Aliases for DUX4L6 Gene
External Ids for DUX4L6 Gene
- HGNC: 37265
- Entrez Gene: 653544
- Ensembl: ENSG00000281058
- UniProtKB: P0CJ89
Previous GeneCards Identifiers for DUX4L6 Gene
- GC04P190996
- GC04P190997
- GC04P191016
- GC04P191038
Summaries for DUX4L6 Gene
-
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]
GeneCards Summary for DUX4L6 Gene
DUX4L6 (Double Homeobox 4 Like 6) is a Pseudogene. An important paralog of this gene is DUX4.
UniProtKB/Swiss-Prot for DUX4L6 Gene
-
May be involved in transcriptional regulation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L6 Gene
Genomics for DUX4L6 Gene
Regulatory Element Products
Genomic Location for DUX4L6 Gene
- Chromosome:
- 4
- Start:
- 190,074,525 bp from pter
- End:
- 190,075,809 bp from pter
- Size:
- 1,285 bases
- Orientation:
- Plus strand
Genomic View for DUX4L6 Gene
Genes around DUX4L6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q35.2 by Ensembl
- 4q35.2 by Entrez Gene
- 4q35.2 by HGNC
DUX4L6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DUX4L6 Gene
No data available for Regulatory Elements for DUX4L6 Gene
Proteins for DUX4L6 Gene
-
Protein details for DUX4L6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CJ89-DU4L6_HUMAN
- Recommended name:
- Double homeobox protein 4-like protein 6
- Protein Accession:
- P0CJ89
Protein attributes for DUX4L6 Gene
- Size:
- 424 amino acids
- Molecular mass:
- 44926 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for DUX4L6 Gene
Antibody Products
- Search GeneTex for Antibodies for DUX4L6
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DUX4L6
- Origene Custom Protein Services for DUX4L6
- Search GeneTex for Proteins for DUX4L6
No data available for DME Specific Peptides for DUX4L6 Gene
Domains & Families for DUX4L6 Gene
Gene Families for DUX4L6 Gene
Protein Domains for DUX4L6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DUX4L6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DUX4L6 Gene
Function for DUX4L6 Gene
Molecular function for DUX4L6 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes for DUX4L6 Gene
- GenomeRNAi human phenotypes for DUX4L6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUX4L6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DUX4L6 gene
- Search ViGene Biosciences for DUX4L6
miRNA Products
- Search ViGene Biosciences for DUX4L6
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DUX4L6
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Clone Products
- GenScript: Custom all cDNA clones Services for DUX4L6
- VectorBuilder custom plasmid, inducible vectors for DUX4L6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for DUX4L6
-
ViGene Biosciences adenoviral particle packaged cDNA for DUX4L6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DUX4L6 gene
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L6 Gene
Localization for DUX4L6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DUX4L6 Gene
- Nucleus.
No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUX4L6 Gene
Transcripts for DUX4L6 Gene
mRNA/cDNA for DUX4L6 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
miRNA Products
- Search ViGene Biosciences for DUX4L6
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DUX4L6
- Browse OriGene Inhibitory RNA Products For DUX4L6
- Search ViGene Biosciences for DUX4L6
Clone Products
- GenScript: Custom all cDNA clones Services for DUX4L6
- VectorBuilder custom plasmid, inducible vectors for DUX4L6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUX4L6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for DUX4L6 Gene
NURSA nuclear receptor signaling pathways regulating expression of DUX4L6 Gene:
DUX4L6SOURCE GeneReport for Unigene cluster for DUX4L6 Gene:
Hs.723089Primer Products
-
OriGene qPCR primer pairs for DUX4L6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUX4L6 Gene
Orthologs for DUX4L6 Gene
No data available for Orthologs for DUX4L6 Gene
Paralogs for DUX4L6 Gene
Paralogs for DUX4L6 Gene
- DUX4L5 34
- DUX4 34
- DUX4L3 34
- DUX4L2 34
- DUX4L7 34
- DUX2 34
- DUX4L4 34
- LOC102723449 34
- LOC102723472 34
- LOC102723538 34
- LOC102723495 34
- LOC102723423 34
- LOC102723518 34
- LOC100287823 34
(14) SIMAP similar genes for DUX4L6 Gene using alignment to 1 proteins:
Variants for DUX4L6 Gene
Relevant External Links for DUX4L6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DUX4L6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L6 Gene
Disorders for DUX4L6 Gene
No disorders were found for DUX4L6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DUX4L6 Gene
Publications for DUX4L6 Gene
- The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. (PMID: 17588759) Kowaljow V. … Rosa A.L. (Neuromuscul. Disord. 2007) 3 64
- Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J. … Hewitt J.E. (Am. J. Hum. Genet. 2007) 3 64
- DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M. … Chen Y.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
- Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M.-C. … Belayew A. (Gene 2001) 3 64
Products for DUX4L6 Gene
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- Search GeneTex for Antibodies for DUX4L6
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- ViGene Biosciences adenoviral particle packaged cDNA for DUX4L6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DUX4L6 gene
- Search ViGene Biosciences for DUX4L6
- Horizon Cell Lines for DUX4L6
- Cyagen custom Knockout/knockin (KOKI) mouse models for DUX4L6
- VectorBuilder custom plasmid, inducible vectors for DUX4L6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DUX4L6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DUX4L6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
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- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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