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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP4 Gene

protein-coding   GIFtS: 63
GCID: GC08M029190

Dual Specificity Phosphatase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 41 2     HVH22 5
MAP Kinase Phosphatase 21 2 3     TYP2
MKP22 3 5     Dual Specificity Protein Phosphatase 42
VH1 Homologous Phosphatase 21 2     Serine/Threonine Specific Protein Phosphatase2
Dual Specificity Protein Phosphatase HVH22 3     EC 3.1.3.163
Mitogen-Activated Protein Kinase Phosphatase 22 3     EC 3.1.3.483
MKP-22 3     VH23

External Ids:    HGNC: 30701   Entrez Gene: 18462   Ensembl: ENSG000001208757   OMIM: 6027475   UniProtKB: Q131153   

Export aliases for DUSP4 gene to outside databases

Previous GC identifers: GC08M028766 GC08M029698 GC08M029014 GC08M029215 GC08M029249 GC08M027737


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP4 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is
expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript
variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation
sites have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP4 Gene: 
DUSP4 (dual specificity phosphatase 4) is a protein-coding gene. Diseases associated with DUSP4 include inclusion body myositis, and myositis, and among its related super-pathways are MAPK signaling pathway and MAP kinase activation in TLR cascade. GO annotations related to this gene include protein tyrosine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP21.

UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115
Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases
ERK1 and ERK2

Gene Wiki entry for DUSP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP4 gene promoter:
         Nkx3-1 v2   p53   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUSP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12-p11

DUSP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M029190:  view genomic region     (about GC identifiers)

Start:
29,190,579 bp from pter      End:
29,208,267 bp from pter
Size:
17,689 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 4  
Size: 394 amino acids; 42953 Da
Subunit: Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the
basic unit
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for DUSP4:
3EZZ (3D)    
Secondary accessions: B2RBU5 D3DSU4 G5E930 Q13524
Alternative splicing: 2 isoforms:  Q13115-1   Q13115-2   (Does not bind to JNK or ERK, and is more susceptible to proteosomal degradation)

Explore the universe of human proteins at neXtProt for DUSP4: NX_Q13115

Explore proteomics data for DUSP4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13115

  • DUSP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUSP4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001385.1  NP_476499.1  

    ENSEMBL proteins: 
     ENSP00000240100   ENSP00000240101  
    Reactome Protein details: Q13115
    Human Recombinant Protein Products for DUSP4: 
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    Novus Biologicals DUSP4 Protein
    Novus Biologicals DUSP4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DUSP4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7535768
    GO:0005654nucleoplasm TAS--

    DUSP4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    5/7 InterPro protein domains (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q13115

    ProtoNet protein and cluster: Q13115

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS4_HUMAN, Q13115
    Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases
    ERK1 and ERK2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP4:
    dual specificity (tyr/thr) phosphatase 4,vaccinia virus phosphatase VH1-like 2,expressed in
    placenta,pancreas,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0008330protein tyrosine/threonine phosphatase activity TAS7535768
    GO:0016791phosphatase activity ----
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--
         
    DUSP4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP4:
     Decreased focal adhesion (FA)   Increased cell death in HCC-19 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dusp4):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     skeleton 

    DUSP4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DUSP4: Dusp4tm1Plev Dusp4tm1Jmol

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP4 
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    SwitchGear 3'UTR luciferase reporter plasmidDUSP4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DUSP4 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    3ERK/MAPK targets
    ERK/MAPK targets0.88
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    Nuclear Events (kinase and transcription factor activation)0.88
    ERKs are inactivated0.57
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for DUSP4
        Development EGFR signaling pathway
    Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP4
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP4
        Phosphatases
    MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for DUSP4
        Signal transduction Erk Interactions- Inhibition of Erk
    Development EGFR signaling pathway

    2 BioSystems Pathways for DUSP4
        MAPK signaling pathway
    B Cell Receptor Signaling Pathway

    5/28        Reactome Pathways for DUSP4 (see all 28)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade


    1         Kegg Pathway  (Kegg details for DUSP4):
        MAPK signaling pathway


    DUSP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for DUSP4 (Q131152, 3 ENSP000002401004) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRMP1Q141942, 3, ENSP000003216064MINT-8252659 I2D: score=2 STRING: ENSP00000321606
    MAPK1P284822, 3, ENSP000002158324MINT-8217054 I2D: score=2 STRING: ENSP00000215832
    MAPK9P459842, 3, ENSP000003214104MINT-8217432 I2D: score=2 STRING: ENSP00000321410
    MAPK3P273613, ENSP000002630254I2D: score=4 STRING: ENSP00000263025
    GRIN1Q055863, ENSP000003606164I2D: score=3 STRING: ENSP00000360616
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS7535768
    GO:0000188inactivation of MAPK activity IBA--
    GO:0001706endoderm formation IBA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--

    DUSP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP4 (DUS4)

    3 HMDB Compounds for DUSP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 Novoseek inferred chemical compound relationships for DUSP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 80.3 1 7535768 (1)
    ionomycin 34.2 2 11043573 (1), 15477007 (1)
    thapsigargin 31 3 11165042 (1), 11591707 (1)
    tyrosine 28.5 1 10472421 (1)
    gnrh 17.9 14 11165042 (7), 11591707 (4)
    calcium 0 1 11165042 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP4 / DUS4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP4 gene (2 alternative transcripts): 
    NM_001394.6  NM_057158.3  

    Unigene Cluster for DUSP4:

    Dual specificity phosphatase 4
    Hs.417962  [show with all ESTs]
    Unigene Representative Sequence: NM_057158
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240100(uc003xhl.3 uc003xhm.3) ENST00000240101
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP4
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP4

    Additional mRNA sequence: 

