Aliases for DUSP2 Gene
External Ids for DUSP2 Gene
Previous GeneCards Identifiers for DUSP2 Gene
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
GeneCards Summary for DUSP2 Gene
DUSP2 (Dual Specificity Phosphatase 2) is a Protein Coding gene. Diseases associated with DUSP2 include Large Granular Lymphocyte Leukemia. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.
UniProtKB/Swiss-Prot for DUSP2 Gene
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.