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Aliases for DUSP9 Gene

Aliases for DUSP9 Gene

  • Dual Specificity Phosphatase 9 2 3
  • MKP4 3 4 6
  • Mitogen-Activated Protein Kinase Phosphatase 4 3 4
  • Map Kinase Phosphatase 4 2 3
  • MKP-4 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 9 3
  • MAP Kinase Phosphatase 4 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP9 Gene

Summaries for DUSP9 Gene

Entrez Gene Summary for DUSP9 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP9 Gene

DUSP9 (Dual Specificity Phosphatase 9) is a Protein Coding gene. Diseases associated with DUSP9 include renal cell carcinoma. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP9 Gene

  • Inactivates MAP kinases. Has a specificity for the ERK family

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP9 Gene

Genomics for DUSP9 Gene

Genomic Location for DUSP9 Gene

Start:
153,642,443 bp from pter
End:
153,651,326 bp from pter
Size:
8,884 bases
Orientation:
Plus strand

Genomic View for DUSP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP9 Gene

Regulatory Elements for DUSP9 Gene

Proteins for DUSP9 Gene

  • Protein details for DUSP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99956-DUS9_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 9
    Protein Accession:
    Q99956
    Secondary Accessions:
    • D3DWU5

    Protein attributes for DUSP9 Gene

    Size:
    384 amino acids
    Molecular mass:
    41868 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP9 Gene

neXtProt entry for DUSP9 Gene

Proteomics data for DUSP9 Gene at MOPED

Post-translational modifications for DUSP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP9 Gene

Domains for DUSP9 Gene

Gene Families for DUSP9 Gene

HGNC:
  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

Suggested Antigen Peptide Sequences for DUSP9 Gene

Graphical View of Domain Structure for InterPro Entry

Q99956

UniProtKB/Swiss-Prot:

DUS9_HUMAN
Domain:
  • Contains 1 rhodanese domain.:
    • Q99956
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q99956
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • Q99956
genes like me logo Genes that share domains with DUSP9: view

Function for DUSP9 Gene

Molecular function for DUSP9 Gene

GENATLAS Biochemistry: dual specific (tyr/thr) phosphatase 9,only expressed in placenta,kidney,embryonic liver
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Inactivates MAP kinases. Has a specificity for the ERK family

Enzyme Numbers (IUBMB) for DUSP9 Gene

Gene Ontology (GO) - Molecular Function for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity TAS 9030581
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 11988087
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUSP9: view

Phenotypes for DUSP9 Gene

MGI mutant phenotypes for DUSP9:
inferred from 1 alleles
GenomeRNAi human phenotypes for DUSP9:
genes like me logo Genes that share phenotypes with DUSP9: view

Animal Models for DUSP9 Gene

MGI Knock Outs for DUSP9:

miRNA for DUSP9 Gene

miRTarBase miRNAs that target DUSP9

No data available for Transcription Factor Targeting and HOMER Transcription for DUSP9 Gene

Localization for DUSP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP9 Gene COMPARTMENTS Subcellular localization image for DUSP9 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9030581
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUSP9: view

Pathways for DUSP9 Gene

genes like me logo Genes that share pathways with DUSP9: view

Pathways by source for DUSP9 Gene

1 GeneGo (Thomson Reuters) pathway for DUSP9 Gene
1 Qiagen pathway for DUSP9 Gene
1 KEGG pathway for DUSP9 Gene

Gene Ontology (GO) - Biological Process for DUSP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation IBA --
GO:0007254 JNK cascade TAS 9030581
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP9: view

Compounds for DUSP9 Gene

(1) HMDB Compounds for DUSP9 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2

(1) Novoseek inferred chemical compound relationships for DUSP9 Gene

Compound -log(P) Hits PubMed IDs
p-nitrophenyl phosphate 79.6 1
genes like me logo Genes that share compounds with DUSP9: view

Transcripts for DUSP9 Gene

Unigene Clusters for DUSP9 Gene

Dual specificity phosphatase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP9 Gene

No ASD Table

Relevant External Links for DUSP9 Gene

GeneLoc Exon Structure for
DUSP9
ECgene alternative splicing isoforms for
DUSP9

Expression for DUSP9 Gene

mRNA expression in normal human tissues for DUSP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP9 Gene

This gene is overexpressed in Kidney - Cortex (25.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP9 Gene

SOURCE GeneReport for Unigene cluster for DUSP9 Gene Hs.744909

genes like me logo Genes that share expressions with DUSP9: view

No data available for mRNA Expression by UniProt/SwissProt for DUSP9 Gene

Orthologs for DUSP9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP9 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP9 35
  • 88.68 (n)
  • 91.58 (a)
DUSP9 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP9 35
  • 89.04 (n)
  • 92.11 (a)
DUSP9 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp9 35
  • 84.71 (n)
  • 85.99 (a)
Dusp9 16
Dusp9 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP9 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP9 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp9 35
  • 81.42 (n)
  • 82.03 (a)
lizard
(Anolis carolinensis)
Reptilia DUSP9 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493388 35
  • 63.23 (n)
  • 65.18 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-195b15.8 36
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 36
  • 33 (a)
OneToMany
Mkp3 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea lip-1 36
  • 28 (a)
OneToMany
lip-1 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 36
  • 36 (a)
OneToMany
Species with no ortholog for DUSP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP9 Gene

ENSEMBL:
Gene Tree for DUSP9 (if available)
TreeFam:
Gene Tree for DUSP9 (if available)

Paralogs for DUSP9 Gene

Paralogs for DUSP9 Gene

Selected SIMAP similar genes for DUSP9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP9: view

Variants for DUSP9 Gene

Sequence variations from dbSNP and Humsavar for DUSP9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1894299 -- 153,643,433(+) CTTGG(A/G)CCCCC intron-variant
rs2301142 -- 153,642,698(+) CCTGC(A/G)CCCCC intron-variant
rs3761534 -- 153,642,097(-) CTAGG(C/T)GGACG upstream-variant-2KB
rs3761535 -- 153,641,579(-) TGAGC(C/G)AGTGT upstream-variant-2KB
rs3761536 -- 153,640,838(-) TGAAG(A/T)TACGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP9 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv2666278 CNV Deletion 23128226

Relevant External Links for DUSP9 Gene

HapMap Linkage Disequilibrium report
DUSP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP9 Gene

Disorders for DUSP9 Gene

(1) MalaCards Diseases for DUSP9 Gene

Search for DUSP9 Gene in MalaCards »

Relevant External Links for DUSP9

Genetic Association Database (GAD)
DUSP9
Human Genome Epidemiology (HuGE) Navigator
DUSP9
genes like me logo Genes that share disorders with DUSP9: view

No data available for UniProtKB/Swiss-Prot for DUSP9 Gene

Publications for DUSP9 Gene

  1. Molecular cloning and functional characterization of a novel mitogen- activated protein kinase phosphatase, MKP-4. (PMID: 9030581) Muda M. … Arkinstall S. (J. Biol. Chem. 1997) 2 3 4 23
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight B.F. … . (Nat. Genet. 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4. (PMID: 21206059) Jeong D.G. … Kim S.J. (Acta Crystallogr. D Biol. Crystallogr. 2011) 3

Products for DUSP9 Gene

Sources for DUSP9 Gene

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