Aliases for DUSP4 Gene
External Ids for DUSP4 Gene
Previous GeneCards Identifiers for DUSP4 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP4 Gene
DUSP4 (Dual Specificity Phosphatase 4) is a Protein Coding gene. Diseases associated with DUSP4 include Chronic Laryngitis and Echolalia. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and MAPK targets/ Nuclear events mediated by MAP kinases. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP1.
UniProtKB/Swiss-Prot for DUSP4 Gene
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.