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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP6 Gene

protein-coding   GIFtS: 67
GCID: GC12M089741

Dual Specificity Phosphatase 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 61 2     HH192
MKP32 3 5     Dual Specificity Protein Phosphatase 62
PYST12 3 5     Serine/Threonine Specific Protein Phosphatase2
Dual Specificity Protein Phosphatase PYST12 3     EC 3.1.3.163
Mitogen-Activated Protein Kinase Phosphatase 32 3     EC 3.1.3.483
MAP Kinase Phosphatase 32 3     MKP-33

External Ids:    HGNC: 30721   Entrez Gene: 18482   Ensembl: ENSG000001393187   OMIM: 6027485   UniProtKB: Q168283   

Export aliases for DUSP6 gene to outside databases

Previous GC identifers: GC12M089159 GC12M090189 GC12M089674 GC12M088244 GC12M086807


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP6 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a
variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family,
is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP6 Gene: 
DUSP6 (dual specificity phosphatase 6) is a protein-coding gene. Diseases associated with DUSP6 include tuberous sclerosis complex, and inclusion body myositis, and among its related super-pathways are MAPK signaling pathway and MAP kinase activation in TLR cascade. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
Function: Inactivates MAP kinases. Has a specificity for the ERK family

Gene Wiki entry for DUSP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP6 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUSP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22-q23   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q22-q23

DUSP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M089741:  view genomic region     (about GC identifiers)

Start:
89,741,009 bp from pter      End:
89,747,048 bp from pter
Size:
6,040 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 6  
Size: 381 amino acids; 42320 Da
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for DUSP6:
1HZM (3D)        1MKP (3D)    
Secondary accessions: O75109 Q53Y75 Q9BSH6
Alternative splicing: 2 isoforms:  Q16828-1   Q16828-2   

Explore the universe of human proteins at neXtProt for DUSP6: NX_Q16828

Explore proteomics data for DUSP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16828

  • DUSP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUSP6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001937.2  NP_073143.2  

    ENSEMBL proteins: 
     ENSP00000279488   ENSP00000307835   ENSP00000449838   ENSP00000446858  
    Reactome Protein details: Q16828
    Human Recombinant Protein Products for DUSP6: 
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    Enzo Life Sciences proteins for DUSP6
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    OriGene Protein Over-expression Lysate for DUSP6
    OriGene MassSpec for DUSP6 
    OriGene Custom Protein Services for DUSP6
    GenScript Custom Purified and Recombinant Proteins Services for DUSP6
    Novus Biologicals DUSP6 Protein
    Novus Biologicals DUSP6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA8670865
    GO:0005829cytosol IBA--

    DUSP6 for ontologies           About GeneDecksing



    DUSP6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    5/6 InterPro protein domains (see all 6):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q16828

    ProtoNet protein and cluster: Q16828

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS6_HUMAN, Q16828
    Function: Inactivates MAP kinases. Has a specificity for the ERK family
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP6:
    dual specificity (tyr/thr) phosphatase 6,including two transcripts,ubiquitously expressed,involved in signal
    transduction altered in pancreatic ductal carcinogenesis

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    DUSP6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DUSP6:
     Increased HPV18 LCR reporter a  Increased apoptosis  Weaker migration 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dusp6):
     cardiovascular system  cellular  craniofacial  growth/size  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     skeleton 

    DUSP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dusp6tm1Jmol for DUSP6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP6 
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    miRNA
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    hsa-miR-1178 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-520d-5p hsa-miR-374a hsa-miR-1304 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidDUSP6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DUSP6 (NM_001946)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP6
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DUSP6 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    3ERK/MAPK targets
    ERK/MAPK targets0.88
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    Nuclear Events (kinase and transcription factor activation)0.88
    ERKs are inactivated0.57
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DUSP6
        Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP6
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP6
        Phosphatases
    MAP Kinase Signaling

    1 GeneGo (Thomson Reuters) Pathway for DUSP6
        Signal transduction Erk Interactions- Inhibition of Erk

    3 BioSystems Pathways for DUSP6
        MAPK signaling pathway
    B Cell Receptor Signaling Pathway
    ErbB1 downstream signaling

    5/28        Reactome Pathways for DUSP6 (see all 28)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade


