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Aliases for DUSP23 Gene

Aliases for DUSP23 Gene

  • Dual Specificity Phosphatase 23 2 3 5
  • VH1-Like Phosphatase Z 3 4
  • LDP-3 3 4
  • VHZ 3 4
  • Low-Molecular-Mass Dual-Specificity Phosphatase 3 3
  • Low Molecular Mass Dual Specificity Phosphatase 3 4
  • Dual Specificity Protein Phosphatase 23 3
  • Testicular Tissue Protein Li 59 3
  • VH1-Like Member Z 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP25 3
  • MOSP 3
  • LDP3 4

External Ids for DUSP23 Gene

Previous GeneCards Identifiers for DUSP23 Gene

  • GC01P156968
  • GC01P156563
  • GC01P158017
  • GC01P131107

Summaries for DUSP23 Gene

GeneCards Summary for DUSP23 Gene

DUSP23 (Dual Specificity Phosphatase 23) is a Protein Coding gene. Diseases associated with DUSP23 include Neuronal Intestinal Dysplasia. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot for DUSP23 Gene

  • Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).

Gene Wiki entry for DUSP23 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP23 Gene

Genomics for DUSP23 Gene

Regulatory Elements for DUSP23 Gene

Enhancers for DUSP23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G159888 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +109.6 109552 3.0 HDGF ATF1 SIN3A ZNF2 GLIS2 GATA2 ZNF207 ZNF143 FOS DEK ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01G159751 1.1 Ensembl ENCODE 10.1 -28.3 -28319 3.2 TBP RAD21 YY1 CBX5 SCRT2 RCOR1 SMARCC1 USF2 CEBPB NR2F2 CRP FCRL6 DUSP23 ENSG00000212161 AIM2 RPL27P2
GH01G159959 0.8 ENCODE 9.6 +178.6 178559 0.9 ATF1 ETV1 CTBP1 GATA3 ZNF766 EGR1 POLR2A SCRT2 KDM5B NFE2 ENSG00000212161 ENSG00000225279 DUSP23 FCRL6 LINC01133 SLAMF9
GH01G159960 0.8 Ensembl ENCODE 9.6 +180.6 180589 2.3 ATF1 KLF1 ZFHX2 IKZF1 GLIS1 GABPA EGR2 ENSG00000212161 ENSG00000225279 LINC01133 DUSP23 FCRL6 FCRL6P1
GH01G159211 0.7 Ensembl 9.1 -569.5 -569532 0.4 SCRT1 CTCF ZNF654 ARNT CEBPB TRIM22 REST CEBPG RAD21 ATF3 CADM3 AIM2 OR10J2P FCER1A OR10J3 DUSP23 ACKR1 CADM3-AS1 MPTX1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP23 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014450 168 1401 HDGF PKNOX1 ATF1 CREB3L1 SIN3A YY1 ZNF143 KLF13 REST MBD2

Genomic Location for DUSP23 Gene

Chromosome:
1
Start:
159,780,932 bp from pter
End:
159,782,543 bp from pter
Size:
1,612 bases
Orientation:
Plus strand

Genomic View for DUSP23 Gene

Genes around DUSP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP23 Gene

Proteins for DUSP23 Gene

  • Protein details for DUSP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVJ7-DUS23_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 23
    Protein Accession:
    Q9BVJ7
    Secondary Accessions:
    • Q9NX48

    Protein attributes for DUSP23 Gene

    Size:
    150 amino acids
    Molecular mass:
    16588 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP23 Gene

neXtProt entry for DUSP23 Gene

Post-translational modifications for DUSP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP23 Gene

No data available for DME Specific Peptides for DUSP23 Gene

Domains & Families for DUSP23 Gene

Gene Families for DUSP23 Gene

Suggested Antigen Peptide Sequences for DUSP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVJ7

UniProtKB/Swiss-Prot:

DUS23_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP23: view

Function for DUSP23 Gene

Molecular function for DUSP23 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate {ECO:0000269 PubMed:15201283};
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).

