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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DVL1 Gene

protein-coding GIFtS: 65
GCID: GC01M001262

dishevelled, dsh homolog 1 (Drosophila)

(Previous name: dishevelled 1 (homologous to Drosophila dsh) )

Explore 29 diseases affiliated with
DVL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dishevelled, Dsh Homolog 1 (Drosophila)¹ ²		DVL1L1²
Dishevelled 1 (Homologous To Drosophila Dsh)¹ ²		Dishevelled-1³
DSH Homolog 1² ³		Segment Polarity Protein Dishevelled Homolog DVL-1²
DVL²		Dishevelled-1³

External Ids:	HGNC: 3084¹	Entrez Gene: 1855²	Ensembl: ENSG00000107404⁷	OMIM: 601365⁵	UniProtKB: O14640³

Export aliases for DVL1 gene to outside databases

Previous GC identifers: GC01M000796 GC01M001021 GC01M001147 GC01M001177 GC01M001178 GC01M001311 GC01M001261

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DVL1:

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates

cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast

specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and

Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may

be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and

transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling.

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon

WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent

regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)

Gene Wiki entry for DVL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004350.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DVL1 gene promoter:
HNF-4alpha2 HNF-4alpha1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DVL1 promoter sequence

Search SABiosciences Chromatin IP Primers for DVL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DVL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36

DVL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001262: view genomic region (about GC identifiers)

Start:	1,270,656 bp from pter	End:	1,284,730 bp from pter
Size:	14,075 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640 (See protein sequence)

Recommended Name: Segment polarity protein dishevelled homolog DVL-1

Size: 695 amino acids; 75187 Da

Subunit: Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS.

Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with

ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ

domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with

DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts (via DEP domain)

with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR

clustering (By similarity)

Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol

(By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with

frizzled family members (By similarity)

Secondary accessions: Q5TA33 Q5TA35

Alternative splicing: 2 isoforms: O14640-1 O14640-2

Explore the universe of human proteins at neXtProt for DVL1: NX_O14640

Post-translational modifications:

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the

ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for

ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity)¹

View modification sites using PhosphoSitePlus² (DVL1)

View neXtProt modification sites for NX_O14640

DVL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004412.2

ENSEMBL proteins:

ENSP00000368169 ENSP00000368166

Human Recombinant Protein Products:

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	Novus Biologicals DVL1 Proteins Novus Biologicals DVL1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DVL1

Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--
GO:0005829	cytosol	IEA	--
GO:0005874	microtubule	IBA	--
GO:0005886	plasma membrane	--	--
GO:0005938	cell cortex	IBA	--

DVL1 for ontologies About GeneDecksing

DVL1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL1
	R&D Systems Antibodies for DVL1 (Dishevelled-1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for DVL1
	GenScript Custom Superior Antibodies Services for DVL1
	Novus Biologicals DVL1 Antibodies
	Search for Antibodies for DVL1 at Abcam
	Uscn Antibodies for DVL1
	ThermoFisher Antibodies for DVL1

Assay Products for DVL1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DVL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DVL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DVL1 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR001478 PDZ

IPR024580 Dishevelled_C-dom

IPR008340 Dishevelled_1

IPR015506 Dsh/Dvl-rel

Graphical View of Domain Structure for InterPro Entry O14640

ProtoNet protein and cluster: O14640

4 Blocks protein families:

IPB000591 Pleckstrin putative G-protein interacting domain

IPB001478 PDZ/DHR/GLGF domain

IPB003351 Dishevelled protein

IPB008339 Dishevelled protein signature

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Domain: The DIX domain promotes homooligomerization (By similarity)

Domain: The DEP domain mediates interaction with the cell membrane (By similarity)

Similarity: Belongs to the DSH family

Similarity: Contains 1 DEP domain

Similarity: Contains 1 DIX domain

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and

transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling.

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon

WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent

regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)

Genatlas biochemistry entry for DVL1:

Drosophila dishevelled segment polarity gene homolog 1,widely expressed,putatively involved in neural and heart

development,activated in WNT signal transduction,frequently but not always deleted in the 1PDEL syndrome,most likely

not contributing to the syndrome

miRNA Products:		OriGene 3'-UTR Clone: DVL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DVL1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL1:
		hsa-miR-3163 hsa-miR-466 hsa-miR-4255 hsa-miR-139-5p hsa-miR-4282 hsa-miR-3941 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: DVL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DVL1 (see all 7) OriGene shRNA RFP: DVL1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DVL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DVL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DVL1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DVL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DVL1 (NM_004421)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0004871	signal transducer activity	IEA	--
GO:0005109	frizzled binding	IPI	19388021
GO:0005515	protein binding	IPI	--
GO:0019899	enzyme binding	IPI	19643732

DVL1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Dvl1^tm1Awb for DVL1
     8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dvl1):

behavior/neurological	cardiovascular system	embryogenesis	hearing/vestibular/ear	mortality/aging
nervous system	normal	skeleton