    2         Kegg Pathways  (Kegg details for DUSP6):
        MAPK signaling pathway
    Transcriptional misregulation in cancer


    DUSP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/15 Interacting proteins for DUSP6 (Q168282, 3 ENSP000002794884) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8216560 I2D: score=5 STRING: ENSP00000215832
    TEX11Q8IYF32, 3, ENSP000003409954MINT-67633 I2D: score=5 STRING: ENSP00000340995
    MAPK3P273612, 3, ENSP000002630254MINT-8216553 I2D: score=5 STRING: ENSP00000263025
    MDFIQ997502, 3, ENSP000002303214MINT-66931 I2D: score=5 STRING: ENSP00000230321
    MAPK14Q165393, ENSP000002297944I2D: score=1 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IDA8670865
    GO:0001933negative regulation of protein phosphorylation ----
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    DUSP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP6 (DUS6)

    3 HMDB Compounds for DUSP6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/12 Novoseek inferred chemical compound relationships for DUSP6 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 80.3 1 10085148 (1)
    phosphothreonine 54 2 9596579 (1)
    dmso 29.7 2 17459723 (1), 10702230 (1)
    tyrosine 29.5 5 15240129 (1), 8626780 (1), 16834321 (1)
    phosphotyrosine 24.6 2 9596579 (1)
    pd 98,059 20 1 16740736 (1)
    phenylephrine 10.9 1 10085148 (1)
    h2o2 1.73 2 16834321 (1), 18632752 (1)
    cysteine 1.4 6 16834321 (4), 15541888 (1)
    oxygen 0 3 18245669 (1), 12840032 (1), 18632752 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP6 / DUS6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP6 gene (2 alternative transcripts): 
    NM_001946.2  NM_022652.2  

    Unigene Clusters for DUSP6:

    Dual specificity phosphatase 6
    Hs.298654  [show with all ESTs], Hs.718640  [show with all ESTs]
    Unigene Representative Sequences: BC037236, AK124265
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279488(uc001tay.3 uc001taz.3) ENST00000308385 ENST00000547291
    ENST00000547140 ENST00000548755
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP6
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP6

    Additional mRNA sequence: 

    AB189400.1 AK124265.1 

    18 DOTS entries:

    DT.318611  DT.107281  DT.95131012  DT.121191240  DT.100798046  DT.121191243  DT.100030226  DT.121191261 
    DT.100798052  DT.92043785  DT.100798049  DT.100798050  DT.100798057  DT.100798054  DT.100798056  DT.121191256 
    DT.95128523  DT.95131005 

    24/401 AceView cDNA sequences (see all 401):

    BM837461 CD370923 AA857239 AI433775 CB135969 AI573117 AI251112 CD517158 
    BQ575958 AI092872 AU138755 AA630374 BM473580 AI380266 BQ001889 AA405450 
    AA776489 R62605 CO245194 BQ221007 CB114335 BQ434348 AW088518 CB962003 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                                -     -                                 
    SP2:                                      -                                 
    SP3:                                                                        
    SP4:                                -     -     -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for DUSP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP6 expression in normal human tissues (normalized intensities)      DUSP6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTACCCATT
    DUSP6 Expression
    About this image


    DUSP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             visceral organ/oral region/upper jaw   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Epithelial Tubule
             visceral organ/metanephros/nephrogenic zone   
     
     Somite (Muscoskeletal System)    fully expand to see all 4 entries
             Tendon Progenitor Cells Thoracic Syndetome
     
     Tendon & Ligament
             Tendon Progenitor Cells Thoracic Syndetome
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Mature Granulosa Cells Antral Follicle
             Secondary follicles

    See DUSP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP6

    SOURCE GeneReport for Unigene clusters: Hs.298654 Hs.718640
        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP6: 
              Lung Cancer in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DUSP6 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp61 , 5 dual specificity phosphatase 61, 5 90.64(n)1
    98.16(a)1
      10 (51.13 cM)5
    676031  NM_026268.31  NP_080544.11 
     992632315 
    chicken
    (Gallus gallus)
    Aves DUSP61 dual specificity phosphatase 6 85.21(n)
    93.44(a)
      374272  NM_204354.1  NP_989685.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP66
    Dual specificity protein phosphatase
    79(a)
    1 ↔ 1
    5(32944411-32958309)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686822 hypothetical protein MGC68682 80.97(n)    BC059985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp62 dual specificity phosphatase 6 76.09(n)   353314  AY278203.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mkp33 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    39(a)   75F6   --


