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Aliases for DUSP23 Gene

Aliases for DUSP23 Gene

  • Dual Specificity Phosphatase 23 2 3
  • Low Molecular Mass Dual Specificity Phosphatase 3 3 4
  • VH1-Like Phosphatase Z 3 4
  • LDP-3 3 4
  • VHZ 3 4
  • Low-Molecular-Mass Dual-Specificity Phosphatase 3 3
  • Dual Specificity Protein Phosphatase 23 3
  • VH1-Like Member Z 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • DUSP25 3
  • MOSP 3
  • LDP3 4

External Ids for DUSP23 Gene

Previous GeneCards Identifiers for DUSP23 Gene

  • GC01P156968
  • GC01P156563
  • GC01P158017
  • GC01P131107

Summaries for DUSP23 Gene

GeneCards Summary for DUSP23 Gene

DUSP23 (Dual Specificity Phosphatase 23) is a Protein Coding gene. Diseases associated with DUSP23 include dental enamel hypoplasia and interstitial lung disease. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot for DUSP23 Gene

  • Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).

Gene Wiki entry for DUSP23 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP23 Gene

Genomics for DUSP23 Gene

Regulatory Elements for DUSP23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP23 Gene

Start:
159,780,932 bp from pter
End:
159,782,543 bp from pter
Size:
1,612 bases
Orientation:
Plus strand

Genomic View for DUSP23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP23 Gene

Proteins for DUSP23 Gene

  • Protein details for DUSP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVJ7-DUS23_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 23
    Protein Accession:
    Q9BVJ7
    Secondary Accessions:
    • Q9NX48

    Protein attributes for DUSP23 Gene

    Size:
    150 amino acids
    Molecular mass:
    16588 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP23 Gene

neXtProt entry for DUSP23 Gene

Proteomics data for DUSP23 Gene at MOPED

Post-translational modifications for DUSP23 Gene

No Post-translational modifications

Other Protein References for DUSP23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP23 Gene

Domains for DUSP23 Gene

Gene Families for DUSP23 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUSP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVJ7

UniProtKB/Swiss-Prot:

DUS23_HUMAN :
  • Q9BVJ7
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP23: view

Function for DUSP23 Gene

Molecular function for DUSP23 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate {ECO:0000269 PubMed:15201283};
UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).

Enzyme Numbers (IUBMB) for DUSP23 Gene

Gene Ontology (GO) - Molecular Function for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUSP23: view

Phenotypes for DUSP23 Gene

genes like me logo Genes that share phenotypes with DUSP23: view

Animal Model Products

CRISPR Products

miRNA for DUSP23 Gene

miRTarBase miRNAs that target DUSP23

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP23

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP23 Gene

Localization for DUSP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP23 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP23 Gene COMPARTMENTS Subcellular localization image for DUSP23 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DUSP23: view

Pathways for DUSP23 Gene

SuperPathways for DUSP23 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DUSP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP23: view

No data available for Pathways by source for DUSP23 Gene

Compounds for DUSP23 Gene

(1) Drugbank Compounds for DUSP23 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-Nitrophenyl Phosphate
330-13-2 target
genes like me logo Genes that share compounds with DUSP23: view

Transcripts for DUSP23 Gene

mRNA/cDNA for DUSP23 Gene

Unigene Clusters for DUSP23 Gene

Dual specificity phosphatase 23:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP23

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -
SP3:

Relevant External Links for DUSP23 Gene

GeneLoc Exon Structure for
DUSP23
ECgene alternative splicing isoforms for
DUSP23

Expression for DUSP23 Gene

mRNA expression in normal human tissues for DUSP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP23 Gene

This gene is overexpressed in Kidney - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP23 Gene

SOURCE GeneReport for Unigene cluster for DUSP23 Gene Hs.425801

mRNA Expression by UniProt/SwissProt for DUSP23 Gene

Q9BVJ7-DUS23_HUMAN
Tissue specificity: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.
genes like me logo Genes that share expressions with DUSP23: view

In Situ Assay Products

Orthologs for DUSP23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP23 35
  • 99.78 (n)
  • 100 (a)
DUSP23 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP23 35
  • 91.56 (n)
  • 96 (a)
DUSP23 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP23 35
  • 86.46 (n)
  • 96.87 (a)
DUSP23 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp23 35
  • 89.33 (n)
  • 95.33 (a)
Dusp23 16
Dusp23 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DUSP23 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp23 35
  • 90.22 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves DUSP23 35
  • 70.55 (n)
  • 66.44 (a)
DUSP23 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP23 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15941 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp23 35
  • 67.42 (n)
  • 63.64 (a)
Str.11103 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.620 35
zebrafish
(Danio rerio)
Actinopterygii Dr.8008 35
DUSP23 (1 of 2) 36
  • 54 (a)
OneToMany
DUSP23 (2 of 2) 36
  • 64 (a)
OneToMany
zgc:92902 35
  • 67.11 (n)
  • 65.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdc14 36
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdc-14 36
  • 4 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC14 36
  • 7 (a)
OneToMany
Species with no ortholog for DUSP23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP23 Gene

ENSEMBL:
Gene Tree for DUSP23 (if available)
TreeFam:
Gene Tree for DUSP23 (if available)

Paralogs for DUSP23 Gene

Paralogs for DUSP23 Gene

Selected SIMAP similar genes for DUSP23 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP23: view

Variants for DUSP23 Gene

Sequence variations from dbSNP and Humsavar for DUSP23 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1129923 - 159,782,276(+) GACCC(A/G)GCTCC missense, reference
rs1129932 -- 159,782,356(+) CCCTT(C/T)TACCA utr-variant-3-prime
rs11544443 - 159,782,256(-) GGATT(A/T)CAGCA reference, missense
rs11544445 -- 159,782,212(-) ACCAG(A/G)TAACA reference, synonymous-codon
rs11577540 -- 159,782,557(+) CATGG(G/T)ACTTT downstream-variant-500B

Relevant External Links for DUSP23 Gene

HapMap Linkage Disequilibrium report
DUSP23
Human Gene Mutation Database (HGMD)
DUSP23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DUSP23 Gene

Disorders for DUSP23 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for DUSP23 Gene including...

Search for DUSP23 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DUSP23 Gene

Relevant External Links for DUSP23

Genetic Association Database (GAD)
DUSP23
Human Genome Epidemiology (HuGE) Navigator
DUSP23
genes like me logo Genes that share disorders with DUSP23: view

No data available for UniProtKB/Swiss-Prot for DUSP23 Gene

Publications for DUSP23 Gene

  1. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. (PMID: 15147733) Wu Q. … Mao Y. (Int. J. Biochem. Cell Biol. 2004) 2 3 4 23
  2. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. (PMID: 15201283) Alonso A. … Mustelin T. (J. Biol. Chem. 2004) 3 4 23
  3. Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex. (PMID: 18245086) Agarwal R. … Swaminathan S. (J. Biol. Chem. 2008) 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. (PMID: 15281913) Takagaki K. … Kikuchi K. (Biochem. J. 2004) 3 4

Products for DUSP23 Gene

  • antibodies-online proteins for DUSP23
  • antibodies-online antibodies for DUSP23
  • antibodies-online kits for DUSP23

Sources for DUSP23 Gene

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