Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUSP28 Gene

Aliases for DUSP28 Gene

  • Dual Specificity Phosphatase 28 2 3 5
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP26 3
  • VHP 3

External Ids for DUSP28 Gene

Previous GeneCards Identifiers for DUSP28 Gene

  • GC02P241149
  • GC02P241499
  • GC02P233255

Summaries for DUSP28 Gene

GeneCards Summary for DUSP28 Gene

DUSP28 (Dual Specificity Phosphatase 28) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP28 Gene

Genomics for DUSP28 Gene

Regulatory Elements for DUSP28 Gene

Enhancers for DUSP28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUSP28 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP28 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP28 Gene

Chromosome:
2
Start:
240,560,054 bp from pter
End:
240,564,014 bp from pter
Size:
3,961 bases
Orientation:
Plus strand

Genomic View for DUSP28 Gene

Genes around DUSP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP28 Gene

Proteins for DUSP28 Gene

  • Protein details for DUSP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0W2-DUS28_HUMAN
    Recommended name:
    Dual specificity phosphatase 28
    Protein Accession:
    Q4G0W2

    Protein attributes for DUSP28 Gene

    Size:
    176 amino acids
    Molecular mass:
    18324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP28 Gene

Proteomics data for DUSP28 Gene at MOPED

Post-translational modifications for DUSP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP28 Gene

Domains & Families for DUSP28 Gene

Gene Families for DUSP28 Gene

Suggested Antigen Peptide Sequences for DUSP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0W2

UniProtKB/Swiss-Prot:

DUS28_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP28: view

Function for DUSP28 Gene

Molecular function for DUSP28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for DUSP28 Gene

Gene Ontology (GO) - Molecular Function for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP28: view
genes like me logo Genes that share phenotypes with DUSP28: view

Animal Model Products

miRNA for DUSP28 Gene

miRTarBase miRNAs that target DUSP28

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP28 Gene

Localization for DUSP28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP28 Gene COMPARTMENTS Subcellular localization image for DUSP28 gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP28 Gene

Pathways & Interactions for DUSP28 Gene

SuperPathways for DUSP28 Gene

No Data Available

Interacting Proteins for DUSP28 Gene

Gene Ontology (GO) - Biological Process for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035335 peptidyl-tyrosine dephosphorylation IBA --
genes like me logo Genes that share ontologies with DUSP28: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP28 Gene

Drugs & Compounds for DUSP28 Gene

(3) Additional Compounds for DUSP28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP28: view

Transcripts for DUSP28 Gene

mRNA/cDNA for DUSP28 Gene

Unigene Clusters for DUSP28 Gene

Dual specificity phosphatase 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP28 Gene

No ASD Table

Relevant External Links for DUSP28 Gene

GeneLoc Exon Structure for
DUSP28
ECgene alternative splicing isoforms for
DUSP28

Expression for DUSP28 Gene

mRNA expression in normal human tissues for DUSP28 Gene

Protein differential expression in normal tissues from HIPED for DUSP28 Gene

This gene is overexpressed in Heart (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP28 Gene



SOURCE GeneReport for Unigene cluster for DUSP28 Gene Hs.369297

genes like me logo Genes that share expression patterns with DUSP28: view

Protein tissue co-expression partners for DUSP28 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP28 Gene

Orthologs for DUSP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP28 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Dusp28 35
  • 83.54 (n)
  • 82.28 (a)
Dusp28 16
Dusp28 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP28 35
  • 99.43 (n)
  • 98.86 (a)
DUSP28 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp28 35
  • 83.76 (n)
  • 82.55 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP28 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP28 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP28 35
  • 66.67 (n)
  • 66.14 (a)
DUSP28 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP28 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp28 35
  • 54.2 (n)
  • 50.36 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005205 35
  • 57.49 (n)
  • 53.62 (a)
DUSP28 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15528 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C04F12.8 36
  • 17 (a)
ManyToMany
F13D11.3 36
  • 26 (a)
ManyToMany
F26A3.4 36
  • 20 (a)
ManyToMany
ZK757.2 36
  • 15 (a)
ManyToMany
Species with no ortholog for DUSP28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP28 Gene

ENSEMBL:
Gene Tree for DUSP28 (if available)
TreeFam:
Gene Tree for DUSP28 (if available)

Paralogs for DUSP28 Gene

(6) SIMAP similar genes for DUSP28 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP28: view

Variants for DUSP28 Gene

Sequence variations from dbSNP and Humsavar for DUSP28 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1128152 -- 240,563,825(+) TTAAA(C/T)GTGTC utr-variant-3-prime
rs4359649 -- 240,564,459(-) TGATG(C/T)GCAGA downstream-variant-500B
rs6710754 -- 240,563,199(+) TCCAC(G/T)GAGCA intron-variant
rs12473680 -- 240,563,237(+) gtctc(A/T)ctctg intron-variant
rs10933616 -- 240,563,482(+) caggc(G/T)tgagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP28 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
essv1993 CNV CNV 17122850
nsv834586 CNV Loss 17160897
nsv10226 CNV Gain 18304495
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876148 CNV Loss 21882294
dgv4474n71 CNV Loss 21882294
dgv4475n71 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv821937 CNV Gain 20364138
nsv876160 CNV Loss 21882294
nsv821938 CNV Gain 20364138
dgv4476n71 CNV Loss 21882294

Variation tolerance for DUSP28 Gene

Gene Damage Index Score: 2.99; 49.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUSP28 Gene

Disorders for DUSP28 Gene

Relevant External Links for DUSP28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP28

No disorders were found for DUSP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP28 Gene

Publications for DUSP28 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling. (PMID: 25230705) Wang D. … Li X. (Int. J. Oncol. 2014) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DUSP28 Gene

Sources for DUSP28 Gene

Content