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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP9 Gene

protein-coding   GIFtS: 61
GCID: GC0XP152907

dual specificity phosphatase 9
 Explore 5 diseases affiliated with
DUSP9 via
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Biological research products
for DUSP9    

Aliases
for DUSP9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dual Specificity Phosphatase 91 2     Dual Specificity Protein Phosphatase 92
MKP-41 2 3     Serine/Threonine Specific Protein Phosphatase2
MKP41 2 3     EC 3.1.3.163
MAP Kinase Phosphatase 42 3     EC 3.1.3.483
Mitogen-Activated Protein Kinase Phosphatase 42 3     

External Ids:    HGNC: 30761   Entrez Gene: 18522   Ensembl: ENSG000001308297   OMIM: 3001345   UniProtKB: Q999563   

Export aliases for DUSP9 gene to outside databases

Previous GC identifers: GC0XP147045 GC0XP149362 GC0XP150493 GC0XP151375 GC0XP152428 GC0XP152561 GC0XP141570


Summaries
for DUSP9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUSP9:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.
They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),
which is associated with cellular proliferation and differentiation. Different members of the family of dual
specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution
and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This
gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney,
and fetal liver, and is localized to the cytoplasm and nucleus. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956
Function: Inactivates MAP kinases. Has a specificity for the ERK family




Genomic Views
for DUSP9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP9 gene promoter:
         GCNF   NRSF form 1   CUTL1   NRSF form 2   Meis-1b   GATA-2   GCNF-1   Meis-1a   GCNF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DUSP9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

DUSP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP9 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152907:  view genomic region     (about GC identifiers)

Start:
 152,907,897 bp from pter      End:
 152,916,781 bp from pter
Size:
 8,885 bases      Orientation:
 plus strand

Proteins
for DUSP9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 9  
Size: 384 amino acids; 41868 Da
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for DUSP9:
2HXP (3D)        3LJ8 (3D)    
Secondary accessions: D3DWU5

Explore the universe of human proteins at neXtProt for DUSP9: NX_Q99956

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99956

    • DUSP9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001386.1  
    ENSEMBL proteins: 
     ENSP00000359186   ENSP00000415557   ENSP00000345853  

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    Novus Biologicals DUSP9 Proteins
    Novus Biologicals DUSP9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DUSP9

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9030581
    GO:0005737cytoplasm TAS9030581
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol IBA--


    DUSP9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DUSP9

    Protein Domains /
    Families
    for DUSP9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DUSP9 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q99956

    ProtoNet protein and cluster: Q99956

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for DUSP9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956
    Function: Inactivates MAP kinases. Has a specificity for the ERK family
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP9:
    dual specific (tyr/thr) phosphatase 9,only expressed in placenta,kidney,embryonic liver

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP9
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP9 (see all 39):
    hsa-miR-576-3p hsa-miR-548j hsa-let-7d hsa-miR-1245 hsa-miR-3142 hsa-let-7g hsa-miR-1184 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP9 (see all 7)
    OriGene shRNA RFP: DUSP9
    OriGene siRNA: DUSP9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP9

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DUSP9

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP9 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP9 

    Cell Line
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    Search LifeMap BioReagents cell lines for DUSP9

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS9030581
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--


    DUSP9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DUSP9:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-out Dusp9tm1Skey for DUSP9
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dusp9):
     embryogenesis  mortality/aging 

    DUSP9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DUSP9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Erk Interactions: Inhibition of Erk
    		Signal transduction Erk Interactions: Inhibition of Erk1.00
    		Signal transduction_Erk Interactions- Inhibition of Erk0.92
    2TGF-Beta Pathway
    		JNK Pathway0.50
    3MAPK signaling pathway
    		MAPK signaling pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for DUSP9
        Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP9
        JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for DUSP9
        Signal transduction Erk Interactions- Inhibition of Erk


    1         Kegg Pathway  (Kegg details for DUSP9):
        MAPK signaling pathway


    DUSP9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for DUSP9 (Q999562, 3 ENSP000003458534) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8287219 MINT-8287238 I2D: score=2 STRING: ENSP00000215832
    MAPK14Q165392, 3, ENSP000002297944MINT-8287227 MINT-8287259 MINT-8287212 I2D: score=2 STRING: ENSP00000229794
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MAPK10ENSP000003521574STRING: ENSP00000352157
    MAPK11ENSP000003336854STRING: ENSP00000333685
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0007254JNK cascade TAS9030581


    DUSP9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUSP9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP9

    1 HMDB Compound for DUSP9    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    1 Novoseek chemical compound relationship for DUSP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    p-nitrophenyl phosphate 79.6 1 9030581 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP9 / DUS9 

    Transcripts
    for DUSP9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUSP9 gene: 
    NM_001395.2  

    Unigene Cluster for DUSP9:

    Dual specificity phosphatase 9
    Hs.144879  [show with all ESTs]
    Unigene Representative Sequence: BC060837
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477033 ENST00000370167(uc004fhx.4) ENST00000433144 ENST00000342782(uc004fhy.4)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP9
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP9 (see all 39):
    hsa-miR-576-3p hsa-miR-548j hsa-let-7d hsa-miR-1245 hsa-miR-3142 hsa-let-7g hsa-miR-1184 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP9 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP9 (see all 7)
    OriGene shRNA RFP: DUSP9
    OriGene siRNA: DUSP9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP9
    Clone
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    GenScript: all cDNA clones in your preferred vector: DUSP9 (NM_001395)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP9