Enzyme Numbers (IUBMB) for DUSP23 Gene

Gene Ontology (GO) - Molecular Function for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IBA --
GO:0004725 protein tyrosine phosphatase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DUSP23: view
genes like me logo Genes that share phenotypes with DUSP23: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP23

CRISPR Products

miRNA for DUSP23 Gene

miRTarBase miRNAs that target DUSP23

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP23 Gene

Localization for DUSP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP23 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP23 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DUSP23: view

Pathways & Interactions for DUSP23 Gene

SuperPathways for DUSP23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IDA 24531476
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP23: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP23 Gene

Drugs & Compounds for DUSP23 Gene

(3) Drugs for DUSP23 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
4-Nitrophenyl phosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with DUSP23: view

Transcripts for DUSP23 Gene

Unigene Clusters for DUSP23 Gene

Dual specificity phosphatase 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -
SP3:

Relevant External Links for DUSP23 Gene

GeneLoc Exon Structure for
DUSP23
ECgene alternative splicing isoforms for
DUSP23

Expression for DUSP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP23 Gene

This gene is overexpressed in Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for DUSP23 Gene

This gene is overexpressed in Bone (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP23 Gene



Protein tissue co-expression partners for DUSP23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DUSP23 Gene:

DUSP23

SOURCE GeneReport for Unigene cluster for DUSP23 Gene:

Hs.425801

mRNA Expression by UniProt/SwissProt for DUSP23 Gene:

Q9BVJ7-DUS23_HUMAN
Tissue specificity: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.

Evidence on tissue expression from TISSUES for DUSP23 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with DUSP23: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP23 Gene

Orthologs for DUSP23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP23 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia DUSP23 34 35
  • 91.56 (n)
rat
(Rattus norvegicus)
Mammalia Dusp23 34
  • 90.22 (n)
mouse
(Mus musculus)
Mammalia Dusp23 34 16 35
  • 89.33 (n)
dog
(Canis familiaris)
Mammalia DUSP23 34 35
  • 86.46 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP23 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP23 34 35
  • 70.55 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP23 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp23 34
  • 67.42 (n)
Str.11103 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15941 34
zebrafish
(Danio rerio)
Actinopterygii zgc:92902 34
  • 67.11 (n)
DUSP23 (2 of 2) 35
  • 64 (a)
OneToMany
DUSP23 (1 of 2) 35
  • 54 (a)
OneToMany
Dr.8008 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.620 34
fruit fly
(Drosophila melanogaster)
Insecta cdc14 35
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-14 35
  • 4 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 35
  • 7 (a)
OneToMany
Species where no ortholog for DUSP23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP23 Gene

ENSEMBL:
Gene Tree for DUSP23 (if available)
TreeFam:
Gene Tree for DUSP23 (if available)

Paralogs for DUSP23 Gene

Paralogs for DUSP23 Gene

(3) SIMAP similar genes for DUSP23 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP23: view

Variants for DUSP23 Gene

Sequence variations from dbSNP and Humsavar for DUSP23 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000747334 -- 159,781,044(+) GGCGG(A/G)GCGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000833009 -- 159,780,481(+) GCAGC(A/C)GTAAT nc-transcript-variant, upstream-variant-2KB
rs1001201071 -- 159,781,311(+) CGGCC(A/C)CCGAC upstream-variant-2KB, reference, missense
rs1002125415 -- 159,781,870(+) ATCTC(A/G)GTTTG intron-variant, upstream-variant-2KB
rs1002200377 -- 159,781,565(+) TGCGA(-/ACTG)GGCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP23 Gene

Variant ID Type Subtype PubMed ID
nsv1005195 CNV gain 25217958

Variation tolerance for DUSP23 Gene

Gene Damage Index Score: 5.60; 72.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP23 Gene

Human Gene Mutation Database (HGMD)
DUSP23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP23 Gene

Disorders for DUSP23 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP23 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuronal intestinal dysplasia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP23

Genetic Association Database (GAD)
DUSP23
Human Genome Epidemiology (HuGE) Navigator
DUSP23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP23
genes like me logo Genes that share disorders with DUSP23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP23 Gene

Publications for DUSP23 Gene

  1. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. (PMID: 15147733) Wu Q. … Mao Y. (Int. J. Biochem. Cell Biol. 2004) 2 3 4 22 64
  2. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. (PMID: 15201283) Alonso A. … Mustelin T. (J. Biol. Chem. 2004) 3 4 22 64
  3. Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. (PMID: 21787189) Nyberg F. … Kamatani N. (Pharmacogenomics 2011) 3 46 64
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for DUSP23 Gene

Sources for DUSP23 Gene

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