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Aliases for DUX4L9 Gene

Subcategory (RNA class) for DUX4L9 Gene

lncRNA

Aliases for DUX4L9 Gene

  • Double Homeobox 4 Like 9 2 3 5
  • Double Homeobox 4 Like 9 (Pseudogene) 2 3
  • DUX4C 3 4
  • Double Homeobox Protein 4-Like Protein 9 4
  • Double Homeobox Protein 4, Centromeric 4
  • Double Homeobox 4 Pseudogene 3
  • Double Homeobox 4c 3

External Ids for DUX4L9 Gene

ORGUL Members for DUX4L9 Gene

Previous GeneCards Identifiers for DUX4L9 Gene

  • GC04M190943

Summaries for DUX4L9 Gene

GeneCards Summary for DUX4L9 Gene

DUX4L9 (Double Homeobox 4 Like 9) is a Pseudogene, and is affiliated with the lncRNA class.

UniProtKB/Swiss-Prot for DUX4L9 Gene

  • May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L9 Gene

Genomics for DUX4L9 Gene

Regulatory Elements for DUX4L9 Gene

Promoters for DUX4L9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUX4L9 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUX4L9 Gene

Chromosome:
4
Start:
190,021,169 bp from pter
End:
190,022,665 bp from pter
Size:
1,497 bases
Orientation:
Minus strand

Genomic View for DUX4L9 Gene

Genes around DUX4L9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUX4L9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUX4L9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUX4L9 Gene

Proteins for DUX4L9 Gene

  • Protein details for DUX4L9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RFH8-DUX4C_HUMAN
    Recommended name:
    Double homeobox protein 4C
    Protein Accession:
    Q6RFH8

    Protein attributes for DUX4L9 Gene

    Size:
    374 amino acids
    Molecular mass:
    39442 Da
    Quaternary structure:
    • May interact with MYF5; regulates MYF5 expression.

neXtProt entry for DUX4L9 Gene

Proteomics data for DUX4L9 Gene at MOPED

Post-translational modifications for DUX4L9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUX4L9 Gene

Domains & Families for DUX4L9 Gene

Gene Families for DUX4L9 Gene

Protein Domains for DUX4L9 Gene

Suggested Antigen Peptide Sequences for DUX4L9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6RFH8

UniProtKB/Swiss-Prot:

DUX4C_HUMAN :
  • Contains 2 homeobox DNA-binding domains.
Domain:
  • Contains 2 homeobox DNA-binding domains.
genes like me logo Genes that share domains with DUX4L9: view

Function for DUX4L9 Gene

Molecular function for DUX4L9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation (By similarity). Down-regulates MYOD1 expression and may up-regulate MYF5 expression. May regulate microRNA (miRNA) transcription, upregulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206. Impairs the differentiation of myoblasts and may be involved in muscle regeneration.

Phenotypes for DUX4L9 Gene

GenomeRNAi human phenotypes for DUX4L9:
genes like me logo Genes that share phenotypes with DUX4L9: view

miRNA for DUX4L9 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUX4L9 Gene

Localization for DUX4L9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUX4L9 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUX4L9 Gene

Pathways & Interactions for DUX4L9 Gene

SuperPathways for DUX4L9 Gene

No Data Available

Interacting Proteins for DUX4L9 Gene

Gene Ontology (GO) - Biological Process for DUX4L9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DUX4L9 Gene

Drugs & Compounds for DUX4L9 Gene

No Compound Related Data Available

Transcripts for DUX4L9 Gene

mRNA/cDNA for DUX4L9 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L9 Gene

No ASD Table

Relevant External Links for DUX4L9 Gene

GeneLoc Exon Structure for
DUX4L9
ECgene alternative splicing isoforms for
DUX4L9

Expression for DUX4L9 Gene

mRNA expression in normal human tissues for DUX4L9 Gene

mRNA differential expression in normal tissues according to GTEx for DUX4L9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x16.4) and Brain - Cerebellum (x14.4).

mRNA Expression by UniProt/SwissProt for DUX4L9 Gene

Q6RFH8-DUX4C_HUMAN
Tissue specificity: Expressed in muscles, as well as in primary myoblasts and myotubes (at protein level).
genes like me logo Genes that share expression patterns with DUX4L9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DUX4L9 Gene

Orthologs for DUX4L9 Gene

Evolution for DUX4L9 Gene

ENSEMBL:
Gene Tree for DUX4L9 (if available)
TreeFam:
Gene Tree for DUX4L9 (if available)

No data available for Orthologs for DUX4L9 Gene

Paralogs for DUX4L9 Gene

(14) SIMAP similar genes for DUX4L9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUX4L9: view

No data available for Paralogs for DUX4L9 Gene

Variants for DUX4L9 Gene

Relevant External Links for DUX4L9 Gene

HapMap Linkage Disequilibrium report
DUX4L9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L9 Gene

Disorders for DUX4L9 Gene

UniProtKB/Swiss-Prot

DUX4C_HUMAN
  • Note=Up-regulated in myoblasts of facioscapulohumeral muscular dystrophy (FSHD) patients (at protein level). {ECO:0000269 PubMed:19829708}.

No disorders were found for DUX4L9 Gene.

No data available for MalaCards , Genatlas and External Links for DUX4L9 Gene

Publications for DUX4L9 Gene

  1. Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients. (PMID: 24145033) Dmitriev P. … Vassetzky Y.S. (J. Biol. Chem. 2013) 3 4 67
  2. The KrA1ppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy. (PMID: 21937448) Dmitriev P. … Vassetzky Y.S. (J. Biol. Chem. 2011) 3
  3. Testing the effects of FSHD candidate gene expression in vertebrate muscle development. (PMID: 20490329) Wuebbles R.D. … Jones P.L. (Int J Clin Exp Pathol 2010) 3
  4. DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation. (PMID: 19829708) Ansseau E. … Coppee F. (PLoS ONE 2009) 3
  5. Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation. (PMID: 19607661) Bodega B. … Ginelli E. (BMC Biol. 2009) 3

Products for DUX4L9 Gene

Sources for DUX4L9 Gene

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