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Aliases for DUSP27 Gene

Aliases for DUSP27 Gene

  • Dual Specificity Phosphatase 27 (Putative) 2 3 5

External Ids for DUSP27 Gene

Previous GeneCards Identifiers for DUSP27 Gene

  • GC01P163796
  • GC01P165329
  • GC01P167063
  • GC01P138310

Summaries for DUSP27 Gene

GeneCards Summary for DUSP27 Gene

DUSP27 (Dual Specificity Phosphatase 27 (Putative)) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP13.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP27 Gene

Genomics for DUSP27 Gene

Regulatory Elements for DUSP27 Gene

Enhancers for DUSP27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F167066 1.2 Ensembl ENCODE 12.1 -27.2 -27245 0.8 CBX3 ZFP64 ZNF48 ZNF2 RAD21 ZNF143 MCM3 ZNF654 REST ZEB2 GPA33 DUSP27 POU2F1 ILDR2 MAEL LOC105371600 LOC105371598
GH01F167134 0.8 Ensembl ENCODE 11.7 +42.8 42755 3.6 RING1 ZNF263 PKNOX1 MAX NR3C1 JUND ZNF366 SMARCA4 PBX2 IKZF1 GPA33 DUSP27 LINC01363 GC01P167158
GH01F167120 1.3 Ensembl ENCODE 11.4 +27.7 27727 1.6 CTCF RAD51 POLR2A NRF1 FOXP2 DUSP27 GPA33 LOC105371600 GC01P167158
GH01F167148 0.4 ENCODE 10.7 +54.5 54545 0.6 ZNF316 EMSY DUSP27 GC01P167158
GH01F167165 0.5 Ensembl ENCODE 10.7 +72.6 72613 1.9 TEAD4 MAX FEZF1 ZNF366 POLR2A PRDM10 KLF7 FOS TCF7L2 ZBTB20 LINC01363 DUSP27 GPA33 LOC105371601
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DUSP27 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001751234 155 401
ENSR00001525640 1455 201 HDAC1 ZNF362 RFX1 PKNOX1 BHLHE40 MNT BMI1 ZNF501 ZEB2 ZNF366

Genomic Location for DUSP27 Gene

167,094,045 bp from pter
167,129,897 bp from pter
35,853 bases
Plus strand

Genomic View for DUSP27 Gene

Genes around DUSP27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP27 Gene

Proteins for DUSP27 Gene

  • Protein details for DUSP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive dual specificity phosphatase 27
    Protein Accession:
    Secondary Accessions:
    • A0AUM4
    • Q9C074

    Protein attributes for DUSP27 Gene

    1158 amino acids
    Molecular mass:
    130176 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK02011.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DUSP27 Gene

Post-translational modifications for DUSP27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP27 Gene

No data available for DME Specific Peptides for DUSP27 Gene

Domains & Families for DUSP27 Gene

Suggested Antigen Peptide Sequences for DUSP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP27: view

No data available for Gene Families for DUSP27 Gene

Function for DUSP27 Gene

Gene Ontology (GO) - Molecular Function for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP27: view
genes like me logo Genes that share phenotypes with DUSP27: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP27

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DUSP27 Gene

Localization for DUSP27 Gene

Subcellular locations from

Jensen Localization Image for DUSP27 Gene COMPARTMENTS Subcellular localization image for DUSP27 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP27 Gene

Pathways & Interactions for DUSP27 Gene

SuperPathways for DUSP27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP27: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP27 Gene

Transcripts for DUSP27 Gene

mRNA/cDNA for DUSP27 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP27 Gene

Dual specificity phosphatase 27 (putative):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP27 Gene

No ASD Table

Relevant External Links for DUSP27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DUSP27 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP27 Gene

This gene is overexpressed in Muscle - Skeletal (x22.2), Heart - Left Ventricle (x16.4), and Heart - Atrial Appendage (x11.0).

Protein differential expression in normal tissues from HIPED for DUSP27 Gene

This gene is overexpressed in NK cells (23.6), Fetal heart (15.4), Peripheral blood mononuclear cells (8.7), Fetal testis (7.3), Fetal Liver (6.8), and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP27 Gene

Protein tissue co-expression partners for DUSP27 Gene

NURSA nuclear receptor signaling pathways regulating expression of DUSP27 Gene:


SOURCE GeneReport for Unigene cluster for DUSP27 Gene:

genes like me logo Genes that share expression patterns with DUSP27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DUSP27 Gene

Orthologs for DUSP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DUSP27 35 34
  • 99.05 (n)
(Bos Taurus)
Mammalia DUSP27 34 35
  • 85.87 (n)
(Canis familiaris)
Mammalia DUSP27 34 35
  • 84.9 (n)
(Mus musculus)
Mammalia Dusp27 16 35 34
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Dusp27 34
  • 83.05 (n)
(Monodelphis domestica)
Mammalia DUSP27 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP27 35
  • 68 (a)
(Gallus gallus)
Aves DUSP27 35 34
  • 63.94 (n)
(Anolis carolinensis)
Reptilia DUSP27 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp27 34
  • 58.78 (n)
(Danio rerio)
Actinopterygii LOC792623 34
  • 59.51 (n)
DUSP27 35
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7378 35
  • 37 (a)
Species where no ortholog for DUSP27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP27 Gene

Gene Tree for DUSP27 (if available)
Gene Tree for DUSP27 (if available)

Paralogs for DUSP27 Gene

(4) SIMAP similar genes for DUSP27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP27: view

Variants for DUSP27 Gene

Sequence variations from dbSNP and Humsavar for DUSP27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10127714 -- 167,097,372(+) GACAA(A/C)TCCAT intron-variant
rs10127745 -- 167,097,505(+) GGGTG(G/T)GGAGT intron-variant
rs10127801 -- 167,098,939(+) acaaa(C/T)gtcca intron-variant
rs10494468 -- 167,102,543(+) AAATG(C/G)TGGTT intron-variant
rs10531474 -- 167,124,964(+) AAAAA(-/AA)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP27 Gene

Variant ID Type Subtype PubMed ID
esv2719184 CNV deletion 23290073
esv2750815 CNV gain 17911159
esv3542134 CNV deletion 23714750
nsv1008831 CNV gain 25217958
nsv1078878 OTHER inversion 25765185
nsv1113190 CNV deletion 24896259

Variation tolerance for DUSP27 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.48; 85.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP27 Gene

Disorders for DUSP27 Gene

Relevant External Links for DUSP27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DUSP27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DUSP27 Gene

Publications for DUSP27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PMID: 20520587) Nielsen D.A. … Kreek M.J. (Psychiatr. Genet. 2010) 3 46 64
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  4. Structure of human dual-specificity phosphatase 27 at 2.38 A resolution. (PMID: 21543850) Lountos G.T. … Waugh D.S. (Acta Crystallogr. D 2011) 3 64
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 46 64

Products for DUSP27 Gene

Sources for DUSP27 Gene

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