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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DVL2 Gene

protein-coding GIFtS: 66
GCID: GC17M007128

dishevelled, dsh homolog 2 (Drosophila)

(Previous name: dishevelled 2 (homologous to Drosophila dsh) )

Explore 15 diseases affiliated with
DVL2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dishevelled, Dsh Homolog 2 (Drosophila)¹ ²
Dishevelled 2 (Homologous To Drosophila Dsh)¹ ²
Segment Polarity Protein Dishevelled Homolog DVL-2²
Dishevelled-2³
DSH Homolog 2³

External Ids:	HGNC: 3086¹	Entrez Gene: 1856²	Ensembl: ENSG00000004975⁷	OMIM: 602151⁵	UniProtKB: O14641³

Export aliases for DVL2 gene to outside databases

Previous GC identifers: GC17M007526 GC17M007858 GC17M007071 GC17M007329 GC17M007069 GC17M007021

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DVL2:

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40%

amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational

phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated

by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among

metazoans. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641

Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and

transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins

upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal

transduction pathways mediated by multiple Wnt genes (By similarity)

Gene Wiki entry for DVL2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DVL2 gene promoter:
COUP-TF1 AP-2alpha isoform 3 COUP HNF-4alpha2 AP-2alpha isoform 2 HNF-4alpha1 COUP-TF AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DVL2 promoter sequence

Search SABiosciences Chromatin IP Primers for DVL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DVL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

DVL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M007128: view genomic region (about GC identifiers)

Start:	7,128,660 bp from pter	End:	7,137,864 bp from pter
Size:	9,205 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641 (See protein sequence)

Recommended Name: Segment polarity protein dishevelled homolog DVL-2

Size: 736 amino acids; 78948 Da

Subunit: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac.

Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers

(via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and

the AP-2 complex (By similarity). Interacts with DACT1

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol

(By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with

frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity)

5 PDB 3D structures from and Proteopedia for DVL2:

2REY (3D)

3CBX (3D)

3CBY (3D)

3CBZ (3D)

3CC0 (3D)

Secondary accessions: D3DTN3 Q53XM0

Explore the universe of human proteins at neXtProt for DVL2: NX_O14641

Post-translational modifications:

Phosphorylated by CSNK1D¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14641

DVL2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004413.1

ENSEMBL proteins:

ENSP00000005340 ENSP00000459797 ENSP00000458465 ENSP00000459991 ENSP00000458209

Reactome Protein details: O14641
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: DVL2 OriGene Custom Protein Services for DVL2
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	Novus Biologicals DVL2 Protein Novus Biologicals DVL2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DVL2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	9192851
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IBA	--

DVL2 for ontologies About GeneDecksing

DVL2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL2
	R&D Systems Antibodies for DVL2 (Dishevelled-2)
	Cell Signaling Technology (CST) Antibodies for DVL2
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	GenScript Custom Superior Antibodies Services for DVL2
	Novus Biologicals DVL2 Antibodies
	Abcam antibodies for DVL2
	Uscn Antibodies for DVL2
	ThermoFisher Antibodies for DVL2

Assay Products for DVL2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DVL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DVL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DVL2 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR008341 Dishevelled_2

IPR001478 PDZ

IPR024580 Dishevelled_C-dom

IPR015506 Dsh/Dvl-rel

Graphical View of Domain Structure for InterPro Entry O14641

ProtoNet protein and cluster: O14641

4 Blocks protein families:

IPB000591 Pleckstrin putative G-protein interacting domain

IPB001478 PDZ/DHR/GLGF domain

IPB003351 Dishevelled protein

IPB008339 Dishevelled protein signature

UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641

Domain: The DIX domain mediates homooligomerization (By similarity)

Similarity: Belongs to the DSH family

Similarity: Contains 1 DEP domain

Similarity: Contains 1 DIX domain

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DVL2_HUMAN, O14641

Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and

transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins

upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal

transduction pathways mediated by multiple Wnt genes (By similarity)

Genatlas biochemistry entry for DVL2:

Drosophila dishevelled segment polarity gene homolog 2,908,95kDa,widely expressed in embryo,activated in WNT signal

transduction

miRNA Products:		miRTarBase miRNAs that target DVL2: hsa-mir-324-3p (MIRT004684)

		OriGene 3'-UTR Clone: DVL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DVL2
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL2 (see all 12):
		hsa-miR-137 hsa-miR-300 hsa-miR-27a hsa-miR-381 hsa-miR-128 hsa-miR-3681* hsa-miR-1911* hsa-miR-3121-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DVL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DVL2 (see all 4) OriGene shRNA RFP: DVL2 OriGene siRNA: DVL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DVL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DVL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DVL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DVL2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DVL2 (NM_004422)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DVL2
		Search LifeMap BioReagents cell lines for DVL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--
GO:0005109	frizzled binding	IPI	19388021
GO:0005515	protein binding	IPI	--
GO:0019904	protein domain specific binding	IEA	--
GO:0042802	identical protein binding	IPI	16189514

