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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DUSP2 Gene

protein-coding   GIFtS: 60
GCID: GC02M096808

dual specificity phosphatase 2
 Explore 30 diseases affiliated with
DUSP2 via
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Biological research products
for DUSP2    

Aliases
for DUSP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dual Specificity Phosphatase 21 2     Dual-Specificity Phosphatase 22
PAC12 3 5     Serine/Threonine Specific Protein Phosphatase2
PAC-11 2     EC 3.1.3.163
Dual Specificity Protein Phosphatase PAC-12 3     EC 3.1.3.483
Dual Specificity Protein Phosphatase 22     

External Ids:    HGNC: 30681   Entrez Gene: 18442   Ensembl: ENSG000001580507   OMIM: 6030685   UniProtKB: Q059233   

Export aliases for DUSP2 gene to outside databases

Previous GC identifers: GC02M094680 GC02M095263 GC02M096276 GC02M096293 GC02M096230 GC02M096173 GC02M090770


Summaries
for DUSP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DUSP2:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases
inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.
They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38),
which are associated with cellular proliferation and differentiation. Different members of the family of dual
specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution
and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This
gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the
nucleus. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1
and ERK2

Gene Wiki entry for DUSP2


Genomic Views
for DUSP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DUSP2 gene promoter:
         HEN1   p53   AP-1   ATF-2   HNF-4alpha2   c-Jun   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DUSP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11

DUSP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M096808:  view genomic region     (about GC identifiers)

Start:
 96,808,905 bp from pter      End:
 96,811,179 bp from pter
Size:
 2,275 bases      Orientation:
 minus strand

Proteins
for DUSP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 2  
Size: 314 amino acids; 34400 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for DUSP2:
1M3G (3D)    
Secondary accessions: Q53T45

Explore the universe of human proteins at neXtProt for DUSP2: NX_Q05923

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05923

    • DUSP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004409.1  
    ENSEMBL proteins: 
     ENSP00000288943  

    Human Recombinant Protein Products: 
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    Uscn Proteins for DUSP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8107850
    GO:0005654nucleoplasm IBA--


    DUSP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DUSP2

    Protein Domains /
    Families
    for DUSP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DUSP2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001763 Rhodanese-like_dom
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q05923

    ProtoNet protein and cluster: Q05923

    2 Blocks protein families:
    IPB000340 Dual specificity protein phosphatase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 rhodanese domain
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Function
    for DUSP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
    Function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1
    and ERK2
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Induction: By mitogens

         Genatlas biochemistry entry for DUSP2:
    dual specificity (tyr/thr) phosphatase 2,expressed in hematopoietic tissues,involved in signal transduction

    Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

    miRNA
    Products:            		miRTarBase miRNAs that target DUSP2:
    hsa-mir-122 (MIRT003094)

    OriGene 3'-UTR Clone: DUSP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP2 (see all 31):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-3194-5p hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-302e
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP2 (see all 7)
    OriGene shRNA RFP: DUSP2
    OriGene siRNA: DUSP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DUSP2

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for DUSP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008330protein tyrosine/threonine phosphatase activity TAS8107850
    GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IBA--


    DUSP2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for DUSP2:
     Increased cell death in HCC-19  Increased focal adhesion (FA)   Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Dusp2tm1Cmac for DUSP2
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dusp2):
     immune system  skeleton 

    DUSP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DUSP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MAPK signaling pathway
    		MAPK signaling pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for DUSP2):
        MAPK signaling pathway


    DUSP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DUSP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for DUSP2 (Q059232, 3 ENSP000002889434) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284822, 3, ENSP000002158324MINT-8217415 I2D: score=2 STRING: ENSP00000215832
    MAPK3P273612, 3, ENSP000002630254MINT-8288639 I2D: score=1 STRING: ENSP00000263025
    MAPK14Q165393, ENSP000002297944I2D: score=2 STRING: ENSP00000229794
    MAPK10ENSP000003521574STRING: ENSP00000352157
    MAPK11ENSP000003336854STRING: ENSP00000333685
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IBA--
    GO:0001706endoderm formation IBA--
    GO:0006470protein dephosphorylation IBA--
    GO:0035335peptidyl-tyrosine dephosphorylation TAS7681221
    GO:0042981regulation of apoptotic process IBA--


