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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP4 Gene

protein-coding   GIFtS: 63
GCID: GC08M029190

dual specificity phosphatase 4
 Explore 14 diseases affiliated with
DUSP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DUSP4    

Aliases
for DUSP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dual Specificity Phosphatase 41 2     MAP Kinase Phosphatase 22 3
MKP-21 2 3     Dual Specificity Protein Phosphatase 42
HVH21 2 5     Serine/Threonine Specific Protein Phosphatase2
MKP22 3 5     VH1 Homologous Phosphatase 22
TYP1 2     EC 3.1.3.163
Dual Specificity Protein Phosphatase HVH22 3     EC 3.1.3.483
Mitogen-Activated Protein Kinase Phosphatase 22 3     VH23

External Ids:    HGNC: 30701   Entrez Gene: 18462   Ensembl: ENSG000001208757   OMIM: 6027475   UniProtKB: Q131153   

Export aliases for DUSP4 gene to outside databases

Previous GC identifers: GC08M028766 GC08M029698 GC08M029014 GC08M029215 GC08M029249 GC08M027737


Summaries
for DUSP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUSP4:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.
They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),
which are associated with cellular proliferation and differentiation. Different members of the family of dual
specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution
and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This
gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In
addition, multiple polyadenylation sites have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115
Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1
and ERK2

Gene Wiki entry for DUSP4


Genomic Views
for DUSP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP4 gene promoter:
         Nkx3-1 v2   p53   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUSP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12-p11   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12-p11

DUSP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M029190:  view genomic region     (about GC identifiers)

Start:
 29,190,581 bp from pter      End:
 29,208,185 bp from pter
Size:
 17,605 bases      Orientation:
 minus strand

Proteins
for DUSP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 4  
Size: 394 amino acids; 42953 Da
Subunit: Hollow spherical complex composed of 24 subunits with pseudooctahedral symmetry, has a tetramer as the basic
unit
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for DUSP4:
3EZZ (3D)    
Secondary accessions: B2RBU5 D3DSU4 G5E930 Q13524
Alternative splicing: 2 isoforms:  Q13115-1   Q13115-2   (Does not bind to JNK or ERK, and is more susceptible to proteosomal degradation)

Explore the universe of human proteins at neXtProt for DUSP4: NX_Q13115

Post-translational modifications:

  • Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13115

    • DUSP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001385.1  NP_476499.1  

    ENSEMBL proteins: 
     ENSP00000240100   ENSP00000240101  
    Reactome Protein details: Q13115
    Human Recombinant Protein Products: 
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    Novus Biologicals DUSP4 Protein
    Novus Biologicals DUSP4 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DUSP4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus TAS7535768
    GO:0005654nucleoplasm TAS--


    DUSP4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DUSP4

    Protein Domains /
    Families
    for DUSP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DUSP4 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q13115

    ProtoNet protein and cluster: Q13115

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for DUSP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DUS4_HUMAN, Q13115
    Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1
    and ERK2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Genatlas biochemistry entry for DUSP4:
    dual specificity (tyr/thr) phosphatase 4,vaccinia virus phosphatase VH1-like 2,expressed in placenta,pancreas,involved
    in signal transduction

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

    miRNA
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    hsa-miR-642a hsa-let-7d hsa-miR-4305 hsa-miR-105 hsa-miR-4314 hsa-let-7g hsa-let-7a hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP4 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008330protein tyrosine/threonine phosphatase activity TAS7535768
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--


    DUSP4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DUSP4:
     Decreased focal adhesion (FA)   Increased cell death in HCC-19 

    Animal Models:
         Mouse knock-outs for DUSP4: Dusp4tm1Plev Dusp4tm1Jmol
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dusp4):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     skeleton 

    DUSP4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DUSP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2ERK/MAPK targets
    		ERK/MAPK targets1.00
    		MAPK targets/ Nuclear events mediated by MAP kinases0.70
    		Nuclear Events (kinase and transcription factor activation)0.88
    		ERKs are inactivated0.57
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    4Signal transduction Erk Interactions: Inhibition of Erk
    		Signal transduction Erk Interactions: Inhibition of Erk1.00
    		Signal transduction_Erk Interactions- Inhibition of Erk0.92
    5Development EGFR signaling pathway
    		Development EGFR signaling pathway1.00
    		Development_EGFR signaling pathway0.87

