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DUSP3 Gene

protein-coding   GIFtS: 69
GCID: GC17M041843

Dual Specificity Phosphatase 3

(Previous name: vaccinia virus phosphatase VH1-related)
(Previous symbol: VHR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 31 2     Dual Specificity Protein Phosphatase 32
VHR1 2 3 5     Serine/Threonine Specific Protein Phosphatase2
Vaccinia Virus Phosphatase VH1-Related1 2     EC 3.1.3.163
Dual Specificity Protein Phosphatase VHR2 3     EC 3.1.3.483
Vaccinia H1-Related Phosphatase2 3     

External Ids:    HGNC: 30691   Entrez Gene: 18452   Ensembl: ENSG000001088617   OMIM: 6001835   UniProtKB: P514523   

Export aliases for DUSP3 gene to outside databases

Previous GC identifers: GC17M041587 GC17M044020 GC17M041856 GC17M042320 GC17M042318 GC17M039199 GC17M037607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP3 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1
locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and
ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to
the conclusion that this gene is not BRCA1. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP3 Gene:
DUSP3 (dual specificity phosphatase 3) is a protein-coding gene. Diseases associated with DUSP3 include byssinosis, and vaccinia. GO annotations related to this gene include MAP kinase phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: DUS3_HUMAN, P51452
Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong
preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2

Gene Wiki entry for DUSP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP3 gene promoter:
         p53   Sp1   MEF-2   MyoD   NF-AT   MEF-2A   NF-AT4   aMEF-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP3 promoter sequence
   Search Chromatin IP Primers for DUSP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21

DUSP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041843:  view genomic region     (about GC identifiers)

Start:
41,843,489 bp from pter      End:
41,856,368 bp from pter
Size:
12,880 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DUS3_HUMAN, P51452 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 3  
Size: 185 amino acids; 20478 Da
Subunit: Interacts with VRK3, which seems to activate it's phosphatase activity (By similarity)
3 PDB 3D structures from and Proteopedia for DUSP3:
1J4X (3D)        1VHR (3D)        3F81 (3D)    
Secondary accessions: D3DX45 Q5U0J1

Explore the universe of human proteins at neXtProt for DUSP3: NX_P51452

Explore proteomics data for DUSP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys53, Lys116
  • Modification sites at PhosphoSitePlus

  • See DUSP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004081.1  
    ENSEMBL proteins: 
     ENSP00000226004   ENSP00000466069   ENSP00000468604   ENSP00000467424   ENSP00000443014  
    Reactome Protein details: P51452

    DUSP3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant DUSP3 Protein
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    Enzo Life Sciences proteins for DUSP3
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    OriGene Protein Over-expression Lysate for DUSP3
    OriGene MassSpec for DUSP3
    OriGene Custom Protein Services for DUSP3
    GenScript Custom Purified and Recombinant Proteins Services for DUSP3
    Novus Biologicals DUSP3 Proteins
    Novus Biologicals DUSP3 Lysates
    Sino Biological Recombinant Protein for DUSP3
    Sino Biological Cell Lysate for DUSP3
    ProSpec Recombinant Protein for DUSP3
    Cloud-Clone Corp. Proteins for DUSP3

    DUSP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DUSP3 (VHR)
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    Novus Biologicals DUSP3 Antibodies
    Abcam antibodies for DUSP3
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    ThermoFisher Antibody for DUSP3
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    DUSP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DUSP3
    Cloud-Clone Corp. CLIAs for DUSP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    Selected InterPro protein domains (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR020417 Atypical_DUSP
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry P51452

    ProtoNet protein and cluster: P51452

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS3_HUMAN, P51452
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS3_HUMAN, P51452
    Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong
    preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Genatlas biochemistry entry for DUSP3:
    dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and
    ovary,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity IDA11863439
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IMP7961745
    GO:0016791phosphatase activity ----
    GO:0033549MAP kinase phosphatase activity IMP16604064
         
    DUSP3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP3:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dusp3):
     adipose tissue  growth/size/body  immune system  limbs/digits/tail  nervous system 
     skeleton 

    DUSP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DUSP3:
    hsa-mir-10a-5p (MIRT025606), hsa-mir-125a-5p (MIRT021310), hsa-mir-361-5p (MIRT020096), hsa-mir-421 (MIRT039365)

    Block miRNA regulation of human, mouse, rat DUSP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP3 (see all 43):
    hsa-miR-3685 hsa-miR-200a hsa-miR-141 hsa-miR-4314 hsa-miR-124 hsa-miR-506 hsa-miR-3065-5p hsa-miR-519e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DUSP3
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DUSP3 (see all 7)
    OriGene ORF clones in mouse, rat for DUSP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DUSP3 (NM_004090)
    Sino Biological Human cDNA Clone for DUSP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS3_HUMAN, P51452: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA12447358
    GO:0005634nucleus IDA16604064
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol IDA12447358

