Aliases for DUSP8 Gene
External Ids for DUSP8 Gene
Previous HGNC Symbols for DUSP8 Gene
Previous GeneCards Identifiers for DUSP8 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP8 Gene
DUSP8 (Dual Specificity Phosphatase 8) is a Protein Coding gene. Diseases associated with DUSP8 include vaccinia and alcohol dependence. Among its related pathways are MAPK signaling pathway and Regulation of p38-alpha and p38-beta. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot for DUSP8 Gene
This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.