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Aliases for DUSP5 Gene

Aliases for DUSP5 Gene

  • Dual Specificity Phosphatase 5 2 3
  • Dual Specificity Protein Phosphatase HVH3 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • VH1-Like Phosphatase 3 3
  • EC 4
  • EC 4
  • DUSP 3
  • HVH3 3
  • VH3 4

External Ids for DUSP5 Gene

Previous GeneCards Identifiers for DUSP5 Gene

  • GC10P111150
  • GC10P111491
  • GC10P112388
  • GC10P111922
  • GC10P111889
  • GC10P112247
  • GC10P105887

Summaries for DUSP5 Gene

Entrez Gene Summary for DUSP5 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP5 Gene

DUSP5 (Dual Specificity Phosphatase 5) is a Protein Coding gene. Diseases associated with DUSP5 include lymphoma, malt, somatic and mantle cell lymphoma. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP5 Gene

  • Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Gene Wiki entry for DUSP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP5 Gene

Genomics for DUSP5 Gene

Regulatory Elements for DUSP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP5 Gene

110,497,838 bp from pter
110,511,544 bp from pter
13,707 bases
Plus strand

Genomic View for DUSP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP5 Gene

Proteins for DUSP5 Gene

  • Protein details for DUSP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 5
    Protein Accession:
    Secondary Accessions:
    • Q12997
    • Q5T603

    Protein attributes for DUSP5 Gene

    384 amino acids
    Molecular mass:
    42047 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP5 Gene

neXtProt entry for DUSP5 Gene

Proteomics data for DUSP5 Gene at MOPED

Post-translational modifications for DUSP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DUSP5 Gene

Domains & Families for DUSP5 Gene

Gene Families for DUSP5 Gene

Suggested Antigen Peptide Sequences for DUSP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP5: view

Function for DUSP5 Gene

Molecular function for DUSP5 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 5,non receptor,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Enzyme Numbers (IUBMB) for DUSP5 Gene

Gene Ontology (GO) - Molecular Function for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15713638
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP5: view
genes like me logo Genes that share phenotypes with DUSP5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP5 Gene

Localization for DUSP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP5 Gene

Subcellular locations from

Jensen Localization Image for DUSP5 Gene COMPARTMENTS Subcellular localization image for DUSP5 gene
Compartment Confidence
nucleus 3
chloroplast 1
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with DUSP5: view

Pathways & Interactions for DUSP5 Gene

SuperPathways for DUSP5 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 MAPK signaling pathway
3 Immune System
4 Signaling by GPCR
5 Developmental Biology
genes like me logo Genes that share pathways with DUSP5: view

Pathways by source for DUSP5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for DUSP5 Gene


Gene Ontology (GO) - Biological Process for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000188 inactivation of MAPK activity IEA --
GO:0001706 endoderm formation IBA --
genes like me logo Genes that share ontologies with DUSP5: view

Drugs & Compounds for DUSP5 Gene

(3) Drugs for DUSP5 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
serine Nutra 420
tyrosine Nutra 547

(4) Additional Compounds for DUSP5 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DUSP5: view

Transcripts for DUSP5 Gene

mRNA/cDNA for DUSP5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP5 Gene

Dual specificity phosphatase 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -

Relevant External Links for DUSP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP5 Gene

mRNA expression in normal human tissues for DUSP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP5 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for DUSP5 Gene

This gene is overexpressed in Plasma (52.4) and Urine (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP5 Gene

SOURCE GeneReport for Unigene cluster for DUSP5 Gene Hs.2128

genes like me logo Genes that share expression patterns with DUSP5: view

Protein tissue co-expression partners for DUSP5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DUSP5 Gene

Orthologs for DUSP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP5 35
  • 91.58 (n)
  • 93.23 (a)
DUSP5 36
  • 81 (a)
(Canis familiaris)
Mammalia DUSP5 35
  • 93.02 (n)
  • 93.46 (a)
DUSP5 36
  • 93 (a)
(Mus musculus)
Mammalia Dusp5 35
  • 90.89 (n)
  • 93.49 (a)
Dusp5 16
Dusp5 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Dusp5 35
  • 90.36 (n)
  • 92.71 (a)
(Monodelphis domestica)
Mammalia DUSP5 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP5 36
  • 77 (a)
(Pan troglodytes)
Mammalia DUSP5 36
  • 100 (a)
(Gallus gallus)
Aves DUSP5 35
  • 73.88 (n)
  • 70.98 (a)
DUSP5 36
  • 69 (a)
(Anolis carolinensis)
Reptilia DUSP5 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp5 35
  • 66.22 (n)
  • 61.76 (a)
Str.4744 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15374 35
(Danio rerio)
Actinopterygii dusp5 35
  • 61.6 (n)
  • 56.62 (a)
wufc86e02 35
dusp5 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for DUSP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP5 Gene

Gene Tree for DUSP5 (if available)
Gene Tree for DUSP5 (if available)

Paralogs for DUSP5 Gene

Paralogs for DUSP5 Gene

(6) SIMAP similar genes for DUSP5 Gene using alignment to 1 proteins: Pseudogenes for DUSP5 Gene

genes like me logo Genes that share paralogs with DUSP5: view

Variants for DUSP5 Gene

Sequence variations from dbSNP and Humsavar for DUSP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs915216 -- 110,511,709(+) GGTTT(C/T)CCTAA downstream-variant-500B
rs1029169 -- 110,500,546(-) CCCCC(A/G)CCAAG intron-variant
rs1042606 -- 110,510,917(+) AAAGT(A/C)ACCCT utr-variant-3-prime
rs1042641 -- 110,511,499(+) TTGTT(C/G)TTGTT utr-variant-3-prime
rs1334944 -- 110,506,288(+) TTAGC(C/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP5 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv467454 CNV Gain 19166990
nsv526452 CNV Gain 19592680

Variation tolerance for DUSP5 Gene

Residual Variation Intolerance Score: 67.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP5 Gene

Disorders for DUSP5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUSP5 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
lymphoma, malt, somatic
  • malt lymphoma
mantle cell lymphoma
  • lymphocytic choriomeningitis
- elite association
Search DUSP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DUSP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP5 Gene

Publications for DUSP5 Gene

  1. Effect of fluid flow-induced shear stress on human mesenchymal stem cells: differential gene expression of IL1B and MAP3K8 in MAPK signaling. (PMID: 19272346) Glossop J.R. … Cartmell S.H. (Gene Expr. Patterns 2009) 23 67
  2. VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. (PMID: 19741200) Bellou S. … Fotsis T. (Am. J. Physiol., Cell Physiol. 2009) 23 67
  3. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. (PMID: 19789336) Kreeger P.K. … Lauffenburger D.A. (Cancer Res. 2009) 23 67
  4. DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5. (PMID: 18280112) Arkell R.S. … Cook S.J. (Cell. Signal. 2008) 23 67
  5. Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference. (PMID: 18024791) Ortega-Paino E. … Borrebaeck C.A. (Blood 2008) 23 67

Products for DUSP5 Gene

Sources for DUSP5 Gene

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