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Aliases for DUXA Gene

Aliases for DUXA Gene

  • Double Homeobox A 2 3 5

External Ids for DUXA Gene

Previous GeneCards Identifiers for DUXA Gene

  • GC19U900487
  • GC19M062354
  • GC19M057663
  • GC19M053975

Summaries for DUXA Gene

Entrez Gene Summary for DUXA Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUXA Gene

DUXA (Double Homeobox A) is a Protein Coding gene. Diseases associated with DUXA include Facioscapulohumeral Muscular Dystrophy 1. An important paralog of this gene is DUX4.

UniProtKB/Swiss-Prot for DUXA Gene

  • Putative transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUXA Gene

Genomics for DUXA Gene

Regulatory Elements for DUXA Gene

Enhancers for DUXA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUXA on UCSC Golden Path with GeneCards custom track

Genomic Location for DUXA Gene

Chromosome:
19
Start:
57,151,726 bp from pter
End:
57,167,488 bp from pter
Size:
15,763 bases
Orientation:
Minus strand

Genomic View for DUXA Gene

Genes around DUXA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUXA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUXA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUXA Gene

Proteins for DUXA Gene

  • Protein details for DUXA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NLW8-DUXA_HUMAN
    Recommended name:
    Double homeobox protein A
    Protein Accession:
    A6NLW8

    Protein attributes for DUXA Gene

    Size:
    204 amino acids
    Molecular mass:
    23817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUXA Gene

Proteomics data for DUXA Gene at MOPED

Post-translational modifications for DUXA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUXA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DUXA

No data available for DME Specific Peptides for DUXA Gene

Domains & Families for DUXA Gene

Gene Families for DUXA Gene

Protein Domains for DUXA Gene

Suggested Antigen Peptide Sequences for DUXA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NLW8

UniProtKB/Swiss-Prot:

DUXA_HUMAN :
  • Contains 2 homeobox DNA-binding domains.
  • Belongs to the paired homeobox family.
Domain:
  • Contains 2 homeobox DNA-binding domains.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DUXA: view

Function for DUXA Gene

Molecular function for DUXA Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.
genes like me logo Genes that share phenotypes with DUXA: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUXA Gene

Localization for DUXA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUXA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUXA Gene COMPARTMENTS Subcellular localization image for DUXA gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for DUXA Gene

Pathways & Interactions for DUXA Gene

SuperPathways for DUXA Gene

No Data Available

Interacting Proteins for DUXA Gene

Gene Ontology (GO) - Biological Process for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DUXA: view

No data available for Pathways by source and SIGNOR curated interactions for DUXA Gene

Drugs & Compounds for DUXA Gene

No Compound Related Data Available

Transcripts for DUXA Gene

mRNA/cDNA for DUXA Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUXA Gene

Double homeobox A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUXA Gene

No ASD Table

Relevant External Links for DUXA Gene

GeneLoc Exon Structure for
DUXA
ECgene alternative splicing isoforms for
DUXA

Expression for DUXA Gene

mRNA expression in normal human tissues for DUXA Gene

mRNA differential expression in normal tissues according to GTEx for DUXA Gene

This gene is overexpressed in Artery - Coronary (x9.6), Artery - Aorta (x8.4), Testis (x7.3), Artery - Tibial (x7.3), and Adipose - Subcutaneous (x4.8).

SOURCE GeneReport for Unigene cluster for DUXA Gene Hs.585857

genes like me logo Genes that share expression patterns with DUXA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DUXA Gene

Orthologs for DUXA Gene

This gene was present in the common ancestor of mammals.

Orthologs for DUXA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUXA 35
  • 76.29 (n)
  • 67.11 (a)
chimpanzee
(Pan troglodytes)
Mammalia DUXA 35
  • 99.35 (n)
  • 99.02 (a)
DUXA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUXA 36
  • 67 (a)
OneToOne
Species with no ortholog for DUXA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DUXA Gene

ENSEMBL:
Gene Tree for DUXA (if available)
TreeFam:
Gene Tree for DUXA (if available)

Paralogs for DUXA Gene

Paralogs for DUXA Gene

(12) SIMAP similar genes for DUXA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUXA: view

Variants for DUXA Gene

Sequence variations from dbSNP and Humsavar for DUXA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12979459 -- 57,169,123(+) cagtt(A/G)acaaa upstream-variant-2KB
rs12979892 -- 57,169,242(+) accac(A/T)ccctt upstream-variant-2KB
rs8101121 -- 57,164,587(+) ataaa(A/T)ttaaa intron-variant
rs12981544 -- 57,154,723(+) CACGC(C/T)CGGCT intron-variant
rs8102059 -- 57,164,583(+) aaaaa(A/T)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUXA Gene

Variant ID Type Subtype PubMed ID
nsv912523 CNV Gain 21882294
nsv817876 CNV Gain 17921354
esv2669559 CNV Deletion 23128226

Variation tolerance for DUXA Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUXA Gene

Disorders for DUXA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUXA Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search DUXA in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUXA

Genetic Association Database (GAD)
DUXA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUXA
genes like me logo Genes that share disorders with DUXA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUXA Gene

Publications for DUXA Gene

  1. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans G.H. … . (N. Engl. J. Med. 2011) 3 48 67
  2. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3

Products for DUXA Gene

Sources for DUXA Gene

Content