Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DUSP19 Gene

Aliases for DUSP19 Gene

  • Dual Specificity Phosphatase 19 2 3
  • Stress-Activated Protein Kinase Pathway-Regulating Phosphatase 1 3 4
  • Low Molecular Weight Dual Specificity Phosphatase 3 3 4
  • SAPK Pathway-Regulating Phosphatase 1 3 4
  • Dual Specificity Phosphatase TS-DSP1 3 4
  • Protein Phosphatase SKRP1 3 4
  • LMW-DSP3 3 4
  • LMWDSP3 3 4
  • DUSP17 3 4
  • SKRP1 3 4
  • Dual Specificity Protein Phosphatase 19 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • TS-DSP1 3

External Ids for DUSP19 Gene

Previous GeneCards Identifiers for DUSP19 Gene

  • GC02P182626
  • GC02P183907
  • GC02P184146
  • GC02P183768
  • GC02P183651
  • GC02P175802

Summaries for DUSP19 Gene

Entrez Gene Summary for DUSP19 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP19 Gene

DUSP19 (Dual Specificity Phosphatase 19) is a Protein Coding gene. Diseases associated with DUSP19 include osteochondroma and neuroblastoma. GO annotations related to this gene include protein tyrosine phosphatase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for DUSP19 Gene

  • Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Gene Wiki entry for DUSP19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP19 Gene

Genomics for DUSP19 Gene

Regulatory Elements for DUSP19 Gene

Transcription factor binding sites by QIAGEN in the DUSP19 gene promoter:

Genomic Location for DUSP19 Gene

Start:
183,078,559 bp from pter
End:
183,100,008 bp from pter
Size:
21,450 bases
Orientation:
Plus strand

Genomic View for DUSP19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP19 Gene

Proteins for DUSP19 Gene

  • Protein details for DUSP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTR2-DUS19_HUMAN
    Recommended name:
    Dual specificity protein phosphatase 19
    Protein Accession:
    Q8WTR2
    Secondary Accessions:
    • B2RA79
    • Q547H4
    • Q8WYN4

    Protein attributes for DUSP19 Gene

    Size:
    217 amino acids
    Molecular mass:
    24194 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP19 Gene

    Alternative splice isoforms for DUSP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DUSP19 Gene

Proteomics data for DUSP19 Gene at MOPED

Post-translational modifications for DUSP19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DUSP19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DUSP19 Gene

Domains for DUSP19 Gene

Gene Families for DUSP19 Gene

HGNC:
  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUSP19 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WTR2

UniProtKB/Swiss-Prot:

DUS19_HUMAN :
  • Q8WTR2
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP19: view

Function for DUSP19 Gene

Molecular function for DUSP19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Enzyme Numbers (IUBMB) for DUSP19 Gene

Gene Ontology (GO) - Molecular Function for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0004860 protein kinase inhibitor activity ISS --
GO:0005078 MAP-kinase scaffold activity ISS --
GO:0005515 protein binding IPI 21516116
GO:0008138 protein tyrosine/serine/threonine phosphatase activity --
genes like me logo Genes that share ontologies with DUSP19: view

Phenotypes for DUSP19 Gene

genes like me logo Genes that share phenotypes with DUSP19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP19

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DUSP19 Gene

Localization for DUSP19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DUSP19 Gene COMPARTMENTS Subcellular localization image for DUSP19 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DUSP19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DUSP19 Gene

Pathways for DUSP19 Gene

SuperPathways for DUSP19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DUSP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0006470 protein dephosphorylation IBA --
GO:0007254 JNK cascade IBA --
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with DUSP19: view

No data available for Pathways by source for DUSP19 Gene

Compounds for DUSP19 Gene

(3) HMDB Compounds for DUSP19 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(123) Novoseek inferred chemical compound relationships for DUSP19 Gene

Compound -log(P) Hits PubMed IDs
okadaic acid 96 129
calyculin a 94.5 101
tautomycin 88.8 19
microcystin-lr 85 21
threonine 84.1 45
genes like me logo Genes that share compounds with DUSP19: view

Transcripts for DUSP19 Gene

Unigene Clusters for DUSP19 Gene

Dual specificity phosphatase 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: - -
SP3: -

