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DUSP7 Gene

protein-coding   GIFtS: 64
GCID: GC03M052082

Dual Specificity Phosphatase 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 71 2     Dual Specificity Protein Phosphatase 72
PYST22 3 5     Dual-Specificity Phosphatase-72
Dual Specificity Protein Phosphatase PYST22 3     EC 3.1.3.163
MKPX2 5     EC 3.1.3.483

External Ids:    HGNC: 30731   Entrez Gene: 18492   Ensembl: ENSG000001640867   OMIM: 6027495   UniProtKB: Q168293   

Export aliases for DUSP7 gene to outside databases

Previous GC identifers: GC03M051176 GC03M051336 GC03M051940 GC03M052042 GC03M052059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP7 Gene:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based
protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both
tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate
MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM
600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved
C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades
mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress
responses (summary by Patterson et al., 2009 (PubMed 19228121)).(supplied by OMIM, Dec 2009)

GeneCards Summary for DUSP7 Gene:
DUSP7 (dual specificity phosphatase 7) is a protein-coding gene. Diseases associated with DUSP7 include acute leukemia, and bronchiolitis. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829
Function: Regulates the activity of the MAP kinase family in response to changes in the cellular environment.
PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for
transcription, translation or activation factors

Gene Wiki entry for DUSP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP7 gene promoter:
         HOXA9B   HOXA9   Nkx2-2   MyoD   AP-2gamma   Meis-1b   AP-2beta   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP7 promoter sequence
   Search Chromatin IP Primers for DUSP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21

DUSP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052082:  view genomic region     (about GC identifiers)

Start:
52,082,935 bp from pter      End:
52,090,566 bp from pter
Size:
7,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 7  
Size: 419 amino acids; 44957 Da
Caution: An out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the
alternative promoter. The expression of the in-frame product has not yet been shown
Secondary accessions: Q2M3J7 Q8NFJ0
Alternative promoter usage: 2 isoforms:  Q16829-1   Q16829-2   

Explore the universe of human proteins at neXtProt for DUSP7: NX_Q16829

Explore proteomics data for DUSP7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001938.2  
    ENSEMBL proteins: 
     ENSP00000417183   ENSP00000418566   ENSP00000296483  
    Reactome Protein details: Q16829

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 6):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q16829

    ProtoNet protein and cluster: Q16829

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS7_HUMAN, Q16829
    Function: Regulates the activity of the MAP kinase family in response to changes in the cellular environment.
    PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for
    transcription, translation or activation factors
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for DUSP7:
    dual specificity (tyr/thr) phosphatase 7,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI12907755
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IDA9788880
         
    DUSP7 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DUSP7:
     Altered focal adhesion (FA) or  Decreased TP53 protein express  Increased Akt phosphorylation   Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP7
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    miRTarBase miRNAs that target DUSP7:
    hsa-let-7c-5p (MIRT051779), hsa-mir-760 (MIRT036734), hsa-mir-26b-5p (MIRT029270)

    Block miRNA regulation of human, mouse, rat DUSP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP7 (see all 71):
    hsa-miR-548j hsa-miR-132* hsa-miR-193a-3p hsa-miR-1321 hsa-miR-200a hsa-miR-548a-5p hsa-miR-200b hsa-miR-4293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS7_HUMAN, Q16829: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol IDA9788880

    DUSP7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP7 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    ERKs are inactivated0.00
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DUSP7
        JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for DUSP7
        Signal transduction Erk Interactions- Inhibition of Erk

    1 BioSystems Pathway for DUSP7
        MAPK signaling pathway

    1 Reactome Pathway for DUSP7
        ERKs are inactivated


    1 Kegg Pathway  (Kegg details for DUSP7):
        MAPK signaling pathway


    DUSP7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP7: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for DUSP7 (Q168291, 2, 3 ENSP000002964834) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GHRP109121, 2, 3, ENSP000002308824EBI-1265847,EBI-286316 MINT-6797534 I2D: score=3 STRING: ENSP00000230882
    MAPK1P284822, 3, ENSP000002158324MINT-8209385 MINT-8209376 I2D: score=4 STRING: ENSP00000215832
    EEF1A1P681042, 3, ENSP000003300544MINT-8254811 I2D: score=2 STRING: ENSP00000330054
    MAPK14Q165392, 3, ENSP000002297944MINT-8209366 MINT-8209356 I2D: score=3 STRING: ENSP00000229794
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006470protein dephosphorylation ----

    DUSP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP7 (DUS7)

    3 HMDB Compounds for DUSP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DUSP7 gene: 
    NM_001947.3  

    Unigene Cluster for DUSP7:

    Dual specificity phosphatase 7
    Hs.591664  [show with all ESTs]
    Unigene Representative Sequence: NM_001947
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495880(uc003dct.3) ENST00000469623(uc010hma.2) ENST00000296483

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    hsa-miR-548j hsa-miR-132* hsa-miR-193a-3p hsa-miR-1321 hsa-miR-200a hsa-miR-548a-5p hsa-miR-200b hsa-miR-4293
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    Additional mRNA sequence: 

    AF508727.1 AF508728.1 AL110157.1 BC019107.2 BC104880.1 BC104882.1 BC128064.1 X93921.1 

    4 DOTS entries:

    DT.409384  DT.75101263  DT.95159801  DT.95367075 

    Selected AceView cDNA sequences (see all 70):

