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Aliases for DUSP7 Gene

Aliases for DUSP7 Gene

  • Dual Specificity Phosphatase 7 2 3 5
  • Dual Specificity Protein Phosphatase PYST2 3 4
  • PYST2 3 4
  • Dual Specificity Protein Phosphatase 7 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • MKPX 3

External Ids for DUSP7 Gene

Previous GeneCards Identifiers for DUSP7 Gene

  • GC03M051176
  • GC03M051336
  • GC03M051940
  • GC03M052042
  • GC03M052059

Summaries for DUSP7 Gene

Entrez Gene Summary for DUSP7 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP7 Gene

DUSP7 (Dual Specificity Phosphatase 7) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and MAPK targets/ Nuclear events mediated by MAP kinases. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP6.

UniProtKB/Swiss-Prot for DUSP7 Gene

  • Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.

Gene Wiki entry for DUSP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP7 Gene

Genomics for DUSP7 Gene

Regulatory Elements for DUSP7 Gene

Enhancers for DUSP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DUSP7 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP7 Gene

Chromosome:
3
Start:
52,048,919 bp from pter
End:
52,056,550 bp from pter
Size:
7,632 bases
Orientation:
Minus strand

Genomic View for DUSP7 Gene

Genes around DUSP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP7 Gene

Proteins for DUSP7 Gene

  • Protein details for DUSP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16829-DUS7_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 7
    Protein Accession:
    Q16829
    Secondary Accessions:
    • Q2M3J7
    • Q8NFJ0

    Protein attributes for DUSP7 Gene

    Size:
    419 amino acids
    Molecular mass:
    44957 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP7 Gene

    Alternative splice isoforms for DUSP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP7 Gene

Post-translational modifications for DUSP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP7 Gene

Domains & Families for DUSP7 Gene

Gene Families for DUSP7 Gene

Suggested Antigen Peptide Sequences for DUSP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16829

UniProtKB/Swiss-Prot:

DUS7_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP7: view

Function for DUSP7 Gene

Molecular function for DUSP7 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 7,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.

Enzyme Numbers (IUBMB) for DUSP7 Gene

Gene Ontology (GO) - Molecular Function for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity TAS --
GO:0005515 protein binding IPI 12907755
GO:0008138 protein tyrosine/serine/threonine phosphatase activity TAS --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IDA 9788880
genes like me logo Genes that share ontologies with DUSP7: view
genes like me logo Genes that share phenotypes with DUSP7: view

Animal Models for DUSP7 Gene

MGI Knock Outs for DUSP7:

Animal Model Products

CRISPR Products

miRNA for DUSP7 Gene

miRTarBase miRNAs that target DUSP7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP7

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP7 Gene

Localization for DUSP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP7 Gene COMPARTMENTS Subcellular localization image for DUSP7 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DUSP7: view

Pathways & Interactions for DUSP7 Gene

SuperPathways for DUSP7 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 MyD88 cascade initiated on plasma membrane
3 MAPK targets/ Nuclear events mediated by MAP kinases
4 MAPK signaling pathway
5 Developmental Biology
genes like me logo Genes that share pathways with DUSP7: view

Pathways by source for DUSP7 Gene

1 BioSystems pathway for DUSP7 Gene
1 KEGG pathway for DUSP7 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP7 Gene
1 Qiagen pathway for DUSP7 Gene

SIGNOR curated interactions for DUSP7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IDA 9788880
GO:0043407 negative regulation of MAP kinase activity IDA 9788880
genes like me logo Genes that share ontologies with DUSP7: view

Drugs & Compounds for DUSP7 Gene

(3) Drugs for DUSP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(1) Additional Compounds for DUSP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP7: view

Transcripts for DUSP7 Gene

mRNA/cDNA for DUSP7 Gene

Unigene Clusters for DUSP7 Gene

Dual specificity phosphatase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP7 Gene

No ASD Table

Relevant External Links for DUSP7 Gene

GeneLoc Exon Structure for
DUSP7
ECgene alternative splicing isoforms for
DUSP7

Expression for DUSP7 Gene

mRNA expression in normal human tissues for DUSP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP7 Gene