Relevant External Links for DUSP19 Gene

GeneLoc Exon Structure for
DUSP19
ECgene alternative splicing isoforms for
DUSP19

Expression for DUSP19 Gene

mRNA expression in normal human tissues for DUSP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DUSP19 Gene

This gene is overexpressed in Fetal Brain (52.8) and Retina (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP19 Gene

SOURCE GeneReport for Unigene cluster for DUSP19 Gene Hs.132237

mRNA Expression by UniProt/SwissProt for DUSP19 Gene

Q8WTR2-DUS19_HUMAN
Tissue specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.
genes like me logo Genes that share expressions with DUSP19: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for DUSP19 Gene

Orthologs for DUSP19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DUSP19 35
  • 92.52 (n)
  • 91.59 (a)
DUSP19 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DUSP19 35
  • 84.34 (n)
  • 81.86 (a)
DUSP19 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dusp19 35
  • 86.26 (n)
  • 84.83 (a)
Dusp19 16
Dusp19 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DUSP19 35
  • 99.4 (n)
  • 100 (a)
DUSP19 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dusp19 35
  • 84.2 (n)
  • 82.46 (a)
oppossum
(Monodelphis domestica)
Mammalia DUSP19 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DUSP19 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DUSP19 35
  • 70.83 (n)
  • 78.5 (a)
DUSP19 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DUSP19 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp19 35
  • 71.62 (n)
  • 70.79 (a)
Str.15392 35
zebrafish
(Danio rerio)
Actinopterygii dusp19a 35
  • 64.49 (n)
  • 64.82 (a)
dusp19a 36
  • 60 (a)
OneToMany
dusp19b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mkp 35
  • 50.75 (n)
  • 44.94 (a)
Mkp 36
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DSPTP1 35
  • 51.69 (n)
  • 42.03 (a)
rice
(Oryza sativa)
Liliopsida Os01g0390900 35
  • 50.51 (n)
  • 45.38 (a)
Species with no ortholog for DUSP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DUSP19 Gene

ENSEMBL:
Gene Tree for DUSP19 (if available)
TreeFam:
Gene Tree for DUSP19 (if available)

Paralogs for DUSP19 Gene

Selected SIMAP similar genes for DUSP19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DUSP19: view

Variants for DUSP19 Gene

Sequence variations from dbSNP and Humsavar for DUSP19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs925805 -- 183,079,366(-) GCTAC(C/G)AGAAT intron-variant
rs1516242 -- 183,092,034(-) GCAGA(A/G)GTCTG intron-variant
rs1812647 -- 183,100,312(-) acctc(C/T)gcctc downstream-variant-500B
rs1850251 -- 183,085,990(-) ATTAA(A/G)ATAAT intron-variant
rs2138482 -- 183,090,005(-) CTTGA(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP19 Gene

Variant ID Type Subtype PubMed ID
nsv875485 CNV Gain 21882294

Relevant External Links for DUSP19 Gene

HapMap Linkage Disequilibrium report
DUSP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP19 Gene

Disorders for DUSP19 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DUSP19 Gene in MalaCards »

(3) Diseases for DUSP19 Gene including...

(59) Novoseek inferred disease relationships for DUSP19 Gene

Disease -log(P) Hits PubMed IDs
paired helical filament 59.2 1
lafora disease 53.8 2
harlequin ichthyosis 45.4 3
retinoblastoma 42.3 6
neurofibrillary tangles 41.9 3
genes like me logo Genes that share disorders with DUSP19: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for DUSP19 Gene

Publications for DUSP19 Gene

  1. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. (PMID: 12479873) Cheng H. … Mao Y. (Int. J. Biochem. Cell Biol. 2003) 3 4 23
  2. Dual-specificity phosphatases: critical regulators with diverse cellular targets. (PMID: 19228121) Patterson K.I. … Daly R.J. (Biochem. J. 2009) 3 23
  3. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. (PMID: 11959862) Zama T. … Hagiwara M. (J. Biol. Chem. 2002) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DUSP19 Gene

Sources for DUSP19 Gene

Back to Top

Content