Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DUSP23 Gene

protein-coding   GIFtS: 56
GCID: GC01P159750

Dual Specificity Phosphatase 23

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dual Specificity Phosphatase 231 2     Dual Specificity Protein Phosphatase 232
Low Molecular Mass Dual Specificity Phosphatase 32 3     Low-Molecular-Mass Dual-Specificity Phosphatase 32
LDP-32 3     VH1-Like Member Z2
VHZ2 3     EC 3.1.3.163
VH1-Like Phosphatase Z2 3     EC 3.1.3.483
DUSP252     LDP33
MOSP2     

External Ids:    HGNC: 214801   Entrez Gene: 549352   Ensembl: ENSG000001587167   UniProtKB: Q9BVJ73   

Export aliases for DUSP23 gene to outside databases

Previous GC identifers: GC01P156968 GC01P156563 GC01P158017 GC01P131107


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DUSP23 Gene:
DUSP23 (dual specificity phosphatase 23) is a protein-coding gene. Diseases associated with DUSP23 include dental enamel hypoplasia, and interstitial lung disease. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7
Function: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr
residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to
enhance activation of JNK and p38 (MAPK14)

Gene Wiki entry for DUSP23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP23 gene promoter:
         SRF   Spz1   Pbx1a   AP-1   SRF (504 AA)   ATF-2   LCR-F1   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP23 promoter sequence
   Search Chromatin IP Primers for DUSP23

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.1

DUSP23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP23 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159750:  view genomic region     (about GC identifiers)

Start:
159,750,722 bp from pter      End:
159,752,333 bp from pter
Size:
1,612 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 23  
Size: 150 amino acids; 16588 Da
Caution: Was originally erroneously termed DUSP25
2 PDB 3D structures from and Proteopedia for DUSP23:
2IMG (3D)        4ERC (3D)    
Secondary accessions: Q9NX48

Explore the universe of human proteins at neXtProt for DUSP23: NX_Q9BVJ7

Explore proteomics data for DUSP23 at MOPED


See DUSP23 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060293.2  
ENSEMBL proteins: 
 ENSP00000357089   ENSP00000357088   ENSP00000357087  

DUSP23 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for DUSP23
OriGene Protein Over-expression Lysate for DUSP23
OriGene MassSpec for DUSP23
OriGene Custom Protein Services for DUSP23
GenScript Custom Purified and Recombinant Proteins Services for DUSP23
Novus Biologicals DUSP23 Proteins
Novus Biologicals DUSP23 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for DUSP23
Cloud-Clone Corp. Proteins for DUSP23

DUSP23 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for DUSP23
OriGene Custom Antibody Services for DUSP23
Novus Biologicals DUSP23 Antibodies
Abcam antibodies for DUSP23
Cloud-Clone Corp. Antibodies for DUSP23
ThermoFisher Antibodies for DUSP23
LSBio Antibodies in human, mouse, rat for DUSP23

DUSP23 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DUSP23
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DUSP23
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DUSP23
Cloud-Clone Corp. CLIAs for DUSP23


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

3 InterPro protein domains:
 IPR000387 Tyr/Dual-sp_Pase
 IPR016130 Tyr_Pase_AS
 IPR000340 Dual-sp_phosphatase_cat-dom

Graphical View of Domain Structure for InterPro Entry Q9BVJ7

ProtoNet protein and cluster: Q9BVJ7

1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain


DUSP23 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DUS23_HUMAN, Q9BVJ7
Function: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr
residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to
enhance activation of JNK and p38 (MAPK14)
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biophysicochemical properties: Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate;

     Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004725protein tyrosine phosphatase activity IEA--
GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
GO:0016791phosphatase activity ----
     
DUSP23 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for DUSP23:
 Decreased viability  Increased cell elongation  Increased cell number in S and 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP23
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP23

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP23
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP23

miRNA
Products:
    
miRTarBase miRNAs that target DUSP23:
hsa-mir-7-5p (MIRT025740), hsa-let-7b-5p (MIRT001635)

Block miRNA regulation of human, mouse, rat DUSP23 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DUSP23
SwitchGear 3'UTR luciferase reporter plasmidDUSP23 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DUSP23
Predesigned siRNA for gene silencing in human, mouse, rat DUSP23

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DUSP23

Clone
Products:
     
OriGene clones in human, mouse for DUSP23 (see all 6)
OriGene ORF clones in mouse, rat for DUSP23
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DUSP23 (NM_017823)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP23
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP23

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DUSP23
Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP23 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP23


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
DUS23_HUMAN, Q9BVJ7: Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol5
nucleus5
extracellular2
mitochondrion1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005829cytosol IEA--
GO:0043231intracellular membrane-bounded organelle ----

DUSP23 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Pathway & Disease-focused RT2 Profiler PCR Array including DUSP23: 
          Protein Phosphatases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for DUSP23

