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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUT Gene

protein-coding   GIFtS: 66
GCID: GC15P048623

Deoxyuridine Triphosphatase

(Previous name: dUTP pyrophosphatase)
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Aliases
for DUT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Deoxyuridine Triphosphatase1 2
DUTP Pyrophosphatase1 2 3
dUTPase2 3
EC 3.6.1.233 8
Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Mitochondrial2
DUTP Nucleotidohydrolase2

External Ids:    HGNC: 30781   Entrez Gene: 18542   Ensembl: ENSG000001289517   OMIM: 6012665   UniProtKB: P333163   

Export aliases for DUT gene to outside databases

Previous GC identifers: GC15P044181 GC15P041669 GC15P046202 GC15P046339 GC15P046410 GC15P025461


Summaries
for DUT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUT Gene:
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric
enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a
precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools
of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision
repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is
self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different
isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DUT Gene: 
DUT (deoxyuridine triphosphatase) is a protein-coding gene. Diseases associated with DUT include contagious pustular dermatitis, and laryngotracheitis, and among its related super-pathways are Metabolic pathways and pyrimidine deoxyribonucleotides biosynthesis from CTP. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: DUT_HUMAN, P33316
Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine
nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

Gene Wiki entry for DUT Gene


Genomic Views
for DUT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUT gene promoter:
         AML1a   p53   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DUT promoter sequence
   Search SABiosciences Chromatin IP Primers for DUT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1

DUT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUT gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P048623:  view genomic region     (about GC identifiers)

Start:
 48,623,208 bp from pter      End:
 48,635,570 bp from pter
Size:
 12,363 bases      Orientation:
 plus strand

Proteins
for DUT gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DUT_HUMAN, P33316 (See protein sequence)
Recommended Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor  
Size: 252 amino acids; 26563 Da
Cofactor: Magnesium
Subunit: Homotrimer
Subcellular location: Isoform 2: Nucleus
Subcellular location: Isoform 3: Mitochondrion
Miscellaneous: Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each
substrate molecule, residues from adjacent subunits contribute to the binding interactions
Sequence caution: Sequence=AAB71393.1; Type=Frameshift; Positions=29, 47; Sequence=AAB93866.1; Type=Frameshift;
Positions=29, 47; Sequence=AAB94642.1; Type=Frameshift; Positions=29, 47;
6 PDB 3D structures from and Proteopedia for DUT:
1Q5H (3D)        1Q5U (3D)        2HQU (3D)        3ARA (3D)        3ARN (3D)        3EHW (3D)    
Secondary accessions: A8K650 B4DPR5 O14785 Q16708 Q16860 Q6FHN1 Q6NSA3 Q96Q81
Alternative splicing: 2 isoforms:  P33316-3   P33316-2   (Major isoform. Phosphorylated in Ser-11. Contains a phosphoserine at position 11)

Explore the universe of human proteins at neXtProt for DUT: NX_P33316

Explore proteomics data for DUT at MOPED 

Post-translational modifications:

  • UniProtKB: Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2.
    • Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated
  • UniProtKB: The initiator methionine is cleaved in isoform 2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33316

    • 4 DME Specific Peptides for DUT (P33316)
     GGFGSTG  GVIDEDYRGN  YGRVAPRSGLA  AAGYDLYSAYDYTIP 

    DUT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUT Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001020419.1  NP_001020420.1  NP_001939.1  

    ENSEMBL proteins: 
     ENSP00000453667   ENSP00000454183   ENSP00000453717   ENSP00000370376   ENSP00000452749  
     ENSP00000452814   ENSP00000405160   ENSP00000454041   ENSP00000453683  
    Reactome Protein details: P33316
    Human Recombinant Protein Products for DUT: 
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    Novus Biologicals DUT Proteins
    Novus Biologicals DUT Lysates
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DUT
    Cloud-Clone Corp. Proteins for DUT 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8631816
    GO:0005654nucleoplasm TAS--
    GO:0005739mitochondrion IEA--

    DUT for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DUT gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR008180 dUTP_pyroPase
     IPR008181 dUTP_pyroPase_sf

    Graphical View of Domain Structure for InterPro Entry P33316

    ProtoNet protein and cluster: P33316

    2 Blocks protein domains:
    IPB003232 dCTP Deaminase
    IPB008180 DeoxyUTP pyrophosphatase


    UniProtKB/Swiss-Prot: DUT_HUMAN, P33316
    Similarity: Belongs to the dUTPase family


