Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUX4L2 Gene

Aliases for DUX4L2 Gene

  • Double Homeobox 4 Like 2 2 3 5
  • Double Homeobox Protein 4-Like Protein 2 3
  • DUX4 3

External Ids for DUX4L2 Gene

Previous GeneCards Identifiers for DUX4L2 Gene

  • GC04P191012
  • GC04P191014
  • GC04P191021
  • GC04P191026
  • GC04P191031
  • GC04P191036
  • GC04P191044

Summaries for DUX4L2 Gene

Entrez Gene Summary for DUX4L2 Gene

  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

GeneCards Summary for DUX4L2 Gene

DUX4L2 (Double Homeobox 4 Like 2) is a Pseudogene. An important paralog of this gene is DUX4L6.

UniProtKB/Swiss-Prot for DUX4L2 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX4L2 Gene

Genomics for DUX4L2 Gene

Regulatory Elements for DUX4L2 Gene

Enhancers for DUX4L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F190111 1.2 Ensembl ENCODE 0.3 +20.6 20553 0.9 DUX4L2 DUX4
GH04F190122 1 ENCODE 0.3 +32.0 32006 0.2 DUX4L2 DUX4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DUX4L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUX4L2 Gene

Chromosome:
4
Start:
190,091,005 bp from pter
End:
190,092,289 bp from pter
Size:
1,285 bases
Orientation:
Plus strand

Genomic View for DUX4L2 Gene

Genes around DUX4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUX4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUX4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUX4L2 Gene

Proteins for DUX4L2 Gene

  • Protein details for DUX4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CJ85-DU4L2_HUMAN
    Recommended name:
    Double homeobox protein 4-like protein 2
    Protein Accession:
    P0CJ85

    Protein attributes for DUX4L2 Gene

    Size:
    424 amino acids
    Molecular mass:
    44926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUX4L2 Gene

Post-translational modifications for DUX4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DUX4L2 Gene

Domains & Families for DUX4L2 Gene

Gene Families for DUX4L2 Gene

Protein Domains for DUX4L2 Gene

Suggested Antigen Peptide Sequences for DUX4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CJ85

UniProtKB/Swiss-Prot:

DU4L2_HUMAN :
  • Contains 2 homeobox DNA-binding domains.
Domain:
  • Contains 2 homeobox DNA-binding domains.
genes like me logo Genes that share domains with DUX4L2: view

Function for DUX4L2 Gene

Molecular function for DUX4L2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for DUX4L2 Gene

GenomeRNAi human phenotypes for DUX4L2:
genes like me logo Genes that share phenotypes with DUX4L2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUX4L2 Gene

Localization for DUX4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUX4L2 Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DUX4L2 Gene

Pathways & Interactions for DUX4L2 Gene

SuperPathways for DUX4L2 Gene

No Data Available

Interacting Proteins for DUX4L2 Gene

Gene Ontology (GO) - Biological Process for DUX4L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DUX4L2 Gene

Transcripts for DUX4L2 Gene

mRNA/cDNA for DUX4L2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUX4L2 Gene

No ASD Table

Relevant External Links for DUX4L2 Gene

GeneLoc Exon Structure for
DUX4L2
ECgene alternative splicing isoforms for
DUX4L2

Expression for DUX4L2 Gene

mRNA expression in normal human tissues for DUX4L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUX4L2 Gene:

DUX4L2

SOURCE GeneReport for Unigene cluster for DUX4L2 Gene:

Hs.714689
genes like me logo Genes that share expression patterns with DUX4L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DUX4L2 Gene

Orthologs for DUX4L2 Gene

Evolution for DUX4L2 Gene

ENSEMBL:
Gene Tree for DUX4L2 (if available)
TreeFam:
Gene Tree for DUX4L2 (if available)

No data available for Orthologs for DUX4L2 Gene

Paralogs for DUX4L2 Gene

Paralogs for DUX4L2 Gene

(17) SIMAP similar genes for DUX4L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DUX4L2: view

Variants for DUX4L2 Gene

Relevant External Links for DUX4L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUX4L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DUX4L2 Gene

Disorders for DUX4L2 Gene

No disorders were found for DUX4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DUX4L2 Gene

Publications for DUX4L2 Gene

  1. RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy. (PMID: 19359275) Snider L. … Tapscott S.J. (Hum. Mol. Genet. 2009) 3 64
  2. The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. (PMID: 17588759) Kowaljow V. … Rosa A.L. (Neuromuscul. Disord. 2007) 3 64
  3. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. (PMID: 17668377) Clapp J. … Hewitt J.E. (Am. J. Hum. Genet. 2007) 3 64
  4. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PMID: 17984056) Dixit M. … Chen Y.W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for DUX4L2 Gene

Sources for DUX4L2 Gene

Content
Loading form....