    DUSP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP3 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    ERKs are inactivated0.00
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    4TCR Signaling (Qiagen)
    TCR Signaling0.68
    5ERK Signaling
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DUSP3
        ERK Signaling
    TCR Signaling

    2 Cell Signaling Technology (CST) Pathways for DUSP3
        Phosphatases
    MAP Kinase Signaling

    1 GeneGo (Thomson Reuters) Pathway for DUSP3
        Signal transduction Erk Interactions- Inhibition of Erk


    1 Reactome Pathway for DUSP3
        ERKs are inactivated


    1 Kegg Pathway  (Kegg details for DUSP3):
        MAPK signaling pathway


    DUSP3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP3: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DUSP3 (P514522, 3 ENSP000002260044) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8216514 I2D: score=4 STRING: ENSP00000215832
    MAPK3P273612, 3, ENSP000002630254MINT-8216510 I2D: score=4 STRING: ENSP00000263025
    MAP2K2P365073, ENSP000002629484I2D: score=2 STRING: ENSP00000262948
    PDGFAP040853, ENSP000003465084I2D: score=2 STRING: ENSP00000346508
    STAT1P422243, ENSP000003543944I2D: score=2 STRING: ENSP00000354394
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IMP16604064
    GO:0001701in utero embryonic development IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    DUSP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DUSP3
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP3 (DUS3)

    3 HMDB Compounds for DUSP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    9 Novoseek inferred chemical compound relationships for DUSP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 81 1 8106404 (1)
    phosphothreonine 77.7 1 11863439 (1)
    phosphotyrosine 77 4 8545112 (1), 8106404 (1), 8650541 (1), 11863439 (1)
    phosphoserine 72.4 2 8545112 (1), 8106404 (1)
    tyrosine 58.5 9 8545112 (1), 7829067 (1), 11051099 (1), 17018577 (1) (see all 8)
    threonine 55.3 3 8650541 (1), 9195865 (1), 9548949 (1)
    serine 42.8 3 7829067 (1), 8650541 (1), 9548949 (1)
    cysteine 37.9 4 11051099 (2), 12163160 (1)
    h2o2 4.11 2 11051099 (1), 9548949 (1)



    DUSP3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DUSP3 gene: 
    NM_004090.3  

    Unigene Cluster for DUSP3:

    Dual specificity phosphatase 3
    Hs.181046  [show with all ESTs]
    Unigene Representative Sequence: NM_004090
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226004(uc002ied.4 uc021tya.1 uc002iee.4) ENST00000590753
    ENST00000590935 ENST00000590342 ENST00000591618 ENST00000397937
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DUSP3 (see all 43):
    hsa-miR-3685 hsa-miR-200a hsa-miR-141 hsa-miR-4314 hsa-miR-124 hsa-miR-506 hsa-miR-3065-5p hsa-miR-519e
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    GenScript: all cDNA clones in your preferred vector: DUSP3 (NM_004090)
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    Primer
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    OriGene qPCR primer pairs and template standards for DUSP3
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP3
      QuantiTect SYBR Green Assays in human, mouse, rat DUSP3
      QuantiFast Probe-based Assays in human, mouse, rat DUSP3

    Additional mRNA sequence: 

    AB451424.1 AK055834.1 AK129822.1 AK226170.1 AL049417.1 BC002682.1 BC008286.1 BC035701.1 
    BT019522.1 L05147.1 

    14 DOTS entries:

    DT.100710466  DT.453170  DT.100694611  DT.97797915  DT.100814108  DT.120957706  DT.120957732  DT.100814112 
    DT.100708562  DT.120957720  DT.95171871  DT.100814114  DT.95171875  DT.91655626 

    Selected AceView cDNA sequences (see all 470):

    BM826927 BM550278 AW594187 BM423798 CF994299 BM449728 AL527957 AL555009 
    D11547 BQ189613 BF447331 BM811144 AA642652 CA942048 AA453751 BE671741 
    CF593308 BM553490 BQ717038 BQ669051 AA661628 AI018427 BU539515 AW072452 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DUSP3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b
    SP1:                                -                       -                                             
    SP2:                                -                 -     -                 -     -     -               
    SP3:                                                  -     -                                             
    SP4:                                -                                                                     
    SP5:                                -                 -     -                                             


    ECgene alternative splicing isoforms for DUSP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DUSP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATGGATG
    DUSP3 Expression
    About this image


