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Aliases for DUX1 Gene

Aliases for DUX1 Gene

  • Double Homeobox 1 2 3
  • Double Homeobox, 1 2

External Ids for DUX1 Gene

Previous GeneCards Identifiers for DUX1 Gene

  • GC00U990584
  • GC04M191639
  • GC04M191318
  • GC10P135340
  • GC00M000309

Summaries for DUX1 Gene

Entrez Gene Summary for DUX1 Gene

  • The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]

GeneCards Summary for DUX1 Gene

DUX1 (Double Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding.

UniProtKB/Swiss-Prot for DUX1 Gene

  • Probable transcription activator. Binds the P5 DNA element sequence 5-GATCTGAGTCTAATTGAGAATTACTGTAC-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUX1 Gene

Genomics for DUX1 Gene

Genomic Location for DUX1 Gene

Orientation:
Unknown strand

Genomic View for DUX1 Gene

Cytogenetic band:

No data available for Regulatory Elements and RefSeq DNA sequence for DUX1 Gene

Proteins for DUX1 Gene

  • Protein details for DUX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43812-DUX1_HUMAN
    Recommended name:
    Double homeobox protein 1
    Protein Accession:
    O43812
    Secondary Accessions:

    Protein attributes for DUX1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19347 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes

neXtProt entry for DUX1 Gene

Proteomics data for DUX1 Gene at MOPED

Post-translational modifications for DUX1 Gene

No Post-translational modifications

Other Protein References for DUX1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for DUX1 Gene

Domains for DUX1 Gene

Suggested Antigen Peptide Sequences for DUX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43812

UniProtKB/Swiss-Prot:

DUX1_HUMAN :
  • O43812
Domain:
  • Homeobox domain 2 confers nuclear targeting
  • Contains 2 homeobox DNA-binding domains.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with DUX1: view

No data available for Gene Families for DUX1 Gene

Function for DUX1 Gene

Molecular function for DUX1 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription activator. Binds the P5 DNA element sequence 5-GATCTGAGTCTAATTGAGAATTACTGTAC-3.

Gene Ontology (GO) - Molecular Function for DUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DUX1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUX1 Gene

Localization for DUX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUX1 Gene

Nucleus. Note=Actively transported through the nuclear pore complex (NPC).

Gene Ontology (GO) - Cellular Components for DUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DUX1: view

No data available for Subcellular locations from COMPARTMENTS for DUX1 Gene

Pathways for DUX1 Gene

SuperPathways for DUX1 Gene

No Data Available

Interacting Proteins for DUX1 Gene

Gene Ontology (GO) - Biological Process for DUX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9736770
genes like me logo Genes that share ontologies with DUX1: view

No data available for Pathways by source for DUX1 Gene

Transcripts for DUX1 Gene

mRNA/cDNA for DUX1 Gene

(1) REFSEQ mRNAs :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUX1 Gene

No ASD Table

Relevant External Links for DUX1 Gene

ECgene alternative splicing isoforms for
DUX1

Expression for DUX1 Gene

mRNA expression in normal human tissues for DUX1 Gene

SOURCE GeneReport for Unigene cluster for DUX1 Gene Hs.274469

mRNA Expression by UniProt/SwissProt for DUX1 Gene

O43812-DUX1_HUMAN
Tissue specificity: Expressed in rhabdomyosarcoma TE671 cells as well as in several other normal and cancer cells.
genes like me logo Genes that share expressions with DUX1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for DUX1 Gene

Orthologs for DUX1 Gene

No data available for Orthologs and Evolution for DUX1 Gene

Paralogs for DUX1 Gene

Selected SIMAP similar genes for DUX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUX1: view

No data available for Paralogs for DUX1 Gene

Variants for DUX1 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DUX1 Gene

Disorders for DUX1 Gene

No disorders were found for DUX1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DUX1 Gene

Publications for DUX1 Gene

  1. Intracellular trafficking and dynamics of double homeodomain proteins. (PMID: 15709750) Oestlund C. … Worman H.J. (Biochemistry 2005) 3 4 23
  2. Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3-kb dispersed repeated elements. (PMID: 9736770) Ding H. … Belayew A. (Hum. Mol. Genet. 1998) 2 3 4
  3. Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. (PMID: 11245978) Beckers M.-C. … Belayew A. (Gene 2001) 2 3

Products for DUX1 Gene

Sources for DUX1 Gene

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