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DUSP26 Gene

protein-coding   GIFtS: 49
GCID: GC08M033448

Dual Specificity Phosphatase 26 (Putative)

  See DUSP26-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 26 (Putative)1 2     NATA12 3
Dual Specificity Phosphatase SKRP32 3     SKRP32 3
Low-Molecular-Mass Dual-Specificity Phosphatase 42 3     MAP Kinase Phosphatase 82 3
Mitogen-Activated Protein Kinase Phosphatase 82 3     Novel Amplified Gene In Thyroid Anaplastic Cancer2 3
DSP-42 3     Dual Specificity Protein Phosphatase 262
DUSP242 3     Dual-Specificity Phosphatase SKRP32
LDP-42 3     EC 3.1.3.163
MKP-82 3     EC 3.1.3.483
MKP82 3     LDP43

External Ids:    HGNC: 281611   Entrez Gene: 789862   Ensembl: ENSG000001338787   UniProtKB: Q9BV473   

Export aliases for DUSP26 gene to outside databases

Previous GC identifers: GC08M033569 GC08M031980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DUSP26 Gene:
DUSP26 (dual specificity phosphatase 26 (putative)) is a protein-coding gene. Diseases associated with DUSP26 include embryonal cancer. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP21.

UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a
reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated
apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal
kinase (JNK)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP26 gene promoter:
         Lmo2   AP-4   GATA-2   YY1   Evi-1   E47   MEF-2A   c-Myb   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP26 promoter sequence
   Search Chromatin IP Primers for DUSP26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

DUSP26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP26 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M033448:  view genomic region     (about GC identifiers)

Start:
33,448,851 bp from pter      End:
33,457,624 bp from pter
Size:
8,774 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 26  
Size: 211 amino acids; 23946 Da
Subunit: Interacts with HSF4
3 PDB 3D structures from and Proteopedia for DUSP26:
2E0T (3D)        4B04 (3D)        4HRF (3D)    
Secondary accessions: D3DSV8 Q9BTW0
Alternative splicing: 2 isoforms:  Q9BV47-1   Q9BV47-2   

Explore the universe of human proteins at neXtProt for DUSP26: NX_Q9BV47

Explore proteomics data for DUSP26 at MOPED


See DUSP26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_076930.1  
ENSEMBL proteins: 
 ENSP00000256261   ENSP00000429176   ENSP00000430922  

DUSP26 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for DUSP26

 
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antibodies-online proteins for DUSP26 (6 products) 

 
Search antibodies-online for peptides for DUSP26

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antibodies-online antibodies for DUSP26 (34 products) 

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antibodies-online kits for DUSP26 (8 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Selected InterPro protein domains (see all 7):
 IPR000387 Tyr/Dual-sp_Pase
 IPR020422 Dual-sp_phosphatase_subgr_cat
 IPR016130 Tyr_Pase_AS
 IPR020417 Atypical_DUSP
 IPR024950 DUSP

Graphical View of Domain Structure for InterPro Entry Q9BV47

ProtoNet protein and cluster: Q9BV47

1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain


Find genes that share domains with DUSP26           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DUS26_HUMAN, Q9BV47
Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a
reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated
apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal
kinase (JNK)
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

     Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

     Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001102RNA polymerase II activating transcription factor binding IPI16581800
GO:0002039p53 binding IPI--
GO:0004647phosphoserine phosphatase activity IMP15796912
GO:0004721phosphoprotein phosphatase activity IDA19043453
GO:0004725protein tyrosine phosphatase activity IMP15796912
     
Find genes that share ontologies with DUSP26           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for DUSP26:
 Decreased G3BP1 protein expres  Decreased focal adhesion (FA)  

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dusp26):
 integument 

Find genes that share phenotypes with DUSP26           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DUSP26

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat DUSP26 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate DUSP26:
hsa-miR-1914 hsa-miR-636 hsa-miR-3605-5p
SwitchGear 3'UTR luciferase reporter plasmidDUSP26 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DUSP26
Predesigned siRNA for gene silencing in human, mouse, rat DUSP26

Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP26

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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP26


