DVL1L1 Gene
pseudogene GIFtS: 29
GCID: GC22M019240
|
|
dishevelled, dsh homolog 1 (Drosophila)-like 1(Previous name: dishevelled 1-like 1 (homologous to Drosophila dsh) )
| |
Aliases
for DVL1L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dishevelled, Dsh Homolog 1 (Drosophila)-Like 11 2 | | DSH2 | | DVL2 3 5 | | DVL42 | | DVL12 3 5 | | Dishevelled-1-Like1 | | DVL-221 2 | | DSH Homolog 1-Like3 | | Dishevelled 1-Like 1 (Homologous To Drosophila Dsh)1 | | |
Export aliases for DVL1L1 gene to outside databasesPrevious GC identifers: GC22U990058 GC01M001176 GC01M001310 GC01M001260 GC01M001270 GC22M002861 |
Summaries
for DVL1L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DVL1L_HUMAN, P54792Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes
|
Genomic Views
for DVL1L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DVL1L1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DVL1L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DVL1L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21|22q11 HGNC cytogenetic band: 22q11.21DVL1L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M019240: view genomic region
(about GC identifiers)
Start:
|
19,240,644 bp from pter |
End:
|
19,240,992 bp from pter |
Size:
|
349 bases |
Orientation:
|
minus strand |
|
Proteins
for DVL1L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DVL1L_HUMAN, P54792 (See
protein sequence)Recommended Name: Putative Segment polarity protein dishevelled homolog DVL-1-like Size: 670 amino acids; 73254 Da
Subcellular location: Cytoplasm (Potential)
Miscellaneous: May be involved in the pathogenesis of DiGeorge syndrome (DGS)
Caution: Product of a dubious gene prediction. Pizzuti et al (PubMed:8644734) localize this sequence on chromosome 22but this gene is not present in reference genome assembly on chromosome 22 but on chromosome 1 (GRCh37/hg19). May beinvolved in the pathogenesis of DiGeorge syndrome (DGS)Alternative splicing: 2 isoforms: P54792-1 P54792-2 Explore the universe of human proteins at neXtProt for DVL1L1: NX_P54792
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P54792
DVL1L1 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products for DVL1L1:
DVL1L1 Antibody Products:
Assay Products for DVL1L1: |
Protein
Domains /
Families
for DVL1L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DVL1L1 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry P54792ProtoNet protein and cluster: P54792 4 Blocks protein families: IPB000591 Pleckstrin putative G-protein interacting domain IPB001478 PDZ/DHR/GLGF domain IPB003351 Dishevelled protein IPB008339 Dishevelled protein signature
UniProtKB/Swiss-Prot: DVL1L_HUMAN, P54792Similarity: Belongs to the DSH familySimilarity: Contains 1 DEP domainSimilarity: Contains 1 DIX domainSimilarity: Contains 1 PDZ (DHR) domain |
Function
for DVL1L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DVL1L_HUMAN, P54792Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes Genatlas biochemistry entry for DVL1L1:Drosophila dishevelled segment polarity-like gene homolog,expressed in several fetal and adult tissues,including thymusand heart,deleted in DiGeorge syndrome,activated in WNT signal transduction
Phenotypes:
2 GenomeRNAi human phenotypes for DVL1L1:
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1L1 |
|
Pathways & Interactions
for DVL1L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Androgen Receptor nuclear signaling | | | 2 | Translation_Non-genomic (rapid) action of Androgen Receptor | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  EMD Millipore Pathways for DVL1L1
DVL1L1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DVL1L1
3 Interacting proteins for DVL1L1 (P547922, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DVL1L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DVL1L1
Search CenterWatch for drugs/clinical trials and news about DVL1L1
|
Transcripts
for DVL1L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
GeneLoc Exon Structure
|
Expression
for DVL1L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See DVL1L1 Protein Expression from SPIRE MOPED and PaxDBUniProtKB/Swiss-Prot: DVL1L_HUMAN, P54792Tissue specificity: Expressed in thymus, heart, liver, kidney, brain, skeletal muscle, and pancreas
SABiosciences Custom PCR Arrays for DVL1L1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DVL1L1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DVL1L1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL1L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1L1 |
Orthologs
for DVL1L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
|
Paralogs
for DVL1L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DVL1L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DVL1L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DVL1L1 for disorders About GeneDecksing
OMIM gene information: 601225
OMIM disorders: --
1  disease for DVL1L1: About MalaCardsdigeorge syndrome
Export disorders for DVL1L1 gene to outside databases
|
Publications
for DVL1L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DVL1L1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with DVL1L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human homologue sequences to the Drosophila dishevelled segment- polarity gene are deleted in the DiGeorge syndrome. (PubMed id 8644734)1, 2, 3, 9 Pizzuti A....Dallapiccola B. (1996)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I....O'Brien K.P. (1999)
- cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)1, 9 Pizzuti A.... Dallapiccola B. (1996)
- The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. (PubMed id 12384700)1, 9 Capelluto D.G....Overduin M. (2002)
- Non-canonical Wnt signaling induces ubiquitination an d degradation of Syndecan4. (PubMed id 20639201)1 Carvallo L....LarraA-n J. (2010)
- A coated vesicle-associated kinase of 104 kDa (CVAK10 4) induces lysosomal degradation of frizzled 5 (Fzd5). (PubMed id 19643732)1 Terabayashi T....Miki H. (2009)
- The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. (PubMed id 16604061)1 Funato Y....Miki H. (2006)
- Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)1 Semenov M.V. and Snyder M. (1997)
- PTK7 recruits dsh to regulate neural crest migration. (PubMed id 19004858)9 Shnitsar I. and Borchers A. (2008)
- Dishevelled promotes axon differentiation by regulating atypical protein kinase C. (PubMed id 17558396)9 Zhang X....Luo Z.G. (2007)
|
External Searches for DVL1L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DVL1L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DVL1L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DVL1L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DVL1L1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DVL1L1 gene:
Search GeneIP for patents involving DVL1L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DVL1L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DVL1L1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DVL1L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DVL1L1 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DVL1L1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL1L1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DVL1L1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DVL1L1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DVL1L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1L1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DVL1L1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DVL1L1 |
| |  | |
|
|
|
