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Aliases for DUSP26 Gene

Aliases for DUSP26 Gene

  • Dual Specificity Phosphatase 26 (Putative) 2 3
  • Low-Molecular-Mass Dual-Specificity Phosphatase 4 3 4
  • Novel Amplified Gene In Thyroid Anaplastic Cancer 3 4
  • Mitogen-Activated Protein Kinase Phosphatase 8 3 4
  • Dual Specificity Phosphatase SKRP3 3 4
  • MAP Kinase Phosphatase 8 3 4
  • DUSP24 3 4
  • DSP-4 3 4
  • LDP-4 3 4
  • MKP-8 3 4
  • NATA1 3 4
  • SKRP3 3 4
  • MKP8 3 4
  • Dual Specificity Protein Phosphatase 26 3
  • Neuroendocrine-Associated Phosphatase 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • NEAP 3
  • LDP4 4

External Ids for DUSP26 Gene

Summaries for DUSP26 Gene

Entrez Gene Summary for DUSP26 Gene

  • This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for DUSP26 Gene

DUSP26 (Dual Specificity Phosphatase 26 (Putative)) is a Protein Coding gene. Diseases associated with DUSP26 include embryonal cancer. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

UniProtKB/Swiss-Prot for DUSP26 Gene

  • Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP26 Gene

Genomics for DUSP26 Gene

Genomic Location for DUSP26 Gene

Start:
33,591,330 bp from pter
End:
33,600,106 bp from pter
Size:
8,777 bases
Orientation:
Minus strand

Genomic View for DUSP26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP26 Gene

Regulatory Elements for DUSP26 Gene

Proteins for DUSP26 Gene

  • Protein details for DUSP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV47-DUS26_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 26
    Protein Accession:
    Q9BV47
    Secondary Accessions:
    • D3DSV8
    • Q9BTW0

    Protein attributes for DUSP26 Gene

    Size:
    211 amino acids
    Molecular mass:
    23946 Da
    Quaternary structure:
    • Interacts with HSF4.

    Three dimensional structures from OCA and Proteopedia for DUSP26 Gene

    Alternative splice isoforms for DUSP26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP26 Gene

Proteomics data for DUSP26 Gene at MOPED

Post-translational modifications for DUSP26 Gene

No Post-translational modifications

Other Protein References for DUSP26 Gene

No data available for DME Specific Peptides for DUSP26 Gene

Domains for DUSP26 Gene

Gene Families for DUSP26 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

UniProtKB/Swiss-Prot:

DUS26_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q9BV47
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • Q9BV47
genes like me logo Genes that share domains with DUSP26: view

Function for DUSP26 Gene

Molecular function for DUSP26 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).

Enzyme Numbers (IUBMB) for DUSP26 Gene

Gene Ontology (GO) - Molecular Function for DUSP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16581800
GO:0002039 p53 binding IPI 20562916
GO:0004647 phosphoserine phosphatase activity IMP 15796912
GO:0004721 phosphoprotein phosphatase activity IDA 19043453
GO:0004725 protein tyrosine phosphatase activity IMP 15796912
genes like me logo Genes that share ontologies with DUSP26: view
genes like me logo Genes that share phenotypes with DUSP26: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUSP26 Gene

Localization for DUSP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP26 Gene

Cytoplasm. Nucleus. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP26 Gene COMPARTMENTS Subcellular localization image for DUSP26 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for DUSP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15796912
GO:0005737 cytoplasm IDA 15796912
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA 19043453
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DUSP26: view

Pathways for DUSP26 Gene

SuperPathways for DUSP26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16581800
GO:0006470 protein dephosphorylation IDA 15796912
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IMP 15796912
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IMP 15796912
genes like me logo Genes that share ontologies with DUSP26: view

No data available for Pathways by source for DUSP26 Gene

Transcripts for DUSP26 Gene

Unigene Clusters for DUSP26 Gene

Dual specificity phosphatase 26 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP26 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for DUSP26 Gene

GeneLoc Exon Structure for
DUSP26
ECgene alternative splicing isoforms for
DUSP26

Expression for DUSP26 Gene

mRNA expression in normal human tissues for DUSP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP26 Gene

This gene is overexpressed in Muscle - Skeletal (10.6).

SOURCE GeneReport for Unigene cluster for DUSP26 Gene Hs.8719

mRNA Expression by UniProt/SwissProt for DUSP26 Gene

Q9BV47-DUS26_HUMAN
Tissue specificity: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
genes like me logo Genes that share expressions with DUSP26: view

Orthologs for DUSP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP26 36
  • 99.68 (n)
  • 100 (a)
DUSP26 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP26 36
  • 88.31 (n)
  • 93.84 (a)
DUSP26 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP26 36
  • 93.36 (n)
  • 97.63 (a)
DUSP26 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp26 36
  • 90.68 (n)
  • 96.68 (a)
Dusp26 16
Dusp26 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP26 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP26 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp26 36
  • 91.15 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves DUSP26 36
  • 76.91 (n)
  • 80.12 (a)
DUSP26 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP26 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493443 36
  • 63.05 (n)
  • 70.48 (a)
zebrafish
(Danio rerio)
Actinopterygii DUSP26 37
  • 42 (a)
OneToMany
LOC570815 36
  • 69.48 (n)
  • 70.48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008228 36
  • 55 (n)
  • 46.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7378 36
  • 56.35 (n)
  • 53.96 (a)
CG7378 37
  • 35 (a)
OneToMany
Species with no ortholog for DUSP26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP26 Gene

ENSEMBL:
Gene Tree for DUSP26 (if available)
TreeFam:
Gene Tree for DUSP26 (if available)

Paralogs for DUSP26 Gene

Selected SIMAP similar genes for DUSP26 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DUSP26: view

Variants for DUSP26 Gene

Sequence variations from dbSNP and Humsavar for DUSP26 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs894536 -- 33,597,072(-) CCTGT(A/G)ATCCC intron-variant
rs1044115 -- 33,599,851(-) GTCAC(C/T)AGCGC utr-variant-5-prime
rs1077285 -- 33,595,977(-) cacat(C/T)atctc intron-variant
rs1257809 -- 33,594,829(+) aacga(A/T)tctcc intron-variant
rs1272201 -- 33,594,900(+) tgtat(C/T)tttag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP26 Gene

Variant ID Type Subtype PubMed ID
esv2752251 CNV Loss 17911159

Relevant External Links for DUSP26 Gene

HapMap Linkage Disequilibrium report
DUSP26

Disorders for DUSP26 Gene

(1) MalaCards Diseases for DUSP26 Gene

Search for DUSP26 Gene in MalaCards »

Relevant External Links for DUSP26

Genetic Association Database (GAD)
DUSP26
Human Genome Epidemiology (HuGE) Navigator
DUSP26
genes like me logo Genes that share disorders with DUSP26: view

No data available for UniProtKB/Swiss-Prot for DUSP26 Gene

Publications for DUSP26 Gene

  1. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. (PMID: 15796912) Vasudevan S.A. … Yang J. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. (PMID: 16924234) Yu W. … Inazawa J. (Oncogene 2007) 3 4 23
  3. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. (PMID: 17001450) Takagaki K. … Kikuchi K. (Mol. Cell. Biochem. 2007) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DUSP26 Gene

  • antibodies-online proteins for DUSP26
  • antibodies-online antibodies for DUSP26
  • antibodies-online kits for DUSP26

Sources for DUSP26 Gene

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