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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DUSP5 Gene

protein-coding GIFtS: 61
GCID: GC10P112247

dual specificity phosphatase 5

Explore 21 diseases affiliated with
DUSP5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 5¹ ²		Serine/Threonine Specific Protein Phosphatase²
HVH3¹ ² ⁵		VH1-Like Phosphatase 3²
Dual Specificity Protein Phosphatase HVH3² ³		EC 3.1.3.16³
DUSP²		EC 3.1.3.48³
Dual Specificity Protein Phosphatase 5²		VH3³

External Ids:	HGNC: 3071¹	Entrez Gene: 1847²	Ensembl: ENSG00000138166⁷	OMIM: 603069⁵	UniProtKB: Q16690³

Export aliases for DUSP5 gene to outside databases

Previous GC identifers: GC10P111150 GC10P111491 GC10P112388 GC10P111922 GC10P111889 GC10P105887

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP5:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases

inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),

which are associated with cellular proliferation and differentiation. Different members of the family of dual

specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution

and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This

gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and

is localized in the nucleus. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUS5_HUMAN, Q16690

Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Gene Wiki entry for DUSP5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DUSP5 gene promoter:
SRF Spz1 p53 SRF (504 AA) Pax-2 Pax-2a STAT5A Egr-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DUSP5 promoter sequence

Search SABiosciences Chromatin IP Primers for DUSP5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25

DUSP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP5 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P112247: view genomic region (about GC identifiers)

Start:	112,257,596 bp from pter	End:	112,271,302 bp from pter
Size:	13,707 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS5_HUMAN, Q16690 (See protein sequence)

Recommended Name: Dual specificity protein phosphatase 5

Size: 384 amino acids; 42047 Da

Subcellular location: Nucleus (Potential)

1 PDB 3D structure from and Proteopedia for DUSP5:

2G6Z (3D)

Secondary accessions: Q12997 Q5T603

Explore the universe of human proteins at neXtProt for DUSP5: NX_Q16690

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16690

DUSP5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004410.3

ENSEMBL proteins:

ENSP00000358596

Human Recombinant Protein Products for DUSP5:

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	Uscn Proteins for DUSP5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	IBA	--

DUSP5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DUSP5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DUSP5 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR001763 Rhodanese-like_dom

IPR000387 Tyr/Dual-sp_Pase

IPR020422 Dual-sp_phosphatase_subgr_cat

IPR016130 Tyr_Pase_AS

IPR024950 DUSP

Graphical View of Domain Structure for InterPro Entry Q16690

ProtoNet protein and cluster: Q16690

2 Blocks protein families:

IPB000340 Dual specificity protein phosphatase

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: DUS5_HUMAN, Q16690

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily

Similarity: Contains 1 rhodanese domain

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DUS5_HUMAN, Q16690

Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Genatlas biochemistry entry for DUSP5:

dual specificity (tyr/thr) phosphatase 5,non receptor,involved in signal transduction

Enzyme Numbers (IUBMB): EC 3.1.3.16¹ EC 3.1.3.48¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IEA	--
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA	--

DUSP5 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for DUSP5:

Decreased focal adhesion (FA)

Increased Akt phosphorylation

Increased apoptosis

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DUSP5

miRNA Products:		OriGene 3'-UTR Clone: DUSP5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP5
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP5 (see all 55):
		hsa-miR-199a-3p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-218 hsa-miR-133a hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: DUSP5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP5 (see all 6) OriGene siRNA: DUSP5
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DUSP5
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MAPK signaling pathway

MAPK signaling pathway

1.00

MAPK signaling pathway

0.50

ATF-2 transcription factor network

ATF-2 transcription factor network

1.00

Direct p53 effectors

Direct p53 effectors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for DUSP5

