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DUSP19 Gene

protein-coding   GIFtS: 54
GCID: GC02P183907

Dual Specificity Phosphatase 19

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dual Specificity Phosphatase 191 2     LMWDSP32 3
Dual Specificity Phosphatase TS-DSP12 3     SKRP12 3
Low Molecular Weight Dual Specificity Phosphatase 32 3     SAPK Pathway-Regulating Phosphatase 12 3
Protein Phosphatase SKRP12 3     TS-DSP12
Stress-Activated Protein Kinase Pathway-Regulating Phosphatase 12 3     Dual Specificity Protein Phosphatase 192
DUSP172 3     EC 3.1.3.163
LMW-DSP32 3     EC 3.1.3.483

External Ids:    HGNC: 188941   Entrez Gene: 1426792   Ensembl: ENSG000001629997   OMIM: 6114375   UniProtKB: Q8WTR23   

Export aliases for DUSP19 gene to outside databases

Previous GC identifers: GC02P182626 GC02P184146 GC02P183768 GC02P183651 GC02P175802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP19 Gene:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based
protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both
tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling
pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine
residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein
kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 (PubMed
19228121)).(supplied by OMIM, Dec 2009)

GeneCards Summary for DUSP19 Gene:
DUSP19 (dual specificity phosphatase 19) is a protein-coding gene. Diseases associated with DUSP19 include congenital cataracts, facial dysmorphism, and neuropathy, and lafora disease. GO annotations related to this gene include protein tyrosine phosphatase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: DUS19_HUMAN, Q8WTR2
Function: Has a dual specificity toward Ser/Thr and Tyr-containing proteins

Gene Wiki entry for DUSP19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP19 gene promoter:
         STAT1   AML1a   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DUSP19 promoter sequence
   Search Chromatin IP Primers for DUSP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q32.1

DUSP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP19 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P183907:  view genomic region     (about GC identifiers)

Start:
183,943,287 bp from pter      End:
183,964,736 bp from pter
Size:
21,450 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DUS19_HUMAN, Q8WTR2 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 19  
Size: 217 amino acids; 24194 Da
1 PDB 3D structure from and Proteopedia for DUSP19:
3S4E (3D)    
Secondary accessions: B2RA79 Q547H4 Q8WYN4
Alternative splicing: 2 isoforms:  Q8WTR2-1   Q8WTR2-2   

Explore the universe of human proteins at neXtProt for DUSP19: NX_Q8WTR2

Explore proteomics data for DUSP19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DUSP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135786.1  NP_543152.1  

    ENSEMBL proteins: 
     ENSP00000343905   ENSP00000346160  

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    LSBio Antibodies in human, mouse, rat for DUSP19

    DUSP19 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    5 InterPro protein domains:
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR020417 Atypical_DUSP
     IPR024950 DUSP
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q8WTR2

    ProtoNet protein and cluster: Q8WTR2

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: DUS19_HUMAN, Q8WTR2
    Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    DUSP19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUS19_HUMAN, Q8WTR2
    Function: Has a dual specificity toward Ser/Thr and Tyr-containing proteins
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0004860protein kinase inhibitor activity ISS--
    GO:0005078MAP-kinase scaffold activity ISS--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity ----
         
    DUSP19 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DUSP19:
     Increased Akt phosphorylation   Increased S DNA content  Increased apoptosis 

         1 MGI phenotypic allele for Dusp19 (no phenotypes)

    DUSP19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dusp19tm1Lex for DUSP19

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DUSP19
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DUSP19 (see all 38):
    hsa-miR-576-3p hsa-miR-19b-2* hsa-miR-139-5p hsa-let-7a-2* hsa-miR-3653 hsa-miR-374a hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidDUSP19 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DUSP19
    Predesigned siRNA for gene silencing in human, mouse, rat DUSP19

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DUSP19 (NM_080876)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    DUSP19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUSP19
    Interactions:

        GeneGlobe Interaction Network for DUSP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for DUSP19 (Q8WTR23 ENSP000003461604) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147333, ENSP000003810664I2D: score=3 STRING: ENSP00000381066
    MAP3K5Q996833, ENSP000003519084I2D: score=3 STRING: ENSP00000351908
    MAPK9P459843, ENSP000003214104I2D: score=2 STRING: ENSP00000321410
    ALAS1P131963I2D: score=1 
    MAP2K2ENSP000002629484STRING: ENSP00000262948
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IEA--
    GO:0006469negative regulation of protein kinase activity ISS--
    GO:0006470protein dephosphorylation IBA--
    GO:0007254JNK cascade IBA--
    GO:0016311dephosphorylation ----

