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Aliases for DUSP8 Gene

Aliases for DUSP8 Gene

  • Dual Specificity Phosphatase 8 2 3 5
  • Serine/Threonine Specific Protein Phosphatase 2 3
  • Dual Specificity Protein Phosphatase HVH-5 3 4
  • H1 Phosphatase, Vaccinia Virus Homolog 2 3
  • C11orf81 3 4
  • Dual Specificity Protein Phosphatase 8 3
  • Chromosome 11 Open Reading Frame 81 2
  • EC 4
  • EC 4
  • HVH-5 3
  • HVH8 3
  • HB5 3
  • VH5 4

External Ids for DUSP8 Gene

Previous HGNC Symbols for DUSP8 Gene

  • C11orf81

Previous GeneCards Identifiers for DUSP8 Gene

  • GC11U990030
  • GC11M001539
  • GC11M001544
  • GC11M001533
  • GC11M001368

Summaries for DUSP8 Gene

Entrez Gene Summary for DUSP8 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP8 Gene

DUSP8 (Dual Specificity Phosphatase 8) is a Protein Coding gene. Among its related pathways are RET signaling and RAF-independent MAPK1/3 activation. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP16.

UniProtKB/Swiss-Prot for DUSP8 Gene

  • Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.

Additional gene information for DUSP8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP8 Gene

Genomics for DUSP8 Gene

Regulatory Elements for DUSP8 Gene

Enhancers for DUSP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H001382 1.5 FANTOM5 Ensembl ENCODE 10.1 +189.6 189641 1.7 PKNOX1 KLF17 GLIS2 EGR1 ATF7 CREM EGR2 SP3 ZEB2 ZNF398 TOLLIP-AS1 TOLLIP MOB2 DUSP8 BRSK2 IFITM10 GC11M001373 GC11P001384
GH11H002139 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -573.3 -573309 13 ELF3 RB1 BATF RAD21 ZEB1 GLIS2 SCRT2 ZNF143 FOS RUNX3 TSSC4 ENSG00000199550 CD81 LSP1 LOC100505570 KRTAP5-6 FAM99B KRTAP5-5 IGF2 TH
GH11H001605 0.5 ENCODE 12.1 -33.3 -33258 0.8 NBN ELF1 MLLT1 ETV6 SPI1 KRTAP5-AS1 KRTAP5-5 KRTAP5-1 DUSP8 FAM99B LOC100505570 KRTAP5-6 KRTAP5-3 GC11P001598
GH11H001301 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +266.0 266016 10.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TOLLIP TSPAN4 MOB2 TMEM80 SNORA52 PHRF1 ENSG00000255237 PIDD1 CD151 BRSK2
GH11H001297 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +273.7 273729 3.9 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ATF7 SP5 ZHX2 MIER2 PIDD1 DRD4 TMEM80 GATD1 ENSG00000255142 ENSG00000255158 BRSK2 TOLLIP-AS1 TOLLIP DUSP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP8 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000262373 731 1801 PKNOX1 ATF1 SIN3A ZNF2 ZNF766 GLIS2 FOS ATF7 CREM SP3
ENSR00000035809 -1869 201 CTCF MXI1 ESRRA RB1 ZIC2 BCL11B RAD21 FOXM1 HIC1 GLIS2

Genomic Locations for DUSP8 Gene

Genomic Locations for DUSP8 Gene
18,788 bases
Minus strand

Genomic View for DUSP8 Gene

Genes around DUSP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP8 Gene

Proteins for DUSP8 Gene

  • Protein details for DUSP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 8
    Protein Accession:
    Secondary Accessions:
    • Q86SS8

    Protein attributes for DUSP8 Gene

    625 amino acids
    Molecular mass:
    65827 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DUSP8 Gene

neXtProt entry for DUSP8 Gene

Post-translational modifications for DUSP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP8 Gene

No data available for DME Specific Peptides for DUSP8 Gene

Domains & Families for DUSP8 Gene

Gene Families for DUSP8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP8: view

Function for DUSP8 Gene

Molecular function for DUSP8 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 8,vaccinia virus VH1-like 5,murine M3/6 homolog,mainly expressed in brain,lung,tighty linked to H19 but not imprinted,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.

