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Aliases for DUT Gene

Aliases for DUT Gene

  • Deoxyuridine Triphosphatase 2 3
  • DUTP Pyrophosphatase 2 3 4
  • DUTP Diphosphatase 2 3
  • EC 3.6.1.23 4 64
  • DUTPase 3 4
  • Deoxyuridine 5-Triphosphate Nucleotidohydrolase, Mitochondrial 3
  • DUTP Nucleotidohydrolase 3

External Ids for DUT Gene

Summaries for DUT Gene

Entrez Gene Summary for DUT Gene

  • This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUT Gene

DUT (Deoxyuridine Triphosphatase) is a Protein Coding gene. Diseases associated with DUT include cysticercosis. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for DUT Gene

  • This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Gene Wiki entry for DUT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUT Gene

Genomics for DUT Gene

Genomic Location for DUT Gene

Start:
48,331,011 bp from pter
End:
48,343,373 bp from pter
Size:
12,363 bases
Orientation:
Plus strand

Genomic View for DUT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUT Gene

Regulatory Elements for DUT Gene

Proteins for DUT Gene

  • Protein details for DUT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33316-DUT_HUMAN
    Recommended name:
    Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial
    Protein Accession:
    P33316
    Secondary Accessions:
    • A8K650
    • B4DPR5
    • O14785
    • Q16708
    • Q16860
    • Q6FHN1
    • Q6NSA3
    • Q96Q81

    Protein attributes for DUT Gene

    Size:
    252 amino acids
    Molecular mass:
    26563 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions
    SequenceCaution:
    • Sequence=AAB71393.1; Type=Frameshift; Positions=29, 47; Evidence={ECO:0000305}; Sequence=AAB93866.1; Type=Frameshift; Positions=29, 47; Evidence={ECO:0000305}; Sequence=AAB94642.1; Type=Frameshift; Positions=29, 47; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUT Gene

    Alternative splice isoforms for DUT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUT Gene

Proteomics data for DUT Gene at MOPED

Selected DME Specific Peptides for DUT Gene

Post-translational modifications for DUT Gene

  • Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys63, Lys91, and Lys163

Domains for DUT Gene

Protein Domains for DUT Gene

UniProtKB/Swiss-Prot:

DUT_HUMAN
Family:
  • Belongs to the dUTPase family.:
    • P33316
genes like me logo Genes that share domains with DUT: view

No data available for Gene Families for DUT Gene

Function for DUT Gene

Molecular function for DUT Gene

GENATLAS Biochemistry: dUTP pyrophosphatase,involved in DNA replication
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.5 uM for dUTP {ECO:0000269 PubMed:8631816}; Note=for both isoform 2 and isoform 3.;
UniProtKB/Swiss-Prot CatalyticActivity: dUTP + H(2)O = dUMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation is necessary for activity
UniProtKB/Swiss-Prot Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Enzyme Numbers (IUBMB) for DUT Gene

Gene Ontology (GO) - Molecular Function for DUT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IBA --
GO:0004170 dUTP diphosphatase activity EXP --
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DUT: view

Phenotypes for DUT Gene

GenomeRNAi human phenotypes for DUT:
genes like me logo Genes that share phenotypes with DUT: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUT Gene

Localization for DUT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUT Gene

Isoform 2: Nucleus.
Isoform 3: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUT Gene COMPARTMENTS Subcellular localization image for DUT gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DUT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8631816
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DUT: view

Pathways for DUT Gene

genes like me logo Genes that share pathways with DUT: view

UniProtKB/Swiss-Prot P33316-DUT_HUMAN

  • Pathway: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2

Gene Ontology (GO) - Biological Process for DUT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 1325640
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006226 dUMP biosynthetic process IEA --
GO:0006260 DNA replication TAS 1325640
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with DUT: view

Compounds for DUT Gene

(6) HMDB Compounds for DUT Gene

Compound Synonyms Cas Number PubMed IDs
Deoxyuridine triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
1173-82-6
dUMP
  • 2'-Deoxy-5'-uridylate
964-26-1
Magnesium
  • Magnesium
7439-95-4
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(2) Drugbank Compounds for DUT Gene

(18) Novoseek inferred chemical compound relationships for DUT Gene

Compound -log(P) Hits PubMed IDs
dutp 91.6 70
deoxyuridine 85.7 20
dudp 83.8 5
dttp 80.7 2
2-deoxyuridine-5-monophosphate 78.9 2
genes like me logo Genes that share compounds with DUT: view