    DUSP19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DUSP19 (DUS19)

    3 HMDB Compounds for DUSP19    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for DUSP19 gene (see all 123)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    okadaic acid 96 319 1328535 (3), 1663450 (3), 7698228 (3), 7927883 (3) (see all 99)
    calyculin a 94.5 123 12802629 (2), 10522205 (2), 7931558 (2), 8581989 (2) (see all 92)
    tautomycin 88.8 20 9605423 (3), 10493981 (2), 1556018 (2), 8581989 (2) (see all 14)
    microcystin-lr 85 25 16046071 (2), 12176093 (2), 11137546 (1), 10669024 (1) (see all 19)
    threonine 84.1 47 7771789 (2), 1384163 (1), 11875759 (1), 17030510 (1) (see all 44)
    serine 78.1 52 7771789 (2), 7566342 (1), 11875759 (1), 17030510 (1) (see all 48)
    fostriecin 78.1 4 12536807 (1), 14677930 (1), 12624107 (1), 9215602 (1)
    motuporin 74.1 1 7749913 (1)
    cantharidin 74.1 6 12559002 (1), 15807782 (1), 15667592 (1), 9809469 (1) (see all 6)
    nodularin 73.8 8 15892066 (1), 10669024 (1), 16304634 (1), 10578179 (1) (see all 8)



    DUSP19 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DUSP19 gene (2 alternative transcripts): 
    NM_001142314.1  NM_080876.3  

    Unigene Cluster for DUSP19:

    Dual specificity phosphatase 19
    Hs.132237  [show with all ESTs]
    Unigene Representative Sequence: NM_080876
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342619 ENST00000354221(uc002upd.3 uc010frp.3 uc010zfr.2 uc002upe.3)
    ENST00000469344
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DUSP19 (see all 38):
    hsa-miR-576-3p hsa-miR-19b-2* hsa-miR-139-5p hsa-let-7a-2* hsa-miR-3653 hsa-miR-374a hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidDUSP19 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DUSP19

    Additional mRNA sequence: 

    AB038770.1 AB063186.1 AB063187.1 AK094800.1 AK125657.1 AK314078.1 BC035000.1 BC093958.1 
    BC112005.1 BC143337.1 BX647818.1 

    4 DOTS entries:

    DT.205994  DT.100016082  DT.97835667  DT.99940729 

    Selected AceView cDNA sequences (see all 31):

    AB038770 BX496415 AB063187 CA776730 BG116871 BX647818 AW772089 AF486808 
    NM_080876 AK094800 AI031656 AK125657 BU160622 BX111317 AI025365 AA442646 
    AA442636 BX957037 AB063186 BC035000 CA776500 N63762 AW172742 AI033989 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DUSP19    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
    SP1:                                    
    SP2:                    -     -         
    SP3:                    -               


    ECgene alternative splicing isoforms for DUSP19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DUSP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCTTTAT
    DUSP19 Expression
    About this image


    DUSP19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    DUSP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DUSP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132237

    UniProtKB/Swiss-Prot: DUS19_HUMAN, Q8WTR2
    Tissue specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the
    highest

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DUSP19 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dusp191 , 5 dual specificity phosphatase 191, 5 86.26(n)1
    84.83(a)1
      2 (48.31 cM)5
    680821  NM_024438.41  NP_077758.11 
     806170455 
    chicken
    (Gallus gallus)
    Aves DUSP191 dual specificity phosphatase 19 70.83(n)
    78.5(a)
      423999  XM_421855.4  XP_421855.2 
    lizard
    (Anolis carolinensis)
    Reptilia DUSP196
    dual specificity phosphatase 19
    75(a)
    1 ↔ 1
    GL343221.1(1883391-1907099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.153922 Transcribed sequence with weak similarity to protein more 73.78(n)    BX704055.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dusp19a1 dual specificity phosphatase 19a 64.49(n)
    64.82(a)
      792815  NM_001128265.1  NP_001121737.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mkp1 MAP kinase-specific phosphatase 50.75(n)
    44.94(a)
      4379907  NM_001043107.1  NP_001036572.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DSPTP11 DSPTP1 51.69(n)
    42.03(a)
      821941  NM_113265.1  NP_189003.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g03909001 Os01g0390900 50.51(n)
    45.38(a)
      4325232  NM_001049647.1  NP_001043112.1 