    DUT for domains           About GeneDecksing


    Function
    for DUT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUT_HUMAN, P33316
    Function: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine
    nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
    Catalytic activity: dUTP + H(2)O = dUMP + diphosphate
    Enzyme regulation: Phosphorylation is necessary for activity
    Biophysicochemical properties: Kinetic parameters: KM=2.5 uM for dUTP; Note=for both isoform 2 and isoform 3;

         Genatlas biochemistry entry for DUT:
    dUTP pyrophosphatase,involved in DNA replication

         Enzyme Number (IUBMB): EC 3.6.1.231 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004170dUTP diphosphatase activity EXP--
    GO:0005515protein binding IPI16189514
    GO:0016787hydrolase activity ----
         
    DUT for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUT:
     Decreased viability  Increased cell transformation 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUT

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUT
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate DUT:
    hsa-miR-374b* hsa-miR-203 hsa-miR-2115 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: DUT 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DUT
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DUT
                         Customized adenovirus for potent knockdown of DUT

    Clone
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    OriGene ORF clones in mouse, rat for DUT
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    GenScript: all cDNA clones in your preferred vector (see all 3): DUT (NM_001025248)
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUT


    Pathways & Interactions
    for DUT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DUT About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    		Metabolism0.40
    		Metabolic pathways0.40
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    		pyrimidine deoxyribonucleotides de novo biosynthesis I0.88
    		pyrimidine deoxyribonucleotides de novo biosynthesis II0.73
    		superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)0.88
    		superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.71
    3Pyrimidine metabolism
    		Pyrimidine metabolism0.50
    4Purine metabolism
    		Metabolism of nucleotides0.42
    5Purine metabolism
    		Pyrimidine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for DUT
        superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    pyrimidine deoxyribonucleotides de novo biosynthesis I
    pyrimidine deoxyribonucleotides de novo biosynthesis II

    4        Reactome Pathways for DUT
        Metabolism of nucleotides
    Metabolism
    Pyrimidine metabolism
    Pyrimidine biosynthesis


    2         Kegg Pathways  (Kegg details for DUT):
        Pyrimidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DUT_HUMAN, P33316
    Pathway: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2


    DUT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for DUT (P333161, 2, 3 ENSP000003703764) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT18Q6ZVK81, 2, 3, ENSP000003078524EBI-353224,EBI-740486 MINT-68046 I2D: score=4 STRING: ENSP00000307852
    SPATA2Q9UM822, 3, ENSP000002894314MINT-66521 I2D: score=4 STRING: ENSP00000289431
    RHOBP627453, ENSP000002722334I2D: score=2 STRING: ENSP00000272233
    GH1P012413, ENSP000003126734I2D: score=1 STRING: ENSP00000312673
    PPARAQ078693, ENSP000002627354I2D: score=1 STRING: ENSP00000262735
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS1325640
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006226dUMP biosynthetic process IEA--
    GO:0006260DNA replication TAS1325640
    GO:0044281small molecule metabolic process TAS--

    DUT for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUT

    6 HMDB Compounds for DUT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Deoxyuridine triphosphate2'-Deoxyuridine-5'-triphosphorate (see all 9)1173-82-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    2 DrugBank Compounds for DUT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Deoxyuridine-5'-Diphosphate-- --target--17139284 17016423
    1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE-- --target--10592235

    10/18 Novoseek inferred chemical compound relationships for DUT gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dutp 91.6 149 8923782 (3), 15322254 (3), 8805593 (3), 10329142 (3) (see all 45)
    deoxyuridine 85.7 30 19052026 (2), 8595399 (2), 8013732 (2), 8221659 (2) (see all 15)
    dudp 83.8 7 17932923 (3), 11420444 (1), 8798636 (1)
    dttp 80.7 3 12369927 (1), 10329142 (1)
    2'-deoxyuridine-5-monophosphate 78.9 3 2153555 (1), 10329142 (1)
    zd9331 78 6 10952785 (3), 11487279 (1)
    thymidylate 75.1 22 15322254 (3), 10952785 (2), 10698291 (2), 18519027 (2) (see all 9)
    pyrophosphate 64.5 14 12369927 (1), 17452782 (1), 8805593 (1), 2153555 (1) (see all 9)
    fudr 61.8 14 7652165 (2), 8162567 (2), 15322254 (1), 8221659 (1) (see all 5)
    cytosine 48.7 1 1694967 (1)

    Search CenterWatch for drugs/clinical trials and news about DUT

    Transcripts
    for DUT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUT gene (3 alternative transcripts): 
    NM_001025248.1  NM_001025249.1  NM_001948.3  

