Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUSP22 Gene

Aliases for DUSP22 Gene

  • Dual Specificity Phosphatase 22 2 3 5
  • Low Molecular Weight Dual Specificity Phosphatase 2 3 4
  • Mitogen-Activated Protein Kinase Phosphatase X 3 4
  • JNK-Stimulatory Phosphatase-1 3 4
  • MAP Kinase Phosphatase X 3 4
  • LMW-DSP2 3 4
  • LMWDSP2 3 4
  • JSP-1 3 4
  • MKP-X 3 4
  • JSP1 3 4
  • MKPX 3 4
  • Homolog Of Mouse Dual Specificity Phosphatase LMW-DSP2 3
  • JNK-Stimulating Phosphatase 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • JKAP 3
  • VHX 3

External Ids for DUSP22 Gene

Previous GeneCards Identifiers for DUSP22 Gene

  • GC06P000282
  • GC06P000237
  • GC06P000197

Summaries for DUSP22 Gene

GeneCards Summary for DUSP22 Gene

DUSP22 (Dual Specificity Phosphatase 22) is a Protein Coding gene. Diseases associated with DUSP22 include lymphatic system cancer. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

UniProtKB/Swiss-Prot for DUSP22 Gene

  • Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Gene Wiki entry for DUSP22 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP22 Gene

Genomics for DUSP22 Gene

Regulatory Elements for DUSP22 Gene

Promoters for DUSP22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP22 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP22 Gene

Chromosome:
6
Start:
291,630 bp from pter
End:
351,355 bp from pter
Size:
59,726 bases
Orientation:
Plus strand

Genomic View for DUSP22 Gene

Genes around DUSP22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP22 Gene

Proteins for DUSP22 Gene

  • Protein details for DUSP22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRW4-DUS22_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 22
    Protein Accession:
    Q9NRW4
    Secondary Accessions:
    • B4DK56
    • Q59GW2
    • Q5VWR2
    • Q96AR1

    Protein attributes for DUSP22 Gene

    Size:
    184 amino acids
    Molecular mass:
    20910 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH16844.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DUSP22 Gene

    Alternative splice isoforms for DUSP22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP22 Gene

Proteomics data for DUSP22 Gene at MOPED

Post-translational modifications for DUSP22 Gene

  • Myristoylation regulates subcellular location, and is necessary for activation of JNK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DUSP22 Gene

Domains & Families for DUSP22 Gene

Gene Families for DUSP22 Gene

Suggested Antigen Peptide Sequences for DUSP22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRW4

UniProtKB/Swiss-Prot:

DUS22_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP22: view

Function for DUSP22 Gene

Molecular function for DUSP22 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Enzyme Numbers (IUBMB) for DUSP22 Gene

Gene Ontology (GO) - Molecular Function for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP22: view
genes like me logo Genes that share phenotypes with DUSP22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP22

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP22 Gene

Localization for DUSP22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP22 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP22 Gene COMPARTMENTS Subcellular localization image for DUSP22 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP22 Gene

Pathways & Interactions for DUSP22 Gene

SuperPathways for DUSP22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 9205128
GO:0002710 negative regulation of T cell mediated immunity IEA --
GO:0006470 protein dephosphorylation IEA,TAS 9205128
GO:0006915 apoptotic process TAS 9205128
GO:0007179 transforming growth factor beta receptor signaling pathway IEA,IBA --
genes like me logo Genes that share ontologies with DUSP22: view

No data available for Pathways by source and SIGNOR curated interactions for DUSP22 Gene

Drugs & Compounds for DUSP22 Gene

(2) Additional Compounds for DUSP22 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP22: view

Transcripts for DUSP22 Gene

Unigene Clusters for DUSP22 Gene

Dual specificity phosphatase 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - - - - - -

Relevant External Links for DUSP22 Gene

GeneLoc Exon Structure for
DUSP22
ECgene alternative splicing isoforms for
DUSP22

Expression for DUSP22 Gene

mRNA expression in normal human tissues for DUSP22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP22 Gene

This gene is overexpressed in Pancreatic juice (33.7), Peripheral blood mononuclear cells (12.8), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP22 Gene



SOURCE GeneReport for Unigene cluster for DUSP22 Gene Hs.29106

mRNA Expression by UniProt/SwissProt for DUSP22 Gene

Q9NRW4-DUS22_HUMAN
Tissue specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with DUSP22: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DUSP22 Gene

Orthologs for DUSP22 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP22 35
  • 83.74 (n)
  • 88.29 (a)
DUSP22 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP22 35
  • 89.48 (n)
  • 92.51 (a)
DUSP22 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp22 35
  • 87.32 (n)
  • 90.73 (a)
Dusp22 16
Dusp22 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP22 35
  • 99.19 (n)
  • 99.39 (a)
DUSP22 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp22 35
  • 88.82 (n)
  • 91.18 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP22 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP22 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP22 35
  • 74.96 (n)
  • 78.54 (a)
DUSP22 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP22 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp22 35
  • 69.11 (n)
  • 71.22 (a)
zebrafish
(Danio rerio)
Actinopterygii dusp22b 35
  • 65.38 (n)
  • 62.98 (a)
dusp22b 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.830 35
fruit fly
(Drosophila melanogaster)
Insecta CG10089 35
  • 57.66 (n)
  • 51.15 (a)
CG10089 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C16A3.2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9033 36
  • 40 (a)
OneToMany
Species with no ortholog for DUSP22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP22 Gene

