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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP8 Gene

protein-coding   GIFtS: 57
GCID: GC11M001531

dual specificity phosphatase 8

(Previous name: chromosome 11 open reading frame 81 )
(Previous symbol: C11orf81)
 Explore 4 diseases affiliated with
DUSP8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DUSP8    

Aliases
for DUSP8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dual Specificity Phosphatase 81 2     Chromosome 11 Open Reading Frame 811
C11orf811 2 3     Dual Specificity Protein Phosphatase 82
HB51 2     H1 Phosphatase, Vaccinia Virus Homolog2
HVH-51 2     Serine/Threonine Specific Protein Phosphatase2
Dual Specificity Protein Phosphatase HVH-52 3     EC 3.1.3.163
HVH82 5     EC 3.1.3.483
FLJ429581     VH53

External Ids:    HGNC: 30741   Entrez Gene: 18502   Ensembl: ENSG000001845457   OMIM: 6020385   UniProtKB: Q132023   

Export aliases for DUSP8 gene to outside databases

Previous GC identifers: GC11U990030 GC11M001539 GC11M001544 GC11M001533 GC11M001368


Summaries
for DUSP8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUSP8:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.
They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),
which is associated with cellular proliferation and differentiation. Different members of the family of dual
specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution
and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This
gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle,
is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8
is present on chromosome 10q11.2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
Function: This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein
phosphate (By similarity)




Genomic Views
for DUSP8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP8 gene promoter:
         COUP-TF1   USF1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   USF-1   c-Myb   Chx10   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DUSP8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

DUSP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001531:  view genomic region     (about GC identifiers)

Start:
 1,575,274 bp from pter      End:
 1,593,150 bp from pter
Size:
 17,877 bases      Orientation:
 minus strand

Proteins
for DUSP8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 8  
Size: 625 amino acids; 65827 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q86SS8

Explore the universe of human proteins at neXtProt for DUSP8: NX_Q13202

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13202

    • DUSP8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004411.2  
    ENSEMBL proteins: 
     ENSP00000380530   ENSP00000329539  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: DUSP8
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    Novus Biologicals DUSP8 Protein
    Novus Biologicals DUSP8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DUSP8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--


    DUSP8 for ontologies           About GeneDecksing



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    Uscn Antibodies for DUSP8
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    Uscn ELISAs and CLIAs for DUSP8

    Protein Domains /
    Families
    for DUSP8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DUSP8 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q13202

    ProtoNet protein and cluster: Q13202

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for DUSP8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
    Function: This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein
    phosphate (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP8:
    dual specificity (tyr/thr) phosphatase 8,vaccinia virus VH1-like 5,murine M3/6 homolog,mainly expressed in
    brain,lung,tighty linked to H19 but not imprinted,involved in signal transduction

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP8
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP8 (see all 55):
    hsa-miR-411* hsa-miR-3678-3p hsa-miR-4291 hsa-miR-4317 hsa-miR-379* hsa-miR-4328 hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP8 (see all 7)
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--


    DUSP8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DUSP8:
     Increased cell death HMECs cel  Increased circadian rhythm amp 


    Pathways & Interactions
    for DUSP8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ATF-2 transcription factor network
    		ATF-2 transcription factor network1.00
    2Regulation of p38-alpha and p38-beta
    		Regulation of p38-alpha and p38-beta1.00
    3MAPK signaling pathway
    		MAPK signaling pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for DUSP8 
        ATF-2 transcription factor network
    Regulation of p38-alpha and p38-beta


    1         Kegg Pathway  (Kegg details for DUSP8):
        MAPK signaling pathway


    DUSP8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for DUSP8 (Q132022, 3 ENSP000003295394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25AP303042, 3, ENSP000003037064MINT-8250767 I2D: score=2 STRING: ENSP00000303706
    MAPK8P459832, 3, ENSP000003534834MINT-8262297 I2D: score=2 STRING: ENSP00000353483
    MAPK11ENSP000003336854STRING: ENSP00000333685
    MAPK14ENSP000002297944STRING: ENSP00000229794
    MAPK1ENSP000002158324STRING: ENSP00000215832
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7561881


    DUSP8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUSP8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP8

    3 HMDB Compounds for DUSP8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about DUSP8 / DUS8 

    Transcripts
    for DUSP8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUSP8 gene: 
    NM_004420.2  

    Unigene Cluster for DUSP8:

    Dual specificity phosphatase 8
    Hs.41688  [show with all ESTs]
    Unigene Representative Sequence: NM_004420
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397374(uc001lts.2) ENST00000528778 ENST00000331588

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP8 (see all 55):
    hsa-miR-411* hsa-miR-3678-3p hsa-miR-4291 hsa-miR-4317 hsa-miR-379* hsa-miR-4328 hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP8 (see all 7)
    OriGene shRNA RFP: DUSP8
    OriGene siRNA: DUSP8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP8
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP8

    Additional cDNA sequence: 

    AK124467.1 AK124948.1 BC038231.1 BC045110.1 U27193.1 

    5 DOTS entries:

    DT.409100  DT.91855692  DT.203539  DT.97798251  DT.100650571 

    24/67 AceView cDNA sequences (see all 67):

