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Aliases for DUSP6 Gene

Aliases for DUSP6 Gene

  • Dual Specificity Phosphatase 6 2 3 5
  • Mitogen-Activated Protein Kinase Phosphatase 3 3 4
  • Dual Specificity Protein Phosphatase PYST1 3 4
  • MAP Kinase Phosphatase 3 3 4
  • PYST1 3 4
  • MKP3 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 6 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • MKP-3 4
  • HH19 3

External Ids for DUSP6 Gene

Previous GeneCards Identifiers for DUSP6 Gene

  • GC12M089159
  • GC12M090189
  • GC12M089674
  • GC12M088244
  • GC12M089741
  • GC12M086807

Summaries for DUSP6 Gene

Entrez Gene Summary for DUSP6 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

GeneCards Summary for DUSP6 Gene

DUSP6 (Dual Specificity Phosphatase 6) is a Protein Coding gene. Diseases associated with DUSP6 include Hypogonadotropic Hypogonadism 19 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism. Among its related pathways are Activated TLR4 signalling and RET signaling. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP7.

UniProtKB/Swiss-Prot for DUSP6 Gene

  • Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).

Gene Wiki entry for DUSP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP6 Gene

Genomics for DUSP6 Gene

Regulatory Elements for DUSP6 Gene

Enhancers for DUSP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F089179 1.6 FANTOM5 Ensembl ENCODE 41.6 +172.4 172371 3.4 HDGF ATF1 ARNT CREB3L1 BRCA1 ZNF766 FOS NCOA1 KAT8 CREB3 DUSP6 RNU7-120P ATP2B1 POC1B LOC105378255 LOC100287355
GH12F089159 1.6 FANTOM5 Ensembl ENCODE 37.6 +189.6 189580 7.8 SIN3A YY1 GATA2 CBX5 FOS JUNB TBX21 MEF2D MAFF ZNF585B DUSP6 RNU7-120P ATP2B1 POC1B LOC105378255 LOC100287355
GH12F089155 1.4 FANTOM5 Ensembl ENCODE 29.3 +196.2 196212 3.7 CTCF JUN MAX RAD21 YY1 HNF4G NR2F6 MIXL1 SOX5 GATAD2A DUSP6 RNU7-120P ATP2B1 LOC105378255 LOC100287355
GH12F089038 1.3 FANTOM5 Ensembl ENCODE 30.8 +313.5 313465 2.4 CTCF GTF2E2 MAX FEZF1 ZIC2 CBX5 SCRT2 ETV6 CREM SCRT1 DUSP6 GALNT4 POC1B LOC100287355 LOC105378255
GH12F089234 1.6 FANTOM5 Ensembl ENCODE 24.5 +116.4 116359 5.0 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 MXD4 MIER2 PPARG KAT8 DUSP6 RNU7-120P ENSG00000258302 ATP2B1 LOC105378255 GC12M089283
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP6 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001779529 871 6001 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS

Transcription factor binding sites by QIAGEN in the DUSP6 gene promoter:

Genomic Location for DUSP6 Gene

Chromosome:
12
Start:
89,347,232 bp from pter
End:
89,353,271 bp from pter
Size:
6,040 bases
Orientation:
Minus strand

Genomic View for DUSP6 Gene

Genes around DUSP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP6 Gene

Proteins for DUSP6 Gene

  • Protein details for DUSP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16828-DUS6_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 6
    Protein Accession:
    Q16828
    Secondary Accessions:
    • O75109
    • Q53Y75
    • Q9BSH6

    Protein attributes for DUSP6 Gene

    Size:
    381 amino acids
    Molecular mass:
    42320 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP6 Gene

    Alternative splice isoforms for DUSP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP6 Gene

Post-translational modifications for DUSP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP6 (MKP-3)
  • Abcam antibodies for DUSP6
  • Cloud-Clone Corp. Antibodies for DUSP6

No data available for DME Specific Peptides for DUSP6 Gene

Domains & Families for DUSP6 Gene

Gene Families for DUSP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q16828

UniProtKB/Swiss-Prot:

DUS6_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP6: view

Function for DUSP6 Gene

Molecular function for DUSP6 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 6,including two transcripts,ubiquitously expressed,involved in signal transduction altered in pancreatic ductal carcinogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).