	MAPK signaling pathway
	Direct p53 effectors
	ATF-2 transcription factor network

1 Kegg Pathway (Kegg details for DUSP5):

MAPK signaling pathway

DUSP5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DUSP5

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for DUSP5 (Q16690^{2, 3} ENSP00000358596⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK1	P28482²^,³, ENSP00000215832⁴	MINT-8277538 MINT-8277173 MINT-8277525 MINT-8277514 I2D: score=3 STRING: ENSP00000215832
MAPK3	P27361³, ENSP00000263025⁴	I2D: score=3 STRING: ENSP00000263025
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
TP53	ENSP00000269305⁴	STRING: ENSP00000269305
MAPK10	ENSP00000352157⁴	STRING: ENSP00000352157

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000188	inactivation of MAPK activity	IBA	--
GO:0001706	endoderm formation	IBA	--
GO:0006470	protein dephosphorylation	IBA	--
GO:0035335	peptidyl-tyrosine dephosphorylation	TAS	7961985
GO:0045892	negative regulation of transcription, DNA-dependent	--	--

DUSP5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DUSP5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUSP5

3 HMDB Compounds for DUSP5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 Novoseek chemical compound relationships for DUSP5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oligonucleotide	20.4	1	1500714 (1)
tyrosine	18.9	2	12944906 (1)
serine	0	3	16676402 (1), 12944906 (1)

Search CenterWatch for drugs/clinical trials and news about DUSP5 / DUS5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUSP5 gene:

NM_004419.3

Unigene Cluster for DUSP5:

Dual specificity phosphatase 5

Hs.2128 [show with all ESTs]

Unigene Representative Sequence: NM_004419

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369583(uc001kzd.3) ENST00000476681 ENST00000468749

miRNA Products:		OriGene 3'-UTR Clone: DUSP5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP5
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP5 (see all 55):
		hsa-miR-199a-3p hsa-miR-25 hsa-miR-128 hsa-miR-16-1* hsa-miR-624* hsa-miR-218 hsa-miR-133a hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: DUSP5 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP5

Additional cDNA sequence:

AB209823.1 BC062545.1 U15932.2 U16996.1

7 DOTS entries:

DT.216266 DT.97844972 DT.91980288 DT.100820146 DT.100820147 DT.75183700 DT.97782655

24/192 AceView cDNA sequences (see all 192):

AA448504 AA464808 BU502562 BQ684536 BQ676938 AA374546 AI128312 AA431895

BM763897 AI291582 BM048598 AA625715 BU161158 BQ575224 AW069032 AI891152

BQ920614 AI151380 BQ678847 BQ942158 BM768549 BU538034 BM682654 AI198464

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP5 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b
SP1:							-
SP2:

ECgene alternative splicing isoforms for DUSP5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUSP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTTAGTC

About this image

DUSP5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See DUSP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP5

SOURCE GeneReport for Unigene cluster: Hs.2128

SABiosciences Expression via Pathway-Focused PCR Array including DUSP5:

Protein Phosphatases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP5 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DUSP5¹	dual specificity phosphatase 5	73.79(n) 71.5(a)		423890 XM_421754.3 XP_421754.2
lizard (Anolis carolinensis)	Reptilia	DUSP5⁶	--	66(a)	1 ↔ 1	3(45378281-45391715)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15374²	Xenopus laevis transcribed sequence with weak similarity more	77.13(n)		BJ064693.1
zebrafish (Danio rerio)	Actinopterygii	wufc86e02²	Danio rerio cDNA clone MGC73256 IMAGE4199935, complete more	77.05(n)		BC059592.1
thale cress (Arabidopsis thaliana)	eudicotyledons	DSPTP1E⁶	protein-tyrosine-phosphatase IBR5	21(a)	possible ortholog	2(1588360-1590166)
rice (Oryza sativa)	Liliopsida	-- --	dual specificity protein phosphatase, putative, ex... dual specificity protein phosphatase, putative, ex...	18(a) 17(a)	possible ortholog possible ortholog	2(29876197-29879380) 6(11683181-11686916)

ENSEMBL Gene Tree for DUSP5 (if available)
TreeFam Gene Tree for DUSP5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DUSP5 gene

