Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP23 Gene

protein-coding   GIFtS: 57
GCID: GC01P159750

Dual Specificity Phosphatase 23

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 231 2     RP11-190A12.12
Low Molecular Mass Dual Specificity Phosphatase 32 3     Dual Specificity Protein Phosphatase 232
LDP-32 3     Low-Molecular-Mass Dual-Specificity Phosphatase 32
VHZ2 3     VH1-Like Member Z2
VH1-Like Phosphatase Z2 3     EC 3.1.3.163
DUSP252     EC 3.1.3.483
MOSP2     LDP33

External Ids:    HGNC: 214801   Entrez Gene: 549352   Ensembl: ENSG000001587167   UniProtKB: Q9BVJ73   

Export aliases for DUSP23 gene to outside databases

Previous GC identifers: GC01P156968 GC01P156563 GC01P158017 GC01P131107


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DUSP23 Gene: 
DUSP23 (dual specificity phosphatase 23) is a protein-coding gene. Diseases associated with DUSP23 include dental enamel hypoplasia, and esophageal adenocarcinoma. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is CDC14A.

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7
Function: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr
residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to
enhance activation of JNK and p38 (MAPK14)

Gene Wiki entry for DUSP23 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP23 gene promoter:
         SRF   Spz1   Pbx1a   AP-1   SRF (504 AA)   ATF-2   LCR-F1   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP23 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.1

DUSP23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP23 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159750:  view genomic region     (about GC identifiers)

Start:
159,750,722 bp from pter      End:
159,752,333 bp from pter
Size:
1,612 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 23  
Size: 150 amino acids; 16588 Da
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear
Caution: Was originally erroneously termed DUSP25
2 PDB 3D structures from and Proteopedia for DUSP23:
2IMG (3D)        4ERC (3D)    
Secondary accessions: Q9NX48

Explore the universe of human proteins at neXtProt for DUSP23: NX_Q9BVJ7

Explore proteomics data for DUSP23 at MOPED 

DUSP23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

DUSP23 Protein Expression

REFSEQ proteins: NP_060293.2  
ENSEMBL proteins: 
 ENSP00000357089   ENSP00000357088   ENSP00000357087  

Human Recombinant Protein Products for DUSP23: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for DUSP23
OriGene Protein Over-expression Lysate for DUSP23
OriGene MassSpec for DUSP23 
OriGene Custom Protein Services for DUSP23
GenScript Custom Purified and Recombinant Proteins Services for DUSP23
Novus Biologicals DUSP23 Proteins
Novus Biologicals DUSP23 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for DUSP23
Cloud-Clone Corp. Proteins for DUSP23 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005730NOT nucleolus IDA--
GO:0005829cytosol IEA--
GO:0043231intracellular membrane-bounded organelle IDA--

DUSP23 for ontologies           About GeneDecksing



DUSP23 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for DUSP23
OriGene Custom Antibody Services for DUSP23
GenScript Custom Superior Antibodies Services for DUSP23
Novus Biologicals DUSP23 Antibodies
Abcam antibodies for DUSP23
Cloud-Clone Corp. Antibodies for DUSP23 
ThermoFisher Antibodies for DUSP23
LSBio Antibodies in human, mouse, rat for DUSP23 

Assay Products for DUSP23: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DUSP23
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DUSP23
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for DUSP23 
Cloud-Clone Corp. CLIAs for DUSP23


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

4 InterPro protein domains:
 IPR000387 Tyr/Dual-sp_Pase
 IPR026067 Dual_phosphatase_23
 IPR016130 Tyr_Pase_AS
 IPR000340 Dual-sp_phosphatase_cat-dom

Graphical View of Domain Structure for InterPro Entry Q9BVJ7

ProtoNet protein and cluster: Q9BVJ7

1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain


DUSP23 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DUS23_HUMAN, Q9BVJ7
Function: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr
residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to
enhance activation of JNK and p38 (MAPK14)
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
Biophysicochemical properties: Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate;

     Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004725protein tyrosine phosphatase activity IEA--
GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
GO:0016791phosphatase activity ----
     
DUSP23 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for DUSP23:
 Decreased viability  Increased cell elongation  Increased cell number in S and 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP23 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP23

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DUSP23 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DUSP23 

miRNA
Products:
    
miRTarBase miRNAs that target DUSP23:
hsa-let-7b (MIRT001635)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP23
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DUSP23
SwitchGear 3'UTR luciferase reporter plasmidDUSP23 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for DUSP23
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP23

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DUSP23
Sirion Biotech Customized adenovirus for overexpression of DUSP23

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for DUSP23 (see all 7)
OriGene ORF clones in mouse, rat for DUSP23
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DUSP23 (NM_017823)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP23
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP23
Sirion Biotech Customized lentivirus for stable overexpression of DUSP23 
                     Customized lentivirus expression plasmids for stable overexpression of DUSP23 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DUSP23
Search LifeMap BioReagents cell lines for DUSP23
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP23


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP23

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/22 Interacting proteins for DUSP23 (Q9BVJ72, 3 ENSP000003570874) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
InteractantInteraction Details
GeneCardExternal ID(s)
RPL8P629172, 3, ENSP000002625844MINT-65373 I2D: score=4 STRING: ENSP00000262584
C10orf118Q7Z3E22, 3, ENSP000003582934MINT-8254589 I2D: score=2 STRING: ENSP00000358293
C10orf137Q3B7T12, 3MINT-8254600 I2D: score=2 
DBIP071082, 3MINT-8254611 I2D: score=2 
DBN1Q166432, 3MINT-8254622 I2D: score=2 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006470protein dephosphorylation ----
GO:0016311dephosphorylation ----

DUSP23 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUSP23 (DUS23)

1 DrugBank Compound for DUSP23    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
4-Nitrophenyl Phosphate-- 330-13-2target--10592235

Search CenterWatch for drugs/clinical trials and news about DUSP23 / DUS23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUSP23 gene: 
NM_017823.3  

Unigene Cluster for DUSP23:

Dual specificity phosphatase 23
Hs.425801  [show with all ESTs]
Unigene Representative Sequence: BQ430655
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368109(uc001fua.1) ENST00000368108(uc001ftz.1) ENST00000368107(uc001fub.1)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP23
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DUSP23
SwitchGear 3'UTR luciferase reporter plasmidDUSP23 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for DUSP23
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP23
Clone
Products:
     
OriGene clones in human, mouse for DUSP23 (see all 7)
OriGene ORF clones in mouse, rat for DUSP23
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DUSP23 (NM_017823)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP23
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP23
Sirion Biotech Customized lentivirus for stable overexpression of DUSP23 
                     Customized lentivirus expression plasmids for stable overexpression of DUSP23 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DUSP23
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP23
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP23
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP23
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP23

Additional mRNA sequence: 

AB164404.1 AF086553.1 AK000449.1 BC001140.1 

6 DOTS entries:

DT.97799145  DT.112968  DT.97787382  DT.99989757  DT.100026441  DT.91826336 

24/114 AceView cDNA sequences (see all 114):

AB164404 AI739584 BU785746 BF970174 BE263806 BM719897 AA662156 AI934284 
BU177833 AF086553 BM676758 CB106751 BI761974 AI382796 AI493390 AI686408 
BC001140 AA478731 BF062579 BF221847 AI223430 BU738941 BM547541 AI915969 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP23    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1:                                                
SP2:                    -                           
SP3:                                                


ECgene alternative splicing isoforms for DUSP23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUSP23 expression in normal human tissues (normalized intensities)      DUSP23 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGTCGATGG
DUSP23 Expression
About this image


DUSP23 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/25 selected tissues (see all 25) fully expand
 
 Epithelium
         vagina ; squamous epithelial cells   
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         Leydig Cells Testis Interstitium
         seminal vesicle ; glandular cells   
 
 Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
         rectum ; glandular cells   
 
 Uterus
         uterus, post-menopause ; glandular cells   
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
         lung ; macrophages   

See DUSP23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP23

SOURCE GeneReport for Unigene cluster: Hs.425801

UniProtKB/Swiss-Prot: DUS23_HUMAN, Q9BVJ7
Tissue specificity: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland,
thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal
cord and stomach

    SABiosciences Expression via Pathway-Focused PCR Array including DUSP23: 
          Protein Phosphatases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for DUSP23
OriGene qSTAR qPCR primer pairs in human, mouse for DUSP23
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP23
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP23
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP23
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP23

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for DUSP23 gene from 8/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dusp231 , 5 dual specificity phosphatase 231, 5 89.33(n)1
95.33(a)1
  1 (80.05 cM)5
684401  NM_026725.21  NP_081001.11 
 1726307695 
chicken
(Gallus gallus)
Aves LOC1008588731 dual specificity protein phosphatase 23-like 71.46(n)
67.12(a)
  100858873  XM_003642664.1  XP_003642712.1 
lizard
(Anolis carolinensis)
Reptilia DUSP236
Uncharacterized protein
70(a)
1 ↔ 1
GL344296.1(37466-39681)
African clawed frog
(Xenopus laevis)
Amphibia Xl.159412 Xenopus laevis transcribed sequence with weak similarity more 72.9(n)    BX844527.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.80082 Transcribed sequence with weak similarity to protein more 76.02(n)    57073919 
fruit fly
(Drosophila melanogaster)
Insecta cdc146
cdc14
4(a)
1 → many
2L(7802415-7810697)
worm
(Caenorhabditis elegans)
Secernentea cdc-146
Probable tyrosine-protein phosphatase cdc-14
4(a)
1 → many
II(5587623-5593427)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC146
Protein phosphatase required for mitotic exit; loc...
6(a)
1 → many
VI(208413-210068)


ENSEMBL Gene Tree for DUSP23 (if available)
TreeFam Gene Tree for DUSP23 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DUSP23 gene
CDC14A2  CDC14B2  
3 SIMAP similar genes for DUSP23 using alignment to 1 protein entry:     DUS23_HUMAN:
CDC14A    CDC14B    MGC26484

DUSP23 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/76 SNPs in DUSP23 are shown (see all 76)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs38061831,2
C,F,A,H--131105192(+) CCACAC/TGGAGG 1 -- us2k126Minor allele frequency- T:0.42EA NA NS WA CSA 3771
rs1904283611,2
--159748822(+) AGGGGA/CCTCAG 1 -- us2k10--------
rs38061841,2
C,F,A--159748866(+) TTCTCC/TTTCTG 1 -- us2k1 tfbs3 trp311Minor allele frequency- T:0.32WA NA CSA EA 372
rs38061851,2
C,F,A,H--159748886(+) GGCTTC/TGAGCT 1 -- us2k122Minor allele frequency- T:0.19NS EA NA WA 2756
rs1427457491,2
C--159748905(+) AGGAGA/GCAAAG 1 -- us2k10--------
rs1473804091,2
--159748908(+) AGGCAA/TAGAAG 1 -- us2k10--------
rs766151651,2
C,F--159748951(+) ACTTCC/TCTGGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs722326561,2
C--159749041(+) TGTCT-/CCAGAG
GTAGTGCAA
CCAGA
2 -- us2k1 cds10--------
rs38061861,2
C,F,A--159749110(+) GGGGTT/GGGGGG 1 -- us2k110Minor allele frequency- G:0.47NA WA CSA EA 372
rs38200991,2
C,F,A,H--159749188(+) GTAACA/CTTGAT 1 -- us2k139Minor allele frequency- C:0.35NS NA EA WA CSA 3189

HapMap Linkage Disequilibrium report for DUSP23 (159750722 - 159752333 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DUSP23: --

