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DVL1 Gene

protein-coding GIFtS: 65
GCID: GC01M001262

Dishevelled Segment Polarity Protein 1

(Previous names: dishevelled 1 (homologous to Drosophila dsh), dishevelled,...)

See DVL1-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Dishevelled Segment Polarity Protein 1¹ ²		DVL1P1²
Dishevelled 1 (Homologous To Drosophila Dsh)¹ ²		Dishevelled, Dsh Homolog 1²
DSH Homolog 1² ³		dishevelled-1²
Dishevelled, Dsh Homolog 1 (Drosophila)¹		Segment Polarity Protein Dishevelled Homolog DVL-1²
DVL²		Dishevelled-1³
DVL1L1²

External Ids:	HGNC: 3084¹	Entrez Gene: 1855²	Ensembl: ENSG00000107404⁷	OMIM: 601365⁵	UniProtKB: O14640³

Export aliases for DVL1 gene to outside databases

Previous GC identifers: GC01M000796 GC01M001021 GC01M001147 GC01M001177 GC01M001178 GC01M001311 GC01M001261

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DVL1 Gene:

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that

regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation

and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel

syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of

these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene

during development. (provided by RefSeq, Jul 2008)

GeneCards Summary for DVL1 Gene:

DVL1 (dishevelled segment polarity protein 1) is a protein-coding gene. Diseases associated with DVL1 include charcot-marie-tooth disease type 2a, and dentatorubral-pallidoluysian atrophy. GO annotations related to this gene include identical protein binding and signal transducer activity. An important paralog of this gene is DVL2.

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and

transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt

signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1

activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for

MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)

Gene Wiki entry for DVL1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the DVL1 gene promoter:
HNF-4alpha2 HNF-4alpha1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DVL1 promoter sequence

Search Chromatin IP Primers for DVL1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DVL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36

DVL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DVL1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001262: view genomic region (about GC identifiers)

Start:	1,270,656 bp from pter	End:	1,284,730 bp from pter
Size:	14,075 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640 (See protein sequence)

Recommended Name: Segment polarity protein dishevelled homolog DVL-1

Size: 695 amino acids; 75187 Da

Subunit: Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS.

Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with

ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts

(via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ

domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts

(via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary

complex involved in AChR clustering (By similarity). Interacts (via PDZ domain) with TMEM88

Secondary accessions: Q5TA33 Q5TA35

Alternative splicing: 2 isoforms: O14640-1 O14640-2

Explore the universe of human proteins at neXtProt for DVL1: NX_O14640

Explore proteomics data for DVL1 at MOPED

Post-translational modifications:

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the

ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for

ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity)¹

Ubiquitination² at Lys285

Modification sites at PhosphoSitePlus (DVL1)

See DVL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004412.2

ENSEMBL proteins:

ENSP00000368169 ENSP00000368166

Reactome Protein details: O14640

DVL1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for DVL1 OriGene Custom MassSpec OriGene Custom Protein Services for DVL1
	GenScript Custom Purified and Recombinant Proteins Services for DVL1
	Novus Biologicals DVL1 Proteins Novus Biologicals DVL1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DVL1
	Search eBioscience for Proteins for DVL1
	antibodies-online proteins for DVL1 (7 products)
	antibodies-online peptides for DVL1

DVL1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DVL1
	R&D Systems Antibodies for DVL1 (Dishevelled-1)
	OriGene Antibodies for DVL1 OriGene Custom Antibody Services for DVL1
	Novus Biologicals DVL1 Antibodies
	Abcam antibodies for DVL1
	Cloud-Clone Corp. Antibodies for DVL1
	ThermoFisher Antibodies for DVL1
	antibodies-online antibodies for DVL1 (38 products)

DVL1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DVL1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DVL1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DVL1 Cloud-Clone Corp. CLIAs for DVL1
	Search eBioscience for ELISAs for DVL1
	antibodies-online kits for DVL1 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

