DUX4 Gene
protein-coding GIFtS: 45
GCID: GC04P191005
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double homeobox 4
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Aliases for DUX4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Double Homeobox 41 2 | | Double Homeobox Protein 102 3 | | Double Homeobox Protein 4/102 3 | | DUX102 3 | | Double Homeobox Protein 42 | | Double Homeobox Protein DUX102 |
Export aliases for DUX4 gene to outside databasesPrevious GC identifers: GC04P192017 GC10P134609 GC04P191585 GC04P191697 GC04P191683 GC04P191376 GC04P191232 GC04P191240 GC04P191251 GC04P191254 GC04P191257 GC04P191260 |
Summaries for DUX4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DUX4: This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat ispolymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has anopen reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals.There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experimentsindicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptionalactivator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatelliterepeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2Function: Involved in transcriptional regulation
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Genomic Views for DUX4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NT_016354.19
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for DUX4 Other transcription factors
Search SABiosciences Chromatin IP Primers for DUX4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35 Ensembl cytogenetic band: 4q35.2 HGNC cytogenetic band: 4q35.2DUX4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P191005: view genomic region
(about GC identifiers)
Start:
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191,005,267 bp from pter |
End:
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191,007,067 bp from pter |
Size:
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1,801 bases |
Orientation:
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plus strand |
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Proteins for DUX4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2 (See
protein sequence)Recommended Name: Double homeobox protein 4 Size: 424 amino acids; 44940 Da
Subunit: May exist as a monomer or a dimer
Subcellular location: Nucleus. Note=Actively transported through the nuclear pore complex (NPC)
Miscellaneous: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found onthe short arms of all acrocentric chromosomes as well as on several other chromosomesExplore the universe of human proteins at neXtProt for DUX4: NX_Q9UBX2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBX2 DUX4 Protein expression data from MOPED and PaxDb: -- REFSEQ proteins: NP_149418.3 ENSEMBL proteins: ENSP00000451207 ENSP00000451304 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
DUX4 for ontologies About GeneDecksing
DUX4 Antibody Products: Assay Products for DUX4: |
Protein
Domains / Families for DUX4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUX4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBX2ProtoNet protein and cluster: Q9UBX2 1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature
UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2Domain: Both homebox domains confer nuclear targetingSimilarity: Belongs to the paired homeobox familySimilarity: Contains 2 homeobox DNA-binding domains |
Function for DUX4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2Function: Involved in transcriptional regulation Genatlas biochemistry entry for DUX4:double homeo box protein 4 in the partially deleted D4Z4 locus (FSHD)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUX4 (NM_033178) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUX4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
DUX4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DUX4:
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Pathways & Interactions for DUX4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUX4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
DUX4 for ontologies About GeneDecksing
|
Drugs & Compounds for DUX4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DUX4 Search CenterWatch for drugs/clinical trials and news about DUX4 
|
Transcripts for DUX4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DUX4 gene: NM_033178.2 Unigene Cluster for DUX4: Double homeobox 4 Hs.553518 Unigene Representative Sequence: NM_0331782 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000554285 ENST00000556625(uc010ist.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUX4 (NM_033178) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUX4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4  |
1 AceView cDNA sequence: NM_033178 GeneLoc Exon Structure
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Expression for DUX4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUX4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image Genevestigator expression for DUX4
SOURCE GeneReport for Unigene cluster: Hs.553518 UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2Tissue specificity: Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where itmay be toxic to cells SABiosciences Custom PCR Arrays for DUX4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUX4 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DUX4 | |  | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4 |
Orthologs for DUX4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DUX4 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
zebrafish (Danio rerio) |
Actinopterygii |
mxtx26mxtx16 |
mix-type homeobox gene 1 |
20(a)19(a) |
many ↔ manymany ↔ many |
12(30784435-30785976) 13(21796925-21800415) |