DUSP4² DUSP21² SSH2² DUSP10² DUSP6² SSH3² DUSP16² DUSP19²

DUSP14² DUSP28² DUSP9² DUSP2² DUSP8² DUSP18² DUSP1² SSH1²

DUSP7²

6 SIMAP similar genes for DUSP5 using alignment to 1 protein entry: DUS5_HUMAN:

DUSP2 DUSP1 DUSP4 DUSP26 DUSP6 DUSP7

DUSP5 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for DUSP5
PGOHUM00000245243 PGOHUM00000237929

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188712151^1,2		--	112255641(+)	`ATCCAA/TCCCCC`	1	--	us2k¹		0	--	--	--	--
rs148581216^1,2		--	112255660(+)	`GACCCC/TACCAC`	1	--	us2k¹		0	--	--	--	--
rs145689949^1,2		--	112255887(+)	`GTACGA/CACCAT`	1	--	us2k¹		0	--	--	--	--
rs10884984^1,2	C,F,A,H	--	112255894(+)	`CCATGC/TTGGGG`	1	--	us2k¹		12		NA EA NS WA	1136
rs74564025^1,2	C,F	--	112255901(+)	`GGGGGG/TGTTGC`	1	--	us2k¹		1		WA	118
rs193169803^1,2		--	112255907(+)	`GTTGCA/GTTTTT`	1	--	us2k¹		0	--	--	--	--
rs147718271^1,2		--	112255922(+)	`TTCTTC/TACCCC`	1	--	us2k¹		0	--	--	--	--
rs140962387^1,2		--	112255959(+)	`CCCTCC/GTGCTT`	1	--	us2k¹		0	--	--	--	--
rs185062702^1,2		--	112256040(+)	`CCCACG/TCCCCA`	1	--	us2k¹		0	--	--	--	--
rs188276177^1,2		--	112256067(+)	`CTGGGC/TGCTCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DUSP5 (112257596 - 112271302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DUSP5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP5

DNA2.0 Custom Variant and Variant Library Synthesis for DUSP5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DUSP5 for disorders           About GeneDecksing

OMIM gene information: 603069    OMIM disorders: --

20/21 diseases for DUSP5 (see all 21):    About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas malt lymphoma haemophilus influenzae

mantle cell lymphoma papillary thyroid carcinoma burkitt's lymphoma kaposi's sarcoma

agammaglobulinemia graves' disease multiple myeloma thyroid carcinoma

influenza myeloma thyroiditis sarcoma

colon carcinoma alzheimer's disease ovarian cancer carcinoma

4 Novoseek disease relationships for DUSP5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malt lymphoma	40.8	4	16980947 (2)
lymphoma b-cell	25.5	4	16980947 (2)
lymphoma	20.7	1	12588443 (1)
tumors	0	4	16676402 (1), 7719912 (1), 12944906 (1)

Human Genome Epidemiology (HuGE) Navigator: DUSP5 (5 documents)

Export disorders for DUSP5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DUSP5 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with DUSP5)

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Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. (PubMed id 7836374)^{1, 2, 9} Kwak S.P. and Dixon J.E. (1995)
Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase. (PubMed id 17078075)^{1, 2} Jeong D.G....Kim S.J. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PubMed id 7806236)^{1, 3} Martell K.J....Trent J.M. (1994)
A novel dual specificity phosphatase induced by serum stimulation and heat shock. (PubMed id 7961985)^{1, 2} Ishibashi T.... Aaronson S.A. (1994)
Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. (PubMed id 12944906)^{1, 9} Ueda K....Nakamura Y. (2003)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth a rrest versus proliferation response of MCF-7 breast cancer cells to phorbol est er. (PubMed id 20554528)¹ Nunes-Xavier C.E....Pulido R. (2010)
DUSP5 and DUSP6 modulate corneal epithelial cell prol iferation. (PubMed id 20806045)¹ Wang Z....Wolosin J.M. (2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)¹ Johnatty S.E.... . (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1847	HGNC: 3071	AceView: DUSP5	Ensembl:ENSG00000138166	euGenes: HUgn1847
ECgene: DUSP5	Kegg: 1847	H-InvDB: DUSP5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DUSP5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DUSP5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DUSP5 gene
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Patent Information for DUSP5 gene:
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