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DVL1 Gene

protein-coding GIFtS: 69

GC01M001261

dishevelled, dsh homolog 1 (Drosophila)
(Previous name: dishevelled 1 (homologous to Drosophila dsh) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DVL ^²
Dishevelled-1 ^³
MGC54245 ^²
OTTHUMP00000003104 ^²

Descriptions
DSH homolog 1 ^³
dishevelled 1 ^²
dishevelled 1 (homologous to Drosophila dsh) ^¹, ²
dishevelled, dsh homolog 1 (Drosophila) ^²

External Ids
HGNC: 3084¹
Entrez Gene: 1855²
UniProtKB: O14640³
Ensembl: ENSG00000107404⁷

Search outside databases for aliases for DVL1 gene

Previous GC identifers: GC01M000796 GC01M001021 GC01M001147 GC01M001177 GC01M001178 GC01M001311

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DVL1:

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic

phosphoprotein that regulates cell proliferation, acting as a transducer molecule for

developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate

gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth

disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may

be consistent with defects which might be expected from aberrant expression of a DVL gene during

development. [provided by RefSeq]

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Gene Wiki entry for DVL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DVL1 gene

Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36

DVL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001261: (about GC identifiers)

Start:	1,260,521 bp from pter
End:	1,274,623 bp from pter
Size:	14,103 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004350.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640 (See protein sequence)

Recommended Name: Segment polarity protein dishevelled homolog DVL-1

Size: 695 amino acids; 75187 Da

Subunit: Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with

BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and

CCDC88C/DAPLE

Subcellular location: Cytoplasm (Potential)

Secondary accessions: Q5TA33 Q5TA35

Alternative splicing: 2 isoforms: O14640-1 O14640-2

Post-translational modifications:

Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction

with INVS is required for ubiquitination¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004412.2 NP_877580.1

ENSEMBL proteins:

ENSP00000368169 ENSP00000368166 ENSP00000340031 ENSP00000263743

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Dishevelled / Dvl1)
	Human Recombinant Proteins from Abnova (DVL1)

OriGene Purified Recombinant Human Protein: DVL1

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	NAS	--
GO:0016023	cytoplasmic membrane-bounded vesicle	ISS	--
GO:0019717	synaptosome	ISS	--
GO:0045202	synapse	ISS	--

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Antibodies for DVL1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of DVL1
	Sigma-Aldrich Antibodies for DVL1
	R&D Systems Antibodies for DVL1 (Dishevelled-1)
	Antibodies from Abcam (Dishevelled / Dvl1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DVL1)
	Novus Biologicals Antibodies for DVL1

Assays for DVL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O14640

ProtoNet protein and cluster: O14640

4 Blocks protein families:

IPB000591 Pleckstrin putative G-protein interacting domain

IPB001478 PDZ/DHR/GLGF domain

IPB003351 Dishevelled protein

IPB008339 Dishevelled protein signature

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Similarity: Belongs to the DSH family

Similarity: Contains 1 DEP domain

Similarity: Contains 1 DIX domain

Similarity: Contains 1 PDZ (DHR) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DVL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DVL1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_181870

Applied Biosystems Silencer® siRNAs for DVL1

Sigma-Aldrich siRNA for DVL1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DVL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004421
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004421
untagged cDNA clones in CMV expression vector (see all 3): NM_004421

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004421

UniProtKB/Swiss-Prot: DVL1_HUMAN, O14640

Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes

Genatlas biochemistry entry for DVL1:

Drosophila dishevelled segment polarity gene homolog 1,widely expressed,putatively involved in

neural and heart development,activated in WNT signal transduction,frequently but not always

deleted in the 1PDEL syndrome,most likely not contributing to the syndrome

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dvl1):

	behavior/neurological	embryogenesis	hearing/vestibular/ear	lethality-prenatal/perinatal
life span-post-weaning/aging	nervous system	normal	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0042802	identical protein binding	IPI	10330181

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for DVL1 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Basal Cell Carcinoma Signaling
Agrin Interactions at Neuromuscular Junction
Molecular Mechanisms of Cancer
Human Embryonic Stem Cell Pluripotency
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency

GeneDecks DVL1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DVL1

5/96 Interacting proteins for DVL1 (ENSP00000368166³ O14640²) via UniProtKB, MINT, and/or STRING (see all 96 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGEF19	Q8IW93²	MINT-6504080
USP13	Q92995²	MINT-65081
CTNNB1	ENSP00000344456³	STRING (score=.999)
DAAM1	ENSP00000247170³	STRING (score=.998)
WNT1	ENSP00000293549³	STRING (score=.996)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006469	negative regulation of protein kinase activity	IDA	10330181
GO:0007242	intracellular signaling cascade	IEA	--
GO:0007269	neurotransmitter secretion	ISS	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007507	heart development	NAS	8644734

