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DUSP2 Gene

protein-coding   GIFtS: 60
GCID: GC02M096808

Dual Specificity Phosphatase 2

  See DUSP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 21 2     Dual-Specificity Phosphatase 22
PAC12 3 5     Serine/Threonine Specific Protein Phosphatase2
Dual Specificity Protein Phosphatase PAC-12 3     EC 3.1.3.163
PAC-12     EC 3.1.3.483
Dual Specificity Protein Phosphatase 22     

External Ids:    HGNC: 30681   Entrez Gene: 18442   Ensembl: ENSG000001580507   OMIM: 6030685   UniProtKB: Q059233   

Export aliases for DUSP2 gene to outside databases

Previous GC identifers: GC02M094680 GC02M095263 GC02M096276 GC02M096293 GC02M096230 GC02M096173 GC02M090770


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP2 Gene:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and
phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase
superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.
Different members of the family of dual specificity phosphatases show distinct substrate specificities for
various MAP kinases, different tissue distribution and subcellular localization, and different modes of
inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is
predominantly expressed in hematopoietic tissues, and is localized in the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for DUSP2 Gene:
DUSP2 (dual specificity phosphatase 2) is a protein-coding gene. Diseases associated with DUSP2 include type 2 diabetes mellitus. GO annotations related to this gene include mitogen-activated protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases
ERK1 and ERK2

Gene Wiki entry for DUSP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP2 gene promoter:
         HEN1   p53   AP-1   ATF-2   HNF-4alpha2   c-Jun   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DUSP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11

DUSP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M096808:  view genomic region     (about GC identifiers)

Start:
96,808,905 bp from pter      End:
96,811,179 bp from pter
Size:
2,275 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 2  
Size: 314 amino acids; 34400 Da
1 PDB 3D structure from and Proteopedia for DUSP2:
1M3G (3D)    
Secondary accessions: Q53T45

Explore the universe of human proteins at neXtProt for DUSP2: NX_Q05923

Explore proteomics data for DUSP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157, Lys288
  • Modification sites at PhosphoSitePlus

  • See DUSP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004409.1  
    ENSEMBL proteins: 
     ENSP00000288943  

    DUSP2 Human Recombinant Protein Products:

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    antibodies-online peptides for DUSP2

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    antibodies-online kits for DUSP2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPT: Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

    Selected InterPro protein domains (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q05923

    ProtoNet protein and cluster: Q05923

    2 Blocks protein domains:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with DUSP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS2_HUMAN, Q05923
    Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases
    ERK1 and ERK2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Induction: By mitogens

         Genatlas biochemistry entry for DUSP2:
    dual specificity (tyr/thr) phosphatase 2,expressed in hematopoietic tissues,involved in signal transduction

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
    GO:0008330protein tyrosine/threonine phosphatase activity TAS8107850
         
    Find genes that share ontologies with DUSP2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DUSP2:
     Increased cell death in HCC-19  Increased focal adhesion (FA)   Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dusp2):
     hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with DUSP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dusp2tm1Cmac for DUSP2

       genOway: Develop your customized and physiologically relevant rodent model for DUSP2

    miRNA
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    miRTarBase miRNAs that target DUSP2:
    hsa-mir-29b-3p (MIRT007102), hsa-mir-122-5p (MIRT003094), hsa-mir-124-3p (MIRT023093)

    Block miRNA regulation of human, mouse, rat DUSP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DUSP2 (see all 31):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-3194-5p hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-302e
    SwitchGear 3'UTR luciferase reporter plasmidDUSP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DUSP2

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DUS2_HUMAN, Q05923: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8107850
    GO:0005654nucleoplasm IBA--

    Find genes that share ontologies with DUSP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DUSP2 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50


    Find genes that share SuperPaths with DUSP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for DUSP2):
        MAPK signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUSP2
    Interactions:

        GeneGlobe Interaction Network for DUSP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DUSP2 (Q059232, 3 ENSP000002889434) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8217415 I2D: score=2 STRING: ENSP00000215832
    MAPK3P273612, 3, ENSP000002630254MINT-8288639 I2D: score=1 STRING: ENSP00000263025
    MAPK14Q165393, ENSP000002297944I2D: score=2 STRING: ENSP00000229794
    MAPK10ENSP000003521574STRING: ENSP00000352157
    MAPK11ENSP000003336854STRING: ENSP00000333685
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0001706endoderm formation IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7681221

    Find genes that share ontologies with DUSP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP2 (DUS2)

    3 HMDB Compounds for DUSP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for DUSP2 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 86.5 8 9013447 (5), 7961985 (1), 9178761 (1), 7535768 (1)
    mdmp 85.8 1 15668187 (1)
    pdmp 81.7 3 15203718 (1), 14679788 (1), 15668187 (1)
    bisindolylmaleimide 52.4 1 7537313 (1)
    fibrinogen 51.2 11 10582178 (2), 17000890 (1), 12386643 (1), 15203716 (1) (see all 8)
    adenylate 47.9 3 12409223 (2), 15993038 (1)
    rantes 39.1 3 15829999 (1), 15668187 (1), 12361207 (1)
    adp 34.5 5 17000890 (2), 18217151 (1), 16268475 (1)
    phosphotyrosine 29.6 1 7681221 (1)
    dipyridamole 28.7 1 10582178 (1)



