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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DUSP27 Gene

protein-coding GIFtS: 40
GCID: GC01P167063

dual specificity phosphatase 27 (putative)

Explore 4 diseases affiliated with
DUSP27 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 27 (Putative)¹ ²
Inactive Dual Specificity Phosphatase 27²

External Ids:	HGNC: 25034¹	Entrez Gene: 92235²	Ensembl: ENSG00000198842⁷	UniProtKB: Q5VZP5³

Export aliases for DUSP27 gene to outside databases

Previous GC identifers: GC01P163796 GC01P165329 GC01P138310

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DUSP27 gene promoter:
RFX1 Pbx1a Nkx2-5 HNF-4alpha2 HNF-4alpha1 C/EBPalpha c-Rel Cart-1 c-Myb RSRFC4
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP27

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q24 Ensembl cytogenetic band: 1q24.1 HGNC cytogenetic band: 1q22-q24

DUSP27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP27 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P167063: view genomic region (about GC identifiers)

Start:	167,063,282 bp from pter	End:	167,098,402 bp from pter
Size:	35,121 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: DUS27_HUMAN, Q5VZP5 (See protein sequence)

Recommended Name: Inactive dual specificity phosphatase 27

Size: 1158 amino acids; 130176 Da

Caution: Ser-225 is present instead of the conserved Cys which is expected to be an active site residue suggesting that

this protein has lost its phosphatase activity

Sequence caution: Sequence=AAK02011.1; Type=Erroneous initiation;

Secondary accessions: A0AUM4 Q9C074

Explore the universe of human proteins at neXtProt for DUSP27: NX_Q5VZP5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5VZP5

DUSP27 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073895.1

ENSEMBL proteins:

ENSP00000354483 ENSP00000271385 ENSP00000404874

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DUSP27 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000387 Tyr/Dual-sp_Pase

IPR020422 Dual-sp_phosphatase_subgr_cat

IPR020417 Atypical_DUSP

IPR024950 DUSP

IPR020405 Atypical_DUSP_famA

Graphical View of Domain Structure for InterPro Entry Q5VZP5

ProtoNet protein and cluster: Q5VZP5

1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS27_HUMAN, Q5VZP5

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IBA	--

DUSP27 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DUSP27:

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DUSP27

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein dephosphorylation	IBA	--

DUSP27 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUSP27
Search CenterWatch for drugs/clinical trials and news about DUSP27 / DUS27

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for DUSP27 gene:

NM_001080426.1

Unigene Cluster for DUSP27:

Dual specificity phosphatase 27 (putative)

Hs.632462 [show with all ESTs]

Unigene Representative Sequence: NM_001080426

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361200 ENST00000485151 ENST00000271385 ENST00000443333(uc001geb.1)

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Additional cDNA sequence:

AF119045.1 AK094814.1 BC115387.1

3 DOTS entries:

DT.40113446 DT.91944047 DT.91893589

1 AceView cDNA sequence:

BX503288

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUSP27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See DUSP27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP27

SOURCE GeneReport for Unigene cluster: Hs.632462

SABiosciences Custom PCR Arrays for DUSP27

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP27 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DUSP27¹	dual specificity phosphatase 27 (putative)	64(n) 61.37(a)		418444 XM_416655.3 XP_416655.3
lizard (Anolis carolinensis)	Reptilia	DUSP27⁶	--	58(a)	1 ↔ 1	3(163450312-163456853)
zebrafish (Danio rerio)	Actinopterygii	LOC792623¹	uncharacterized LOC792623	54.38(n) 46.54(a)		792623 XM_003197607.1 XP_003197655.1
fruit fly (Drosophila melanogaster)	Insecta	CG7378⁶	--	31(a)	1 → many	X(18794443-18803330)
thale cress (Arabidopsis thaliana)	eudicotyledons	PHS1⁶	dual specificity protein phosphatase family protei...	6(a)	1 → many	5(7998230-8002840)
rice (Oryza sativa)	Liliopsida	-- --	PHS1, putative, expressed	7(a) 6(a)	many ↔ many many ↔ many	1(13793660-13798880) 1(11692783-11698999)

ENSEMBL Gene Tree for DUSP27 (if available)
TreeFam Gene Tree for DUSP27 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DUSP27 gene

