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Aliases for DUSP19 Gene

Aliases for DUSP19 Gene

  • Dual Specificity Phosphatase 19 2 3 5
  • Stress-Activated Protein Kinase Pathway-Regulating Phosphatase 1 3 4
  • Low Molecular Weight Dual Specificity Phosphatase 3 3 4
  • SAPK Pathway-Regulating Phosphatase 1 3 4
  • Dual Specificity Phosphatase TS-DSP1 3 4
  • Protein Phosphatase SKRP1 3 4
  • LMWDSP3 3 4
  • DUSP17 3 4
  • SKRP1 3 4
  • Dual Specificity Protein Phosphatase 19 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • LMW-DSP3 4
  • TS-DSP1 3

External Ids for DUSP19 Gene

Previous GeneCards Identifiers for DUSP19 Gene

  • GC02P182626
  • GC02P183907
  • GC02P184146
  • GC02P183768
  • GC02P183651
  • GC02P175802

Summaries for DUSP19 Gene

Entrez Gene Summary for DUSP19 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP19 Gene

DUSP19 (Dual Specificity Phosphatase 19) is a Protein Coding gene. Diseases associated with DUSP19 include Cowden Disease and Osteochondroma. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is STYX.

UniProtKB/Swiss-Prot for DUSP19 Gene

  • Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Gene Wiki entry for DUSP19 Gene

Additional gene information for DUSP19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP19 Gene

Genomics for DUSP19 Gene

Regulatory Elements for DUSP19 Gene

Enhancers for DUSP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H183123 1.1 ENCODE 18 +46.9 46859 3 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 DUSP19 NUP35 LOC105373774 GC02P183146
GH02H183078 1.1 ENCODE 8 +0.9 878 1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS NFYC REST NCKAP1 NUP35 ENSG00000224643 DUSP19 FRZB
GH02H182866 0.8 ENCODE 5.2 -210.9 -210875 2 ELF3 SAP130 SUZ12 ZFP64 MAX ZNF384 ZIC2 GATA2 ZNF600 NR2F6 FRZB DUSP19 GC02P182874
GH02H183063 0.6 FANTOM5 2.3 -15.0 -14968 0 RFX1 JUN FOXJ2 ZBTB40 NUP35 DUSP19 ENSG00000221498 GC02M183065 GC02P183062
GH02H183091 0.7 ENCODE 0.4 +13.3 13314 0 DRAP1 FOXA2 ATF1 SAP130 ARID4B NFYC DMAP1 ZNF644 POLR2A HNF4A ENSG00000221498 NUP35 DUSP19 ENSG00000224643
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DUSP19 on UCSC Golden Path with GeneCards custom track

Promoters for DUSP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000127371 677 1799 PKNOX1 SIN3A ARID4B DMAP1 ZNF2 YY1 FOS NFYC REST ZNF592

Transcription factor binding sites by QIAGEN in the DUSP19 gene promoter:

Genomic Location for DUSP19 Gene

Chromosome:
2
Start:
183,078,224 bp from pter
End:
183,100,008 bp from pter
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for DUSP19 Gene

Genes around DUSP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DUSP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DUSP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP19 Gene

Proteins for DUSP19 Gene

  • Protein details for DUSP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR2-DUS19_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 19
    Protein Accession:
    Q8WTR2
    Secondary Accessions:
    • B2RA79
    • Q547H4
    • Q8WYN4

    Protein attributes for DUSP19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24194 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP19 Gene

    Alternative splice isoforms for DUSP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP19 Gene

Post-translational modifications for DUSP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP19 Gene

No data available for DME Specific Peptides for DUSP19 Gene

Domains & Families for DUSP19 Gene

Gene Families for DUSP19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DUSP19 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WTR2

UniProtKB/Swiss-Prot:

DUS19_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP19: view

Function for DUSP19 Gene

Molecular function for DUSP19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Enzyme Numbers (IUBMB) for DUSP19 Gene

Gene Ontology (GO) - Molecular Function for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004860 protein kinase inhibitor activity ISS --
GO:0005078 MAP-kinase scaffold activity ISS --
GO:0005515 protein binding IPI 21516116
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP19: view
genes like me logo Genes that share phenotypes with DUSP19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DUSP19

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DUSP19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DUSP19 Gene

Localization for DUSP19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DUSP19 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DUSP19 Gene

Pathways & Interactions for DUSP19 Gene

SuperPathways for DUSP19 Gene

No Data Available

SIGNOR curated interactions for DUSP19 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0006470 protein dephosphorylation IEA --
GO:0016311 dephosphorylation IEA --
GO:0032147 activation of protein kinase activity IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
genes like me logo Genes that share ontologies with DUSP19: view