    Find genes that share compounds with DUSP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DUSP2 gene: 
    NM_004418.3  

    Unigene Cluster for DUSP2:

    Dual specificity phosphatase 2
    Hs.1183  [show with all ESTs]
    Unigene Representative Sequence: L11329
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288943(uc002svk.4) ENST00000488952
    miRNA
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    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-3194-5p hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-302e
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    Additional mRNA sequence: 

    BC007771.2 L11329.1 

    7 DOTS entries:

    DT.100748370  DT.312281  DT.97841497  DT.95270646  DT.120931860  DT.91745584  DT.95270643 

    Selected AceView cDNA sequences (see all 88):

    AW294543 BF478007 BI767129 AI393848 BQ941948 BG057719 T28368 BC007771 
    CR609480 AA284105 BQ271664 CR614078 BU171394 AI675467 BG679344 AI359539 
    CR613393 AI634408 BQ286359 AA356558 BI907344 AI972455 AA641809 BM562365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCGTGTGT
    DUSP2 Expression
    About this image


    DUSP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced E15 cells
    DUSP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1183

    UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
    Tissue specificity: Expressed in hematopoietic tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DUSP2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp21 , 5 dual specificity phosphatase 21, 5 85.24(n)1
    87.58(a)1
      2 (61.93 cM)5
    135371  NM_010090.21  NP_034220.21 
     1273361595 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP26
    dual specificity phosphatase 2
    73(a)
    1 ↔ 1
    AAWZ02039278(3748-8962)
    zebrafish
    (Danio rerio)
    Actinopterygii dusp21 dual specificity phosphatase 2 59.06(n)
    54.66(a)
      445057  NM_001003451.1  NP_001003451.1 


    ENSEMBL Gene Tree for DUSP2 (if available)
    TreeFam Gene Tree for DUSP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP2 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP92  
    DUSP82  DUSP12  DUSP72  SSH12  
    8 SIMAP similar genes for DUSP2 using alignment to 1 protein entry:     DUS2_HUMAN:
    DUSP1    DUSP4    DUSP5    DUSP10    DUSP6    DUSP16
    DUSP7    DUSP8

    Find genes that share paralogs with DUSP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP2 (see all 120)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829160621,2
    --96808422(+) TGGGAA/GAAGAG 1 -- ds50010--------
    rs606262941,2
    C,F--96808509(+) ACACAC/TGCTCC 1 -- ds50011Minor allele frequency- T:0.17EA 120
    rs17241211,2
    C,F,A,H--96808549(-) GGCCCG/ATGCAC 1 -- ds50019Minor allele frequency- A:0.48EA NA WA CSA 1850
    rs1393183141,2
    --96808574(+) CCACAC/GGACCA 1 -- ds50010--------
    rs750597881,2
    F--96808584(+) ACACCC/TTCAGG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1883637031,2
    --96808599(+) CACTCA/GCATCC 1 -- ds50010--------
    rs1179762121,2
    F--96808667(+) AGTCAC/TGGACG 1 -- ds50011Minor allele frequency- T:0.06EA 120
    rs1141136161,2
    C,F--96808673(+) GGACGG/TGACCC 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1175484561,2
    F--96808756(+) AACTGG/CGGCCA 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs747204101,2
    F--96808768(+) GAGAGC/TAGCCT 1 -- ds50011Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for DUSP2 (96808905 - 96811179 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DUSP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv650e201CNV Deletion23290073
    dgv4247n71CNV Loss21882294
    dgv4248n71CNV Loss21882294
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603068    OMIM disorders: --

    1 disease for DUSP2:    
    About MalaCards
    type 2 diabetes mellitus


    Find genes that share disorders with DUSP2           About GenesLikeMe

    4 Novoseek inferred disease relationships for DUSP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 31.1 1 16093733 (1)
    thrombosis 5.63 2 9814673 (1), 19741191 (1)
    shock 0 4 7681221 (1), 7585624 (1)
    tumors 0 2 12409223 (2)

    Genetic Association Database (GAD): DUSP2
    Human Genome Epidemiology (HuGE) Navigator: DUSP2 (4 documents)

    Export disorders for DUSP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP2 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with DUSP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. (PubMed id 7590752)1, 2, 3, 9 Yi H.... Kelly K. (Genomics 1995)
    2. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. (PubMed id 12673251)1, 3, 9 Yin Y....Barrett J.C. (Nature 2003)
    3. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. (PubMed id 7681221)1, 2, 9 Rohan P.... Kelly K. (Science 1993)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (PubMed id 17827388)1, 4 Cerhan J.R....Slager S.L. (Blood 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. (PubMed id 12575935)1, 2 Farooq A....Zhou M.M. (Structure 2003)
    8. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PubMed id 7806236)1, 3 Martell K.J....Trent J.M. (Genomics 1994)
    9. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. (PubMed id 17471234)1, 9 Wu J....Yin Y. (Oncogene 2007)
    10. New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. (PubMed id 16288922)1, 9 Zhang Q....Zhou M.M. (J. Mol. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1844 HGNC: 3068 AceView: DUSP2 Ensembl:ENSG00000158050 euGenes: HUgn1844
    ECgene: DUSP2 Kegg: 1844 H-InvDB: DUSP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DUSP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DUSP2 gene:
    Search GeneIP for patents involving DUSP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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