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for DUSP4
        Development EGFR signaling pathway
    Signal transduction Erk Interactions- Inhibition of Erk

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DUSP4
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DUSP4
        Phosphatases
    MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for DUSP4
        Signal transduction Erk Interactions- Inhibition of Erk
    Development EGFR signaling pathway

    2 BioSystems Pathways for DUSP4 
        MAPK signaling pathway
    B Cell Receptor Signaling Pathway

    5/28        Reactome Pathways for DUSP4 (see all 28)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade


    1         Kegg Pathway  (Kegg details for DUSP4):
        MAPK signaling pathway


    DUSP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for DUSP4 (Q131152, 3 ENSP000002401004) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRMP1Q141942, 3, ENSP000003216064MINT-8252659 I2D: score=2 STRING: ENSP00000321606
    MAPK1P284822, 3, ENSP000002158324MINT-8217054 I2D: score=2 STRING: ENSP00000215832
    MAPK9P459842, 3, ENSP000003214104MINT-8217432 I2D: score=2 STRING: ENSP00000321410
    MAPK3P273613, ENSP000002630254I2D: score=4 STRING: ENSP00000263025
    GRIN1Q055863, ENSP000003606164I2D: score=3 STRING: ENSP00000360616
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS7535768
    GO:0000188inactivation of MAPK activity IBA--
    GO:0001706endoderm formation IBA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--


    DUSP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUSP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP4

    3 HMDB Compounds for DUSP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    6 Novoseek chemical compound relationships for DUSP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 80.3 1 7535768 (1)
    ionomycin 34.2 2 11043573 (1), 15477007 (1)
    thapsigargin 31 3 11165042 (1), 11591707 (1)
    tyrosine 28.5 1 10472421 (1)
    gnrh 17.9 14 11165042 (7), 11591707 (4)
    calcium 0 1 11165042 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP4 / DUS4 

    Transcripts
    for DUSP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUSP4 gene (2 alternative transcripts): 
    NM_001394.6  NM_057158.3  

    Unigene Cluster for DUSP4:

    Dual specificity phosphatase 4
    Hs.417962  [show with all ESTs]
    Unigene Representative Sequence: NM_057158
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000240100(uc003xhl.3 uc003xhm.3) ENST00000240101

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    hsa-miR-642a hsa-let-7d hsa-miR-4305 hsa-miR-105 hsa-miR-4314 hsa-let-7g hsa-let-7a hsa-miR-155*
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK314820.1 AL137704.1 BC002671.2 BC012900.1 BC014565.2 S80632.1 U21108.1 U48807.1 

    11 DOTS entries:

    DT.100775062  DT.100775065  DT.214545  DT.100775061  DT.121475292  DT.95199141  DT.121475285  DT.95371210 
    DT.121475265  DT.95371208  DT.95371214 

    24/171 AceView cDNA sequences (see all 171):

    AI521644 BE784630 AI339116 AI952458 CR623380 CA306277 AU279727 AA307284 
    BX106858 BE856446 AA863407 BC002671 CB529944 AL137704 AI824439 CB988352 
    BG054596 BG760517 CA391066 NM_057158 BU858055 AA682698 BM837404 AW205712 

    GeneLoc Exon Structure


    Expression
    for DUSP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGAGCAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DUSP4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    BoneZeugopod PeriosteumBone
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Primordial germ cell-like cells (Reconstitution of mo...)

    See DUSP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP4

    SOURCE GeneReport for Unigene cluster: Hs.417962
        SABiosciences Expression via Pathway-Focused PCR Arrays including DUSP4: 
              Protein Phosphatases in human mouse rat
              Diabetes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for DUSP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP4 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DUSP41 dual specificity phosphatase 4 81.42(n)
    85.29(a)    		   395642  NM_204838.1  NP_990169.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DUSP46
    		 --
    		 75(a)
    		 1 ↔ 1
    		 GL343257.1(1418084-1435939)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX772297.12   -- 78.46(n)    BX772297.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc554232 similar to dual specificity phosphatase 4 77.27(n)   394146  BC052477.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons IBR51 protein-tyrosine-phosphatase IBR5 45.47(n)
    37.5(a)    		   814997  NM_126486.5  NP_178534.2 
    rice
    (Oryza sativa)    		 Liliopsida Os02g07203001 hypothetical protein 42.02(n)
    35.55(a)    		   4330549  NM_001054486.1  NP_001047951.1 


