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DUSP6 Gene

protein-coding   GIFtS: 67
GCID: GC12M089741

Dual Specificity Phosphatase 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 61 2     HH192 5
MKP32 3 5     Dual Specificity Protein Phosphatase 62
PYST12 3 5     Serine/Threonine Specific Protein Phosphatase2
Dual Specificity Protein Phosphatase PYST12 3     EC 3.1.3.163
Mitogen-Activated Protein Kinase Phosphatase 32 3     EC 3.1.3.483
MAP Kinase Phosphatase 32 3     MKP-33

External Ids:    HGNC: 30721   Entrez Gene: 18482   Ensembl: ENSG000001393187   OMIM: 6027485   UniProtKB: Q168283   

Export aliases for DUSP6 gene to outside databases

Previous GC identifers: GC12M089159 GC12M090189 GC12M089674 GC12M088244 GC12M086807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP6 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a
variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family,
is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic
hypogonadism. Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Jan
2014)

GeneCards Summary for DUSP6 Gene:
DUSP6 (dual specificity phosphatase 6) is a protein-coding gene. Diseases associated with DUSP6 include hypogonadotropic hypogonadism 19 with or without anosmia, and tuberous sclerosis complex. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
Function: Inactivates MAP kinases. Has a specificity for the ERK family

Gene Wiki entry for DUSP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP6 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUSP6 promoter sequence
   Search Chromatin IP Primers for DUSP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22-q23   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q22-q23

DUSP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M089741:  view genomic region     (about GC identifiers)

Start:
89,741,009 bp from pter      End:
89,747,048 bp from pter
Size:
6,040 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 6  
Size: 381 amino acids; 42320 Da
2 PDB 3D structures from and Proteopedia for DUSP6:
1HZM (3D)        1MKP (3D)    
Secondary accessions: O75109 Q53Y75 Q9BSH6
Alternative splicing: 2 isoforms:  Q16828-1   Q16828-2   

Explore the universe of human proteins at neXtProt for DUSP6: NX_Q16828

Explore proteomics data for DUSP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001937.2  NP_073143.2  

    ENSEMBL proteins: 
     ENSP00000279488   ENSP00000307835   ENSP00000449838   ENSP00000446858  
    Reactome Protein details: Q16828

    DUSP6 Human Recombinant Protein Products:

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    Novus Biologicals DUSP6 Lysates
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    DUSP6 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DUSP6

    DUSP6 Assay Products:

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    Cloud-Clone Corp. ELISAs for DUSP6
    Cloud-Clone Corp. CLIAs for DUSP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 6):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q16828

    ProtoNet protein and cluster: Q16828

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS6_HUMAN, Q16828
    Function: Inactivates MAP kinases. Has a specificity for the ERK family
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for DUSP6:
    dual specificity (tyr/thr) phosphatase 6,including two transcripts,ubiquitously expressed,involved in signal
    transduction altered in pancreatic ductal carcinogenesis

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
         
    DUSP6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DUSP6:
     Increased HPV18 LCR reporter a  Increased apoptosis  Weaker migration 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dusp6):
     cardiovascular system  cellular  craniofacial  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     skeleton 

    DUSP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dusp6tm1Jmol for DUSP6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP6

    miRNA
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    miRTarBase miRNAs that target DUSP6:
    hsa-mir-181a-5p (MIRT006481), hsa-mir-375 (MIRT020032), hsa-mir-335-5p (MIRT018633)

    Block miRNA regulation of human, mouse, rat DUSP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP6 (see all 22):
    hsa-miR-1178 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-520d-5p hsa-miR-374a hsa-miR-1304 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidDUSP6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DUSP6
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP6

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DUSP6 (see all 13)
    OriGene ORF clones in mouse, rat for DUSP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DUSP6 (NM_001946)
    Sino Biological Human cDNA Clone for DUSP6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS6_HUMAN, Q16828: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA8670865
    GO:0005829cytosol IBA--

    DUSP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP6 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    ERKs are inactivated0.00
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DUSP6
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP6
        Phosphatases
    MAP Kinase Signaling

    1 GeneGo (Thomson Reuters) Pathway for DUSP6
        Signal transduction Erk Interactions- Inhibition of Erk

    3 BioSystems Pathways for DUSP6
        MAPK signaling pathway
    B Cell Receptor Signaling Pathway
    ErbB1 downstream signaling