DVL: Dishevelled homologs

Selected InterPro protein domains (see all 9):

IPR011991 WHTH_DNA-bd_dom

IPR001478 PDZ

IPR024580 Dishevelled_C-dom

IPR008340 Dishevelled_1

IPR015506 Dsh/Dvl-rel

Graphical View of Domain Structure for InterPro Entry O14640

ProtoNet protein and cluster: O14640

4 Blocks protein domains:

IPB000591 Pleckstrin putative G-protein interacting domain

IPB001478 PDZ/DHR/GLGF domain

IPB003351 Dishevelled protein

IPB008339 Dishevelled protein signature

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Domain: The DIX domain promotes homooligomerization (By similarity)

Domain: The DEP domain mediates interaction with the cell membrane (By similarity)

Similarity: Belongs to the DSH family

Similarity: Contains 1 DEP domain

Similarity: Contains 1 DIX domain

Similarity: Contains 1 PDZ (DHR) domain

Find genes that share domains with DVL1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DVL1_HUMAN, O14640

Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and

transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt

signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1

activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for

MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)

Genatlas biochemistry entry for DVL1:

Drosophila dishevelled segment polarity gene homolog 1,widely expressed,putatively involved in neural and heart

development,activated in WNT signal transduction,frequently but not always deleted in the 1PDEL syndrome,most

likely not contributing to the syndrome

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0004871	signal transducer activity	IEA	--
GO:0005109	frizzled binding	IPI	19388021
GO:0005515	protein binding	IPI	10330181
GO:0019899	enzyme binding	IPI	15454084

Find genes that share ontologies with DVL1 About GenesLikeMe

Phenotypes:
8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dvl1):

behavior/neurological	cardiovascular system	embryogenesis	hearing/vestibular/ear	mortality/aging
nervous system	normal	skeleton

Find genes that share phenotypes with DVL1 About GenesLikeMe

Animal Models:
MGI mouse knock-out Dvl1^tm1Awb for DVL1

genOway: Develop your customized and physiologically relevant rodent model for DVL1

miRNA Products:		miRTarBase miRNAs that target DVL1: hsa-mir-378a-3p (MIRT043927), hsa-mir-10a-5p (MIRT047691), hsa-mir-744-5p (MIRT037606)

		Block miRNA regulation of human, mouse, rat DVL1 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate DVL1:
		hsa-miR-3163 hsa-miR-466 hsa-miR-4255 hsa-miR-139-5p hsa-miR-4282 hsa-miR-3941 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: DVL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DVL1
		Predesigned siRNA for gene silencing in human, mouse, rat DVL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DVL1

Clone Products:		OriGene clones in human, mouse for DVL1 (see all 12) OriGene ORF clones in mouse, rat for DVL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DVL1 (NM_004421)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DVL1
		Browse ESI BIO Cell Lines and PureStem Progenitors for DVL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-12151) for DVL1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DVL1_HUMAN, O14640: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm,

cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon

interaction with frizzled family members (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
cytoskeleton	3
cytosol	3
nucleus	3

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Gene Ontology (GO): Selected cellular component terms (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IEA	--
GO:0005874	microtubule	IBA	--
GO:0005938	cell cortex	IBA	--

Find genes that share ontologies with DVL1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DVL1 About (see all 28)

See pathways by source

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SuperPath

Contained pathways About

Wnt signaling pathway (KEGG)

	Wnt signaling pathway	0.40			Wnt Signaling Pathway NetPath	0.37
	Wnt Signaling Pathways	0.40

Notch signaling pathway (KEGG)

Notch signaling pathway

0.84

Notch Signaling Pathway

0.84

Wnt Signaling Pathway (WikiPathways)

	Wnt Signaling Pathway	0.55			DNA damage response (only ATM dependent)	0.32
	Wnt Signaling Pathway and Pluripotency	0.55

beta-catenin independent WNT signaling

beta-catenin independent WNT signaling

0.79

Signaling by Wnt

0.79

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

0.61

GSK3 Signaling

0.61

Find genes that share SuperPaths with DVL1 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for DVL1

