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Aliases for DUSP18 Gene

Aliases for DUSP18 Gene

  • Dual Specificity Phosphatase 18 2 3
  • Low Molecular Weight Dual Specificity Phosphatase 20 3 4
  • LMWDSP20 3 4
  • Dual Specificity Protein Phosphatase 18 3
  • EC 4
  • EC 4
  • LMW-DSP20 4
  • DUSP20 3
  • DSP18 3

External Ids for DUSP18 Gene

Previous GeneCards Identifiers for DUSP18 Gene

  • GC22M027744
  • GC22M029372
  • GC22M029382
  • GC22M031048
  • GC22M014021

Summaries for DUSP18 Gene

Entrez Gene Summary for DUSP18 Gene

  • Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

GeneCards Summary for DUSP18 Gene

DUSP18 (Dual Specificity Phosphatase 18) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot for DUSP18 Gene

  • Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP)

Gene Wiki entry for DUSP18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DUSP18 Gene

Genomics for DUSP18 Gene

Regulatory Elements for DUSP18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DUSP18 Gene

30,652,051 bp from pter
30,667,890 bp from pter
15,840 bases
Minus strand

Genomic View for DUSP18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DUSP18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DUSP18 Gene

Proteins for DUSP18 Gene

  • Protein details for DUSP18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity protein phosphatase 18
    Protein Accession:
    Secondary Accessions:
    • B3KPA4

    Protein attributes for DUSP18 Gene

    188 amino acids
    Molecular mass:
    21066 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DUSP18 Gene

neXtProt entry for DUSP18 Gene

Proteomics data for DUSP18 Gene at MOPED

Post-translational modifications for DUSP18 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for DUSP18 Gene

Domains for DUSP18 Gene

Gene Families for DUSP18 Gene

  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Suggested Antigen Peptide Sequences for DUSP18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NEJ0
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
genes like me logo Genes that share domains with DUSP18: view

Function for DUSP18 Gene

Molecular function for DUSP18 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0. {ECO:0000269 PubMed:12591617}; Temperature dependence: Optimum temperature is 55 degrees Celsius. {ECO:0000269 PubMed:12591617};
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by manganese ions, inhibited by iodoaretic acid
UniProtKB/Swiss-Prot Function:
Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP)

Enzyme Numbers (IUBMB) for DUSP18 Gene

Gene Ontology (GO) - Molecular Function for DUSP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IDA 12408986
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
GO:0016791 phosphatase activity --
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with DUSP18: view
genes like me logo Genes that share phenotypes with DUSP18: view

Animal Model Products

miRNA for DUSP18 Gene

miRTarBase miRNAs that target DUSP18

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DUSP18 Gene

Localization for DUSP18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DUSP18 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DUSP18 Gene COMPARTMENTS Subcellular localization image for DUSP18 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DUSP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12408986
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 12408986
genes like me logo Genes that share ontologies with DUSP18: view

Pathways for DUSP18 Gene

SuperPathways for DUSP18 Gene

No Data Available

Interacting Proteins for DUSP18 Gene

Gene Ontology (GO) - Biological Process for DUSP18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation IDA 12408986
genes like me logo Genes that share ontologies with DUSP18: view

No data available for Pathways by source for DUSP18 Gene

Compounds for DUSP18 Gene

(4) HMDB Compounds for DUSP18 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • manganese
  • NFB Orthophosphate
  • Dihydrogen oxide
genes like me logo Genes that share compounds with DUSP18: view

Transcripts for DUSP18 Gene

Unigene Clusters for DUSP18 Gene

Dual specificity phosphatase 18:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DUSP18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DUSP18 Gene

No ASD Table

Relevant External Links for DUSP18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DUSP18 Gene

mRNA expression in normal human tissues for DUSP18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DUSP18 Gene

This gene is overexpressed in Testis (6.6) and Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DUSP18 Gene

SOURCE GeneReport for Unigene cluster for DUSP18 Gene Hs.517544

mRNA Expression by UniProt/SwissProt for DUSP18 Gene

Tissue specificity: Widely expressed with highest levels in liver, brain, ovary and testis.
genes like me logo Genes that share expressions with DUSP18: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for DUSP18 Gene

Orthologs for DUSP18 Gene

This gene was present in the common ancestor of animals.

Orthologs for DUSP18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DUSP18 35
  • 87.94 (n)
  • 91.49 (a)
DUSP18 36
  • 91 (a)
(Canis familiaris)
Mammalia DUSP18 35
  • 89.01 (n)
  • 94.15 (a)
DUSP18 36
  • 94 (a)
(Mus musculus)
Mammalia Dusp18 35
  • 82.45 (n)
  • 82.45 (a)
Dusp18 16
Dusp18 36
  • 82 (a)
(Pan troglodytes)
Mammalia DUSP18 35
  • 100 (n)
  • 100 (a)
DUSP18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dusp18 35
  • 84.22 (n)
  • 85.11 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
(Gallus gallus)
Aves DUSP18 35
  • 68.46 (n)
  • 64.07 (a)
-- 36
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dusp18 35
  • 57.36 (n)
  • 53.49 (a)
(Danio rerio)
Actinopterygii DUSP18 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15528 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea C04F12.8 36
  • 25 (a)
F13D11.3 36
  • 29 (a)
F26A3.4 36
  • 29 (a)
ZK757.2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10229 36
  • 45 (a)
Species with no ortholog for DUSP18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DUSP18 Gene

Gene Tree for DUSP18 (if available)
Gene Tree for DUSP18 (if available)

Paralogs for DUSP18 Gene

Selected SIMAP similar genes for DUSP18 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DUSP18: view

Variants for DUSP18 Gene

Sequence variations from dbSNP and Humsavar for DUSP18 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs8630 -- 30,662,128(-) CATCC(C/T)CATAA utr-variant-3-prime
rs1005887 -- 30,664,042(-) GCCTT(C/G)GTGCT utr-variant-5-prime
rs2240002 -- 30,663,263(+) AATCT(G/T)AAAAA utr-variant-3-prime, intron-variant
rs3067260 -- 30,662,051(+) ttttt(-/TT)ACACA downstream-variant-500B
rs4820893 -- 30,664,206(+) CAGAA(C/T)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DUSP18 Gene

Variant ID Type Subtype PubMed ID
nsv834175 CNV Gain 17160897

Relevant External Links for DUSP18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DUSP18 Gene

Disorders for DUSP18 Gene

Relevant External Links for DUSP18

Genetic Association Database (GAD)

No disorders were found for DUSP18 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DUSP18 Gene

Publications for DUSP18 Gene

  1. Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. (PMID: 16699184) Jeong D.G. … Kim S.J. (Acta Crystallogr. D 2006) 3 4 23
  2. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PMID: 12408986) Hood K.L. … Yoon C. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  3. Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. (PMID: 16720344) Wu Q. … Mao Y. (Front. Biosci. 2006) 3 23
  4. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. (PMID: 12591617) Wu Q. … Mao Y. (Biochim. Biophys. Acta 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DUSP18 Gene

Sources for DUSP18 Gene

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