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Aliases for DUSP3 Gene

Aliases for DUSP3 Gene

  • Dual Specificity Phosphatase 3 2 3 5
  • Dual Specificity Protein Phosphatase VHR 3 4
  • Vaccinia Virus Phosphatase VH1-Related 2 3
  • Vaccinia H1-Related Phosphatase 3 4
  • VHR 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 3 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP3 Gene

Previous HGNC Symbols for DUSP3 Gene

  • VHR

Previous GeneCards Identifiers for DUSP3 Gene

  • GC17M041587
  • GC17M044020
  • GC17M041856
  • GC17M042320
  • GC17M042318
  • GC17M039199
  • GC17M037607
  • GC17M041843

Summaries for DUSP3 Gene

Entrez Gene Summary for DUSP3 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP3 Gene

DUSP3 (Dual Specificity Phosphatase 3) is a Protein Coding gene. Diseases associated with DUSP3 include Vaccinia and Cervix Carcinoma. Among its related pathways are Activated TLR4 signalling and Innate Immune System. GO annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for DUSP3 Gene

  • Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Gene Wiki entry for DUSP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP3 Gene

Genomics for DUSP3 Gene

Regulatory Elements for DUSP3 Gene

Enhancers for DUSP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G043841 1.3 Ensembl ENCODE 10.7 -63.5 -63525 1.2 HNRNPUL1 PKNOX1 ATF1 E2F7 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF263 MPP2 C17orf105 DUSP3 MPP3 CD300LG
GH17G043839 1.2 Ensembl ENCODE 10.9 -61.1 -61147 1.6 MLX AGO1 ARID4B SIN3A ZNF48 ZNF2 YY1 GLIS2 MXD4 MIER2 C17orf105 DUSP3 MPP2 MPP3 MEOX1 CD300LG
GH17G043846 0.9 ENCODE 10.9 -67.6 -67590 0.8 RB1 ARID4B ZNF2 ZNF48 RAD21 SCRT2 ZNF143 EGR2 THAP11 ZNF263 C17orf105 DUSP3 SOST ENSG00000221044 CD300LG MPP3
GH17G043777 1.1 ENCODE 7.6 +0.3 344 2.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ASB16-AS1 ENSG00000267002 DHX8 ENSG00000267340 LINC00910 ENSG00000260793 HMGN1P29 NBR2 DUSP3 SOST
GH17G043773 1.1 Ensembl ENCODE 7.1 +5.9 5918 1.6 ELF3 TBP PKNOX1 FOXA2 ZSCAN9 YY1 ZNF335 CREM THAP11 PPARG MEOX1 MPP3 DUSP3 GC17M043734 SOST
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP3 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094656 300 1401 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9

Genomic Location for DUSP3 Gene

Chromosome:
17
Start:
43,766,121 bp from pter
End:
43,779,000 bp from pter
Size:
12,880 bases
Orientation:
Minus strand

Genomic View for DUSP3 Gene

Genes around DUSP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP3 Gene

Proteins for DUSP3 Gene

  • Protein details for DUSP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51452-DUS3_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 3
    Protein Accession:
    P51452
    Secondary Accessions:
    • D3DX45
    • Q5U0J1
    • Q8IYJ9

    Protein attributes for DUSP3 Gene

    Size:
    185 amino acids
    Molecular mass:
    20478 Da
    Quaternary structure:
    • Interacts with VRK3, which seems to activate its phosphatase activity.

    Three dimensional structures from OCA and Proteopedia for DUSP3 Gene

    Alternative splice isoforms for DUSP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP3 Gene

Post-translational modifications for DUSP3 Gene

  • Ubiquitination at isoforms=253 and Lys116
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DUSP3 (DUSP3)
  • Abcam antibodies for DUSP3

Protein Products

  • Abcam proteins for DUSP3

No data available for DME Specific Peptides for DUSP3 Gene

Domains & Families for DUSP3 Gene

Gene Families for DUSP3 Gene

Suggested Antigen Peptide Sequences for DUSP3 Gene

Graphical View of Domain Structure for InterPro Entry

P51452

UniProtKB/Swiss-Prot:

DUS3_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP3: view

Function for DUSP3 Gene

Molecular function for DUSP3 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 3,vaccinia virus phosphatase VH1 related,expressed in breast and ovary,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Enzyme Numbers (IUBMB) for DUSP3 Gene

Gene Ontology (GO) - Molecular Function for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004725 protein tyrosine phosphatase activity IEA,TAS --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA,IMP 7961745
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA,IEA 24531476
genes like me logo Genes that share ontologies with DUSP3: view
genes like me logo Genes that share phenotypes with DUSP3: view

Animal Models for DUSP3 Gene

MGI Knock Outs for DUSP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP3 Gene