DVL2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for DVL2:

Decreased Wnt reporter activit

Increased HPV18 LCR reporter a

Increased viability with TRAIL

Synthetic lethal with gemcitab

Animal Models:
Mouse knock-out Dvl2^tm1Awb for DVL2
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dvl2):

cardiovascular system	craniofacial	embryogenesis	growth/size	hearing/vestibular/ear
homeostasis/metabolism	limbs/digits/tail	mortality/aging	nervous system	normal
skeleton

DVL2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35	Wnt Signaling Pathway NetPath	0.22

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Basal cell carcinoma

Basal cell carcinoma

1.00

Melanogenesis

0.32

Notch Signaling Pathway

Notch Signaling Pathway

1.00

Notch signaling pathway

0.82

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DVL2

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for DVL2

Wnt Signaling Pathway

1 Cell Signaling Technology (CST) Pathway for DVL2

Wnt / Hedgehog / Notch

2 GeneGo (Thomson Reuters) Pathways for DVL2

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/8 BioSystems Pathways for DVL2 (see all 8)

	Wnt Signaling Pathway
	Notch Signaling Pathway
	Neural Crest Differentiation
	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)

2 Reactome Pathways for DVL2

	Signaling by Hippo
	Signal Transduction

5 Kegg Pathways (Kegg details for DVL2):

	Wnt signaling pathway
	Notch signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

DVL2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DVL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/317 Interacting proteins for DVL2 (O14641^{1, 2, 3} ENSP00000005340⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 317)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APC	P25054²^,³, ENSP00000257430⁴	MINT-7890898 MINT-7897032 MINT-7897075 I2D: score=2 STRING: ENSP00000257430
TP53	P04637²^,³, ENSP00000269305⁴	MINT-2858243 MINT-67597 I2D: score=5 STRING: ENSP00000269305
AXIN1	O15169²^,³, ENSP00000262320⁴	MINT-8403862 I2D: score=6 STRING: ENSP00000262320
BAHD1	Q8TBE0²^,³, ENSP00000396976⁴	MINT-67574 I2D: score=5 STRING: ENSP00000396976
PCBD1	P61457²^,³, ENSP00000299299⁴	MINT-66113 I2D: score=5 STRING: ENSP00000299299

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001843	neural tube closure	ISS	--
GO:0001934	positive regulation of protein phosphorylation	IMP	--
GO:0003007	heart morphogenesis	IBA	--
GO:0003151	outflow tract morphogenesis	ISS	--
GO:0006366	transcription from RNA polymerase II promoter	IDA	11742073

DVL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DVL2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DVL2
1 Novoseek chemical compound relationship for DVL2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	41.6	1	11290401 (1)

Search CenterWatch for drugs/clinical trials and news about DVL2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DVL2 gene:

NM_004422.2

Unigene Cluster for DVL2:

Dishevelled, dsh homolog 2 (Drosophila)

Hs.118640 [show with all ESTs]

Unigene Representative Sequence: NM_004422

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000005340(uc002gez.1 uc010vtr.1 uc010vts.1) ENST00000575458

ENST00000575086 ENST00000576840 ENST00000571745 ENST00000576285 ENST00000573354

ENST00000575756 ENST00000574143 ENST00000574591 ENST00000577154 ENST00000574642

ENST00000572285(uc010clz.1) ENST00000576439 ENST00000576949

miRNA Products:		OriGene 3'-UTR Clone: DVL2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DVL2
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL2 (see all 12):
		hsa-miR-137 hsa-miR-300 hsa-miR-27a hsa-miR-381 hsa-miR-128 hsa-miR-3681* hsa-miR-1911* hsa-miR-3121-3p

		SwitchGear 3'UTR luciferase reporter plasmid: DVL2 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: DVL2 (NM_004422)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL2

Additional cDNA sequence:

AF006012.1 AK026019.1 AK297099.1 AK297285.1 AK304229.1 AK309771.1 AK312829.1 BC014844.1

BT009822.1

19 DOTS entries:

DT.414897 DT.95147083 DT.92458630 DT.100764736 DT.40306577 DT.120903107 DT.95173274 DT.120903163

DT.40123504 DT.100813719 DT.101979095 DT.102831218 DT.92458625 DT.120903103 DT.120903124 DT.120903159

DT.92458622 DT.97846227 DT.95173276

24/173 AceView cDNA sequences (see all 173):

AI394693 BC014844 CR623783 BM784381 BM759894 BE395944 BF512810 BM552604

BM453419 BX342150 BM665518 CA950115 AW275025 BQ880657 BM717165 BT009822

BM665423 BQ224334 AA805253 CD672716 BQ055061 BG818043 AL520581 NM_004422

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DVL2 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	·	12c	^
SP1:							-						-																-														-				-
SP2:													-								-								-
SP3:							-						-								-								-
SP4:																					-								-														-
SP5:													-								-		-		-				-

