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Aliases for DVL2 Gene

Aliases for DVL2 Gene

  • Dishevelled Segment Polarity Protein 2 2 3
  • Dishevelled 2 (Homologous To Drosophila Dsh) 2
  • Dishevelled, Dsh Homolog 2 (Drosophila) 2
  • DSH Homolog 2 4
  • Dishevelled-2 4

External Ids for DVL2 Gene

Previous GeneCards Identifiers for DVL2 Gene

  • GC17M007526
  • GC17M007858
  • GC17M007071
  • GC17M007329
  • GC17M007069
  • GC17M007128
  • GC17M007021

Summaries for DVL2 Gene

Entrez Gene Summary for DVL2 Gene

  • This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

GeneCards Summary for DVL2 Gene

DVL2 (Dishevelled Segment Polarity Protein 2) is a Protein Coding gene. Diseases associated with DVL2 include conotruncal heart malformations. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include identical protein binding and protein self-association. An important paralog of this gene is DIXDC1.

UniProtKB/Swiss-Prot for DVL2 Gene

  • Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).

Gene Wiki entry for DVL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DVL2 Gene

Genomics for DVL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DVL2 Gene

Chromosome:
17
Start:
7,225,341 bp from pter
End:
7,234,548 bp from pter
Size:
9,208 bases
Orientation:
Minus strand

Genomic View for DVL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DVL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DVL2 Gene

Proteins for DVL2 Gene

  • Protein details for DVL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14641-DVL2_HUMAN
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-2
    Protein Accession:
    O14641
    Secondary Accessions:
    • D3DTN3
    • Q53XM0

    Protein attributes for DVL2 Gene

    Size:
    736 amino acids
    Molecular mass:
    78948 Da
    Quaternary structure:
    • Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). Interacts with DACT1 and FAM105B/otulin. Interacts with DCDC2.

    Three dimensional structures from OCA and Proteopedia for DVL2 Gene

neXtProt entry for DVL2 Gene

Proteomics data for DVL2 Gene at MOPED

Post-translational modifications for DVL2 Gene

  • Phosphorylated by CSNK1D.
  • Ubiquitination at Lys 343, Lys 353, Lys 428, Lys 477, Lys 484, and Lys 615
  • Modification sites at PhosphoSitePlus

Other Protein References for DVL2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DVL2 (DVL2)

No data available for DME Specific Peptides for DVL2 Gene

Domains & Families for DVL2 Gene

Gene Families for DVL2 Gene

Suggested Antigen Peptide Sequences for DVL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14641

UniProtKB/Swiss-Prot:

DVL2_HUMAN :
  • The DIX domain mediates homooligomerization.
  • Belongs to the DSH family.
Domain:
  • The DIX domain mediates homooligomerization.
  • Contains 1 DEP domain.
  • Contains 1 DIX domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the DSH family.
genes like me logo Genes that share domains with DVL2: view

Function for DVL2 Gene

Molecular function for DVL2 Gene

GENATLAS Biochemistry:
Drosophila dishevelled segment polarity gene homolog 2,908,95kDa,widely expressed in embryo,activated in WNT signal transduction
UniProtKB/Swiss-Prot Function:
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).

Gene Ontology (GO) - Molecular Function for DVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005109 frizzled binding IPI 19388021
GO:0005515 protein binding IPI 10644691
GO:0019904 protein domain specific binding IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with DVL2: view
genes like me logo Genes that share phenotypes with DVL2: view

Animal Models for DVL2 Gene

MGI Knock Outs for DVL2:

Animal Model Products

miRNA for DVL2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DVL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DVL2 Gene

Localization for DVL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DVL2 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DVL2 Gene COMPARTMENTS Subcellular localization image for DVL2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 3
golgi apparatus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 9192851
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0030136 clathrin-coated vesicle --
genes like me logo Genes that share ontologies with DVL2: view

Pathways & Interactions for DVL2 Gene

genes like me logo Genes that share pathways with DVL2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for DVL2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DVL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure ISS --
GO:0001934 positive regulation of protein phosphorylation IMP 20137080
GO:0003007 heart morphogenesis --
GO:0003151 outflow tract morphogenesis ISS --
GO:0006366 transcription from RNA polymerase II promoter IDA 11742073
genes like me logo Genes that share ontologies with DVL2: view