Human Gene Mutation Database (HGMD): DUSP23
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing DUSP23
DNA2.0 Custom Variant and Variant Library Synthesis for DUSP23

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
8 diseases for DUSP23:    About MalaCards
dental enamel hypoplasia    esophageal adenocarcinoma    interstitial lung disease    esophagitis
thyroiditis    adenocarcinoma    lung cancer    prostatitis

1 disease from the University of Copenhagen DISEASES database for DUSP23:
Dental enamel hypoplasia

DUSP23 for disorders           About GeneDecksing

Genetic Association Database (GAD): DUSP23
Human Genome Epidemiology (HuGE) Navigator: DUSP23 (5 documents)

Export disorders for DUSP23 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DUSP23 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with DUSP23)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. (PubMed id 15147733)1, 2, 3, 9 Wu Q....Mao Y. (2004)
  2. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. (PubMed id 15201283)1, 2, 9 Alonso A.... Mustelin T. (2004)
  3. Interstitial lung disease in gefitinib-treated Japanes e patients with non-small-cell lung cancer: genome-wide analysis of genetic data . (PubMed id 21787189)1, 4 Nyberg F....Kamatani N. (2011)
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
  5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  7. Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. (PubMed id 15281913)1, 2 Takagaki K....Kikuchi K. (2004)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  10. Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex. (PubMed id 18245086)2, 9 Agarwal R....Swaminathan S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 54935 HGNC: 21480 AceView: DUSP23 Ensembl:ENSG00000158716 euGenes: HUgn54935
ECgene: DUSP23 H-InvDB: DUSP23

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DUSP23 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DUSP23 gene:
Search GeneIP for patents involving DUSP23

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for DUSP23   OriGene RNAi products in human, mouse, rat for DUSP23  
 OriGene qPCR primer pairs and template standards for DUSP23   OriGene Protein Over-expression Lysate for DUSP23  
 OriGene MassSpec something-or-other for DUSP23   OriGene clones in human, mouse for DUSP23  
 OriGene qSTAR qPCR primer pairs in human, mouse for DUSP23   OriGene Purified Protein for DUSP23  
 OriGene ORF clones in mouse, rat for DUSP23   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DUSP23   OriGene Custom Protein Services for DUSP23  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP23
 QIAGEN SeqTarget long-range PCR primers for resequencing DUSP23
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP23
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP23
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP23
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP23
 GenScript Custom Purified and Recombinant Proteins Services for DUSP23 GenScript cDNA clones with any tag delivered in your preferred vector for DUSP23
 GenScript Custom Assay Services for DUSP23 GenScript Custom Superior Antibodies Services for DUSP23
 GenScript Custom overexpressing Cell Line Services for DUSP23 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in DUSP23 promoter
 Search Chromatin IP Primers for DUSP23
 RT2 qPCR Primer Assay in human, mouse, rat DUSP23
 Search GNC Networks for DUSP23
 SABiosciences PCR Arrays including human, mouse, rat DUSP23
 Search Tocris compounds for DUSP23 (DUS23)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 DUSP23 antibodies
 DUSP23 proteins
 DUSP23 lysates
 Antibodies for DUSP23
 See all of Abcam's Antibodies, Kits and Proteins for DUSP23
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for DUSP23




 Proteins for DUSP23
 Antibodies for DUSP23
 ELISAs for DUSP23
 CLIAs for DUSP23
 Search LifeMap BioReagents cell lines for DUSP23
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP23
 SwitchGear 3'UTR luciferase reporter plasmids for DUSP23
 SwitchGear Promoter luciferase reporter plasmids for DUSP23
 ThermoFisher Antibodies for DUSP23
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP23
 inGenious Targeting Laboratory - Custom generated mouse model solutions for DUSP23
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DUSP23
Customized:
 lentivirus for stable overexpression of DUSP23
 lentivirus expression plasmids for stable overexpression of DUSP23
 adenovirus for overexpression of DUSP23
 LSBio Antibodies in human, mouse, rat for DUSP23
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DUSP23 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4