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Aliases for DUSP2 Gene

Aliases for DUSP2 Gene

  • Dual Specificity Phosphatase 2 2 3
  • PAC1 3 4 6
  • Dual Specificity Protein Phosphatase PAC-1 3 4
  • Serine/Threonine Specific Protein Phosphatase 3
  • Dual Specificity Protein Phosphatase 2 3
  • Dual-Specificity Phosphatase 2 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • PAC-1 3

External Ids for DUSP2 Gene

Previous GeneCards Identifiers for DUSP2 Gene

  • GC02M094680
  • GC02M095263
  • GC02M096276
  • GC02M096293
  • GC02M096230
  • GC02M096173
  • GC02M096808
  • GC02M090770

Summaries for DUSP2 Gene

Entrez Gene Summary for DUSP2 Gene

  • The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DUSP2 Gene

DUSP2 (Dual Specificity Phosphatase 2) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway. GO annotations related to this gene include protein tyrosine phosphatase activity and mitogen-activated protein kinase binding. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for DUSP2 Gene

  • Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2

Gene Wiki entry for DUSP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP2 Gene

Genomics for DUSP2 Gene

Regulatory Elements for DUSP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP2 Gene

Start:
96,143,166 bp from pter
End:
96,145,440 bp from pter
Size:
2,275 bases
Orientation:
Minus strand

Genomic View for DUSP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP2 Gene

Proteins for DUSP2 Gene

  • Protein details for DUSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05923-DUS2_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 2
    Protein Accession:
    Q05923
    Secondary Accessions:
    • Q53T45

    Protein attributes for DUSP2 Gene

    Size:
    314 amino acids
    Molecular mass:
    34400 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP2 Gene

neXtProt entry for DUSP2 Gene

Proteomics data for DUSP2 Gene at MOPED

Post-translational modifications for DUSP2 Gene

  • Ubiquitination at Lys157 and Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for DUSP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DUSP2 Gene

Domains for DUSP2 Gene

Gene Families for DUSP2 Gene

HGNC:
  • DUSPT :Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases

Suggested Antigen Peptide Sequences for DUSP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05923

UniProtKB/Swiss-Prot:

DUS2_HUMAN :
  • Q05923
Domain:
  • Contains 1 rhodanese domain.
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP2: view

Function for DUSP2 Gene

Molecular function for DUSP2 Gene

GENATLAS Biochemistry:
dual specificity (tyr/thr) phosphatase 2,expressed in hematopoietic tissues,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2
UniProtKB/Swiss-Prot Induction:
By mitogens

Enzyme Numbers (IUBMB) for DUSP2 Gene

Gene Ontology (GO) - Molecular Function for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 21784977
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0008330 protein tyrosine/threonine phosphatase activity TAS 8107850
genes like me logo Genes that share ontologies with DUSP2: view
genes like me logo Genes that share phenotypes with DUSP2: view

Animal Models for DUSP2 Gene

MGI Knock Outs for DUSP2:

Animal Model Products

miRNA for DUSP2 Gene

miRTarBase miRNAs that target DUSP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for DUSP2 Gene

Localization for DUSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP2 Gene COMPARTMENTS Subcellular localization image for DUSP2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DUSP2: view

Pathways for DUSP2 Gene

SuperPathways for DUSP2 Gene

Superpath Contained pathways
1 MAPK signaling pathway
genes like me logo Genes that share pathways with DUSP2: view

Pathways by source for DUSP2 Gene

1 KEGG pathway for DUSP2 Gene

Gene Ontology (GO) - Biological Process for DUSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8107850
GO:0001706 endoderm formation IBA --
GO:0006470 protein dephosphorylation IBA --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 7681221
genes like me logo Genes that share ontologies with DUSP2: view

Compounds for DUSP2 Gene

(3) HMDB Compounds for DUSP2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(14) Novoseek inferred chemical compound relationships for DUSP2 Gene