Wnt Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DVL1 (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Reelin Pathway (Cajal-Retzius cells)

2 GeneGo (Thomson Reuters) Pathways for DVL1

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

Selected BioSystems Pathways for DVL1 (see all 13)

	MicroRNAs in cardiomyocyte hypertrophy
	Wnt Signaling Pathway
	Adipogenesis
	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)

5 Reactome Pathways for DVL1

	degradation of DVL
	WNT mediated activation of DVL
	disassembly of the destruction complex and recruitment of AXIN to the membrane
	PCP/CE pathway
	TCF dependent signaling in response to WNT

Selected Kegg Pathways (Kegg details for DVL1) (see all 7):

	Wnt signaling pathway
	Notch signaling pathway
	Hippo signaling pathway
	Melanogenesis
	HTLV-I infection

Pathway & Disease-focused RT² Profiler PCR Arrays including DVL1:

Primary Cilia in human mouse rat

WNT Signaling Pathway in human mouse rat

Notch Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

Interactions:

GeneGlobe Interaction Network for DVL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DVL1 (O14640^{1, 2, 3} ENSP00000368169⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 323)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APC	P25054¹^,²^,³, ENSP00000257430⁴	EBI-723489,EBI-727707 MINT-7897032 MINT-7897055 MINT-7897075 MINT-7897100 I2D: score=1 STRING: ENSP00000257430
DAAM1	Q9Y4D1²^,³, ENSP00000247170⁴	MINT-8379834 MINT-8379825 I2D: score=2 STRING: ENSP00000247170
TFDP1	Q14186¹^,²	EBI-723489,EBI-749713 MINT-8404114 MINT-8404100 MINT-8404082
USP13	Q92995²^,³	MINT-65081 I2D: score=5
ANXA7	P20073²^,³	MINT-8248285 I2D: score=2

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Gene Ontology (GO): Selected biological process terms (see all 38): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001505	regulation of neurotransmitter levels	ISS	--
GO:0001932	regulation of protein phosphorylation	--	--
GO:0001933	negative regulation of protein phosphorylation	--	--
GO:0006366	transcription from RNA polymerase II promoter	IDA	11742073
GO:0006469	negative regulation of protein kinase activity	IDA	10330181

Find genes that share ontologies with DVL1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DVL1

2 Novoseek inferred chemical compound relationships for DVL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	62	6	10617280 (1), 10944533 (1), 10647780 (1), 11742073 (1) (see all 5)
h2o2	0	1	15279902 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DVL1 gene (3 alternative transcripts):

NM_004421.2 NM_181870.1 NM_182779.3

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378891(uc009vka.3 uc001aer.4) ENST00000378888(uc002quu.3 uc001aeu.1)

ENST00000472445

miRNA Products:		Block miRNA regulation of human, mouse, rat DVL1 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate DVL1:
		hsa-miR-3163 hsa-miR-466 hsa-miR-4255 hsa-miR-139-5p hsa-miR-4282 hsa-miR-3941 hsa-miR-646
		SwitchGear 3'UTR luciferase reporter plasmid: DVL1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DVL1
		Predesigned siRNA for gene silencing in human, mouse, rat DVL1

Clone Products:		OriGene clones in human, mouse for DVL1 (see all 12) OriGene ORF clones in mouse, rat for DVL1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DVL1 (NM_004421)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DVL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DVL1

Primer Products:		OriGene qPCR primer pairs and template standards for DVL1 OriGene qSTAR qPCR primer pairs in human, mouse for DVL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DVL1
		QuantiTect SYBR Green Assays in human, mouse, rat DVL1
		QuantiFast Probe-based Assays in human, mouse, rat DVL1

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-12151) for DVL1

Selected AceView cDNA sequences (see all 204):

