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Aliases for DUT Gene

Aliases for DUT Gene

  • Deoxyuridine Triphosphatase 2 3 5
  • DUTP Pyrophosphatase 2 3 4
  • DUTP Diphosphatase 2 3
  • EC 3.6.1.23 4 63
  • DUTPase 3 4
  • DUTP Nucleotidohydrolase 3

External Ids for DUT Gene

Previous GeneCards Identifiers for DUT Gene

  • GC15P044181
  • GC15P041669
  • GC15P046202
  • GC15P046339
  • GC15P046410
  • GC15P048623
  • GC15P025461

Summaries for DUT Gene

Entrez Gene Summary for DUT Gene

  • This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUT Gene

DUT (Deoxyuridine Triphosphatase) is a Protein Coding gene. Diseases associated with DUT include cysticercosis. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include poly(A) RNA binding and magnesium ion binding.

UniProtKB/Swiss-Prot for DUT Gene

  • This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Gene Wiki entry for DUT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUT Gene

Genomics for DUT Gene

Regulatory Elements for DUT Gene

Promoters for DUT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUT on UCSC Golden Path with GeneCards custom track

Genomic Location for DUT Gene

Chromosome:
15
Start:
48,331,011 bp from pter
End:
48,343,373 bp from pter
Size:
12,363 bases
Orientation:
Plus strand

Genomic View for DUT Gene

Genes around DUT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUT Gene

Proteins for DUT Gene

  • Protein details for DUT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33316-DUT_HUMAN
    Recommended name:
    Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial
    Protein Accession:
    P33316
    Secondary Accessions:
    • A8K650
    • B4DPR5
    • O14785
    • Q16708
    • Q16860
    • Q6FHN1
    • Q6NSA3
    • Q96Q81

    Protein attributes for DUT Gene

    Size:
    252 amino acids
    Molecular mass:
    26563 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions.
    SequenceCaution:
    • Sequence=AAB71393.1; Type=Frameshift; Positions=29, 47; Evidence={ECO:0000305}; Sequence=AAB93866.1; Type=Frameshift; Positions=29, 47; Evidence={ECO:0000305}; Sequence=AAB94642.1; Type=Frameshift; Positions=29, 47; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUT Gene

    Alternative splice isoforms for DUT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUT Gene

Proteomics data for DUT Gene at MOPED

Selected DME Specific Peptides for DUT Gene

Post-translational modifications for DUT Gene

  • Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
  • Ubiquitination at Lys 63 and Lys 91
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for DUT Gene

Protein Domains for DUT Gene

Suggested Antigen Peptide Sequences for DUT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P33316

UniProtKB/Swiss-Prot:

DUT_HUMAN :
  • Belongs to the dUTPase family.
Family:
  • Belongs to the dUTPase family.
genes like me logo Genes that share domains with DUT: view

No data available for Gene Families for DUT Gene

Function for DUT Gene

Molecular function for DUT Gene

GENATLAS Biochemistry:
dUTP pyrophosphatase,involved in DNA replication
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.5 uM for dUTP {ECO:0000269 PubMed:8631816}; Note=for both isoform 2 and isoform 3.;
UniProtKB/Swiss-Prot CatalyticActivity:
dUTP + H(2)O = dUMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation is necessary for activity.
UniProtKB/Swiss-Prot Function:
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Enzyme Numbers (IUBMB) for DUT Gene

Gene Ontology (GO) - Molecular Function for DUT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004170 dUTP diphosphatase activity EXP,IEA 8631816
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUT: view
genes like me logo Genes that share phenotypes with DUT: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUT Gene

Localization for DUT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUT Gene

Isoform 2: Nucleus.
Isoform 3: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUT Gene COMPARTMENTS Subcellular localization image for DUT gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DUT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DUT: view

Pathways & Interactions for DUT Gene

genes like me logo Genes that share pathways with DUT: view

UniProtKB/Swiss-Prot P33316-DUT_HUMAN

  • Pathway: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Gene Ontology (GO) - Biological Process for DUT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 1325640
GO:0044281 small molecule metabolic process TAS --
GO:0046081 dUTP catabolic process IBA --
GO:0046134 pyrimidine nucleoside biosynthetic process TAS --
genes like me logo Genes that share ontologies with DUT: view

No data available for SIGNOR curated interactions for DUT Gene

Drugs & Compounds for DUT Gene

(8) Drugs for DUT Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE Experimental Pharma Target 0
Deoxyuridine-5'-Diphosphate Experimental Pharma Target 0
dUMP Experimental Pharma 0
Magnesium Nutra 0

