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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP27 Gene

protein-coding   GIFtS: 42
GCID: GC01P167063

Dual Specificity Phosphatase 27 (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 27 (Putative)1 2
Inactive Dual Specificity Phosphatase 272

External Ids:    HGNC: 250341   Entrez Gene: 922352   Ensembl: ENSG000001988427   UniProtKB: Q5VZP53   

Export aliases for DUSP27 gene to outside databases

Previous GC identifers: GC01P163796 GC01P165329 GC01P138310


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DUSP27 Gene: 
DUSP27 (dual specificity phosphatase 27 (putative)) is a protein-coding gene. Diseases associated with DUSP27 include heroin dependence, and essential hypertension. GO annotations related to this gene include protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP19.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP27 gene promoter:
         RFX1   Pbx1a   Nkx2-5   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   c-Rel   Cart-1   c-Myb   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DUSP27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q24   Ensembl cytogenetic band:  1q24.1   HGNC cytogenetic band: 1q22-q24

DUSP27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP27 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P167063:  view genomic region     (about GC identifiers)

Start:
167,063,282 bp from pter      End:
167,098,402 bp from pter
Size:
35,121 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS27_HUMAN, Q5VZP5 (See protein sequence)
Recommended Name: Inactive dual specificity phosphatase 27  
Size: 1158 amino acids; 130176 Da
Caution: Ser-225 is present instead of the conserved Cys which is expected to be an active site residue suggesting
that this protein has lost its phosphatase activity
Sequence caution: Sequence=AAK02011.1; Type=Erroneous initiation;
Secondary accessions: A0AUM4 Q9C074

Explore the universe of human proteins at neXtProt for DUSP27: NX_Q5VZP5

Explore proteomics data for DUSP27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VZP5

  • DUSP27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DUSP27 Protein Expression
    REFSEQ proteins: NP_001073895.1  
    ENSEMBL proteins: 
     ENSP00000354483   ENSP00000271385   ENSP00000404874  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR020417 Atypical_DUSP
     IPR024950 DUSP
     IPR020405 Atypical_DUSP_famA

    Graphical View of Domain Structure for InterPro Entry Q5VZP5

    ProtoNet protein and cluster: Q5VZP5

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS27_HUMAN, Q5VZP5
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0016791phosphatase activity ----
         
    DUSP27 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DUSP27:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP27

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IBA--
    GO:0016311dephosphorylation ----

    DUSP27 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP27 (DUS27)

    Search CenterWatch for drugs/clinical trials and news about DUSP27 / DUS27

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP27 gene: 
    NM_001080426.1  

    Unigene Cluster for DUSP27:

    Dual specificity phosphatase 27 (putative)
    Hs.632462  [show with all ESTs]
    Unigene Representative Sequence: NM_001080426
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361200 ENST00000485151 ENST00000271385 ENST00000443333(uc001geb.1)

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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP27

    Additional mRNA sequence: 

    AF119045.1 AK094814.1 BC115387.1 

    3 DOTS entries:

    DT.40113446  DT.91944047  DT.91893589 

    1 AceView cDNA sequence:

    BX503288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DUSP27 Expression
    About this image


    See DUSP27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP27

    SOURCE GeneReport for Unigene cluster: Hs.632462
        SABiosciences Custom PCR Arrays for DUSP27
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DUSP27 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp271 , 5 dual specificity phosphatase 27 (putative)1, 5 83.25(n)1
    83.25(a)1
      1 (73.45 cM)5
    2408921  NM_001033344.31  NP_001028516.21 
     1660981535 
    chicken
    (Gallus gallus)
    Aves DUSP271 dual specificity phosphatase 27 (putative) 64(n)
    61.37(a)
      418444  XM_416655.3  XP_416655.3 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP276
    Uncharacterized protein
    57(a)
    1 ↔ 1
    3(163450300-163456853)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7926231 uncharacterized LOC792623 54.38(n)
    46.54(a)
      792623  XM_003197607.1  XP_003197655.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73786
    --
    35(a)
    1 → many
    X(18794443-18803330)


    ENSEMBL Gene Tree for DUSP27 (if available)
    TreeFam Gene Tree for DUSP27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP27 gene
    DUSP192  DUSP262  DUPD12  DUSP32  DUSP132  DUSP152  DUSP222  DUSP122  
    STYX2  
    4 SIMAP similar genes for DUSP27 using alignment to 1 protein entry:     DUS27_HUMAN:
    DUPD1    DUSP13    DUSP26    DUSP3

    DUSP27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/946 SNPs in DUSP27 are shown (see all 946)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507873001,2
    --167062099(+) GTGTCC/TCATTC 1 -- us2k10--------
    rs1391953501,2
    C--167062106(+) ATTCCC/TCCTAA 1 -- us2k10--------
    rs120424911,2
    H--167062109(+) CCTCCT/GAATAA 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs1498856821,2
    --167062129(+) TCATTC/GATTCA 1 -- us2k10--------
    rs1867757521,2
    --167062312(+) TGGTAC/TGTGTG 1 -- us2k10--------
    rs37539161,2
    C,F,H--167062414(+) GCTCAT/CGGAAT 1 -- us2k116Minor allele frequency- C:0.25EA NA NS CSA WA 2421
    rs37539171,2
    C,F,H--167062461(+) TTGGGG/TTGTGA 1 -- us2k1 tfbs319Minor allele frequency- T:0.25EA NA NS CSA WA 2835
    rs64270601,2
    C,F,H--167062518(+) CATCCA/TGAGAC 1 -- us2k119Minor allele frequency- T:0.02NS EA NA WA CSA 975
    rs1438645401,2
    --167062622(+) AGGAGA/CTCGAG 1 -- us2k10--------
    rs37539181,2
    C,F,H--167062644(+) CAACAC/TAGTGA 1 -- us2k16Minor allele frequency- T:0.36NA CSA 11

    HapMap Linkage Disequilibrium report for DUSP27 (167063282 - 167098402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DUSP27:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719184CNV Deletion23290073
    esv2750815CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for DUSP27:    About MalaCards
    heroin dependence    essential hypertension    hypertension


    DUSP27 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DUSP27
    Human Genome Epidemiology (HuGE) Navigator: DUSP27 (3 documents)

    Export disorders for DUSP27 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP27 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DUSP27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Genome-wide association study identifies genes that m ay contribute to risk for developing heroin addiction. (PubMed id 20520587)1, 4 Nielsen D.A....Kreek M.J. (2010)
    3. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    4. Structure of human dual-specificity phosphatase 27 at 2.38 A resolution. (PubMed id 21543850)1 Lountos G.T.... Waugh D.S. (2011)
    5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92235 HGNC: 25034 AceView: LOC92235.1 Ensembl:ENSG00000198842 euGenes: HUgn92235
    ECgene: DUSP27 H-InvDB: DUSP27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP27 gene:
    Search GeneIP for patents involving DUSP27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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