    ENSEMBL Gene Tree for DUSP6 (if available)
    TreeFam Gene Tree for DUSP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP6 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP142  DUSP282  DUSP82  DUSP72  
    DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    13 SIMAP similar genes for DUSP6 using alignment to 5 protein entries:     DUS6_HUMAN (see all proteins):
    DUSP7    DUSP9    DUSP19    DUSP22    DUSP10    DUSP3
    DUSP14    DUSP8    DUSP16    DUSP1    DUSP2    DUSP4
    DUSP5

    DUSP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/189 SNPs in DUSP6 are shown (see all 189)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7960491,2
    C,F,A,H--89741438(+) TTATAA/GAGCAG 2 -- ds500116Minor allele frequency- G:0.11EA NS NA WA CSA 2174
    rs1412674781,2
    --89741563(+) TATAGA/GTTCAT 2 -- ds50010--------
    rs1927979251,2
    --89741630(+) TCATAC/TACACG 2 -- ds50010--------
    rs7040731,2
    C,F,A,H--89741711(-) TAGAAC/TGTTTT 2 -- ds500128Minor allele frequency- T:0.24MN NS EA NA WA CSA 2844
    rs1500037611,2
    C--89741821(+) CTGAG-/TTT   
      TTAAAA
    ACACA
    2 -- ds50010--------
    rs762944341,2
    C--89741839(+) ACATTA/CAATAG 2 -- ut310--------
    rs107441,2
    C,F,O,A,H--89741904(-) AGTTTA/TGAGCT 2 -- ut31 ese314Minor allele frequency- T:0.33MN NS EA NA WA CSA 1040
    rs732103611,2
    --89741969(+) ATTTCC/TCTTAT 2 -- ut310--------
    rs1507610211,2
    --89742102(+) TAATAA/TACTGT 2 -- ut310--------
    rs1845876381,2
    --89742132(+) TTTTAC/TTCTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP6 (89741009 - 89747048 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DUSP6: --

    Human Gene Mutation Database (HGMD): DUSP6
    SABiosciences Cancer Mutation PCR Assays
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    Pancreatic Cancer
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602748    OMIM disorders: --

    20/22 diseases for DUSP6 (see all 22):    About MalaCards
    tuberous sclerosis complex    inclusion body myositis    myositis    tuberous sclerosis
    non-small cell lung carcinoma    scoliosis    bipolar disorder    thyroid cancer
    pancreatic cancer    hypoxia    glioblastoma    schizophrenia
    colon cancer    lung cancer    pancreatitis    ischemia
    endotheliitis    ovarian cancer    breast cancer    melanoma


    DUSP6 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DUSP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 21.1 14 15832194 (3), 18771677 (1), 15240129 (1), 18694935 (1) (see all 8)
    breast cancer 0 2 16740736 (2)

    Genetic Association Database (GAD): DUSP6
    Human Genome Epidemiology (HuGE) Navigator: DUSP6 (6 documents)

    Export disorders for DUSP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP6 gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with DUSP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PubMed id 8626780)1, 3, 9 Muda M....Arkinstall S. (1996)
    2. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3, 9 Smith A....Ashworth A. (1997)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. (PubMed id 10048930)1, 2 Stewart A.E.... McDonald N.Q. (1999)
    8. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. (PubMed id 9858808)1, 2 Furukawa T....Horii A. (1998)
    9. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. (PubMed id 8670865)1, 2 Groom L.A.... Keyse S.M. (1996)
    10. Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. (PubMed id 18771677)1, 9 Zeliadt N.A....Wattenberg E.V. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1848 HGNC: 3072 AceView: DUSP6 Ensembl:ENSG00000139318 euGenes: HUgn1848
    ECgene: DUSP6 Kegg: 1848 H-InvDB: DUSP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP6 gene:
    Search GeneIP for patents involving DUSP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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