DUSP28 Gene
protein-coding GIFtS: 45
GCID: GC02P241499
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dual specificity phosphatase 28
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Aliases
for DUSP28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dual Specificity Phosphatase 281 2 | | DUSP261 2 | | VHP1 2 | | EC 3.1.3.163 | | EC 3.1.3.483 |
Export aliases for DUSP28 gene to outside databasesPrevious GC identifers: GC02P241149 GC02P233255 |
Summaries
for DUSP28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DUSP28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DUSP28 gene promoter:
GR GR-beta Cart-1 Hand1 Msx-1 GR-alpha E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUSP28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.1DUSP28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P241499: view genomic region
(about GC identifiers)
Start:
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241,499,471 bp from pter |
End:
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241,503,431 bp from pter |
Size:
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3,961 bases |
Orientation:
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plus strand |
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Proteins
for DUSP28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUS28_HUMAN, Q4G0W2 (See
protein sequence)Recommended Name: Dual specificity phosphatase 28 Size: 176 amino acids; 18324 DaExplore the universe of human proteins at neXtProt for DUSP28: NX_Q4G0W2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G0W2
DUSP28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001028747.1
ENSEMBL proteins: ENSP00000385885 ENSP00000403899 ENSP00000344235
Human Recombinant Protein Products:
DUSP28 Antibody Products:
Assay Products for DUSP28: |
Protein
Domains /
Families
for DUSP28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUSP28 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4G0W2ProtoNet protein and cluster: Q4G0W2 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: DUS28_HUMAN, Q4G0W2Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for DUSP28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUS28_HUMAN, Q4G0W2Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP28 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DUSP28 (NM_001033575) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP28 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP28 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004725 | protein tyrosine phosphatase activity |
IEA | -- | | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
IBA | -- |
DUSP28 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DUSP28:
|
Pathways & Interactions
for DUSP28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP28
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for DUSP28 (ENSP000003442354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035335 | peptidyl-tyrosine dephosphorylation |
IBA | -- |
DUSP28 for ontologies About GeneDecksing
|
Drugs & Compounds
for DUSP28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUSP28
1 HMDB Compound for DUSP28 About this table
Search CenterWatch for drugs/clinical trials and news about DUSP28 / DUS28
|
Transcripts
for DUSP28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUSP28 gene: NM_001033575.1 Unigene Cluster for DUSP28: Dual specificity phosphatase 28 Hs.369297 [show with all ESTs]Unigene Representative Sequence: BC0361985 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000405954(uc002vzh.3) ENST00000438823 ENST00000479788 ENST00000497221
ENST00000343217(uc002vzg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP28 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DUSP28 (NM_001033575) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP28 |
Additional cDNA sequence: BC036198.1 4 DOTS entries: DT.403695 DT.102830111 DT.92419419 DT.311361 24/46 AceView cDNA sequences (see all 46): CA777137 BF111389 AI027213 AI015191 CA776854 AI016945 AI672432 AI695974 AA704879 AW614307 BQ777661 CA941825 CA942006 BC036198 BF981034 AI138344 AI950221 AW206269 AI498377 F25320 AI580677 CB995480 AW452578 AA910001
GeneLoc Exon Structure
|
Expression
for DUSP28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUSP28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATTTATGA
About this image
See DUSP28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP28
SOURCE GeneReport for Unigene cluster: Hs.369297
SABiosciences Custom PCR Arrays for DUSP28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP28
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP28 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP28 |
Orthologs
for DUSP28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DUSP28 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for DUSP28 (if available)
TreeFam Gene Tree for DUSP28 (if available) |
Paralogs
for DUSP28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUSP28 gene
- DUSP42 DUSP212 SSH22 DUSP102 DUSP62 DUSP192 DUSP142 DUSP82
- DUSP72 DUSP52 SSH32 DUSP162 DUSP92 DUSP22 DUSP182 SSH12
- DUSP12
8 SIMAP similar genes for DUSP28 using alignment to 2 protein entries: DUS28_HUMAN (see all proteins):SSH2 SSH1 DUSP14 DUSP22 DUSP18 DUSP9
DUSP10 DUSP21
DUSP28 for paralogs About GeneDecksing
|
Genomic Variants
for DUSP28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DUSP28 (241499471 - 241503431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DUSP28
3 CNVs: 31022 2428 3409 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DUSP28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DUSP28 for disorders About GeneDecksing
3  diseases for DUSP28: About MalaCardsvon willebrand's disease hemophilia hemophilia b
Export disorders for DUSP28 gene to outside databases
|
Publications
for DUSP28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUSP28 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUSP28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DUSP28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DUSP28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUSP28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUSP28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUSP28 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DUSP28 gene:
Search GeneIP for patents involving DUSP28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUSP28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DUSP28 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP28 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP28 | | | OriGene Protein Over-expression Lysate for DUSP28 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for DUSP28 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP28 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP28 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP28 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP28 |
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 | | | DUSP28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP28 |
|  |  |  | | | | Search ThermoFisher Antibodies for DUSP28 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP28 |
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