    AK314820.1 AL137704.1 BC002671.2 BC012900.1 BC014565.2 S80632.1 U21108.1 U48807.1 

    11 DOTS entries:

    DT.100775062  DT.100775065  DT.214545  DT.100775061  DT.121475292  DT.95199141  DT.121475265  DT.121475285 
    DT.95371208  DT.95371210  DT.95371214 

    24/171 AceView cDNA sequences (see all 171):

    CB529944 CR623380 AA863407 CA306277 AU279727 BC002671 AI952458 AI521644 
    BE856446 AA444049 BE784630 AA682698 BU858055 BG054596 CB988352 AW205712 
    BX106858 NM_057158 BG760517 BU070962 CA391066 AI824439 AL137704 BM458975 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP4 expression in normal human tissues (normalized intensities)      DUSP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAGCAACT
    DUSP4 Expression
    About this image


    DUSP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor EN7
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Human Villous Capillary Endothelial Cells (HVCEC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Zeugopod Periosteum
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus

    See DUSP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP4

    SOURCE GeneReport for Unigene cluster: Hs.417962
        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP4: 
              Protein Phosphatases in human mouse rat
              Diabetes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP4 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp41 , 5 dual specificity phosphatase 41, 5 89.59(n)1
    96.45(a)1
      8 (21.16 cM)5
    3195201  NM_176933.41  NP_795907.11 
     348072975 
    chicken
    (Gallus gallus)
    Aves DUSP41 dual specificity phosphatase 4 81.42(n)
    85.29(a)
      395642  NM_204838.1  NP_990169.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP46
    Dual specificity protein phosphatase
    75(a)
    1 ↔ 1
    GL343257.1(1417070-1435939)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX772297.12   -- 78.46(n)    BX772297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554232 similar to dual specificity phosphatase 4 77.27(n)   394146  BC052477.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lip-16
    Protein LIP-1
    27(a)
    1 → many
    IV(6842964-6844966)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IBR51 protein-tyrosine-phosphatase IBR5 45.47(n)
    37.5(a)
      814997  NM_126486.5  NP_178534.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g07203001 hypothetical protein 42.02(n)
    35.55(a)
      4330549  NM_001054486.1  NP_001047951.1 


    ENSEMBL Gene Tree for DUSP4 (if available)
    TreeFam Gene Tree for DUSP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP4 gene
    DUSP212  SSH22  DUSP102  DUSP62  DUSP142  DUSP282  DUSP82  DUSP72  
    DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    9 SIMAP similar genes for DUSP4 using alignment to 1 protein entry:     DUS4_HUMAN:
    DUSP1    DUSP2    DUSP5    DUSP10    DUSP6    DUSP7
    DUSP8    DUSP16    DUSP9

    DUSP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/443 SNPs in DUSP4 are shown (see all 443)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154320291,2
    C,F--29190157(+) TGAGAC/ACCTAC 2 -- ds50012Minor allele frequency- A:0.10WA NA 238
    rs1160765721,2
    F--29190165(+) TACCTC/TAAAAA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1405662101,2
    C--29190253(+) CAGGAC/GTTCAA 2 -- ds50010--------
    rs1996389871,2
    --29190430(+) AAAAA-/AAAAG 
            
    AAAAG
    2 -- ds50010--------
    rs1504526121,2
    C--29190510(+) CCCAGC/TGGTTC 2 -- ds50010--------
    rs1913264271,2
    --29190572(+) AACCAA/GGCCAG 2 -- ds50010--------
    rs1492185551,2
    --29190661(+) AAAACA/CAAACC 2 -- ut310--------
    rs1831310311,2
    --29190665(+) CAAAAC/TCAAAC 2 -- ut310--------
    rs1400223931,2
    C--29190669(+) CCAAA-/CCAAAA 2 -- ut310--------
    rs1858229561,2
    C--29190671(+) CAAACA/CAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP4 (29190579 - 29208267 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DUSP4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DUSP4
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602747    OMIM disorders: --

    15 diseases for DUSP4:    About MalaCards
    inclusion body myositis    myositis    vaccinia    acute lymphocytic leukemia
    b-cell chronic lymphocytic leukemia    chronic lymphocytic leukemia    pheochromocytoma    acute myeloid leukemia
    myeloid leukemia    schizophrenia    leukemia    endotheliitis
    ovarian cancer    lung cancer    pancreatitis


    DUSP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DUSP4

    Export disorders for DUSP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP4 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with DUSP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. (PubMed id 7535768)1, 2, 3, 9 Guan K.-L. and Butch E. (1995)
    2. Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2. (PubMed id 19843478)1, 2, 9 Cadalbert L.C....Plevin R. (2010)
    3. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3, 9 Smith A....Ashworth A. (1997)
    4. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. (PubMed id 8626452)1, 2, 9 Chu Y.... Kelly K. (1996)
    5. Crystal structure of the catalytic domain of human MK P-2 reveals a 24-mer assembly. (PubMed id 19415758)1, 2, 9 Jeong D.G....Kim S.J. (2009)
    6. Post-translational regulation of mitogen-activated pr otein kinase phosphatase-2 (MKP-2) by ERK. (PubMed id 21084841)1, 2 Peng D.J....Wu G.S. (2010)
    7. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1, 4 Barber M.J....Krauss R.M. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. (PubMed id 11387337)1, 9 Chen P....Liu Y. (2001)
    10. Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase. (PubMed id 16038800)1, 9 Cadalbert L....Plevin R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1846 HGNC: 3070 AceView: DUSP4 Ensembl:ENSG00000120875 euGenes: HUgn1846
    ECgene: DUSP4 Kegg: 1846 H-InvDB: DUSP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP4 gene:
    Search GeneIP for patents involving DUSP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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