DUXA Gene
protein-coding GIFtS: 34
GCID: GC19M057663
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double homeobox A
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Aliases
for DUXA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Double Homeobox A1 2 | | Double Homeobox Protein A2 |
Export aliases for DUXA gene to outside databasesPrevious GC identifers: GC19U900487 GC19M062354 GC19M053975 |
Summaries
for DUXA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DUXA:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development.Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is amember of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple,related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line orembryonic cells. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DUXA_HUMAN, A6NLW8Function: Putative transcription factor (By similarity)
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Genomic Views
for DUXA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DUXA gene promoter:
GATA-3 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Meis-1b GATA-1 GATA-2 FAC1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUXA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUXA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43DUXA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M057663: view genomic region
(about GC identifiers)
Start:
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57,663,094 bp from pter |
End:
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57,678,856 bp from pter |
Size:
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15,763 bases |
Orientation:
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minus strand |
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Proteins
for DUXA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUXA_HUMAN, A6NLW8 (See
protein sequence)Recommended Name: Double homeobox protein A Size: 204 amino acids; 23817 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for DUXA: NX_A6NLW8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NLW8
DUXA Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001012747.1
ENSEMBL proteins: ENSP00000452398
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
DUXA for ontologies About GeneDecksing
DUXA Antibody Products:
Assay Products for DUXA: |
Protein
Domains /
Families
for DUXA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUXA for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NLW8ProtoNet protein and cluster: A6NLW8 UniProtKB/Swiss-Prot: DUXA_HUMAN, A6NLW8Similarity: Belongs to the paired homeobox familySimilarity: Contains 2 homeobox DNA-binding domains |
Function
for DUXA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUXA_HUMAN, A6NLW8Function: Putative transcription factor (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUXA
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUXA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUXA |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
DUXA for ontologies About GeneDecksing
|
Pathways & Interactions
for DUXA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUXA
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
DUXA for ontologies About GeneDecksing
|
Drugs & Compounds
for DUXA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUXA
Search CenterWatch for drugs/clinical trials and news about DUXA
|
Transcripts
for DUXA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUXA gene: NM_001012729.1 Unigene Cluster for DUXA: Double homeobox A Hs.585857 Unigene Representative Sequence: NM_0010127291 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000554048(uc002qoa.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUXA
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUXA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for DUXA | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUXA | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DUXA |
GeneLoc Exon Structure
|
Expression
for DUXA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUXA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.585857
SABiosciences Custom PCR Arrays for DUXA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUXA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DUXA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUXA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUXA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUXA |
Orthologs
for DUXA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DUXA gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
mxtx26mxtx16 |
mix-type homeobox gene 1 |
12(a)12(a) |
many ↔ manymany ↔ many |
12(30784435-30785976) 13(21796925-21800415) |
Species with no ortholog for DUXA
ENSEMBL Gene Tree for DUXA (if available)
TreeFam Gene Tree for DUXA (if available) |
Paralogs
for DUXA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUXA gene
- DUX4L32 ENSG000002143252 DUX4L42 DUX4L52 DUX4L22 DUX42 DUX4L72 DUX4L62
12 SIMAP similar genes for DUXA using alignment to 1 protein entry: DUXA_HUMAN:DUX5 DUX4L2 DUX4L3 DUX4L4 DUX4L5 DUX4L6
DUX4L7 DUX4L9 DUX4 DUX1 DUX3 POU6F1
DUXA for paralogs About GeneDecksing
5/13 Pseudogenes.org Pseudogenes for DUXA (see all 13)
PGOHUM00000238434 PGOHUM00000238760 PGOHUM00000242505 PGOHUM00000247716 PGOHUM00000247847
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Genomic Variants
for DUXA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DUXA (57663094 - 57678856 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DUXA
1 CNV: 9817 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DUXA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUXA for disorders About GeneDecksing
OMIM gene information: 611168
OMIM disorders: --
2  diseases for DUXA: About MalaCardsfacioscapulohumeral muscular dystrophy muscular dystrophy
1 disease from the University of Copenhagen DISEASES database for DUXA:Facioscapulohumeral muscular dystrophy Export disorders for DUXA gene to outside databases
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Publications
for DUXA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUXA gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUXA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PubMed id 17005330)1, 2 Booth H.A. and Holland P.W.H. (2007)
- Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1 Dolmans G.H.... . (2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
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External Searches for DUXA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DUXA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUXA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUXA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUXA | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DUXA gene:
Search GeneIP for patents involving DUXA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUXA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DUXA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUXA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUXA | | | OriGene Protein Over-expression Lysate for DUXA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DUXA | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUXA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUXA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DUXA | | OriGene Custom Protein Services for DUXA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUXA | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUXA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUXA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUXA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUXA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUXA |
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 |  |  |  | |
| | | | Search Tocris compounds for DUXA |
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 | | | DUXA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUXA |
|  |  |  | | | | Search ThermoFisher Antibodies for DUXA |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DUXA |
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