DUX4L9 Gene
pseudogene GIFtS: 24
GCID: GC04M190943
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double homeobox 4 like 9
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Aliases
for DUX4L9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Double Homeobox 4 Like 91 2 | | DUX4C2 3 | | DUX4c3 | | Double Homeobox Protein 4-Like Protein 93 |
Export aliases for DUX4L9 gene to outside databases |
Summaries
for DUX4L9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DUX4C_HUMAN, Q6RFH8Function: May be involved in transcriptional regulation (By similarity). May play a role in cell proliferationspecifically in the process of muscle regeneration
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Genomic Views
for DUX4L9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NT_016354.19 NC_018915.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DUX4L9
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUX4L9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4L9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.2 Ensembl cytogenetic band: 4q35.2 HGNC cytogenetic band: 4q35.2DUX4L9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M190943: view genomic region
(about GC identifiers)
Start:
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190,940,255 bp from pter |
End:
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190,945,506 bp from pter |
Size:
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5,252 bases |
Orientation:
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minus strand |
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Proteins
for DUX4L9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUX4C_HUMAN, Q6RFH8 (See
protein sequence)Recommended Name: Double homeobox protein 4C Size: 374 amino acids; 39442 Da
Subunit: May interact with MYF5; regulates MYF5 expression
Subcellular location: Nucleus
Developmental stage: Up-regulated during myoblasts differentiation (at protein level)
Miscellaneous: Up-regulated in myoblasts of facioscapulohumeral muscular dystrophy (FSHD) patients (at protein level)Explore the universe of human proteins at neXtProt for DUX4L9: NX_Q6RFH8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6RFH8
DUX4L9 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
DUX4L9 for ontologies About GeneDecksing
DUX4L9 Antibody Products:
Assay Products for DUX4L9: |
Protein
Domains /
Families
for DUX4L9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUX4L9 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6RFH8ProtoNet protein and cluster: Q6RFH8 1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature
UniProtKB/Swiss-Prot: DUX4C_HUMAN, Q6RFH8Similarity: Contains 2 homeobox DNA-binding domains |
Function
for DUX4L9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUX4C_HUMAN, Q6RFH8Function: May be involved in transcriptional regulation (By similarity). May play a role in cell proliferationspecifically in the process of muscle regeneration
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 19829708 |
DUX4L9 for ontologies About GeneDecksing
|
Pathways & Interactions
for DUX4L9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUX4L9
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
DUX4L9 for ontologies About GeneDecksing
|
Drugs & Compounds
for DUX4L9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUX4L9
Search CenterWatch for drugs/clinical trials and news about DUX4L9 
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Transcripts
for DUX4L9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUX4L9 gene (2 alternative transcripts): NM_001023569.1 NM_001099853.1 Unigene Cluster for DUX4L9: Double homeobox 4 like 9 Hs.742140 Unigene Representative Sequence: XR_1098201 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000449051
Additional cDNA sequence: XR_109820.2 XR_132460.2 XR_133387.1
GeneLoc Exon Structure
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Expression
for DUX4L9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUX4L9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.742140
UniProtKB/Swiss-Prot: DUX4C_HUMAN, Q6RFH8Tissue specificity: Expressed in myocytes (at protein level)
SABiosciences Custom PCR Arrays for DUX4L9
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUX4L9
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DUX4L9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4L9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4L9 |
Orthologs
for DUX4L9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DUX4L9 (if available)
TreeFam Gene Tree for DUX4L9 (if available) |
Paralogs
for DUX4L9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DUX4L9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DUX4L9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUX4L9 for disorders About GeneDecksing
2  diseases for DUX4L9: About MalaCardsfacioscapulohumeral muscular dystrophy muscular dystrophy
1 disease from the University of Copenhagen DISEASES database for DUX4L9:Facioscapulohumeral muscular dystrophy Export disorders for DUX4L9 gene to outside databases
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Publications
for DUX4L9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUX4L9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUX4L9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DUX4c is up-regulated in FSHD. It induces the MYF5 pr otein and human myoblast proliferation. (PubMed id 19829708)1, 2 Ansseau E....CoppAce F. (2009)
- The KrA1ppel-like factor 15 as a molecular link betwee n myogenic factors and a chromosome 4q transcriptional enhancer implicated in f acioscapulohumeral dystrophy. (PubMed id 21937448)1 Dmitriev P....Vassetzky Y.S. (2011)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PubMed id 10433963)1 Gabrieels J.... Belayew A. (1999)
- The FSHD-associated repeat, D4Z4, is a member of a dispersed family of homeobox-containing repeats, subsets of which are clustered on the short arms of the acrocentric chromosomes. (PubMed id 7490072)1 Lyle R.... Hewitt J.E. (1995)
- Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy. (PubMed id 7987304)1 Hewitt J.E.... Williamson R. (1994)
- Fine mapping of the FSHD gene region orientates the rearranged fragment detected by the probe p13E-11. (PubMed id 7903581)1 Wright T.J....Hewitt J.E. (1993)
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External Searches for DUX4L9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DUX4L9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing DUX4L9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUX4L9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for DUX4L9 gene:
Search GeneIP for patents involving DUX4L9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUX4L9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUX4L9 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUX4L9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4L9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUX4L9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4L9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4L9 |
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| | | | Search Tocris compounds for DUX4L9 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for DUX4L9 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DUX4L9 |
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