DUSP26² DUPD1² DUSP3² DUSP13²

4 SIMAP similar genes for DUSP27 using alignment to 1 protein entry: DUS27_HUMAN:

DUPD1 DUSP13 DUSP26 DUSP3

DUSP27 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150787300^1,2		--	167062099(+)	`GTGTCC/TCATTC`	1	--	us2k¹		0	--	--	--	--
rs139195350^1,2		--	167062106(+)	`ATTCCC/TCCTAA`	1	--	us2k¹		0	--	--	--	--
rs12042491^1,2	H	--	167062109(+)	`CCTCCT/GAATAA`	1	--	us2k¹		4		NS EA	420
rs149885682^1,2		--	167062129(+)	`TCATTC/GATTCA`	1	--	us2k¹		0	--	--	--	--
rs186775752^1,2		--	167062312(+)	`TGGTAC/TGTGTG`	1	--	us2k¹		0	--	--	--	--
rs3753916^1,2	C,F,H,	--	167062414(+)	`GCTCAT/CGGAAT`	1	--	us2k¹		16		EA NA NS CSA WA	2421
rs3753917^1,2	C,F,H,	--	167062461(+)	`TTGGGG/TTGTGA`	1	--	us2k¹ tfbs³		19		EA NA NS CSA WA	2835
rs6427060^1,2	C,F,H,	--	167062518(+)	`CATCCA/TGAGAC`	1	--	us2k¹		19		NS EA NA WA CSA	975
rs143864540^1,2		--	167062622(+)	`AGGAGA/CTCGAG`	1	--	us2k¹		0	--	--	--	--
rs3753918^1,2	C,F,H,	--	167062644(+)	`CAACAC/TAGTGA`	1	--	us2k¹		6		NA CSA	11

HapMap Linkage Disequilibrium report for DUSP27 (167063282 - 167098402 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DUSP27
1 CNV: 8338

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DUSP27 for disorders About GeneDecksing

4 diseases for DUSP27: About MalaCards

heroin dependence essential hypertension hypertension malaria

Human Genome Epidemiology (HuGE) Navigator: DUSP27 (3 documents)

Export disorders for DUSP27 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DUSP27 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUSP27)

Utopia: connect your pdf to the dynamic
world of online information

Structure of human dual-specificity phosphatase 27 at 2.38 A resolution. (PubMed id 21543850)¹ Lountos G.T.... Waugh D.S. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genome-wide association study identifies genes that m ay contribute to risk for developing heroin addiction. (PubMed id 20520587)¹ Nielsen D.A....Kreek M.J. (2010)
Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)¹ Ehret G.B....Chakravarti A. (2009)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 92235	HGNC: 25034	AceView: LOC92235.1	Ensembl:ENSG00000198842	euGenes: HUgn92235
ECgene: DUSP27	H-InvDB: DUSP27

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DUSP27	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DUSP27 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DUSP27 gene:
Search GeneIP for patents involving DUSP27

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DUSP27 gene at Home site.

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DUSP27 Gene

dual specificity phosphatase 27 (putative)

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Advanced Search

Export list of displayed genes

DUSP27 Gene

dual specificity phosphatase 27 (putative)

Aliasesfor DUSP27 gene

Summariesfor DUSP27 gene

Genomic Viewsfor DUSP27 gene

Proteinsfor DUSP27 gene

Protein Domains /Familiesfor DUSP27 gene

Functionfor DUSP27 gene

Pathways & Interactionsfor DUSP27 gene

Drugs & Compoundsfor DUSP27 gene

Transcriptsfor DUSP27 gene

Expression for DUSP27 gene

Orthologsfor DUSP27 gene

Paralogsfor DUSP27 gene

Genomic Variantsfor DUSP27 gene

Disorders / Diseasesfor DUSP27 gene

Publicationsfor DUSP27 gene

External Searches for DUSP27 gene

Genome Databases showing DUSP27 gene

Other Databases showing DUSP27 gene

Specialized Databases showing DUSP27 gene

Intellectual Propertyfor DUSP27 gene

Productsfor DUSP27 gene

View Random Gene

Aliases
for DUSP27 gene

Summaries
for DUSP27 gene

Genomic Views
for DUSP27 gene

Proteins
for DUSP27 gene

Protein Domains /
Families
for DUSP27 gene

Function
for DUSP27 gene

Pathways & Interactions
for DUSP27 gene

Drugs & Compounds
for DUSP27 gene

Transcripts
for DUSP27 gene

Expression
for DUSP27 gene

Orthologs
for DUSP27 gene

Paralogs
for DUSP27 gene

Genomic Variants
for DUSP27 gene

Disorders / Diseases
for DUSP27 gene

Publications
for DUSP27 gene

Intellectual Property
for DUSP27 gene

Products
for DUSP27 gene