No data available for Pathways by source for DUSP19 Gene

Drugs & Compounds for DUSP19 Gene

(65) Drugs for DUSP19 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Calyculin A Experimental Pharma Protein phosphatase inhibitor, Protein phosphatase 1 and 2A inhibitor 0
Okadaic acid Experimental Pharma Protein phosphatase 1 inhibitor, Protein phosphatase 1 and 2A inhibitor 0
Ceramide Pharma Protein phosphatase and CAPP modulator 0

(62) Additional Compounds for DUSP19 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2

(5) ApexBio Compounds for DUSP19 Gene

Compound Action Cas Number
Calyculin A Protein phosphatase inhibitor 101932-71-2
Ceramide Protein phosphatase and CAPP modulator 3102-57-6
Fostriecin sodium salt Antitumor antibiotic 87860-39-7
Okadaic acid Protein phosphatase 1 inhibitor 78111-17-8
Tautomycetin 119757-73-2
genes like me logo Genes that share compounds with DUSP19: view

Drug Products

Transcripts for DUSP19 Gene

Unigene Clusters for DUSP19 Gene

Dual specificity phosphatase 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DUSP19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -
SP3: -

Relevant External Links for DUSP19 Gene

GeneLoc Exon Structure for
DUSP19
ECgene alternative splicing isoforms for
DUSP19

Expression for DUSP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DUSP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DUSP19 Gene

This gene is overexpressed in Fetal Brain (52.8) and Retina (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DUSP19 Gene



NURSA nuclear receptor signaling pathways regulating expression of DUSP19 Gene:

DUSP19

SOURCE GeneReport for Unigene cluster for DUSP19 Gene:

Hs.132237

mRNA Expression by UniProt/SwissProt for DUSP19 Gene:

Q8WTR2-DUS19_HUMAN
Tissue specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.

Evidence on tissue expression from TISSUES for DUSP19 Gene

  • Liver(4)
genes like me logo Genes that share expression patterns with DUSP19: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DUSP19 Gene

Orthologs for DUSP19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DUSP19 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia DUSP19 33 34
  • 92.52 (n)
oppossum
(Monodelphis domestica)
Mammalia DUSP19 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp19 33 16 34
  • 86.26 (n)
dog
(Canis familiaris)
Mammalia DUSP19 33 34
  • 84.34 (n)
rat
(Rattus norvegicus)
Mammalia Dusp19 33
  • 84.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP19 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP19 33 34
  • 70.83 (n)
lizard
(Anolis carolinensis)
Reptilia DUSP19 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp19 33
  • 71.62 (n)
Str.15392 33
zebrafish
(Danio rerio)
Actinopterygii dusp19a 33 34
  • 64.49 (n)
dusp19b 34
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mkp 33 34
  • 50.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DSPTP1 33
  • 51.69 (n)
rice
(Oryza sativa)
Liliopsida Os01g0390900 33
  • 50.51 (n)
Species where no ortholog for DUSP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP19 Gene

ENSEMBL:
Gene Tree for DUSP19 (if available)
TreeFam:
Gene Tree for DUSP19 (if available)

Paralogs for DUSP19 Gene

(13) SIMAP similar genes for DUSP19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP19: view

Variants for DUSP19 Gene

Sequence variations from dbSNP and Humsavar for DUSP19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000277081 -- 183,086,522(+) AATAT(A/G)TAGGC intron-variant
rs1000360660 -- 183,099,968(+) CTTCT(A/G)GTTGA nc-transcript-variant, utr-variant-3-prime
rs1000375440 -- 183,099,842(+) AAATA(C/G)AAAAA nc-transcript-variant, utr-variant-3-prime
rs1000391708 -- 183,099,683(+) ACTTA(C/T)TTGCT nc-transcript-variant, utr-variant-3-prime
rs1000550865 -- 183,080,074(+) CACAA(G/T)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP19 Gene

Variant ID Type Subtype PubMed ID
esv2763287 CNV gain+loss 21179565
esv3593580 CNV gain 21293372
esv3893517 CNV gain+loss 25118596
nsv1009882 CNV gain 25217958

Variation tolerance for DUSP19 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DUSP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DUSP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP19 Gene

Disorders for DUSP19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DUSP19 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
cowden disease
  • dysplastic gangliocytoma of cerebellum
osteochondroma
  • cartilaginous exostosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DUSP19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DUSP19
genes like me logo Genes that share disorders with DUSP19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DUSP19 Gene

Publications for DUSP19 Gene

  1. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. (PMID: 12479873) Cheng H … Mao Y (The international journal of biochemistry & cell biology 2003) 3 4 22 60
  2. Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. (PMID: 21989941) Wei CH … Ryu SE (Proteins 2011) 3 4 60
  3. Dual-specificity phosphatases: critical regulators with diverse cellular targets. (PMID: 19228121) Patterson KI … Daly RJ (The Biochemical journal 2009) 3 22 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for DUSP19 Gene

Sources for DUSP19 Gene

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