    ENSEMBL Gene Tree for DUSP4 (if available)
    TreeFam Gene Tree for DUSP4 (if available) 

    Paralogs
    for DUSP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP4 gene
    DUSP212  SSH22  DUSP102  DUSP62  DUSP192  DUSP142  DUSP282  DUSP82  
    DUSP72  DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  
    DUSP12  
    9 SIMAP similar genes for DUSP4 using alignment to 1 protein entry:     DUS4_HUMAN:
    DUSP1    DUSP2    DUSP5    DUSP10    DUSP6    DUSP7
    DUSP8    DUSP16    DUSP9

    DUSP4 for paralogs           About GeneDecksing



    Genomic Variants
    for DUSP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 NCBI SNPs in DUSP4 are shown (see all 349)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1154320291,2
    		F,--29190157(+) TGAGAC/ACCTAC 2 -- ds50012Minor allele frequency- A:0.10WA NA 238
    rs1160765721,2
    		F,--29190165(+) TACCTC/TAAAAA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1405662101,2
    		--29190253(+) CAGGAC/GTTCAA 2 -- ds50010--------
    rs1996389871,2
    		--29190430(+) AAAAA-/AAAAG 
                AAAAG     		2 -- ds50010--------
    rs1504526121,2
    		--29190510(+) CCCAGC/TGGTTC 2 -- ds50010--------
    rs1913264271,2
    		--29190572(+) AACCAA/GGCCAG 2 -- ds50010--------
    rs1492185551,2
    		--29190661(+) AAAACA/CAAACC 2 -- ut310--------
    rs1831310311,2
    		--29190665(+) CAAAAC/TCAAAC 2 -- ut310--------
    rs1400223931,2
    		C,--29190669(+) CCAAA-/CCAAAA 2 -- ut310--------
    rs1858229561,2
    		--29190671(+) CAAACA/CAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP4 (29190581 - 29208185 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DUSP4: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DUSP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUSP4 for disorders           About GeneDecksing

    OMIM gene information: 602747    OMIM disorders: --

    14 diseases for DUSP4:    About MalaCards
    inclusion body myositis    lymphocytic leukemia    chronic lymphocytic leukemia    acute lymphocytic leukemia
    acute myeloid leukemia    myositis    myeloid leukemia    leukemia
    vaccinia    pheochromocytoma    ovarian cancer    lung cancer
    schizophrenia    pancreatitis


    Export disorders for DUSP4 gene to outside databases

    Publications
    for DUSP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP4 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with DUSP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. (PubMed id 7535768)1, 2, 3, 9 Guan K.-L. and Butch E. (1995)
    2. Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2. (PubMed id 19843478)1, 2, 9 Cadalbert L.C....Plevin R. (2010)
    3. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3, 9 Smith A....Ashworth A. (1997)
    4. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. (PubMed id 8626452)1, 2, 9 Chu Y.... Kelly K. (1996)
    5. Crystal structure of the catalytic domain of human MK P-2 reveals a 24-mer assembly. (PubMed id 19415758)1, 2, 9 Jeong D.G....Kim S.J. (2009)
    6. Post-translational regulation of mitogen-activated pr otein kinase phosphatase-2 (MKP-2) by ERK. (PubMed id 21084841)1, 2 Peng D.J....Wu G.S. (2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. (PubMed id 11387337)1, 9 Chen P....Liu Y. (2001)
    9. Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase. (PubMed id 16038800)1, 9 Cadalbert L....Plevin R. (2005)
    10. Epigenetic downregulation of mitogen-activated protei n kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma c ells. (PubMed id 20124482)1, 9 Waha A....Waha A. (2010)

    External Searches for DUSP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing DUSP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1846 HGNC: 3070 AceView: DUSP4 Ensembl:ENSG00000120875 euGenes: HUgn1846
    ECgene: DUSP4 Kegg: 1846 H-InvDB: DUSP4

    Other Databases showing DUSP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUSP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DUSP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUSP4 gene:
    Search GeneIP for patents involving DUSP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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