    Additional cDNA sequence: 

    AK314250.1 BC034936.1 BC042166.1 BC060837.1 U87167.1 Y08302.1 

    6 DOTS entries:

    DT.97780684  DT.100748875  DT.100752137  DT.97765738  DT.100768531  DT.91747356 

    24/111 AceView cDNA sequences (see all 111):

    BQ652473 BX439704 BU180919 U87167 AW235800 AI367247 BM910652 AA653584 
    BM910756 AI253132 CB995169 R13308 BE326643 AI473721 AW271700 AI806537 
    AI434619 AI434422 CR622905 BQ064578 AW024965 NM_001395 AW024975 BQ648281 

    GeneLoc Exon Structure


    Expression
    for DUSP9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAGCCCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DUSP9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DUSP9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP9

    SOURCE GeneReport for Unigene cluster: Hs.144879
        SABiosciences Expression via Pathway-Focused PCR Array including DUSP9: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP9

    Orthologs
    for DUSP9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP9 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DUSP96
    		 --
    		 74(a)
    		 1 ↔ 1
    		 2(87083224-87100896)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mkp33 protein amino acid dephosphorylation protein
    tyrosine/serine/threonine more    		 39(a)   75F6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea lip-13 protein-tyrosine phosphatase 48(a)   IV(6843152-6845014)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DSPTP11 dual specificity protein phosphatase 1 44.29(n)
    42.14(a)    		   821941  NM_001125211.2  NP_001118683.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g03909001 hypothetical protein 47.68(n)
    42.38(a)    		   4325232  NM_001049647.1  NP_001043112.1 


    ENSEMBL Gene Tree for DUSP9 (if available)
    TreeFam Gene Tree for DUSP9 (if available) 

    Paralogs
    for DUSP9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP9 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP62  DUSP192  DUSP142  DUSP282  
    DUSP82  DUSP72  DUSP52  SSH32  DUSP162  DUSP22  DUSP182  SSH12  
    DUSP12  
    15 SIMAP similar genes for DUSP9 using alignment to 3 protein entries:     DUS9_HUMAN (see all proteins):
    DUSP6    DUSP7    DUSP13    DUSP22    DUSP14    STYX
    DUSP3    DUSP19    DUSP1    DUSP2    DUSP28    DUSP4
    DUSP10    DUSP18    DUSP8

    DUSP9 for paralogs           About GeneDecksing



    Genomic Variants
    for DUSP9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 NCBI SNPs in DUSP9 are shown (see all 117)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1853242041,2
    		--152905948(+) GCCTGA/GAGAGC 1 -- us2k10--------
    rs1894503761,2
    		--152906078(+) AGGGGA/GGGATG 1 -- us2k10--------
    rs736337031,2
    		C,--152906103(+) TAGAAA/GCTCCT 1 -- us2k12Minor allele frequency- G:0.00WA 4
    rs37615361,2
    		C,F,A,H,--152906292(-) TGAAGA/TTACGG 1 -- us2k129--NS EA NA 3138
    rs726164471,2
    		C,--152906326(+) AGTGGG/CAGCTG 1 -- us2k11Minor allele frequency- C:0.00NA 1
    rs1864905831,2
    		--152906486(+) GCTCCC/TAGGAG 1 -- us2k10--------
    rs1881762041,2
    		--152906667(+) CCAAAC/TGTACA 1 -- us2k10--------
    rs1809847841,2
    		--152906923(+) AGGCAC/GGAGGC 1 -- us2k10--------
    rs37888041,2
    		C,F,H,--152906933(-) TATGAG/ACCCGG 1 -- us2k19Minor allele frequency- A:0.05NS EA NA 1210
    rs1864600141,2
    		--152906953(+) TCTGGA/GAGCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUSP9 (152907897 - 152916781 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DUSP9: --

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    Disorders / Diseases
    for DUSP9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUSP9 for disorders           About GeneDecksing

    OMIM gene information: 300134    OMIM disorders: --

    5 diseases for DUSP9:    About MalaCards
    clear cell renal cell carcinoma    renal cell carcinoma    prostate cancer    carcinoma
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: DUSP9 (4 documents)

    Export disorders for DUSP9 gene to outside databases

    Publications
    for DUSP9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP9 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with DUSP9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a novel mitogen- activated protein kinase phosphatase, MKP-4. (PubMed id 9030581)1, 2, 3, 9 Muda M.... Arkinstall S. (1997)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. A single nucleotide polymorphism within DUSP9 is assoc iated with susceptibility to type 2 diabetes in a Japanese population. (PubMed id 23029454)1 Fukuda H....Maeda S. (2012)
    4. Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma. (PubMed id 21943117)1 Wu S....Zhou F. (2011)
    5. Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4. (PubMed id 21206059)1 Jeong D.G....Kim S.J. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Phosphorylation of the kinase interaction motif in mi togen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. (PubMed id 21908610)1 Dickinson R.J....Keyse S.M. (2011)
    10. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1 Voight B.F.... . (2010)

    External Searches for DUSP9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing DUSP9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1852 HGNC: 3076 AceView: DUSP9 Ensembl:ENSG00000130829 euGenes: HUgn1852
    ECgene: DUSP9 Kegg: 1852 H-InvDB: DUSP9

    Other Databases showing DUSP9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUSP9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DUSP9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUSP9 gene:
    Search GeneIP for patents involving DUSP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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