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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DUSP7 Gene

protein-coding GIFtS: 64
GCID: GC03M052082

dual specificity phosphatase 7

Explore 3 diseases affiliated with
DUSP7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 7¹ ²		Dual Specificity Protein Phosphatase 7²
PYST2¹ ² ³ ⁵		Dual-Specificity Phosphatase-7²
Dual Specificity Protein Phosphatase PYST2² ³		EC 3.1.3.16³
MKPX² ⁵		EC 3.1.3.48³
MKP-X¹

External Ids:	HGNC: 3073¹	Entrez Gene: 1849²	Ensembl: ENSG00000164086⁷	OMIM: 602749⁵	UniProtKB: Q16829³

Export aliases for DUSP7 gene to outside databases

Previous GC identifers: GC03M051176 GC03M051336 GC03M051940 GC03M052042 GC03M052059

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP7:

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based

protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine

and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK

(mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with

specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain

and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic

processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et

al., 2009 (PubMed 19228121)).(supplied by OMIM, Dec 2009)

UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829

Function: Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S

may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription,

translation or activation factors

Gene Wiki entry for DUSP7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DUSP7 gene promoter:
HOXA9B HOXA9 Nkx2-2 MyoD AP-2gamma Meis-1b AP-2beta AP-2alpha Meis-1 AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DUSP7 promoter sequence

Search SABiosciences Chromatin IP Primers for DUSP7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21

DUSP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP7 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M052082: view genomic region (about GC identifiers)

Start:	52,082,935 bp from pter	End:	52,090,566 bp from pter
Size:	7,632 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829 (See protein sequence)

Recommended Name: Dual specificity protein phosphatase 7

Size: 419 amino acids; 44957 Da

Subcellular location: Cytoplasm

Caution: An out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the

alternative promoter. The expression of the in-frame product has not yet been shown

Secondary accessions: Q2M3J7 Q8NFJ0

Alternative promoter usage: 2 isoforms: Q16829-1 Q16829-2

Explore the universe of human proteins at neXtProt for DUSP7: NX_Q16829

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16829

DUSP7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001938.2

ENSEMBL proteins:

ENSP00000417183 ENSP00000418566 ENSP00000296483

Reactome Protein details: Q16829
Human Recombinant Protein Products for DUSP7:

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	Uscn Proteins for DUSP7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	IDA	9788880

DUSP7 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DUSP7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DUSP7 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001763 Rhodanese-like_dom

IPR000387 Tyr/Dual-sp_Pase

IPR020422 Dual-sp_phosphatase_subgr_cat

IPR024950 DUSP

IPR000340 Dual-sp_phosphatase_cat-dom

Graphical View of Domain Structure for InterPro Entry Q16829

ProtoNet protein and cluster: Q16829

2 Blocks protein families:

IPB000340 Dual specificity protein phosphatase

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily

Similarity: Contains 1 rhodanese domain

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DUS7_HUMAN, Q16829

Function: Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S

may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription,

translation or activation factors

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Genatlas biochemistry entry for DUSP7:

dual specificity (tyr/thr) phosphatase 7,involved in signal transduction

Enzyme Numbers (IUBMB): EC 3.1.3.16¹ EC 3.1.3.48¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IEA	--
GO:0005515	protein binding	IPI	12907755
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	IDA	9788880

DUSP7 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for DUSP7:

Altered focal adhesion (FA) or

Decreased TP53 protein express

Increased Akt phosphorylation

Increased apoptosis

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DUSP7

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		hsa-miR-548j hsa-miR-132* hsa-miR-193a-3p hsa-miR-1321 hsa-miR-200a hsa-miR-548a-5p hsa-miR-200b hsa-miR-4293

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

ERK/MAPK targets

	ERK/MAPK targets	1.00			MAPK targets/ Nuclear events mediated by MAP kinases	0.70
	Nuclear Events (kinase and transcription factor activation)	0.88			ERKs are inactivated	0.57

