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Aliases for DUSP8 Gene

Aliases for DUSP8 Gene

  • Dual Specificity Phosphatase 8 2 3 5
  • Serine/Threonine Specific Protein Phosphatase 2 3
  • Dual Specificity Protein Phosphatase HVH-5 3 4
  • C11orf81 3 4
  • H1 Phosphatase, Vaccinia Virus Homolog 3
  • Chromosome 11 Open Reading Frame 81 2
  • Vaccinia Virus Homolog 2
  • H1 Phosphatase 2
  • EC 4
  • EC 4
  • HVH-5 3
  • HVH8 3
  • HB5 3
  • VH5 4

External Ids for DUSP8 Gene

Previous HGNC Symbols for DUSP8 Gene

  • C11orf81

Previous GeneCards Identifiers for DUSP8 Gene

  • GC11U990030
  • GC11M001539
  • GC11M001544
  • GC11M001533
  • GC11M001368

Summaries for DUSP8 Gene

Entrez Gene Summary for DUSP8 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP8 Gene

DUSP8 (Dual Specificity Phosphatase 8) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP8 Gene

  • This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP8 Gene

Genomics for DUSP8 Gene

Regulatory Elements for DUSP8 Gene

Enhancers for DUSP8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUSP8 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP8 Gene

1,554,044 bp from pter
1,572,831 bp from pter
18,788 bases
Minus strand

Genomic View for DUSP8 Gene

Genes around DUSP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP8 Gene

Proteins for DUSP8 Gene

  • Protein details for DUSP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 8
    Protein Accession:
    Secondary Accessions:
    • Q86SS8

    Protein attributes for DUSP8 Gene

    625 amino acids
    Molecular mass:
    65827 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP8 Gene

neXtProt entry for DUSP8 Gene

Proteomics data for DUSP8 Gene at MOPED

Post-translational modifications for DUSP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP8 Gene

Domains & Families for DUSP8 Gene

Gene Families for DUSP8 Gene

Suggested Antigen Peptide Sequences for DUSP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP8: view

Function for DUSP8 Gene

Molecular function for DUSP8 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 8,vaccinia virus VH1-like 5,murine M3/6 homolog,mainly expressed in brain,lung,tighty linked to H19 but not imprinted,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.

Enzyme Numbers (IUBMB) for DUSP8 Gene

Gene Ontology (GO) - Molecular Function for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP8: view
genes like me logo Genes that share phenotypes with DUSP8: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP8 Gene

Localization for DUSP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DUSP8 Gene COMPARTMENTS Subcellular localization image for DUSP8 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP8 Gene

Pathways & Interactions for DUSP8 Gene

SuperPathways for DUSP8 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by GPCR
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP8: view

Pathways by source for DUSP8 Gene

SIGNOR curated interactions for DUSP8 Gene


Gene Ontology (GO) - Biological Process for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 7561881
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7561881
genes like me logo Genes that share ontologies with DUSP8: view

Drugs & Compounds for DUSP8 Gene

(1) Drugs for DUSP8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(3) Additional Compounds for DUSP8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DUSP8: view

Transcripts for DUSP8 Gene

Unigene Clusters for DUSP8 Gene

Dual specificity phosphatase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP8 Gene

No ASD Table

Relevant External Links for DUSP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP8 Gene

mRNA expression in normal human tissues for DUSP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP8 Gene

This gene is overexpressed in Platelet (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP8 Gene

SOURCE GeneReport for Unigene cluster for DUSP8 Gene Hs.41688

mRNA Expression by UniProt/SwissProt for DUSP8 Gene

Tissue specificity: Abundant in brain, heart and skeletal muscle.
genes like me logo Genes that share expression patterns with DUSP8: view

Protein tissue co-expression partners for DUSP8 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DUSP8 Gene

Orthologs for DUSP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia DUSP8 35
  • 87.8 (n)
  • 89.41 (a)
DUSP8 36
  • 94 (a)
(Mus musculus)
Mammalia Dusp8 35
  • 85.07 (n)
  • 90.23 (a)
Dusp8 16
Dusp8 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC746336 35
  • 96.46 (n)
  • 95.68 (a)
DUSP8 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Dusp8 35
  • 85.02 (n)
  • 89.58 (a)
(Bos Taurus)
Mammalia DUSP8 36
  • 85 (a)
(Monodelphis domestica)
Mammalia DUSP8 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP8 36
  • 95 (a)
(Gallus gallus)
Aves DUSP8 35
  • 72.09 (n)
  • 71.87 (a)
DUSP8 36
  • 71 (a)
(Anolis carolinensis)
Reptilia DUSP8 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18203 35
(Danio rerio)
Actinopterygii -- 35
dusp8a 35
  • 61.73 (n)
  • 58.57 (a)
DUSP8 (2 of 2) 36
  • 47 (a)
dusp8a 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea vhp-1 37
  • 44 (a)
vhp-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for DUSP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP8 Gene

Gene Tree for DUSP8 (if available)
Gene Tree for DUSP8 (if available)

Paralogs for DUSP8 Gene

Paralogs for DUSP8 Gene

(11) SIMAP similar genes for DUSP8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP8: view

Variants for DUSP8 Gene

Sequence variations from dbSNP and Humsavar for DUSP8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs902222 -- 1,569,436(+) TTACC(C/T)ACAAT intron-variant, utr-variant-5-prime
rs902223 -- 1,569,437(+) TACCC(A/G)CAATC intron-variant, utr-variant-5-prime
rs902224 -- 1,569,679(+) AGGCC(A/T)CCCCC intron-variant, utr-variant-5-prime
rs902225 -- 1,569,856(+) ACCCA(A/G)GGATG intron-variant, utr-variant-5-prime
rs2008493 -- 1,561,410(-) CAGGG(A/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP8 Gene

Variant ID Type Subtype PubMed ID
dgv968n71 CNV Loss 21882294
dgv973n71 CNV Loss 21882294
nsv896708 CNV Loss 21882294
nsv896709 CNV Loss 21882294
dgv977n71 CNV Loss 21882294
dgv978n71 CNV Loss 21882294
nsv7641 CNV Insertion 18451855

Variation tolerance for DUSP8 Gene

Gene Damage Index Score: 1.06; 21.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUSP8 Gene

Disorders for DUSP8 Gene

Relevant External Links for DUSP8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUSP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP8 Gene

Publications for DUSP8 Gene

  1. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. (PMID: 7561881) Martell K.J. … Dixon J.E. (J. Neurochem. 1995) 2 3 4 67
  2. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (PMID: 9192849) Nesbit M.A. … Davies K.E. (Genomics 1997) 2 3 23
  3. Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2. (PMID: 15899389) Berger I.R. … Ullrich A. (Cancer Genet. Cytogenet. 2005) 3 23
  4. Investigation of DUSP8 and CALCA in alcohol dependence. (PMID: 13129832) Hink R.L. … Sikela J.M. (Addict Biol 2003) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DUSP8 Gene

Sources for DUSP8 Gene