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Aliases for DUSP19 Gene

Aliases for DUSP19 Gene

  • Dual Specificity Phosphatase 19 2 3 5
  • Stress-Activated Protein Kinase Pathway-Regulating Phosphatase 1 3 4
  • Low Molecular Weight Dual Specificity Phosphatase 3 3 4
  • SAPK Pathway-Regulating Phosphatase 1 3 4
  • Dual Specificity Phosphatase TS-DSP1 3 4
  • Protein Phosphatase SKRP1 3 4
  • LMWDSP3 3 4
  • DUSP17 3 4
  • SKRP1 3 4
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • LMW-DSP3 4
  • TS-DSP1 3

External Ids for DUSP19 Gene

Previous GeneCards Identifiers for DUSP19 Gene

  • GC02P182626
  • GC02P183907
  • GC02P184146
  • GC02P183768
  • GC02P183651
  • GC02P175802

Summaries for DUSP19 Gene

Entrez Gene Summary for DUSP19 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP19 Gene

DUSP19 (Dual Specificity Phosphatase 19) is a Protein Coding gene. Diseases associated with DUSP19 include ichthyosis, autosomal recessive 4b and epilepsy, progressive myoclonic 2b. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

UniProtKB/Swiss-Prot for DUSP19 Gene

  • Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Gene Wiki entry for DUSP19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP19 Gene

Genomics for DUSP19 Gene

Regulatory Elements for DUSP19 Gene

Enhancers for DUSP19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DUSP19 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DUSP19 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DUSP19 gene promoter:

Genomic Location for DUSP19 Gene

Chromosome:
2
Start:
183,078,224 bp from pter
End:
183,100,008 bp from pter
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for DUSP19 Gene

Genes around DUSP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP19 Gene

Proteins for DUSP19 Gene

  • Protein details for DUSP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR2-DUS19_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 19
    Protein Accession:
    Q8WTR2
    Secondary Accessions:
    • B2RA79
    • Q547H4
    • Q8WYN4

    Protein attributes for DUSP19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24194 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP19 Gene

    Alternative splice isoforms for DUSP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP19 Gene

Proteomics data for DUSP19 Gene at MOPED

Post-translational modifications for DUSP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP19 Gene

Antibody Products

No data available for DME Specific Peptides for DUSP19 Gene

Domains & Families for DUSP19 Gene

Gene Families for DUSP19 Gene

Suggested Antigen Peptide Sequences for DUSP19 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WTR2

UniProtKB/Swiss-Prot:

DUS19_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP19: view

Function for DUSP19 Gene

Molecular function for DUSP19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Enzyme Numbers (IUBMB) for DUSP19 Gene

Gene Ontology (GO) - Molecular Function for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0008579 JUN kinase phosphatase activity IBA --
GO:0016791 phosphatase activity IEA --
GO:0031435 mitogen-activated protein kinase kinase kinase binding ISS --
genes like me logo Genes that share ontologies with DUSP19: view
genes like me logo Genes that share phenotypes with DUSP19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP19

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP19 Gene

Localization for DUSP19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP19 Gene COMPARTMENTS Subcellular localization image for DUSP19 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP19 Gene

Pathways & Interactions for DUSP19 Gene

SuperPathways for DUSP19 Gene

No Data Available

SIGNOR curated interactions for DUSP19 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0032147 activation of protein kinase activity ISS --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0043507 positive regulation of JUN kinase activity ISS --
genes like me logo Genes that share ontologies with DUSP19: view

No data available for Pathways by source for DUSP19 Gene

Drugs & Compounds for DUSP19 Gene

(57) Drugs for DUSP19 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(69) Additional Compounds for DUSP19 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DUSP19: view

Transcripts for DUSP19 Gene

Unigene Clusters for DUSP19 Gene

Dual specificity phosphatase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -
SP3: -

Relevant External Links for DUSP19 Gene

GeneLoc Exon Structure for
DUSP19
ECgene alternative splicing isoforms for
DUSP19

Expression for DUSP19 Gene

mRNA expression in normal human tissues for DUSP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP19 Gene

This gene is overexpressed in Fetal Brain (52.8) and Retina (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP19 Gene



SOURCE GeneReport for Unigene cluster for DUSP19 Gene Hs.132237

mRNA Expression by UniProt/SwissProt for DUSP19 Gene

Q8WTR2-DUS19_HUMAN
Tissue specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.
genes like me logo Genes that share expression patterns with DUSP19: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DUSP19 Gene

Orthologs for DUSP19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP19 35
  • 92.52 (n)
  • 91.59 (a)
DUSP19 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP19 35
  • 84.34 (n)
  • 81.86 (a)
DUSP19 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp19 35
  • 86.26 (n)
  • 84.83 (a)
Dusp19 16
Dusp19 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP19 35
  • 99.4 (n)
  • 100 (a)
DUSP19 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp19 35
  • 84.2 (n)
  • 82.46 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP19 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP19 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP19 35
  • 70.83 (n)
  • 78.5 (a)
DUSP19 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP19 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp19 35
  • 71.62 (n)
  • 70.79 (a)
Str.15392 35
zebrafish
(Danio rerio)
Actinopterygii dusp19a 35
  • 64.49 (n)
  • 64.82 (a)
dusp19a 36
  • 60 (a)
OneToMany
dusp19b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mkp 35
  • 50.75 (n)
  • 44.94 (a)
Mkp 36
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DSPTP1 35
  • 51.69 (n)
  • 42.03 (a)
rice
(Oryza sativa)
Liliopsida Os01g0390900 35
  • 50.51 (n)
  • 45.38 (a)
Species with no ortholog for DUSP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP19 Gene

ENSEMBL:
Gene Tree for DUSP19 (if available)
TreeFam:
Gene Tree for DUSP19 (if available)

Paralogs for DUSP19 Gene

(13) SIMAP similar genes for DUSP19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP19: view

Variants for DUSP19 Gene

Sequence variations from dbSNP and Humsavar for DUSP19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs16823987 - 183,095,652(+) AACAG(G/T)TCATG reference, missense, utr-variant-3-prime
rs1812647 -- 183,100,312(-) acctc(C/T)gcctc downstream-variant-500B
rs1850251 -- 183,085,990(-) ATTAA(A/G)ATAAT intron-variant
rs925805 -- 183,079,366(-) GCTAC(C/G)AGAAT intron-variant
rs2944344 -- 183,077,055(+) ctttt(C/T)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DUSP19 Gene

Variant ID Type Subtype PubMed ID
nsv875485 CNV Gain 21882294

Variation tolerance for DUSP19 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP19 Gene

HapMap Linkage Disequilibrium report
DUSP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP19 Gene

Disorders for DUSP19 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DUSP19 Gene - From: Novoseek

Disorder Aliases PubMed IDs
ichthyosis, autosomal recessive 4b
  • harlequin type ichthyosis
epilepsy, progressive myoclonic 2b
  • epilepsy, progressive myoclonic 2a
cowden disease
  • dysplastic gangliocytoma of cerebellum
osteochondroma
  • cartilaginous exostosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP19
genes like me logo Genes that share disorders with DUSP19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP19 Gene

Publications for DUSP19 Gene

  1. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. (PMID: 12479873) Cheng H. … Mao Y. (Int. J. Biochem. Cell Biol. 2003) 3 4 23 67
  2. Dual-specificity phosphatases: critical regulators with diverse cellular targets. (PMID: 19228121) Patterson K.I. … Daly R.J. (Biochem. J. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for DUSP19 Gene

Sources for DUSP19 Gene

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