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DVL1
1 Novoseek chemical compound relationship for DVL1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	63.87	6	10617280 (1), 10944533 (1), 10647780 (1), 11742073 (1) (see all 5)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DVL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DVL1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_181870

Sigma-Aldrich siRNA for DVL1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004421

REFSEQ mRNAs for DVL1 gene (2 alternative transcripts):

NM_004421.2 NM_182779.3

NM_004421

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004421
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004421
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_004421

Additional cDNA sequence:

AF006011.1 AK093189.1 AK293286.1 AK300063.1 BC017225.2 BC025292.1 BC050454.1 BC111419.1

CR616573.1

11 DOTS entries:

DT.113126 DT.92435722 DT.92435732 DT.100673315 DT.100820977 DT.95199508 DT.95199483 DT.100820980

DT.91879999 DT.100820981 DT.100820983

24/204 AceView cDNA sequences (see all 204 ):

BQ269582 BQ083047 NM_181870 AJ346388 AW262005 CA771237 AA576965 BM791705

BQ960538 BM847184 BQ962704 BM549186 F37827 AA993348 BC017225 CF132269

BM847934 AL045022 AA693493 AI828993 AA653425 CD674627 BQ216870 BM544722

highest scoring ESTs for DVL1:

AA587414 AA628314 AA858244 AF006011 AI828993 AJ346388 AK093189 AK095867 AL045022 AL046253

Unigene Cluster for DVL1:

Dishevelled, dsh homolog 1 (Drosophila)

Hs.719085 [show with all ESTs]

Unigene Representative Sequence: NM_004421

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DVL1 (see all 10 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^
SP1:																	-																				-		-												-
SP2:																	-
SP3:																																																			-
SP4:																	-
SP5:															-		-		-		-		-		-		-		-		-		-		-		-		-		-		-								-

ExUns:	16	^	17a	·	17b
SP1:	-
SP2:
SP3:	-
SP4:
SP5:	-

About this scheme

ECgene alternative splicing isoforms for DVL1

4 Ensembl transcripts including schematic representations:

ENST00000378891 ENST00000378888 ENST00000345100 ENST00000263743

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DVL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DVL1

¹ / ² / ³

6 probe-sets matching DVL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45360_s_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.14	AI990838	0.80	0.70	0.75	1
64927_at²^{, 3}	U95-C	1	1.00	1.00	0.93	1.10	AL043681	0.40	0.50	0.45	1
43392_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.09	AW003613	0.80	0.70	0.75	1
163_at²^{, 3}	U95-A	2	1.00	0.59	0.92	0.68	U46461	0.60	1.00	0.82	1
203230_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF006011	0.60	1.00	0.82	1
203230_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DVL1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACAGAAAAC

SOURCE GeneReport for Unigene cluster: Hs.719085
Expression variation in blood from EXPOLDB for DVL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for DVL1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DVL1¹	--	dishevelled, dsh homolog 1 (Drosophila)	88.51(n) 95.67(a)	489593 XM_546713.2 XP_546713.2
chimpanzee (Pan troglodytes)	DVL1¹	--	dishevelled, dsh homolog 1 (Drosophila)	99.1(n) 99.85(a)	457191 NM_001012430.1 NP_001012432.1
cow (Bos taurus)	DVL1¹	--	dishevelled, dsh homolog 1 (Drosophila)	89.25(n) 94.63(a)	523325 XM_601621.3 XP_601621.3
rat (Rattus norvegicus)	Dvl1¹	--	dishevelled, dsh homolog 1 (Drosophila)	87.54(n) 95.07(a)	83721 NM_031820.1 NP_114008.1
mouse (Mus musculus)	Dvl1^{1, 5}	4 (82.00 cM)⁵	dishevelled, dsh homolog 1 (Drosophila)^{1, 5}	87.29(n)¹ 94.92(a)¹	13542¹ NM_010091.3¹ NP_034221.3¹ AK155349⁵ AK162430⁵ (see all 17)

About this table Species with no ortholog for DVL1

ENSEMBL Gene Tree for DVL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DVL1 gene

DVL2² ENSG00000215737² DVL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/75 NCBI SNPs in DVL1 are shown (see all 75 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 9)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11583882^1,2	C	1264670(+)	`TGGGCC/GGCACC`	1	R/P	mis¹ ese³		0	--	--	--	--
--	rs307374^1,2	F	1260222(+)	`TGCCCC/TTTGCC`	1	--	ng5¹		1		MN	184
--	rs11587525^1,2	C	1275221(+)	`ATGGGA/GGGAGT`	1	--	ng3¹		0	--	--	--	--
--	rs11587543^1,2	C	1275289(+)	`GGGGCA/Tggagc`	1	--	ng3¹		0	--	--	--	--
--	rs307370^1,2	C,F,H	1263141(-)	`cccagC/Ttccac`	1	--	int¹		1		WA	120
--	rs307371^1,2	C,F	1262979(-)	`GCCAGC/TGTGAA`	1	--	int¹		1		EA	1282
--	rs307356^1,2	A,F	1272133(+)	`CAGGGC/TCAGTG`	1	--	int¹		8		NA EA MN	590
	rs3855955^1,2	C	1265940(-)	`TTTGCC/TTGTCT`	1	--	int¹		0	--	--	--	--
--	rs307368^1,2	C	1264213(+)	`GCCCCA/GCCCGA`	1	--	int¹		0	--	--	--	--
--	rs307364^1,2	C	1266341(+)	`acaccG/Tgcaca`	1	--	int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for DVL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601365

