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Aliases for DUSP5 Gene

Aliases for DUSP5 Gene

  • Dual Specificity Phosphatase 5 2 3 5
  • Dual Specificity Protein Phosphatase HVH3 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • VH1-Like Phosphatase 3 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP 3
  • HVH3 3
  • VH3 4

External Ids for DUSP5 Gene

Previous GeneCards Identifiers for DUSP5 Gene

  • GC10P111150
  • GC10P111491
  • GC10P112388
  • GC10P111922
  • GC10P111889
  • GC10P112247
  • GC10P105887

Summaries for DUSP5 Gene

Entrez Gene Summary for DUSP5 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP5 Gene

DUSP5 (Dual Specificity Phosphatase 5) is a Protein Coding gene. Diseases associated with DUSP5 include lymphoma, malt, somatic and mantle cell lymphoma. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP5 Gene

  • Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.

Gene Wiki entry for DUSP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP5 Gene

Genomics for DUSP5 Gene

Regulatory Elements for DUSP5 Gene

Promoters for DUSP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP5 Gene

Chromosome:
10
Start:
110,497,838 bp from pter
End:
110,511,544 bp from pter
Size:
13,707 bases
Orientation:
Plus strand

Genomic View for DUSP5 Gene

Genes around DUSP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP5 Gene

Proteins for DUSP5 Gene

  • Protein details for DUSP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16690-DUS5_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 5
    Protein Accession:
    Q16690
    Secondary Accessions:
    • Q12997
    • Q5T603

    Protein attributes for DUSP5 Gene

    Size:
    384 amino acids
    Molecular mass:
    42047 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP5 Gene

neXtProt entry for DUSP5 Gene

Proteomics data for DUSP5 Gene at MOPED

Post-translational modifications for DUSP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DUSP5 Gene

Domains & Families for DUSP5 Gene

Gene Families for DUSP5 Gene

Suggested Antigen Peptide Sequences for DUSP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16690

UniProtKB/Swiss-Prot:

DUS5_HUMAN :
  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP5: view

Function for DUSP5 Gene

Molecular function for DUSP5 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 5,non receptor,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.

Enzyme Numbers (IUBMB) for DUSP5 Gene

Gene Ontology (GO) - Molecular Function for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP5: view
genes like me logo Genes that share phenotypes with DUSP5: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP5 Gene

Localization for DUSP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP5 Gene COMPARTMENTS Subcellular localization image for DUSP5 gene
Compartment Confidence
nucleus 5
cytosol 3
chloroplast 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP5 Gene

Pathways & Interactions for DUSP5 Gene

SuperPathways for DUSP5 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP5: view

Pathways by source for DUSP5 Gene

SIGNOR curated interactions for DUSP5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA --
GO:0001706 endoderm formation IBA --
genes like me logo Genes that share ontologies with DUSP5: view

Drugs & Compounds for DUSP5 Gene

(3) Drugs for DUSP5 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(4) Additional Compounds for DUSP5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP5: view

Transcripts for DUSP5 Gene

mRNA/cDNA for DUSP5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP5 Gene

Dual specificity phosphatase 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for DUSP5 Gene

GeneLoc Exon Structure for
DUSP5
ECgene alternative splicing isoforms for
DUSP5

Expression for DUSP5 Gene

mRNA expression in normal human tissues for DUSP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP5 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for DUSP5 Gene

This gene is overexpressed in Plasma (52.4) and Urine (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP5 Gene



SOURCE GeneReport for Unigene cluster for DUSP5 Gene Hs.2128

genes like me logo Genes that share expression patterns with DUSP5: view

Protein tissue co-expression partners for DUSP5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DUSP5 Gene

Orthologs for DUSP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP5 36
  • 81 (a)
OneToOne
DUSP5 35
  • 91.58 (n)
  • 93.23 (a)
dog
(Canis familiaris)
Mammalia DUSP5 35
  • 93.02 (n)
  • 93.46 (a)
DUSP5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp5 36
  • 93 (a)
OneToOne
Dusp5 16
Dusp5 35
  • 90.89 (n)
  • 93.49 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP5 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp5 35
  • 90.36 (n)
  • 92.71 (a)
chicken
(Gallus gallus)
Aves DUSP5 36
  • 69 (a)
OneToOne
DUSP5 35
  • 73.88 (n)
  • 70.98 (a)
lizard
(Anolis carolinensis)
Reptilia DUSP5 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15374 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp5 35
  • 66.22 (n)
  • 61.76 (a)
Str.4744 35
zebrafish
(Danio rerio)
Actinopterygii dusp5 36
  • 55 (a)
OneToOne
dusp5 35
  • 61.6 (n)
  • 56.62 (a)
wufc86e02 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for DUSP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP5 Gene

ENSEMBL:
Gene Tree for DUSP5 (if available)
TreeFam:
Gene Tree for DUSP5 (if available)

Paralogs for DUSP5 Gene

Paralogs for DUSP5 Gene

(6) SIMAP similar genes for DUSP5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DUSP5 Gene

genes like me logo Genes that share paralogs with DUSP5: view

Variants for DUSP5 Gene

Sequence variations from dbSNP and Humsavar for DUSP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2282238 - 110,502,803(-) GCTCT(C/G)TCACT reference, missense
rs35101549 - 110,510,236(-) GGTTG(A/G)GCGTG reference, missense
rs1889566 - 110,507,064(-) GGTCG(C/T)GCAGG reference, missense
rs1889565 - 110,507,065(-) GGGTC(A/G)CGCAG reference, missense
rs1042606 -- 110,510,917(+) AAAGT(A/C)ACCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP5 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv467454 CNV Gain 19166990
nsv526452 CNV Gain 19592680

Variation tolerance for DUSP5 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP5 Gene

HapMap Linkage Disequilibrium report
DUSP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP5 Gene

Disorders for DUSP5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DUSP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma, malt, somatic
  • malt lymphoma
mantle cell lymphoma
  • lymphocytic choriomeningitis
hematologic cancer
  • blood cancer
- elite association - COSMIC cancer census association via MalaCards
Search DUSP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP5

Genetic Association Database (GAD)
DUSP5
Human Genome Epidemiology (HuGE) Navigator
DUSP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP5
genes like me logo Genes that share disorders with DUSP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP5 Gene

Publications for DUSP5 Gene

  1. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. (PMID: 7836374) Kwak S.P. … Dixon J.E. (J. Biol. Chem. 1995) 3 4 23 67
  2. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. (PMID: 12944906) Ueda K. … Nakamura Y. (Oncogene 2003) 3 23
  3. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PMID: 7806236) Martell K.J. … Trent J.M. (Genomics 1994) 2 3
  4. Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins. (PMID: 25519881) Nayak J. … Ramchandran R. (BMC Biochem. 2014) 3
  5. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. (PMID: 23850713) Yang S.K. … Song K. (Gut 2014) 3

Products for DUSP5 Gene

Sources for DUSP5 Gene

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