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Aliases for DUSP28 Gene

Aliases for DUSP28 Gene

  • Dual Specificity Phosphatase 28 2 3
  • EC 4
  • EC 4
  • DUSP26 3
  • VHP 3

External Ids for DUSP28 Gene

Previous GeneCards Identifiers for DUSP28 Gene

  • GC02P241149
  • GC02P241499
  • GC02P233255

Summaries for DUSP28 Gene

GeneCards Summary for DUSP28 Gene

DUSP28 (Dual Specificity Phosphatase 28) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP28 Gene

Genomics for DUSP28 Gene

Regulatory Elements for DUSP28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP28 Gene

240,560,054 bp from pter
240,564,014 bp from pter
3,961 bases
Plus strand

Genomic View for DUSP28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP28 Gene

Proteins for DUSP28 Gene

  • Protein details for DUSP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity phosphatase 28
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DUSP28 Gene

    176 amino acids
    Molecular mass:
    18324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP28 Gene

Proteomics data for DUSP28 Gene at MOPED

Post-translational modifications for DUSP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP28 Gene

Domains for DUSP28 Gene

Gene Families for DUSP28 Gene

  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUSP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q4G0W2
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP28: view

Function for DUSP28 Gene

Molecular function for DUSP28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

Enzyme Numbers (IUBMB) for DUSP28 Gene

Gene Ontology (GO) - Molecular Function for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUSP28: view

Phenotypes for DUSP28 Gene

genes like me logo Genes that share phenotypes with DUSP28: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP28

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUSP28 Gene

Localization for DUSP28 Gene

Subcellular locations from

Jensen Localization Image for DUSP28 Gene COMPARTMENTS Subcellular localization image for DUSP28 gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP28 Gene

Pathways for DUSP28 Gene

SuperPathways for DUSP28 Gene

No Data Available

Interacting Proteins for DUSP28 Gene

Gene Ontology (GO) - Biological Process for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA --
GO:0007254 JNK cascade IBA --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP28: view

No data available for Pathways by source for DUSP28 Gene

Compounds for DUSP28 Gene

(1) HMDB Compounds for DUSP28 Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
genes like me logo Genes that share compounds with DUSP28: view

Transcripts for DUSP28 Gene

mRNA/cDNA for DUSP28 Gene

Unigene Clusters for DUSP28 Gene

Dual specificity phosphatase 28:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP28

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP28 Gene

No ASD Table

Relevant External Links for DUSP28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP28 Gene

mRNA expression in normal human tissues for DUSP28 Gene

Protein differential expression in normal tissues for DUSP28 Gene

This gene is overexpressed in Heart (65.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP28 Gene

SOURCE GeneReport for Unigene cluster for DUSP28 Gene Hs.369297

genes like me logo Genes that share expressions with DUSP28: view

Expression partners for DUSP28 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP28 Gene

Orthologs for DUSP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP28 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Dusp28 35
  • 83.54 (n)
  • 82.28 (a)
Dusp28 16
Dusp28 36
  • 82 (a)
(Pan troglodytes)
Mammalia DUSP28 35
  • 99.43 (n)
  • 98.86 (a)
DUSP28 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dusp28 35
  • 83.76 (n)
  • 82.55 (a)
(Monodelphis domestica)
Mammalia DUSP28 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP28 36
  • 62 (a)
(Gallus gallus)
Aves DUSP28 35
  • 66.67 (n)
  • 66.14 (a)
DUSP28 36
  • 55 (a)
(Anolis carolinensis)
Reptilia DUSP28 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp28 35
  • 54.2 (n)
  • 50.36 (a)
(Danio rerio)
Actinopterygii LOC100005205 35
  • 57.49 (n)
  • 53.62 (a)
DUSP28 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15528 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea C04F12.8 36
  • 17 (a)
F13D11.3 36
  • 26 (a)
F26A3.4 36
  • 20 (a)
ZK757.2 36
  • 15 (a)
Species with no ortholog for DUSP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP28 Gene

Gene Tree for DUSP28 (if available)
Gene Tree for DUSP28 (if available)

Paralogs for DUSP28 Gene

Selected SIMAP similar genes for DUSP28 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP28: view

Variants for DUSP28 Gene

Sequence variations from dbSNP and Humsavar for DUSP28 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1128152 -- 240,563,825(+) TTAAA(C/T)GTGTC utr-variant-3-prime
rs4359649 -- 240,564,459(-) TGATG(C/T)GCAGA downstream-variant-500B
rs6710754 -- 240,563,199(+) TCCAC(G/T)GAGCA intron-variant
rs10933616 -- 240,563,482(+) caggc(G/T)tgagc intron-variant
rs12473680 -- 240,563,237(+) gtctc(A/T)ctctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP28 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
essv1993 CNV CNV 17122850
nsv834586 CNV Loss 17160897
nsv10226 CNV Gain 18304495
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876148 CNV Loss 21882294
dgv4474n71 CNV Loss 21882294
dgv4475n71 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv821937 CNV Gain 20364138
nsv876160 CNV Loss 21882294
nsv821938 CNV Gain 20364138
dgv4476n71 CNV Loss 21882294

Relevant External Links for DUSP28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP28 Gene

Disorders for DUSP28 Gene

No disorders were found for DUSP28 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DUSP28 Gene

Publications for DUSP28 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for DUSP28 Gene

Sources for DUSP28 Gene

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