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DUS26_HUMAN, Q9BV47: Cytoplasm. Nucleus. Golgi apparatus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
nucleus5
mitochondrion3
cytosol1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA15796912
GO:0005737cytoplasm IDA15796912
GO:0005739mitochondrion IEA--
GO:0005794Golgi apparatus IDA19043453
GO:0070062extracellular vesicular exosome IDA19056867

Find genes that share ontologies with DUSP26           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including DUSP26: 
          Protein Phosphatases in human mouse rat

Interactions:

    GeneGlobe Interaction Network for DUSP26

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for DUSP26 (Q9BV471, 3 ENSP000002562614) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
TP53P046371, 3, ENSP000002693054EBI-2924519,EBI-366083 I2D: score=2 STRING: ENSP00000269305
HSF4Q9ULV53, ENSP000002640094I2D: score=2 STRING: ENSP00000264009
TGFBR1P368973I2D: score=2 
ACVR1Q047713I2D: score=1 
CDH2P190223I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16581800
GO:0006470protein dephosphorylation IDA15796912
GO:0016311dephosphorylation ----
GO:0035335peptidyl-tyrosine dephosphorylation IMP15796912
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation IMP15796912

Find genes that share ontologies with DUSP26           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DUSP26 (DUS26)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DUSP26 gene: 
NM_024025.1  

Unigene Cluster for DUSP26:

Dual specificity phosphatase 26 (putative)
Hs.8719  [show with all ESTs]
Unigene Representative Sequence: AB158288
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000256261(uc003xjp.3 uc003xjq.3) ENST00000523956 ENST00000522982

miRNA
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Block miRNA regulation of human, mouse, rat DUSP26 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate DUSP26:
hsa-miR-1914 hsa-miR-636 hsa-miR-3605-5p
SwitchGear 3'UTR luciferase reporter plasmidDUSP26 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat DUSP26
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GenScript: all cDNA clones in your preferred vector: DUSP26 (NM_024025)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP26
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP26
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DUSP26
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP26
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP26
  QuantiTect SYBR Green Assays in human, mouse, rat DUSP26
  QuantiFast Probe-based Assays in human, mouse, rat DUSP26

Additional mRNA sequence: 

AB103376.1 AB158288.1 AB237597.1 AK055704.1 AY902194.1 BC001613.1 BC003115.1 BC067804.1 

8 DOTS entries:

DT.454956  DT.95276377  DT.97809645  DT.121482126  DT.100712405  DT.100694419  DT.95276375  DT.95276376 

Selected AceView cDNA sequences (see all 165):

F36674 F23450 T33292 F08410 CR604644 CR621684 F28731 NM_024025 
CR616533 AI221332 BM508053 AK055704 CR608742 CA946911 BU790358 AI609568 
AI651722 AA056327 BU790059 BQ417261 BQ287804 BC003115 BQ129969 BM684381 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP26    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:        -                           
SP2:        -                           
SP3:                                    
SP4:                                    


ECgene alternative splicing isoforms for DUSP26

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DUSP26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DUSP26 Expression
About this image


DUSP26 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Neural Tube (Nervous System)
         Mesencephalic Basal Plate
 
 Skeletal Muscle (Muscoskeletal System)
DUSP26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DUSP26 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.8719

UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
Tissue specificity: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in
embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer

    Pathway & Disease-focused RT2 Profiler PCR Array including DUSP26: 
          Protein Phosphatases in human mouse rat

Primer
Products:
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QuantiFast Probe-based Assays in human, mouse, rat DUSP26
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP26

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DUSP26 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dusp261 , 5 dual specificity phosphatase 26 (putative)1, 5 90.68(n)1
96.68(a)1
  8 (17.93 cM)5
669591  NM_025869.31  NP_080145.11 
 310894715 
chicken
(Gallus gallus)
Aves DUSP261 dual specificity phosphatase 26 (putative) 76.91(n)
80.12(a)
  426921  XM_424530.3  XP_424530.1 
lizard
(Anolis carolinensis)
Reptilia DUSP266
dual specificity phosphatase 26 (putative)
73(a)
1 ↔ 1
GL343238.1(1108141-1120505)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004934431 dual specificity protein phosphatase 26-like 63.05(n)
70.48(a)
  100493443  XM_002932969.2  XP_002933015.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5708151 piggyBac transposable element-derived protein 4-like 69.48(n)
70.48(a)
  570815  XM_694337.3  XP_699429.2 
fruit fly
(Drosophila melanogaster)
Insecta CG73781 CG7378 56.35(n)
53.96(a)
  32888  NM_001103557.1  NP_001097027.1 


