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DUX4L8 Gene(Pseudogene)

Double Homeobox 4 Like 8

GCID:
GC04P190067
GIFtS:
18
Genes Participants
UDN Logo

Aliases for DUX4L8 Gene

Aliases for DUX4L8 Gene

  • Double Homeobox 4 Like 8 2 3 5
  • Double Homeobox 4 Like 8 (Pseudogene) 2 3
  • Double Homeobox 2 2 3
  • Putative Double Homeobox Protein 2 3
  • Double Homeobox, 2 2
  • DUX2 3

External Ids for DUX4L8 Gene

Previous HGNC Symbols for DUX4L8 Gene

  • DUX2

Previous GeneCards Identifiers for DUX4L8 Gene

  • GC04P190991
  • GC04P190993
  • GC04P191000
  • GC04P191019
  • GC04P191024
  • GC04P191029
  • GC04P191034
  • GC04P191041

Summaries for DUX4L8 Gene

Entrez Gene Summary for DUX4L8 Gene

  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

GeneCards Summary for DUX4L8 Gene

DUX4L8 (Double Homeobox 4 Like 8) is a Pseudogene. An important paralog of this gene is DUX4L3.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L8 Gene

Genomics for DUX4L8 Gene

Products:

  1. Regulatory Element

Genomic Location for DUX4L8 Gene

Chromosome:
4
Start:
190,067,935 bp from pter
End:
190,069,219 bp from pter
Size:
1,285 bases
Orientation:
Plus strand

Genomic View for DUX4L8 Gene

Genes around DUX4L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUX4L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUX4L8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DUX4L8 Gene

No data available for Regulatory Elements for DUX4L8 Gene

Proteins for DUX4L8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Protein Expression for DUX4L8 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DUX4L8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DUX4L8 Gene

Domains & Families for DUX4L8 Gene

Gene Families for DUX4L8 Gene

HGNC:

Suggested Antigen Peptide Sequences for DUX4L8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DUX4L8: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for DUX4L8 Gene

Function for DUX4L8 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
genes like me logo Genes that share phenotypes with DUX4L8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L8 Gene

Localization for DUX4L8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUX4L8 Gene

Pathways & Interactions for DUX4L8 Gene

SuperPathways for DUX4L8 Gene

PathCards logo More details on SuperPathways for DUX4L8
No Data Available

Interacting Proteins for DUX4L8 Gene

Gene Ontology (GO) - Biological Process for DUX4L8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DUX4L8 Gene

Drugs & Compounds for DUX4L8 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DUX4L8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DUX4L8 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L8 Gene

No ASD Table

Relevant External Links for DUX4L8 Gene

GeneLoc Exon Structure for
DUX4L8
ECgene alternative splicing isoforms for
DUX4L8

Expression for DUX4L8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUX4L8 Gene

mRNA expression in normal human tissues for DUX4L8 Gene
mRNA expression by GTEx for DUX4L8 Gene

Protein differential expression in normal tissues from HIPED for DUX4L8 Gene

This gene is overexpressed in Heart (48.4) and Brain (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for DUX4L8 Gene



Protein tissue co-expression partners for DUX4L8 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUX4L8 Gene:

DUX4L8
genes like me logo Genes that share expression patterns with DUX4L8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUX4L8 Gene

Orthologs for DUX4L8 Gene

Evolution for DUX4L8 Gene

ENSEMBL:
Gene Tree for DUX4L8 (if available)
TreeFam:
Gene Tree for DUX4L8 (if available)

No data available for Orthologs for DUX4L8 Gene

Paralogs for DUX4L8 Gene

Paralogs for DUX4L8 Gene

genes like me logo Genes that share paralogs with DUX4L8: view

Variants for DUX4L8 Gene

Relevant External Links for DUX4L8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUX4L8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L8 Gene

Disorders for DUX4L8 Gene

No disorders were found for DUX4L8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DUX4L8 Gene

Publications for DUX4L8 Gene

  1. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J. … Hewitt J.E. (Am. J. Hum. Genet. 2007) 3 64
  2. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M. … Chen Y.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 64
  3. Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M.-C. … Belayew A. (Gene 2001) 3 64
  4. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PMID: 10433963) Gabrieels J. … Belayew A. (Gene 1999) 3 64
  5. Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3-kb dispersed repeated elements. (PMID: 9736770) Ding H. … Belayew A. (Hum. Mol. Genet. 1998) 3 64

Products for DUX4L8 Gene

Sources for DUX4L8 Gene

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