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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DUT Gene

protein-coding GIFtS: 66
GCID: GC15P048623

Deoxyuridine Triphosphatase

(Previous name: dUTP pyrophosphatase)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Deoxyuridine Triphosphatase¹ ²
DUTP Pyrophosphatase¹ ² ³
dUTPase² ³
EC 3.6.1.23³ ⁸
Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Mitochondrial²
DUTP Nucleotidohydrolase²

External Ids:	HGNC: 3078¹	Entrez Gene: 1854²	Ensembl: ENSG00000128951⁷	OMIM: 601266⁵	UniProtKB: P33316³

Export aliases for DUT gene to outside databases

Previous GC identifers: GC15P044181 GC15P041669 GC15P046202 GC15P046339 GC15P046410 GC15P025461

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUT Gene:

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous,

homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes:

providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting

intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which

induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal

and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative

splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related

pseudogene is located on chromosome 19. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUT Gene:

DUT (deoxyuridine triphosphatase) is a protein-coding gene. Diseases associated with DUT include contagious pustular dermatitis, and laryngotracheitis, and among its related super-pathways are Metabolic pathways and pyrimidine deoxyribonucleotides biosynthesis from CTP. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: DUT_HUMAN, P33316

Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine

nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into

DNA

Gene Wiki entry for DUT Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NT_010194.17 NC_018926.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DUT gene promoter:
AML1a p53 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DUT promoter sequence

Search SABiosciences Chromatin IP Primers for DUT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.1 HGNC cytogenetic band: 15q21.1

DUT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUT gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P048623: view genomic region (about GC identifiers)

Start:	48,623,208 bp from pter	End:	48,635,570 bp from pter
Size:	12,363 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUT_HUMAN, P33316 (See protein sequence)

Recommended Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor

Size: 252 amino acids; 26563 Da

Cofactor: Magnesium

Subunit: Homotrimer

Subcellular location: Isoform 2: Nucleus

Subcellular location: Isoform 3: Mitochondrion

Miscellaneous: Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each

substrate molecule, residues from adjacent subunits contribute to the binding interactions

Sequence caution: Sequence=AAB71393.1; Type=Frameshift; Positions=29, 47; Sequence=AAB93866.1; Type=Frameshift;

Positions=29, 47; Sequence=AAB94642.1; Type=Frameshift; Positions=29, 47;

6 PDB 3D structures from and Proteopedia for DUT:

1Q5H (3D)

1Q5U (3D)

2HQU (3D)

3ARA (3D)

3ARN (3D)

3EHW (3D)

Secondary accessions: A8K650 B4DPR5 O14785 Q16708 Q16860 Q6FHN1 Q6NSA3 Q96Q81

Alternative splicing: 2 isoforms: P33316-3 P33316-2 (Major isoform. Phosphorylated in Ser-11. Contains a phosphoserine at position 11)

Explore the universe of human proteins at neXtProt for DUT: NX_P33316

Explore proteomics data for DUT at MOPED

Post-translational modifications:

UniProtKB: Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2.

Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated

UniProtKB: The initiator methionine is cleaved in isoform 2

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P33316

4 DME Specific Peptides for DUT (P33316)

GGFGSTG

GVIDEDYRGN

YGRVAPRSGLA

AAGYDLYSAYDYTIP

DUT Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001020419.1 NP_001020420.1 NP_001939.1

ENSEMBL proteins:

ENSP00000453667 ENSP00000454183 ENSP00000453717 ENSP00000370376 ENSP00000452749

ENSP00000452814 ENSP00000405160 ENSP00000454041 ENSP00000453683

Reactome Protein details: P33316
Human Recombinant Protein Products for DUT:

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	8631816
GO:0005654	nucleoplasm	TAS	--
GO:0005739	mitochondrion	IEA	--

DUT for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR008180 dUTP_pyroPase

IPR008181 dUTP_pyroPase_sf

Graphical View of Domain Structure for InterPro Entry P33316

ProtoNet protein and cluster: P33316

2 Blocks protein domains:

IPB003232 dCTP Deaminase

IPB008180 DeoxyUTP pyrophosphatase

UniProtKB/Swiss-Prot: DUT_HUMAN, P33316

Similarity: Belongs to the dUTPase family

DUT for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DUT_HUMAN, P33316

Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine

nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into

DNA

Catalytic activity: dUTP + H(2)O = dUMP + diphosphate

Enzyme regulation: Phosphorylation is necessary for activity

Biophysicochemical properties: Kinetic parameters: KM=2.5 uM for dUTP; Note=for both isoform 2 and isoform 3;

