Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DUSP18 Gene

protein-coding GIFtS: 47
GCID: GC22M031048

dual specificity phosphatase 18

Search for DUSP18
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dual Specificity Phosphatase 18¹ ²		DSP18²
DUSP20¹ ²		BK963H5.1¹
Low Molecular Weight Dual Specificity Phosphatase 20² ³		Dual Specificity Protein Phosphatase 18²
LMW-DSP20² ³		EC 3.1.3.16³
LMWDSP20² ³		EC 3.1.3.48³

External Ids:	HGNC: 18484¹	Entrez Gene: 150290²	Ensembl: ENSG00000167065⁷	OMIM: 611446⁵	UniProtKB: Q8NEJ0³

Export aliases for DUSP18 gene to outside databases

Previous GC identifers: GC22M027744 GC22M029372 GC22M029382 GC22M014021

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DUSP18:

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based

protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine

and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18

contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP

(mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009

(PubMed 19228121)).(supplied by OMIM, Dec 2009)

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0

Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the

phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate

(pNPP)

Gene Wiki entry for DUSP18

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DUSP18 gene promoter:
SRF NF-1 NF-1/L Pax-5 SRF (504 AA) Roaz C/EBPalpha Evi-1 CP2 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DUSP18 promoter sequence

Search SABiosciences Chromatin IP Primers for DUSP18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.1

DUSP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP18 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M031048: view genomic region (about GC identifiers)

Start:	31,048,038 bp from pter	End:	31,063,877 bp from pter
Size:	15,840 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0 (See protein sequence)

Recommended Name: Dual specificity protein phosphatase 18

Size: 188 amino acids; 21066 Da

Subcellular location: Cytoplasm. Nucleus

1 PDB 3D structure from and Proteopedia for DUSP18:

2ESB (3D)

Secondary accessions: B3KPA4

Explore the universe of human proteins at neXtProt for DUSP18: NX_Q8NEJ0

DUSP18 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689724.3

ENSEMBL proteins:

ENSP00000414825 ENSP00000385463 ENSP00000386063 ENSP00000366291 ENSP00000387680

ENSP00000384946 ENSP00000333917 ENSP00000340795 ENSP00000403378

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DUSP18 OriGene Protein Over-expression Lysate: DUSP18 OriGene Custom Protein Services for DUSP18
	GenScript Custom Purified and Recombinant Proteins Services for DUSP18
	Novus Biologicals DUSP18 Proteins Novus Biologicals DUSP18 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DUSP18
	Uscn Proteins for DUSP18

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12408986
GO:0005737	cytoplasm	IDA	12408986

DUSP18 for ontologies About GeneDecksing

DUSP18 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DUSP18
	GenScript Custom Superior Antibodies Services for DUSP18
	Novus Biologicals DUSP18 Antibodies
	Search for Antibodies for DUSP18 at Abcam
	Uscn Antibodies for DUSP18
	ThermoFisher Antibodies for DUSP18

Assay Products for DUSP18:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DUSP18
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DUSP18

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DUSP18 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000387 Tyr/Dual-sp_Pase

IPR020422 Dual-sp_phosphatase_subgr_cat

IPR016130 Tyr_Pase_AS

IPR020417 Atypical_DUSP

IPR024950 DUSP

Graphical View of Domain Structure for InterPro Entry Q8NEJ0

ProtoNet protein and cluster: Q8NEJ0

1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily

Similarity: Contains 1 tyrosine-protein phosphatase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0

Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the

phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate

(pNPP)

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Enzyme regulation: Activated by manganese ions, inhibited by iodoaretic acid

Biophysicochemical properties: pH dependence: Optimum pH is 6.0; Temperature dependence: Optimum temperature is 55

degrees Celsius;

