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Aliases for DUX4L8 Gene

Aliases for DUX4L8 Gene

  • Double Homeobox 4 Like 8 2 3
  • Double Homeobox 4 Like 8 (Pseudogene) 2 3
  • Double Homeobox 2 2 3
  • DUX2 3 6
  • Putative Double Homeobox Protein 2 3
  • Double Homeobox, 2 2

External Ids for DUX4L8 Gene

Previous HGNC Symbols for DUX4L8 Gene

  • DUX2

Previous GeneCards Identifiers for DUX4L8 Gene

  • GC04P190991
  • GC04P190993
  • GC04P191000
  • GC04P191019
  • GC04P191024
  • GC04P191029
  • GC04P191034
  • GC04P191041

Summaries for DUX4L8 Gene

Entrez Gene Summary for DUX4L8 Gene

  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

GeneCards Summary for DUX4L8 Gene

DUX4L8 (Double Homeobox 4 Like 8) is a Pseudogene. An important paralog of this gene is DUX4L2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L8 Gene

Genomics for DUX4L8 Gene

Genomic Location for DUX4L8 Gene

190,067,838 bp from pter
190,069,217 bp from pter
1,380 bases
Plus strand

Genomic View for DUX4L8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUX4L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUX4L8 Gene

No data available for Regulatory Elements for DUX4L8 Gene

Proteins for DUX4L8 Gene

  • Protein details for DUX4L8 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein DUX4L8
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DUX4L8 Gene

    424 amino acids
    Molecular mass:
    44988 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUX4L8 Gene

Proteomics data for DUX4L8 Gene at MOPED

Post-translational modifications for DUX4L8 Gene

No Post-translational modifications

Other Protein References for DUX4L8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for DUX4L8 Gene

Domains for DUX4L8 Gene

Gene Families for DUX4L8 Gene

Protein Domains for DUX4L8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DUX4L8: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DUX4L8 Gene

Function for DUX4L8 Gene

Gene Ontology (GO) - Molecular Function for DUX4L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with DUX4L8: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L8 Gene

Localization for DUX4L8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUX4L8 Gene

Pathways for DUX4L8 Gene

SuperPathways for DUX4L8 Gene

No Data Available

Interacting Proteins for DUX4L8 Gene

Gene Ontology (GO) - Biological Process for DUX4L8 Gene


No data available for Pathways by source for DUX4L8 Gene

Transcripts for DUX4L8 Gene

mRNA/cDNA for DUX4L8 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L8 Gene

No ASD Table

Relevant External Links for DUX4L8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUX4L8 Gene

mRNA expression in normal human tissues for DUX4L8 Gene

Protein differential expression in normal tissues for DUX4L8 Gene

This gene is overexpressed in Heart (48.4) and Brain (20.6).

Integrated Proteomics: protein expression from for DUX4L8 Gene

genes like me logo Genes that share expressions with DUX4L8: view

Expression partners for DUX4L8 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUX4L8 Gene

Orthologs for DUX4L8 Gene

Evolution for DUX4L8 Gene

Gene Tree for DUX4L8 (if available)
Gene Tree for DUX4L8 (if available)

No data available for Orthologs for DUX4L8 Gene

Paralogs for DUX4L8 Gene

genes like me logo Genes that share paralogs with DUX4L8: view

Variants for DUX4L8 Gene

Sequence variations from dbSNP and Humsavar for DUX4L8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs74498055 -- 190,068,551(+) GGGGG(A/C)TTTCG missense, reference
rs77415479 -- 190,068,562(+) TGAGC(C/T)AGGCA reference, stop-gained
rs144210490 -- 190,068,522(+) GTGCC(A/C)TGCGC synonymous-codon, reference
rs147855097 -- 190,068,651(+) GATTT(C/T)GCCTA reference, synonymous-codon
rs150358299 -- 190,068,486(+) ACCGG(A/C)GAGTG synonymous-codon, reference

Relevant External Links for DUX4L8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUX4L8 Gene

Disorders for DUX4L8 Gene

No disorders were found for DUX4L8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DUX4L8 Gene

Publications for DUX4L8 Gene

  1. Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35. (PMID: 7739628) Lee J. … Arahata K. (Muscle Nerve 1995) 3
  2. Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3-kb dispersed repeated elements. (PMID: 9736770) Ding H. … Belayew A. (Hum. Mol. Genet. 1998) 3
  3. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PMID: 10433963) Gabrieels J. … Belayew A. (Gene 1999) 3
  4. Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M.-C. … Belayew A. (Gene 2001) 3
  5. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J. … Hewitt J.E. (Am. J. Hum. Genet. 2007) 3

Products for DUX4L8 Gene

Sources for DUX4L8 Gene

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