ENSEMBL Gene Tree for DUSP26 (if available)
TreeFam Gene Tree for DUSP26 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DUSP26 gene
DUSP212  DUPD12  DUSP32  DUSP132  DUSP272  STYX2  DUSP192  DUSP142  
DUSP282  DUSP152  DUSP222  DUSP182  
6 SIMAP similar genes for DUSP26 using alignment to 2 protein entries:     DUS26_HUMAN (see all proteins):
DUSP27    DUPD1    DUSP13    DUSP3    DUSP14    DUSP5

Find genes that share paralogs with DUSP26           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DUSP26 (see all 265)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1899953901,2
--33448403(+) ACCGTG/TCCCGG 1 -- int10--------
rs1132479081,2
C,F--33448457(+) GCCAGG/CCTGGT 1 -- int11Minor allele frequency- C:0.50WA 2
rs1825835761,2
--33448624(+) CTGGTA/CCTCTG 1 -- int10--------
rs1849201661,2
--33448703(+) GGGAGA/TATAGC 1 -- int10--------
rs776977371,2
C,F--33448778(+) TCTCCA/CGCAAG 1 -- int11Minor allele frequency- C:0.04WA 118
rs802247601,2
C,F--33448881(+) GAGACG/ACTTGG 1 -- ut313Minor allele frequency- A:0.08CSA WA 122
rs1168502681,2
C,F--33448936(+) TCTGTA/TTGTTT 1 -- ut311Minor allele frequency- T:0.02NA 120
rs1897307341,2
--33448971(+) CTAGTA/GCCAAC 1 -- ut310--------
rs1827619981,2
--33449058(+) TCACAA/CCATCT 1 -- ut310--------
rs1890261941,2
--33449194(+) AGAGGG/TAAACA 1 -- ut310--------

HapMap Linkage Disequilibrium report for DUSP26 (33448851 - 33457624 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DUSP26:    About this table    
Variant IDTypeSubtypePubMed ID
esv2752251CNV Loss17911159

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DUSP26
DNA2.0 Custom Variant and Variant Library Synthesis for DUSP26

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for DUSP26:    
About MalaCards
embryonal cancer


Find genes that share disorders with DUSP26           About GenesLikeMe

Genetic Association Database (GAD): DUSP26
Human Genome Epidemiology (HuGE) Navigator: DUSP26 (1 document)

Export disorders for DUSP26 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DUSP26 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with DUSP26)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. (PubMed id 16924234)1, 2, 9 Yu W.... Inazawa J. (Oncogene 2007)
  2. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. (PubMed id 15796912)1, 2, 9 Vasudevan S.A.... Yang J. (Biochem. Biophys. Res. Commun. 2005)
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  4. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. (PubMed id 17001450)1, 2 Takagaki K....Kikuchi K. (Mol. Cell. Biochem. 2007)
  5. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PubMed id 16581800)1, 2 Hu Y. and Mivechi N.F. (Mol. Cell. Biol. 2006)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. (PubMed id 23298255)1 Lokareddy R.K....Cingolani G. (Biochemistry 2013)
  8. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. (PubMed id 20562916)1 Shang X....Yang J. (Oncogene 2010)
  9. DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs. (PubMed id 20347885)1 Patterson K.I....O'Brien P.M. (Biochim. Biophys. Acta 2010)
  10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 78986 HGNC: 28161 AceView: MGC1136 Ensembl:ENSG00000133878 euGenes: HUgn78986
ECgene: DUSP26 H-InvDB: DUSP26

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DUSP26 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DUSP26 gene:
Search GeneIP for patents involving DUSP26

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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