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DUSP8 Gene

protein-coding   GIFtS: 57
GCID: GC11M001531

Dual Specificity Phosphatase 8

(Previous name: chromosome 11 open reading frame 81)
(Previous symbol: C11orf81)
  See DUSP8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 81 2     HB52
C11orf811 2 3     HVH-52
Serine/Threonine Specific Protein Phosphatase1 2     Dual Specificity Protein Phosphatase 82
Dual Specificity Protein Phosphatase HVH-52 3     H1 Phosphatase, Vaccinia Virus Homolog2
HVH82 5     EC 3.1.3.163
Chromosome 11 Open Reading Frame 811     EC 3.1.3.483
H1 Phosphatase1     VH53
Vaccinia Virus Homolog1     

External Ids:    HGNC: 30741   Entrez Gene: 18502   Ensembl: ENSG000001845457   OMIM: 6020385   UniProtKB: Q132023   

Export aliases for DUSP8 gene to outside databases

Previous GC identifers: GC11U990030 GC11M001539 GC11M001544 GC11M001533 GC11M001368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP8 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is
expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is
induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP8 Gene:
DUSP8 (dual specificity phosphatase 8) is a protein-coding gene. Diseases associated with DUSP8 include vaccinia. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
Function: This protein shows both activity toward tyrosine-protein phosphate as well as with
serine/threonine-protein phosphate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  NT_187584.1  NT_187657.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP8 gene promoter:
         COUP-TF1   USF1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   USF-1   c-Myb   Chx10   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DUSP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

DUSP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001531:  view genomic region     (about GC identifiers)

Start:
1,575,274 bp from pter      End:
1,593,150 bp from pter
Size:
17,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 8  
Size: 625 amino acids; 65827 Da
Secondary accessions: Q86SS8

Explore the universe of human proteins at neXtProt for DUSP8: NX_Q13202

Explore proteomics data for DUSP8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004411.2  
    ENSEMBL proteins: 
     ENSP00000380530   ENSP00000329539  

    DUSP8 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for DUSP8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q13202

    ProtoNet protein and cluster: Q13202

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS8_HUMAN, Q13202
    Function: This protein shows both activity toward tyrosine-protein phosphate as well as with
    serine/threonine-protein phosphate (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for DUSP8:
    dual specificity (tyr/thr) phosphatase 8,vaccinia virus VH1-like 5,murine M3/6 homolog,mainly expressed in
    brain,lung,tighty linked to H19 but not imprinted,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--
         
    Find genes that share ontologies with DUSP8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP8:
     Increased cell death HMECs cel  Increased circadian rhythm amp 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP8
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    miRNA
    Products:
        
    miRTarBase miRNAs that target DUSP8:
    hsa-mir-21-5p (MIRT030864), hsa-mir-186-5p (MIRT021135), hsa-mir-93-5p (MIRT028040), hsa-mir-130b-3p (MIRT020186), hsa-mir-320a (MIRT044453)

    Block miRNA regulation of human, mouse, rat DUSP8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP8 (see all 55):
    hsa-miR-411* hsa-miR-3678-3p hsa-miR-4291 hsa-miR-4317 hsa-miR-379* hsa-miR-4328 hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidDUSP8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DUSP8
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP8

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP8

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS8_HUMAN, Q13202: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with DUSP8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP8 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    2Regulation of p38-alpha and p38-beta
    Regulation of p38-alpha and p38-beta
    3ATF-2 transcription factor network
    ATF-2 transcription factor network


    Find genes that share SuperPaths with DUSP8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DUSP8
        Regulation of p38-alpha and p38-beta
    ATF-2 transcription factor network


    1 Kegg Pathway  (Kegg details for DUSP8):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DUSP8: 
              Protein Phosphatases in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DUSP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for DUSP8 (Q132022, 3 ENSP000003295394) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25AP303042, 3, ENSP000003037064MINT-8250767 I2D: score=2 STRING: ENSP00000303706
    MAPK8P459832, 3, ENSP000003534834MINT-8262297 I2D: score=2 STRING: ENSP00000353483
    MAPK11ENSP000003336854STRING: ENSP00000333685
    MAPK14ENSP000002297944STRING: ENSP00000229794
    MAPK1ENSP000002158324STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7561881

    Find genes that share ontologies with DUSP8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP8 (DUS8)

    3 HMDB Compounds for DUSP8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP8 gene: 
    NM_004420.2  

    Unigene Cluster for DUSP8:

    Dual specificity phosphatase 8
    Hs.41688  [show with all ESTs]
    Unigene Representative Sequence: NM_004420
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397374(uc001lts.2) ENST00000528778 ENST00000331588
    miRNA
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    Block miRNA regulation of human, mouse, rat DUSP8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP8 (see all 55):
    hsa-miR-411* hsa-miR-3678-3p hsa-miR-4291 hsa-miR-4317 hsa-miR-379* hsa-miR-4328 hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidDUSP8 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat DUSP8
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP8
      QuantiTect SYBR Green Assays in human, mouse, rat DUSP8
      QuantiFast Probe-based Assays in human, mouse, rat DUSP8