Genatlas biochemistry entry for DUT:

dUTP pyrophosphatase,involved in DNA replication

Enzyme Number (IUBMB): EC 3.6.1.23¹ ²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004170	dUTP diphosphatase activity	EXP	--
GO:0005515	protein binding	IPI	16189514
GO:0016787	hydrolase activity	--	--

DUT for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for DUT:

Decreased viability

Increased cell transformation

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for DUT

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DUT
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for DUT About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Metabolism

Metabolism

0.40

Metabolic pathways

0.40

superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)

	pyrimidine deoxyribonucleotides de novo biosynthesis I	0.88			pyrimidine deoxyribonucleotides de novo biosynthesis II	0.73
	superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)	0.88			superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis	0.71

Pyrimidine metabolism

Pyrimidine metabolism

0.50

Purine metabolism

Metabolism of nucleotides

0.42

Purine metabolism

Pyrimidine metabolism

0.38

Pathways by source See SuperPaths
Show all pathways

4 BioSystems Pathways for DUT

	superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
	pyrimidine deoxyribonucleotides de novo biosynthesis I
	pyrimidine deoxyribonucleotides de novo biosynthesis II

4 Reactome Pathways for DUT

	Metabolism of nucleotides
	Metabolism
	Pyrimidine metabolism
	Pyrimidine biosynthesis

2 Kegg Pathways (Kegg details for DUT):

	Pyrimidine metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: DUT_HUMAN, P33316

Pathway: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2

DUT for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DUT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for DUT (P33316^{1, 2, 3} ENSP00000370376⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NUDT18	Q6ZVK8¹^,²^,³, ENSP00000307852⁴	EBI-353224,EBI-740486 MINT-68046 I2D: score=4 STRING: ENSP00000307852
SPATA2	Q9UM82²^,³, ENSP00000289431⁴	MINT-66521 I2D: score=4 STRING: ENSP00000289431
RHOB	P62745³, ENSP00000272233⁴	I2D: score=2 STRING: ENSP00000272233
GH1	P01241³, ENSP00000312673⁴	I2D: score=1 STRING: ENSP00000312673
PPARA	Q07869³, ENSP00000262735⁴	I2D: score=1 STRING: ENSP00000262735

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	TAS	1325640
GO:0006206	pyrimidine nucleobase metabolic process	TAS	--
GO:0006226	dUMP biosynthetic process	IEA	--
GO:0006260	DNA replication	TAS	1325640
GO:0044281	small molecule metabolic process	TAS	--

DUT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DUT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUT

6 HMDB Compounds for DUT About this table

Compound	Synonyms	CAS #	PubMed Ids
Deoxyuridine triphosphate	2'-Deoxyuridine-5'-triphosphorate (see all 9)	1173-82-6	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--
dUMP	2'-Deoxy-5'-uridylate (see all 12)	964-26-1	--

2 DrugBank Compounds for DUT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Deoxyuridine-5'-Diphosphate	--	--	target	--	17139284 17016423
1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE	--	--	target	--	10592235

10/18 Novoseek inferred chemical compound relationships for DUT gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dutp	91.6	149	8923782 (3), 15322254 (3), 8805593 (3), 10329142 (3) (see all 45)
deoxyuridine	85.7	30	19052026 (2), 8595399 (2), 8013732 (2), 8221659 (2) (see all 15)
dudp	83.8	7	17932923 (3), 11420444 (1), 8798636 (1)
dttp	80.7	3	12369927 (1), 10329142 (1)
2'-deoxyuridine-5-monophosphate	78.9	3	2153555 (1), 10329142 (1)
zd9331	78	6	10952785 (3), 11487279 (1)
thymidylate	75.1	22	15322254 (3), 10952785 (2), 10698291 (2), 18519027 (2) (see all 9)
pyrophosphate	64.5	14	12369927 (1), 17452782 (1), 8805593 (1), 2153555 (1) (see all 9)
fudr	61.8	14	7652165 (2), 8162567 (2), 15322254 (1), 8221659 (1) (see all 5)
cytosine	48.7	1	1694967 (1)

Search CenterWatch for drugs/clinical trials and news about DUT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUT gene (3 alternative transcripts):

NM_001025248.1 NM_001025249.1 NM_001948.3

Unigene Cluster for DUT:

Deoxyuridine triphosphatase

Hs.527980 [show with all ESTs]

Unigene Representative Sequence: NM_001025248

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000559935 ENST00000559416 ENST00000558813 ENST00000331200(uc001zws.3 uc001zwt.3)