ENSEMBL Gene Tree for DUX4 (if available) TreeFam Gene Tree for DUX4 (if available)  |
Paralogs for DUX4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DUX4 gene
- DUX4L21 2 DUX4L51 2 DUX4L61 2 DUX4L31 2 DUX4L71 2 DUX4L41 2 DUX2 ENSG000002143252
- DUXA2
18/24 SIMAP similar genes for DUX4 using alignment to 25 protein entries: DUX4_HUMAN (see all proteins)
(see all similar genes):DUX4L2 DUX4L3 DUX4L5 DUX4L6 DUX4L7 DUX4L4 DUX4L9 DUX2 DUX5 DUX1 DUX3 HPX-2 CIC/DUX4 fusion LHX3 MSX1 PRRX1 PITX2 PAX6
DUX4 for paralogs About GeneDecksing
|
Genomic Variants for DUX4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 20 variations for DUX4 15/20 CNVs (see all 20): 65825 80737 75476 32686 71205 92763 71200 75474 85570 68911 37652 30527 80738 92759 80735 Human Gene Mutation Database (HGMD): DUX4
 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases for DUX4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUX4 for disorders About GeneDecksing
OMIM gene information: 606009
OMIM disorders: --
UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
Defects in DUX4 may be the cause of facioscapulohumeral muscular dystrophy 1 (FSHD1) [MIM:158900]. Adegenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, andshoulder girdle. The onset of symptoms usually occurs in the first or second decade of life. Affected individualsusually present with impairment of upper extremity elevation. This tends to be followed by facial weakness, primarilyinvolving the orbicularis oris and orbicularis oculi muscles. Note=The disease is caused by deletion of an integralnumber of units of a 3.3-kb tandem repeats, termed D4Z4 macrosatellite, located on chromosome 4q35. In unaffectedsubjects, the D4Z4 array consists of 11-150 repeats, while in FSHD1 patients, the array is reduced to 1-10 repeats(PubMed:19320656). DUX4 is located in D4Z4 macrosatellite which is epigenetically repressed in somatic tissues. D4Z4chromatin relaxation in FSHD1 results in inefficient epigenetic repression of DUX4 and a variegated pattern of DUX4protein expression in a subset of skeletal muscle nuclei. Ectopic expression of DUX4 in skeletal muscle activates theexpression of stem cell and germline genes, and, when overexpressed in somatic cells, DUX4 can ultimately lead to celldeath 7 diseases for DUX4: About MalaCardsfacioscapulohumeral muscular dystrophy muscular dystrophy hepatocellular carcinoma cervical cancer cervicitis sarcoma carcinoma Genetic Association Database (GAD): DUX4 Human Genome Epidemiology (HuGE) Navigator: DUX4 (1 document) Export disorders for DUX4 gene to outside databases
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Publications for DUX4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUX4 gene, integrated from 9 sources (see all 26): (articles sorted by number of sources associating them with DUX4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Intracellular trafficking and dynamics of double homeodomain proteins. (PubMed id 15709750)1, 2, 9 Oestlund C.... Worman H.J. (2005)
- Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PubMed id 10433963)1, 2 Gabrieels J.... Belayew A. (1999)
- DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PubMed id 17984056)1, 9 Dixit M....Chen Y.W. (2007)
- Asymmetric bidirectional transcription from the FSHD-c ausing D4Z4 array modulates DUX4 production. (PubMed id 22536400)1 Block G.J....Miller D.G. (2012)
- Correlation analysis of clinical parameters with epige netic modifications in the DUX4 promoter in FSHD. (PubMed id 22522912)1 Balog J....van der Maarel S.M. (2012)
- DUX4 activates germline genes, retroelements, and immu ne mediators: implications for facioscapulohumeral dystrophy. (PubMed id 22209328)1 Geng L.N....Tapscott S.J. (2012)
- Immunodetection of human double homeobox 4. (PubMed id 21529284)1 Geng L.N....Tapscott S.J. (2011)
- The FSHD atrophic myotube phenotype is caused by DUX4 expression. (PubMed id 22053214)1 Vanderplanck C....Belayew A. (2011)
- A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy. (PubMed id 20724583)1 Lemmers R.J....van der Maarel S.M. (2010)
- Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. (PubMed id 21060811)1 Snider L....Miller D.G. (2010)
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External Searches for DUX4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing DUX4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUX4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUX4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DUX4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DUX4 gene: Search GeneIP for patents involving DUX4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for DUX4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for DUX4 | | OriGene shRNA RFP for DUX4 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUX4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUX4 | | OriGene Protein Over-expression Lysate for DUX4 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for DUX4 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX4 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for DUX4 | | OriGene Custom Protein Services for DUX4 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUX4 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUX4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUX4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4 | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4 |
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| | | Search Tocris compounds for DUX4 |
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 | | DUX4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | ThermoFisher Antibody for DUX4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4 |
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