Aliases for DUX4L8 Gene
Aliases for DUX4L8 Gene
External Ids for DUX4L8 Gene
- HGNC: 38670
- Entrez Gene: 26583
- Ensembl: ENSG00000281720
- OMIM: 611442
Previous HGNC Symbols for DUX4L8 Gene
- DUX2
Previous GeneCards Identifiers for DUX4L8 Gene
- GC04P190991
- GC04P190993
- GC04P191000
- GC04P191019
- GC04P191024
- GC04P191029
- GC04P191034
- GC04P191041
Summaries for DUX4L8 Gene
-
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]
GeneCards Summary for DUX4L8 Gene
DUX4L8 (Double Homeobox 4 Like 8) is a Pseudogene. An important paralog of this gene is DUX4L3.
Additional gene information for DUX4L8 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L8 Gene
Genomics for DUX4L8 Gene
Regulatory Element Products
Genomic Locations for DUX4L8 Gene
- chr4:190,067,935-190,069,219
- (GRCh38/hg38)
- Size:
- 1,285 bases
- Orientation:
- Plus strand
- chr4:190,988,796-190,990,406
- (GRCh37/hg19)
Genomic View for DUX4L8 Gene
- Cytogenetic band:
-
- 4q35.2 by Ensembl
- 4q35.2 by Entrez Gene
- 4q35.2 by HGNC


RefSeq DNA sequence for DUX4L8 Gene
No data available for GeneHancer (GH) Regulatory Elements for DUX4L8 Gene
Proteins for DUX4L8 Gene
Protein Expression for DUX4L8 Gene
Post-translational modifications for DUX4L8 Gene
Antibody Products
- antibodies-online: Search results for available DUX2 related products ranked by validation data
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Protein Products
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- antibodies-online: Search results for available DUX2 related products ranked by validation data
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Assay Products
- antibodies-online: Search results for available DUX2 related products ranked by validation data
No data available for DME Specific Peptides for DUX4L8 Gene
Domains & Families for DUX4L8 Gene
Gene Families for DUX4L8 Gene
Suggested Antigen Peptide Sequences for DUX4L8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains and UniProtKB/Swiss-Prot for DUX4L8 Gene
Function for DUX4L8 Gene
Phenotypes for DUX4L8 Gene
- GenomeRNAi human phenotypes for DUX4L8:
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for DUX4L8 gene
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CRISPR Products
-
OriGene CRISPR knockouts for DUX4L8
- genomics-online: gRNA clones - Search results for available DUX2 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available DUX2 gene related products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DUX2 gene related products
- orf clones - Search results for available DUX2 gene related products
- Applied Biological Materials Clones for DUX4L8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for DUX4L8
-
ViGene Biosciences adenoviral particle packaged cDNA for DUX4L8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DUX4L8 gene
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L8 Gene
Localization for DUX4L8 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DUX4L8 Gene
Transcripts for DUX4L8 Gene
mRNA/cDNA for DUX4L8 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for DUX4L8
- genomics-online: gRNA clones - Search results for available DUX2 gene related products
- Applied Biological Materials CRISPR for DUX4L8
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for DUX4L8
miRNA Products
- Search ViGene Biosciences for DUX4L8
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for DUX4L8
- Browse OriGene Inhibitory RNA Products For DUX4L8
- genomics-online: shRNA clones - Search results for available DUX2 gene related products
- Search ViGene Biosciences for DUX4L8
Clone Products
- GenScript: Custom all cDNA clones Services for DUX4L8
- VectorBuilder custom plasmid, inducible vectors for DUX4L8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUX4L8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DUX2 gene related products
- orf clones - Search results for available DUX2 gene related products
- Applied Biological Materials Clones for DUX4L8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DUX4L8 Gene
NURSA nuclear receptor signaling pathways regulating expression of DUX4L8 Gene:
DUX4L8Primer Products
-
OriGene qPCR primer pairs for DUX4L8
- genomics-online: primer clones - Search results for available DUX2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUX4L8 Gene
Orthologs for DUX4L8 Gene
No data available for Orthologs for DUX4L8 Gene
Paralogs for DUX4L8 Gene
Paralogs for DUX4L8 Gene
- DUX4L5 33
- DUX4L3 33
- DUX4 33
- DUX4L2 33
- DUX4L6 33
- DUX4L7 33
- LOC102723449 33
- LOC102723495 33
- LOC102723538 33
- LOC102723472 33
- DUX4L4 33
- LOC102723518 33
- LOC102723423 33
- LOC100287823 33
Variants for DUX4L8 Gene
Additional Variant Information for DUX4L8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUX4L8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L8 Gene
Disorders for DUX4L8 Gene
No disorders were found for DUX4L8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DUX4L8 Gene
Publications for DUX4L8 Gene
- Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J … Hewitt JE (American journal of human genetics 2007) 3 58
- DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M … Chen YW (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 58
- Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M … Belayew A (Gene 2001) 3 58
- Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PMID: 10433963) Gabriëls J … Belayew A (Gene 1999) 3 58
- Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements. (PMID: 9736770) Ding H … Belayew A (Human molecular genetics 1998) 3 58
Products for DUX4L8 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for DUX4L8
- VectorBuilder custom plasmid, inducible vectors for DUX4L8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUX4L8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available DUX2 related products ranked by validation data
- antibodies-online: Search results for available DUX2 related products ranked by validation data
- antibodies-online: Search results for available DUX2 related products ranked by validation data
- Search GeneTex for Antibodies for DUX4L8
- Search GeneTex for Proteins for DUX4L8
- ViGene Biosciences adenoviral particle packaged cDNA for DUX4L8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DUX4L8 gene
- Search ViGene Biosciences for DUX4L8
- Horizon Cell Lines for DUX4L8
- genomics-online: cdna clones - Search results for available DUX2 gene related products
- orf clones - Search results for available DUX2 gene related products
- genomics-online: gRNA clones - Search results for available DUX2 gene related products
- genomics-online: primer clones - Search results for available DUX2 gene related products
- genomics-online: shRNA clones - Search results for available DUX2 gene related products
Sources for DUX4L8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (17) IUBMB
- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (114) diseasecard
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- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew