Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP22 Gene

protein-coding   GIFtS: 56
GCID: GC06P000292

dual specificity phosphatase 22

 Explore 5 diseases affiliated with
DUSP22 via our new
 Human Malady Compendium 
Biological research products
for DUSP22
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 221 2     LMWDSP22 3
JSP11 2 3     MKP-X1
MKPX1 2 3     JNK-Stimulatory Phosphatase-12 3
JKAP1 2     MAP Kinase Phosphatase X2 3
VHX1 2     Dual Specificity Protein Phosphatase 222
Low Molecular Weight Dual Specificity Phosphatase 22 3     Homolog Of Mouse Dual Specificity Phosphatase LMW-DSP22
Mitogen-Activated Protein Kinase Phosphatase X2 3     JNK-Stimulating Phosphatase 12
JSP-12 3     EC 3.1.3.163
LMW-DSP22 3     EC 3.1.3.483

External Ids:    HGNC: 160771   Entrez Gene: 569402   Ensembl: ENSG000001126797   UniProtKB: Q9NRW43   

Export aliases for DUSP22 gene to outside databases

Previous GC identifers: GC06P000282 GC06P000237 GC06P000197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4
Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein
kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity)

Gene Wiki entry for DUSP22


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP22 gene promoter:
         AP-1   ATF-2   RelA   NF-AT   NF-AT4   NF-AT2   NF-AT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP22 promoter sequence
   Search SABiosciences Chromatin IP Primers for DUSP22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.3   Ensembl cytogenetic band:  6p25.3   HGNC cytogenetic band: 6pter-q22.33

DUSP22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP22 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P000292:  view genomic region     (about GC identifiers)

Start:
292,097 bp from pter      End:
351,355 bp from pter
Size:
59,259 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 22  
Size: 184 amino acids; 20910 Da
Subunit: Monomer
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=AAH16844.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DUSP22:
1WRM (3D)    
Secondary accessions: B4DK56 Q59GW2 Q5VWR2 Q96AR1
Alternative splicing: 2 isoforms:  Q9NRW4-1   Q9NRW4-2   

Explore the universe of human proteins at neXtProt for DUSP22: NX_Q9NRW4

Post-translational modifications:

  • Myristoylation regulates subcellular location, and is necessary for activation of JNK1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRW4

  • DUSP22 Protein expression data from MOPED and PaxDb:    About this image 
    DUSP22 Protein Expression
    REFSEQ proteins: NP_064570.1  
    ENSEMBL proteins: 
     ENSP00000345281   ENSP00000397459  

    Human Recombinant Protein Products for DUSP22: 
    EMD Millipore Purified and/or Recombinant DUSP22 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: DUSP22
    OriGene Custom Protein Services for DUSP22 
    GenScript Custom Purified and Recombinant Proteins Services for DUSP22
    Novus Biologicals DUSP22 Proteins
    Novus Biologicals DUSP22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DUSP22

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    DUSP22 for ontologies           About GeneDecksing



    DUSP22 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DUSP22 
    GenScript Custom Superior Antibodies Services for DUSP22
    Novus Biologicals DUSP22 Antibodies
    Abcam antibodies for DUSP22 
    Uscn Antibodies for DUSP22
    Search ThermoFisher Antibodies for DUSP22

    Assay Products for DUSP22: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DUSP22
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DUSP22


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DUSP22 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR020417 Atypical_DUSP
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q9NRW4

    ProtoNet protein and cluster: Q9NRW4

    1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS22_HUMAN, Q9NRW4
    Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein
    kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
         
    DUSP22 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DUSP22:
     Increased Erk phosphorylation   Increased apoptosis  Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DUSP22 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: DUSP22
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP22
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP22:
    hsa-miR-182 hsa-miR-205* hsa-miR-938 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidDUSP22 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP22 (see all 7)
    OriGene shRNA RFP: DUSP22
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP22
    Sirion Biotech Custom design and validation of potent shRNA sequences against DUSP22 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DUSP22
    Sirion Biotech Customized adenovirus for overexpression of DUSP22 
    Sirion Biotech Customized adenovirus for potent knockdown of DUSP22

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP22 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP22 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DUSP22 (NM_020185)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP22 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DUSP22
    Search LifeMap BioReagents cell lines for DUSP22
    Sirion Biotech Customized stable knockdown cell line services for DUSP22 
    Sirion Biotech Customized inducible knockdown cell line services for DUSP22
    Sirion Biotech Customized stable overexpressing cell line services for DUSP22
    Sirion Biotech Customized inducible overexpressing cell line services for DUSP22

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP22


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MAPK signaling pathway
    MAPK signaling pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for DUSP22):
        MAPK signaling pathway


