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DUSP22 Gene

protein-coding   GIFtS: 56
GCID: GC06P000292

Dual Specificity Phosphatase 22

  See DUSP22-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 221 2     JNK-Stimulatory Phosphatase-12 3
Low Molecular Weight Dual Specificity Phosphatase 22 3     MAP Kinase Phosphatase X2 3
Mitogen-Activated Protein Kinase Phosphatase X2 3     JKAP2
JSP-12 3     VHX2
JSP12 3     Dual Specificity Protein Phosphatase 222
LMW-DSP22 3     Homolog Of Mouse Dual Specificity Phosphatase LMW-DSP22
LMWDSP22 3     JNK-Stimulating Phosphatase 12
MKP-x2 3     EC 3.1.3.163
MKPX2 3     EC 3.1.3.483

External Ids:    HGNC: 160771   Entrez Gene: 569402   Ensembl: ENSG000001126797   UniProtKB: Q9NRW43   

Export aliases for DUSP22 gene to outside databases

Previous GC identifers: GC06P000282 GC06P000237 GC06P000197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DUSP22 Gene:
DUSP22 (dual specificity phosphatase 22) is a protein-coding gene. Diseases associated with DUSP22 include alk-negative anaplastic large cell lymphoma, and duane retraction syndrome. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4
Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein
kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity)

Gene Wiki entry for DUSP22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP22 gene promoter:
         AP-1   ATF-2   RelA   NF-AT   NF-AT4   NF-AT2   NF-AT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP22 promoter sequence
   Search Chromatin IP Primers for DUSP22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.3   Ensembl cytogenetic band:  6p25.3   HGNC cytogenetic band: 6p25.3

DUSP22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP22 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P000292:  view genomic region     (about GC identifiers)

Start:
291,630 bp from pter      End:
351,355 bp from pter
Size:
59,726 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 22  
Size: 184 amino acids; 20910 Da
Subunit: Monomer
Sequence caution: Sequence=AAH16844.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DUSP22:
1WRM (3D)    
Secondary accessions: B4DK56 Q59GW2 Q5VWR2 Q96AR1
Alternative splicing: 2 isoforms:  Q9NRW4-1   Q9NRW4-2   

Explore the universe of human proteins at neXtProt for DUSP22: NX_Q9NRW4

Explore proteomics data for DUSP22 at MOPED

Post-translational modifications: 

  • Myristoylation regulates subcellular location, and is necessary for activation of JNK1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273484.1  NP_064570.1  

    ENSEMBL proteins: 
     ENSP00000474082   ENSP00000345281   ENSP00000474646   ENSP00000474827   ENSP00000474450  
     ENSP00000475106   ENSP00000397459   ENSP00000475061   ENSP00000474000   ENSP00000474330  
     ENSP00000474505  

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    Cloud-Clone Corp. Proteins for DUSP22

     
    Search eBioscience for Proteins for DUSP22 

     
    antibodies-online proteins for DUSP22 (7 products) 

     
    Search antibodies-online for peptides for DUSP22

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    5 InterPro protein domains:
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR020417 Atypical_DUSP
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q9NRW4

    ProtoNet protein and cluster: Q9NRW4

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS22_HUMAN, Q9NRW4
    Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein
    kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with DUSP22           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DUSP22:
     Increased Erk phosphorylation   Increased apoptosis  Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DUSP22

    miRNA
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    miRTarBase miRNAs that target DUSP22:
    hsa-mir-26b-5p (MIRT030306), hsa-mir-335-5p (MIRT019217)

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    5 qRT-PCR Assays for microRNAs that regulate DUSP22:
    hsa-miR-182 hsa-miR-205* hsa-miR-938 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidDUSP22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DUSP22
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP22