    DUSP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DUSP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DUSP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DUSP2

    3 HMDB Compounds for DUSP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    10/14 Novoseek chemical compound relationships for DUSP2 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 100 86.5 8 9013447 (5), 7961985 (1), 9178761 (1), 7535768 (1)
    mdmp 85.8 1 15668187 (1)
    pdmp 81.7 3 15203718 (1), 14679788 (1), 15668187 (1)
    bisindolylmaleimide 52.4 1 7537313 (1)
    fibrinogen 51.2 11 10582178 (2), 17000890 (1), 12386643 (1), 15203716 (1) (see all 8)
    adenylate 47.9 3 12409223 (2), 15993038 (1)
    rantes 39.1 3 15829999 (1), 15668187 (1), 12361207 (1)
    adp 34.5 5 17000890 (2), 18217151 (1), 16268475 (1)
    phosphotyrosine 29.6 1 7681221 (1)
    dipyridamole 28.7 1 10582178 (1)

    Search CenterWatch for drugs/clinical trials and news about DUSP2 / DUS2 

    Transcripts
    for DUSP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DUSP2 gene: 
    NM_004418.3  

    Unigene Cluster for DUSP2:

    Dual specificity phosphatase 2
    Hs.1183  [show with all ESTs]
    Unigene Representative Sequence: L11329
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288943(uc002svk.4) ENST00000488952

    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP2 (see all 31):
    hsa-miR-142-5p hsa-miR-520e hsa-miR-302d hsa-miR-3194-5p hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-302e
    SwitchGear 3'UTR luciferase reporter plasmid: DUSP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP2 (see all 7)
    OriGene shRNA RFP: DUSP2
    OriGene siRNA: DUSP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP2
    Clone
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    Primer
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    Additional cDNA sequence: 

    BC007771.2 L11329.1 

    7 DOTS entries:

    DT.100748370  DT.312281  DT.97841497  DT.95270646  DT.120931860  DT.91745584  DT.95270643 

    24/88 AceView cDNA sequences (see all 88):

    BG679344 BU171394 T28368 CR613393 AW294543 BC007771 AA356558 BQ941948 
    AI675467 CR609480 BG057719 AI359539 BI767129 BQ271664 CR614078 AI634408 
    BF478007 BQ286359 AI393848 AA284105 BP338975 BI907344 AL555885 AV724284 

    GeneLoc Exon Structure


    Expression
    for DUSP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DUSP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCGTGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DUSP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DUSP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DUSP2

    SOURCE GeneReport for Unigene cluster: Hs.1183

    UniProtKB/Swiss-Prot: DUS2_HUMAN, Q05923
    Tissue specificity: Expressed in hematopoietic tissues

        SABiosciences Custom PCR Arrays for DUSP2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP2

    Orthologs
    for DUSP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP2 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DUSP26
    		 --
    		 72(a)
    		 1 ↔ 1
    		 AAWZ02039278(3748-6691)
    zebrafish
    (Danio rerio)    		 Actinopterygii dusp21 dual specificity phosphatase 2 58.01(n)
    53.85(a)    		   445057  NM_001003451.1  NP_001003451.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DSPTP1E6
    		 protein-tyrosine-phosphatase IBR5
    		 22(a)
    		 possible ortholog
    		 2(1588360-1590166)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 dual specificity protein phosphatase, putative, ex...
    dual specificity protein phosphatase, putative, ex...
    		 19(a)
    18(a)
    		 possible ortholog
    possible ortholog
    		 2(29876197-29879380)
    6(11683181-11686916)


    ENSEMBL Gene Tree for DUSP2 (if available)
    TreeFam Gene Tree for DUSP2 (if available) 