(16) Additional Compounds for DUT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphoric acid = dUTP
  • Deoxy-UTP
1173-82-6
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUT: view

Transcripts for DUT Gene

Unigene Clusters for DUT Gene

Deoxyuridine triphosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUT Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: - -

Relevant External Links for DUT Gene

GeneLoc Exon Structure for
DUT
ECgene alternative splicing isoforms for
DUT

Expression for DUT Gene

mRNA expression in normal human tissues for DUT Gene

Protein differential expression in normal tissues from HIPED for DUT Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUT Gene



SOURCE GeneReport for Unigene cluster for DUT Gene Hs.527980

mRNA Expression by UniProt/SwissProt for DUT Gene

P33316-DUT_HUMAN
Tissue specificity: Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).
genes like me logo Genes that share expression patterns with DUT: view

Protein tissue co-expression partners for DUT Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DUT Gene

Orthologs for DUT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUT 35
  • 89.41 (n)
  • 90.54 (a)
-- 36
  • 82 (a)
OneToMany
DUT 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DUT 35
  • 84.66 (n)
  • 85.45 (a)
DUT 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dut 35
  • 81.53 (n)
  • 87.26 (a)
Dut 16
Dut 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUT 35
  • 98.94 (n)
  • 97.62 (a)
DUT 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dut 35
  • 80.86 (n)
  • 88.39 (a)
oppossum
(Monodelphis domestica)
Mammalia DUT 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves DUT 35
  • 75.97 (n)
  • 87.01 (a)
DUT 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUT 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733437 35
  • 66.28 (n)
  • 73.84 (a)
Str.1294 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7472 35
zebrafish
(Danio rerio)
Actinopterygii dut 35
  • 65.4 (n)
  • 73.42 (a)
wufa28d11 35
dut 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2007 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010159 35
  • 65.95 (n)
  • 73.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta dUTPase 35
  • 58.96 (n)
  • 65.31 (a)
dUTPase 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K07A1.2 37
  • 58 (a)
dut-1 35
  • 57.17 (n)
  • 60.61 (a)
dut-1 36
  • 21 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR249C 35
  • 54.5 (n)
  • 53.38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DUT1 36
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2142 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToMany
CSA.6436 36
  • 62 (a)
OneToMany
Species with no ortholog for DUT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUT Gene

ENSEMBL:
Gene Tree for DUT (if available)
TreeFam:
Gene Tree for DUT (if available)

Paralogs for DUT Gene

genes like me logo Genes that share paralogs with DUT: view

No data available for Paralogs for DUT Gene

Variants for DUT Gene

Sequence variations from dbSNP and Humsavar for DUT Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs28381104 - 48,332,285(+) TTTCA(C/T)CCAGT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1224420 -- 48,336,829(-) CCATA(A/G)AGCAG intron-variant
rs1237834 -- 48,340,048(-) AGCTG(A/G)GAAAA intron-variant
rs1237835 -- 48,336,863(-) TCTAA(A/G)CCAGT intron-variant
rs1802838 -- 48,342,044(+) AAGGG(G/T)TTCAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DUT Gene

Variant ID Type Subtype PubMed ID
dgv746e1 CNV Complex 17122850

Variation tolerance for DUT Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUT Gene

HapMap Linkage Disequilibrium report
DUT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUT Gene

Disorders for DUT Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUT Gene - From: GeneCards

Disorder Aliases PubMed IDs
cysticercosis
  • taeniasis
- elite association - COSMIC cancer census association via MalaCards
Search DUT in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUT

Genetic Association Database (GAD)
DUT
Human Genome Epidemiology (HuGE) Navigator
DUT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUT
genes like me logo Genes that share disorders with DUT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUT Gene

Publications for DUT Gene

  1. Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme. (PMID: 1325640) McIntosh E.M. … Haynes R.H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization. (PMID: 9070952) Cohen D. … Pearlman R.E. (Genomics 1997) 2 3 23
  3. Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases. (PMID: 19879316) Quesada-Soriano I. … GarcA-a-Fuentes L. (Biochimie 2010) 3 23
  4. dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma. (PMID: 19968781) Takatori H. … Kaneko S. (Liver Int. 2010) 3 23
  5. Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. (PMID: 19015155) Wilson P.M. … Ladner R.D. (Nucleic Acids Res. 2009) 3 23

Products for DUT Gene

Sources for DUT Gene

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