ENST00000558472 ENST00000558978 ENST00000455976(uc001zww.3) ENST00000559540

ENST00000558367 ENST00000561350 ENST00000559852

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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Additional mRNA sequence:

AB049113.2 AK000629.1 AK291515.1 AK298464.1 AK312122.1 BC033645.1 BC070339.1 BC110377.1

CR541720.1 CR541781.1 L11877.1 M89913.1 U31930.1 U62891.1 U90223.1

15 DOTS entries:

DT.452923 DT.95377446 DT.100823718 DT.100823711 DT.91774168 DT.91774170 DT.100823709 DT.100823721

DT.218148 DT.91774169 DT.97764571 DT.95377854 DT.100035287 DT.100823717 DT.121072702

24/417 AceView cDNA sequences (see all 417):

AA335423 AA380259 BM693072 AA830251 CD677395 BM559498 BU608498 BG697899

AI634515 BG654389 CR607847 AA284034 BM757904 BU729937 AB049113 BM763640

AW007239 R28378 AI693247 BM840182 AI362673 BQ778048 NM_001948 BU677665

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DUT (see all 9) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	·	2g	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:					-		-		-		-		-		-		-		-				-										-
SP2:															-		-		-				-										-
SP3:																			-				-										-
SP4:																			-				-
SP5:					-		-		-		-		-		-		-		-				-

ECgene alternative splicing isoforms for DUT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUT expression in normal human tissues (normalized intensities) DUT embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGCTCCGCT

About this image

DUT expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/6 selected tissues (see all 6) fully expand


Blood (Hematopoietic System) fully expand to see all 4 entries
bone marrow cd34+

Umbilical Cord (Extraembryonic Tissues)
stem cells (umbilical cord cd34+)

Inner Cell Mass (Early Embryonic Tissues)
CyT49

Skeletal Muscle (Muscoskeletal System)
tongue squamous cells

Lymph (Hematopoietic System)
lymph node

See DUT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUT

SOURCE GeneReport for Unigene cluster: Hs.527980

UniProtKB/Swiss-Prot: DUT_HUMAN, P33316

Tissue specificity: Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2

expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with

the cessation of nuclear DNA replication (at protein level)

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DUT gene from 10/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dut^{1 , 5}	deoxyuridine triphosphatase^{1, 5}	76.84(n)¹ 81.05(a)¹		2 (61.33 cM)⁵ 110074¹ NM_001159646.1¹ NP_001153118.1¹ 125247190⁵
chicken (Gallus gallus)	Aves	DUT¹	deoxyuridine triphosphatase	75.97(n) 87.01(a)		769338 NM_001079488.1 NP_001072956.1
lizard (Anolis carolinensis)	Reptilia	DUT⁶	Uncharacterized protein	67(a)	1 ↔ 1	GL343806.1(24610-36072)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7472²	Xenopus laevis transcribed sequence with moderate similarity more	74.45(n)		48047642
zebrafish (Danio rerio)	Actinopterygii	wufa28d11²	Transcribed sequence with moderate similarity to protein more	73.7(n)		CK354832.1
fruit fly (Drosophila melanogaster)	Insecta	dUTPase¹	Deoxyuridine triphosphatase	58.96(n) 65.31(a)		34529 NM_135635.2 NP_609479.1
worm (Caenorhabditis elegans)	Secernentea	K07A1.2³ dut-1¹	deoxyuridine 5'-triphosphate nucleotidohydrolase³ Protein DUT-1¹	58(a)³ 57.17(n)¹ 60.61(a)¹		I(9593478-9595191)³ 172794¹ NM_001026382.3¹ NP_001021553.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DUT1¹	Dut1p	56.93(n) 55.47(a)		852554 NP_009811.3
thale cress (Arabidopsis thaliana)	eudicotyledons	DUT1¹	dUTP pyrophosphatase	63.41(n) 63.91(a)		823847 NM_114561.3 NP_190278.1
rice (Oryza sativa)	Liliopsida	Os03g0669100¹	hypothetical protein	54.63(n) 58.33(a)		4333679 NM_001057397.1 NP_001050862.1

ENSEMBL Gene Tree for DUT (if available)
TreeFam Gene Tree for DUT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DUT gene

DUT for paralogs About GeneDecksing

5/9 Pseudogenes.org Pseudogenes for DUT (see all 9)
PGOHUM00000262119 PGOHUM00000245069 PGOHUM00000238159 PGOHUM00000262001 PGOHUM00000246007