DVL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35	Wnt Signaling Pathway NetPath	0.22

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DVL1

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for DVL1

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DVL1 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Reelin Pathway (Cajal-Retzius cells)

2 GeneGo (Thomson Reuters) Pathways for DVL1

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/12 BioSystems Pathways for DVL1 (see all 12)

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Neural Crest Differentiation
	Adipogenesis
	DNA damage response (only ATM dependent)

5 Kegg Pathways (Kegg details for DVL1):

	Wnt signaling pathway
	Notch signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

DVL1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DVL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/166 Interacting proteins for DVL1 (O14640^{2, 3} ENSP00000368169⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 166)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APC	P25054²^,³, ENSP00000257430⁴	MINT-7897032 MINT-7897055 MINT-7897075 MINT-7897100 I2D: score=1 STRING: ENSP00000257430
DAAM1	Q9Y4D1²^,³, ENSP00000247170⁴	MINT-8379834 MINT-8379825 I2D: score=2 STRING: ENSP00000247170
USP13	Q92995²^,³	MINT-65081 I2D: score=5
ANXA7	P20073²^,³	MINT-8248285 I2D: score=2
DVL2	O14641²^,³, ENSP00000005340⁴	MINT-7897032 MINT-7897075 I2D: score=4 STRING: ENSP00000005340

About this table

Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001505	regulation of neurotransmitter levels	ISS	--
GO:0001932	regulation of protein phosphorylation	--	--
GO:0001933	negative regulation of protein phosphorylation	--	--
GO:0006366	transcription from RNA polymerase II promoter	IDA	11742073
GO:0006469	negative regulation of protein kinase activity	IDA	10330181

DVL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DVL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DVL1
2 Novoseek chemical compound relationships for DVL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	62	6	10617280 (1), 10944533 (1), 10647780 (1), 11742073 (1) (see all 5)
h2o2	0	1	15279902 (1)

Search CenterWatch for drugs/clinical trials and news about DVL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DVL1 gene (3 alternative transcripts):

NM_004421.2 NM_181870.1 NM_182779.3

Unigene Cluster for DVL1:

Dishevelled, dsh homolog 1 (Drosophila)

Hs.731450 [show with all ESTs]

Unigene Representative Sequence: NM_004421

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378891(uc009vka.3 uc001aer.4) ENST00000378888(uc002quu.3 uc001aeu.1)

ENST00000472445

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate DVL1:
		hsa-miR-3163 hsa-miR-466 hsa-miR-4255 hsa-miR-139-5p hsa-miR-4282 hsa-miR-3941 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: DVL1 3' UTR sequence

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DVL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL1

Additional cDNA sequence:

AF006011.1 AK093189.1 AK293286.1 AK300063.1 BC017225.2 BC025292.1 BC050454.1 BC111419.1

11 DOTS entries:

DT.113126 DT.92435722 DT.92435732 DT.100820977 DT.100673315 DT.95199508 DT.95199483 DT.100820980

DT.91879999 DT.100820983 DT.100820981

24/204 AceView cDNA sequences (see all 204):

CF132269 BM847934 BM847184 AL045022 AA653425 BE618057 AK093189 CD674627

AJ346388 BU178594 AA827635 AW262005 AI828993 BQ269582 BM713331 AA576965

BQ216870 AA628314 BM549186 AA993348 AX747980 CA771237 BQ063137 BM844463

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DVL1 (see all 10) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^
SP1:																	-																				-		-												-
SP2:																	-
SP3:																																																			-
SP4:																	-
SP5:															-		-		-		-		-		-		-		-		-		-		-		-		-		-		-								-

ExUns:	16	^	17a	·	17b
SP1:	-
SP2:
SP3:	-
SP4:
SP5:	-

ECgene alternative splicing isoforms for DVL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DVL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCGCAGGG

About this image

DVL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Neural Tube

Neural Tube

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DVL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DVL1

SOURCE GeneReport for Unigene cluster: Hs.731450

SABiosciences Expression via Pathway-Focused PCR Arrays including DVL1:

Primary Cilia in human mouse rat

WNT Signaling Pathway in human mouse rat

Notch Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DVL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DVL1
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DVL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DVL1 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DVL1¹	dishevelled, dsh homolog 1 (Drosophila)	74.26(n) 83.93(a)		419416 XM_003642523.1 XP_003642571.1
lizard (Anolis carolinensis)	Reptilia	DVL1⁶ --	--	76(a) 36(a)	1 ↔ 1 possible ortholog	GL343760.1(4475-60602) AAWZ02041057(3290-5409)
zebrafish (Danio rerio)	Actinopterygii	dvl1b¹	dishevelled, dsh homolog 1b (Drosophila)	67.27(n) 73.79(a)		560032 NM_001044917.1 NP_001038382.1
fruit fly (Drosophila melanogaster)	Insecta	dsh³	cell motility Notch binding	64(a)		--
worm (Caenorhabditis elegans)	Secernentea	T05C12.6c³	presynaptic density protein (PSD-95) repeat-like domain less	29(a)		II(8182431-8184930) --