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DUSP23 (Q9BVJ72, 3 ENSP000003570874) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
InteractantInteraction Details
GeneCardExternal ID(s)
RPL8P629172, 3, ENSP000002625844MINT-65373 I2D: score=4 STRING: ENSP00000262584
C10orf118Q7Z3E22, 3, ENSP000003582934MINT-8254589 I2D: score=2 STRING: ENSP00000358293
DBIP071082, 3MINT-8254611 I2D: score=2 
DBN1Q166432, 3MINT-8254622 I2D: score=2 
DNMT3BQ9UBC32, 3MINT-8254633 I2D: score=2 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006470protein dephosphorylation ----
GO:0016311dephosphorylation ----

DUSP23 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DUSP23 (DUS23)

1 DrugBank Compound for DUSP23    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
4-Nitrophenyl Phosphate-- 330-13-2target--10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DUSP23 gene: 
NM_017823.3  

Unigene Cluster for DUSP23:

Dual specificity phosphatase 23
Hs.425801  [show with all ESTs]
Unigene Representative Sequence: BQ430655
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368109(uc001fua.1) ENST00000368108(uc001ftz.1) ENST00000368107(uc001fub.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DUSP23 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DUSP23
SwitchGear 3'UTR luciferase reporter plasmidDUSP23 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DUSP23
Predesigned siRNA for gene silencing in human, mouse, rat DUSP23
Clone
Products:
     
OriGene clones in human, mouse for DUSP23 (see all 6)
OriGene ORF clones in mouse, rat for DUSP23
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DUSP23 (NM_017823)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP23
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP23
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DUSP23
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP23
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP23
  QuantiTect SYBR Green Assays in human, mouse, rat DUSP23
  QuantiFast Probe-based Assays in human, mouse, rat DUSP23

Additional mRNA sequence: 

AB164404.1 AF086553.1 AK000449.1 BC001140.1 

6 DOTS entries:

DT.97799145  DT.112968  DT.97787382  DT.99989757  DT.100026441  DT.91826336 

Selected AceView cDNA sequences (see all 114):

AI493390 BF970174 AI831878 AB164404 BE263806 AA479435 BF221847 CB106751 
BM547541 BU785746 BC001140 BM719897 AI739584 BU157259 AF086553 BF062579 
BI761974 AA662156 AI363485 BM676758 AI915969 BU177833 BU738941 AI382796 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP23    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1:                                                
SP2:                    -                           
SP3:                                                


ECgene alternative splicing isoforms for DUSP23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DUSP23 expression in normal human tissues (normalized intensities)      DUSP23 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGTCGATGG
DUSP23 Expression
About this image


DUSP23 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)
         Oviduct
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
 
 Liver (Hepatobiliary System)
         Hepatocytes Liver Lobule
 
 Bone (Muscoskeletal System)
         Bone Marrow
DUSP23 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DUSP23 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.425801

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7
Tissue specificity: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland,
thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal
cord and stomach

    Pathway & Disease-focused RT2 Profiler PCR Array including DUSP23: 
          Protein Phosphatases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for DUSP23
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP23
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP23
QuantiTect SYBR Green Assays in human, mouse, rat DUSP23
QuantiFast Probe-based Assays in human, mouse, rat DUSP23
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP23

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP23 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dusp231 , 5 dual specificity phosphatase 231, 5 89.33(n)1
95.33(a)1
  1 (80.05 cM)5
684401  NM_026725.21  NP_081001.11 
 1726307695 
chicken
(Gallus gallus)
Aves DUSP231 dual specificity phosphatase 23 70.55(n)
66.44(a)
  100858873  XM_004948313.1  XP_004948370.1 
lizard
(Anolis carolinensis)
Reptilia DUSP236
dual specificity phosphatase 23
70(a)
1 ↔ 1
GL344296.1(37466-39681)
African clawed frog
(Xenopus laevis)
Amphibia Xl.159412 Xenopus laevis transcribed sequence with weak similarity more 72.9(n)    BX844527.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.80082 Transcribed sequence with weak similarity to protein more 76.02(n)    57073919 
fruit fly
(Drosophila melanogaster)
Insecta cdc146
cdc14
4(a)
1 → many
2L(7802415-7810697)
worm
(Caenorhabditis elegans)
Secernentea cdc-146
Protein CDC-14, isoform b
4(a)
1 → many
II(5587623-5593425) WBGene00000383
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC146
Protein phosphatase required for mitotic exit; loc...
7(a)
1 → many
VI(208413-210068) YFR028C


ENSEMBL Gene Tree for DUSP23 (if available)
TreeFam Gene Tree for DUSP23 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DUSP23 gene
CDC14A2  CDC14B2  
3 SIMAP similar genes for DUSP23 using alignment to 1 protein entry:     DUS23_HUMAN:
CDC14A    CDC14B    MGC26484

