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Aliases for DUSP9 Gene

Aliases for DUSP9 Gene

  • Dual Specificity Phosphatase 9 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 4 3 4
  • Map Kinase Phosphatase 4 2 3
  • MKP-4 3 4
  • MKP4 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • MAP Kinase Phosphatase 4 4
  • EC 4
  • EC 4

External Ids for DUSP9 Gene

Previous GeneCards Identifiers for DUSP9 Gene

  • GC0XP147045
  • GC0XP149362
  • GC0XP150493
  • GC0XP151375
  • GC0XP152428
  • GC0XP152561
  • GC0XP152907
  • GC0XP141570

Summaries for DUSP9 Gene

Entrez Gene Summary for DUSP9 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for DUSP9 Gene

DUSP9 (Dual Specificity Phosphatase 9) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP9 Gene

  • Inactivates MAP kinases. Has a specificity for the ERK family.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP9 Gene

Genomics for DUSP9 Gene

Regulatory Elements for DUSP9 Gene

Enhancers for DUSP9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUSP9 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP9 Gene

153,642,443 bp from pter
153,651,326 bp from pter
8,884 bases
Plus strand

Genomic View for DUSP9 Gene

Genes around DUSP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP9 Gene

Proteins for DUSP9 Gene

  • Protein details for DUSP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 9
    Protein Accession:
    Secondary Accessions:
    • D3DWU5

    Protein attributes for DUSP9 Gene

    384 amino acids
    Molecular mass:
    41868 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP9 Gene

neXtProt entry for DUSP9 Gene

Proteomics data for DUSP9 Gene at MOPED

Post-translational modifications for DUSP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DUSP9 Gene

Domains & Families for DUSP9 Gene

Gene Families for DUSP9 Gene

Suggested Antigen Peptide Sequences for DUSP9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP9: view

Function for DUSP9 Gene

Molecular function for DUSP9 Gene

GENATLAS Biochemistry:
dual specific (tyr/thr) phosphatase 9,only expressed in placenta,kidney,embryonic liver
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Inactivates MAP kinases. Has a specificity for the ERK family.

Enzyme Numbers (IUBMB) for DUSP9 Gene

Gene Ontology (GO) - Molecular Function for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP9: view
genes like me logo Genes that share phenotypes with DUSP9: view

Animal Models for DUSP9 Gene

MGI Knock Outs for DUSP9:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP9 Gene

Localization for DUSP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP9 Gene


Subcellular locations from

Jensen Localization Image for DUSP9 Gene COMPARTMENTS Subcellular localization image for DUSP9 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP9 Gene

Pathways & Interactions for DUSP9 Gene

SuperPathways for DUSP9 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by GPCR
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP9: view

Pathways by source for DUSP9 Gene

SIGNOR curated interactions for DUSP9 Gene


Gene Ontology (GO) - Biological Process for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0006470 protein dephosphorylation IEA,TAS 9030581
GO:0007254 JNK cascade TAS 9030581
genes like me logo Genes that share ontologies with DUSP9: view

Drugs & Compounds for DUSP9 Gene

(4) Additional Compounds for DUSP9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DUSP9: view

Transcripts for DUSP9 Gene

Unigene Clusters for DUSP9 Gene

Dual specificity phosphatase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP9 Gene

No ASD Table

Relevant External Links for DUSP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP9 Gene

mRNA expression in normal human tissues for DUSP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP9 Gene

This gene is overexpressed in Kidney - Cortex (x25.6).

Protein differential expression in normal tissues from HIPED for DUSP9 Gene

This gene is overexpressed in Fetal Liver (37.9), Fetal testis (14.2), and Fetal ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP9 Gene

SOURCE GeneReport for Unigene cluster for DUSP9 Gene Hs.744909

genes like me logo Genes that share expression patterns with DUSP9: view

Protein tissue co-expression partners for DUSP9 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DUSP9 Gene

Orthologs for DUSP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP9 35
  • 88.68 (n)
  • 91.58 (a)
DUSP9 36
  • 92 (a)
(Canis familiaris)
Mammalia DUSP9 35
  • 89.04 (n)
  • 92.11 (a)
DUSP9 36
  • 93 (a)
(Mus musculus)
Mammalia Dusp9 35
  • 84.71 (n)
  • 85.99 (a)
Dusp9 16
Dusp9 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Dusp9 35
  • 81.42 (n)
  • 82.03 (a)
(Monodelphis domestica)
Mammalia DUSP9 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP9 36
  • 62 (a)
(Pan troglodytes)
Mammalia DUSP9 36
  • 98 (a)
(Anolis carolinensis)
Reptilia DUSP9 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493388 35
  • 63.23 (n)
  • 65.18 (a)
(Danio rerio)
Actinopterygii si:ch211-195b15.8 36
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 37
  • 39 (a)
Mkp3 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea lip-1 37
  • 48 (a)
lip-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 36
  • 36 (a)
Species with no ortholog for DUSP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP9 Gene

Gene Tree for DUSP9 (if available)
Gene Tree for DUSP9 (if available)

Paralogs for DUSP9 Gene

Paralogs for DUSP9 Gene

(10) SIMAP similar genes for DUSP9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP9: view

Variants for DUSP9 Gene

Sequence variations from dbSNP and Humsavar for DUSP9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1894299 -- 153,643,433(+) CTTGG(A/G)CCCCC intron-variant, upstream-variant-2KB
rs2301142 -- 153,642,698(+) CCTGC(A/G)CCCCC intron-variant, upstream-variant-2KB
rs3761534 -- 153,642,097(-) CTAGG(C/T)GGACG upstream-variant-2KB
rs3761535 -- 153,641,579(-) TGAGC(A/C/G)AGTGT upstream-variant-2KB
rs3761536 -- 153,640,838(-) TGAAG(A/T)TACGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP9 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv2666278 CNV Deletion 23128226

Variation tolerance for DUSP9 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUSP9 Gene

Disorders for DUSP9 Gene

Relevant External Links for DUSP9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUSP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP9 Gene

Publications for DUSP9 Gene

  1. Molecular cloning and functional characterization of a novel mitogen- activated protein kinase phosphatase, MKP-4. (PMID: 9030581) Muda M. … Arkinstall S. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Development of a DUSP9 methylation screening assay. (PMID: 24838152) Jenner S. … Techel D. (Pathol. Oncol. Res. 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Epigenetic silencing of DUSP9 induces the proliferation of human gastric cancer by activating JNK signaling. (PMID: 25998184) Wu F. … Zhi F.C. (Oncol. Rep. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DUSP9 Gene

Sources for DUSP9 Gene