Aliases for DUSP19 Gene
External Ids for DUSP19 Gene
Previous GeneCards Identifiers for DUSP19 Gene
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
GeneCards Summary for DUSP19 Gene
DUSP19 (Dual Specificity Phosphatase 19) is a Protein Coding gene. Diseases associated with DUSP19 include ichthyosis, autosomal recessive 4b and epilepsy, progressive myoclonic 2b. GO annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.
UniProtKB/Swiss-Prot for DUSP19 Gene
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.