    Paralogs
    for DUSP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DUSP2 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP62  DUSP192  DUSP142  DUSP282  
    DUSP82  DUSP72  DUSP52  SSH32  DUSP162  DUSP92  DUSP182  SSH12  
    DUSP12  
    9 SIMAP similar genes for DUSP2 using alignment to 1 protein entry:     DUS2_HUMAN:
    DUSP1    DUSP4    DUSP5    DUSP10    DUSP6    DUSP16
    DUSP7    DUSP9    DUSP8

    DUSP2 for paralogs           About GeneDecksing



    Genomic Variants
    for DUSP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/89 NCBI SNPs in DUSP2 are shown (see all 89)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1829160621,2
    		--96808422(+) TGGGAA/GAAGAG 1 -- ds50010--------
    rs606262941,2
    		F,--96808509(+) ACACAC/TGCTCC 1 -- ds50011Minor allele frequency- T:0.17EA 120
    rs17241211,2
    		C,F,A,H,--96808549(-) GGCCCG/ATGCAC 1 -- ds50019Minor allele frequency- A:0.48EA NA WA CSA 1850
    rs1393183141,2
    		--96808574(+) CCACAC/GGACCA 1 -- ds50010--------
    rs750597881,2
    		--96808584(+) ACACCC/TTCAGG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1883637031,2
    		--96808599(+) CACTCA/GCATCC 1 -- ds50010--------
    rs1179762121,2
    		F,--96808667(+) AGTCAC/TGGACG 1 -- ds50011Minor allele frequency- T:0.06EA 120
    rs1141136161,2
    		F,--96808673(+) GGACGG/TGACCC 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1175484561,2
    		F,--96808756(+) AACTGG/CGGCCA 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs747204101,2
    		F,--96808768(+) GAGAGC/TAGCCT 1 -- ds50011Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for DUSP2 (96808905 - 96811179 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DUSP2: --

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    Disorders / Diseases
    for DUSP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DUSP2 for disorders           About GeneDecksing

    OMIM gene information: 603068    OMIM disorders: --

    20/30 diseases for DUSP2 (see all 30):    About MalaCards
    large granular lymphocyte leukemia    non-hodgkin lymphoma    type 2 diabetes mellitus    arteriosclerosis obliterans
    severe combined immunodeficiency    carotid stenosis    combined immunodeficiency    myocardial infarction
    acute myocardial infarction    hodgkin's lymphoma    diabetes mellitus    adult t-cell leukemia
    arteriosclerosis    lymphocytic leukemia    antiphospholipid syndrome    behcet's disease
    thrombosis    t-cell leukemia    leukemia    acute leukemia

    4 Novoseek disease relationships for DUSP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 31.1 1 16093733 (1)
    thrombosis 5.63 2 9814673 (1), 19741191 (1)
    shock 0 4 7681221 (1), 7585624 (1)
    tumors 0 2 12409223 (2)

    Human Genome Epidemiology (HuGE) Navigator: DUSP2 (4 documents)

    Export disorders for DUSP2 gene to outside databases

    Publications
    for DUSP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DUSP2 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with DUSP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. (PubMed id 7590752)1, 2, 3, 9 Yi H.... Kelly K. (1995)
    2. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. (PubMed id 12673251)1, 3, 9 Yin Y....Barrett J.C. (2003)
    3. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. (PubMed id 7681221)1, 2, 9 Rohan P.... Kelly K. (1993)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. (PubMed id 12575935)1, 2 Farooq A....Zhou M.M. (2003)
    6. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. (PubMed id 7806236)1, 3 Martell K.J....Trent J.M. (1994)
    7. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. (PubMed id 17471234)1, 9 Wu J....Yin Y. (2007)
    8. New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. (PubMed id 16288922)1, 9 Zhang Q....Zhou M.M. (2005)
    9. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. (PubMed id 8107850)1, 9 Ward Y....Kelly K. (1994)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for DUSP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing DUSP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1844 HGNC: 3068 AceView: DUSP2 Ensembl:ENSG00000158050 euGenes: HUgn1844
    ECgene: DUSP2 Kegg: 1844 H-InvDB: DUSP2

    Other Databases showing DUSP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DUSP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DUSP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DUSP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DUSP2 gene:
    Search GeneIP for patents involving DUSP2

    GeneCards and IP:
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