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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP26 Gene

protein-coding   GIFtS: 48
GCID: GC08M033448

dual specificity phosphatase 26 (putative)

 Explore 7 diseases affiliated with
DUSP26 via our new
 Human Malady Compendium 
Biological research products
for DUSP26
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 26 (Putative)1 2     SKRP32 3
DUSP241 2 3     MAP Kinase Phosphatase 82 3
Dual Specificity Phosphatase SKRP32 3     Novel Amplified Gene In Thyroid Anaplastic Cancer2 3
Low-Molecular-Mass Dual-Specificity Phosphatase 42 3     MGC11361
Mitogen-Activated Protein Kinase Phosphatase 82 3     Dual Specificity Protein Phosphatase 262
DSP-42 3     Dual-Specificity Phosphatase SKRP32
LDP-42 3     EC 3.1.3.163
MKP-82 3     EC 3.1.3.483
MKP82 3     LDP43
NATA12 3     

External Ids:    HGNC: 281611   Entrez Gene: 789862   Ensembl: ENSG000001338787   UniProtKB: Q9BV473   

Export aliases for DUSP26 gene to outside databases

Previous GC identifers: GC08M033569 GC08M031980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction
in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in
anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP26 gene promoter:
         Lmo2   AP-4   GATA-2   YY1   Evi-1   E47   MEF-2A   c-Myb   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP26 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP26

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

DUSP26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP26 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M033448:  view genomic region     (about GC identifiers)

Start:
33,448,851 bp from pter      End:
33,457,624 bp from pter
Size:
8,774 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 26  
Size: 211 amino acids; 23946 Da
Subunit: Interacts with HSF4
Subcellular location: Cytoplasm. Nucleus. Golgi apparatus
2 PDB 3D structures from and Proteopedia for DUSP26:
2E0T (3D)        4HRF (3D)    
Secondary accessions: D3DSV8 Q9BTW0
Alternative splicing: 2 isoforms:  Q9BV47-1   Q9BV47-2   

Explore the universe of human proteins at neXtProt for DUSP26: NX_Q9BV47

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BV47

  • DUSP26 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076930.1  
    ENSEMBL proteins: 
     ENSP00000256261   ENSP00000429176   ENSP00000430922  

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    Uscn Proteins for DUSP26

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IEA--


    DUSP26 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DUSP26 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR020417 Atypical_DUSP
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q9BV47

    ProtoNet protein and cluster: Q9BV47

    1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
    Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction
    in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in
    anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--


    DUSP26 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DUSP26:
     Decreased G3BP1 protein expres  Decreased focal adhesion (FA)  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP26

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/10 Interacting proteins for DUSP26 (Q9BV471, 3 ENSP000002562614) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 3, ENSP000002693054EBI-2924519,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    HSF4Q9ULV53, ENSP000002640094I2D: score=2 STRING: ENSP00000264009
    TGFBR1P368973I2D: score=2 
    ACVR1Q047713I2D: score=1 
    CDH2P190223I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IBA--


    DUSP26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP26
    Search CenterWatch for drugs/clinical trials and news about DUSP26 / DUS26 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP26 gene: 
    NM_024025.1  

    Unigene Cluster for DUSP26:

    Dual specificity phosphatase 26 (putative)
    Hs.8719  [show with all ESTs]
    Unigene Representative Sequence: AB158288
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256261(uc003xjp.3 uc003xjq.3) ENST00000523956 ENST00000522982


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    Additional cDNA sequence: 

    AB103376.1 AB158288.1 AB237597.1 AK055704.1 AY902194.1 BC001613.1 BC003115.1 BC067804.1 

    8 DOTS entries:

    DT.454956  DT.95276377  DT.97809645  DT.121482126  DT.100712405  DT.100694419  DT.95276375  DT.95276376 

    24/165 AceView cDNA sequences (see all 165):

    Z41401 AI479964 BQ129969 F10729 CR608742 BC003115 F23450 AI609568 
    BU790358 F02117 AK055704 BM508053 BX440640 T33292 BI522443 CA946911 
    F36674 BM920856 BQ287804 F28731 CR621684 CR616533 BC001613 BU790059 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP26    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:        -                           
    SP2:        -                           
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for DUSP26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DUSP26 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP26