    DUSP22 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for DUSP22 (Q9NRW43 ENSP000003452814) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147333, ENSP000003810664I2D: score=2 STRING: ENSP00000381066
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    MAP2K4P459853, ENSP000002624454I2D: score=1 STRING: ENSP00000262445
    MAPK14Q165393, ENSP000002297944I2D: score=1 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP16636663
    GO:0000188inactivation of MAPK activity TAS9205128
    GO:0006470protein dephosphorylation IBA--
    GO:0006915apoptotic process TAS9205128
    GO:0007179transforming growth factor beta receptor signaling pathway IBA--

    DUSP22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP22 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for DUSP22

    Browse Tocris compounds for DUSP22
    Search CenterWatch for drugs/clinical trials and news about DUSP22 / DUS22 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DUSP22 gene: 
    NM_020185.3  

    Unigene Cluster for DUSP22:

    Dual specificity phosphatase 22
    Hs.29106  [show with all ESTs]
    Unigene Representative Sequence: BX648953
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344450(uc003msx.3) ENST00000419235(uc011dhn.1 uc003msy.1)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: DUSP22
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP22
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP22:
    hsa-miR-182 hsa-miR-205* hsa-miR-938 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidDUSP22 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP22 (see all 7)
    OriGene shRNA RFP: DUSP22
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP22
    Sirion Biotech Custom design and validation of potent shRNA sequences against DUSP22 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP22 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP22 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DUSP22 (NM_020185)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP22 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP22

    Additional cDNA sequence: 

    AB208997.1 AF165519.1 AF424702.1 AK000383.1 AK074410.1 AK128760.1 AK296402.1 AK310653.1 
    AY249859.1 BC009209.2 BC016844.1 BC022847.2 BX648953.1 DQ786251.1 

    9 DOTS entries:

    DT.99935048  DT.455443  DT.101981714  DT.100790746  DT.121334683  DT.95309305  DT.91971656  DT.92002261 
    DT.95318554 

    24/165 AceView cDNA sequences (see all 165):

    BI857564 AW131859 AW167272 CB140907 AA454636 AA988584 AA406582 AA374753 
    AA285169 AI753452 AI278749 AA410304 CA453928 AI283824 AW151243 BQ225790 
    CR596349 BM128290 AA284022 AI290229 BM458295 BU181268 CD238656 AW207369 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP22 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10
    SP1:                    -     -     -                                   -     -           -     -     -         
    SP2:                    -     -     -                                   -     -                                 
    SP3:                    -     -     -                                                                           
    SP4:                    -     -     -     -                             -     -                                 
    SP5:              -     -     -     -                                   -     -                                 


    ECgene alternative splicing isoforms for DUSP22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTGCTTTTG
    DUSP22 Expression
    About this image
    See DUSP22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP22

    SOURCE GeneReport for Unigene cluster: Hs.29106

    UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4
    Tissue specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including DUSP22: 
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DUSP22
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP22
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP22 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DUSP221 dual specificity phosphatase 22 78.82(n)
    84.71(a)
      420887  XM_418974.2  XP_418974.2 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP226
    --
    82(a)
    1 ↔ 1
    GL343247.1(841887-864491)
    zebrafish
    (Danio rerio)
    Actinopterygii dusp22b1 dual specificity phosphatase 22b 66.27(n)
    65.68(a)
      100002272  NM_001017742.2  NP_001017742.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100891 CG10089 57.63(n)
    51.81(a)
      39517  NM_140397.1  NP_648654.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.26
    Protein C16A3.2
    20(a)
    possible ortholog
    III(6389780-6390785)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MKP26
    DSPTP16
    dual specificity protein phosphatase 1
    31(a)
    24(a)
    many ↔ many
    many ↔ many
    3(1843413-1845014)
    3(8478122-8479857)
    rice
    (Oryza sativa)
    Liliopsida --
    dual specificity protein phosphatase, putative, ex...
    29(a)
    1 → many
    1(16510500-16517634)


    ENSEMBL Gene Tree for DUSP22 (if available)
    TreeFam Gene Tree for DUSP22 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP22 gene
    DUSP152  DUSP122  STYX2  
    15 SIMAP similar genes for DUSP22 using alignment to 2 protein entries:     DUS22_HUMAN (see all proteins):
    DUSP15    DUSP10    DUSP8    DUSP7    DUSP6    DUSP16
    STYX    DUSP9    SSH2    DUSP19    DUSP18    DUSP28
    SSH1    SSH3    DUPD1