DUSP23 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for DUSP23 (see all 76)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs38061831,2
C,F,A,H--131105192(+) CCACAC/TGGAGG 1 -- us2k126Minor allele frequency- T:0.42EA NA NS WA CSA 3771
rs1904283611,2
--159748822(+) AGGGGA/CCTCAG 1 -- us2k10--------
rs38061841,2
C,F,A--159748866(+) TTCTCC/TTTCTG 1 -- us2k1 tfbs3 trp311Minor allele frequency- T:0.32WA NA CSA EA 372
rs38061851,2
C,F,A,H--159748886(+) GGCTTC/TGAGCT 1 -- us2k122Minor allele frequency- T:0.19NS EA NA WA 2756
rs1427457491,2
C--159748905(+) AGGAGA/GCAAAG 1 -- us2k10--------
rs1473804091,2
--159748908(+) AGGCAA/TAGAAG 1 -- us2k10--------
rs766151651,2
C,F--159748951(+) ACTTCC/TCTGGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs722326561,2
C--159749041(+) TGTCT-/CCAGAG
GTAGTGCAA
CCAGA
2 -- us2k1 cds10--------
rs38061861,2
C,F,A--159749110(+) GGGGTT/GGGGGG 1 -- us2k110Minor allele frequency- G:0.47NA WA CSA EA 372
rs38200991,2
C,F,A,H--159749188(+) GTAACA/CTTGAT 1 -- us2k139Minor allele frequency- C:0.35NS NA EA WA CSA 3189

HapMap Linkage Disequilibrium report for DUSP23 (159750722 - 159752333 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DUSP23: --
Human Gene Mutation Database (HGMD): DUSP23
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DUSP23
DNA2.0 Custom Variant and Variant Library Synthesis for DUSP23

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
10 diseases for DUSP23:    About MalaCards
dental enamel hypoplasia    interstitial lung disease    esophagitis    tonsillitis
adenocarcinoma    thyroiditis    lung cancer    cerebritis
prostatitis    endotheliitis

1 disease from the University of Copenhagen DISEASES database for DUSP23:
Dental enamel hypoplasia

DUSP23 for disorders           About GeneDecksing

Genetic Association Database (GAD): DUSP23
Human Genome Epidemiology (HuGE) Navigator: DUSP23 (5 documents)

Export disorders for DUSP23 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DUSP23 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with DUSP23)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. (PubMed id 15147733)1, 2, 3, 9 Wu Q....Mao Y. (Int. J. Biochem. Cell Biol. 2004)
  2. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. (PubMed id 15201283)1, 2, 9 Alonso A.... Mustelin T. (J. Biol. Chem. 2004)
  3. Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. (PubMed id 21787189)1, 4 Nyberg F....Kamatani N. (Pharmacogenomics 2011)
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  7. Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. (PubMed id 15281913)1, 2 Takagaki K....Kikuchi K. (Biochem. J. 2004)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex. (PubMed id 18245086)2, 9 Agarwal R.... Swaminathan S. (J. Biol. Chem. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 54935 HGNC: 21480 AceView: DUSP23 Ensembl:ENSG00000158716 euGenes: HUgn54935
ECgene: DUSP23 H-InvDB: DUSP23

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DUSP23 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DUSP23 gene:
Search GeneIP for patents involving DUSP23

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for DUSP23   OriGene RNAi products in human, mouse, rat for DUSP23  
 OriGene qPCR primer pairs and template standards for DUSP23   OriGene Protein Over-expression Lysate for DUSP23  
 OriGene MassSpec something-or-other for DUSP23   OriGene clones in human, mouse for DUSP23  
 OriGene qSTAR qPCR primer pairs in human, mouse for DUSP23   OriGene Purified Protein for DUSP23  
 OriGene ORF clones in mouse, rat for DUSP23   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DUSP23   OriGene Custom Protein Services for DUSP23  

 
 
 Block miRNA regulation of human, mouse, rat DUSP23 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DUSP23
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP23 Predesigned siRNA for gene silencing in human, mouse, rat DUSP23
 QuantiFast Probe-based Assays in human, mouse, rat DUSP23 QuantiTect SYBR Green Assays in human, mouse, rat DUSP23
 PCR Arrays including human, mouse, rat DUSP23 Search Chromatin IP Primers for DUSP23
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP23  Search GeneGlobe Interaction Network for DUSP23
 Regulatory tfbs in DUSP23 promoter
 GenScript Custom Purified and Recombinant Proteins Services for DUSP23 GenScript cDNA clones with any tag delivered in your preferred vector for DUSP23
 GenScript Custom Assay Services for DUSP23 GenScript Custom overexpressing Cell Line Services for DUSP23
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DUSP23 (DUS23)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DUSP23 antibodies
 DUSP23 proteins
 DUSP23 lysates
 Antibodies for DUSP23
 See all of Abcam's Antibodies, Kits and Proteins for DUSP23
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for DUSP23
 Proteins for DUSP23
 Antibodies for DUSP23
 ELISAs for DUSP23
 CLIAs for DUSP23



 Browse ESI BIO Cell Lines and PureStem Progenitors for DUSP23
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP23
 SwitchGear 3'UTR luciferase reporter plasmids for DUSP23
 SwitchGear Promoter luciferase reporter plasmids for DUSP23
 ThermoFisher Antibodies for DUSP23
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP23
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP23
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DUSP23
 LSBio Antibodies in human, mouse, rat for DUSP23
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DUSP23 gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4