecta	dsh^{1 , 3}	cell motility Notch binding³ dishevelled¹	54(a)³ 56.36(n)¹ 52.9(a)¹		32078¹ NM_078563.3¹ NP_511118.2¹
worm (Caenorhabditis elegans)	Secernentea	dsh-1⁶ dsh-2⁶ (see all 3)	DiSHevelled related family member (dsh-2) (see all 3)	33(a) 27(a) (see all 3)	possible ortholog possible ortholog (see all 3)	II(5214430-5225361) II(5078202-5081153)

ENSEMBL Gene Tree for DVL3 (if available)
TreeFam Gene Tree for DVL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DVL3 gene

DVL1² DVL2²

5 SIMAP similar genes for DVL3 using alignment to 5 protein entries: DVL3_HUMAN (see all proteins):

DKFZp586M1622 DVL2 DVL1L1 DVL1 DLG4

DVL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151019529^1,2		--	183871329(+)	`TTGAAC/TAGGGA`	1	--	us2k¹		0	--	--	--	--
rs184606507^1,2		--	183871680(+)	`TGGAAA/GAAGTT`	1	--	us2k¹		0	--	--	--	--
rs140925012^1,2		--	183871690(+)	`TTTCTC/TTAACC`	1	--	us2k¹		0	--	--	--	--
rs2943480^1,2	C	--	183871722(-)	`ACCAAA/CACAAA`	1	--	us2k¹		0	--	--	--	--
rs2943479^1,2	C	--	183871736(-)	`ACAAAA/CACAAA`	1	--	us2k¹		0	--	--	--	--
rs864577^1,2	C,F,A,	--	183871880(-)	`GTGGCA/GCATGC`	1	--	us2k¹		5		NA WA	10
rs141600716^1,2		--	183871888(+)	`CACCAG/TGTCCA`	1	--	us2k¹		0	--	--	--	--
rs190504651^1,2		--	183872095(+)	`AGTTAA/TGTATT`	1	--	us2k¹		0	--	--	--	--
rs114806381^1,2	F,	--	183872100(+)	`TGTATT/ATACAA`	1	--	us2k¹		1		NA	120
rs149623226^1,2		--	183872200(+)	`CACAGC/TAGGCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DVL3 (183873176 - 183891398 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DVL3
2 CNVs: 98553 4364
1 Indel: 62129
Human Gene Mutation Database (HGMD): DVL3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DVL3 for disorders           About GeneDecksing

OMIM gene information: 601368    OMIM disorders: --

14 diseases for DVL3:    About MalaCards

fetal alcohol syndrome synovial sarcoma basal cell carcinoma alcoholism

liver cancer sarcoma colon carcinoma lung cancer

carcinoma neuronitis

Export disorders for DVL3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DVL3 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with DVL3)

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cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)^{1, 2, 3} Pizzuti A.... Dallapiccola B. (1996)
cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas. (PubMed id 9344861)^{1, 2, 9} Bui T.D.... Harris A.L. (1997)
Delicate analysis of post-translational modifications on Dishevelled 3. (PubMed id 22612246)^{1, 2} Wu C.... Zeng R. (2012)
Loss of the tumor suppressor CYLD enhances Wnt/beta-c atenin signaling through K63-linked ubiquitination of Dvl. (PubMed id 20227366)^{1, 2} Tauriello D.V....Maurice M.M. (2010)
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. (PubMed id 15677333)^{1, 2} Liu J....Schultz P.G. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of the Wnt signaling pathway by disabled-2 (Dab2). (PubMed id 12805222)^{1, 2} Hocevar B.A....Howe P.H. (2003)
Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)^{1, 2} Semenov M.V. and Snyder M. (1997)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. (PubMed id 18093802)^{1, 9} Lee Y.N....Wang H.Y. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1857	HGNC: 3087	AceView: DVL3	Ensembl:ENSG00000161202	euGenes: HUgn1857
ECgene: DVL3	Kegg: 1857	H-InvDB: DVL3

(According to HUGE)
About This Section

HUGE: KIAA0208

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DVL3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DVL3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DVL3 gene:
Search GeneIP for patents involving DVL3

GeneCards and IP:
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dishevelled, dsh homolog 3 (Drosophila)

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dishevelled, dsh homolog 3 (Drosophila)

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