Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUXA Gene

Aliases for DUXA Gene

  • Double Homeobox A 2 3 5

External Ids for DUXA Gene

Previous GeneCards Identifiers for DUXA Gene

  • GC19U900487
  • GC19M062354
  • GC19M057663
  • GC19M053975

Summaries for DUXA Gene

Entrez Gene Summary for DUXA Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUXA Gene

DUXA (Double Homeobox A) is a Protein Coding gene. Diseases associated with DUXA include Facioscapulohumeral Muscular Dystrophy 1. An important paralog of this gene is DUX4.

UniProtKB/Swiss-Prot for DUXA Gene

  • Putative transcription factor.

Additional gene information for DUXA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUXA Gene

Genomics for DUXA Gene

Regulatory Elements for DUXA Gene

Enhancers for DUXA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H057190 1 ENCODE 9.6 -24.3 -24318 1.9 PKNOX1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 KLF7 RUNX3 ZNF548 ZNF417 ZNF134 ZNF274 AURKC ZNF773 ZNF550 ZNF264 ZIM3 ZNF805
GH19H057171 1.1 Ensembl ENCODE 0.7 -4.7 -4714 1.6 MXI1 KLF1 SAP130 ZNF2 ZFHX2 ZNF366 POLR2A ZNF600 PRDM10 KLF8 LOC100132009 AURKC ZNF805 GC19M057103 DUXA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUXA on UCSC Golden Path with GeneCards custom track

Genomic Locations for DUXA Gene

Genomic Locations for DUXA Gene
15,763 bases
Minus strand

Genomic View for DUXA Gene

Genes around DUXA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUXA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUXA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUXA Gene

Proteins for DUXA Gene

  • Protein details for DUXA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Double homeobox protein A
    Protein Accession:

    Protein attributes for DUXA Gene

    204 amino acids
    Molecular mass:
    23817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUXA Gene

Post-translational modifications for DUXA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUXA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUXA Gene

Domains & Families for DUXA Gene

Gene Families for DUXA Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DUXA Gene

Suggested Antigen Peptide Sequences for DUXA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paired homeobox family.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DUXA: view

Function for DUXA Gene

Molecular function for DUXA Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Phenotypes From GWAS Catalog for DUXA Gene

Gene Ontology (GO) - Molecular Function for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with DUXA: view
genes like me logo Genes that share phenotypes with DUXA: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUXA Gene

Localization for DUXA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUXA Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUXA gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DUXA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DUXA Gene

Pathways & Interactions for DUXA Gene

No Data Available

Interacting Proteins for DUXA Gene

Gene Ontology (GO) - Biological Process for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DUXA: view

No data available for Pathways by source and SIGNOR curated interactions for DUXA Gene

Drugs & Compounds for DUXA Gene

No Compound Related Data Available

Transcripts for DUXA Gene

mRNA/cDNA for DUXA Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUXA Gene

Double homeobox A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUXA Gene

No ASD Table

Relevant External Links for DUXA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUXA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUXA Gene

mRNA differential expression in normal tissues according to GTEx for DUXA Gene

This gene is overexpressed in Artery - Coronary (x9.6), Artery - Aorta (x8.4), Testis (x7.3), Artery - Tibial (x7.3), and Adipose - Subcutaneous (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of DUXA Gene:


SOURCE GeneReport for Unigene cluster for DUXA Gene:

genes like me logo Genes that share expression patterns with DUXA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUXA Gene

Orthologs for DUXA Gene

This gene was present in the common ancestor of mammals.

Orthologs for DUXA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUXA 34 33
  • 99.35 (n)
(Bos Taurus)
Mammalia DUXA 33
  • 76.29 (n)
(Canis familiaris)
Mammalia DUXA 34
  • 67 (a)
Species where no ortholog for DUXA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DUXA Gene

Gene Tree for DUXA (if available)
Gene Tree for DUXA (if available)

Paralogs for DUXA Gene

Variants for DUXA Gene

Sequence variations from dbSNP and Humsavar for DUXA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000149076 -- 57,153,750(+) ACTTT(C/T)AGCCA utr-variant-3-prime
rs1000158882 -- 57,153,978(+) GTTAT(A/G)ACGTC utr-variant-3-prime
rs1000284050 -- 57,169,203(+) ATAAT(C/T)AAATC upstream-variant-2KB
rs1000300830 -- 57,159,789(+) CTAAA(A/T)ACAAA intron-variant
rs1000491347 -- 57,163,733(+) CAATT(G/T)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUXA Gene

Variant ID Type Subtype PubMed ID
nsv817876 CNV gain 17921354
nsv580400 CNV gain 21841781
nsv1064109 CNV gain 25217958
esv3893256 CNV loss 25118596
esv3644895 CNV gain 21293372
esv3644894 CNV loss 21293372
esv2669559 CNV deletion 23128226

Variation tolerance for DUXA Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUXA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUXA Gene

Disorders for DUXA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUXA Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search DUXA in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUXA

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DUXA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUXA Gene

Publications for DUXA Gene

  1. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans GH … BSSH-GODD Consortium (The New England journal of medicine 2011) 3 45 60
  2. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth HA … Holland PW (Gene 2007) 3 4 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for DUXA Gene

Sources for DUXA Gene

Loading form....