Aliases for DUSP5 Gene
External Ids for DUSP5 Gene
Previous GeneCards Identifiers for DUSP5 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP5 Gene
DUSP5 (Dual Specificity Phosphatase 5) is a Protein Coding gene. Diseases associated with DUSP5 include lymphoma, malt, somatic and mantle cell lymphoma. Among its related pathways are MAPK signaling pathway and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot for DUSP5 Gene
Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.