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DUX4L6 Gene(Pseudogene)

Double Homeobox 4 Like 6

GCID:
GC04P190074
GIFtS:
21
Genes Participants
UDN Logo

Aliases for DUX4L6 Gene

Aliases for DUX4L6 Gene

  • Double Homeobox 4 Like 6 2 3 5

External Ids for DUX4L6 Gene

Previous GeneCards Identifiers for DUX4L6 Gene

  • GC04P190996
  • GC04P190997
  • GC04P191016
  • GC04P191038

Summaries for DUX4L6 Gene

Entrez Gene Summary for DUX4L6 Gene

  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

GeneCards Summary for DUX4L6 Gene

DUX4L6 (Double Homeobox 4 Like 6) is a Pseudogene. An important paralog of this gene is DUX4L2.

UniProtKB/Swiss-Prot for DUX4L6 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L6 Gene

Genomics for DUX4L6 Gene

Products:

  1. Regulatory Element

Genomic Location for DUX4L6 Gene

Chromosome:
4
Start:
190,074,525 bp from pter
End:
190,075,809 bp from pter
Size:
1,285 bases
Orientation:
Plus strand

Genomic View for DUX4L6 Gene

Genes around DUX4L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUX4L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUX4L6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DUX4L6 Gene

No data available for Regulatory Elements for DUX4L6 Gene

Proteins for DUX4L6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DUX4L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ89-DU4L6_HUMAN
    Recommended name:
    Double homeobox protein 4-like protein 6
    Protein Accession:
    P0CJ89

    Protein attributes for DUX4L6 Gene

    Size:
    424 amino acids
    Molecular mass:
    44926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUX4L6 Gene

Proteomics data for DUX4L6 Gene at MOPED

Post-translational modifications for DUX4L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUX4L6 Gene

Domains & Families for DUX4L6 Gene

Gene Families for DUX4L6 Gene

HGNC:

Protein Domains for DUX4L6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DUX4L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ89

UniProtKB/Swiss-Prot:

DU4L6_HUMAN :
  • Contains 2 homeobox DNA-binding domains.
Domain:
  • Contains 2 homeobox DNA-binding domains.
genes like me logo Genes that share domains with DUX4L6: view

Function for DUX4L6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DUX4L6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for DUX4L6 Gene

GenomeRNAi human phenotypes for DUX4L6:
genes like me logo Genes that share phenotypes with DUX4L6: view

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L6 Gene

Localization for DUX4L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUX4L6 Gene

Nucleus.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUX4L6 Gene

Pathways & Interactions for DUX4L6 Gene

SuperPathways for DUX4L6 Gene

PathCards logoMore details on SuperPathways for DUX4L6
No Data Available

Interacting Proteins for DUX4L6 Gene

Gene Ontology (GO) - Biological Process for DUX4L6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DUX4L6 Gene

Drugs & Compounds for DUX4L6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DUX4L6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DUX4L6 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L6 Gene

No ASD Table

Relevant External Links for DUX4L6 Gene

GeneLoc Exon Structure for
DUX4L6
ECgene alternative splicing isoforms for
DUX4L6

Expression for DUX4L6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DUX4L6 Gene

mRNA expression in normal human tissues for DUX4L6 Gene
mRNA expression by BioGPS for DUX4L6 Gene

SOURCE GeneReport for Unigene cluster for DUX4L6 Gene Hs.723089

genes like me logo Genes that share expression patterns with DUX4L6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DUX4L6 Gene

Orthologs for DUX4L6 Gene

Evolution for DUX4L6 Gene

ENSEMBL:
Gene Tree for DUX4L6 (if available)
TreeFam:
Gene Tree for DUX4L6 (if available)

No data available for Orthologs for DUX4L6 Gene

Paralogs for DUX4L6 Gene

Paralogs for DUX4L6 Gene

(14) SIMAP similar genes for DUX4L6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUX4L6: view

Variants for DUX4L6 Gene

Structural Variations from Database of Genomic Variants (DGV) for DUX4L6 Gene

Variant ID Type Subtype PubMed ID
nsv428243 CNV Gain 18775914
esv28562 CNV Gain+Loss 19812545
nsv8752 CNV Gain+Loss 18304495
nsv896428 CNV Gain 21882294
nsv442214 CNV CNV 18776908
dgv4n31 CNV Duplication 19718026
nsv471357 CNV Duplication 19718026
nsv482152 CNV Gain 20164927
nsv10641 CNV Loss 18304495
nsv471487 CNV Duplication 19718026
esv23426 CNV Gain+Loss 19812545

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for DUX4L6 Gene

Disorders for DUX4L6 Gene

No disorders were found for DUX4L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DUX4L6 Gene

Publications for DUX4L6 Gene

  1. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J. … Hewitt J.E. (Am. J. Hum. Genet. 2007) 3 67
  2. The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. (PMID: 17588759) Kowaljow V. … Rosa A.L. (Neuromuscul. Disord. 2007) 3
  3. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M. … Chen Y.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  4. Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M.-C. … Belayew A. (Gene 2001) 3
  5. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PMID: 10433963) Gabrieels J. … Belayew A. (Gene 1999) 3

Products for DUX4L6 Gene

Sources for DUX4L6 Gene

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