DUX1 Gene
protein-coding GIFtS: 31
GCID: GC10U901220
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double homeobox 1(Previous names: double homeobox, 1 )
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Aliases
for DUX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Double Homeobox 11 2 | | Double Homeobox, 11 2 | | Double Homeobox Protein 12 |
Export aliases for DUX1 gene to outside databasesPrevious GC identifers: GC00U990584 GC04M191639 GC04M191318 GC10P135340 GC00M000309 |
Summaries
for DUX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for DUX1:
The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUXgene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 (PubMed 11245978)).See DUX4 (MIM 606009).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: DUX1_HUMAN, O43812Function: Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'
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Genomic Views
for DUX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DUX1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX1 |
Genomic Location:
Chromosome:10
GeneLoc information about chromosome 10 |
Proteins
for DUX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUX1_HUMAN, O43812 (See
protein sequence)Recommended Name: Double homeobox protein 1 Size: 170 amino acids; 19347 Da
Subcellular location: Nucleus. Note=Actively transported through the nuclear pore complex (NPC)
Miscellaneous: DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found onthe short arms of all acrocentric chromosomes as well as on several other chromosomesExplore the universe of human proteins at neXtProt for DUX1: NX_O43812
DUX1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_036278.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
DUX1 for ontologies About GeneDecksing
DUX1 Antibody Products:
Assay Products for DUX1: |
Protein
Domains /
Families
for DUX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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DUX1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43812ProtoNet protein and cluster: O43812 1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature
UniProtKB/Swiss-Prot: DUX1_HUMAN, O43812Domain: Homebox domain 2 confers nuclear targetingSimilarity: Belongs to the paired homeobox familySimilarity: Contains 2 homeobox DNA-binding domains |
Function
for DUX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: DUX1_HUMAN, O43812Function: Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUX1 (NM_012146) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- |
DUX1 for ontologies About GeneDecksing
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Pathways & Interactions
for DUX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUX1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 9736770 |
DUX1 for ontologies About GeneDecksing
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Drugs & Compounds
for DUX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUX1
Search CenterWatch for drugs/clinical trials and news about DUX1
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Transcripts
for DUX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for DUX1 gene: NM_012146.1 Unigene Cluster for DUX1: Double homeobox 1 Hs.274469 Unigene Representative Sequence: AJ001481
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DUX1 (NM_012146) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX1 |
Additional cDNA sequence: AJ001481.1 1 DOTS entry: DT.91751843
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Expression
for DUX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGATTTTGC
About this image
Genevestigator expression for DUX1
SOURCE GeneReport for Unigene cluster: Hs.274469
UniProtKB/Swiss-Prot: DUX1_HUMAN, O43812Tissue specificity: Expressed in rhabdomyosarcoma TE671 cells as well as in several other normal and cancer cells
SABiosciences Custom PCR Arrays for DUX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DUX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX1 |
Orthologs
for DUX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for DUX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for DUX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DUX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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DUX1 for disorders About GeneDecksing
OMIM gene information: 611441
OMIM disorders: --
1  disease for DUX1: About MalaCardsrhabdomyosarcoma
Export disorders for DUX1 gene to outside databases
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Publications
for DUX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for DUX1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3-kb dispersed repeated elements. (PubMed id 9736770)1, 2, 3 Ding H....Belayew A. (1998)
- Intracellular trafficking and dynamics of double homeodomain proteins. (PubMed id 15709750)1, 2, 9 Oestlund C.... Worman H.J. (2005)
- Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PubMed id 11245978)1, 3 Beckers M.-C.... Belayew A. (2001)
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External Searches for DUX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DUX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing DUX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUX1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DUX1 gene:
Search GeneIP for patents involving DUX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DUX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DUX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUX1 | | | OriGene Protein Over-expression Lysate for DUX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DUX1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DUX1 | | OriGene Custom Protein Services for DUX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUX1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUX1 |
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| | | | Search Tocris compounds for DUX1 |
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 | | | DUX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for DUX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUX1 |
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