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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUX4 Gene

protein-coding   GIFtS: 43
GCID: GC04P191005

Double Homeobox 4
  See related diseases
at
MalaCards
 

Aliases
for DUX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Double Homeobox 41 2
Double Homeobox Protein 102 3
Double Homeobox Protein 4/102 3
DUX102 3
Double Homeobox Protein 42

External Ids:    HGNC: 30821   Entrez Gene: 229472   Ensembl: ENSG000002583897   OMIM: 6060095   UniProtKB: Q9UBX23   

Export aliases for DUX4 gene to outside databases

Previous GC identifers: GC04P192017 GC10P134609 GC04P191585 GC04P191697 GC04P191683 GC04P191376 GC04P191232 GC04P191240 GC04P191251 GC04P191254 GC04P191257 GC04P191260


Summaries
for DUX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUX4 Gene:
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is
polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit
has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in
other mammals. There is no evidence for transcription of this gene from standard cDNA libraries, however, RT-PCR
and in vitro expression experiments indicate that the ORF is transcribed. The encoded protein has been reported
to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID
5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy
(FSHD). (provided by RefSeq, May 2013)

GeneCards Summary for DUX4 Gene: 
DUX4 (double homeobox 4) is a protein-coding gene. Diseases associated with DUX4 include facioscapulohumeral muscular dystrophy, and muscular dystrophy. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DUX4L3.

UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
Function: Involved in transcriptional regulation




Genomic Views
for DUX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DUX4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DUX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

DUX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUX4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P191005:  view genomic region     (about GC identifiers)

Start:
 191,005,267 bp from pter      End:
 191,007,077 bp from pter
Size:
 1,811 bases      Orientation:
 plus strand

1 alternative location:
Chr4+,NW_003571034 177,042-178,658     

Proteins
for DUX4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2 (See protein sequence)
Recommended Name: Double homeobox protein 4  
Size: 424 amino acids; 44940 Da
Subunit: May exist as a monomer or a dimer
Subcellular location: Nucleus. Note=Actively transported through the nuclear pore complex (NPC)
Miscellaneous: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome
found on the short arms of all acrocentric chromosomes as well as on several other chromosomes

Explore the universe of human proteins at neXtProt for DUX4: NX_Q9UBX2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBX2

    • DUX4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_149418.4  
    ENSEMBL proteins: 
     ENSP00000473851   ENSP00000451207   ENSP00000451304  

    Human Recombinant Protein Products for DUX4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DUX4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DUX4
    GenScript Custom Purified and Recombinant Proteins Services for DUX4
    Novus Biologicals DUX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUX4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DUX4 for ontologies           About GeneDecksing



    DUX4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DUX4 

    Assay Products for DUX4: 
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    Cloud-Clone Corp. ELISAs for DUX4 
    Cloud-Clone Corp. CLIAs for DUX4

    Protein Domains /
    Families
    for DUX4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    3 InterPro protein domains:
     IPR000047 HTH_motif
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UBX2

    ProtoNet protein and cluster: Q9UBX2

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
    Domain: Both homeobox domains confer nuclear targeting
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 2 homeobox DNA-binding domains


    DUX4 for domains           About GeneDecksing


    Function
    for DUX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUX4_HUMAN, Q9UBX2
    Function: Involved in transcriptional regulation

         Genatlas biochemistry entry for DUX4:
    double homeo box protein 4 in the partially deleted D4Z4 locus (FSHD)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    DUX4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DUX4:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUX4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUX4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUX4 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUX4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DUX4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DUX4
    Sirion Biotech Customized adenovirus for overexpression of DUX4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DUX4 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUX4 (NM_033178)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4
    Sirion Biotech Customized lentivirus for stable overexpression of DUX4 
                         Customized lentivirus expression plasmids for stable overexpression of DUX4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DUX4
    Search LifeMap BioReagents cell lines for DUX4
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUX4


    Pathways & Interactions
    for DUX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUX4

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    DUX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUX4

    Search CenterWatch for drugs/clinical trials and news about DUX4

    Transcripts
    for DUX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUX4 gene: 
    NM_033178.4  

    Unigene Cluster for DUX4:

    Double homeobox 4
    Hs.553518
    Unigene Representative Sequence: NM_033178
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000605758 ENST00000554285 ENST00000556625(uc010ist.1)
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUX4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DUX4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUX4
    Clone
    Products:             		 OriGene clones in human, mouse for DUX4 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUX4 (NM_033178)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX4
    Sirion Biotech Customized lentivirus for stable overexpression of DUX4 
                         Customized lentivirus expression plasmids for stable overexpression of DUX4 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for DUX4
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat DUX4
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4

    1 AceView cDNA sequence:

    NM_033178 

    GeneLoc Exon Structure


    Expression
    for DUX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DUX4 Expression
    About this image


    Genevestigator expression for DUX4

    SOURCE GeneReport for Unigene cluster: Hs.553518

    UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
    Tissue specificity: Does not seem to be expressed in normal muscle, but in muscle of individuals with FSHD, where
    it may be toxic to cells

        SABiosciences Custom PCR Arrays for DUX4
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for DUX4
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat DUX4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUX4

    Orthologs
    for DUX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of mammals.

