DUSP21 Gene
protein-coding GIFtS: 49
GCID: GC0XP044703
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|
dual specificity phosphatase 21
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Aliases
for DUSP21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dual Specificity Phosphatase 211 2 | | BJ-HCC-26 Tumor Antigen2 | | Low Molecular Weight Dual Specificity Phosphatase 212 3 | | Dual Specificity Protein Phosphatase 212 | | LMW-DSP212 3 | | EC 3.1.3.163 | | LMWDSP212 3 | | EC 3.1.3.483 |
Export aliases for DUSP21 gene to outside databasesPrevious GC identifers: GC0XP042963 GC0XP043529 GC0XP043749 GC0XP044459 GC0XP044588 GC0XP042424 |
Summaries
for DUSP21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DUSP21:
This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dualspecificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions toremove phosphate groups from phosphotyrosine and phosphothreonine residues.(provided by RefSeq, Mar 2009)
UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for thephosphotyrosine and diphosphorylated forms over phosphothreonine
|
Genomic Views
for DUSP21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DUSP21 gene promoter:
AP-1 Pax-5 CUTL1 NF-E2 p45 POU2F1 POU2F1a POU2F1b POU2F1c NF-E2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DUSP21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.4-p11.23 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.4-p11.23DUSP21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP044703: view genomic region
(about GC identifiers)
Start:
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44,703,249 bp from pter |
End:
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44,704,134 bp from pter |
Size:
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886 bases |
Orientation:
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plus strand |
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Proteins
for DUSP21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596 (See
protein sequence)Recommended Name: Dual specificity protein phosphatase 21 Size: 190 amino acids; 21529 Da
Subcellular location: Cytoplasm. Nucleus. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (Bysimilarity)
Secondary accessions: Q0VDA6 Q6IAJ6 Q6YDQ8Explore the universe of human proteins at neXtProt for DUSP21: NX_Q9H596
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H596
DUSP21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071359.3
ENSEMBL proteins: ENSP00000343244
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DUSP21 for ontologies About GeneDecksing
DUSP21 Antibody Products:
Assay Products for DUSP21: |
Protein
Domains /
Families
for DUSP21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DUSP21 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9H596ProtoNet protein and cluster: Q9H596 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamilySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for DUSP21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for thephosphotyrosine and diphosphorylated forms over phosphothreonineCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP21
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP21 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004725 | protein tyrosine phosphatase activity |
IDA | 12408986 | | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
IBA | -- | | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity |
IEA | -- |
DUSP21 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DUSP21:
|
Pathways & Interactions
for DUSP21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DUSP21
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for DUSP21 (Q9H5962, 3 ENSP000003432444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035335 | peptidyl-tyrosine dephosphorylation |
IDA | 12408986 |
DUSP21 for ontologies About GeneDecksing
|
Drugs & Compounds
for DUSP21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DUSP21
3 HMDB Compounds for DUSP21 About this table
Search CenterWatch for drugs/clinical trials and news about DUSP21 / DUS21
|
Transcripts
for DUSP21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DUSP21 gene: NM_022076.3 Unigene Cluster for DUSP21: Dual specificity phosphatase 21 Hs.534478 [show with all ESTs]Unigene Representative Sequence: AY1565151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000339042(uc004dgd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP21 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP21
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DUSP21 (NM_022076) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DUSP21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP21 |
Additional cDNA sequence: AF143321.1 AF533018.1 AY121807.1 AY156515.1 BC119755.1 BC119756.1 CR457159.1 1 DOTS entry: DT.409455 14 AceView cDNA sequences: BX090578 AF143321 AY121807 BV201224 AI025489 AA725688 AY156515 CR457159 NM_022076 AF533018 AA813372 T88897 AA813123 AW514251
GeneLoc Exon Structure
|
Expression
for DUSP21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DUSP21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACATAAAA
About this image
See DUSP21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP21
SOURCE GeneReport for Unigene cluster: Hs.534478
UniProtKB/Swiss-Prot: DUS21_HUMAN, Q9H596Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for DUSP21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DUSP21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP21 |
Orthologs
for DUSP21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DUSP21 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for DUSP21 (if available)
TreeFam Gene Tree for DUSP21 (if available) |
Paralogs
for DUSP21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DUSP21 gene
- DUSP42 SSH22 DUSP102 DUSP62 DUSP192 DUSP142 DUSP282 DUSP82
- DUSP72 DUSP52 SSH32 DUSP162 DUSP92 DUSP22 DUSP182 SSH12
- DUSP12
10 SIMAP similar genes for DUSP21 using alignment to 1 protein entry: DUS21_HUMAN:DUSP18 DUSP14 DUSP8 DUSP16 DUSP19 DUSP13
DUSP10 DUSP7 DUSP15 DUSP28
DUSP21 for paralogs About GeneDecksing
|
Genomic Variants
for DUSP21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DUSP21 (44703249 - 44704134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DUSP21: --
Locus Specific Mutation Databases (LSDB): DUSP21
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP21 |
|
Disorders
/ Diseases
for DUSP21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DUSP21 for disorders About MalaCards
DUSP21 for disorders About GeneDecksing
OMIM gene information: 300678
OMIM disorders: --
Export disorders for DUSP21 gene to outside databases
|
Publications
for DUSP21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DUSP21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUSP21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PubMed id 12408986)1, 2, 3 Hood K.L.... Yoon C. (2002)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DUSP21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DUSP21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DUSP21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DUSP21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DUSP21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DUSP21 gene:
Search GeneIP for patents involving DUSP21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DUSP21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | DUSP21 Proteins, Antibodies, CLIAs, and ELISAs |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP21 |
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