Localization for DUSP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 12447358
GO:0005634 nucleus IEA,IDA 16604064
GO:0005654 nucleoplasm TAS,IDA --
GO:0005829 cytosol IDA 12447358
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DUSP3: view

Pathways & Interactions for DUSP3 Gene

genes like me logo Genes that share pathways with DUSP3: view

Pathways by source for DUSP3 Gene

1 Cell Signaling Technology pathway for DUSP3 Gene
1 KEGG pathway for DUSP3 Gene
1 GeneGo (Thomson Reuters) pathway for DUSP3 Gene
2 Qiagen pathways for DUSP3 Gene

SIGNOR curated interactions for DUSP3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for DUSP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IMP 16604064
GO:0001701 in utero embryonic development IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IDA,IEA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IDA,IEA 7876121
genes like me logo Genes that share ontologies with DUSP3: view

Drugs & Compounds for DUSP3 Gene

(7) Drugs for DUSP3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Nutra 0

(6) Additional Compounds for DUSP3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP3: view

Transcripts for DUSP3 Gene

Unigene Clusters for DUSP3 Gene

Dual specificity phosphatase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DUSP3

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - - - - - - -
SP7: - - - - - - - -

Relevant External Links for DUSP3 Gene

GeneLoc Exon Structure for
DUSP3
ECgene alternative splicing isoforms for
DUSP3

Expression for DUSP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for DUSP3 Gene

This gene is overexpressed in Cardia (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP3 Gene



Protein tissue co-expression partners for DUSP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP3 Gene:

DUSP3

SOURCE GeneReport for Unigene cluster for DUSP3 Gene:

Hs.181046

Evidence on tissue expression from TISSUES for DUSP3 Gene

  • Nervous system(4.8)
  • Intestine(4.3)
  • Lung(3.6)
  • Skin(3.5)
  • Heart(3.2)
  • Muscle(3)
  • Liver(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DUSP3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP3 Gene

Orthologs for DUSP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP3 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia DUSP3 34 35
  • 93.96 (n)
cow
(Bos Taurus)
Mammalia DUSP3 34 35
  • 92.21 (n)
mouse
(Mus musculus)
Mammalia Dusp3 34 16 35
  • 90.4 (n)
rat
(Rattus norvegicus)
Mammalia Dusp3 34
  • 89.86 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP3 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP3 34 35
  • 72.55 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP3 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498529 34
  • 65.39 (n)
zebrafish
(Danio rerio)
Actinopterygii dusp3a 34 35
  • 70.39 (n)
dusp3b 35
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7378 35
  • 31 (a)
OneToMany
Species where no ortholog for DUSP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP3 Gene

ENSEMBL:
Gene Tree for DUSP3 (if available)
TreeFam:
Gene Tree for DUSP3 (if available)

Paralogs for DUSP3 Gene

Pseudogenes.org Pseudogenes for DUSP3 Gene

genes like me logo Genes that share paralogs with DUSP3: view

Variants for DUSP3 Gene

Sequence variations from dbSNP and Humsavar for DUSP3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000405652 -- 43,770,940(+) ATCTT(G/T)TAGTA intron-variant
rs1000566559 -- 43,776,038(+) CACTT(C/G)AACCC intron-variant
rs1000602014 -- 43,778,777(+) CGGGG(C/T)CGGGC intron-variant, upstream-variant-2KB
rs1000737382 -- 43,772,895(+) AGGTC(-/A)AAAAA intron-variant
rs1000887209 -- 43,767,059(+) TTCAG(G/T)GGTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DUSP3 Gene

Variant ID Type Subtype PubMed ID
esv2660851 CNV deletion 23128226
esv3640636 CNV loss 21293372
nsv1060861 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for DUSP3 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP3 Gene

Human Gene Mutation Database (HGMD)
DUSP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP3 Gene

Disorders for DUSP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DUSP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vaccinia
cervix carcinoma
  • cervical cancer
byssinosis
  • cotton mill fever
- elite association - COSMIC cancer census association via MalaCards
Search DUSP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP3
genes like me logo Genes that share disorders with DUSP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP3 Gene

Publications for DUSP3 Gene

  1. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. (PMID: 11863439) Schumacher M.A. … Denu J.M. (Biochemistry 2002) 3 4 22 64
  2. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd J.L. … Denu J.M. (J. Biol. Chem. 1999) 3 4 22 64
  3. Crystal structure of the dual specificity protein phosphatase VHR. (PMID: 8650541) Yuvaniyama J. … Saper M.A. (Science 1996) 3 4 22 64
  4. Expression cloning of a human dual-specificity phosphatase. (PMID: 1281549) Ishibashi T. … Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 22 64
  5. High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. (PMID: 18311544) Wong P.F. … Abubakar S. (Cell. Mol. Biol. Lett. 2008) 3 22 64

Products for DUSP3 Gene

  • Addgene plasmids for DUSP3

Sources for DUSP3 Gene

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