    Orthologs for DUX4 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    dog
    (Canis familiaris)    		 Mammalia LOC1006837831 double homeobox protein 4-like protein 2-like 59.6(n)
    52.32(a)    		   100683783  XM_003435433.1  XP_003435481.1 


    ENSEMBL Gene Tree for DUX4 (if available)
    TreeFam Gene Tree for DUX4 (if available)

    Paralogs
    for DUX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUX4 gene
    DUX4L21 2  DUX4L51 2  DUX4L61 2  DUX4L31 2  DUX4L71 2  DUX4L41 2  DUX2  ENSG000002143252  
    DUXA2  
    18/23 SIMAP similar genes for DUX4 using alignment to 25 protein entries:     DUX4_HUMAN (see all proteins) (see all similar genes):
    DUX4L2    DUX4L3    DUX4L5    DUX4L6    DUX4L7    DUX4L4
    DUX4L9    DUX2    DUX5    DUX1    DUX3    HPX-2
    CIC/DUX4 fusion    LHX3    MSX1    PRRX1    PITX2    PAX6

    DUX4 for paralogs           About GeneDecksing



    Genomic Variants
    for DUX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for DUX4 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4n31CNV Duplication19718026
    nsv471357CNV Duplication19718026
    nsv471487CNV Duplication19718026
    nsv10641CNV Loss18304495
    nsv428243CNV Gain18775914
    nsv896428CNV Gain21882294
    nsv482152CNV Gain20164927
    esv23426CNV Gain+Loss19812545
    esv28562CNV Gain+Loss19812545
    nsv8752CNV Gain+Loss18304495


    Human Gene Mutation Database (HGMD): DUX4
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DUX4
    DNA2.0 Custom Variant and Variant Library Synthesis for DUX4

    Disorders / Diseases
    for DUX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606009    OMIM disorders: --

    UniProtKB/Swiss-Prot: DUX4_HUMAN, Q9UBX2
  • Facioscapulohumeral muscular dystrophy 1 (FSHD1) [MIM:158900]: A degenerative muscle disease
    characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The
    onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with
    impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the
    orbicularis oris and orbicularis oculi muscles. Note=The gene represented in this entry is involved in disease
    pathogenesis. The disease is caused by deletion of an integral number of units of a 3.3-kb tandem repeats, termed
    D4Z4 macrosatellite, located on chromosome 4q35. In unaffected subjects, the D4Z4 array consists of 11-150
    repeats, while in FSHD1 patients, the array is reduced to 1-10 repeats (PubMed:19320656). DUX4 is located in D4Z4
    macrosatellite which is epigenetically repressed in somatic tissues. D4Z4 chromatin relaxation in FSHD1 results
    in inefficient epigenetic repression of DUX4 and a variegated pattern of DUX4 protein expression in a subset of
    skeletal muscle nuclei. Ectopic expression of DUX4 in skeletal muscle activates the expression of stem cell and
    germline genes, and, when overexpressed in somatic cells, DUX4 can ultimately lead to cell death

    • 6 diseases for DUX4:    About MalaCards
    facioscapulohumeral muscular dystrophy    muscular dystrophy    cervical cancer    cervicitis
    hepatocellular carcinoma    sarcoma


    DUX4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DUX4
    Human Genome Epidemiology (HuGE) Navigator: DUX4 (1 document)

    Export disorders for DUX4 gene to outside databases

    Publications
    for DUX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUX4 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with DUX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Intracellular trafficking and dynamics of double homeodomain proteins. (PubMed id 15709750)1, 2, 9 Oestlund C.... Worman H.J. (2005)
    2. Polymorphism of the D4Z4 locus associated with facioscapulohumeral muscular dystrophy 1A in Shanghai population. (PubMed id 16086272)1, 4 Zhang Y.Z....Urtizberea J.A. (2005)
    3. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. (PubMed id 10433963)1, 2 Gabrieels J.... Belayew A. (1999)
    4. DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. (PubMed id 17984056)1, 9 Dixit M....Chen Y.W. (2007)
    5. Intrinsic epigenetic regulation of the D4Z4 macrosatel lite repeat in a transgenic mouse model for FSHD. (PubMed id 23593020)1 Krom Y.D....van der Maarel S.M. (2013)
    6. A focal domain of extreme demethylation within D4Z4 in FSHD2. (PubMed id 23284062)1 Hartweck L.M....Kyba M. (2013)
    7. Expression of the Human FSHD-Linked DUX4 Gene Induces Neurogenesis During Differentiation of Murine Embryonic Stem Cells. (PubMed id 23560660)1 Dandapat A....Kyba M. (2013)
    8. DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy? (PubMed id 23206257)1 Tassin A....Belayew A. (2013)
    9. Expression of DUX4 in zebrafish development recapitula tes facioscapulohumeral muscular dystrophy. (PubMed id 23108159)1 Mitsuhashi H....Kunkel L.M. (2013)
    10. Telomere position effect regulates DUX4 in human facio scapulohumeral muscular dystrophy. (PubMed id 23644600)1 Stadler G....Wright W.E. (2013)

    External Searches for DUX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DUX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22947 HGNC: 3082 AceView: DUX4 Ensembl:ENSG00000258389 euGenes: HUgn22947
    ECgene: DUX4 H-InvDB: DUX4

    Other Databases showing DUX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DUX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUX4 gene:
    Search GeneIP for patents involving DUX4

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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