Enzyme Numbers (IUBMB): EC 3.1.3.16¹ EC 3.1.3.48¹

miRNA Products:		OriGene 3'-UTR Clone: DUSP18 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP18
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP18:
		hsa-miR-452* hsa-miR-1322 hsa-miR-548aa hsa-miR-3125 hsa-miR-3916
		SwitchGear 3'UTR luciferase reporter plasmid: DUSP18 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP18 (see all 7) OriGene siRNA: DUSP18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP18

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DUSP18

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP18 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DUSP18 (NM_152511)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP18
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP18

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DUSP18
		Search LifeMap BioReagents cell lines for DUSP18

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP18

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004725	protein tyrosine phosphatase activity	IDA	12408986
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IBA	--
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA	--

DUSP18 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for DUSP18:

Decreased TP53 protein express

Decreased focal adhesion (FA)

Elongated cells

Stronger migration

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DUSP18

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006470	protein dephosphorylation	--	--
GO:0035335	peptidyl-tyrosine dephosphorylation	IDA	12408986

DUSP18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DUSP18

4 HMDB Compounds for DUSP18 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Manganese	manganese	7439-96-5	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about DUSP18 / DUS18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DUSP18 gene:

NM_152511.3

Unigene Cluster for DUSP18:

Dual specificity phosphatase 18

Hs.517544 [show with all ESTs]

Unigene Representative Sequence: BC028724

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000430175 ENST00000404885 ENST00000407308(uc003aiu.3) ENST00000461301

ENST00000377087 ENST00000412865 ENST00000403268(uc010gwa.2) ENST00000334679(uc003aiw.1)

ENST00000342474 ENST00000442752

miRNA Products:		OriGene 3'-UTR Clone: DUSP18 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DUSP18
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate DUSP18:
		hsa-miR-452* hsa-miR-1322 hsa-miR-548aa hsa-miR-3125 hsa-miR-3916
		SwitchGear 3'UTR luciferase reporter plasmid: DUSP18 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP18 (see all 7) OriGene siRNA: DUSP18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP18

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP18 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DUSP18 (NM_152511)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP18
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP18

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DUSP18
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP18
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP18

Additional cDNA sequence:

AF461689.1 AF533017.1 AK025036.1 AK056074.1 BC004110.2 BC028724.1 BC030987.1 CR456406.1

5 DOTS entries:

DT.109710 DT.100750066 DT.95373433 DT.99954797 DT.95282389

24/83 AceView cDNA sequences (see all 83):

CD675112 BE670431 BE222374 AA393396 AI299221 AF533017 NM_152511 AI283262

AA634547 BX090660 BX279710 BM833888 BC030987 CR456406 BM759289 BU584603

AI699242 AA431991 BE222542 BM979376 AA356476 BG619206 AW205336 CD359958

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DUSP18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGATAGAC

About this image

DUSP18 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DUSP18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DUSP18

SOURCE GeneReport for Unigene cluster: Hs.517544

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0

Tissue specificity: Widely expressed with highest levels in liver, brain, ovary and testis

SABiosciences Custom PCR Arrays for DUSP18

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DUSP18
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP18
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP18

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP18

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DUSP18 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DUSP18¹	dual specificity phosphatase 18	68.46(n) 64.07(a)		417005 XM_415295.3 XP_415295.3
lizard (Anolis carolinensis)	Reptilia	--	--	62(a)	1 → many	GL343417.1(197291-197857)
zebrafish (Danio rerio)	Actinopterygii	zgc:153044⁶ CABZ01071036.1⁶ (see all 3)	--	46(a) 36(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	5(72402198-72404174) 2(43757513-43758022)
fruit fly (Drosophila melanogaster)	Insecta	CG15528⁶	--	32(a)	possible ortholog	3R(25874357-25877834)
worm (Caenorhabditis elegans)	Secernentea	F13D11.3⁶ C04F12.8⁶ (see all 3)	Protein C04F12.8 (see all 3)	26(a) 25(a) (see all 3)	possible ortholog possible ortholog (see all 3)	X(5804352-5805889) I(9697585-9699546)
thale cress (Arabidopsis thaliana)	eudicotyledons	DSPTP1E⁶	protein-tyrosine-phosphatase IBR5	16(a)	possible ortholog	2(1588360-1590166)
rice (Oryza sativa)	Liliopsida	-- --	dual specificity protein phosphatase, putative, ex... dual specificity protein phosphatase, putative, ex...	14(a) 14(a)	possible ortholog possible ortholog	2(29876197-29879380) 6(11683181-11686916)

