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DUX4 Gene

protein-coding   GIFtS: 41
GCID: GC04P191005

Double Homeobox 4

  See DUX4-related diseases
at
MalaCards
 

Aliases
for DUX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Double Homeobox 41 2
Double Homeobox Protein 102 3
Double Homeobox Protein 4/102 3
DUX102 3
Double Homeobox Protein 42

External Ids:    HGNC: 30821   Entrez Gene: 229472   Ensembl: ENSG000002583897   OMIM: 6060095   UniProtKB: Q9UBX23   

Export aliases for DUX4 gene to outside databases

Previous GC identifers: GC04P192017 GC10P134609 GC04P191585 GC04P191697 GC04P191683 GC04P191376 GC04P191232 GC04P191240 GC04P191251 GC04P191254 GC04P191257 GC04P191260


Summaries
for DUX4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUX4 Gene:
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is
polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit
has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in
other mammals. There is no evidence for transcription of this gene from standard cDNA libraries, however, RT-PCR
and in vitro expression experiments indicate that the ORF is transcribed. The encoded protein has been reported
to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID
5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy
(FSHD). (provided by RefSeq, May 2013)

GeneCards Summary for DUX4 Gene:
DUX4 (double homeobox 4) is a protein-coding gene. Diseases associated with DUX4 include facioscapulohumeral muscular dystrophy, and embryonal rhabdomyosarcoma. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DUX4L3.

UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
Function: Involved in transcriptional regulation. May regulate microRNA (miRNA) expression




Genomic Views
for DUX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DUX4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DUX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

DUX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUX4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P191005:  view genomic region     (about GC identifiers)

Start:
 191,005,267 bp from pter      End:
 191,007,077 bp from pter
Size:
 1,811 bases      Orientation:
 plus strand

1 alternative location:
Chr4+,NW_003571034 177,042-178,658     

Proteins
for DUX4 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2 (See protein sequence)
Recommended Name: Double homeobox protein 4  
Size: 424 amino acids; 44940 Da
Subunit: May exist as a monomer or a dimer
Miscellaneous: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome
found on the short arms of all acrocentric chromosomes as well as on several other chromosomes

Explore the universe of human proteins at neXtProt for DUX4: NX_Q9UBX2

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • REFSEQ proteins: NP_149418.4  
    ENSEMBL proteins: 
     ENSP00000473851   ENSP00000451207   ENSP00000451304  

    DUX4 Human Recombinant Protein Products:

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    Novus Biologicals DUX4 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUX4

         		 Search eBioscience for Proteins for DUX4 

         		antibodies-online proteins for DUX4 (2 products) 

         		antibodies-online peptides for DUX4

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    antibodies-online antibodies for DUX4 (57 products) 

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    antibodies-online kits for DUX4 

    Domains /
    Families
    for DUX4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    3 InterPro protein domains:
     IPR000047 HTH_motif
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UBX2

    ProtoNet protein and cluster: Q9UBX2

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
    Domain: Both homeobox domains confer nuclear targeting
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 2 homeobox DNA-binding domains


    Find genes that share domains with DUX4           About GenesLikeMe


    Function
    for DUX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUX4_HUMAN, Q9UBX2
    Function: Involved in transcriptional regulation. May regulate microRNA (miRNA) expression

         Genatlas biochemistry entry for DUX4:
    double homeo box protein 4 in the partially deleted D4Z4 locus (FSHD)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    Find genes that share ontologies with DUX4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DUX4:
     Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DUX4

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUX4


    Localization
    for DUX4 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUX4_HUMAN, Q9UBX2: Nucleus. Note=Actively transported through the nuclear pore complex (NPC)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with DUX4           About GenesLikeMe


    Pathways & Interactions
    for DUX4 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUX4
    Interactions:

        GeneGlobe Interaction Network for DUX4

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with DUX4           About GenesLikeMe



    Drugs & Compounds
    for DUX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUX4



    Transcripts
    for DUX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUX4 gene: 
    NM_033178.4  

