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DUSP9 Gene

protein-coding   GIFtS: 60
GCID: GC0XP152907

Dual Specificity Phosphatase 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 91 2     Dual Specificity Protein Phosphatase 92
MAP Kinase Phosphatase 41 2 3     Serine/Threonine Specific Protein Phosphatase2
MKP42 3 5     EC 3.1.3.163
Mitogen-Activated Protein Kinase Phosphatase 42 3     EC 3.1.3.483
MKP-42 3     

External Ids:    HGNC: 30761   Entrez Gene: 18522   Ensembl: ENSG000001308297   OMIM: 3001345   UniProtKB: Q999563   

Export aliases for DUSP9 gene to outside databases

Previous GC identifers: GC0XP147045 GC0XP149362 GC0XP150493 GC0XP151375 GC0XP152428 GC0XP152561 GC0XP141570


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP9 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the
ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the
cytoplasm and nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP9 Gene:
DUSP9 (dual specificity phosphatase 9) is a protein-coding gene. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956
Function: Inactivates MAP kinases. Has a specificity for the ERK family




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP9 gene promoter:
         GCNF   NRSF form 1   CUTL1   NRSF form 2   Meis-1b   GATA-2   GCNF-1   Meis-1a   GCNF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP9 promoter sequence
   Search Chromatin IP Primers for DUSP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

DUSP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP9 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP152907:  view genomic region     (about GC identifiers)

Start:
152,907,897 bp from pter      End:
152,916,781 bp from pter
Size:
8,885 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 9  
Size: 384 amino acids; 41868 Da
2 PDB 3D structures from and Proteopedia for DUSP9:
2HXP (3D)        3LJ8 (3D)    
Secondary accessions: D3DWU5

Explore the universe of human proteins at neXtProt for DUSP9: NX_Q99956

Explore proteomics data for DUSP9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001386.1  
    ENSEMBL proteins: 
     ENSP00000359186   ENSP00000345853  

    DUSP9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DUSP9

     
    Search eBioscience for Proteins for DUSP9 

     
    antibodies-online proteins for DUSP9 (5 products) 

     
    antibodies-online peptides for DUSP9

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    antibodies-online antibodies for DUSP9 (36 products) 

    DUSP9 Assay Products:

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    Cloud-Clone Corp. ELISAs for DUSP9
    Cloud-Clone Corp. CLIAs for DUSP9
    Search eBioscience for ELISAs for DUSP9 
    antibodies-online kits for DUSP9 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 6):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q99956

    ProtoNet protein and cluster: Q99956

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS9_HUMAN, Q99956
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS9_HUMAN, Q99956
    Function: Inactivates MAP kinases. Has a specificity for the ERK family
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for DUSP9:
    dual specific (tyr/thr) phosphatase 9,only expressed in placenta,kidney,embryonic liver

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS9030581
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI11988087
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with DUSP9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DUSP9:
     Decreased nuclei size in G2M 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dusp9):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with DUSP9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dusp9tm1Skey for DUSP9

       genOway: Develop your customized and physiologically relevant rodent model for DUSP9

    miRNA
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    miRTarBase miRNAs that target DUSP9:
    hsa-mir-98-5p (MIRT027506)

    Block miRNA regulation of human, mouse, rat DUSP9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP9 (see all 39):
    hsa-miR-576-3p hsa-miR-548j hsa-let-7d hsa-miR-1245 hsa-miR-3142 hsa-let-7g hsa-miR-1184 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidDUSP9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DUSP9
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP9

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DUSP9 (NM_001395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP9

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS9_HUMAN, Q99956: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    nucleus4
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9030581
    GO:0005737cytoplasm TAS9030581
    GO:0005783endoplasmic reticulum ----
    GO:0005829cytosol IBA--

    Find genes that share ontologies with DUSP9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP9 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    3Signal transduction Erk Interactions Inhibition of Erk
    Signal transduction Erk Interactions Inhibition of Erk


    Find genes that share SuperPaths with DUSP9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DUSP9
        JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for DUSP9
        Signal transduction Erk Interactions- Inhibition of Erk


    1 Kegg Pathway  (Kegg details for DUSP9):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP9: 
              Protein Phosphatases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DUSP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for DUSP9 (Q999561, 2, 3 ENSP000003458534) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8287219 MINT-8287238 I2D: score=2 STRING: ENSP00000215832
    MAPK14Q165391, 2, 3, ENSP000002297944EBI-3906678,EBI-73946 MINT-8287227 MINT-8287259 MINT-8287212 I2D: score=2 STRING: ENSP00000229794
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MAPK10ENSP000003521574STRING: ENSP00000352157
    MAPK11ENSP000003336854STRING: ENSP00000333685
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0007254JNK cascade TAS9030581
    GO:0016311dephosphorylation ----

    Find genes that share ontologies with DUSP9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP9 (DUS9)

    1 HMDB Compound for DUSP9    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    1 Novoseek inferred chemical compound relationship for DUSP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    p-nitrophenyl phosphate 79.6 1 9030581 (1)