ExUns:	13	^	14a	·	14b	·	14c	^	15	^	16
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DVL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DVL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCTGCCTT

About this image
See DVL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DVL2

SOURCE GeneReport for Unigene cluster: Hs.118640

SABiosciences Expression via Pathway-Focused PCR Array including DVL2:

WNT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DVL2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DVL2 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	87(a) 62(a)	1 ↔ 1 possible ortholog	AAWZ02037606(263-12038) AAWZ02041057(3290-5409)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7670²	Xenopus laevis dishevelled homolog (Xdsh) mRNA, complete more	76.66(n)		U31552.1
zebrafish (Danio rerio)	Actinopterygii	Dr.5398²	Danio rerio mRNA similar to dishevelled 2, dsh homolog more	79.45(n)		BC044381.1
fruit fly (Drosophila melanogaster)	Insecta	dsh³	cell motility Notch binding	61(a)		--
worm (Caenorhabditis elegans)	Secernentea	dsh-1⁶ dsh-2⁶ (see all 3)	DiSHevelled related family member (dsh-2) (see all 3)	33(a) 27(a) (see all 3)	possible ortholog possible ortholog (see all 3)	II(5214430-5225361) II(5078202-5081153)

ENSEMBL Gene Tree for DVL2 (if available)
TreeFam Gene Tree for DVL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DVL2 gene

DVL1² DVL3²

5 SIMAP similar genes for DVL2 using alignment to 5 protein entries: DVL2_HUMAN (see all proteins):

DKFZp586M1622 DVL3 DVL1L1 DLG4 DVL1

DVL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183704016^1,2		--	7129122(+)	`GCACAC/TGACGG`	1	--	ut3¹		0	--	--	--	--
rs186227085^1,2		--	7129141(+)	`CCCAGC/TCACAC`	1	--	ut3¹		0	--	--	--	--
rs190342528^1,2		--	7129143(+)	`CAGTCA/CCACAC`	1	--	ut3¹		0	--	--	--	--
rs201451263^1,2		--	7129155(+)	`AGGAGC/TGCCCG`	1	--	ut3¹		0	--	--	--	--
rs201114631^1,2	C,	--	7129192(+)	`CATAAC/TATCCA`	2	I V	mis¹		0	--	--	--	--
rs139229864^1,2	C,	--	7129238(+)	`AAGCTT/CTGGCG`	2	/Q	syn¹		1		NA	3778
rs201947862^1,2		--	7129277(+)	`CCCAGC/GTCTCT`	2	D E	mis¹		0	--	--	--	--
rs201425014^1,2		--	7129298(+)	`GCCCCC/GGGAGG`	2	P	syn¹		0	--	--	--	--
rs141433972^1,2	C,F,	--	7129332(+)	`GTGGAG/AGTGGG`	2	/P /L	mis¹		1		NA	3824
rs147610025^1,2	C	--	7129360(+)	`CATGGG/AGTTGT`	2	/P /S	mis¹		1		NA	3996

HapMap Linkage Disequilibrium report for DVL2 (7128660 - 7137864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DVL2: --
Human Gene Mutation Database (HGMD): DVL2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DVL2 for disorders           About GeneDecksing

OMIM gene information: 602151    OMIM disorders: --

15 diseases for DVL2:    About MalaCards

double outlet right ventricle neural tube defect mantle cell lymphoma synovial sarcoma

basal cell carcinoma sarcoma pancreatic cancer lung cancer

prostate cancer pancreatitis ataxia carcinoma

prostatitis schizophrenia neuronitis

1 disease from the University of Copenhagen DISEASES database for DVL2:

Double outlet right ventricle

Human Genome Epidemiology (HuGE) Navigator: DVL2 (6 documents)

Export disorders for DVL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DVL2 gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with DVL2)

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The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PubMed id 15262978)^{1, 2} Wong C.K.... Lin S.-C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. (PubMed id 11742073)^{1, 2} Chen W.... Miller W.E. (2001)
Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)^{1, 2} Semenov M.V. and Snyder M. (1997)
Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11. (PubMed id 8662242)^{1, 3} Greco T.L....Camper S.A. (1996)
Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. (PubMed id 10829020)^{1, 9} Zhang Y....Lin S.C. (2000)
Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. (PubMed id 16446366)^{1, 9} Zhang L....Chen Y.G. (2006)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Identification of a novel Wnt5a-CK1E-Dvl2-Plk1-mediate d primary cilia disassembly pathway. (PubMed id 22609948)¹ Lee K.H....Lee K.S. (2012)
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. (PubMed id 22655072)¹ Zhu Y....Gu L. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1856	HGNC: 3086	AceView: DVL2	Ensembl:ENSG00000004975	euGenes: HUgn1856
ECgene: DVL2	Kegg: 1856	H-InvDB: DVL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DVL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DVL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DVL2 gene:
Search GeneIP for patents involving DVL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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dishevelled, dsh homolog 2 (Drosophila)

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DVL2 Gene

dishevelled, dsh homolog 2 (Drosophila)

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