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP22

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS22_HUMAN, Q9NRW4: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DUSP22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP22: 
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DUSP22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for DUSP22 (Q9NRW43 ENSP000003452814) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147333, ENSP000003810664I2D: score=2 STRING: ENSP00000381066
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    MAPK8P459833, ENSP000003534834I2D: score=2 STRING: ENSP00000353483
    MAP2K4P459853, ENSP000002624454I2D: score=1 STRING: ENSP00000262445
    MAPK14Q165393, ENSP000002297944I2D: score=1 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP16636663
    GO:0000188inactivation of MAPK activity TAS9205128
    GO:0006470protein dephosphorylation IBA--
    GO:0006915apoptotic process TAS9205128
    GO:0007179transforming growth factor beta receptor signaling pathway IBA--

    Find genes that share ontologies with DUSP22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DUSP22
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP22 (DUS22)



    Find genes that share compounds with DUSP22           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP22 gene (2 alternative transcripts): 
    NM_001286555.1  NM_020185.4  

    Unigene Cluster for DUSP22:

    Dual specificity phosphatase 22
    Hs.29106  [show with all ESTs]
    Unigene Representative Sequence: BX648953
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603296 ENST00000344450(uc003msx.3) ENST00000603453 ENST00000605315
    ENST00000603881 ENST00000603795 ENST00000419235(uc011dhn.1 uc003msy.1)
    ENST00000605035 ENST00000605863 ENST00000603005 ENST00000603726 ENST00000603290
    ENST00000605391 ENST00000604971 ENST00000604914 ENST00000604988
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate DUSP22:
    hsa-miR-182 hsa-miR-205* hsa-miR-938 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidDUSP22 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DUSP22

    Additional mRNA sequence: 

    AB208997.1 AF165519.1 AF424702.1 AK000383.1 AK074410.1 AK128760.1 AK296402.1 AK310653.1 
    AY249859.1 BC009209.2 BC016844.1 BC022847.2 BX648953.1 DQ786251.1 

    9 DOTS entries:

    DT.99935048  DT.455443  DT.101981714  DT.100790746  DT.121334683  DT.95309305  DT.91971656  DT.92002261 
    DT.95318554 

    Selected AceView cDNA sequences (see all 165):

    N36626 AA406582 AA769207 CD238656 AA456248 AI024730 H91337 AI283824 
    AI278749 BM128290 AW151243 CR596349 BQ225790 AW131859 BU181268 AA410304 
    BM458295 AA285169 AA345748 BQ025957 AW167272 AW207369 AI753452 CB140907 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DUSP22 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10
    SP1:                    -     -     -                                   -     -           -     -     -         
    SP2:                    -     -     -                                   -     -                                 
    SP3:                    -     -     -                                                                           
    SP4:                    -     -     -     -                             -     -                                 
    SP5:              -     -     -     -                                   -     -                                 


    ECgene alternative splicing isoforms for DUSP22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCTTTTG
    DUSP22 Expression
    About this image


    DUSP22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    DUSP22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29106

    UniProtKB/Swiss-Prot: DUS22_HUMAN, Q9NRW4
    Tissue specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including DUSP22: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DUSP22 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp221 , 5 dual specificity phosphatase 221, 5 87.32(n)1
    90.73(a)1
      13 (13.26 cM)5
    1053521  NM_001037955.41  NP_001033044.11 
     306599995 
    chicken
    (Gallus gallus)
    Aves DUSP221 dual specificity phosphatase 22 74.96(n)
    78.54(a)
      420887  XM_418974.2  XP_418974.2 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP226
    dual specificity phosphatase 22
    66(a)
    1 ↔ 1
    GL343247.1(837089-879278)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dusp221 dual specificity phosphatase 22 69.11(n)
    71.22(a)
      496452  NM_001011043.2  NP_001011043.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp22b1 dual specificity phosphatase 22b 65.38(n)
    62.98(a)
      100002272  NM_001017742.2  NP_001017742.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100891 CG10089 57.66(n)
    51.15(a)
      39517  NM_140397.2  NP_648654.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C16A3.26
    Protein C16A3.2 (C16A3.2) mRNA, complete cds
    22(a)
    1 → many
    III(6389833-6390838) WBGene00015807