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181282904^1,2		--	25454653(+)	`TAAAAC/TGAGAG`	2	--	us2k¹		0	--	--	--	--
rs200629984^1,2		--	25455646(+)	`ATCTT-/TAAGTAC`	3	--	us2k¹		0	--	--	--	--
rs201166131^1,2		--	25455648(+)	`CTTAG-/TACTACAA`	3	--	cds¹		0	--	--	--	--
rs28381089^1,2	F	--	25455652(+)	`AGTAC-/TACAAGCA`	3	--	cds¹		5		NS	188
rs28381102^1,2	F	--	25457103(+)	`GGGGGG/CGTGGG`	3	--	int¹ us2k¹		5		NS	186
rs184273452^1,2		--	28687828(+)	`AGAAGA/GTTCAA`	2	--	us2k¹		0	--	--	--	--
rs3759912^1,2	C	--	28687972(+)	`tgggcA/Ggatca`	2	--	us2k¹		4		NA WA	8
rs190290692^1,2	C	--	28688111(+)	`AATTGC/TTTGAA`	2	--	us2k¹		0	--	--	--	--
rs8039967^1,2	A	--	28688189(+)	`aaaaaA/Caaaaa`	2	--	us2k¹		0	--	--	--	--
rs8039971^1,2	A	--	28688195(+)	`aaaaaA/CTATGA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DUT (48623208 - 48635570 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for DUT: About this table

Variant ID	Type	Subtype	PubMed ID
dgv746e1	CNV	Complex	17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601266 OMIM disorders: --

20/24 diseases for DUT (see all 24): About MalaCards

contagious pustular dermatitis laryngotracheitis cysticercosis chronic fatigue syndrome

autoimmune hepatitis herpes simplex stomach cancer vaccinia

kaposi's sarcoma dermatitis psoriasis cervical cancer

sarcoma tuberculosis cervicitis colorectal cancer

pneumonia lung cancer colon cancer hepatocellular carcinoma

DUT for disorders About GeneDecksing

10/11 Novoseek inferred disease relationships for DUT gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
visna	56.2	1	9847382 (1)
ebv infections	38.4	4	19124728 (1)
herpes simplex	35.2	6	2168898 (1), 8391186 (1), 9400986 (1), 10774198 (1)
colorectal tumors	24.7	1	8162567 (1)
neoplastic disease	18.6	1	12376965 (1)
colon cancer	2.21	4	10910061 (2), 12374095 (1)
breast cancer	0	1	18790783 (1)
hiv infections	0	2	10329142 (1), 10752557 (1)
tumors	0	9	10910061 (2), 17955371 (1), 18837522 (1), 16325515 (1) (see all 5)
cancer	0	12	15322254 (2), 17880943 (1), 20084279 (1), 9360704 (1) (see all 10)

Genetic Association Database (GAD): DUT
Human Genome Epidemiology (HuGE) Navigator: DUT (3 documents)

Export disorders for DUT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DUT gene, integrated from 9 sources (see all 148):
(articles sorted by number of sources associating them with DUT)

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world of online information

Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme. (PubMed id 1325640)^{1, 2, 3, 9} McIntosh E.M.... Haynes R.H. (1992)
Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization. (PubMed id 9070952)^{1, 2, 3, 9} Cohen D....Pearlman R.E. (1997)
Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase. (PubMed id 8631817)^{1, 2, 9} Ladner R.D....Caradonna S.J. (1996)
Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. (PubMed id 8805593)^{1, 2, 9} Mol C.D.... Tainer J.A. (1996)
Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. (PubMed id 8631816)^{1, 2, 9} Ladner R.D.... Caradonna S.J. (1996)
Maturation stage and proliferation-dependent expression of dUTPase in human T cells. (PubMed id 8389461)^{1, 2, 9} Strahler J.R.... Hanash S.M. (1993)
The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species. (PubMed id 9228092)^{1, 2, 9} Ladner R.D. and Caradonna S.J. (1997)
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. (PubMed id 17880943)^{1, 2, 9} Varga B....Vertessy B.G. (2007)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (2010)
Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. (PubMed id 19403629)^{1, 4} Chanson A....Mason J.B. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1854	HGNC: 3078	AceView: DUT	Ensembl:ENSG00000128951	euGenes: HUgn1854
ECgene: DUT	Kegg: 1854	H-InvDB: DUT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DUT	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/dut/

Intellectual Property for DUT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DUT gene:
Search GeneIP for patents involving DUT

GeneCards and IP:
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