ENSEMBL:
Gene Tree for DUSP22 (if available)
TreeFam:
Gene Tree for DUSP22 (if available)

Paralogs for DUSP22 Gene

genes like me logo Genes that share paralogs with DUSP22: view

Variants for DUSP22 Gene

Sequence variations from dbSNP and Humsavar for DUSP22 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7768224 - 348,195(+) CGTGC(A/G)TGCTG nc-transcript-variant, reference, missense
rs9505 -- 350,496(+) TTCCT(A/G)TGCAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs733787 -- 301,312(+) TTTAG(A/G)GCAAA intron-variant
rs746308 -- 306,406(+) ACAAG(C/T)TATAC intron-variant
rs815566 -- 315,051(+) GATGC(A/G)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP22 Gene

Variant ID Type Subtype PubMed ID
dgv1885e1 CNV Complex 17122850
dgv1886e1 CNV Complex 17122850
nsv428134 CNV Gain 18775914
esv581 CNV CNV 17122850
dgv1887e1 CNV Complex 17122850
esv2752087 CNV Gain 17911159
nsv821644 CNV Gain 15273396
dgv1888e1 CNV Complex 17122850
dgv1889e1 CNV Complex 17122850
nsv830568 CNV Gain+Loss 17160897
dgv1890e1 CNV Complex 17122850
esv32812 CNV Loss 17666407
nsv462600 CNV Loss 19166990
dgv1891e1 CNV Complex 17122850
dgv736n27 CNV Loss 19166990
dgv6411n71 CNV Gain 21882294
dgv6412n71 CNV Gain+Loss 21882294
dgv6413n71 CNV Gain 21882294
dgv6414n71 CNV Loss 21882294
nsv820552 CNV Duplication 20802225
dgv990n67 CNV Gain 20364138
esv28111 CNV Gain+Loss 19812545
nsv10799 CNV Gain+Loss 18304495
dgv6415n71 CNV Gain+Loss 21882294
dgv6416n71 CNV Gain 21882294
dgv6417n71 CNV Gain 21882294
nsv514340 CNV Gain 21397061
esv2421434 CNV Duplication 20811451
esv998752 CNV Loss 20482838
nsv442973 CNV CNV 18776908
dgv1892e1 CNV Complex 17122850
dgv1893e1 CNV Complex 17122850
dgv1894e1 CNV Complex 17122850
esv29987 CNV Loss 17803354
dgv1895e1 CNV Complex 17122850
nsv524816 CNV Loss 19592680
dgv6418n71 CNV Gain 21882294
nsv525541 CNV Gain 19592680
dgv991n67 CNV Gain 20364138
nsv883345 CNV Gain 21882294
nsv823390 CNV Gain 20364138
nsv883346 CNV Gain 21882294
esv2421645 CNV Duplication 20811451
essv24628 CNV CNV 17122850
dgv1896e1 CNV Complex 17122850
essv23730 CNV CNV 17122850
nsv5164 CNV Insertion 18451855
nsv883347 CNV Gain 21882294
dgv6419n71 CNV Loss 21882294
dgv6420n71 CNV Gain 21882294
dgv6421n71 CNV Loss 21882294
esv1057238 CNV Insertion 17803354
nsv349805 CNV Loss 16902084
esv995174 CNV Deletion 20482838
nsv883355 CNV Gain+Loss 21882294
nsv883357 CNV Gain+Loss 21882294
nsv437476 CNV Loss 16327808
nsv5166 CNV Insertion 18451855

Variation tolerance for DUSP22 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP22 Gene

HapMap Linkage Disequilibrium report
DUSP22
Human Gene Mutation Database (HGMD)
DUSP22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP22 Gene

Disorders for DUSP22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymphatic system cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP22

Genetic Association Database (GAD)
DUSP22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP22
genes like me logo Genes that share disorders with DUSP22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP22 Gene

Publications for DUSP22 Gene

  1. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. (PMID: 11717427) Shen Y. … Tonks N.K. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 67
  2. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. (PMID: 20018849) Li J.P. … Tan T.H. (J. Biol. Chem. 2010) 3 23
  3. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. (PMID: 17384676) Sekine Y. … Matsuda T. (Oncogene 2007) 3 23
  4. Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). (PMID: 9205128) Smith A. … Ashworth A. (Genomics 1997) 2 3
  5. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. (PMID: 24436131) Sanchez-Mut J.V. … Esteller M. (Hippocampus 2014) 3

Products for DUSP22 Gene

Sources for DUSP22 Gene

Back to Top

Content