    1 Reactome Pathway for DUSP6
        ERKs are inactivated


    2 Kegg Pathways  (Kegg details for DUSP6):
        MAPK signaling pathway
    Transcriptional misregulation in cancer


    DUSP6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DUSP6: 
              Lung Cancer in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for DUSP6 (Q168282, 3 ENSP000002794884) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8216560 I2D: score=5 STRING: ENSP00000215832
    TEX11Q8IYF32, 3, ENSP000003409954MINT-67633 I2D: score=5 STRING: ENSP00000340995
    MAPK3P273612, 3, ENSP000002630254MINT-8216553 I2D: score=5 STRING: ENSP00000263025
    MDFIQ997502, 3, ENSP000002303214MINT-66931 I2D: score=5 STRING: ENSP00000230321
    MAPK14Q165393, ENSP000002297944I2D: score=1 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IDA8670865
    GO:0001933negative regulation of protein phosphorylation ----
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    DUSP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP6 (DUS6)

    3 HMDB Compounds for DUSP6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for DUSP6 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 80.3 1 10085148 (1)
    phosphothreonine 54 2 9596579 (1)
    dmso 29.7 2 17459723 (1), 10702230 (1)
    tyrosine 29.5 5 15240129 (1), 8626780 (1), 16834321 (1)
    phosphotyrosine 24.6 2 9596579 (1)
    pd 98,059 20 1 16740736 (1)
    phenylephrine 10.9 1 10085148 (1)
    h2o2 1.73 2 16834321 (1), 18632752 (1)
    cysteine 1.4 6 16834321 (4), 15541888 (1)
    oxygen 0 3 18245669 (1), 12840032 (1), 18632752 (1)



    DUSP6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DUSP6 gene (2 alternative transcripts): 
    NM_001946.3  NM_022652.3  

    Unigene Cluster for DUSP6:

    Dual specificity phosphatase 6
    Hs.298654  [show with all ESTs]
    Unigene Representative Sequence: BC037236
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279488(uc001tay.3 uc001taz.3) ENST00000308385 ENST00000547291
    ENST00000547140 ENST00000548755
    miRNA
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    hsa-miR-1178 hsa-miR-3910 hsa-miR-125a-5p hsa-miR-4328 hsa-miR-520d-5p hsa-miR-374a hsa-miR-1304 hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidDUSP6 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP6
    Primer
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    OriGene qPCR primer pairs and template standards for DUSP6
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP6
      QuantiTect SYBR Green Assays in human, mouse, rat DUSP6
      QuantiFast Probe-based Assays in human, mouse, rat DUSP6

    Additional mRNA sequence: 

    AB013382.1 AB013602.1 AB451265.1 AB451393.1 AK091753.1 AK222882.1 BC003143.1 BC003562.1 
    BC005047.1 BC037236.1 BT006895.1 X93920.1 

    10 DOTS entries:

    DT.318611  DT.95131012  DT.100030226  DT.100798052  DT.92043785  DT.100798057  DT.100798054  DT.107281 
    DT.100798056  DT.121191240 

    Selected AceView cDNA sequences (see all 401):

    BU789040 AI092872 AI433775 CD517158 AI192556 CD365332 BM818053 NM_022652 
    AA405450 AU121824 BQ221007 BQ575958 CB135969 AW290904 NM_001946 AA857239 
    CD613493 R62605 AI085452 BM918436 CB114320 AU131653 AU131995 CB137963 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                                -     -                                 
    SP2:                                      -                                 
    SP3:                                                                        
    SP4:                                -     -     -                           
    SP5:                                                                        


    ECgene alternative splicing isoforms for DUSP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DUSP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTACCCATT
    DUSP6 Expression
    About this image


    DUSP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Epithelial Tubule
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Mature Granulosa Cells Antral Follicle
             Secondary follicles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Ectoderm (Nervous System)
             Isthmus Cells Neural Plate
     
     Neural Tube (Nervous System)
             Isthmus Cells Neural Plate
    DUSP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.298654
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DUSP6: 
              Lung Cancer in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DUSP6
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP6
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    QuantiFast Probe-based Assays in human, mouse, rat DUSP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp61 , 5 dual specificity phosphatase 61, 5 90.64(n)1
    98.16(a)1
      10 (51.13 cM)5
    676031  NM_026268.31  NP_080544.11 
     992632315 
    chicken
    (Gallus gallus)
    Aves DUSP61 dual specificity phosphatase 6 85.21(n)
    93.44(a)
      374272  NM_204354.1  NP_989685.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP66
    dual specificity phosphatase 6
    79(a)
    1 ↔ 1
    5(32944411-32958309)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686822 hypothetical protein MGC68682 80.97(n)    BC059985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp62 dual specificity phosphatase 6 76.09(n)   353314  AY278203.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mkp33 protein amino acid dephosphorylation
    protein tyrosine/serine/threonine
    more
    39(a)   75F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea lip-13 protein-tyrosine phosphatase 39(a)   IV(6843152-6845014)   --