Drugs & Compounds for DVL2 Gene

(1) Additional Compounds for DVL2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
genes like me logo Genes that share compounds with DVL2: view

Transcripts for DVL2 Gene

Unigene Clusters for DVL2 Gene

Dishevelled, dsh homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DVL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DVL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: -
SP9: -
SP10:

ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DVL2 Gene

GeneLoc Exon Structure for
DVL2
ECgene alternative splicing isoforms for
DVL2

Expression for DVL2 Gene

mRNA expression in normal human tissues for DVL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DVL2 Gene

This gene is overexpressed in Ovary (15.4), Fetal testis (8.4), and Fetal ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DVL2 Gene



SOURCE GeneReport for Unigene cluster for DVL2 Gene Hs.118640

genes like me logo Genes that share expression patterns with DVL2: view

Protein tissue co-expression partners for DVL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DVL2 Gene

Orthologs for DVL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DVL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DVL2 35
  • 90.56 (n)
  • 97.64 (a)
DVL2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DVL2 35
  • 90.15 (n)
  • 97.51 (a)
DVL2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dvl2 35
  • 88.21 (n)
  • 96.69 (a)
Dvl2 16
Dvl2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DVL2 35
  • 99.73 (n)
  • 100 (a)
DVL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dvl2 35
  • 87.85 (n)
  • 96.27 (a)
oppossum
(Monodelphis domestica)
Mammalia DVL2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DVL2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DVL2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dvl2 35
  • 73.3 (n)
  • 79.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7670 35
zebrafish
(Danio rerio)
Actinopterygii Dr.5398 35
dvl2 35
  • 69.98 (n)
  • 75.6 (a)
dvl2 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dsh 37
  • 61 (a)
dsh 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dsh-1 35
  • 47.43 (n)
  • 44.61 (a)
dsh-1 36
  • 26 (a)
ManyToMany
dsh-2 36
  • 30 (a)
ManyToMany
mig-5 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11084 36
  • 48 (a)
OneToMany
Species with no ortholog for DVL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DVL2 Gene

ENSEMBL:
Gene Tree for DVL2 (if available)
TreeFam:
Gene Tree for DVL2 (if available)

Paralogs for DVL2 Gene

Paralogs for DVL2 Gene

(5) SIMAP similar genes for DVL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DVL2: view

Variants for DVL2 Gene

Sequence variations from dbSNP and Humsavar for DVL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs222835 -- 7,230,810(-) TACCT(C/T)GTCGC intron-variant
rs222836 -- 7,229,843(-) ACCAG(C/T)CTGGG reference, synonymous-codon
rs222837 -- 7,229,237(+) TTGCT(A/C/G/T)TGGCC synonymous-codon, reference
rs1063967 -- 7,226,160(-) AAGTG(A/G)GACTA missense, reference, downstream-variant-500B
rs2074216 -- 7,230,290(+) TGGAA(A/G)GATGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DVL2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv1962 CNV Insertion 18451855

Variation tolerance for DVL2 Gene

Residual Variation Intolerance Score: 40.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DVL2 Gene

HapMap Linkage Disequilibrium report
DVL2
Human Gene Mutation Database (HGMD)
DVL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DVL2 Gene

Disorders for DVL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DVL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • double-outlet right ventricle
- elite association
Search DVL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DVL2

Genetic Association Database (GAD)
DVL2
Human Genome Epidemiology (HuGE) Navigator
DVL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DVL2
genes like me logo Genes that share disorders with DVL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DVL2 Gene

Publications for DVL2 Gene

  1. Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells. (PMID: 20176724) Liu X. … Blackman M.R. (Endocrinology 2010) 23 67
  2. Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. (PMID: 17199046) Yu A. … Kirchhausen T. (Dev. Cell 2007) 23 67
  3. Dynamic recruitment of axin by Dishevelled protein assemblies. (PMID: 17606995) Schwarz-Romond T. … Bienz M. (J. Cell. Sci. 2007) 23 67
  4. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. (PMID: 16446366) Zhang L. … Chen Y.G. (J. Biol. Chem. 2006) 23 67
  5. Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia. (PMID: 11290401) Beasley C. … Everall I. (Neurosci. Lett. 2001) 23 67

Products for DVL2 Gene

Sources for DVL2 Gene

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