ENSEMBL Gene Tree for DUSP18 (if available)
TreeFam Gene Tree for DUSP18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DUSP18 gene

DUSP21² DUSP4² SSH2² DUSP10² DUSP6² DUSP19² DUSP14² DUSP28²

DUSP8² DUSP7² DUSP5² SSH3² DUSP16² DUSP9² DUSP2² SSH1²

DUSP1²

13 SIMAP similar genes for DUSP18 using alignment to 5 protein entries: DUS18_HUMAN (see all proteins):

DUSP21 DUSP14 DUSP19 DUSP10 DUSP13 DUSP8

DUSP16 DUSP15 DUSP3 DUSP7 DUSP22 DUSP28

DUSP9

DUSP18 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9609037^1,2	C,	--	31057584(+)	`GCACCT/CAGCTG`	1	--	ds500¹		3		NA	6
rs11325761^1,2	C,	--	31057590(+)	`AGCTG-/TTAAAA`	1	--	ds500¹		0	--	--	--	--
rs76352804^1,2	F,	--	31057695(+)	`CTCTGG/CATCAG`	1	--	ds500¹		1		WA	118
rs181701741^1,2		--	31057697(+)	`CTGGAC/TCAGAA`	1	--	ds500¹		0	--	--	--	--
rs141040023^1,2		--	31057741(+)	`AGGATA/GTGAAC`	1	--	ds500¹		0	--	--	--	--
rs186145267^1,2		--	31057801(+)	`GACACA/GGCCCC`	1	--	ds500¹		0	--	--	--	--
rs116386177^1,2	F,	--	31057830(+)	`CAGCCG/AGGGTG`	1	--	ds500¹		1		WA	118
rs144406312^1,2	C,	--	31057923(+)	`CAGGA-/CCTC TAGATTGCACC`	1	--	ds500¹		0	--	--	--	--
rs190122162^1,2		--	31057988(+)	`CTCCTA/GTGAGG`	1	--	ds500¹		0	--	--	--	--
rs3067260^1,2	C	--	31058018(+)	`tttttTT/-ttttt`	1	--	ds500¹		1		NA	2

HapMap Linkage Disequilibrium report for DUSP18 (31048038 - 31063877 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DUSP18: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP18

DNA2.0 Custom Variant and Variant Library Synthesis for DUSP18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DUSP18 for disorders About MalaCards

DUSP18 for disorders About GeneDecksing

OMIM gene information: 611446 OMIM disorders: --

Export disorders for DUSP18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DUSP18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DUSP18)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PubMed id 12408986)^{1, 2, 3} Hood K.L.... Yoon C. (2002)
Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. (PubMed id 16699184)^{1, 2, 9} Jeong D.G....Kim S.J. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. (PubMed id 12591617)^{1, 2} Wu Q.... Mao Y. (2003)
Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. (PubMed id 16720344)^{1, 9} Wu Q....Mao Y. (2006)
Dual-specificity phosphatases: critical regulators with diverse cellular targets. (PubMed id 19228121)¹ Patterson K.I....Daly R.J. (2009)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 150290	HGNC: 18484	AceView: DUSP18	Ensembl:ENSG00000167065	euGenes: HUgn150290
ECgene: DUSP18	H-InvDB: DUSP18

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DUSP18	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DUSP18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DUSP18 gene:
Search GeneIP for patents involving DUSP18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DUSP18		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DUSP18
	OriGene Protein Over-expression Lysate for DUSP18		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DUSP18		OriGene 3'-UTR Clone for DUSP18
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP18		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DUSP18
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for DUSP18		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DUSP18		OriGene Custom Protein Services for DUSP18
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DUSP18
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DUSP18
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DUSP18
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DUSP18
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DUSP18
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DUSP18