Compound -log(P) Hits PubMed IDs
cl 100 86.5 8
mdmp 85.8 1
pdmp 81.7 3
bisindolylmaleimide 52.4 1
fibrinogen 51.2 9
genes like me logo Genes that share compounds with DUSP2: view

Transcripts for DUSP2 Gene

mRNA/cDNA for DUSP2 Gene

(1) REFSEQ mRNAs :
(88) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DUSP2 Gene

Dual specificity phosphatase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP2 Gene

No ASD Table

Relevant External Links for DUSP2 Gene

GeneLoc Exon Structure for
DUSP2
ECgene alternative splicing isoforms for
DUSP2

Expression for DUSP2 Gene

mRNA expression in normal human tissues for DUSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP2 Gene

This gene is overexpressed in Whole Blood (9.5).

Protein differential expression in normal tissues for DUSP2 Gene

This gene is overexpressed in Breast (43.3) and Platelet (25.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DUSP2 Gene

SOURCE GeneReport for Unigene cluster for DUSP2 Gene Hs.1183

mRNA Expression by UniProt/SwissProt for DUSP2 Gene

Q05923-DUS2_HUMAN
Tissue specificity: Expressed in hematopoietic tissues
genes like me logo Genes that share expressions with DUSP2: view

Expression partners for DUSP2 Gene

In Situ Assay Products

Orthologs for DUSP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DUSP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP2 35
  • 88.32 (n)
  • 90.13 (a)
DUSP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP2 35
  • 89.07 (n)
  • 89.03 (a)
DUSP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp2 35
  • 85.24 (n)
  • 87.58 (a)
Dusp2 16
Dusp2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp2 35
  • 84.82 (n)
  • 88.54 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP2 36
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dusp2 35
  • 59.06 (n)
  • 54.66 (a)
dusp2 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for DUSP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP2 Gene

ENSEMBL:
Gene Tree for DUSP2 (if available)
TreeFam:
Gene Tree for DUSP2 (if available)

Paralogs for DUSP2 Gene

Paralogs for DUSP2 Gene

Selected SIMAP similar genes for DUSP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP2: view

Variants for DUSP2 Gene

Sequence variations from dbSNP and Humsavar for DUSP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1042361 -- 96,143,650(-) CTTTC(A/C/T)GACCT utr-variant-3-prime
rs1724120 -- 96,143,592(-) GAACC(A/G)AGGGT utr-variant-3-prime
rs1724121 -- 96,142,810(-) GGCCC(A/G)TGCAC downstream-variant-500B
rs2969489 -- 96,145,695(-) GTGCT(A/G)GTCCC upstream-variant-2KB
rs3813659 -- 96,147,080(-) CCAAG(G/T)TGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP2 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
dgv4247n71 CNV Loss 21882294
dgv4248n71 CNV Loss 21882294
nsv874677 CNV Loss 21882294

Relevant External Links for DUSP2 Gene

HapMap Linkage Disequilibrium report
DUSP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP2 Gene

Disorders for DUSP2 Gene

(4) Novoseek inferred disease relationships for DUSP2 Gene

Disease -log(P) Hits PubMed IDs
niddm 31.1 1
thrombosis 5.63 2
shock 0 2
tumors 0 2

Relevant External Links for DUSP2

Genetic Association Database (GAD)
DUSP2
Human Genome Epidemiology (HuGE) Navigator
DUSP2
genes like me logo Genes that share disorders with DUSP2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for DUSP2 Gene

Publications for DUSP2 Gene

  1. Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11. (PMID: 7590752) Yi H. … Kelly K. (Genomics 1995) 2 3 4 23
  2. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. (PMID: 7681221) Rohan P. … Kelly K. (Science 1993) 3 4 23
  3. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. (PMID: 12673251) Yin Y. … Barrett J.C. (Nature 2003) 2 3 23
  4. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. (PMID: 8107850) Ward Y. … Kelly K. (Nature 1994) 3 23
  5. New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. (PMID: 16288922) Zhang Q. … Zhou M.M. (J. Mol. Biol. 2005) 3 23

Products for DUSP2 Gene

Sources for DUSP2 Gene

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