This gene is overexpressed in Platelet (31.3), Adipocyte (24.7), and Peripheral blood mononuclear cells (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP7 Gene



Protein tissue co-expression partners for DUSP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP7 Gene:

DUSP7

SOURCE GeneReport for Unigene cluster for DUSP7 Gene:

Hs.591664

mRNA Expression by UniProt/SwissProt for DUSP7 Gene:

Q16829-DUS7_HUMAN
Tissue specificity: Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
genes like me logo Genes that share expression patterns with DUSP7: view

Primer Products

No data available for mRNA differential expression in normal tissues for DUSP7 Gene

Orthologs for DUSP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP7 34
  • 93.32 (n)
  • 97.85 (a)
DUSP7 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP7 34
  • 93.4 (n)
  • 97.61 (a)
DUSP7 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp7 34
  • 92.44 (n)
  • 97.85 (a)
Dusp7 16
Dusp7 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP7 34
  • 96.53 (n)
  • 96.16 (a)
DUSP7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp7 34
  • 91.73 (n)
  • 98.09 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP7 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP7 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP7 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP7 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp7 34
  • 73.15 (n)
  • 78.63 (a)
Str.14313 34
zebrafish
(Danio rerio)
Actinopterygii dusp7 34
  • 80.22 (n)
  • 84.89 (a)
dusp7 35
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 36
  • 42 (a)
Mkp3 34
  • 52.91 (n)
  • 44.88 (a)
Mkp3 35
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012237 34
  • 54.85 (n)
  • 46.52 (a)
worm
(Caenorhabditis elegans)
Secernentea lip-1 36
  • 53 (a)
lip-1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 35
  • 39 (a)
OneToMany
Species where no ortholog for DUSP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP7 Gene

ENSEMBL:
Gene Tree for DUSP7 (if available)
TreeFam:
Gene Tree for DUSP7 (if available)

Paralogs for DUSP7 Gene

Paralogs for DUSP7 Gene

(12) SIMAP similar genes for DUSP7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP7: view

Variants for DUSP7 Gene

Sequence variations from dbSNP and Humsavar for DUSP7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs34821455 - 52,054,188(+) CAGGG(C/T)TGCCG reference, missense
rs4687607 -- 52,054,635(+) ACTTC(A/G)GGGCC intron-variant
rs9851576 -- 52,057,238(+) ATCCT(A/G)GAAAG upstream-variant-2KB
rs76950732 -- 52,051,778(+) CTGCA(C/T)TTCGC intron-variant
rs77231322 -- 52,053,687(+) GCAGA(C/G)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP7 Gene

Variant ID Type Subtype PubMed ID
dgv8323n54 CNV loss 21841781
dgv8324n54 CNV gain 21841781
dgv8325n54 CNV loss 21841781
esv25634 CNV loss 19812545
nsv1003453 CNV gain 25217958
nsv1072692 CNV deletion 25765185
nsv1136363 CNV deletion 24896259
nsv508923 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv520211 CNV gain 19592680
nsv590281 CNV loss 21841781
nsv590282 CNV gain 21841781
nsv590289 CNV gain+loss 21841781
nsv590296 CNV gain 21841781
nsv954857 CNV deletion 24416366

Variation tolerance for DUSP7 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP7 Gene

Disorders for DUSP7 Gene

Relevant External Links for DUSP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP7

No disorders were found for DUSP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP7 Gene

Publications for DUSP7 Gene

  1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A. … Ashworth A. (Genomics 1997) 2 3 22 65
  2. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. (PMID: 14603440) Levy-Nissenbaum O. … Witz I.P. (Genes Chromosomes Cancer 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. (PMID: 14576828) Levy-Nissenbaum O. … Witz I.P. (Oncogene 2003) 3 4 65
  5. cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. (PMID: 14674243) Levy-Nissenbaum O. … Witz I.P. (Meth. Enzymol. 2003) 3 22 65

Products for DUSP7 Gene

Sources for DUSP7 Gene

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