Immune System

Immune System

1.00

Innate Immune System

0.46

Signal transduction Erk Interactions: Inhibition of Erk

Signal transduction Erk Interactions: Inhibition of Erk

1.00

Signal transduction_Erk Interactions- Inhibition of Erk

0.92

MAPK signaling pathway

MAPK signaling pathway

1.00

MAPK signaling pathway

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for DUSP7

Signal transduction Erk Interactions- Inhibition of Erk

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP7

JNK Pathway

1 GeneGo (Thomson Reuters) Pathway for DUSP7

Signal transduction Erk Interactions- Inhibition of Erk

1 BioSystems Pathway for DUSP7

MAPK signaling pathway

5/28 Reactome Pathways for DUSP7 (see all 28)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	TRAF6 Mediated Induction of proinflammatory cytokines
	Toll Like Receptor 7/8 (TLR7/8) Cascade

1 Kegg Pathway (Kegg details for DUSP7):

MAPK signaling pathway

DUSP7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DUSP7

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for DUSP7 (Q16829^{1, 2, 3} ENSP00000296483⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GHR	P10912¹^,²^,³, ENSP00000230882⁴	EBI-1265847,EBI-286316 MINT-6797534 I2D: score=3 STRING: ENSP00000230882
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-8209385 MINT-8209376 I2D: score=4 STRING: ENSP00000215832
EEF1A1	P68104²^,³, ENSP00000330054⁴	MINT-8254811 I2D: score=2 STRING: ENSP00000330054
MAPK14	Q16539²^,³, ENSP00000229794⁴	MINT-8209366 MINT-8209356 I2D: score=3 STRING: ENSP00000229794
MAPK8	P45983³, ENSP00000353483⁴	I2D: score=2 STRING: ENSP00000353483

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	IBA	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--
GO:0006470	protein dephosphorylation	--	--

DUSP7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUSP7

3 HMDB Compounds for DUSP7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about DUSP7 / DUS7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUSP7 gene:

NM_001947.3

Unigene Cluster for DUSP7:

Dual specificity phosphatase 7

Hs.591664 [show with all ESTs]

Unigene Representative Sequence: NM_001947

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000495880(uc003dct.3) ENST00000469623(uc010hma.2) ENST00000296483

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		hsa-miR-548j hsa-miR-132* hsa-miR-193a-3p hsa-miR-1321 hsa-miR-200a hsa-miR-548a-5p hsa-miR-200b hsa-miR-4293

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Additional cDNA sequence:

AF508727.1 AF508728.1 AL110157.1 BC019107.2 BC104880.1 BC104882.1 BC128064.1 X93921.1

4 DOTS entries:

DT.409384 DT.75101263 DT.95159801 DT.95367075

24/70 AceView cDNA sequences (see all 70):

BU753703 AI202182 AW953476 AI681665 F08899 BX279928 BC019107 BU178722

BM772606 N52350 AW631273 AA782293 BX111704 AF508728 AI362689 NM_001947

BQ024545 AF508727 AI681699 AL110157 AW083474 T09370 AW518795 AI424972

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUSP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCTCTTTT

About this image

DUSP7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DUSP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP7

SOURCE GeneReport for Unigene cluster: Hs.591664

UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829

Tissue specificity: Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding

non-malignant cells

SABiosciences Expression via Pathway-Focused PCR Array including DUSP7:

Protein Phosphatases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP7 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DUSP7⁶	Uncharacterized protein	92(a)	1 ↔ 1	12(199683-202455)
lizard (Anolis carolinensis)	Reptilia	DUSP7⁶	--	81(a)	1 ↔ 1	2(153857327-153867140)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.14313²	Transcribed sequence with weak similarity to protein more	75.18(n)		137716477
zebrafish (Danio rerio)	Actinopterygii	dusp7¹	dual specificity phosphatase 7	81.14(n) 85.99(a)		327246 NM_199774.2 NP_956068.2
fruit fly (Drosophila melanogaster)	Insecta	Mkp3^{1 , 3}	protein amino acid dephosphorylation protein tyrosine/serine/threonine more³ Mitogen-activated protein kinase phosphatase 3¹	42(a)³ 52.81(n)¹ 44.88(a)¹		75F6³ 40081¹ NM_140830.1¹ NP_649087.1¹
worm (Caenorhabditis elegans)	Secernentea	lip-1^{1 , 3}	protein-tyrosine phosphatase³ Protein LIP-1¹	53(a)³ 45.28(n)¹ 39.25(a)¹		IV(6843152-6845014)³ 191704¹ NM_068652.2¹ NP_501053.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	DSPTP1E⁶	protein-tyrosine-phosphatase IBR5	20(a)	possible ortholog	2(1588360-1590166)
rice (Oryza sativa)	Liliopsida	-- --	dual specificity protein phosphatase, putative, ex... dual specificity protein phosphatase, putative, ex...	16(a) 16(a)	possible ortholog possible ortholog	2(29876197-29879380) 6(11683181-11686916)

