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Aliases for DUSP28 Gene

Aliases for DUSP28 Gene

  • Dual Specificity Phosphatase 28 2 3 5
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP26 3
  • VHP 3

External Ids for DUSP28 Gene

Previous GeneCards Identifiers for DUSP28 Gene

  • GC02P241149
  • GC02P241499
  • GC02P233255

Summaries for DUSP28 Gene

GeneCards Summary for DUSP28 Gene

DUSP28 (Dual Specificity Phosphatase 28) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP14.

UniProtKB/Swiss-Prot for DUSP28 Gene

  • Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP28 Gene

Genomics for DUSP28 Gene

Regulatory Elements for DUSP28 Gene

Enhancers for DUSP28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F240619 1.7 FANTOM5 Ensembl ENCODE 10.2 +63.8 63847 8.2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 FOS GPR35 DUSP28 CAPN10 LOC285191 PASK AQP12B AQP12A MTERF4 RNPEPL1 LOC100420500
GH02F240556 0.8 ENCODE 5.8 -2.4 -2386 1.7 GTF2F1 CTCF MXI1 PKNOX1 MAX ARID4B SIN3A BMI1 RAD21 POLR2A ANKMY1 DUSP28 PIR41651 PIR62560
GH02F240646 1 FANTOM5 ENCODE 2.2 +86.5 86481 0.5 PKNOX1 ATF1 TARDBP NCOA1 ZBTB33 CREM GABPA LOC285191 DUSP28 GPR35 CAPN10 MTERF4 LOC100420500
GH02F240964 1.2 FANTOM5 Ensembl 1.3 +407.0 406974 5.3 TBP ARID4B DMAP1 THRB ZNF48 ZBTB40 RAD21 THAP11 SP5 ZBTB11 LOC200772 C2orf54 AGXT DUSP28 GC02M240925 CROCC2
GH02F240558 1.1 ENCODE 0.8 +1.3 1268 4.8 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ANKMY1 DUSP28 RNPEPL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP28 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000610740 946 2001 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207

Genomic Location for DUSP28 Gene

Chromosome:
2
Start:
240,560,054 bp from pter
End:
240,564,014 bp from pter
Size:
3,961 bases
Orientation:
Plus strand

Genomic View for DUSP28 Gene

Genes around DUSP28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP28 Gene

Proteins for DUSP28 Gene

  • Protein details for DUSP28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0W2-DUS28_HUMAN
    Recommended name:
    Dual specificity phosphatase 28
    Protein Accession:
    Q4G0W2

    Protein attributes for DUSP28 Gene

    Size:
    176 amino acids
    Molecular mass:
    18324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP28 Gene

Post-translational modifications for DUSP28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP28 Gene

Domains & Families for DUSP28 Gene

Gene Families for DUSP28 Gene

Suggested Antigen Peptide Sequences for DUSP28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0W2

UniProtKB/Swiss-Prot:

DUS28_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP28: view

Function for DUSP28 Gene

Molecular function for DUSP28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).

Enzyme Numbers (IUBMB) for DUSP28 Gene

Gene Ontology (GO) - Molecular Function for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IDA 24531476
genes like me logo Genes that share ontologies with DUSP28: view
genes like me logo Genes that share phenotypes with DUSP28: view

Animal Model Products

miRNA for DUSP28 Gene

miRTarBase miRNAs that target DUSP28

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP28 Gene

Localization for DUSP28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP28 gene
Compartment Confidence
extracellular 2
cytosol 2
plasma membrane 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP28 Gene

Pathways & Interactions for DUSP28 Gene

SuperPathways for DUSP28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IBA --
genes like me logo Genes that share ontologies with DUSP28: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP28 Gene

Drugs & Compounds for DUSP28 Gene

(2) Drugs for DUSP28 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for DUSP28 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DUSP28: view

Transcripts for DUSP28 Gene

mRNA/cDNA for DUSP28 Gene

Unigene Clusters for DUSP28 Gene

Dual specificity phosphatase 28:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP28 Gene

No ASD Table

Relevant External Links for DUSP28 Gene

GeneLoc Exon Structure for
DUSP28
ECgene alternative splicing isoforms for
DUSP28

Expression for DUSP28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP28 Gene

Protein differential expression in normal tissues from HIPED for DUSP28 Gene

This gene is overexpressed in Heart (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP28 Gene



Protein tissue co-expression partners for DUSP28 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP28 Gene:

DUSP28

SOURCE GeneReport for Unigene cluster for DUSP28 Gene:

Hs.369297
genes like me logo Genes that share expression patterns with DUSP28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DUSP28 Gene

Orthologs for DUSP28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP28 34 35
  • 99.43 (n)
rat
(Rattus norvegicus)
Mammalia Dusp28 34
  • 83.76 (n)
mouse
(Mus musculus)
Mammalia Dusp28 34 16 35
  • 83.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP28 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP28 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP28 34 35
  • 66.67 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP28 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp28 34
  • 54.2 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100005205 34
  • 57.49 (n)
DUSP28 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15528 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13D11.3 35
  • 26 (a)
ManyToMany
F26A3.4 35
  • 20 (a)
ManyToMany
C04F12.8 35
  • 17 (a)
ManyToMany
ZK757.2 35
  • 15 (a)
ManyToMany
Species where no ortholog for DUSP28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP28 Gene

ENSEMBL:
Gene Tree for DUSP28 (if available)
TreeFam:
Gene Tree for DUSP28 (if available)

Paralogs for DUSP28 Gene

(6) SIMAP similar genes for DUSP28 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP28: view

Variants for DUSP28 Gene

Sequence variations from dbSNP and Humsavar for DUSP28 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10173382 -- 240,558,166(+) TTACC(C/T)GGTCA intron-variant, upstream-variant-2KB
rs10933615 -- 240,561,091(+) GCCTT(C/T)AGGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10933616 -- 240,563,482(+) caggc(G/T)tgagc intron-variant
rs111241666 -- 240,561,147(+) GGCGG(C/G)GCCGG intron-variant, upstream-variant-2KB
rs111392516 -- 240,559,011(+) GTTGT(C/G)AATTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP28 Gene

Variant ID Type Subtype PubMed ID
esv2759119 CNV gain 17122850
esv3575343 CNV gain 25503493
esv3594802 CNV gain 21293372
nsv1001262 CNV gain 25217958
nsv10226 CNV gain 18304495
nsv821937 CNV gain 20364138
nsv821938 CNV gain 20364138
nsv834586 CNV loss 17160897
nsv955290 CNV deletion 24416366
nsv999050 CNV gain 25217958

Variation tolerance for DUSP28 Gene

Gene Damage Index Score: 2.99; 49.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP28 Gene

Disorders for DUSP28 Gene

Relevant External Links for DUSP28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP28

No disorders were found for DUSP28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP28 Gene

Publications for DUSP28 Gene

  1. The family-wide structure and function of human dual-specificity protein phosphatases. (PMID: 24531476) Jeong D.G. … Ryu S.E. (Acta Crystallogr. D 2014) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Blockade of dual-specificity phosphatase 28 decreases chemo-resistance and migration in human pancreatic cancer cells. (PMID: 26212664) Lee J. … Hoon Kim J. (Sci Rep 2015) 3 64
  4. DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling. (PMID: 25230705) Wang D. … Li X. (Int. J. Oncol. 2014) 3 64
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64

Products for DUSP28 Gene

Sources for DUSP28 Gene

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