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DVL2 Gene

protein-coding   GIFtS: 69
GCID: GC17M007128

Dishevelled Segment Polarity Protein 2

(Previous names: dishevelled 2 (homologous to Drosophila dsh), dishevelled,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dishevelled Segment Polarity Protein 21 2     Segment Polarity Protein Dishevelled Homolog DVL-22
Dishevelled 2 (Homologous To Drosophila Dsh)1 2     Dishevelled-23
Dishevelled, Dsh Homolog 2 (Drosophila)1     DSH Homolog 23
Dishevelled, Dsh Homolog 22     

External Ids:    HGNC: 30861   Entrez Gene: 18562   Ensembl: ENSG000000049757   OMIM: 6021515   UniProtKB: O146413   

Export aliases for DVL2 gene to outside databases

Previous GC identifers: GC17M007526 GC17M007858 GC17M007071 GC17M007329 GC17M007069 GC17M007021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DVL2 Gene:
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately
40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes
posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal
transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling
are likely to be conserved among metazoans. (provided by RefSeq, Jul 2008)

GeneCards Summary for DVL2 Gene:
DVL2 (dishevelled segment polarity protein 2) is a protein-coding gene. Diseases associated with DVL2 include alk-positive anaplastic large cell lymphoma, and neural tube defects. GO annotations related to this gene include identical protein binding and protein domain specific binding. An important paralog of this gene is DVL1.

UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641
Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and
transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled
proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the
signal transduction pathways mediated by multiple Wnt genes (By similarity)

Gene Wiki entry for DVL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DVL2 gene promoter:
         COUP-TF1   AP-2alpha isoform 3   COUP   HNF-4alpha2   AP-2alpha isoform 2   HNF-4alpha1   COUP-TF   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDVL2 promoter sequence
   Search Chromatin IP Primers for DVL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DVL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

DVL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007128:  view genomic region     (about GC identifiers)

Start:
7,128,660 bp from pter      End:
7,137,864 bp from pter
Size:
9,205 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641 (See protein sequence)
Recommended Name: Segment polarity protein dishevelled homolog DVL-2  
Size: 736 amino acids; 78948 Da
Subunit: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac.
Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large
oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain)
with AP2M1 and the AP-2 complex (By similarity). Interacts with DACT1 and FAM105B/otulin
5 PDB 3D structures from and Proteopedia for DVL2:
2REY (3D)        3CBX (3D)        3CBY (3D)        3CBZ (3D)        3CC0 (3D)    
Secondary accessions: D3DTN3 Q53XM0

Explore the universe of human proteins at neXtProt for DVL2: NX_O14641

Explore proteomics data for DVL2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CSNK1D1
  • Ubiquitination2 at Lys301, Lys343, Lys353, Lys428, Lys477, Lys484, Lys615
  • Modification sites at PhosphoSitePlus

  • See DVL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004413.1  
    ENSEMBL proteins: 
     ENSP00000005340   ENSP00000459797   ENSP00000458465   ENSP00000459991   ENSP00000458209  
    Reactome Protein details: O14641

    DVL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DVL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DVL2
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    Novus Biologicals DVL2 Protein
    Novus Biologicals DVL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DVL2

    DVL2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL2
    R&D Systems Antibodies for DVL2 (Dishevelled-2)
    Cell Signaling Technology (CST) Antibodies for DVL2 
    OriGene Antibodies for DVL2
    OriGene Custom Antibody Services for DVL2
    Novus Biologicals DVL2 Antibodies
    Abcam antibodies for DVL2
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    ThermoFisher Antibodies for DVL2
    LSBio Antibodies in human, mouse, rat for DVL2

    DVL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DVL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DVL2
    Cloud-Clone Corp. CLIAs for DVL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DVL: Dishevelled homologs

