Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP5 Gene

protein-coding   GIFtS: 63
GCID: GC10P112247

Dual Specificity Phosphatase 5

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 51 2     Serine/Threonine Specific Protein Phosphatase2
Dual Specificity Protein Phosphatase HVH32 3     VH1-Like Phosphatase 32
HVH32 5     EC 3.1.3.163
DUSP2     EC 3.1.3.483
Dual Specificity Protein Phosphatase 52     VH33

External Ids:    HGNC: 30711   Entrez Gene: 18472   Ensembl: ENSG000001381667   OMIM: 6030695   UniProtKB: Q166903   

Export aliases for DUSP5 gene to outside databases

Previous GC identifers: GC10P111150 GC10P111491 GC10P112388 GC10P111922 GC10P111889 GC10P105887


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP5 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a
variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DUSP5 Gene: 
DUSP5 (dual specificity phosphatase 5) is a protein-coding gene. Diseases associated with DUSP5 include malt lymphoma, and agammaglobulinemia, and among its related super-pathways are MAPK signaling pathway. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS5_HUMAN, Q16690
Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Gene Wiki entry for DUSP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP5 gene promoter:
         SRF   Spz1   p53   SRF (504 AA)   Pax-2   Pax-2a   STAT5A   Egr-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q25

DUSP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P112247:  view genomic region     (about GC identifiers)

Start:
112,257,596 bp from pter      End:
112,271,302 bp from pter
Size:
13,707 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS5_HUMAN, Q16690 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 5  
Size: 384 amino acids; 42047 Da
Subcellular location: Nucleus (Potential)
1 PDB 3D structure from and Proteopedia for DUSP5:
2G6Z (3D)    
Secondary accessions: Q12997 Q5T603

Explore the universe of human proteins at neXtProt for DUSP5: NX_Q16690

Explore proteomics data for DUSP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16690

  • DUSP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUSP5 Protein Expression
    REFSEQ proteins: NP_004410.3  
    ENSEMBL proteins: 
     ENSP00000358596  

    Human Recombinant Protein Products for DUSP5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DUSP5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DUSP5
    GenScript Custom Purified and Recombinant Proteins Services for DUSP5
    Novus Biologicals DUSP5 Protein
    Novus Biologicals DUSP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IBA--

    DUSP5 for ontologies           About GeneDecksing



    DUSP5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DUSP5
    GenScript Custom Superior Antibodies Services for DUSP5
    Novus Biologicals DUSP5 Antibodies
    Abcam antibodies for DUSP5
    Cloud-Clone Corp. Antibodies for DUSP5 
    ThermoFisher Antibodies for DUSP5
    LSBio Antibodies in human, mouse, rat for DUSP5 

    Assay Products for DUSP5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DUSP5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DUSP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DUSP5 
    Cloud-Clone Corp. CLIAs for DUSP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    5/7 InterPro protein domains (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q16690

    ProtoNet protein and cluster: Q16690

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS5_HUMAN, Q16690
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS5_HUMAN, Q16690
    Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP5:
    dual specificity (tyr/thr) phosphatase 5,non receptor,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0016791phosphatase activity ----
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--
         
    DUSP5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DUSP5:
     Decreased focal adhesion (FA)   Increased Akt phosphorylation   Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP5
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP5 (see all 55):
    hsa-miR-199a-3p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-218 hsa-miR-133a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidDUSP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUSP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DUSP5
    Sirion Biotech Customized adenovirus for overexpression of DUSP5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DUSP5 (see all 8)
    OriGene ORF clones in mouse, rat for DUSP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUSP5 (NM_004419)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP5
    Sirion Biotech Customized lentivirus for stable overexpression of DUSP5 
                         Customized lentivirus expression plasmids for stable overexpression of DUSP5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DUSP5
    Search LifeMap BioReagents cell lines for DUSP5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DUSP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Direct p53 effectors
    Direct p53 effectors
    3ATF-2 transcription factor network
    ATF-2 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for DUSP5
        MAPK signaling pathway
    ATF-2 transcription factor network
    Direct p53 effectors


    1         Kegg Pathway  (Kegg details for DUSP5):
        MAPK signaling pathway


    DUSP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for DUSP5 (Q166902, 3 ENSP000003585964) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8277538 MINT-8277173 MINT-8277525 MINT-8277514 I2D: score=3 STRING: ENSP00000215832
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TP53ENSP000002693054STRING: ENSP00000269305
    MAPK10ENSP000003521574STRING: ENSP00000352157
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0001706endoderm formation IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7961985

