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Aliases for DUX4L9 Gene

Subcategory (RNA class) for DUX4L9 Gene

lncRNA

Aliases for DUX4L9 Gene

  • Double Homeobox 4 Like 9 2 3
  • DUX4C 3 4 6
  • Double Homeobox 4 Like 9 (Pseudogene) 2 3
  • Double Homeobox Protein 4-Like Protein 9 4
  • Double Homeobox Protein 4, Centromeric 4
  • Double Homeobox 4 Pseudogene 3
  • Double Homeobox 4c 3

External Ids for DUX4L9 Gene

ORGUL Members for DUX4L9 Gene

Summaries for DUX4L9 Gene

GeneCards Summary for DUX4L9 Gene

DUX4L9 (Double Homeobox 4 Like 9) is a Pseudogene, and belongs to lncRNA RNA class. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding.

UniProtKB/Swiss-Prot for DUX4L9 Gene

  • May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L9 Gene

Genomics for DUX4L9 Gene

Genomic Location for DUX4L9 Gene

Start:
190,021,407 bp from pter
End:
190,022,762 bp from pter
Size:
1,356 bases
Orientation:
Minus strand

Genomic View for DUX4L9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUX4L9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUX4L9 Gene

No data available for Regulatory Elements for DUX4L9 Gene

Proteins for DUX4L9 Gene

  • Protein details for DUX4L9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RFH8-DUX4C_HUMAN
    Recommended name:
    Double homeobox protein 4C
    Protein Accession:
    Q6RFH8
    Secondary Accessions:

    Protein attributes for DUX4L9 Gene

    Size:
    374 amino acids
    Molecular mass:
    39442 Da
    Quaternary structure:
    • May interact with MYF5; regulates MYF5 expression

neXtProt entry for DUX4L9 Gene

Proteomics data for DUX4L9 Gene at MOPED

Post-translational modifications for DUX4L9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUX4L9 Gene

Domains for DUX4L9 Gene

Gene Families for DUX4L9 Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for DUX4L9 Gene

UniProtKB/Swiss-Prot:

DUX4C_HUMAN
Domain:
  • Contains 2 homeobox DNA-binding domains.:
    • Q6RFH8
genes like me logo Genes that share domains with DUX4L9: view

Function for DUX4L9 Gene

Molecular function for DUX4L9 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUX4L9 Gene

Localization for DUX4L9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUX4L9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUX4L9 Gene COMPARTMENTS Subcellular localization image for DUX4L9 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for DUX4L9 Gene

Pathways for DUX4L9 Gene

SuperPathways for DUX4L9 Gene

No Data Available

Interacting Proteins for DUX4L9 Gene

Gene Ontology (GO) - Biological Process for DUX4L9 Gene

None

No data available for Pathways by source for DUX4L9 Gene

Transcripts for DUX4L9 Gene

mRNA/cDNA for DUX4L9 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L9 Gene

No ASD Table

Relevant External Links for DUX4L9 Gene

GeneLoc Exon Structure for
DUX4L9
ECgene alternative splicing isoforms for
DUX4L9

Expression for DUX4L9 Gene

mRNA expression in normal human tissues for DUX4L9 Gene

mRNA differential expression in normal tissues according to GTEx for DUX4L9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (16.4) and Brain - Cerebellum (14.4).

mRNA Expression by UniProt/SwissProt for DUX4L9 Gene

Q6RFH8-DUX4C_HUMAN
Tissue specificity: Expressed in muscles, as well as in primary myoblasts and myotubes (at protein level).
genes like me logo Genes that share expressions with DUX4L9: view

Orthologs for DUX4L9 Gene

Evolution for DUX4L9 Gene

ENSEMBL:
Gene Tree for DUX4L9 (if available)
TreeFam:
Gene Tree for DUX4L9 (if available)

No data available for Orthologs for DUX4L9 Gene

Paralogs for DUX4L9 Gene

Selected SIMAP similar genes for DUX4L9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUX4L9: view

No data available for Paralogs for DUX4L9 Gene

Variants for DUX4L9 Gene

Relevant External Links for DUX4L9 Gene

HapMap Linkage Disequilibrium report
DUX4L9

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for DUX4L9 Gene

Disorders for DUX4L9 Gene

UniProtKB/Swiss-Prot

DUX4C_HUMAN
  • Note=Up-regulated in myoblasts of facioscapulohumeral muscular dystrophy (FSHD) patients (at protein level). {ECO:0000269 PubMed:19829708}.

(1) University of Copenhagen DISEASES for DUX4L9 Gene

genes like me logo Genes that share disorders with DUX4L9: view

Publications for DUX4L9 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  2. DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation. (PMID: 18723017) Bosnakovski D. … Kyba M. (Exp. Neurol. 2008) 3 4
  3. DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation. (PMID: 19829708) Ansseau E. … Coppee F. (PLoS ONE 2009) 3 4
  4. Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients. (PMID: 24145033) Dmitriev P. … Vassetzky Y.S. (J. Biol. Chem. 2013) 3 4
  5. Testing the effects of FSHD candidate gene expression in vertebrate muscle development. (PMID: 20490329) Wuebbles R.D. … Jones P.L. (Int J Clin Exp Pathol 2010) 3

Products for DUX4L9 Gene

Sources for DUX4L9 Gene

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