Enzyme Numbers (IUBMB) for DUSP8 Gene

Phenotypes From GWAS Catalog for DUSP8 Gene

Gene Ontology (GO) - Molecular Function for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity ISS --
genes like me logo Genes that share ontologies with DUSP8: view
genes like me logo Genes that share phenotypes with DUSP8: view

Animal Models for DUSP8 Gene

MGI Knock Outs for DUSP8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP8 Gene

Localization for DUSP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP8 gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUSP8: view

Pathways & Interactions for DUSP8 Gene

SuperPathways for DUSP8 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Signaling by GPCR
genes like me logo Genes that share pathways with DUSP8: view

Pathways by source for DUSP8 Gene

SIGNOR curated interactions for DUSP8 Gene


Gene Ontology (GO) - Biological Process for DUSP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation ISS --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP8: view

Drugs & Compounds for DUSP8 Gene

(3) Drugs for DUSP8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(1) Additional Compounds for DUSP8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with DUSP8: view

Transcripts for DUSP8 Gene

Unigene Clusters for DUSP8 Gene

Dual specificity phosphatase 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP8 Gene

No ASD Table

Relevant External Links for DUSP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP8 Gene

This gene is overexpressed in Platelet (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP8 Gene

Protein tissue co-expression partners for DUSP8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP8 Gene:


SOURCE GeneReport for Unigene cluster for DUSP8 Gene:


mRNA Expression by UniProt/SwissProt for DUSP8 Gene:

Tissue specificity: Abundant in brain, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for DUSP8 Gene

  • Nervous system(4.4)
  • Skin(4)
genes like me logo Genes that share expression patterns with DUSP8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP8 Gene

Orthologs for DUSP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP8 34
  • 97 (a)
LOC746336 33
  • 96.46 (n)
(Ornithorhynchus anatinus)
Mammalia DUSP8 34
  • 95 (a)
(Canis familiaris)
Mammalia DUSP8 33 34
  • 87.8 (n)
(Mus musculus)
Mammalia Dusp8 33 16 34
  • 85.07 (n)
(Rattus norvegicus)
Mammalia Dusp8 33
  • 85.02 (n)
(Bos Taurus)
Mammalia DUSP8 34
  • 85 (a)
(Monodelphis domestica)
Mammalia DUSP8 34
  • 75 (a)
(Gallus gallus)
Aves DUSP8 33 34
  • 72.09 (n)
(Anolis carolinensis)
Reptilia DUSP8 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18203 33
(Danio rerio)
Actinopterygii dusp8a 33 34
  • 61.73 (n)
DUSP8 (2 of 2) 34
  • 47 (a)
-- 33
(Caenorhabditis elegans)
Secernentea vhp-1 35 34
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for DUSP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP8 Gene

Gene Tree for DUSP8 (if available)
Gene Tree for DUSP8 (if available)

Paralogs for DUSP8 Gene

Paralogs for DUSP8 Gene

(11) SIMAP similar genes for DUSP8 Gene using alignment to 1 proteins: Pseudogenes for DUSP8 Gene

genes like me logo Genes that share paralogs with DUSP8: view

Variants for DUSP8 Gene

Sequence variations from dbSNP and Humsavar for DUSP8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000029971 -- 1,572,792(+) CGCGA(A/C)CCCCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000102260 -- 1,565,528(+) CTGCC(C/T)GAGCT intron-variant
rs1000229116 -- 1,562,597(+) TACAC(A/G)TGCAC intron-variant
rs1000429271 -- 1,562,807(+) GGCCA(C/T)CCAGC intron-variant
rs1000548052 -- 1,557,114(+) CGACG(C/G)GCTGT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DUSP8 Gene

Variant ID Type Subtype PubMed ID
nsv7641 CNV insertion 18451855
nsv552996 CNV loss 21841781
nsv552989 CNV loss 21841781
nsv1112601 CNV deletion 24896259
nsv1112600 CNV deletion 24896259
nsv1069543 CNV deletion 25765185
dgv1553n54 CNV loss 21841781

Variation tolerance for DUSP8 Gene

Gene Damage Index Score: 1.06; 21.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP8 Gene

Disorders for DUSP8 Gene

Relevant External Links for DUSP8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUSP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP8 Gene

Publications for DUSP8 Gene

  1. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (PMID: 9192849) Nesbit MA … Davies KE (Genomics 1997) 2 3 22 60
  2. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. (PMID: 7561881) Martell KJ … Dixon JE (Journal of neurochemistry 1995) 2 3 4 60
  3. Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2. (PMID: 15899389) Berger IR … Ullrich A (Cancer genetics and cytogenetics 2005) 3 22 60
  4. Investigation of DUSP8 and CALCA in alcohol dependence. (PMID: 13129832) Hink RL … Sikela JM (Addiction biology 2003) 3 22 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DUSP8 Gene

Sources for DUSP8 Gene

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