    DUSP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP5 (DUS5)

    3 HMDB Compounds for DUSP5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for DUSP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 20.4 1 1500714 (1)
    tyrosine 18.9 2 12944906 (1)
    serine 0 3 16676402 (1), 12944906 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP5 / DUS5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP5 gene: 
    NM_004419.3  

    Unigene Cluster for DUSP5:

    Dual specificity phosphatase 5
    Hs.2128  [show with all ESTs]
    Unigene Representative Sequence: NM_004419
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369583(uc001kzd.3) ENST00000468749
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP5
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP5 (see all 55):
    hsa-miR-199a-3p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-218 hsa-miR-133a hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidDUSP5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DUSP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP5
    Clone
    Products:
         
    OriGene clones in human, mouse for DUSP5 (see all 8)
    OriGene ORF clones in mouse, rat for DUSP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUSP5 (NM_004419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP5
    Sirion Biotech Customized lentivirus for stable overexpression of DUSP5 
                         Customized lentivirus expression plasmids for stable overexpression of DUSP5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DUSP5
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP5

    Additional mRNA sequence: 

    AB209823.1 BC062545.1 U15932.2 U16996.1 

    7 DOTS entries:

    DT.216266  DT.97844972  DT.91980288  DT.100820146  DT.100820147  DT.75183700  DT.97782655 

    24/192 AceView cDNA sequences (see all 192):

    BM682654 BF439627 BM048598 CA441667 BQ681013 AI128312 BU161158 R32728 
    AI291582 AA374546 AW069032 BQ879078 BM763897 CB107431 BU502562 BQ680872 
    BU630079 BQ676938 AA464808 F02674 BM768549 AI186188 CA306020 BQ923045 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP5    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -                     
    SP2:                                          


    ECgene alternative splicing isoforms for DUSP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP5 expression in normal human tissues (normalized intensities)      DUSP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTTAGTC
    DUSP5 Expression
    About this image


    DUSP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Thalamus
             Olfactory Bulb   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             visceral organ/lung/right lung   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             clps   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor SK17

    See DUSP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP5

    SOURCE GeneReport for Unigene cluster: Hs.2128
        SABiosciences Expression via Pathway-Focused PCR Array including DUSP5: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DUSP5
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DUSP5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp51 , 5 dual specificity phosphatase 51, 5 90.89(n)1
    93.49(a)1
      19 (47.98 cM)5
    2406721  NM_001085390.11  NP_001078859.11 
     535291095 
    chicken
    (Gallus gallus)
    Aves DUSP51 dual specificity phosphatase 5 73.79(n)
    71.5(a)
      423890  XM_421754.3  XP_421754.2 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP56
    Dual specificity protein phosphatase
    64(a)
    1 ↔ 1
    3(45377966-45393938)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153742 Xenopus laevis transcribed sequence with weak similarity more 77.13(n)    BJ064693.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc86e022 Danio rerio cDNA clone MGC73256 IMAGE4199935, complete more 77.05(n)    BC059592.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lip-16
    Protein LIP-1
    25(a)
    1 → many
    IV(6842964-6844966)


    ENSEMBL Gene Tree for DUSP5 (if available)
    TreeFam Gene Tree for DUSP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP5 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP62  DUSP142  DUSP282  DUSP82  
    DUSP72  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    6 SIMAP similar genes for DUSP5 using alignment to 1 protein entry:     DUS5_HUMAN:
    DUSP2    DUSP1    DUSP4    DUSP26    DUSP6    DUSP7

    DUSP5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DUSP5
    PGOHUM00000245243 PGOHUM00000237929


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 SNPs in DUSP5 are shown (see all 387)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887121511,2
    --112255641(+) ATCCAA/TCCCCC 1 -- us2k10--------
    rs1485812161,2
    C--112255660(+) GACCCC/TACCAC 1 -- us2k10--------
    rs1456899491,2
    --112255887(+) GTACGA/CACCAT 1 -- us2k10--------
    rs108849841,2
    C,F,A,H--112255894(+) CCATGC/TTGGGG 1 -- us2k112Minor allele frequency- T:0.25NA EA NS WA 1136
    rs745640251,2
    C,F--112255901(+) GGGGGG/TGTTGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1931698031,2
    --112255907(+) GTTGCA/GTTTTT 1 -- us2k10--------
    rs1477182711,2
    --112255922(+) TTCTTC/TACCCC 1 -- us2k10--------
    rs1409623871,2
    --112255959(+) CCCTCC/GTGCTT 1 -- us2k10--------
    rs1850627021,2
    --112256040(+) CCCACG/TCCCCA 1 -- us2k10--------
    rs1882761771,2
    --112256067(+) CTGGGC/TGCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUSP5 (112257596 - 112271302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DUSP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv467454CNV Gain19166990
    nsv526452CNV Gain19592680
    nsv7211OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DUSP5
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603069    OMIM disorders: --

