Aliases for DUSP9 Gene
External Ids for DUSP9 Gene
Previous GeneCards Identifiers for DUSP9 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for DUSP9 Gene
DUSP9 (Dual Specificity Phosphatase 9) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot for DUSP9 Gene
Inactivates MAP kinases. Has a specificity for the ERK family.