    SOURCE GeneReport for Unigene cluster: Hs.8719

    UniProtKB/Swiss-Prot: DUS26_HUMAN, Q9BV47
    Tissue specificity: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal
    cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer

        SABiosciences Expression via Pathway-Focused PCR Array including DUSP26: 
              Protein Phosphatases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP26 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DUSP261 dual specificity phosphatase 26 (putative) 75.26(n)
    77.37(a)
      426921  XM_424530.2  XP_424530.1 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP266
    --
    74(a)
    1 ↔ 1
    GL343238.1(1108141-1112718)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5708151 dual specificity protein phosphatase 26-like 66.84(n)
    67.02(a)
      570815  XM_694337.2  XP_699429.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73781 CG7378 56.76(n)
    54.35(a)
      32888  NM_001103557.1  NP_001097027.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PHS16
    dual specificity protein phosphatase family protei...
    6(a)
    1 → many
    5(7998230-8002840)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    PHS1, putative, expressed
    7(a)
    6(a)
    many ↔ many
    many ↔ many
    1(13793660-13798880)
    1(11692783-11698999)


    ENSEMBL Gene Tree for DUSP26 (if available)
    TreeFam Gene Tree for DUSP26 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP26 gene
    DUPD12  DUSP32  DUSP132  DUSP272  
    6 SIMAP similar genes for DUSP26 using alignment to 2 protein entries:     DUS26_HUMAN (see all proteins):
    DUSP27    DUPD1    DUSP13    DUSP3    DUSP14    DUSP5

    DUSP26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 NCBI SNPs in DUSP26 are shown (see all 201    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899953901,2
    --33448403(+) ACCGTG/TCCCGG 1 -- int10--------
    rs1132479081,2
    C,--33448457(+) GCCAGG/CCTGGT 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1825835761,2
    --33448624(+) CTGGTA/CCTCTG 1 -- int10--------
    rs1849201661,2
    --33448703(+) GGGAGA/TATAGC 1 -- int10--------
    rs776977371,2
    C,F,--33448778(+) TCTCCA/CGCAAG 1 -- int11Minor allele frequency- C:0.04WA 118
    rs802247601,2
    C,F,--33448881(+) GAGACG/ACTTGG 1 -- ut313Minor allele frequency- A:0.08CSA WA 122
    rs1168502681,2
    F,--33448936(+) TCTGTA/TTGTTT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs1897307341,2
    --33448971(+) CTAGTA/GCCAAC 1 -- ut310--------
    rs1827619981,2
    --33449058(+) TCACAA/CCATCT 1 -- ut310--------
    rs1890261941,2
    --33449194(+) AGAGGG/TAAACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DUSP26 (33448851 - 33457624 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DUSP26
         1 CNV: 9090

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DUSP26 for disorders           About GeneDecksing

    7 diseases for DUSP26:    About MalaCards
    cone-rod dystrophy    thyroiditis    embryonal cancer    thyroid cancer
    retinoblastoma    neuroblastoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: DUSP26 (1 document)

    Export disorders for DUSP26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP26 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DUSP26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. (PubMed id 16924234)1, 2, 9 Yu W.... Inazawa J. (2007)
    2. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. (PubMed id 15796912)1, 2, 9 Vasudevan S.A.... Yang J. (2005)
    3. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. (PubMed id 17001450)1, 2 Takagaki K....Kikuchi K. (2007)
    4. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PubMed id 16581800)1, 2 Hu Y. and Mivechi N.F. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    7. Dual-specificity phosphatase 26 is a novel p53 phosph atase and inhibits p53 tumor suppressor functions in human neuroblastoma. (PubMed id 20562916)1 Shang X....Yang J. (2010)
    8. DUSP26 negatively affects the proliferation of epithe lial cells, an effect not mediated by dephosphorylation of MAPKs. (PubMed id 20347885)1 Patterson K.I....O'Brien P.M. (2010)
    9. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. (PubMed id 19043453)1 Tanuma N....Shima H. (2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 78986 HGNC: 28161 AceView: MGC1136 Ensembl:ENSG00000133878 euGenes: HUgn78986
    ECgene: DUSP26 H-InvDB: DUSP26

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP26 gene:
    Search GeneIP for patents involving DUSP26

    GeneCards and IP:
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