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Aliases for DUSP22 Gene

Aliases for DUSP22 Gene

  • Dual Specificity Phosphatase 22 2 3
  • Low Molecular Weight Dual Specificity Phosphatase 2 3 4
  • Mitogen-Activated Protein Kinase Phosphatase X 3 4
  • JNK-Stimulatory Phosphatase-1 3 4
  • MAP Kinase Phosphatase X 3 4
  • LMW-DSP2 3 4
  • LMWDSP2 3 4
  • JSP-1 3 4
  • MKP-X 3 4
  • JSP1 3 4
  • MKPX 3 4
  • Homolog Of Mouse Dual Specificity Phosphatase LMW-DSP2 3
  • Dual Specificity Protein Phosphatase 22 3
  • JNK-Stimulating Phosphatase 1 3
  • EC 4
  • EC 4
  • JKAP 3
  • VHX 3

External Ids for DUSP22 Gene

Previous GeneCards Identifiers for DUSP22 Gene

  • GC06P000282
  • GC06P000237
  • GC06P000197

Summaries for DUSP22 Gene

GeneCards Summary for DUSP22 Gene

DUSP22 (Dual Specificity Phosphatase 22) is a Protein Coding gene. Diseases associated with DUSP22 include alk-negative anaplastic large cell lymphoma and duane retraction syndrome. GO annotations related to this gene include protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for DUSP22 Gene

  • Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Gene Wiki entry for DUSP22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP22 Gene

Genomics for DUSP22 Gene

Regulatory Elements for DUSP22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP22 Gene

291,630 bp from pter
351,355 bp from pter
59,726 bases
Plus strand

Genomic View for DUSP22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP22 Gene

Proteins for DUSP22 Gene

  • Protein details for DUSP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 22
    Protein Accession:
    Secondary Accessions:
    • B4DK56
    • Q59GW2
    • Q5VWR2
    • Q96AR1

    Protein attributes for DUSP22 Gene

    184 amino acids
    Molecular mass:
    20910 Da
    Quaternary structure:
    • Monomer.
    • Sequence=AAH16844.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP22 Gene

    Alternative splice isoforms for DUSP22 Gene


neXtProt entry for DUSP22 Gene

Proteomics data for DUSP22 Gene at MOPED

Post-translational modifications for DUSP22 Gene

  • Myristoylation regulates subcellular location, and is necessary for activation of JNK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DUSP22 Gene

Domains for DUSP22 Gene

Gene Families for DUSP22 Gene

  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUSP22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NRW4
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP22: view

Function for DUSP22 Gene

Molecular function for DUSP22 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Enzyme Numbers (IUBMB) for DUSP22 Gene

Gene Ontology (GO) - Molecular Function for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with DUSP22: view
genes like me logo Genes that share phenotypes with DUSP22: view

Animal Model Products

miRNA for DUSP22 Gene

miRTarBase miRNAs that target DUSP22

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP22

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP22 Gene

Localization for DUSP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP22 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DUSP22 Gene COMPARTMENTS Subcellular localization image for DUSP22 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUSP22: view

Pathways for DUSP22 Gene

SuperPathways for DUSP22 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 16636663
GO:0000188 inactivation of MAPK activity TAS 9205128
GO:0006470 protein dephosphorylation IBA --
GO:0006915 apoptotic process TAS 9205128
GO:0007179 transforming growth factor beta receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with DUSP22: view

No data available for Pathways by source for DUSP22 Gene

Compounds for DUSP22 Gene

No Compound Related Data Available

Transcripts for DUSP22 Gene

Unigene Clusters for DUSP22 Gene

Dual specificity phosphatase 22:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - - - - - -

Relevant External Links for DUSP22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP22 Gene

mRNA expression in normal human tissues for DUSP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DUSP22 Gene

This gene is overexpressed in Pancreatic juice (33.7), Peripheral blood mononuclear cells (12.8), and Bone (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP22 Gene

SOURCE GeneReport for Unigene cluster for DUSP22 Gene Hs.29106

mRNA Expression by UniProt/SwissProt for DUSP22 Gene

Tissue specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
genes like me logo Genes that share expressions with DUSP22: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for DUSP22 Gene

