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DUSP21 Gene

protein-coding   GIFtS: 50
GCID: GC0XP044703

Dual Specificity Phosphatase 21

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 211 2     BJ-HCC-26 Tumor Antigen2
LMWDSP212 3 5     Dual Specificity Protein Phosphatase 212
Low Molecular Weight Dual Specificity Phosphatase 212 3     EC 3.1.3.163
LMW-DSP212 3     EC 3.1.3.483

External Ids:    HGNC: 204761   Entrez Gene: 639042   Ensembl: ENSG000001890377   OMIM: 3006785   UniProtKB: Q9H5963   

Export aliases for DUSP21 gene to outside databases

Previous GC identifers: GC0XP042963 GC0XP043529 GC0XP043749 GC0XP044459 GC0XP044588 GC0XP042424


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP21 Gene:
This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual
specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions
to remove phosphate groups from phosphotyrosine and phosphothreonine residues.(provided by RefSeq, Mar 2009)

GeneCards Summary for DUSP21 Gene:
DUSP21 (dual specificity phosphatase 21) is a protein-coding gene. Diseases associated with DUSP21 include breast and colorectal cancer, and colorectal cancer. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596
Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the
phosphotyrosine and diphosphorylated forms over phosphothreonine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP21 gene promoter:
         AP-1   Pax-5   CUTL1   NF-E2 p45   POU2F1   POU2F1a   POU2F1b   POU2F1c   NF-E2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP21 promoter sequence
   Search Chromatin IP Primers for DUSP21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4-p11.23   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.4-p11.23

DUSP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP21 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP044703:  view genomic region     (about GC identifiers)

Start:
44,703,249 bp from pter      End:
44,704,134 bp from pter
Size:
886 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 21  
Size: 190 amino acids; 21529 Da
Secondary accessions: Q0VDA6 Q6IAJ6 Q6YDQ8

Explore the universe of human proteins at neXtProt for DUSP21: NX_Q9H596

Explore proteomics data for DUSP21 at MOPED


See DUSP21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_071359.3  
ENSEMBL proteins: 
 ENSP00000343244  

DUSP21 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Selected InterPro protein domains (see all 7):
 IPR000387 Tyr/Dual-sp_Pase
 IPR020422 Dual-sp_phosphatase_subgr_cat
 IPR016130 Tyr_Pase_AS
 IPR020417 Atypical_DUSP
 IPR024950 DUSP

Graphical View of Domain Structure for InterPro Entry Q9H596

ProtoNet protein and cluster: Q9H596

1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain


DUSP21 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DUS21_HUMAN, Q9H596
Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the
phosphotyrosine and diphosphorylated forms over phosphothreonine
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

     Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004725protein tyrosine phosphatase activity IDA12408986
GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
GO:0016791phosphatase activity ----
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IEA--
     
DUSP21 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for DUSP21:
 Increased HPV18 LCR reporter a 

Animal Models:
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miRNA
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miRTarBase miRNAs that target DUSP21:
hsa-mir-26b-5p (MIRT029371)

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SwitchGear 3'UTR luciferase reporter plasmidDUSP21 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DUS21_HUMAN, Q9H596: Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
(By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
nucleus5
cytosol3
peroxisome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA12408986
GO:0005737cytoplasm IDA12408986
GO:0005743mitochondrial inner membrane ----
GO:0031305integral component of mitochondrial inner membrane IEA--

DUSP21 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUSP21
Interactions:

    Search GeneGlobe Interaction Network for DUSP21

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for DUSP21 (Q9H5962, 3 ENSP000003432444) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RGS2P412202, 3, ENSP000002353824MINT-8268746 I2D: score=2 STRING: ENSP00000235382
About this table

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006470protein dephosphorylation ----
GO:0016311dephosphorylation ----
GO:0035335peptidyl-tyrosine dephosphorylation IDA12408986

DUSP21 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DUSP21 (DUS21)

3 HMDB Compounds for DUSP21    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
PhosphateNFB Orthophosphate (see all 13)14265-44-2--
WaterDihydrogen oxide (see all 2)7732-18-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DUSP21 gene: 
NM_022076.3  

Unigene Cluster for DUSP21:

Dual specificity phosphatase 21
Hs.534478  [show with all ESTs]
Unigene Representative Sequence: AY156515
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000339042(uc004dgd.3)
miRNA
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Primer
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  QuantiTect SYBR Green Assays in human, mouse, rat DUSP21
  QuantiFast Probe-based Assays in human, mouse, rat DUSP21

Additional mRNA sequence: 

AF143321.1 AF533018.1 AY121807.1 AY156515.1 BC119755.1 BC119756.1 CR457159.1 

1 DOTS entry:

DT.409455 

14 AceView cDNA sequences:

BX090578 NM_022076 CR457159 AY156515 AI025489 AA725688 AY121807 BV201224 
AF533018 AF143321 AA813372 T88897 AA813123 AW514251 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DUSP21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAACATAAAA
DUSP21 Expression
About this image

DUSP21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DUSP21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.534478

UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596
Tissue specificity: Expressed in testis

    Custom PCR Arrays for DUSP21
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DUSP21 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dusp215 dual specificity phosphatase 21   --   X (13.44 cM) 18145857 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
45(a)
1 → many
15(10775401-10776498)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
58(a)
1 → many
GL343417.1(197291-197857)
zebrafish
(Danio rerio)
Actinopterygii DUSP186
dual specificity phosphatase 18
45(a)
1 → many
5(72402198-72404174) ENSDARG00000067564
fruit fly
(Drosophila melanogaster)
Insecta CG155286
--
31(a)
1 → many
3R(25874357-25877834)
worm
(Caenorhabditis elegans)
Secernentea F13D11.36
F26A3.46
(see all 4)
Protein F26A3.4 (F26A3.4) mRNA, complete cds
(see all 4)
32(a)
31(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
X(5804387-5805922) WBGene00017428
I(7656907-7658291) WBGene00009142


ENSEMBL Gene Tree for DUSP21 (if available)
TreeFam Gene Tree for DUSP21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DUSP21 gene
DUSP262  DUPD12  DUSP32  DUSP132  DUSP272  STYX2  DUSP142  DUSP192  
DUSP282  DUSP152  DUSP222  DUSP182  
9 SIMAP similar genes for DUSP21 using alignment to 1 protein entry:     DUS21_HUMAN:
DUSP18    DUSP14    DUSP8    DUSP16    DUSP19    DUSP13
DUSP10    DUSP7    DUSP15

DUSP21 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DUSP21 (see all 73)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0356444
A colorectal cancer sample4--see VAR_0356442 R C mis40--------
rs1832416311,2
C--44619923(+) GTGGCA/GCGAGC 1 -- us2k10--------
rs1871609411,2
C--44620010(+) GATCGC/TGCCAC 1 -- us2k10--------
rs1911565101,2
--44620027(+) CCAGCC/TTGGGC 1 -- us2k10--------
rs1826603121,2
--44620109(+) TTTGTC/TAATTG 1 -- us2k10--------
rs1865871241,2
--44620216(+) TCTCCA/GTTAGC 1 -- us2k10--------
rs1438985251,2
C--44620270(+) TATTCA/GTGTTC 1 -- us2k10--------
rs1472461991,2
C--44620323(+) AATGCA/GAAATA 1 -- us2k10--------
rs1482882591,2
--44620367(+) GTTGTA/GTTTTG 1 -- us2k10--------
rs1414082521,2
--44620373(+) TTTTGA/TGGTTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for DUSP21 (44703249 - 44704134 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DUSP21: --
Human Gene Mutation Database (HGMD): DUSP21
Locus Specific Mutation Databases (LSDB): DUSP21

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DUSP21
DNA2.0 Custom Variant and Variant Library Synthesis for DUSP21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300678    OMIM disorders: --

2 diseases for DUSP21:    
About MalaCards
breast and colorectal cancer    colorectal cancer


DUSP21 for disorders           About GeneDecksing


Export disorders for DUSP21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DUSP21 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DUSP21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PubMed id 12408986)1, 2, 3 Hood K.L.... Yoon C. (Biochem. Biophys. Res. Commun. 2002)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  5. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
  6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 63904 HGNC: 20476 AceView: DUSP21 Ensembl:ENSG00000189037 euGenes: HUgn63904
ECgene: DUSP21 H-InvDB: DUSP21

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DUSP21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DUSP21 gene:
Search GeneIP for patents involving DUSP21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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