    ENSEMBL Gene Tree for DUSP6 (if available)
    TreeFam Gene Tree for DUSP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP6 gene
    DUSP42  SSH22  DUSP52  DUSP102  SSH32  DUSP162  DUSP92  DUSP22  
    DUSP82  DUSP12  DUSP72  SSH12  
    13 SIMAP similar genes for DUSP6 using alignment to 5 protein entries:     DUS6_HUMAN (see all proteins):
    DUSP7    DUSP9    DUSP19    DUSP22    DUSP10    DUSP3
    DUSP14    DUSP8    DUSP16    DUSP1    DUSP2    DUSP4
    DUSP5

    DUSP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP6 (see all 193)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460895051,2,,4
    CHypogonadotropic hypogonadism 19 with or without anosmia (HH19)4 --89743140(+) CCAGCG/ATCCTC 4 /T /M mis11Minor allele frequency- A:0.00EU 1321
    rs1439467941,2,,4
    CHypogonadotropic hypogonadism 19 with or without anosmia (HH19)4 --89744637(+) CACTAT/CTGGGG 3 /N /S mis1 int11Minor allele frequency- C:0.00NA 4552
    VAR_0699434
    Hypogonadotropic hypogonadism 19 with or without anosmia (HH19)4--see VAR_0699432 F I mis40--------
    VAR_0699444
    Hypogonadotropic hypogonadism 19 with or without anosmia (HH19)4--see VAR_0699442 S F mis40--------
    rs7960491,2
    C,F,A,H--89741438(+) TTATAA/GAGCAG 2 -- ds500116Minor allele frequency- G:0.11EA NS NA WA CSA 2174
    rs1412674781,2
    --89741563(+) TATAGA/GTTCAT 2 -- ds50010--------
    rs1927979251,2
    --89741630(+) TCATAC/TACACG 2 -- ds50010--------
    rs7040731,2
    C,F,A,H--89741711(-) TAGAAC/TGTTTT 2 -- ds500128Minor allele frequency- T:0.24MN NS EA NA WA CSA 2844
    rs1500037611,2
    C--89741821(+) CTGAG-/TTT   
      TTAAAA
    ACACA
    2 -- ds50010--------
    rs762944341,2
    C--89741839(+) ACATTA/CAATAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP6 (89741009 - 89747048 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DUSP6: --
    Human Gene Mutation Database (HGMD): DUSP6
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing DUSP6:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing DUSP6
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602748   
    OMIM disorders: 615269  
    UniProtKB/Swiss-Prot: DUS6_HUMAN, Q16828
  • Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations
    in DUSP6 also have a heterozygous mutation in another HH-associated gene including FGFR1 and SPRY4
    (PubMed:23643382)

  • Selected diseases for DUSP6 (see all 22):    
    About MalaCards
    hypogonadotropic hypogonadism 19 with or without anosmia    tuberous sclerosis complex    hypogonadotropic hypogonadism 17 with or without anosmia    hypogonadotropic hypogonadism 8 with or without anosmia
    inclusion body myositis    tuberous sclerosis    myositis    thyroid cancer
    bipolar disorder    hypoxia    pancreatic cancer    thyroiditis
    ischemia    endotheliitis    schizophrenia    lung cancer
    pancreatitis    ovarian cancer    breast cancer    cervicitis


    DUSP6 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DUSP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 21.1 14 15832194 (3), 18771677 (1), 15240129 (1), 18694935 (1) (see all 8)
    breast cancer 0 2 16740736 (2)

    Genetic Association Database (GAD): DUSP6
    Human Genome Epidemiology (HuGE) Navigator: DUSP6 (6 documents)

    Export disorders for DUSP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP6 gene, integrated from 10 sources (see all 140):
    (articles sorted by number of sources associating them with DUSP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PubMed id 8626780)1, 3, 9 Muda M....Arkinstall S. (J. Biol. Chem. 1996)
    2. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3, 9 Smith A....Ashworth A. (Genomics 1997)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. (PubMed id 10048930)1, 2 Stewart A.E.... McDonald N.Q. (Nat. Struct. Biol. 1999)
    8. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. (PubMed id 9858808)1, 2 Furukawa T....Horii A. (Cytogenet. Cell Genet. 1998)
    9. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. (PubMed id 8670865)1, 2 Groom L.A.... Keyse S.M. (EMBO J. 1996)
    10. Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. (PubMed id 18771677)1, 9 Zeliadt N.A....Wattenberg E.V. (Toxicol. Appl. Pharmacol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1848 HGNC: 3072 AceView: DUSP6 Ensembl:ENSG00000139318 euGenes: HUgn1848
    ECgene: DUSP6 Kegg: 1848 H-InvDB: DUSP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP6 gene:
    Search GeneIP for patents involving DUSP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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