ENSEMBL Gene Tree for DUSP7 (if available)
TreeFam Gene Tree for DUSP7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DUSP7 gene

DUSP4² DUSP21² SSH2² DUSP10² DUSP6² DUSP19² DUSP14² DUSP28²

DUSP8² DUSP5² SSH3² DUSP16² DUSP9² DUSP2² DUSP18² SSH1²

DUSP1²

12 SIMAP similar genes for DUSP7 using alignment to 2 protein entries: DUS7_HUMAN (see all proteins):

DUSP6 DUSP9 DUSP19 DUSP22 DUSP14 DUSP3

DUSP1 DUSP21 DUSP4 DUSP18 DUSP2 DUSP5

DUSP7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148304002^1,2		--	52082538(+)	`ACCCAA/CACGGC`	1	--	int¹		0	--	--	--	--
rs143071238^1,2		--	52082588(+)	`GGCAAC/TGCCTA`	1	--	int¹		0	--	--	--	--
rs188428038^1,2		--	52082605(+)	`CAGCCG/TCAGAC`	1	--	int¹		0	--	--	--	--
rs193188004^1,2		--	52082929(+)	`GACACA/GACTCA`	1	--	int¹		0	--	--	--	--
rs138760384^1,2		--	52082994(+)	`TCGGG-/ATATATA`	1	--	ut3¹		0	--	--	--	--
rs185464933^1,2		--	52083091(+)	`CATACC/TCTCAT`	1	--	ut3¹		0	--	--	--	--
rs189246237^1,2		--	52083159(+)	`AGAGAA/GCCATG`	1	--	ut3¹		0	--	--	--	--
rs147485394^1,2		--	52083497(+)	`TGCCCC/TACTTG`	1	--	ut3¹		0	--	--	--	--
rs74328888^1,2		--	52083651(+)	`AGGTCG/AGGCTG`	1	--	ut3¹		1		EA	120
rs116661152^1,2	F	--	52083686(+)	`AGCCAC/GTGGGC`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for DUSP7 (52082935 - 52090566 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DUSP7
2 CNVs: 68375 51113

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DUSP7 for disorders           About GeneDecksing

OMIM gene information: 602749    OMIM disorders: --

3 diseases for DUSP7:    About MalaCards

myeloid leukemia acute leukemia leukemia

Export disorders for DUSP7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DUSP7 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with DUSP7)

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Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)^{1, 3, 9} Smith A....Ashworth A. (1997)
Characterization of the dual-specificity phosphatase PYST2 and its transcripts. (PubMed id 14603440)^{1, 2} Levy-Nissenbaum O.... Witz I.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. (PubMed id 14576828)^{1, 2} Levy-Nissenbaum O.... Witz I.P. (2003)
MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PubMed id 8626780)^{1, 3} Muda M....Arkinstall S. (1996)
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. (PubMed id 8670865)^{1, 2} Groom L.A.... Keyse S.M. (1996)
Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. (PubMed id 9788880)^{1, 9} Dowd S....Keyse S.M. (1998)
cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. (PubMed id 14674243)^{1, 9} Levy-Nissenbaum O....Witz I.P. (2003)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1849	HGNC: 3073	AceView: DUSP7	Ensembl:ENSG00000164086	euGenes: HUgn1849
ECgene: DUSP7	Kegg: 1849	H-InvDB: DUSP7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DUSP7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DUSP7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DUSP7 gene
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Patent Information for DUSP7 gene:
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