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Aliases for DUSP2 Gene

Aliases for DUSP2 Gene

  • Dual Specificity Phosphatase 2 2 3 5
  • Dual Specificity Protein Phosphatase PAC-1 3 4
  • PAC1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual-Specificity Phosphatase 2 3
  • EC 4
  • EC 4
  • PAC-1 3

External Ids for DUSP2 Gene

Previous GeneCards Identifiers for DUSP2 Gene

  • GC02M094680
  • GC02M095263
  • GC02M096276
  • GC02M096293
  • GC02M096230
  • GC02M096173
  • GC02M096808
  • GC02M090770
  • GC02M096147
  • GC02M096148

Summaries for DUSP2 Gene

Entrez Gene Summary for DUSP2 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP2 Gene

DUSP2 (Dual Specificity Phosphatase 2) is a Protein Coding gene. Diseases associated with DUSP2 include Large Granular Lymphocyte Leukemia. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP2 Gene

  • Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Gene Wiki entry for DUSP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP2 Gene

Genomics for DUSP2 Gene

Regulatory Elements for DUSP2 Gene

Enhancers for DUSP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUSP2 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DUSP2 Gene

96,143,166 bp from pter
96,145,440 bp from pter
2,275 bases
Minus strand

Genomic View for DUSP2 Gene

Genes around DUSP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP2 Gene

Proteins for DUSP2 Gene

  • Protein details for DUSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 2
    Protein Accession:
    Secondary Accessions:
    • Q53T45

    Protein attributes for DUSP2 Gene

    314 amino acids
    Molecular mass:
    34400 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP2 Gene

neXtProt entry for DUSP2 Gene

Proteomics data for DUSP2 Gene at MOPED

Post-translational modifications for DUSP2 Gene

  • Ubiquitination at Lys 157 and Lys 288
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP2 Gene

Domains & Families for DUSP2 Gene

Gene Families for DUSP2 Gene

Suggested Antigen Peptide Sequences for DUSP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP2: view

Function for DUSP2 Gene

Molecular function for DUSP2 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 2,expressed in hematopoietic tissues,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
UniProtKB/Swiss-Prot Induction:
By mitogens.

Enzyme Numbers (IUBMB) for DUSP2 Gene

Gene Ontology (GO) - Molecular Function for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IEA,IPI 21784977
GO:0008330 protein tyrosine/threonine phosphatase activity TAS 8107850
GO:0016791 phosphatase activity IEA --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP2: view
genes like me logo Genes that share phenotypes with DUSP2: view

Animal Models for DUSP2 Gene

MGI Knock Outs for DUSP2:

Animal Model Products

miRNA for DUSP2 Gene

miRTarBase miRNAs that target DUSP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DUSP2 Gene

Localization for DUSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP2 Gene

Subcellular locations from

Jensen Localization Image for DUSP2 Gene COMPARTMENTS Subcellular localization image for DUSP2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DUSP2 Gene

Pathways & Interactions for DUSP2 Gene

SuperPathways for DUSP2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by GPCR
5 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP2: view

Pathways by source for DUSP2 Gene

SIGNOR curated interactions for DUSP2 Gene


Gene Ontology (GO) - Biological Process for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001706 endoderm formation IBA --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7681221
genes like me logo Genes that share ontologies with DUSP2: view

Drugs & Compounds for DUSP2 Gene

(5) Drugs for DUSP2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(13) Additional Compounds for DUSP2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DUSP2: view

Transcripts for DUSP2 Gene

mRNA/cDNA for DUSP2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(88) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP2 Gene

Dual specificity phosphatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP2 Gene

No ASD Table

Relevant External Links for DUSP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP2 Gene

mRNA expression in normal human tissues for DUSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP2 Gene

This gene is overexpressed in Whole Blood (x9.5).

Protein differential expression in normal tissues from HIPED for DUSP2 Gene

This gene is overexpressed in Breast (43.3) and Platelet (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DUSP2 Gene

SOURCE GeneReport for Unigene cluster for DUSP2 Gene Hs.1183

mRNA Expression by UniProt/SwissProt for DUSP2 Gene

Tissue specificity: Expressed in hematopoietic tissues.
genes like me logo Genes that share expression patterns with DUSP2: view

Protein tissue co-expression partners for DUSP2 Gene

Primer Products

Orthologs for DUSP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP2 35
  • 88.32 (n)
  • 90.13 (a)
DUSP2 36
  • 90 (a)
(Canis familiaris)
Mammalia DUSP2 35
  • 89.07 (n)
  • 89.03 (a)
DUSP2 36
  • 88 (a)
(Mus musculus)
Mammalia Dusp2 35
  • 85.24 (n)
  • 87.58 (a)
Dusp2 16
Dusp2 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Dusp2 35
  • 84.82 (n)
  • 88.54 (a)
(Monodelphis domestica)
Mammalia DUSP2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia DUSP2 36
  • 73 (a)
(Danio rerio)
Actinopterygii dusp2 35
  • 59.06 (n)
  • 54.66 (a)
dusp2 36
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for DUSP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP2 Gene

Gene Tree for DUSP2 (if available)
Gene Tree for DUSP2 (if available)

Paralogs for DUSP2 Gene

Paralogs for DUSP2 Gene

(8) SIMAP similar genes for DUSP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP2: view

Variants for DUSP2 Gene

Sequence variations from dbSNP and Humsavar for DUSP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2969489 -- 96,145,695(-) GTGCT(A/G)GTCCC upstream-variant-2KB
rs3813659 -- 96,147,080(-) CCAAG(G/T)TGCCC upstream-variant-2KB
rs3813660 -- 96,146,482(-) AGGGC(A/G)GAATG upstream-variant-2KB
rs34212121 -- 96,147,238(+) AGGGG(-/G)CAAAT upstream-variant-2KB
rs74544203 -- 96,147,096(+) GCCCC(A/G)CTGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP2 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
dgv4247n71 CNV Loss 21882294
dgv4248n71 CNV Loss 21882294
nsv874677 CNV Loss 21882294

Variation tolerance for DUSP2 Gene

Gene Damage Index Score: 1.25; 24.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DUSP2 Gene

Disorders for DUSP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DUSP2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
large granular lymphocyte leukemia
  • t-cell large granular lymphocyte leukemia
- elite association - COSMIC cancer census association via MalaCards
Search DUSP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DUSP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DUSP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP2 Gene

Publications for DUSP2 Gene

  1. Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. (PMID: 7590752) Yi H. … Kelly K. (Genomics 1995) 2 3 4 23 67
  2. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. (PMID: 12673251) Yin Y. … Barrett J.C. (Nature 2003) 2 3 23
  3. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. (PMID: 17471234) Wu J. … Yin Y. (Oncogene 2007) 3 23
  4. New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. (PMID: 16288922) Zhang Q. … Zhou M.M. (J. Mol. Biol. 2005) 3 23
  5. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PMID: 7806236) Martell K.J. … Trent J.M. (Genomics 1994) 2 3

Products for DUSP2 Gene

Sources for DUSP2 Gene