DUX4L3 Gene
protein-coding GIFtS: 27
GCID: GC04P191030
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double homeobox 4 like 3
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Aliases
for DUX4L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Double Homeobox 4 Like 31 2 | | Double Homeobox Protein 4-Like Protein 32 |
Export aliases for DUX4L3 gene to outside databasesPrevious GC identifers: GC04P191009 GC04P191013 GC04P191020 GC04P191025 |
Summaries
for DUX4L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DU4L3_HUMAN, P0CJ86Function: May be involved in transcriptional regulation (By similarity)
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Genomic Views
for DUX4L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DUX4L3
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUX4L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.2 Ensembl cytogenetic band: 4q35.2 HGNC cytogenetic band: 4q35.2DUX4L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P191030: view genomic region
(about GC identifiers)
Start:
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191,008,560 bp from pter |
End:
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191,010,176 bp from pter |
Size:
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1,617 bases |
Orientation:
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plus strand |
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Proteins
for DUX4L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DU4L3_HUMAN, P0CJ86 (See
protein sequence)Recommended Name: Double homeobox protein 4-like protein 3 Size: 424 amino acids; 44926 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for DUX4L3: NX_P0CJ86
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CJ86
DUX4L3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001157939.1
ENSEMBL proteins: ENSP00000451859 ENSP00000451798
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
DUX4L3 for ontologies About GeneDecksing
DUX4L3 Antibody Products:
Assay Products for DUX4L3: |
Protein
Domains /
Families
for DUX4L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUX4L3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0CJ86ProtoNet protein and cluster: P0CJ86 UniProtKB/Swiss-Prot: DU4L3_HUMAN, P0CJ86Similarity: Contains 2 homeobox DNA-binding domains |
Function
for DUX4L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DU4L3_HUMAN, P0CJ86Function: May be involved in transcriptional regulation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4L3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4L3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUX4L3 (NM_001164467) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUX4L3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DUX4L3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
DUX4L3 for ontologies About GeneDecksing
|
Pathways & Interactions
for DUX4L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUX4L3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
DUX4L3 for ontologies About GeneDecksing
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Drugs & Compounds
for DUX4L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUX4L3
Search CenterWatch for drugs/clinical trials and news about DUX4L3 / DU4L3
|
Transcripts
for DUX4L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUX4L3 gene: NM_001164467.1 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000557656 ENST00000554690(uc011clk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4L3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4L3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DUX4L3 (NM_001164467) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUX4L3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DUX4L3 |
GeneLoc Exon Structure
|
Expression
for DUX4L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUX4L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for DUX4L3
SABiosciences Custom PCR Arrays for DUX4L3
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DUX4L3 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4L3 |
Orthologs
for DUX4L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for DUX4L3 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
mxtx26mxtx16 |
mix-type homeobox gene 1 |
20(a)19(a) |
many ↔ manymany ↔ many |
12(30784435-30785976) 13(21796925-21800415) |
ENSEMBL Gene Tree for DUX4L3 (if available)
TreeFam Gene Tree for DUX4L3 (if available) |
Paralogs
for DUX4L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUX4L3 gene
- DUX4L21 2 DUX4L51 2 DUX41 2 DUX4L61 2 DUX4L71 2 DUX4L41 2 DUX2 ENSG000002143252
- DUXA2
14 SIMAP similar genes for DUX4L3 using alignment to 1 protein entry: DU4L3_HUMAN:DUX4L2 DUX4L5 DUX4L6 DUX4L7 DUX4 DUX4L4
DUX4L9 DUX2 DUX5 DUX1 HPX-2 DUX3
DUXA POU6F1
DUX4L3 for paralogs About GeneDecksing
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Genomic Variants
for DUX4L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DUX4L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUX4L3 for disorders About GeneDecksing
2  diseases for DUX4L3: About MalaCardsfacioscapulohumeral muscular dystrophy muscular dystrophy
Export disorders for DUX4L3 gene to outside databases
|
Publications
for DUX4L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUX4L3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUX4L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PubMed id 17668377)1 Clapp J....Hewitt J.E. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PubMed id 10433963)1 Gabrieels J.... Belayew A. (1999)
- Characterization of a tandemly repeated 3.3kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35. (PubMed id 7739628)1 Lee J.... Arahata K. (1995)
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External Searches for DUX4L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DUX4L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUX4L3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUX4L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUX4L3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DUX4L3 gene:
Search GeneIP for patents involving DUX4L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUX4L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUX4L3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUX4L3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4L3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUX4L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4L3 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4L3 |
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| | | | Search Tocris compounds for DUX4L3 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for DUX4L3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DUX4L3 |
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