5 Novoseek disease relationships for DVL1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis	73.13	6	10617280 (1), 11818547 (1), 10944533 (1), 18662704 (1) (see all 5)
cervical cancer	13.12	1	16457155 (1)
cancer	9.42	2	12824876 (1), 12883684 (1)
tumors	8.17	1	12824876 (1)
breast cancer	0.00	2	12824876 (2)

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Genetic Association Database: DVL1
Human Genome Epidemiology Navigator: DVL1 (1 document)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/76 PubMed articles for DVL1 gene (see all 76 ):

Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease. (PubMed id 11803455)^{1, 3, 6} Russ C....Powell J.F. (2002)
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. (PubMed id 15852005)^{3, 4} Simons M.... Walz G. (2005)
Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway. (PubMed id 14750955)^{3, 4} Oshita A.... Kikuchi A. (2003)
Human dishevelled genes constitute a DHR-containing multigene family. (PubMed id 9192851)^{3, 4} Semenov M.V. and Snyder M. (1997)
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. (PubMed id 8817329)^{2, 3} Pizzuti A.... Dallapiccola B. (1996)
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. (PubMed id 18093802)^{1, 3} Lee Y.N....Wang H.Y. (2008)
Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer. (PubMed id 16457155)^{1, 3} Mizutani K....Onda M. (2005)
Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PubMed id 12556519)^{1, 3} Hino S.... Kikuchi A. (2003)
Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. (PubMed id 18692936)^{1, 3} Wei Q....Wang E.H. (2008)
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PubMed id 11113207)^{1, 3} Hino S.... Kikuchi A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1855	HGNC: 3084	AceView: DVL1	Ensembl:ENSG00000107404	euGenes: HUgn1855
ECgene: DVL1	H-InvDB: DVL1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for DVL1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DVL1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DVL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DVL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DVL1		Antibodies for DVL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DVL1)
	Antibodies (DVL1)
	Chimera RNAi (DVL1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Dishevelled / Dvl1)
	Antibodies (Dishevelled / Dvl1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for DVL1

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Antibodies for DVL1

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DVL1 Gene at Home site.
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DVL1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for DVL1

Summaries
for DVL1

Genomic Location
for DVL1

Proteins
for DVL1

Protein Domains/
Families
for DVL1

Gene Function
for DVL1

Pathways & Interactions
for DVL1

Drugs & Compounds
for DVL1

Transcripts
for DVL1

Expression
for DVL1

Orthologs
for DVL1

Paralogs
for DVL1

SNPs/Variants
for DVL1

Disorders & Mutations
for DVL1

Medical News
for DVL1

Publications
for DVL1

Search for DVL1

Genome Databases showing DVL1

Other Databases showing DVL1

Specialized Databases showing DVL1

Licensable Technologies
for DVL1

Services
for DVL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DVL1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor DVL1

Summariesfor DVL1

Genomic Locationfor DVL1

Proteinsfor DVL1

Protein Domains/Familiesfor DVL1

Gene Functionfor DVL1

Pathways & Interactionsfor DVL1

Drugs & Compoundsfor DVL1

Transcriptsfor DVL1

Expression for DVL1

Orthologsfor DVL1

Paralogsfor DVL1

SNPs/Variantsfor DVL1

Disorders & Mutationsfor DVL1

Medical Newsfor DVL1

Publicationsfor DVL1

Search for DVL1

Genome Databases showing DVL1

Other Databases showing DVL1

Specialized Databases showing DVL1

Licensable Technologiesfor DVL1

Servicesfor DVL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DVL1

Summaries
for DVL1

Genomic Location
for DVL1

Proteins
for DVL1

Protein Domains/
Families
for DVL1

Gene Function
for DVL1

Pathways & Interactions
for DVL1

Drugs & Compounds
for DVL1

Transcripts
for DVL1

Expression
for DVL1

Orthologs
for DVL1

Paralogs
for DVL1

SNPs/Variants
for DVL1

Disorders & Mutations
for DVL1

Medical News
for DVL1

Publications
for DVL1

Licensable Technologies
for DVL1

Services
for DVL1