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Aliases for DUSP21 Gene

Aliases for DUSP21 Gene

  • Dual Specificity Phosphatase 21 2 3
  • LMWDSP21 3 4 6
  • Low Molecular Weight Dual Specificity Phosphatase 21 3 4
  • LMW-DSP21 3 4
  • Dual Specificity Protein Phosphatase 21 3
  • BJ-HCC-26 Tumor Antigen 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for DUSP21 Gene

Summaries for DUSP21 Gene

Entrez Gene Summary for DUSP21 Gene

  • This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]

GeneCards Summary for DUSP21 Gene

DUSP21 (Dual Specificity Phosphatase 21) is a Protein Coding gene. Diseases associated with DUSP21 include colorectal cancer. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for DUSP21 Gene

  • Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP21 Gene

Genomics for DUSP21 Gene

Genomic Location for DUSP21 Gene

Start:
44,844,003 bp from pter
End:
44,844,888 bp from pter
Size:
886 bases
Orientation:
Plus strand

Genomic View for DUSP21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP21 Gene

Regulatory Elements for DUSP21 Gene

Proteins for DUSP21 Gene

  • Protein details for DUSP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H596-DUS21_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 21
    Protein Accession:
    Q9H596
    Secondary Accessions:
    • Q0VDA6
    • Q6IAJ6
    • Q6YDQ8

    Protein attributes for DUSP21 Gene

    Size:
    190 amino acids
    Molecular mass:
    21529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DUSP21 Gene

Proteomics data for DUSP21 Gene at MOPED

Post-translational modifications for DUSP21 Gene

No Post-translational modifications

Other Protein References for DUSP21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP21 Gene

Domains for DUSP21 Gene

Gene Families for DUSP21 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

UniProtKB/Swiss-Prot:

DUS21_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q9H596
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.:
    • Q9H596
genes like me logo Genes that share domains with DUSP21: view

Function for DUSP21 Gene

Molecular function for DUSP21 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine

Enzyme Numbers (IUBMB) for DUSP21 Gene

Gene Ontology (GO) - Molecular Function for DUSP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 12408986
GO:0005515 protein binding IPI 25416956
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP21: view

Phenotypes for DUSP21 Gene

GenomeRNAi human phenotypes for DUSP21:
genes like me logo Genes that share phenotypes with DUSP21: view

miRNA for DUSP21 Gene

miRTarBase miRNAs that target DUSP21

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP21 Gene

Localization for DUSP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP21 Gene

Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP21 Gene COMPARTMENTS Subcellular localization image for DUSP21 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12408986
GO:0005737 cytoplasm IDA 12408986
GO:0005743 mitochondrial inner membrane --
GO:0005759 mitochondrial matrix IEA --
GO:0031314 extrinsic component of mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with DUSP21: view

Pathways for DUSP21 Gene

SuperPathways for DUSP21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IDA 12408986
genes like me logo Genes that share ontologies with DUSP21: view

No data available for Pathways by source for DUSP21 Gene

Compounds for DUSP21 Gene

(3) HMDB Compounds for DUSP21 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with DUSP21: view

Transcripts for DUSP21 Gene

mRNA/cDNA for DUSP21 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP21 Gene

Dual specificity phosphatase 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP21 Gene

No ASD Table

Relevant External Links for DUSP21 Gene

GeneLoc Exon Structure for
DUSP21
ECgene alternative splicing isoforms for
DUSP21

Expression for DUSP21 Gene

mRNA expression in normal human tissues for DUSP21 Gene

mRNA differential expression in normal tissues according to GTEx for DUSP21 Gene

This gene is overexpressed in Testis (51.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP21 Gene

SOURCE GeneReport for Unigene cluster for DUSP21 Gene Hs.534478

mRNA Expression by UniProt/SwissProt for DUSP21 Gene

Q9H596-DUS21_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with DUSP21: view

Orthologs for DUSP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP21 36
  • 98.94 (n)
  • 98.41 (a)
DUSP21 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DUSP21 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP21 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp21 16
Dusp21 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DUSP18 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15528 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C04F12.8 37
  • 26 (a)
ManyToMany
F13D11.3 37
  • 32 (a)
ManyToMany
F26A3.4 37
  • 31 (a)
ManyToMany
ZK757.2 37
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10229 37
  • 43 (a)
OneToMany
Species with no ortholog for DUSP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DUSP21 Gene

ENSEMBL:
Gene Tree for DUSP21 (if available)
TreeFam:
Gene Tree for DUSP21 (if available)

Paralogs for DUSP21 Gene

Selected SIMAP similar genes for DUSP21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP21: view

Variants for DUSP21 Gene

Sequence variations from dbSNP and Humsavar for DUSP21 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1045031 - 44,844,689(+) ACGTA(C/T)GATGA missense, reference
rs12835200 -- 44,843,247(+) ATTAC(C/T)GGGAA upstream-variant-2KB
rs12859085 -- 44,843,245(+) ATATT(A/T)CTGGG upstream-variant-2KB
rs35028969 -- 44,844,510(+) ACTCC(-/C)ATGTC reference, frameshift-variant
rs35101213 -- 44,844,624(-) ACGGT(A/G)TTGTT reference, synonymous-codon

Relevant External Links for DUSP21 Gene

HapMap Linkage Disequilibrium report
DUSP21
Locus Specific Mutation Databases (LSDB)
DUSP21

No data available for Structural Variations from Database of Genomic Variants (DGV) for DUSP21 Gene

Disorders for DUSP21 Gene

(1) MalaCards Diseases for DUSP21 Gene

Search for DUSP21 Gene in MalaCards »
genes like me logo Genes that share disorders with DUSP21: view

No data available for UniProtKB/Swiss-Prot for DUSP21 Gene

Publications for DUSP21 Gene

  1. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood K.L. … Yoon C. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for DUSP21 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DUSP21
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP21
    • Block miRNA regulation of DUSP21 using miScript Target Protectors

    Sources for DUSP21 Gene

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