Enzyme Numbers (IUBMB) for DUSP6 Gene

Gene Ontology (GO) - Molecular Function for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity TAS --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP6: view
genes like me logo Genes that share phenotypes with DUSP6: view

Human Phenotype Ontology for DUSP6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DUSP6 Gene

MGI Knock Outs for DUSP6:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP6

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DUSP6 Gene

Localization for DUSP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 8670865
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DUSP6: view

Pathways & Interactions for DUSP6 Gene

SuperPathways for DUSP6 Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 Nuclear Events (kinase and transcription factor activation)
4 MAPK signaling pathway
5 MAPK-Erk Pathway
genes like me logo Genes that share pathways with DUSP6: view

Pathways by source for DUSP6 Gene

2 Sino Biological pathways for DUSP6 Gene
1 Cell Signaling Technology pathway for DUSP6 Gene
2 BioSystems pathways for DUSP6 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP6 Gene
1 Qiagen pathway for DUSP6 Gene

SIGNOR curated interactions for DUSP6 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DUSP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA,IDA 8670865
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP6: view

Drugs & Compounds for DUSP6 Gene

(8) Drugs for DUSP6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(8) Additional Compounds for DUSP6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP6: view

Transcripts for DUSP6 Gene

Unigene Clusters for DUSP6 Gene

Dual specificity phosphatase 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: -
SP3:
SP4: - - -
SP5:

Relevant External Links for DUSP6 Gene

GeneLoc Exon Structure for
DUSP6
ECgene alternative splicing isoforms for
DUSP6

Expression for DUSP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP6 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP6 Gene



Protein tissue co-expression partners for DUSP6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP6 Gene:

DUSP6

SOURCE GeneReport for Unigene cluster for DUSP6 Gene:

Hs.298654
genes like me logo Genes that share expression patterns with DUSP6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP6 Gene

Orthologs for DUSP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP6 34 35
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP6 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP6 34 35
  • 94.4 (n)
dog
(Canis familiaris)
Mammalia DUSP6 34 35
  • 93.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP6 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp6 34
  • 91.6 (n)
mouse
(Mus musculus)
Mammalia Dusp6 34 16 35
  • 90.64 (n)
chicken
(Gallus gallus)
Aves MKP3 35
  • 93 (a)
OneToOne
DUSP6 34
  • 85.21 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP6 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp6 34
  • 79.37 (n)
Str.10337 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68682 34
zebrafish
(Danio rerio)
Actinopterygii dusp6 34 35
  • 73.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mkp3 36 35
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea lip-1 36 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5162 35
  • 39 (a)
OneToMany
Species where no ortholog for DUSP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP6 Gene

ENSEMBL:
Gene Tree for DUSP6 (if available)
TreeFam:
Gene Tree for DUSP6 (if available)

Paralogs for DUSP6 Gene

Paralogs for DUSP6 Gene

(13) SIMAP similar genes for DUSP6 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DUSP6: view

Variants for DUSP6 Gene

Sequence variations from dbSNP and Humsavar for DUSP6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs139318648 Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269], other 89,350,881(+) GGTCA(A/C/G)ACTCG intron-variant, reference, missense
rs143946794 Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269], Pathogenic 89,350,860(+) CACTA(C/T)TGGGG intron-variant, reference, missense
rs146089505 Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269], other 89,349,363(+) CCAGC(A/G)TCCTC reference, missense
rs587776978 Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269], Pathogenic 89,351,811(+) CGTGA(A/T)GAGCG reference, missense
rs1059366 -- 89,348,785(-) GAAAA(A/G)AAAAT utr-variant-3-prime

Variation tolerance for DUSP6 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.53; 97.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP6 Gene

Human Gene Mutation Database (HGMD)
DUSP6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUSP6 Gene

Disorders for DUSP6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DUSP6 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 19 with or without anosmia
  • hh19
normosmic congenital hypogonadotropic hypogonadism
  • gonadotropic deficiency
kallmann syndrome
  • familial hypogonadism with anosmia
hypogonadism
- elite association - COSMIC cancer census association via MalaCards
Search DUSP6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DUS6_HUMAN
  • Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) [MIM:615269]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in DUSP6 also have a heterozygous mutation in another HH-associated gene including FGFR1 and SPRY4 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Relevant External Links for DUSP6

Genetic Association Database (GAD)
DUSP6
Human Genome Epidemiology (HuGE) Navigator
DUSP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP6
genes like me logo Genes that share disorders with DUSP6: view

No data available for Genatlas for DUSP6 Gene

Publications for DUSP6 Gene

  1. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A. … Ashworth A. (Genomics 1997) 2 3 22 64
  2. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. (PMID: 8626780) Muda M. … Arkinstall S. (J. Biol. Chem. 1996) 2 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. (PMID: 20097731) Zhang Z. … Halmos B. (Carcinogenesis 2010) 3 22 64

Products for DUSP6 Gene

Sources for DUSP6 Gene

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