    Unigene Cluster for DUX4:

    Double homeobox 4
    Hs.553518
    Unigene Representative Sequence: NM_033178
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000605758 ENST00000554285 ENST00000556625(uc010ist.1)
    miRNA
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for DUX4
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DUX4
      Search QuantiTect SYBR Green Assays in human, mouse, rat DUX4
      QuantiFast Probe-based Assays in human, mouse, rat DUX4

    1 AceView cDNA sequence:

    NM_033178 

    GeneLoc Exon Structure


    Expression
    for DUX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DUX4 Expression
    About this image

    DUX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3:  --

    SOURCE GeneReport for Unigene cluster: Hs.553518

    UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
    Tissue specificity: Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where
    it may be toxic to cells

        Custom PCR Arrays for DUX4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUX4

    Orthologs
    for DUX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for DUX4 (if available)
    TreeFam Gene Tree for DUX4 (if available)

    Paralogs
    for DUX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUX4 gene
    DUX4L21 2  DUX4L61 2  DUX4L31 2  DUX4L51 2  DUX4L71 2  DUX2  DUX4L41 2  LOC102723538  
    LOC102723495  LOC102723449  LOC102723472  LOC102723423  LOC102723518  LOC100287823  ENSG000002143252  DUXA2  
    Selected SIMAP similar genes for DUX4 using alignment to 25 protein entries:     DUX4_HUMAN (see all proteins) (see all similar genes):
    DUX4L2    DUX4L3    DUX4L5    DUX4L6    DUX4L7    DUX4L4
    DUX4L9    DUX2    DUX5    DUX1    DUX3    HPX-2
    CIC/DUX4 fusion    LHX3    MSX1    PITX2    TPRX2P    MNX1

    Find genes that share paralogs with DUX4           About GenesLikeMe



    Genomic Variants
    for DUX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    TryGeneCards Plus    		Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DUX4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4n31CNV Duplication19718026
    nsv471357CNV Duplication19718026
    nsv471487CNV Duplication19718026
    nsv10641CNV Loss18304495
    nsv428243CNV Gain18775914
    nsv896428CNV Gain21882294
    nsv482152CNV Gain20164927
    esv23426CNV Gain+Loss19812545
    esv28562CNV Gain+Loss19812545
    nsv8752CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): DUX4
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DUX4
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    Disorders / Diseases
    for DUX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		 OMIM gene information: 606009    OMIM disorders: --

    UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
  • Facioscapulohumeral muscular dystrophy 1 (FSHD1) [MIM:158900]: A degenerative muscle disease
    characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The
    onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with
    impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the
    orbicularis oris and orbicularis oculi muscles. Note=The gene represented in this entry is involved in disease
    pathogenesis. The disease is caused by deletion of an integral number of units of a 3.3-kb tandem repeats, termed
    D4Z4 macrosatellite, located on chromosome 4q35. In unaffected subjects, the D4Z4 array consists of 11-150
    repeats, while in FSHD1 patients, the array is reduced to 1-10 repeats (PubMed:19320656). DUX4 is located in D4Z4
    macrosatellite which is epigenetically repressed in somatic tissues. D4Z4 chromatin relaxation in FSHD1 results
    in inefficient epigenetic repression of DUX4 and a variegated pattern of DUX4 protein expression in a subset of
    skeletal muscle nuclei. Ectopic expression of DUX4 in skeletal muscle activates the expression of stem cell and
    germline genes, and, when overexpressed in somatic cells, DUX4 can ultimately lead to cell death

    • 2 diseases for DUX4:    
    About MalaCards
    facioscapulohumeral muscular dystrophy    embryonal rhabdomyosarcoma


    Find genes that share disorders with DUX4           About GenesLikeMe

    Genetic Association Database (GAD): DUX4
    Human Genome Epidemiology (HuGE) Navigator: DUX4 (1 document)