    DUSP22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/941 NCBI SNPs in DUSP22 are shown (see all 941    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168306811,2
    --290159(+) TAGGCC/TATACT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1814010031,2
    --290255(+) ATCTAC/TAAGAA 1 -- us2k10--------
    rs759080721,2
    C,F--290438(+) GTTGCT/CGGATA 1 -- us2k12Minor allele frequency- C:0.05NA EA 240
    rs1414564611,2
    --290498(+) AAAGCC/TAGCTC 1 -- us2k10--------
    rs1855381131,2
    --290580(+) GGCAGC/TCCACT 1 -- us2k10--------
    rs1508574411,2
    --290801(+) CAAGCC/GCATAT 1 -- us2k10--------
    rs1899997571,2
    --290827(+) TACACA/GGGGGG 1 -- us2k10--------
    rs18490441,2
    C,F,H--290895(-) GTAGAC/TTCCAT 1 -- us2k110Minor allele frequency- T:0.13NS EA WA NA CSA 664
    rs1385688911,2
    --290906(+) AAGCTC/GTTTCC 1 -- us2k10--------
    rs558697431,2
    F--290951(+) CTCGGC/TCACAA 1 -- us2k11Minor allele frequency- T:0.11NA 120

    HapMap Linkage Disequilibrium report for DUSP22 (292097 - 351355 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for DUSP22
         14 CNVs: 64407 1121 32769 8505 7550 93425 2614 64406 53734 0284 4483 37847 31265 3593

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP22
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DUSP22 for disorders           About GeneDecksing

    5 diseases for DUSP22:    About MalaCards
    duane retraction syndrome    multiple epiphyseal dysplasia    anaplastic large cell lymphoma    epiphyseal dysplasia
    malaria

    1 disease from the University of Copenhagen DISEASES database for DUSP22:
    Duane retraction syndrome

    Export disorders for DUSP22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP22 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with DUSP22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. (PubMed id 11717427)1, 2, 3 Shen Y....Tonks N.K. (2001)
    2. Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution. (PubMed id 17068812)1, 2 Yokota T....Sugio S. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3 Smith A....Ashworth A. (1997)
    7. JNK pathway-associated phosphatase dephosphorylates f ocal adhesion kinase and suppresses cell migration. (PubMed id 20018849)1, 9 Li J.P....Tan T.H. (2010)
    8. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. (PubMed id 17384676)1, 9 Sekine Y....Matsuda T. (2007)
    9. Hypomethylation of dual specificity phosphatase 22 pro moter correlates with duration of service in firefighters and is inducible by lo w-dose benzo[a]pyrene. (PubMed id 22796920)1 Ouyang B....Ho S.M. (2012)
    10. Discovery of recurrent t(6;7)(p25.3;q32.3) translocat ions in ALK-negative anaplastic large cell lymphomas by massively parallel geno mic sequencing. (PubMed id 21030553)1 Feldman A.L....Vasmatzis G. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56940 HGNC: 16077 AceView: DUSP22 Ensembl:ENSG00000112679 euGenes: HUgn56940
    ECgene: DUSP22 Kegg: 56940 H-InvDB: DUSP22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP22 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DUSP22 gene:
    Search GeneIP for patents involving DUSP22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore Purified and/or Recombinant DUSP22 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DUSP22  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP22   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP22  
     OriGene Protein Over-expression Lysate for DUSP22   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for DUSP22  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP22   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP22  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DUSP22   OriGene Custom Protein Services for DUSP22  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP22
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP22
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP22
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP22
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP22
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP22
     GenScript Custom Purified and Recombinant Proteins Services for DUSP22 GenScript cDNA clones with any tag delivered in your preferred vector for DUSP22
     GenScript Custom Assay Services for DUSP22 GenScript Custom Superior Antibodies Services for DUSP22
     GenScript Custom overexpressing Cell Line Services for DUSP22 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DUSP22 promoter
     Search Chromatin IP Primers for DUSP22
     RT2 qPCR Primer Assay in human, mouse, rat DUSP22
     GNC Network for DUSP22
     SABiosciences PCR Arrays including human, mouse, rat DUSP22
     Search Tocris compounds for DUSP22
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for DUSP22
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DUSP22 antibodies
     DUSP22 proteins
     DUSP22 lysates
     Antibodies for DUSP22
     See all of Abcam's Antibodies, Kits and Proteins for DUSP22
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DUSP22 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DUSP22
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP22
     SwitchGear 3'UTR luciferase reporter plasmids for DUSP22
     SwitchGear Promoter luciferase reporter plasmids for DUSP22
     Search ThermoFisher Antibodies for DUSP22
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP22
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DUSP22
    Sirion Biotech Customized:
     stable knockdown cell line services for DUSP22
     inducible knockdown cell line services for DUSP22
     design and validation of potent shRNA sequences against DUSP22
     adenovirus for potent knockdown of DUSP22
     adenovirus for overexpression of DUSP22
     stable overexpressing cell line services for DUSP22
     inducible overexpressing cell line services for DUSP22
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DUSP22 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4