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Aliases for DUSP7 Gene

Aliases for DUSP7 Gene

  • Dual Specificity Phosphatase 7 2 3
  • PYST2 3 4 6
  • Dual Specificity Protein Phosphatase PYST2 3 4
  • MKPX 3 6
  • Dual Specificity Protein Phosphatase 7 3
  • Dual-Specificity Phosphatase-7 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP7 Gene

Summaries for DUSP7 Gene

Entrez Gene Summary for DUSP7 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP7 Gene

DUSP7 (Dual Specificity Phosphatase 7) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP7 Gene

  • Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.

Gene Wiki entry for DUSP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP7 Gene

Genomics for DUSP7 Gene

Genomic Location for DUSP7 Gene

Start:
52,048,919 bp from pter
End:
52,056,550 bp from pter
Size:
7,632 bases
Orientation:
Minus strand

Genomic View for DUSP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP7 Gene

Regulatory Elements for DUSP7 Gene

Proteins for DUSP7 Gene

  • Protein details for DUSP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16829-DUS7_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 7
    Protein Accession:
    Q16829
    Secondary Accessions:
    • Q2M3J7
    • Q8NFJ0

    Protein attributes for DUSP7 Gene

    Size:
    419 amino acids
    Molecular mass:
    44957 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DUSP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP7 Gene

Proteomics data for DUSP7 Gene at MOPED

Post-translational modifications for DUSP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP7 Gene

Domains for DUSP7 Gene

Gene Families for DUSP7 Gene

HGNC:
  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

UniProtKB/Swiss-Prot:

DUS7_HUMAN
Domain:
  • Contains 1 rhodanese domain.:
    • Q16829
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q16829
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • Q16829
genes like me logo Genes that share domains with DUSP7: view

Function for DUSP7 Gene

Molecular function for DUSP7 Gene

GENATLAS Biochemistry: dual specificity (tyr/thr) phosphatase 7,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.

Enzyme Numbers (IUBMB) for DUSP7 Gene

Gene Ontology (GO) - Molecular Function for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 12907755
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
GO:0016791 phosphatase activity --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IDA 9788880
genes like me logo Genes that share ontologies with DUSP7: view
genes like me logo Genes that share phenotypes with DUSP7: view

miRNA for DUSP7 Gene

miRTarBase miRNAs that target DUSP7

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP7 Gene

Localization for DUSP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP7 Gene COMPARTMENTS Subcellular localization image for DUSP7 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA 9788880
genes like me logo Genes that share ontologies with DUSP7: view

Pathways for DUSP7 Gene

genes like me logo Genes that share pathways with DUSP7: view

Pathways by source for DUSP7 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for DUSP7 Gene
1 Qiagen pathway for DUSP7 Gene
1 BioSystems pathway for DUSP7 Gene

Gene Ontology (GO) - Biological Process for DUSP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006470 protein dephosphorylation --
genes like me logo Genes that share ontologies with DUSP7: view

Compounds for DUSP7 Gene

(3) HMDB Compounds for DUSP7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with DUSP7: view

Transcripts for DUSP7 Gene

mRNA/cDNA for DUSP7 Gene

Unigene Clusters for DUSP7 Gene

Dual specificity phosphatase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP7 Gene

No ASD Table

Relevant External Links for DUSP7 Gene

GeneLoc Exon Structure for
DUSP7
ECgene alternative splicing isoforms for
DUSP7

Expression for DUSP7 Gene

mRNA expression in normal human tissues for DUSP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP7 Gene

SOURCE GeneReport for Unigene cluster for DUSP7 Gene Hs.591664

mRNA Expression by UniProt/SwissProt for DUSP7 Gene

Q16829-DUS7_HUMAN
Tissue specificity: Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.
genes like me logo Genes that share expressions with DUSP7: view

Orthologs for DUSP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP7 36
  • 96.53 (n)
  • 96.16 (a)
DUSP7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP7 36
  • 93.32 (n)
  • 97.85 (a)
DUSP7 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP7 36
  • 93.4 (n)
  • 97.61 (a)
DUSP7 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp7 36
  • 92.44 (n)
  • 97.85 (a)
Dusp7 16
Dusp7 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP7 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP7 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp7 36
  • 91.73 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves DUSP7 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP7 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp7 36
  • 73.15 (n)
  • 78.63 (a)
Str.14313 36
zebrafish
(Danio rerio)
Actinopterygii dusp7 36
  • 80.22 (n)
  • 84.89 (a)
dusp7 37
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012237 36
  • 54.85 (n)
  • 46.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 36
  • 52.91 (n)
  • 44.88 (a)
Mkp3 37
  • 38 (a)
OneToMany
Mkp3 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea lip-1 37
  • 29 (a)
OneToMany
lip-1 38
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 37
  • 39 (a)
OneToMany
Species with no ortholog for DUSP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP7 Gene

ENSEMBL:
Gene Tree for DUSP7 (if available)
TreeFam:
Gene Tree for DUSP7 (if available)

Paralogs for DUSP7 Gene

Paralogs for DUSP7 Gene

Selected SIMAP similar genes for DUSP7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP7: view

Variants for DUSP7 Gene

Sequence variations from dbSNP and Humsavar for DUSP7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1127035 -- 52,049,129(-) TCTCT(C/T)TTTTT utr-variant-3-prime
rs2164559 -- 52,051,075(+) GATGC(C/T)TGCCA missense, reference
rs3211267 -- 52,050,406(-) TTTTT(C/G/T)TTTTT utr-variant-3-prime
rs3211268 -- 52,050,400(-) ttttt(G/T)ttttt utr-variant-3-prime
rs3211269 -- 52,050,238(-) ttttt(G/T)ttttt utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP7 Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv876780 CNV Loss 21882294
nsv519445 CNV Gain+Loss 19592680
nsv876786 CNV Loss 21882294
nsv508923 CNV Insertion 20534489
esv25634 CNV Loss 19812545

Relevant External Links for DUSP7 Gene

HapMap Linkage Disequilibrium report
DUSP7

Disorders for DUSP7 Gene

No disorders were found for DUSP7 Gene.

No data available for UniProtKB/Swiss-Prot for DUSP7 Gene

Publications for DUSP7 Gene

  1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A. … Ashworth A. (Genomics 1997) 2 3 23
  2. Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. (PMID: 9788880) Dowd S. … Keyse S.M. (J. Cell. Sci. 1998) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. (PMID: 14674243) Levy-Nissenbaum O. … Witz I.P. (Meth. Enzymol. 2003) 3 23
  5. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PMID: 8626780) Muda M. … Arkinstall S. (J. Biol. Chem. 1996) 2 3

Products for DUSP7 Gene

  • Addgene plasmids for DUSP7

Sources for DUSP7 Gene

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