    Additional mRNA sequence: 

    AK124467.1 AK124948.1 BC038231.1 BC045110.1 U27193.1 

    5 DOTS entries:

    DT.409100  DT.91855692  DT.203539  DT.97798251  DT.100650571 

    Selected AceView cDNA sequences (see all 67):

    BM719419 BU956871 AA352007 AW341290 BC045110 BC038231 BU539157 BM684250 
    BU740880 AI248793 BM727409 AI799201 BX329356 BM908762 BX352800 BG056344 
    NM_004420 AI291001 BE791413 BE261477 N33504 BX283730 AK124948 BX098159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DUSP8 Expression
    About this image


    DUSP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    DUSP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.41688

    UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
    Tissue specificity: Abundant in brain, heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DUSP8: 
              Protein Phosphatases in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DUSP8
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP8
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    QuantiFast Probe-based Assays in human, mouse, rat DUSP8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp81 , 5 dual specificity phosphatase 81, 5 85.07(n)1
    90.23(a)1
      7 (87.59 cM)5
    182181  NM_008748.31  NP_032774.11 
     1420794905 
    chicken
    (Gallus gallus)
    Aves DUSP81 dual specificity phosphatase 8 72.09(n)
    71.87(a)
      770435  XM_001232892.2  XP_001232893.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP86
    dual specificity phosphatase 8
    64(a)
    1 ↔ 1
    1(70995116-71067675)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.182032 Transcribed sequence with weak similarity to protein more 75.52(n)    AL962948.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063941.12   -- 75.94(n)   393854  BC063941.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vhp-13   -- 44(a)   II(5331462-5340220)   --


    ENSEMBL Gene Tree for DUSP8 (if available)
    TreeFam Gene Tree for DUSP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP8 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP92  
    DUSP22  DUSP12  DUSP72  SSH12  
    11 SIMAP similar genes for DUSP8 using alignment to 1 protein entry:     DUS8_HUMAN:
    MKP7    DUSP22    STYX    DUSP16    DUSP21    DUSP18
    DUSP6    DUSP1    DUSP4    DUSP14    DUSP2

    Find genes that share paralogs with DUSP8           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for DUSP8 (see all 7)
    PGOHUM00000238464 PGOHUM00000238766 PGOHUM00000238770 PGOHUM00000238780 PGOHUM00000238841


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP8 (see all 344)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840915291,2
    --1574781(+) GTGAGC/TGGAGA 1 -- ds50010--------
    rs1891598951,2
    --1574789(+) AGATCA/GCACCA 1 -- ds50010--------
    rs1814964311,2
    --1574812(+) CTAGAC/TGACAG 1 -- ds50010--------
    rs1432962171,2
    --1574929(+) ACACAA/GCACAC 1 -- ds50010--------
    rs79518201,2
    C,F,H--1575068(+) ACAACC/TGAAAA 1 -- ds500128Minor allele frequency- T:0.28NS EA NA WA CSA 2708
    rs1141848071,2
    C,F--1575154(+) CACCCG/ACGGTG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1475490051,2
    --1575155(+) ACCCGC/TGGTGT 1 -- ds50010--------
    rs1874321201,2
    --1575270(+) GGCGCA/GGAGTC 1 -- ds50010--------
    rs1399692751,2
    C--1575373(+) AGGGG-/CTCCAA
            
    GGGGG
    1 -- cds10--------
    rs122845501,2
    A--1575607(+) CCTCCC/TGCAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP8 (1575274 - 1593150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DUSP8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7641CNV Insertion18451855
    dgv978n71CNV Loss21882294
    nsv896709CNV Loss21882294
    dgv968n71CNV Loss21882294
    dgv977n71CNV Loss21882294
    dgv973n71CNV Loss21882294
    nsv896708CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602038    OMIM disorders: --

    1 disease for DUSP8:    
    About MalaCards
    vaccinia


    Find genes that share disorders with DUSP8           About GenesLikeMe


    Export disorders for DUSP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP8 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DUSP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. (PubMed id 7561881)1, 2, 3 Martell K.J.... Dixon J.E. (J. Neurochem. 1995)
    2. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (PubMed id 9192849)1, 3, 9 Nesbit M.A....Davies K.E. (Genomics 1997)
    3. Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2. (PubMed id 15899389)1, 9 Berger I.R....Ullrich A. (Cancer Genet. Cytogenet. 2005)
    4. Investigation of DUSP8 and CALCA in alcohol dependence. (PubMed id 13129832)1, 9 Hink R.L....Sikela J.M. (Addict Biol 2003)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite. (PubMed id 22100391)1 Cotsiki M....Panayotou G. (Cell. Signal. 2012)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1850 HGNC: 3074 AceView: DUSP8 Ensembl:ENSG00000184545 euGenes: HUgn1850
    ECgene: DUSP8 Kegg: 1850 H-InvDB: DUSP8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP8 gene:
    Search GeneIP for patents involving DUSP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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