    AI248793 BM719419 BM727409 BU539157 AW341290 AA352007 BU956871 BU740880 
    BC045110 BC038231 BM684250 AI799201 CB160507 BM908762 BE261477 N33504 
    BG519627 AI554954 AK124467 NM_004420 BG056344 BM563030 AK124948 BF590641 

    GeneLoc Exon Structure


    Expression
    for DUSP8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DUSP8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DUSP8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP8

    SOURCE GeneReport for Unigene cluster: Hs.41688

    UniProtKB/Swiss-Prot: DUS8_HUMAN, Q13202
    Tissue specificity: Abundant in brain, heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP8: 
              Protein Phosphatases in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for DUSP8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP8 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DUSP81 dual specificity phosphatase 8 72.87(n)
    72.65(a)    		   770435  XM_001232892.1  XP_001232893.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DUSP86
    		 --
    		 63(a)
    		 1 ↔ 1
    		 1(70995282-71067675)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.182032 Transcribed sequence with weak similarity to protein more 75.52(n)    AL962948.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC063941.12   -- 75.94(n)   393854  BC063941.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea vhp-11 , 3 Protein VHP-11 44(a)3
    41.87(n)1
    39.55(a)1    		   II(5331462-5340220)3
    1739041  NM_062596.31  NP_494997.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DSPTP1E6
    		 protein-tyrosine-phosphatase IBR5
    		 20(a)
    		 possible ortholog
    		 2(1588360-1590166)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 dual specificity protein phosphatase, putative, ex...
    dual specificity protein phosphatase, putative, ex...
    		 18(a)
    17(a)
    		 possible ortholog
    possible ortholog
    		 2(29876197-29879380)
    6(11683181-11686916)


    ENSEMBL Gene Tree for DUSP8 (if available)
    TreeFam Gene Tree for DUSP8 (if available) 

    Paralogs
    for DUSP8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP8 gene
    DUSP212  DUSP42  SSH22  DUSP102  DUSP62  DUSP192  DUSP142  DUSP282  
    DUSP72  DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  
    DUSP12  
    12 SIMAP similar genes for DUSP8 using alignment to 1 protein entry:     DUS8_HUMAN:
    MKP7    DUSP22    STYX    DUSP16    DUSP21    DUSP18
    DUSP6    DUSP1    DUSP4    DUSP14    DUSP2    DUSP9

    DUSP8 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for DUSP8 (see all 7)
    PGOHUM00000238464 PGOHUM00000238766 PGOHUM00000238770 PGOHUM00000238780 PGOHUM00000238841


    Genomic Variants
    for DUSP8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/295 NCBI SNPs in DUSP8 are shown (see all 295)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1840915291,2
    		--1574781(+) GTGAGC/TGGAGA 1 -- ds50010--------
    rs1891598951,2
    		--1574789(+) AGATCA/GCACCA 1 -- ds50010--------
    rs1814964311,2
    		--1574812(+) CTAGAC/TGACAG 1 -- ds50010--------
    rs1432962171,2
    		--1574929(+) ACACAA/GCACAC 1 -- ds50010--------
    rs79518201,2
    		C,F,H,--1575068(+) ACAACC/TGAAAA 1 -- ds500128Minor allele frequency- T:0.28NS EA NA WA CSA 2708
    rs1141848071,2
    		F,--1575154(+) CACCCG/ACGGTG 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1475490051,2
    		--1575155(+) ACCCGC/TGGTGT 1 -- ds50010--------
    rs1874321201,2
    		--1575270(+) GGCGCA/GGAGTC 1 -- ds50010--------
    rs1399692751,2
    		C,--1575373(+) AGGGG-/CTCCAA
                GGGGG     		1 -- ut310--------
    rs122845501,2
    		A--1575607(+) CCTCCC/TGCAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP8 (1575274 - 1593150 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DUSP8
         1 CNV: 34933

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    Disorders / Diseases
    for DUSP8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUSP8 for disorders           About GeneDecksing

    OMIM gene information: 602038    OMIM disorders: --

    4 diseases for DUSP8:    About MalaCards
    vaccinia    alcohol dependence    alcoholism    gastric cancer


    Export disorders for DUSP8 gene to outside databases

    Publications
    for DUSP8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP8 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DUSP8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. (PubMed id 7561881)1, 2, 3 Martell K.J.... Dixon J.E. (1995)
    2. Genomic organization and chromosomal localization of a member of the MAP kinase phosphatase gene family to human chromosome 11p15.5 and a pseudogene to 10q11.2. (PubMed id 9192849)1, 3, 9 Nesbit M.A....Davies K.E. (1997)
    3. Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2. (PubMed id 15899389)1, 9 Berger I.R....Ullrich A. (2005)
    4. Investigation of DUSP8 and CALCA in alcohol dependence. (PubMed id 13129832)1, 9 Hink R.L....Sikela J.M. (2003)
    5. Phosphorylation of the M3/6 dual-specificity phosphata se enhances the activation of JNK by arsenite. (PubMed id 22100391)1 Cotsiki M....Panayotou G. (2012)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    External Searches for DUSP8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing DUSP8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1850 HGNC: 3074 AceView: DUSP8 Ensembl:ENSG00000184545 euGenes: HUgn1850
    ECgene: DUSP8 Kegg: 1850 H-InvDB: DUSP8

    Other Databases showing DUSP8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUSP8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP8 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DUSP8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUSP8 gene:
    Search GeneIP for patents involving DUSP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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