    ENSEMBL Gene Tree for DUSP19 (if available)
    TreeFam Gene Tree for DUSP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DUSP19 gene
    DUSP262  DUSP212  DUPD12  DUSP32  DUSP132  DUSP272  STYX2  DUSP142  
    DUSP282  DUSP152  DUSP222  DUSP182  
    13 SIMAP similar genes for DUSP19 using alignment to 1 protein entry:     DUS19_HUMAN:
    DUSP10    DUSP6    DUSP7    SSH3    DUSP15    DUSP18
    SSH2    DUSP21    SSH1    STYX    DUSP9    DUSP3
    DUSP22

    DUSP19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DUSP19 (see all 415)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489886061,2
    --183941361(+) TATTCA/GTTAAC 2 -- us2k10--------
    rs26750431,2
    C,F,A,H--183941444(+) GGTTTT/CATTTG 2 -- us2k116Minor allele frequency- C:0.11NS EA NA CSA WA 2136
    rs1118706521,2
    F--183941471(+) TAGGGG/ATGAGG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs2015112581,2
    C--183941778(+) CTTTTC/TTTTTT 2 -- us2k10--------
    rs29443441,2
    C,A--183941783(+) cttttC/Tttttt 2 -- us2k1 trp30--------
    rs23683541,2
    C,H--183942007(+) GTCTCC/GAACTC 2 -- us2k15Minor allele frequency- G:0.00NA 12
    rs1385876191,2
    --183942064(+) TTACAG/TGCATG 2 -- us2k10--------
    rs26750861,2
    C,F,H--183942093(-) GAAAAG/AGGAAT 2 -- us2k1 trp318Minor allele frequency- A:0.02NS EA WA NA CSA 1177
    rs1440946721,2
    --183942179(+) ACAACC/TGAAAT 2 -- us2k10--------
    rs1829904241,2
    --183942582(+) TTTTCA/GTAAGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DUSP19 (183943287 - 183964736 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DUSP19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875485CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DUSP19
    DNA2.0 Custom Variant and Variant Library Synthesis for DUSP19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611437    OMIM disorders: --

    Selected diseases for DUSP19 (see all 68):    
    About MalaCards
    congenital cataracts, facial dysmorphism, and neuropathy    lafora disease    osteochondroma    cowden disease
    cystic teratoma    myoclonus epilepsy    fibrous histiocytoma    progressive myoclonus epilepsy
    myoclonus    histiocytoma    differentiating neuroblastoma    neuroepithelioma
    teratoma    lipoma    liposarcoma    brain disease
    brain ischemia    chondrosarcoma    ischemia    cystic fibrosis


    DUSP19 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for DUSP19 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 59.2 1 9129864 (1)
    lafora disease 53.8 2 16311711 (1), 16971387 (1)
    harlequin ichthyosis 45.4 3 7694551 (2), 9470902 (1)
    retinoblastoma 42.3 6 11593419 (1), 10874474 (1), 7499444 (1), 8663484 (1) (see all 6)
    neurofibrillary tangles 41.9 3 18430997 (1), 8720139 (1), 18852562 (1)
    cowden disease 41.8 1 10051603 (1)
    alzheimers disease 35.9 13 7616230 (2), 7787767 (1), 8624075 (1), 16953147 (1) (see all 12)
    glioblastoma 32.5 2 16294307 (1), 19915616 (1)
    myeloid leukemia 32 6 8389250 (1), 1334850 (1), 18796247 (1), 9204972 (1) (see all 6)
    promyelocytic leukemia 24.8 1 9894151 (1)


    Export disorders for DUSP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DUSP19 gene, integrated from 10 sources (see all 830):
    (articles sorted by number of sources associating them with DUSP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. (PubMed id 12479873)1, 2, 9 Cheng H.... Mao Y. (Int. J. Biochem. Cell Biol. 2003)
    2. Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. (PubMed id 21989941)1, 2 Wei C.H....Ryu S.E. (Proteins 2011)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. (PubMed id 11959862)1, 2 Zama T.... Hagiwara M. (J. Biol. Chem. 2002)
    7. Dual-specificity phosphatases: critical regulators with diverse cellular targets. (PubMed id 19228121)1, 9 Patterson K.I....Daly R.J. (Biochem. J. 2009)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. (PubMed id 11959861)1 Zama T....Hagiwara M. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 142679 HGNC: 18894 AceView: DUSP19 Ensembl:ENSG00000162999 euGenes: HUgn142679
    ECgene: DUSP19 H-InvDB: DUSP19

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DUSP19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DUSP19 gene:
    Search GeneIP for patents involving DUSP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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