    DUSP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)
    DUSP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181046
        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP3: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DUSP3
    OriGene qSTAR qPCR primer pairs in human, mouse for DUSP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP3
    QuantiTect SYBR Green Assays in human, mouse, rat DUSP3
    QuantiFast Probe-based Assays in human, mouse, rat DUSP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp31 , 5 dual specificity phosphatase 3 (vaccinia virus phosphatase more1, 5 90.4(n)1
    93.48(a)1
      11 (65.48 cM)5
    723491  NM_028207.31  NP_082483.11 
     1019711435 
    chicken
    (Gallus gallus)
    Aves DUSP31 dual specificity phosphatase 3 72.55(n)
    81.62(a)
      425527  XM_423280.4  XP_423280.4 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP36
    dual specificity phosphatase 3
    75(a)
    1 ↔ 1
    6(78113140-78134114)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004985291 dual specificity protein phosphatase 3-like 65.39(n)
    67.21(a)
      100498529  XM_002937585.2  XP_002937631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp3a1 dual specificity phosphatase 3a 70.39(n)
    71.51(a)
      100000665  XM_001340782.5  XP_001340818.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73786
    --
    31(a)
    1 → many
    X(18794443-18803330)


    ENSEMBL Gene Tree for DUSP3 (if available)
    TreeFam Gene Tree for DUSP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP3 gene
    DUSP262  DUSP212  DUPD12  DUSP132  DUSP272  STYX2  DUSP142  DUSP192  
    DUSP282  DUSP152  DUSP222  DUSP182  
    Selected SIMAP similar genes for DUSP3 using alignment to 6 protein entries:     DUS3_HUMAN (see all proteins) (see all similar genes):
    CALCOCO2    TAF2    RHBG    RBP7    DPP9    SLC24A1
    NLN    RQCD1    TUBA1C    PFKFB3    ZNF429    C14orf105
    COQ5    SNRPF    EEF1E1    FRG1    ZNF114    DUSP13

    DUSP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DUSP3
    PGOHUM00000246682


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP3 (see all 283)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12303961,2
    C,F,A--41843029(+) AGGCAC/ACTACT 1 -- ds500115Minor allele frequency- A:0.30MN NA WA CSA EA 741
    rs1454078381,2
    --41843090(+) AGGCAA/TCTGGG 1 -- ds50010--------
    rs751741991,2
    C--41843128(+) ATTTGA/CAGGAT 1 -- ds50010--------
    rs1492070031,2
    --41843217(+) AAGCAC/TAAACC 1 -- ds50010--------
    rs1140622661,2
    C,F--41843237(+) TCATTC/TAGGAC 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1432445211,2
    --41843336(+) CCATCA/GTGGAA 1 -- ds50010--------
    rs1512400301,2
    --41843360(+) CAGAAC/TGGCTA 1 -- ds50010--------
    rs2009873491,2
    C--41843646(+) CAAAT-/TACCC 
            
    TAAAA
    1 -- ut310--------
    rs1404864441,2
    --41843741(+) CAGGAC/TAAAAC 1 -- ut310--------
    rs767455451,2
    C--41843863(+) CAGTAC/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP3 (41843489 - 41856368 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DUSP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660851CNV Deletion23128226
    nsv908265CNV Gain21882294
    nsv908267CNV Gain21882294

    Human Gene Mutation Database (HGMD): DUSP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DUSP3
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600183    OMIM disorders: --

    8 diseases for DUSP3:    
    About MalaCards
    byssinosis    vaccinia    ovarian cancer    breast cancer
    prostate cancer    lung cancer    prostatitis    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for DUSP3:
    Vaccinia     Byssinosis

    DUSP3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DUSP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 7829067 (1)
    cancer 0 3 18505570 (3)


    Export disorders for DUSP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP3 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with DUSP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PubMed id 10224087)1, 2, 9 Todd J.L.... Denu J.M. (J. Biol. Chem. 1999)
    2. Crystal structure of the dual specificity protein phosphatase VHR. (PubMed id 8650541)1, 2, 9 Yuvaniyama J.... Saper M.A. (Science 1996)
    3. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PubMed id 11863439)1, 2, 9 Schumacher M.A.... Denu J.M. (Biochemistry 2002)
    4. Expression cloning of a human dual-specificity phosphatase. (PubMed id 1281549)1, 2, 9 Ishibashi T.... Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Confirmation of the assignment of the gene encoding Kv1.3, a voltage- gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. (PubMed id 7829094)1, 3 Folander K.... Swanson R. (Genomics 1994)
    7. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. (PubMed id 18505570)1, 9 Henkens R....Rahmouni S. (BMC Cancer 2008)
    8. Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. (PubMed id 7829067)1, 9 Kamb A....Hussey C. (Genomics 1994)
    9. High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. (PubMed id 18311544)1, 9 Wong P.F. and Abubakar S. (amp 2008)
    10. Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes. (PubMed id 23322772)1 Luechapanichkul R....Pei D. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1845 HGNC: 3069 AceView: DUSP3 Ensembl:ENSG00000108861 euGenes: HUgn1845
    ECgene: DUSP3 Kegg: 1845 H-InvDB: DUSP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DUSP3 gene:
    Search GeneIP for patents involving DUSP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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