    Selected InterPro protein domains (see all 9):
     IPR011991 WHTH_DNA-bd_dom
     IPR008341 Dishevelled_2
     IPR001478 PDZ
     IPR024580 Dishevelled_C-dom
     IPR015506 Dsh/Dvl-rel

    Graphical View of Domain Structure for InterPro Entry O14641

    ProtoNet protein and cluster: O14641

    4 Blocks protein domains:
    IPB000591 Pleckstrin putative G-protein interacting domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB003351 Dishevelled protein
    IPB008339 Dishevelled protein signature


    UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641
    Domain: The DIX domain mediates homooligomerization (By similarity)
    Similarity: Belongs to the DSH family
    Similarity: Contains 1 DEP domain
    Similarity: Contains 1 DIX domain
    Similarity: Contains 1 PDZ (DHR) domain


    DVL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DVL2_HUMAN, O14641
    Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and
    transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled
    proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the
    signal transduction pathways mediated by multiple Wnt genes (By similarity)

         Genatlas biochemistry entry for DVL2:
    Drosophila dishevelled segment polarity gene homolog 2,908,95kDa,widely expressed in embryo,activated in WNT
    signal transduction

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005109frizzled binding IPI19388021
    GO:0005515protein binding IPI10644691
    GO:0019904protein domain specific binding IEA--
    GO:0042802identical protein binding IPI16189514
         
    DVL2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DVL2:
     Decreased Wnt reporter activit  Increased HPV18 LCR reporter a  Increased viability with TRAIL  Synthetic lethal with gemcitab 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dvl2):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  nervous system  normal 
     skeleton 

    DVL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dvl2tm1Awb for DVL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DVL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DVL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DVL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DVL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DVL2:
    hsa-mir-124-3p (MIRT002652), hsa-mir-221-3p (MIRT024149), hsa-mir-484 (MIRT041680), hsa-mir-324-3p (MIRT004684)

    Block miRNA regulation of human, mouse, rat DVL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DVL2 (see all 12):
    hsa-miR-137 hsa-miR-300 hsa-miR-27a hsa-miR-381 hsa-miR-128 hsa-miR-3681* hsa-miR-1911* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidDVL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DVL2
    Predesigned siRNA for gene silencing in human, mouse, rat DVL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DVL2

    Clone
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    OriGene ORF clones in mouse, rat for DVL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DVL2 (NM_004422)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DVL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DVL2_HUMAN, O14641: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm,
    cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon
    interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus4
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IBA--

    DVL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DVL2 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Notch Signaling Pathway0.84
    3CDK-mediated phosphorylation and removal of Cdc6
    Asymmetric localization of PCP proteins0.75
    WNT5A-dependent internalization of FZD40.00
    PCP/CE pathway0.70
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DVL2
        Wnt Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for DVL2
        Wnt / Hedgehog / Notch

    2 GeneGo (Thomson Reuters) Pathways for DVL2
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for DVL2 (see all 8)
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Notch Signaling Pathway
    Neural Crest Differentiation

    Selected Reactome Pathways for DVL2 (see all 8)
        Signaling by Hippo
    WNT5A-dependent internalization of FZD4
    TCF dependent signaling in response to WNT
    Asymmetric localization of PCP proteins
    degradation of DVL


    Selected Kegg Pathways  (Kegg details for DVL2) (see all 7):
        Wnt signaling pathway
    Notch signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    DVL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DVL2: 
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DVL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DVL2 (O146411, 2, 3 ENSP000000053404) via UniProtKB, MINT, STRING, and/or I2D (see all 469)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250542, 3, ENSP000002574304MINT-7890898 MINT-7897032 MINT-7897075 I2D: score=2 STRING: ENSP00000257430
    TP53P046372, 3, ENSP000002693054MINT-2858243 MINT-67597 I2D: score=5 STRING: ENSP00000269305
    ZNF263O149782, 3, ENSP000002190694MINT-67784 I2D: score=5 STRING: ENSP00000219069
    DVL1O146402, 3, ENSP000003681694MINT-7897032 MINT-7897075 I2D: score=4 STRING: ENSP00000368169
    CSNK1EP496742, 3, ENSP000003529294MINT-67492 I2D: score=8 STRING: ENSP00000352929
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ISS--
    GO:0001934positive regulation of protein phosphorylation IMP--
    GO:0003007heart morphogenesis IBA--
    GO:0003151outflow tract morphogenesis ISS--
    GO:0006366transcription from RNA polymerase II promoter IDA11742073