ENSEMBL Gene Tree for DVL1 (if available)
TreeFam Gene Tree for DVL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DVL1 gene

DVL2² DVL3²

5 SIMAP similar genes for DVL1 using alignment to 3 protein entries: DVL1_HUMAN (see all proteins):

DVL1L1 DKFZp586M1622 DVL3 DLG4 DVL2

DVL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146644070^1,2		--	1270217(+)	`CTGCCA/GACCTG`	1	--	ds500¹		0	--	--	--	--
rs141342516^1,2		--	1270251(+)	`TCCTGC/TACCCT`	1	--	ds500¹		0	--	--	--	--
rs143814811^1,2		--	1270253(+)	`CTGCAC/TCCTGC`	1	--	ds500¹		0	--	--	--	--
rs188647^1,2	C,	--	1270329(+)	`GAGGTG/AGGGGT`	1	--	ds500¹		7		NA WA CSA	14
rs307374^1,2	C,	--	1270359(+)	`TGCCCC/TTTGCC`	1	--	ds500¹		9		MN NA WA CSA	199
rs11488701^1,2		--	1270453(+)	`AGCACT/CGACCA`	1	--	ds500¹		1		NA	2
rs189725006^1,2		--	1270509(+)	`GATCTG/TACGCC`	1	--	ds500¹		0	--	--	--	--
rs138140323^1,2		--	1270629(+)	`CAGCCA/GGAGAG`	1	--	ds500¹		0	--	--	--	--
rs192439261^1,2		--	1270651(+)	`GCCACA/GCATCT`	1	--	ds500¹		0	--	--	--	--
rs183730592^1,2		--	1270737(+)	`TAAACA/GCTGGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DVL1 (1270656 - 1284730 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DVL1
3 CNVs: 0001 3275 30362

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing DVL1:

WNT Signaling

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DVL1

DNA2.0 Custom Variant and Variant Library Synthesis for DVL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DVL1 for disorders           About GeneDecksing

OMIM gene information: 601365    OMIM disorders: --

20/29 diseases for DVL1 (see all 29):    About MalaCards

charcot-marie-tooth disease charcot-marie-tooth disease type 2 charcot-marie-tooth disease type 2a schwartz-jampel syndrome

tooth disease double outlet right ventricle dentatorubral-pallidoluysian atrophy familial adenomatous polyposis

neural tube defect adenomatous polyposis coli cervical squamous cell carcinoma squamous cell carcinoma

polyposis basal cell carcinoma digeorge syndrome nephronophthisis

cervicitis breast cancer colon carcinoma carcinoma

5 Novoseek disease relationships for DVL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis	71.7	6	10617280 (1), 11818547 (1), 10944533 (1), 18662704 (1) (see all 5)
cancer	25.8	2	12824876 (1), 12883684 (1)
tumors	13.8	2	19576519 (1), 12824876 (1)
cervical cancer	9.73	1	16457155 (1)
breast cancer	0	2	12824876 (2)

Genetic Association Database (GAD): DVL1
Human Genome Epidemiology (HuGE) Navigator: DVL1 (4 documents)

Export disorders for DVL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DVL1 gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with DVL1)

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world of online information

Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. (PubMed id 11803455)^{1, 4, 9} Russ C....Powell J.F. (2002)
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. (PubMed id 11742073)^{1, 2, 9} Chen W.... Miller W.E. (2001)
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. (PubMed id 15852005)^{1, 2} Simons M.... Walz G. (2005)
Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. (PubMed id 15454084)^{1, 2} Lu W....Baltimore D. (2004)
Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway. (PubMed id 14750955)^{1, 2} Oshita A.... Kikuchi A. (2003)
Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)^{1, 2} Semenov M.V. and Snyder M. (1997)
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)^{1, 3} Pizzuti A.... Dallapiccola B. (1996)
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. (PubMed id 18093802)^{1, 9} Lee Y.N....Wang H.Y. (2008)
Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer. (PubMed id 16457155)^{1, 9} Mizutani K....Onda M. (2005)
Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PubMed id 12556519)^{1, 9} Hino S.... Kikuchi A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1855	HGNC: 3084	AceView: DVL1	Ensembl:ENSG00000107404	euGenes: HUgn1855
ECgene: DVL1	Kegg: 1855	H-InvDB: DVL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DVL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DVL1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DVL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DVL1 gene:
Search GeneIP for patents involving DVL1

GeneCards and IP:
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dishevelled, dsh homolog 1 (Drosophila)

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DVL1 Gene

dishevelled, dsh homolog 1 (Drosophila)

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