    18 diseases for DUSP5:    About MalaCards
    malt lymphoma    agammaglobulinemia    mantle cell lymphoma    papillary thyroid carcinoma
    diffuse large b-cell lymphoma    influenza    b-cell lymphomas    kaposi's sarcoma
    graves' disease    burkitt's lymphoma    multiple myeloma    myeloma
    thyroiditis    sarcoma    alzheimer's disease    ovarian cancer
    endotheliitis    breast cancer


    DUSP5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for DUSP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malt lymphoma 40.8 4 16980947 (2)
    lymphoma b-cell 25.5 4 16980947 (2)
    lymphoma 20.7 1 12588443 (1)
    tumors 0 4 16676402 (1), 7719912 (1), 12944906 (1)

    Genetic Association Database (GAD): DUSP5
    Human Genome Epidemiology (HuGE) Navigator: DUSP5 (5 documents)

    Export disorders for DUSP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP5 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with DUSP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. (PubMed id 7836374)1, 2, 9 Kwak S.P. and Dixon J.E. (1995)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase. (PubMed id 17078075)1, 2 Jeong D.G....Kim S.J. (2007)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PubMed id 7806236)1, 3 Martell K.J....Trent J.M. (1994)
    8. A novel dual specificity phosphatase induced by serum stimulation and heat shock. (PubMed id 7961985)1, 2 Ishibashi T.... Aaronson S.A. (1994)
    9. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. (PubMed id 12944906)1, 9 Ueda K....Nakamura Y. (2003)
    10. Dual-specificity MAP kinase phosphatases (MKPs): shapi ng the outcome of MAP kinase signalling. (PubMed id 22812510)1 Caunt C.J. and Keyse S.M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1847 HGNC: 3071 AceView: DUSP5 Ensembl:ENSG00000138166 euGenes: HUgn1847
    ECgene: DUSP5 Kegg: 1847 H-InvDB: DUSP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP5 gene:
    Search GeneIP for patents involving DUSP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DUSP5  
     OriGene qPCR primer pairs and template standards for DUSP5   OriGene Protein Over-expression Lysate for DUSP5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DUSP5  
     OriGene qSTAR qPCR primer pairs in human, mouse for DUSP5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DUSP5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DUSP5   OriGene Custom Protein Services for DUSP5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP5
     QIAGEN SeqTarget long-range PCR primers for resequencing DUSP5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP5
     GenScript Custom Purified and Recombinant Proteins Services for DUSP5 GenScript cDNA clones with any tag delivered in your preferred vector for DUSP5
     GenScript Custom Assay Services for DUSP5 GenScript Custom Superior Antibodies Services for DUSP5
     GenScript Custom overexpressing Cell Line Services for DUSP5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DUSP5 promoter
     Search Chromatin IP Primers for DUSP5
     RT2 qPCR Primer Assay in human, mouse, rat DUSP5
     GNC Network for DUSP5
     SABiosciences PCR Arrays including human, mouse, rat DUSP5
     Search Tocris compounds for DUSP5 (DUS5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DUSP5 antibodies
     DUSP5 proteins
     DUSP5 lysates
     Antibodies for DUSP5
     See all of Abcam's Antibodies, Kits and Proteins for DUSP5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DUSP5
     Antibodies for DUSP5
     ELISAs for DUSP5
     CLIAs for DUSP5
     Search LifeMap BioReagents cell lines for DUSP5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP5
     SwitchGear 3'UTR luciferase reporter plasmids for DUSP5
     SwitchGear Promoter luciferase reporter plasmids for DUSP5
     ThermoFisher Antibodies for DUSP5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP5
    Customized:
     lentivirus for stable overexpression of DUSP5
     lentivirus expression plasmids for stable overexpression of DUSP5
     adenovirus for overexpression of DUSP5
     LSBio Antibodies in human, mouse, rat for DUSP5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DUSP5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4