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Aliases for DUSP27 Gene

Aliases for DUSP27 Gene

  • Dual Specificity Phosphatase 27 (Putative) 2 3

External Ids for DUSP27 Gene

Previous GeneCards Identifiers for DUSP27 Gene

  • GC01P163796
  • GC01P165329
  • GC01P138310

Summaries for DUSP27 Gene

GeneCards Summary for DUSP27 Gene

DUSP27 (Dual Specificity Phosphatase 27 (Putative)) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP27 Gene

Genomics for DUSP27 Gene

Regulatory Elements for DUSP27 Gene

Genomic Location for DUSP27 Gene

167,094,045 bp from pter
167,129,165 bp from pter
35,121 bases
Plus strand

Genomic View for DUSP27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP27 Gene

Proteins for DUSP27 Gene

  • Protein details for DUSP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive dual specificity phosphatase 27
    Protein Accession:
    Secondary Accessions:
    • A0AUM4
    • Q9C074

    Protein attributes for DUSP27 Gene

    1158 amino acids
    Molecular mass:
    130176 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK02011.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DUSP27 Gene

Proteomics data for DUSP27 Gene at MOPED

Post-translational modifications for DUSP27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP27 Gene

Domains for DUSP27 Gene

Suggested Antigen Peptide Sequences for DUSP27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VZP5
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP27: view

No data available for Gene Families for DUSP27 Gene

Function for DUSP27 Gene

Gene Ontology (GO) - Molecular Function for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUSP27: view

Phenotypes for DUSP27 Gene

genes like me logo Genes that share phenotypes with DUSP27: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUSP27 Gene

Localization for DUSP27 Gene

Subcellular locations from

Jensen Localization Image for DUSP27 Gene COMPARTMENTS Subcellular localization image for DUSP27 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP27 Gene

Pathways for DUSP27 Gene

SuperPathways for DUSP27 Gene

No Data Available

Interacting Proteins for DUSP27 Gene

Gene Ontology (GO) - Biological Process for DUSP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA --
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with DUSP27: view

No data available for Pathways by source for DUSP27 Gene

Transcripts for DUSP27 Gene

mRNA/cDNA for DUSP27 Gene

(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP27 Gene

Dual specificity phosphatase 27 (putative):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP27 Gene

No ASD Table

Relevant External Links for DUSP27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP27 Gene

mRNA expression in normal human tissues for DUSP27 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP27 Gene

This gene is overexpressed in Muscle - Skeletal (22.2), Heart - Left Ventricle (16.4), and Heart - Atrial Appendage (11.0).

Protein differential expression in normal tissues for DUSP27 Gene

This gene is overexpressed in NK cells (23.6), Fetal heart (15.4), Peripheral blood mononuclear cells (8.7), Fetal testis (7.3), Fetal Liver (6.8), and Heart (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP27 Gene

SOURCE GeneReport for Unigene cluster for DUSP27 Gene Hs.632462

genes like me logo Genes that share expressions with DUSP27: view

Expression partners for DUSP27 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DUSP27 Gene

Orthologs for DUSP27 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP27 35
  • 85.87 (n)
  • 84.59 (a)
DUSP27 36
  • 84 (a)
(Canis familiaris)
Mammalia DUSP27 35
  • 84.9 (n)
  • 82.28 (a)
DUSP27 36
  • 82 (a)
(Mus musculus)
Mammalia Dusp27 35
  • 83.1 (n)
  • 83.07 (a)
Dusp27 16
Dusp27 36
  • 83 (a)
(Pan troglodytes)
Mammalia DUSP27 35
  • 99.05 (n)
  • 98.36 (a)
DUSP27 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dusp27 35
  • 83.05 (n)
  • 82.23 (a)
(Monodelphis domestica)
Mammalia DUSP27 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP27 36
  • 68 (a)
(Gallus gallus)
Aves DUSP27 35
  • 63.94 (n)
  • 61.07 (a)
DUSP27 36
  • 57 (a)
(Anolis carolinensis)
Reptilia DUSP27 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp27 35
  • 58.78 (n)
  • 52.42 (a)
(Danio rerio)
Actinopterygii LOC792623 35
  • 59.51 (n)
  • 53.83 (a)
DUSP27 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7378 36
  • 37 (a)
Species with no ortholog for DUSP27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP27 Gene

Gene Tree for DUSP27 (if available)
Gene Tree for DUSP27 (if available)

Paralogs for DUSP27 Gene

Selected SIMAP similar genes for DUSP27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP27: view

Variants for DUSP27 Gene

Sequence variations from dbSNP and Humsavar for DUSP27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs267741 -- 167,122,622(+) CTCAA(A/G)TCTGA intron-variant
rs267742 -- 167,122,974(+) ACTTT(C/T)CAAAT intron-variant
rs267743 -- 167,123,617(+) CTTTT(A/G)CTTGT intron-variant
rs267744 -- 167,124,966(+) AAAAA(C/T)CCTGA intron-variant
rs267745 - 167,125,926(+) AATGA(C/G)GGCTT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for DUSP27 Gene

Variant ID Type Subtype PubMed ID
esv2750815 CNV Gain 17911159
esv2719184 CNV Deletion 23290073

Relevant External Links for DUSP27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP27 Gene

Disorders for DUSP27 Gene

Relevant External Links for DUSP27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DUSP27 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DUSP27 Gene

Publications for DUSP27 Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PMID: 20520587) Nielsen D.A. … Kreek M.J. (Psychiatr. Genet. 2010) 3 48
  4. Structure of human dual-specificity phosphatase 27 at 2.38 A resolution. (PMID: 21543850) Lountos G.T. … Waugh D.S. (Acta Crystallogr. D 2011) 3
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for DUSP27 Gene

Sources for DUSP27 Gene

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