    Find genes that share compounds with DUSP9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP9 gene: 
    NM_001395.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477033 ENST00000370167(uc004fhx.4) ENST00000342782(uc004fhy.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DUSP9 (see all 39):
    hsa-miR-576-3p hsa-miR-548j hsa-let-7d hsa-miR-1245 hsa-miR-3142 hsa-let-7g hsa-miR-1184 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidDUSP9 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat DUSP9
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    Selected AceView cDNA sequences (see all 111):

    AI434619 AI473721 U87167 AI434422 BU180919 BM910756 AW271700 BE326643 
    AW235800 AI806537 BQ652473 BM910652 AI253132 R13308 BX439704 AI367247 
    CB995169 AA653584 CR622905 AW028488 BU839669 BQ643765 AU157516 BQ648281 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGCCCACT
    DUSP9 Expression
    About this image


    DUSP9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Kidney (Urinary System)
             Metanephros
    DUSP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP9 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP9: 
              Protein Phosphatases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp91 , 5 dual specificity phosphatase 91, 5 84.71(n)1
    85.99(a)1
      X (37.37 cM)5
    755901  NM_029352.31  NP_083628.31 
     736394195 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP96
    dual specificity phosphatase 9
    74(a)
    1 ↔ 1
    2(87080879-87101837)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004933881 dual specificity protein phosphatase 6-like 63.23(n)
    65.18(a)
      100493388  XM_002935512.2  XP_002935558.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-195b15.86
    si:ch211-195b15.8
    15(a)
    many ↔ many
    3(32540734-32544168) ENSDARG00000094836
    fruit fly
    (Drosophila melanogaster)
    Insecta Mkp33 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    39(a)   75F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea lip-13 protein-tyrosine phosphatase 48(a)   IV(6843152-6845014)   --


    ENSEMBL Gene Tree for DUSP9 (if available)
    TreeFam Gene Tree for DUSP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP9 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP22  
    DUSP82  DUSP12  SSH12  DUSP72  
    10 SIMAP similar genes for DUSP9 using alignment to 2 protein entries:     DUS9_HUMAN (see all proteins):
    DUSP6    DUSP7    DUSP13    DUSP22    DUSP14    STYX
    DUSP3    DUSP19    DUSP1    DUSP28

    Find genes that share paralogs with DUSP9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP9 (see all 151)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853242041,2
    --152905948(+) GCCTGA/GAGAGC 1 -- us2k10--------
    rs1894503761,2
    C--152906078(+) AGGGGA/GGGATG 1 -- us2k10--------
    rs736337031,2
    C,F--152906103(+) TAGAAA/GCTCCT 1 -- us2k12Minor allele frequency- G:0.00WA 4
    rs37615361,2
    C,F,A,H--152906292(-) TGAAGA/TTACGG 1 -- us2k129--NS EA NA 3138
    rs726164471,2
    C--152906326(+) AGTGGG/CAGCTG 1 -- us2k11Minor allele frequency- C:0.00NA 1
    rs1864905831,2
    --152906486(+) GCTCCC/TAGGAG 1 -- us2k10--------
    rs1881762041,2
    --152906667(+) CCAAAC/TGTACA 1 -- us2k10--------
    rs1809847841,2
    --152906923(+) AGGCAC/GGAGGC 1 -- us2k10--------
    rs37888041,2
    C,F,H--152906933(-) TATGAG/ACCCGG 1 -- us2k19Minor allele frequency- A:0.05NS EA NA 1210
    rs1864600141,2
    --152906953(+) TCTGGA/GAGCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUSP9 (152907897 - 152916781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DUSP9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666278CNV Deletion23128226
    esv33199CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300134    OMIM disorders: --


    Find genes that share disorders with DUSP9           About GenesLikeMe

    Genetic Association Database (GAD): DUSP9
    Human Genome Epidemiology (HuGE) Navigator: DUSP9 (4 documents)

    Export disorders for DUSP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP9 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with DUSP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a novel mitogen- activated protein kinase phosphatase, MKP-4. (PubMed id 9030581)1, 2, 3, 9 Muda M.... Arkinstall S. (J. Biol. Chem. 1997)
    2. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Genome-wide association study identifies three novel loci for type 2 diabetes. (PubMed id 23945395)1 Hara K....Kadowaki T. (Hum. Mol. Genet. 2014)
    5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    6. Dual specificity phosphatase 9 (DUSP9) expression is down-regulated in the severe pre-eclamptic placenta. (PubMed id 23276385)1 Czikk M.J....Kingdom J. (Placenta 2013)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. (PubMed id 22961080)1 Li H....Lin X. (Diabetes 2013)
    9. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    10. A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population. (PubMed id 23029454)1 Fukuda H....Maeda S. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1852 HGNC: 3076 AceView: DUSP9 Ensembl:ENSG00000130829 euGenes: HUgn1852
    ECgene: DUSP9 Kegg: 1852 H-InvDB: DUSP9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP9 gene:
    Search GeneIP for patents involving DUSP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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