    DVL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DVL2

    1 Novoseek inferred chemical compound relationship for DVL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 41.6 1 11290401 (1)



    DVL2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DVL2 gene: 
    NM_004422.2  

    Unigene Cluster for DVL2:

    Dishevelled, dsh homolog 2 (Drosophila)
    Hs.118640  [show with all ESTs]
    Unigene Representative Sequence: NM_004422
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000005340(uc002gez.1 uc010vtr.1 uc010vts.1) ENST00000575458
    ENST00000575086 ENST00000576840 ENST00000571745 ENST00000576285 ENST00000573354
    ENST00000575756 ENST00000574143 ENST00000574591 ENST00000577154 ENST00000574642
    ENST00000572285(uc010clz.1) ENST00000576439 ENST00000576949
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DVL2 (see all 12):
    hsa-miR-137 hsa-miR-300 hsa-miR-27a hsa-miR-381 hsa-miR-128 hsa-miR-3681* hsa-miR-1911* hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidDVL2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: DVL2 (NM_004422)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DVL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DVL2
      QuantiTect SYBR Green Assays in human, mouse, rat DVL2
      QuantiFast Probe-based Assays in human, mouse, rat DVL2

    Additional mRNA sequence: 

    AF006012.1 AK026019.1 AK297099.1 AK297285.1 AK304229.1 AK309771.1 AK312829.1 BC014844.1 
    BT009822.1 

    19 DOTS entries:

    DT.414897  DT.95147083  DT.92458630  DT.100764736  DT.40306577  DT.120903107  DT.95173274  DT.120903163 
    DT.40123504  DT.100813719  DT.101979095  DT.102831218  DT.92458625  DT.120903103  DT.120903124  DT.120903159 
    DT.92458622  DT.97846227  DT.95173276 

    Selected AceView cDNA sequences (see all 173):

    BM711500 CA950115 BQ880657 BG056832 BG818043 BM469690 AA812964 CA311447 
    AW275025 CA943901 BM457001 NM_004422 BT009822 BM552604 BQ055061 AI394693 
    AL520581 BM759894 BM784381 CD672716 CD618706 BQ224334 BF512810 BM717165 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DVL2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^
    SP1:                    -                 -                                               -                                         -           -               
    SP2:                                      -                       -                       -                                                                     
    SP3:                    -                 -                       -                       -                                                                     
    SP4:                                                              -                       -                                         -                           
    SP5:                                      -                       -     -     -           -                                                                     

    ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DVL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DVL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCTGCCTT
    DVL2 Expression
    About this image


    DVL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Hair (Integumentary System)
             Outer Root Sheath Cells Outer Root Sheath
     
     Neural Tube (Nervous System)
             Metencephalon
    DVL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DVL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118640
        Pathway & Disease-focused RT2 Profiler PCR Array including DVL2: 
              WNT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DVL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dvl21 , 5 dishevelled 2, dsh homolog (Drosophila)1, 5 88.21(n)1
    96.69(a)1
      11 (42.96 cM)5
    135431  NM_007888.31  NP_031914.31 
     700005955 
    lizard
    (Anolis carolinensis)
    Reptilia DVL26
    dishevelled segment polarity protein 2
    88(a)
    1 ↔ 1
    AAWZ02037606(263-12658)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76702 Xenopus laevis dishevelled homolog (Xdsh) mRNA, complete more 76.66(n)    U31552.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.53982 Danio rerio mRNA similar to dishevelled 2, dsh homolog more 79.45(n)    BC044381.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dsh3 cell motility Notch binding 61(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea dsh-11 dsh-1 47.43(n)
    44.61(a)
      173894  NM_062577.5  NP_494978.4 