	GenScript Custom Purified and Recombinant Proteins Services for DUSP18		GenScript cDNA clones with any tag delivered in your preferred vector for DUSP18
	GenScript Custom Assay Services for DUSP18		GenScript Custom Superior Antibodies Services for DUSP18
	GenScript Custom overexpressing Cell Line Services for DUSP18		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DUSP18 promoter
	Search Chromatin IP Primers for DUSP18
	RT² qPCR Primer Assay in human, mouse, rat DUSP18
	Search GNC Networks for DUSP18
	SABiosciences Custom PCR Arrays for DUSP18

Search Tocris compounds for DUSP18

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DUSP18 antibodies
	DUSP18 proteins
	DUSP18 lysates

	Search for Antibodies for DUSP18 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for DUSP18
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for DUSP18

DUSP18 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DUSP18

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DUSP18

	SwitchGear 3'UTR luciferase reporter plasmids for DUSP18
	SwitchGear Promoter luciferase reporter plasmids for DUSP18

ThermoFisher Antibodies for DUSP18

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP18

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DUSP18 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DUSP18 Gene

dual specificity phosphatase 18

Aliases
for DUSP18 gene

Summaries
for DUSP18 gene

Genomic Views
for DUSP18 gene

Proteins
for DUSP18 gene

Protein Domains /
Families
for DUSP18 gene

Function
for DUSP18 gene

Pathways & Interactions
for DUSP18 gene

Drugs & Compounds
for DUSP18 gene

Transcripts
for DUSP18 gene

Expression
for DUSP18 gene

Orthologs
for DUSP18 gene

Paralogs
for DUSP18 gene

Genomic Variants
for DUSP18 gene

Disorders / Diseases
for DUSP18 gene

Publications
for DUSP18 gene

External Searches for DUSP18 gene

Genome Databases showing DUSP18 gene

Other Databases showing DUSP18 gene

Specialized Databases showing DUSP18 gene

Intellectual Property
for DUSP18 gene

Products
for DUSP18 gene

View Random Gene

Advanced Search

Export list of displayed genes

DUSP18 Gene

dual specificity phosphatase 18

Aliasesfor DUSP18 gene

Summariesfor DUSP18 gene

Genomic Viewsfor DUSP18 gene

Proteinsfor DUSP18 gene

Protein Domains /Familiesfor DUSP18 gene

Functionfor DUSP18 gene

Pathways & Interactionsfor DUSP18 gene

Drugs & Compoundsfor DUSP18 gene

Transcriptsfor DUSP18 gene

Expression for DUSP18 gene

Orthologsfor DUSP18 gene

Paralogsfor DUSP18 gene

Genomic Variantsfor DUSP18 gene

Disorders / Diseasesfor DUSP18 gene

Publicationsfor DUSP18 gene

External Searches for DUSP18 gene

Genome Databases showing DUSP18 gene

Other Databases showing DUSP18 gene

Specialized Databases showing DUSP18 gene

Intellectual Propertyfor DUSP18 gene

Productsfor DUSP18 gene

View Random Gene

Aliases
for DUSP18 gene

Summaries
for DUSP18 gene

Genomic Views
for DUSP18 gene

Proteins
for DUSP18 gene

Protein Domains /
Families
for DUSP18 gene

Function
for DUSP18 gene

Pathways & Interactions
for DUSP18 gene

Drugs & Compounds
for DUSP18 gene

Transcripts
for DUSP18 gene

Expression
for DUSP18 gene

Orthologs
for DUSP18 gene

Paralogs
for DUSP18 gene

Genomic Variants
for DUSP18 gene

Disorders / Diseases
for DUSP18 gene

Publications
for DUSP18 gene

Intellectual Property
for DUSP18 gene

Products
for DUSP18 gene