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Aliases for DUSP6 Gene

Aliases for DUSP6 Gene

  • Dual Specificity Phosphatase 6 2 3
  • PYST1 3 4 6
  • MKP3 3 4 6
  • Mitogen-Activated Protein Kinase Phosphatase 3 3 4
  • Dual Specificity Protein Phosphatase PYST1 3 4
  • MAP Kinase Phosphatase 3 3 4
  • HH19 3 6
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 6 3
  • EC 4
  • EC 4
  • MKP-3 4

External Ids for DUSP6 Gene

Previous GeneCards Identifiers for DUSP6 Gene

  • GC12M089159
  • GC12M090189
  • GC12M089674
  • GC12M088244
  • GC12M089741
  • GC12M086807

Summaries for DUSP6 Gene

Entrez Gene Summary for DUSP6 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

GeneCards Summary for DUSP6 Gene

DUSP6 (Dual Specificity Phosphatase 6) is a Protein Coding gene. Diseases associated with DUSP6 include hypogonadotropic hypogonadism 19 with or without anosmia and normosmic congenital hypogonadotropic hypogonadism. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP6 Gene

  • Inactivates MAP kinases. Has a specificity for the ERK family

Gene Wiki entry for DUSP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP6 Gene

Genomics for DUSP6 Gene

Regulatory Elements for DUSP6 Gene

Transcription factor binding sites by QIAGEN in the DUSP6 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP6 Gene

89,347,232 bp from pter
89,353,271 bp from pter
6,040 bases
Minus strand

Genomic View for DUSP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP6 Gene

Proteins for DUSP6 Gene

  • Protein details for DUSP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 6
    Protein Accession:
    Secondary Accessions:
    • O75109
    • Q53Y75
    • Q9BSH6

    Protein attributes for DUSP6 Gene

    381 amino acids
    Molecular mass:
    42320 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP6 Gene

    Alternative splice isoforms for DUSP6 Gene


neXtProt entry for DUSP6 Gene

Proteomics data for DUSP6 Gene at MOPED

Post-translational modifications for DUSP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP6 (MKP-3)

No data available for DME Specific Peptides for DUSP6 Gene

Domains for DUSP6 Gene

Gene Families for DUSP6 Gene

  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

Graphical View of Domain Structure for InterPro Entry



  • Q16828
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP6: view

Function for DUSP6 Gene

Molecular function for DUSP6 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 6,including two transcripts,ubiquitously expressed,involved in signal transduction altered in pancreatic ductal carcinogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Inactivates MAP kinases. Has a specificity for the ERK family

Enzyme Numbers (IUBMB) for DUSP6 Gene

Gene Ontology (GO) - Molecular Function for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUSP6: view
genes like me logo Genes that share phenotypes with DUSP6: view

Animal Models for DUSP6 Gene

MGI Knock Outs for DUSP6:

Animal Model Products

miRNA for DUSP6 Gene

miRTarBase miRNAs that target DUSP6

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP6

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DUSP6 Gene

Localization for DUSP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP6 Gene


Subcellular locations from

Jensen Localization Image for DUSP6 Gene COMPARTMENTS Subcellular localization image for DUSP6 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 8670865
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with DUSP6: view

Pathways for DUSP6 Gene

genes like me logo Genes that share pathways with DUSP6: view

Pathways by source for DUSP6 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IDA 8670865
GO:0001933 negative regulation of protein phosphorylation --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with DUSP6: view

Compounds for DUSP6 Gene

(3) HMDB Compounds for DUSP6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • NFB Orthophosphate
  • Dihydrogen oxide

(12) Novoseek inferred chemical compound relationships for DUSP6 Gene

Compound -log(P) Hits PubMed IDs
cl 100 80.3 1
phosphothreonine 54 1
dmso 29.7 2
tyrosine 29.5 3
phosphotyrosine 24.6 1
genes like me logo Genes that share compounds with DUSP6: view

Transcripts for DUSP6 Gene

Unigene Clusters for DUSP6 Gene

Dual specificity phosphatase 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: -
SP4: - - -