AI828993 BU181644 AJ346388 AA993348 BQ083047 NM_181870 CD674627 AI567536

AA576965 BM544722 AA653425 AL045022 BM847184 AI624002 BM549186 BE502662

AK093189 BM844463 AA628314 BC017225 BQ269582 CR616573 BE618057 AA693493

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DVL1 (see all 10) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^
SP1:																	-																				-		-												-
SP2:																	-
SP3:																																																			-
SP4:																	-
SP5:															-		-		-		-		-		-		-		-		-		-		-		-		-		-		-								-

ExUns:	16	^	17a	·	17b
SP1:	-
SP2:
SP3:	-
SP4:
SP5:	-

ECgene alternative splicing isoforms for DVL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DVL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCCGCAGGG

About this image

DVL1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 9) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Neural Tube (Nervous System) fully expand to see all 2 entries
Telencephalon

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Testis (Reproductive System)
Leydig Cells Testis Interstitium

DVL1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DVL1 Protein Expression

Pathway & Disease-focused RT² Profiler PCR Arrays including DVL1:

Primary Cilia in human mouse rat

WNT Signaling Pathway in human mouse rat

Notch Signaling Pathway in human mouse rat

Stem Cells in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for DVL1 OriGene qSTAR qPCR primer pairs in human, mouse for DVL1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DVL1
		QuantiTect SYBR Green Assays in human, mouse, rat DVL1
		QuantiFast Probe-based Assays in human, mouse, rat DVL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DVL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DVL1 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dvl1^{1 , 5}	dishevelled, dsh homolog 1 (Drosophila)^{1, 5}	87.29(n)¹ 94.92(a)¹		4 (87.61 cM)⁵ 13542¹ NM_010091.3¹ NP_034221.3¹ 155847402⁵
chicken (Gallus gallus)	Aves	DVL1¹	dishevelled, dsh homolog 1 (Drosophila)	73.72(n) 82.95(a)		419416 XM_004947409.1 XP_004947466.1
lizard (Anolis carolinensis)	Reptilia	DVL1⁶	dishevelled segment polarity protein 1	77(a)	1 ↔ 1	GL343760.1(4475-60602)
tropical clawed frog (Xenopus tropicalis)	Amphibia	dvl1¹	dishevelled segment polarity protein 1	73.46(n) 86.24(a)		100144639 NM_001123414.1 NP_001116886.1
zebrafish (Danio rerio)	Actinopterygii	dvl1b¹	dishevelled, dsh homolog 1b (Drosophila)	67.23(n) 72.94(a)		560032 NM_001044917.1 NP_001038382.1
fruit fly (Drosophila melanogaster)	Insecta	dsh³	cell motility Notch binding	64(a)		--
worm (Caenorhabditis elegans)	Secernentea	T05C12.6c³	presynaptic density protein (PSD-95) repeat-like domain less	29(a)		II(8182431-8184930) --

ENSEMBL Gene Tree for DVL1 (if available)
TreeFam Gene Tree for DVL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DVL1 gene

DVL2² DVL3² DIXDC1²

5 SIMAP similar genes for DVL1 using alignment to 3 protein entries: DVL1_HUMAN (see all proteins):

DVL1P1 DVL3 DKFZp586M1622 DLG4 DVL2

Find genes that share paralogs with DVL1 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35915703^1,2	C,F	--	1269467(-)	`TGCCCG/CGTCCA`	1	--	us2k¹		1		NA	2
rs192910940^1,2		--	1269507(+)	`TGGACC/GGGGCA`	1	--	us2k¹		0	--	--	--	--
rs184571809^1,2		--	1269520(+)	`AGCGAC/TGGGGG`	1	--	us2k¹		0	--	--	--	--
rs113488343^1,2	F	--	1269552(+)	`GGGGCT/AGGAGC`	1	--	us2k¹		1		CSA	1
rs180738781^1,2		--	1269559(+)	`GAGCGA/GCGGGG`	1	--	us2k¹		0	--	--	--	--
rs35104845^1,2	C,F	--	1269560(-)	`CCCCCA/GTCGCT`	1	--	us2k¹		2		NA	4
rs61766214^1,2	C	--	1269587(+)	`TGGACC/GGGGCT`	1	--	us2k¹		4		NA	8
rs34380086^1,2	C	--	1269663(-)	`GATGCG/CAGTTC`	1	--	us2k¹		11		NA WA CSA EA	373
rs307379^1,2	C	--	1269733(+)	`GCACCG/AGTGCT`	1	--	us2k¹		10		NA EA WA CSA	265
rs144305273^1,2		--	1269777(+)	`GCACCC/GGGGCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DVL1 (1270656 - 1284730 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for DVL1 (see all 26): About this table