    ENSEMBL Gene Tree for DVL2 (if available)
    TreeFam Gene Tree for DVL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DVL2 gene
    DVL12  DVL32  DIXDC12  
    5 SIMAP similar genes for DVL2 using alignment to 5 protein entries:     DVL2_HUMAN (see all proteins):
    DKFZp586M1622    DVL3    DVL1P1    DLG4    DVL1

    DVL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DVL2 (see all 313)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837040161,2
    --7129122(+) GCACAC/TGACGG 1 -- ut310--------
    rs1862270851,2
    --7129141(+) CCCAGC/TCACAC 1 -- ut310--------
    rs1903425281,2
    --7129143(+) CAGTCA/CCACAC 1 -- ut310--------
    rs2014512631,2
    --7129155(+) AGGAGC/TGCCCG 1 -- ut310--------
    rs2011146311,2
    C--7129192(+) CATAAC/TATCCA 2 I V mis10--------
    rs1392298641,2
    C--7129238(+) AAGCTT/CTGGCG 2 /Q syn11Minor allele frequency- C:0.00NA 3778
    rs2019478621,2
    --7129277(+) CCCAGC/GTCTCT 2 D E mis10--------
    rs2014250141,2
    C--7129298(+) GCCCCC/G/TGGAGG 3 P syn10--------
    rs1414339721,2
    C,F--7129332(+) GTGGAG/AGTGGG 2 /P /L mis11Minor allele frequency- A:0.01NA 3824
    rs1476100251,2
    C--7129360(+) CATGGG/AGTTGT 2 /P /S mis11Minor allele frequency- A:0.00NA 3996

    HapMap Linkage Disequilibrium report for DVL2 (7128660 - 7137864 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DVL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv1962CNV Insertion18451855
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv457659CNV Loss19166990

    Human Gene Mutation Database (HGMD): DVL2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DVL2
    DNA2.0 Custom Variant and Variant Library Synthesis for DVL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602151    OMIM disorders: --

    18 diseases for DVL2:    
    About MalaCards
    alk-positive anaplastic large cell lymphoma    neural tube defects    mantle cell lymphoma    synovial sarcoma
    basal cell carcinoma    anaplastic large cell lymphoma    cleft palate    cleft lip
    sarcoma    schizophrenia    pancreatic cancer    ataxia
    parkinson's disease    pancreatitis    lung cancer    prostate cancer
    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for DVL2:
    Double outlet right ventricle

    DVL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DVL2
    Human Genome Epidemiology (HuGE) Navigator: DVL2 (6 documents)

    Export disorders for DVL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DVL2 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with DVL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. (PubMed id 23708998)1, 2 Rivkin E.... Cordes S.P. (Nature 2013)
    2. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. (PubMed id 20219685)1, 4 Inkster B....Matthews P.M. (Neuroimage 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PubMed id 15262978)1, 2 Wong C.K.... Lin S.-C. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. (PubMed id 11742073)1, 2 Chen W.... Miller W.E. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    8. Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)1, 2 Semenov M.V. and Snyder M. (Genomics 1997)
    9. Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. (PubMed id 8662242)1, 3 Greco T.L....Camper S.A. (Mamm. Genome 1996)
    10. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. (PubMed id 10829020)1, 9 Zhang Y....Lin S.C. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1856 HGNC: 3086 AceView: DVL2 Ensembl:ENSG00000004975 euGenes: HUgn1856
    ECgene: DVL2 Kegg: 1856 H-InvDB: DVL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DVL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DVL2 gene:
    Search GeneIP for patents involving DVL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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