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Aliases for DUSP5 Gene

Aliases for DUSP5 Gene

  • Dual Specificity Phosphatase 5 2 3
  • Dual Specificity Protein Phosphatase HVH3 3 4
  • HVH3 3 6
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 5 3
  • VH1-Like Phosphatase 3 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP 3
  • VH3 4

External Ids for DUSP5 Gene

Summaries for DUSP5 Gene

Entrez Gene Summary for DUSP5 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP5 Gene

DUSP5 (Dual Specificity Phosphatase 5) is a Protein Coding gene. Diseases associated with DUSP5 include malt lymphoma. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP5 Gene

  • Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Gene Wiki entry for DUSP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP5 Gene

Genomics for DUSP5 Gene

Genomic Location for DUSP5 Gene

Start:
110,497,838 bp from pter
End:
110,511,544 bp from pter
Size:
13,707 bases
Orientation:
Plus strand

Genomic View for DUSP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP5 Gene

Regulatory Elements for DUSP5 Gene

Proteins for DUSP5 Gene

  • Protein details for DUSP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16690-DUS5_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 5
    Protein Accession:
    Q16690
    Secondary Accessions:
    • Q12997
    • Q5T603

    Protein attributes for DUSP5 Gene

    Size:
    384 amino acids
    Molecular mass:
    42047 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP5 Gene

neXtProt entry for DUSP5 Gene

Proteomics data for DUSP5 Gene at MOPED

Post-translational modifications for DUSP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP5 Gene

Domains for DUSP5 Gene

Gene Families for DUSP5 Gene

HGNC:
  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

UniProtKB/Swiss-Prot:

DUS5_HUMAN
Domain:
  • Contains 1 rhodanese domain.:
    • Q16690
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q16690
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • Q16690
genes like me logo Genes that share domains with DUSP5: view

Function for DUSP5 Gene

Molecular function for DUSP5 Gene

GENATLAS Biochemistry: dual specificity (tyr/thr) phosphatase 5,non receptor,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1

Enzyme Numbers (IUBMB) for DUSP5 Gene

Gene Ontology (GO) - Molecular Function for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15713638
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP5: view

Phenotypes for DUSP5 Gene

genes like me logo Genes that share phenotypes with DUSP5: view

miRNA for DUSP5 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP5 Gene

Localization for DUSP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP5 Gene COMPARTMENTS Subcellular localization image for DUSP5 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DUSP5: view

Pathways for DUSP5 Gene

genes like me logo Genes that share pathways with DUSP5: view

Pathways by source for DUSP5 Gene

1 KEGG pathway for DUSP5 Gene

Gene Ontology (GO) - Biological Process for DUSP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0001706 endoderm formation IBA --
GO:0006470 protein dephosphorylation IBA --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7961985
genes like me logo Genes that share ontologies with DUSP5: view

Compounds for DUSP5 Gene

(3) HMDB Compounds for DUSP5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(3) Novoseek inferred chemical compound relationships for DUSP5 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 20.4 1
tyrosine 18.9 1
serine 0 2
genes like me logo Genes that share compounds with DUSP5: view

Transcripts for DUSP5 Gene

mRNA/cDNA for DUSP5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP5 Gene

Dual specificity phosphatase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for DUSP5 Gene

GeneLoc Exon Structure for
DUSP5
ECgene alternative splicing isoforms for
DUSP5

Expression for DUSP5 Gene

mRNA expression in normal human tissues for DUSP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP5 Gene

This gene is overexpressed in Esophagus - Mucosa (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP5 Gene

SOURCE GeneReport for Unigene cluster for DUSP5 Gene Hs.2128

genes like me logo Genes that share expressions with DUSP5: view

Orthologs for DUSP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP5 36
  • 91.58 (n)
  • 93.23 (a)
DUSP5 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP5 36
  • 93.02 (n)
  • 93.46 (a)
DUSP5 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp5 36
  • 90.89 (n)
  • 93.49 (a)
Dusp5 16
Dusp5 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP5 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP5 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp5 36
  • 90.36 (n)
  • 92.71 (a)
chicken
(Gallus gallus)
Aves DUSP5 36
  • 73.88 (n)
  • 70.98 (a)
DUSP5 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP5 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15374 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp5 36
  • 66.22 (n)
  • 61.76 (a)
Str.4744 36
zebrafish
(Danio rerio)
Actinopterygii dusp5 36
  • 61.6 (n)
  • 56.62 (a)
dusp5 37
  • 55 (a)
OneToOne
wufc86e02 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for DUSP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP5 Gene

ENSEMBL:
Gene Tree for DUSP5 (if available)
TreeFam:
Gene Tree for DUSP5 (if available)

Paralogs for DUSP5 Gene

Paralogs for DUSP5 Gene

Selected SIMAP similar genes for DUSP5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DUSP5 Gene

genes like me logo Genes that share paralogs with DUSP5: view

Variants for DUSP5 Gene

Sequence variations from dbSNP and Humsavar for DUSP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs915216 -- 110,511,709(+) GGTTT(C/T)CCTAA downstream-variant-500B
rs1029169 -- 110,500,546(-) CCCCC(A/G)CCAAG intron-variant
rs1042606 -- 110,510,917(+) AAAGT(A/C)ACCCT utr-variant-3-prime
rs1042641 -- 110,511,499(+) TTGTT(C/G)TTGTT utr-variant-3-prime
rs1334944 -- 110,506,288(+) TTAGC(C/T)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP5 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv467454 CNV Gain 19166990
nsv526452 CNV Gain 19592680

Relevant External Links for DUSP5 Gene

HapMap Linkage Disequilibrium report
DUSP5

Disorders for DUSP5 Gene

(1) MalaCards Diseases for DUSP5 Gene

Search for DUSP5 Gene in MalaCards »

(4) Novoseek inferred disease relationships for DUSP5 Gene

Disease -log(P) Hits PubMed IDs
malt lymphoma 40.8 2
lymphoma b-cell 25.5 2
lymphoma 20.7 1
tumors 0 3

Relevant External Links for DUSP5

Genetic Association Database (GAD)
DUSP5
Human Genome Epidemiology (HuGE) Navigator
DUSP5
genes like me logo Genes that share disorders with DUSP5: view

No data available for UniProtKB/Swiss-Prot for DUSP5 Gene

Publications for DUSP5 Gene

  1. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. (PMID: 7836374) Kwak S.P. … Dixon J.E. (J. Biol. Chem. 1995) 3 4 23
  2. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. (PMID: 12944906) Ueda K. … Nakamura Y. (Oncogene 2003) 3 23
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  4. Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase. (PMID: 17078075) Jeong D.G. … Kim S.J. (Proteins 2007) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for DUSP5 Gene

  • Addgene plasmids for DUSP5

Sources for DUSP5 Gene

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