    ENSEMBL Gene Tree for DUSP22 (if available)
    TreeFam Gene Tree for DUSP22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP22 gene
    DUSP262  DUSP212  DUPD12  DUSP32  DUSP132  DUSP272  STYX2  DUSP142  
    DUSP192  DUSP282  DUSP152  DUSP182  
    15 SIMAP similar genes for DUSP22 using alignment to 6 protein entries:     DUS22_HUMAN (see all proteins):
    DUSP15    DUSP10    DUSP8    DUSP7    DUSP6    DUSP16
    DUSP9    STYX    SSH2    DUSP19    DUSP13    DUSP18
    DUSP28    SSH1    SSH3

    Find genes that share paralogs with DUSP22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP22 (see all 1148)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168306811,2
    F--290159(+) TAGGCC/TATACT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1122139931,2
    C--290217(+) TTAGGG/TGGAAA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1814010031,2
    --290255(+) ATCTAC/TAAGAA 1 -- us2k10--------
    rs759080721,2
    C,F--290438(+) GTTGCT/CGGATA 1 -- us2k12Minor allele frequency- C:0.05NA EA 240
    rs1414564611,2
    C--290498(+) AAAGCC/TAGCTC 1 -- us2k10--------
    rs1855381131,2
    --290580(+) GGCAGC/TCCACT 1 -- us2k10--------
    rs1508574411,2
    --290801(+) CAAGCC/GCATAT 1 -- us2k10--------
    rs1899997571,2
    --290827(+) TACACA/GGGGGG 1 -- us2k10--------
    rs18490441,2
    C,F,H--290895(-) GTAGAC/TTCCAT 1 -- us2k110Minor allele frequency- T:0.13NS EA WA NA CSA 664
    rs1385688911,2
    C--290906(+) AAGCTC/GTTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUSP22 (291630 - 351355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DUSP22 (see all 58):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv995174CNV Deletion20482838
    nsv820552CNV Duplication20802225
    esv2421645CNV Duplication20811451
    esv2421434CNV Duplication20811451
    esv1057238CNV Insertion17803354
    nsv5166CNV Insertion18451855
    nsv5164CNV Insertion18451855
    nsv437476CNV Loss16327808
    nsv524816CNV Loss19592680
    esv998752CNV Loss20482838

    Human Gene Mutation Database (HGMD): DUSP22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DUSP22
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for DUSP22:    
    About MalaCards
    alk-negative anaplastic large cell lymphoma    duane retraction syndrome

    1 disease from the University of Copenhagen DISEASES database for DUSP22:
    Duane retraction syndrome

    Find genes that share disorders with DUSP22           About GenesLikeMe

    Genetic Association Database (GAD): DUSP22

    Export disorders for DUSP22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP22 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with DUSP22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. (PubMed id 11717427)1, 2, 3 Shen Y.... Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution. (PubMed id 17068812)1, 2 Yokota T....Sugio S. (Proteins 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PubMed id 9205128)1, 3 Smith A....Ashworth A. (Genomics 1997)
    7. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. (PubMed id 20018849)1, 9 Li J.P....Tan T.H. (J. Biol. Chem. 2010)
    8. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. (PubMed id 17384676)1, 9 Sekine Y....Matsuda T. (Oncogene 2007)
    9. Primary cutaneous CD30-positive T-cell lymphoproliferative disorders with biallelic rearrangements of DUSP22. (PubMed id 23337887)1 Csikesz C.R....Kadin M. (J. Invest. Dermatol. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56940 HGNC: 16077 AceView: DUSP22 Ensembl:ENSG00000112679 euGenes: HUgn56940
    ECgene: DUSP22 H-InvDB: DUSP22

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DUSP22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DUSP22 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DUSP22 gene:
    Search GeneIP for patents involving DUSP22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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