    Unigene Cluster for DUT:

    Deoxyuridine triphosphatase
    Hs.527980  [show with all ESTs]
    Unigene Representative Sequence: NM_001025248
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559935 ENST00000559416 ENST00000558813 ENST00000331200(uc001zws.3 uc001zwt.3)
    ENST00000558472 ENST00000558978 ENST00000455976(uc001zww.3) ENST00000559540
    ENST00000558367 ENST00000561350 ENST00000559852
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Clone
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    Additional mRNA sequence: 

    AB049113.2 AK000629.1 AK291515.1 AK298464.1 AK312122.1 BC033645.1 BC070339.1 BC110377.1 
    CR541720.1 CR541781.1 L11877.1 M89913.1 U31930.1 U62891.1 U90223.1 

    15 DOTS entries:

    DT.452923  DT.95377446  DT.100823718  DT.100823711  DT.91774168  DT.91774170  DT.100823709  DT.100823721 
    DT.218148  DT.91774169  DT.97764571  DT.95377854  DT.100035287  DT.100823717  DT.121072702 

    24/417 AceView cDNA sequences (see all 417):

    AA335423 AA380259 BM693072 AA830251 CD677395 BM559498 BU608498 BG697899 
    AI634515 BG654389 CR607847 AA284034 BM757904 BU729937 AB049113 BM763640 
    AW007239 R28378 AI693247 BM840182 AI362673 BQ778048 NM_001948 BU677665 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DUT (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:              -     -     -     -     -     -     -     -           -                             -                     
    SP2:                                            -     -     -           -                             -                     
    SP3:                                                        -           -                             -                     
    SP4:                                                        -           -                                                   
    SP5:              -     -     -     -     -     -     -     -           -                                                   


    ECgene alternative splicing isoforms for DUT

    Expression
    for DUT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUT expression in normal human tissues (normalized intensities)      DUT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCCGCT
    DUT Expression
    About this image


    DUT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             bone marrow cd34+
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)
     
     Inner Cell Mass (Early Embryo)
             CyT49
     
     Skeletal Muscle (Muscoskeletal System)
             tongue squamous cells
     
     Lymph (Cardiovascular System)
             lymph node

    See DUT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUT

    SOURCE GeneReport for Unigene cluster: Hs.527980

    UniProtKB/Swiss-Prot: DUT_HUMAN, P33316
    Tissue specificity: Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression
    correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of
    nuclear DNA replication (at protein level)

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    Orthologs
    for DUT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUT gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dut1 , 5 deoxyuridine triphosphatase1, 5 76.84(n)1
    81.05(a)1    		   2 (61.33 cM)5
    1100741  NM_001159646.11  NP_001153118.11 
     1252471905 
    chicken
    (Gallus gallus)    		 Aves DUT1 deoxyuridine triphosphatase 75.97(n)
    87.01(a)    		   769338  NM_001079488.1  NP_001072956.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DUT6
    		 Uncharacterized protein
    		 67(a)
    		 1 ↔ 1
    		 GL343806.1(24610-36072)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.74722 Xenopus laevis transcribed sequence with moderate similarity more 74.45(n)    48047642 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa28d112 Transcribed sequence with moderate similarity to protein more 73.7(n)    CK354832.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dUTPase1 Deoxyuridine triphosphatase 58.96(n)
    65.31(a)    		   34529  NM_135635.2  NP_609479.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea K07A1.23
    dut-11    		 deoxyuridine 5'-triphosphate
    nucleotidohydrolase3
    Protein DUT-11    		 58(a)3
    57.17(n)1
    60.61(a)1    		   I(9593478-9595191)3
    1727941  NM_001026382.31  NP_001021553.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DUT11 Dut1p 56.93(n)
    55.47(a)    		   852554   NP_009811.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DUT11 dUTP pyrophosphatase 63.41(n)
    63.91(a)    		   823847  NM_114561.3  NP_190278.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g06691001 hypothetical protein 54.63(n)
    58.33(a)    		   4333679  NM_001057397.1  NP_001050862.1 


    ENSEMBL Gene Tree for DUT (if available)
    TreeFam Gene Tree for DUT (if available)

    Paralogs
    for DUT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUT gene

    DUT for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for DUT (see all 9)
    PGOHUM00000262119 PGOHUM00000245069 PGOHUM00000238159 PGOHUM00000262001 PGOHUM00000246007