Transcripts for DUT Gene

Unigene Clusters for DUT Gene

Deoxyuridine triphosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUT Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: - -

Relevant External Links for DUT Gene

GeneLoc Exon Structure for
DUT
ECgene alternative splicing isoforms for
DUT

Expression for DUT Gene

mRNA expression in normal human tissues for DUT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUT Gene

SOURCE GeneReport for Unigene cluster for DUT Gene Hs.527980

mRNA Expression by UniProt/SwissProt for DUT Gene

P33316-DUT_HUMAN
Tissue specificity: Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).
genes like me logo Genes that share expressions with DUT: view

Orthologs for DUT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUT 36
  • 98.94 (n)
  • 97.62 (a)
DUT 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 82 (a)
OneToMany
DUT 36
  • 89.41 (n)
  • 90.54 (a)
DUT 37
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DUT 36
  • 84.66 (n)
  • 85.45 (a)
DUT 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dut 36
  • 81.53 (n)
  • 87.26 (a)
Dut 16
Dut 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUT 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dut 36
  • 80.86 (n)
  • 88.39 (a)
chicken
(Gallus gallus)
Aves DUT 36
  • 75.97 (n)
  • 87.01 (a)
DUT 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUT 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7472 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733437 36
  • 66.28 (n)
  • 73.84 (a)
Str.1294 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2007 36
zebrafish
(Danio rerio)
Actinopterygii dut 36
  • 65.4 (n)
  • 73.42 (a)
dut 37
  • 64 (a)
OneToOne
wufa28d11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010159 36
  • 65.95 (n)
  • 73.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta dUTPase 36
  • 58.96 (n)
  • 65.31 (a)
dUTPase 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dut-1 36
  • 57.17 (n)
  • 60.61 (a)
dut-1 37
  • 21 (a)
OneToOne
K07A1.2 38
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR249C 36
  • 54.5 (n)
  • 53.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUT1 37
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2142 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 67 (a)
OneToMany
CSA.6436 37
  • 62 (a)
OneToMany
Species with no ortholog for DUT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUT Gene

ENSEMBL:
Gene Tree for DUT (if available)
TreeFam:
Gene Tree for DUT (if available)

Paralogs for DUT Gene

genes like me logo Genes that share paralogs with DUT: view

No data available for Paralogs for DUT Gene

Variants for DUT Gene

Sequence variations from dbSNP and Humsavar for DUT Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1224420 -- 48,336,829(-) CCATA(A/G)AGCAG intron-variant
rs1237834 -- 48,340,048(-) AGCTG(A/G)GAAAA intron-variant
rs1237835 -- 48,336,863(-) TCTAA(A/G)CCAGT intron-variant
rs1802838 -- 48,342,044(+) AAGGG(G/T)TTCAG reference, missense
rs2071296 -- 48,332,212(+) CTCCT(C/G)TTCCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DUT Gene

Variant ID Type Subtype PubMed ID
dgv746e1 CNV Complex 17122850

Relevant External Links for DUT Gene

HapMap Linkage Disequilibrium report
DUT

Disorders for DUT Gene

(1) MalaCards Diseases for DUT Gene

Search for DUT Gene in MalaCards »

(11) Novoseek inferred disease relationships for DUT Gene

Disease -log(P) Hits PubMed IDs
visna 56.2 1
ebv infections 38.4 1
herpes simplex 35.2 4
colorectal tumors 24.7 1
neoplastic disease 18.6 1

Relevant External Links for DUT

Genetic Association Database (GAD)
DUT
Human Genome Epidemiology (HuGE) Navigator
DUT
genes like me logo Genes that share disorders with DUT: view

No data available for UniProtKB/Swiss-Prot for DUT Gene

Publications for DUT Gene

  1. Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme. (PMID: 1325640) McIntosh E.M. … Haynes R.H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization. (PMID: 9070952) Cohen D. … Pearlman R.E. (Genomics 1997) 2 3 4 23
  3. Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. (PMID: 8631816) Ladner R.D. … Caradonna S.J. (J. Biol. Chem. 1996) 3 4 23
  4. Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase. (PMID: 8631817) Ladner R.D. … Caradonna S.J. (J. Biol. Chem. 1996) 3 4 23
  5. The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species. (PMID: 9228092) Ladner R.D. … Caradonna S.J. (J. Biol. Chem. 1997) 3 4 23

Products for DUT Gene

Sources for DUT Gene

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