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Aliases for DUXA Gene

Aliases for DUXA Gene

  • Double Homeobox A 2 3

External Ids for DUXA Gene

Previous GeneCards Identifiers for DUXA Gene

  • GC19U900487
  • GC19M062354
  • GC19M057663
  • GC19M053975

Summaries for DUXA Gene

Entrez Gene Summary for DUXA Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUXA Gene

DUXA (Double Homeobox A) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is DUX4L6.

UniProtKB/Swiss-Prot for DUXA Gene

  • Putative transcription factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUXA Gene

Genomics for DUXA Gene

Genomic Location for DUXA Gene

57,151,726 bp from pter
57,167,488 bp from pter
15,763 bases
Minus strand

Genomic View for DUXA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUXA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUXA Gene

Proteins for DUXA Gene

  • Protein details for DUXA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Double homeobox protein A
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DUXA Gene

    204 amino acids
    Molecular mass:
    23817 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUXA Gene

Proteomics data for DUXA Gene at MOPED

Post-translational modifications for DUXA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUXA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUXA Gene

Domains for DUXA Gene

Gene Families for DUXA Gene

  • PRD :Homeoboxes / PRD class

Protein Domains for DUXA Gene

Suggested Antigen Peptide Sequences for DUXA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A6NLW8
  • Contains 2 homeobox DNA-binding domains.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DUXA: view

Function for DUXA Gene

Molecular function for DUXA Gene

UniProtKB/Swiss-Prot Function:
Putative transcription factor.

Gene Ontology (GO) - Molecular Function for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with DUXA: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUXA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUXA Gene

Localization for DUXA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUXA Gene

Subcellular locations from

Jensen Localization Image for DUXA Gene COMPARTMENTS Subcellular localization image for DUXA gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DUXA: view

Pathways for DUXA Gene

SuperPathways for DUXA Gene

No Data Available

Interacting Proteins for DUXA Gene

Gene Ontology (GO) - Biological Process for DUXA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DUXA: view

No data available for Pathways by source for DUXA Gene

Transcripts for DUXA Gene

mRNA/cDNA for DUXA Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUXA Gene

Double homeobox A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUXA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUXA Gene

No ASD Table

Relevant External Links for DUXA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUXA Gene

mRNA expression in normal human tissues for DUXA Gene

mRNA differential expression in normal tissues according to GTEx for DUXA Gene

This gene is overexpressed in Artery - Coronary (9.6), Artery - Aorta (8.4), Testis (7.3), Artery - Tibial (7.3), and Adipose - Subcutaneous (4.8).

SOURCE GeneReport for Unigene cluster for DUXA Gene Hs.585857

genes like me logo Genes that share expressions with DUXA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for DUXA Gene

Orthologs for DUXA Gene

This gene was present in the common ancestor of mammals.

Orthologs for DUXA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUXA 35
  • 76.29 (n)
  • 67.11 (a)
(Pan troglodytes)
Mammalia DUXA 35
  • 99.35 (n)
  • 99.02 (a)
  • 99 (a)
(Canis familiaris)
Mammalia DUXA 36
  • 67 (a)
Species with no ortholog for DUXA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DUXA Gene

Gene Tree for DUXA (if available)
Gene Tree for DUXA (if available)

Paralogs for DUXA Gene

Paralogs for DUXA Gene

Selected SIMAP similar genes for DUXA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUXA: view

Variants for DUXA Gene

Sequence variations from dbSNP and Humsavar for DUXA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3082068 -- 57,165,805(-) TTTTT(-/T)TGAGA intron-variant
rs4801201 -- 57,158,803(+) TATGG(C/T)GAAAC intron-variant
rs4801202 -- 57,162,810(+) ACCTC(C/G)TGATC intron-variant
rs4801203 -- 57,166,041(+) TAACA(C/T)GAACA intron-variant
rs4801434 -- 57,158,734(+) ATGCC(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUXA Gene

Variant ID Type Subtype PubMed ID
nsv912523 CNV Gain 21882294
nsv817876 CNV Gain 17921354
esv2669559 CNV Deletion 23128226

Relevant External Links for DUXA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUXA Gene

Disorders for DUXA Gene

(1) University of Copenhagen DISEASES for DUXA Gene

Relevant External Links for DUXA

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DUXA: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for DUXA Gene

Publications for DUXA Gene

  1. Annotation, nomenclature and evolution of four novel homeobox genes expressed in the human germ line. (PMID: 17005330) Booth H.A. … Holland P.W.H. (Gene 2007) 3 4
  2. Wnt signaling and Dupuytren's disease. (PMID: 21732829) Dolmans G.H. … . (N. Engl. J. Med. 2011) 3 48
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for DUXA Gene

Sources for DUXA Gene

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