    Genomic Variants
    for DUT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/266 SNPs in DUT are shown (see all 266)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1812829041,2
    		--25454653(+) TAAAAC/TGAGAG 2 -- us2k10--------
    rs2006299841,2
    		--25455646(+) ATCTT-/TAAGTAC 3 -- us2k10--------
    rs2011661311,2
    		--25455648(+) CTTAG-/TACTACAA 3 -- cds10--------
    rs283810891,2
    		F--25455652(+) AGTAC-/TACAAGCA 3 -- cds15Minor allele frequency- TAC:0.02NS 188
    rs283811021,2
    		F--25457103(+) GGGGGG/CGTGGG 3 -- int1 us2k15Minor allele frequency- C:0.01NS 186
    rs1842734521,2
    		--28687828(+) AGAAGA/GTTCAA 2 -- us2k10--------
    rs37599121,2
    		C--28687972(+) tgggcA/Ggatca 2 -- us2k14Minor allele frequency- G:0.12NA WA 8
    rs1902906921,2
    		C--28688111(+) AATTGC/TTTGAA 2 -- us2k10--------
    rs80399671,2
    		A--28688189(+) aaaaaA/Caaaaa 2 -- us2k10--------
    rs80399711,2
    		A--28688195(+) aaaaaA/CTATGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUT (48623208 - 48635570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DUT:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv746e1CNV Complex17122850

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    Disorders / Diseases
    for DUT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUT for disorders           About GeneDecksing

    OMIM gene information: 601266    OMIM disorders: --

    20/24 diseases for DUT (see all 24):    About MalaCards
    contagious pustular dermatitis    laryngotracheitis    cysticercosis    chronic fatigue syndrome
    autoimmune hepatitis    herpes simplex    stomach cancer    vaccinia
    kaposi's sarcoma    dermatitis    psoriasis    cervical cancer
    sarcoma    tuberculosis    cervicitis    colorectal cancer
    pneumonia    lung cancer    colon cancer    hepatocellular carcinoma

    10/11 Novoseek inferred disease relationships for DUT gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    visna 56.2 1 9847382 (1)
    ebv infections 38.4 4 19124728 (1)
    herpes simplex 35.2 6 2168898 (1), 8391186 (1), 9400986 (1), 10774198 (1)
    colorectal tumors 24.7 1 8162567 (1)
    neoplastic disease 18.6 1 12376965 (1)
    colon cancer 2.21 4 10910061 (2), 12374095 (1)
    breast cancer 0 1 18790783 (1)
    hiv infections 0 2 10329142 (1), 10752557 (1)
    tumors 0 9 10910061 (2), 17955371 (1), 18837522 (1), 16325515 (1) (see all 5)
    cancer 0 12 15322254 (2), 17880943 (1), 20084279 (1), 9360704 (1) (see all 10)

    Genetic Association Database (GAD): DUT
    Human Genome Epidemiology (HuGE) Navigator: DUT (3 documents)

    Export disorders for DUT gene to outside databases

    Publications
    for DUT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUT gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with DUT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme. (PubMed id 1325640)1, 2, 3, 9 McIntosh E.M.... Haynes R.H. (1992)
    2. Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization. (PubMed id 9070952)1, 2, 3, 9 Cohen D....Pearlman R.E. (1997)
    3. Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase. (PubMed id 8631817)1, 2, 9 Ladner R.D....Caradonna S.J. (1996)
    4. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. (PubMed id 8805593)1, 2, 9 Mol C.D.... Tainer J.A. (1996)
    5. Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. (PubMed id 8631816)1, 2, 9 Ladner R.D.... Caradonna S.J. (1996)
    6. Maturation stage and proliferation-dependent expression of dUTPase in human T cells. (PubMed id 8389461)1, 2, 9 Strahler J.R.... Hanash S.M. (1993)
    7. The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species. (PubMed id 9228092)1, 2, 9 Ladner R.D. and Caradonna S.J. (1997)
    8. Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. (PubMed id 17880943)1, 2, 9 Varga B....Vertessy B.G. (2007)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    10. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. (PubMed id 19403629)1, 4 Chanson A....Mason J.B. (2009)

    External Searches for DUT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DUT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1854 HGNC: 3078 AceView: DUT Ensembl:ENSG00000128951 euGenes: HUgn1854
    ECgene: DUT Kegg: 1854 H-InvDB: DUT

    Other Databases showing DUT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUT Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dut/

    Intellectual Property
    for DUT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUT gene:
    Search GeneIP for patents involving DUT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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