Variant ID	Type	Subtype	PubMed ID
esv2746363	CNV	Deletion	23290073
dgv17n71	CNV	Loss	21882294
nsv470680	CNV	Loss	18288195
nsv870639	CNV	Loss	21882294
dgv29n71	CNV	Loss	21882294
nsv482937	CNV	Loss	15286789
dgv39n71	CNV	Loss	21882294
dgv12n71	CNV	Loss	21882294
dgv25n71	CNV	Loss	21882294
dgv19n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): DVL1

Site Specific Mutation Identification with PCR Assays

1 Copy Number PCR Panel containing DVL1:

WNT Signaling

SeqTarget long-range PCR primers for resequencing DVL1

DNA2.0 Custom Variant and Variant Library Synthesis for DVL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601365 OMIM disorders: --

5 diseases for DVL1:
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charcot-marie-tooth disease type 2a dentatorubral-pallidoluysian atrophy familial adenomatous polyposis charcot-marie-tooth disease type 2

charcot-marie-tooth disease

Find genes that share disorders with DVL1 About GenesLikeMe

5 Novoseek inferred disease relationships for DVL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis	71.7	6	10617280 (1), 11818547 (1), 10944533 (1), 18662704 (1) (see all 5)
cancer	25.8	2	12824876 (1), 12883684 (1)
tumors	13.8	2	19576519 (1), 12824876 (1)
cervical cancer	9.73	1	16457155 (1)
breast cancer	0	2	12824876 (2)

Genetic Association Database (GAD): DVL1
Human Genome Epidemiology (HuGE) Navigator: DVL1 (4 documents)

Export disorders for DVL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DVL1 gene, integrated from 10 sources (see all 109):
(articles sorted by number of sources associating them with DVL1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. (PubMed id 11803455)^{1, 4, 9} Russ C....Powell J.F. (Mol. Psychiatry 2002)
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. (PubMed id 11742073)^{1, 2, 9} Chen W.... Miller W.E. (Proc. Natl. Acad. Sci. U.S.A. 2001)
Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. (PubMed id 21044957)^{1, 2} Lee H.J....Zheng J.J. (J. Biol. Chem. 2010)
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)^{1, 4} Jugessur A....Murray J.C. (PLoS ONE 2010)
High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)^{1, 4} Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. (PubMed id 15852005)^{1, 2} Simons M.... Walz G. (Nat. Genet. 2005)
Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. (PubMed id 15454084)^{1, 2} Lu W.... Baltimore D. (Cell 2004)
Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway. (PubMed id 14750955)^{1, 2} Oshita A.... Kikuchi A. (Genes Cells 2003)
Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)^{1, 2} Semenov M.V. and Snyder M. (Genomics 1997)
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)^{1, 3} Pizzuti A.... Dallapiccola B. (Hum. Mol. Genet. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1855	HGNC: 3084	AceView: DVL1	Ensembl:ENSG00000107404	euGenes: HUgn1855
ECgene: DVL1	Kegg: 1855	H-InvDB: DVL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DVL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DVL1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DVL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DVL1 gene:
Search GeneIP for patents involving DVL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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DVL1 Gene

Dishevelled Segment Polarity Protein 1

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DVL1 Gene

Dishevelled Segment Polarity Protein 1

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