Orthologs for DUSP22 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP22 35
  • 83.74 (n)
  • 88.29 (a)
DUSP22 36
  • 76 (a)
(Canis familiaris)
Mammalia DUSP22 35
  • 89.48 (n)
  • 92.51 (a)
DUSP22 36
  • 86 (a)
(Mus musculus)
Mammalia Dusp22 35
  • 87.32 (n)
  • 90.73 (a)
Dusp22 16
Dusp22 36
  • 79 (a)
(Pan troglodytes)
Mammalia DUSP22 35
  • 99.19 (n)
  • 99.39 (a)
DUSP22 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Dusp22 35
  • 88.82 (n)
  • 91.18 (a)
(Monodelphis domestica)
Mammalia DUSP22 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia DUSP22 36
  • 92 (a)
(Gallus gallus)
Aves DUSP22 35
  • 74.96 (n)
  • 78.54 (a)
DUSP22 36
  • 70 (a)
(Anolis carolinensis)
Reptilia DUSP22 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp22 35
  • 69.11 (n)
  • 71.22 (a)
(Danio rerio)
Actinopterygii dusp22b 35
  • 65.38 (n)
  • 62.98 (a)
dusp22b 36
  • 61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.830 35
fruit fly
(Drosophila melanogaster)
Insecta CG10089 35
  • 57.66 (n)
  • 51.15 (a)
CG10089 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C16A3.2 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9033 36
  • 40 (a)
Species with no ortholog for DUSP22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP22 Gene

Gene Tree for DUSP22 (if available)
Gene Tree for DUSP22 (if available)

Paralogs for DUSP22 Gene

genes like me logo Genes that share paralogs with DUSP22: view

Variants for DUSP22 Gene

Sequence variations from dbSNP and Humsavar for DUSP22 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9505 -- 350,496(+) TTCCT(A/G)TGCAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs707904 -- 293,564(-) CCACA(C/T)TGCCA intron-variant
rs733787 -- 301,312(+) TTTAG(A/G)GCAAA intron-variant
rs746308 -- 306,406(+) ACAAG(C/T)TATAC intron-variant
rs815566 -- 315,051(+) GATGC(A/G)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP22 Gene

Variant ID Type Subtype PubMed ID
dgv1885e1 CNV Complex 17122850
dgv1886e1 CNV Complex 17122850
nsv428134 CNV Gain 18775914
esv581 CNV CNV 17122850
dgv1887e1 CNV Complex 17122850
esv2752087 CNV Gain 17911159
nsv821644 CNV Gain 15273396
dgv1888e1 CNV Complex 17122850
dgv1889e1 CNV Complex 17122850
nsv830568 CNV Gain+Loss 17160897
dgv1890e1 CNV Complex 17122850
esv32812 CNV Loss 17666407
nsv462600 CNV Loss 19166990
dgv1891e1 CNV Complex 17122850
dgv736n27 CNV Loss 19166990
dgv6411n71 CNV Gain 21882294
dgv6412n71 CNV Gain+Loss 21882294
dgv6413n71 CNV Gain 21882294
dgv6414n71 CNV Loss 21882294
nsv820552 CNV Duplication 20802225
dgv990n67 CNV Gain 20364138
esv28111 CNV Gain+Loss 19812545
nsv10799 CNV Gain+Loss 18304495
dgv6415n71 CNV Gain+Loss 21882294
dgv6416n71 CNV Gain 21882294
dgv6417n71 CNV Gain 21882294
nsv514340 CNV Gain 21397061
esv2421434 CNV Duplication 20811451
esv998752 CNV Loss 20482838
nsv442973 CNV CNV 18776908
dgv1892e1 CNV Complex 17122850
dgv1893e1 CNV Complex 17122850
dgv1894e1 CNV Complex 17122850
esv29987 CNV Loss 17803354
dgv1895e1 CNV Complex 17122850
nsv524816 CNV Loss 19592680
dgv6418n71 CNV Gain 21882294
nsv525541 CNV Gain 19592680
dgv991n67 CNV Gain 20364138
nsv883345 CNV Gain 21882294
nsv823390 CNV Gain 20364138
nsv883346 CNV Gain 21882294
esv2421645 CNV Duplication 20811451
essv24628 CNV CNV 17122850
dgv1896e1 CNV Complex 17122850
essv23730 CNV CNV 17122850
nsv5164 CNV Insertion 18451855
nsv883347 CNV Gain 21882294
dgv6419n71 CNV Loss 21882294
dgv6420n71 CNV Gain 21882294
dgv6421n71 CNV Loss 21882294
esv1057238 CNV Insertion 17803354
nsv349805 CNV Loss 16902084
esv995174 CNV Deletion 20482838
nsv883355 CNV Gain+Loss 21882294
nsv883357 CNV Gain+Loss 21882294
nsv437476 CNV Loss 16327808
nsv5166 CNV Insertion 18451855

Relevant External Links for DUSP22 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP22 Gene

Disorders for DUSP22 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DUSP22 Gene in MalaCards »

(2) Diseases for DUSP22 Gene including...

(1) University of Copenhagen DISEASES for DUSP22 Gene

Relevant External Links for DUSP22

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DUSP22: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for DUSP22 Gene

Publications for DUSP22 Gene

  1. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. (PMID: 11717427) Shen Y. … Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution. (PMID: 17068812) Yokota T. … Sugio S. (Proteins 2007) 3 4
  5. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. (PMID: 17384676) Sekine Y. … Matsuda T. (Oncogene 2007) 3 23

Products for DUSP22 Gene

Sources for DUSP22 Gene

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