DUT Gene

Aliases
for DUT gene

Previous GC identifers: GC15P044181 GC15P041669 GC15P046202 GC15P046339 GC15P046410 GC15P025461

Summaries
for DUT gene

Genomic Views
for DUT gene

RefSeq DNA sequence:

NC_000015.9  NC_018926.1  NT_010194.17  

SwitchGear Promoter luciferase reporter plasmids (see all 3): DUT promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUT

DUT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P048623:  view genomic region     (about GC identifiers)

Proteins
for DUT gene

6 PDB 3D structures from and Proteopedia for DUT:

1Q5H (3D)        1Q5U (3D)        2HQU (3D)        3ARA (3D)        3ARN (3D)        3EHW (3D)    

Explore the universe of human proteins at neXtProt for DUT: NX_P33316

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): DUT OriGene Custom Protein Services for DUT
	GenScript Custom Purified and Recombinant Proteins Services for DUT
	Novus Biologicals DUT Proteins Novus Biologicals DUT Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DUT
	Uscn Proteins for DUT

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DUT
	GenScript Custom Superior Antibodies Services for DUT
	Novus Biologicals DUT Antibodies
	Abcam antibodies for DUT
	Uscn Antibodies for DUT
	ThermoFisher Antibodies for DUT

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DUT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DUT

Protein Domains /
Families
for DUT gene

ProtoNet protein and cluster: P33316

Function
for DUT gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): DUT Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUT
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate DUT:
		hsa-miR-374b* hsa-miR-203 hsa-miR-2115 hsa-miR-3658
		SwitchGear 3'UTR luciferase reporter plasmid: DUT 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUT (see all 4) OriGene shRNA RFP: DUT OriGene siRNA: DUT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUT

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DUT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUT (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUT (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): DUT (NM_001025248)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DUT
		Search LifeMap BioReagents cell lines for DUT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUT

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for DUT gene

	Super-pathway	contained gene-specific pathways
1	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
2	Pyrimidine metabolism	Pyrimidine metabolism 1.00
3	Pyrimidine biosynthesis	Pyrimidine biosynthesis 1.00
4	pyrimidine ribonucleotides interconversion	pyrimidine deoxyribonucleotides de novo biosynthesis I 0.50
5	Purine metabolism	Metabolism of nucleotides 0.42

1 BioSystems Pathway for DUT

pyrimidine deoxyribonucleotides de novo biosynthesis I

4        Reactome Pathways for DUT

	Metabolism of nucleotides
	Metabolism
	Pyrimidine metabolism
	Pyrimidine biosynthesis

2         Kegg Pathways  (Kegg details for DUT)

	Pyrimidine metabolism
	Metabolic pathways

DUT for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DUT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/59 Interacting proteins for DUT (P33316^{1, 2, 3} ENSP00000370376⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for DUT gene

Transcripts
for DUT gene

Expression
for DUT gene

DUT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCTCCGCT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUT
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUT

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUT

Orthologs
for DUT gene

Paralogs
for DUT gene

Paralogs for DUT gene

DUT for paralogs           About GeneDecksing


5/9 Pseudogenes.org Pseudogenes for DUT (see all 9)
PGOHUM00000262119 PGOHUM00000245069 PGOHUM00000238159 PGOHUM00000262001 PGOHUM00000246007

Genomic Variants
for DUT gene

10/226 NCBI SNPs in DUT are shown (see all 226)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs80399671,2	A	--	25455091(+)	aaaaaA/Caaaaa	2	--	us2k1		0	--	--	--	--
rs80399711,2	A	--	25455097(+)	aaaaaA/CTATGA	2	--	us2k1		0	--	--	--	--
rs80411821,2	A	--	25455098(+)	aaaaCA/TATGAA	2	--	us2k1		0	--	--	--	--
rs740145131,2	C,	--	25455431(+)	TCATAA/CAAGTT	3	--	us2k1		2		WA	120
rs80241621,2	A,H	--	25455495(+)	AATGAA/GAGTAT	3	--	us2k1		4		NS EA	416
rs80254821,2	A,H	--	25455516(+)	ACTAAT/CGAATG	3	--	us2k1		4		NS EA	418
rs71633151,2	C,F,H,	--	25455627(+)	GAAGTC/GGTTAC	3	--	us2k1		11		NS EA WA	726
rs283810891,2	F	--	25455652(+)	AGTAC-/TACAAGCA	3	--	us2k1		5		NS	188
rs283810921,2	C,	--	25456219(+)	AGGATA/TGTAGC	3	--	us2k1		5		NS	184
rs283810941,2	C,F,	--	25456341(+)	GCGCCG/ACTAAA	3	--	us2k1		5		NS	188

HapMap Linkage Disequilibrium report for DUT (48623208 - 48635570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DUT
     1 CNV: 3962

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUT

DNA2.0 Custom Variant and Variant Library Synthesis for DUT

Disorders / Diseases
for DUT gene

20/25 diseases for DUT

10/11 Novoseek disease relationships for DUT gene (see all 11)    About this table

Publications
for DUT gene

PubMed articles for DUT gene, integrated from 9 sources (see all 149): (articles sorted by number of sources associating them with DUT)

Utopia: connect your pdf to the dynamic world of online information

1. Human dUTP pyrophosphatase: cDNA sequence and potential biological importance of the enzyme. (PubMed id 1325640)^{1, 2, 3, 9} McIntosh E.M.... Haynes R.H. (1992)
2. Assignment of the human dUTPase gene (DUT) to chromosome 15q15-q21. 1 by fluorescence in situ hybridization. (PubMed id 9070952)^{1, 2, 3, 9} Cohen D....Pearlman R.E. (1997)
3. Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase. (PubMed id 8631817)^{1, 2, 9} Ladner R.D....Caradonna S.J. (1996)
4. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. (PubMed id 8805593)^{1, 2, 9} Mol C.D.... Tainer J.A. (1996)
5. Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase. (PubMed id 8631816)^{1, 2, 9} Ladner R.D.... Caradonna S.J. (1996)
6. Maturation stage and proliferation-dependent expression of dUTPase in human T cells. (PubMed id 8389461)^{1, 2, 9} Strahler J.R.... Hanash S.M. (1993)
7. The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species. (PubMed id 9228092)^{1, 2, 9} Ladner R.D. and Caradonna S.J. (1997)
8. Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. (PubMed id 17880943)^{1, 2, 9} Varga B....Vertessy B.G. (2007)
9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

External Searches for DUT gene

Genome Databases showing DUT gene

Other Databases showing DUT gene

Specialized Databases showing DUT gene

Products
for DUT gene