    AI202182 AL110157 BM772606 AI362689 AF508728 BU178722 NM_001947 BC019107 
    BQ024545 AA782293 BU753703 AW953476 T09370 AW631273 AI681665 BX279928 
    BX111704 AI681699 N52350 AF508727 F08899 AW083474 D20943 X93921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP7 expression in normal human tissues (normalized intensities)      DUSP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCTCTTTT
    DUSP7 Expression
    About this image


    DUSP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    DUSP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591664

    UniProtKB/Swiss-Prot: DUS7_HUMAN, Q16829
    Tissue specificity: Expressed at significantly higher levels in malignant hematopoietic cells than in
    corresponding non-malignant cells

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP7: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp71 , 5 dual specificity phosphatase 71, 5 92.44(n)1
    97.85(a)1
      9 (57.46 cM)5
    2355841  NM_153459.41  NP_703189.31 
     1063686325 
    chicken
    (Gallus gallus)
    Aves DUSP76
    dual specificity phosphatase 7
    86(a)
    1 ↔ 1
    12(203478-212534)
    lizard
    (Anolis carolinensis)
    Reptilia DUSP76
    dual specificity phosphatase 7
    82(a)
    1 ↔ 1
    2(153857315-153869399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.143132 Transcribed sequence with weak similarity to protein more 75.18(n)    137716477 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp71 dual specificity phosphatase 7 80.22(n)
    84.89(a)
      327246  NM_199774.2  NP_956068.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mkp31 , 3 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more3
    Mitogen-activated protein kinase phosphatase 31
    42(a)3
    52.91(n)1
    44.88(a)1
      75F63
    400811  NM_140830.21  NP_649087.11 
    worm
    (Caenorhabditis elegans)
    Secernentea lip-13 protein-tyrosine phosphatase 53(a)   IV(6843152-6845014)   --


    ENSEMBL Gene Tree for DUSP7 (if available)
    TreeFam Gene Tree for DUSP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP7 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP92  
    DUSP22  DUSP82  DUSP12  SSH12  
    12 SIMAP similar genes for DUSP7 using alignment to 2 protein entries:     DUS7_HUMAN (see all proteins):
    DUSP6    DUSP9    DUSP19    DUSP22    DUSP14    DUSP3
    DUSP1    DUSP21    DUSP4    DUSP18    DUSP2    DUSP5

    DUSP7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP7 (see all 189)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483040021,2
    --52082538(+) ACCCAA/CACGGC 1 -- int10--------
    rs1430712381,2
    --52082588(+) GGCAAC/TGCCTA 1 -- int10--------
    rs1884280381,2
    --52082605(+) CAGCCG/TCAGAC 1 -- int10--------
    rs1931880041,2
    --52082929(+) GACACA/GACTCA 1 -- int10--------
    rs1387603841,2
    C--52082994(+) TCGGG-/ATATATA 1 -- ut310--------
    rs1854649331,2
    C--52083091(+) CATACC/TCTCAT 1 -- ut310--------
    rs1892462371,2
    --52083159(+) AGAGAA/GCCATG 1 -- ut310--------
    rs1474853941,2
    C--52083497(+) TGCCCC/TACTTG 1 -- ut310--------
    rs743288881,2
    F--52083651(+) AGGTCG/AGGCTG 1 -- ut311Minor allele frequency- A:0.01EA 120
    rs1166611521,2
    C,F--52083686(+) AGCCAC/GTGGGC 1 -- ut311Minor allele frequency- G:0.02NA 120

    HapMap Linkage Disequilibrium report for DUSP7 (52082935 - 52090566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DUSP7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508923CNV Insertion20534489
    nsv876786CNV Loss21882294
    nsv876780CNV Loss21882294
    esv25634CNV Loss19812545
    nsv520211CNV Gain19592680
    nsv519445CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602749    OMIM disorders: --

    6 diseases for DUSP7:    About MalaCards
    acute leukemia    bronchiolitis    malaria    myeloid leukemia
    leukemia    cerebritis


    DUSP7 for disorders           About GeneDecksing


    Export disorders for DUSP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP7 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DUSP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3, 9 Smith A....Ashworth A. (Genomics 1997)
    2. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. (PubMed id 14603440)1, 2 Levy-Nissenbaum O.... Witz I.P. (Genes Chromosomes Cancer 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. (PubMed id 14576828)1, 2 Levy-Nissenbaum O.... Witz I.P. (Oncogene 2003)
    5. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PubMed id 8626780)1, 3 Muda M....Arkinstall S. (J. Biol. Chem. 1996)
    6. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. (PubMed id 8670865)1, 2 Groom L.A.... Keyse S.M. (EMBO J. 1996)
    7. Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. (PubMed id 9788880)1, 9 Dowd S....Keyse S.M. (J. Cell. Sci. 1998)
    8. cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. (PubMed id 14674243)1, 9 Levy-Nissenbaum O....Witz I.P. (Meth. Enzymol. 2003)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1849 HGNC: 3073 AceView: DUSP7 Ensembl:ENSG00000164086 euGenes: HUgn1849
    ECgene: DUSP7 Kegg: 1849 H-InvDB: DUSP7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP7 gene:
    Search GeneIP for patents involving DUSP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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