Relevant External Links for DUSP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP6 Gene

mRNA expression in normal human tissues for DUSP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DUSP6 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP6 Gene

SOURCE GeneReport for Unigene cluster for DUSP6 Gene Hs.298654

genes like me logo Genes that share expressions with DUSP6: view

Expression partners for DUSP6 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP6 Gene

Orthologs for DUSP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP6 35
  • 94.4 (n)
  • 99.21 (a)
DUSP6 36
  • 99 (a)
(Canis familiaris)
Mammalia DUSP6 35
  • 93.88 (n)
  • 99.74 (a)
DUSP6 36
  • 100 (a)
(Mus musculus)
Mammalia Dusp6 35
  • 90.64 (n)
  • 98.16 (a)
Dusp6 16
Dusp6 36
  • 98 (a)
(Pan troglodytes)
Mammalia DUSP6 35
  • 99.65 (n)
  • 99.74 (a)
DUSP6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dusp6 35
  • 91.6 (n)
  • 98.69 (a)
(Monodelphis domestica)
Mammalia DUSP6 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP6 36
  • 93 (a)
(Gallus gallus)
Aves DUSP6 35
  • 85.21 (n)
  • 93.44 (a)
MKP3 36
  • 93 (a)
(Anolis carolinensis)
Reptilia DUSP6 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp6 35
  • 79.37 (n)
  • 88.62 (a)
Str.10337 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68682 35
(Danio rerio)
Actinopterygii dusp6 35
  • 73.77 (n)
  • 80.53 (a)
dusp6 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 37
  • 39 (a)
Mkp3 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea lip-1 37
  • 39 (a)
lip-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 36
  • 39 (a)
Species with no ortholog for DUSP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP6 Gene

Gene Tree for DUSP6 (if available)
Gene Tree for DUSP6 (if available)

Paralogs for DUSP6 Gene

Paralogs for DUSP6 Gene

Selected SIMAP similar genes for DUSP6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DUSP6: view

Variants for DUSP6 Gene

Sequence variations from dbSNP and Humsavar for DUSP6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10744 -- 89,348,127(-) AGTTT(A/T)GAGCT utr-variant-3-prime
rs704073 -- 89,347,934(-) TAGAA(C/T)GTTTT utr-variant-3-prime
rs704074 -- 89,348,954(-) GGTAG(A/G)ACCAA utr-variant-3-prime
rs704075 -- 89,349,446(-) AACGA(A/C/T)GCCTA missense, synonymous-codon, reference
rs704076 -- 89,350,144(-) GATGC(G/T)GTGAT intron-variant

Relevant External Links for DUSP6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

PCR Panel Products

  • Copy Number PCR Panels: for DUSP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUSP6 Gene

Disorders for DUSP6 Gene

(1) OMIM Diseases for DUSP6 Gene (602748)


  • Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in DUSP6 also have a heterozygous mutation in another HH-associated gene including FGFR1 and SPRY4 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

(2) Novoseek inferred disease relationships for DUSP6 Gene

Disease -log(P) Hits PubMed IDs
tumors 21.1 10
breast cancer 0 2

Relevant External Links for DUSP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DUSP6: view

No data available for University of Copenhagen DISEASES and Genatlas for DUSP6 Gene

Publications for DUSP6 Gene

  1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A. … Ashworth A. (Genomics 1997) 2 3 23
  2. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PMID: 8626780) Muda M. … Arkinstall S. (J. Biol. Chem. 1996) 2 3 23
  3. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. (PMID: 12840032) Kim H.S. … Lim I.K. (J. Biol. Chem. 2003) 3 23
  4. Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis. (PMID: 11998972) RAPssig L. … Dimmeler S. (Basic Res. Cardiol. 2002) 3 23
  5. Intramolecular dephosphorylation of ERK by MKP3. (PMID: 14690430) Kim Y. … Denu J.M. (Biochemistry 2003) 3 23

Products for DUSP6 Gene

  • Addgene plasmids for DUSP6

Sources for DUSP6 Gene

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