    Export disorders for DUX4 gene to outside databases

    Publications
    for DUX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUX4 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with DUX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Intracellular trafficking and dynamics of double homeodomain proteins. (PubMed id 15709750)1, 2, 9 Oestlund C.... Worman H.J. (Biochemistry 2005)
    2. Polymorphism of the D4Z4 locus associated with facioscapulohumeral muscular dystrophy 1A in Shanghai population. (PubMed id 16086272)1, 4 Zhang Y.Z....Urtizberea J.A. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    3. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PubMed id 10433963)1, 2 Gabrieels J.... Belayew A. (Gene 1999)
    4. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PubMed id 17984056)1, 9 Dixit M....Chen Y.W. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. Intrinsic epigenetic regulation of the D4Z4 macrosatellite repeat in a transgenic mouse model for FSHD. (PubMed id 23593020)1 Krom Y.D....van der Maarel S.M. (PLoS Genet. 2013)
    6. A focal domain of extreme demethylation within D4Z4 in FSHD2. (PubMed id 23284062)1 Hartweck L.M....Kyba M. (Neurology 2013)
    7. Expression of the human FSHD-linked DUX4 gene induces neurogenesis during differentiation of murine embryonic stem cells. (PubMed id 23560660)1 Dandapat A....Kyba M. (Stem Cells Dev. 2013)
    8. Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients. (PubMed id 24145033)2 Dmitriev P.... Vassetzky Y.S. (J. Biol. Chem. 2013)
    9. DUX4 differentially regulates transcriptomes of human rhabdomyosarcoma and mouse C2C12 cells. (PubMed id 23717650)1 Sharma V....Chen Y.W. (PLoS ONE 2013)
    10. DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy? (PubMed id 23206257)1 Tassin A....Belayew A. (J. Cell. Mol. Med. 2013)

    External Searches for DUX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DUX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22947 HGNC: 3082 AceView: DUX4 Ensembl:ENSG00000258389 euGenes: HUgn22947
    ECgene: DUX4 H-InvDB: DUX4

    Other Databases showing DUX4 gene

    (According to HUGE)
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    Specialized Databases showing DUX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DUX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for DUX4 gene:
    Search GeneIP for patents involving DUX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DUX4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

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     EMD Millipore Mono- and Polyclonal Antibodies for the study of DUX4
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DUX4   OriGene RNAi products in human, mouse, rat for DUX4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DUX4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DUX4  
     OriGene qSTAR qPCR primer pairs in human, mouse for DUX4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DUX4   OriGene Custom Protein Services for DUX4  

         		 
     Block miRNA regulation of human, mouse, rat DUX4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DUX4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUX4 Predesigned siRNA for gene silencing in human, mouse, rat DUX4
     QuantiFast Probe-based Assays in human, mouse, rat DUX4 Search QuantiTect SYBR Green Assays in human, mouse, rat DUX4
     Custom PCR Arrays for DUX4 Search Chromatin IP Primers for DUX4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DUX4  GeneGlobe Interaction Network for DUX4
     Search Regulatory tfbs for DUX4
     GenScript Custom Purified and Recombinant Proteins Services for DUX4 GenScript cDNA clones with any tag delivered in your preferred vector for DUX4
     GenScript Custom Assay Services for DUX4 GenScript Custom overexpressing Cell Line Services for DUX4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DUX4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DUX4 antibodies
     DUX4 lysates
     Search for Antibodies for DUX4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DUX4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DUX4
     Antibodies for DUX4
     ELISAs for DUX4
     CLIAs for DUX4



     Browse ESI BIO Cell Lines and PureStem Progenitors for DUX4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUX4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DUX4
     Browse SwitchGear Promoter luciferase reporter plasmids for DUX4
     ThermoFisher Antibody for DUX4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4
     Browse compounds at ApexBio
     Search Addgene for plasmids for DUX4
      Search eBioscience for proteins for DUX4
      Search eBioscience for elisas for DUX4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DUX4
     antibodies-online antibodies for DUX4 (57 products)
     antibodies-online kits for DUX4
     antibodies-online peptides for DUX4
     antibodies-online proteins for DUX4 (2 products)
           
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