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DUSP18 Gene

protein-coding   GIFtS: 52
GCID: GC22M031048

Dual Specificity Phosphatase 18

  Search for DUSP18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dual Specificity Phosphatase 181 2     DUSP202
Low Molecular Weight Dual Specificity Phosphatase 202 3     bK963H5.12
LMW-DSP202 3     Dual Specificity Protein Phosphatase 182
LMWDSP202 3     EC 3.1.3.163
DSP182     EC 3.1.3.483

External Ids:    HGNC: 184841   Entrez Gene: 1502902   Ensembl: ENSG000001670657   OMIM: 6114465   UniProtKB: Q8NEJ03   
ORGUL members:         

Export aliases for DUSP18 gene to outside databases

Previous GC identifers: GC22M027744 GC22M029372 GC22M029382 GC22M014021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DUSP18 Gene:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based
protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both
tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling
pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain
found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by
Patterson et al., 2009 (PubMed 19228121)).(supplied by OMIM, Dec 2009)

GeneCards Summary for DUSP18 Gene:
DUSP18 (dual specificity phosphatase 18) is a protein-coding gene. GO annotations related to this gene include MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP26.

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0
Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the
phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl
phosphate (pNPP)

Gene Wiki entry for DUSP18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DUSP18 gene promoter:
         SRF   NF-1   NF-1/L   Pax-5   SRF (504 AA)   Roaz   C/EBPalpha   Evi-1   CP2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDUSP18 promoter sequence
   Search Chromatin IP Primers for DUSP18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DUSP18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.1

DUSP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DUSP18 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M031048:  view genomic region     (about GC identifiers)

Start:
31,048,038 bp from pter      End:
31,063,877 bp from pter
Size:
15,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase 18  
Size: 188 amino acids; 21066 Da
1 PDB 3D structure from and Proteopedia for DUSP18:
2ESB (3D)    
Secondary accessions: B3KPA4

Explore the universe of human proteins at neXtProt for DUSP18: NX_Q8NEJ0

Explore proteomics data for DUSP18 at MOPED


See DUSP18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689724.3  
ENSEMBL proteins: 
 ENSP00000414825   ENSP00000385463   ENSP00000386063   ENSP00000366291   ENSP00000387680  
 ENSP00000384946   ENSP00000333917   ENSP00000340795   ENSP00000403378  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

Selected InterPro protein domains (see all 7):
 IPR000387 Tyr/Dual-sp_Pase
 IPR020422 Dual-sp_phosphatase_subgr_cat
 IPR016130 Tyr_Pase_AS
 IPR020417 Atypical_DUSP
 IPR024950 DUSP

Graphical View of Domain Structure for InterPro Entry Q8NEJ0

ProtoNet protein and cluster: Q8NEJ0

1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain


Find genes that share domains with DUSP18           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DUS18_HUMAN, Q8NEJ0
Function: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the
phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl
phosphate (pNPP)
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Enzyme regulation: Activated by manganese ions, inhibited by iodoaretic acid
Biophysicochemical properties: pH dependence: Optimum pH is 6.0; Temperature dependence: Optimum temperature is 55
degrees Celsius;

     Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004725protein tyrosine phosphatase activity IDA12408986
GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
GO:0016791phosphatase activity ----
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity IEA--
     
Find genes that share ontologies with DUSP18           About GenesLikeMe


Phenotypes:
     4 GenomeRNAi human phenotypes for DUSP18:
 Decreased TP53 protein express  Decreased focal adhesion (FA)   Elongated cells  Stronger migration 

Animal Models:
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miRNA
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miRTarBase miRNAs that target DUSP18:
hsa-mir-744-5p (MIRT037689), hsa-mir-218-5p (MIRT024249)

Block miRNA regulation of human, mouse, rat DUSP18 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate DUSP18:
hsa-miR-452* hsa-miR-1322 hsa-miR-548aa hsa-miR-3125 hsa-miR-3916
SwitchGear 3'UTR luciferase reporter plasmidDUSP18 3' UTR sequence
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP18

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DUS18_HUMAN, Q8NEJ0: Cytoplasm. Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol3
mitochondrion2
extracellular1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005730NOT nucleolus IDA--
GO:0005737cytoplasm IDA12408986

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DUSP18
Interactions:

    Search GeneGlobe Interaction Network for DUSP18

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for DUSP18 (ENSP000003339174) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PPP2R2BENSP000003365914STRING: ENSP00000336591
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006470protein dephosphorylation ----
GO:0016311dephosphorylation ----
GO:0035335peptidyl-tyrosine dephosphorylation IDA12408986

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DUSP18 (DUS18)

4 HMDB Compounds for DUSP18    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
Manganesemanganese 7439-96-5--
PhosphateNFB Orthophosphate (see all 13)14265-44-2--
WaterDihydrogen oxide (see all 2)7732-18-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DUSP18 gene: 
NM_152511.3  

Unigene Cluster for DUSP18:

Dual specificity phosphatase 18
Hs.517544  [show with all ESTs]
Unigene Representative Sequence: BC028724
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000430175 ENST00000404885 ENST00000407308(uc003aiu.3) ENST00000461301
ENST00000377087 ENST00000412865 ENST00000403268(uc010gwa.2) ENST00000334679(uc003aiw.1)
ENST00000342474 ENST00000442752
miRNA
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5 qRT-PCR Assays for microRNAs that regulate DUSP18:
hsa-miR-452* hsa-miR-1322 hsa-miR-548aa hsa-miR-3125 hsa-miR-3916
SwitchGear 3'UTR luciferase reporter plasmidDUSP18 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: DUSP18 (NM_152511)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DUSP18
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DUSP18
Primer
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OriGene qPCR primer pairs and template standards for DUSP18
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DUSP18
  QuantiTect SYBR Green Assays in human, mouse, rat DUSP18
  QuantiFast Probe-based Assays in human, mouse, rat DUSP18

Additional mRNA sequence: 

AF461689.1 AF533017.1 AK025036.1 AK056074.1 BC004110.2 BC028724.1 BC030987.1 CR456406.1 

5 DOTS entries:

DT.109710  DT.100750066  DT.95373433  DT.99954797  DT.95282389 

Selected AceView cDNA sequences (see all 83):

BE222374 AA431991 BE670431 AI699242 BX279710 AA634547 NM_152511 AF533017 
BM833888 CR456406 BC030987 AI283262 AI299221 BX090660 AA393396 CD675112 
BM759289 BU584603 BE222542 AK025036 AL711163 BU584240 AA631561 AA356476 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DUSP18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGATAGAC
DUSP18 Expression
About this image


DUSP18 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Liver (Hepatobiliary System)
         Hepatocytes Liver Lobule
DUSP18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DUSP18 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.517544

UniProtKB/Swiss-Prot: DUS18_HUMAN, Q8NEJ0
Tissue specificity: Widely expressed with highest levels in liver, brain, ovary and testis

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DUSP18 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dusp181 , 5 dual specificity phosphatase 181, 5 82.45(n)1
82.45(a)1
  11 (2.74 cM)5
752191  NM_173745.51  NP_776106.11 
 38952405 
chicken
(Gallus gallus)
Aves DUSP181 dual specificity phosphatase 18 68.46(n)
64.07(a)
  417005  XM_415295.4  XP_415295.4 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
63(a)
1 → many
GL343417.1(197291-197857)
tropical clawed frog
(Xenopus tropicalis)
Amphibia dusp181 dual specificity phosphatase 18 57.36(n)
53.49(a)
  100491030  XM_002931705.2  XP_002931751.1 
zebrafish
(Danio rerio)
Actinopterygii DUSP186
dual specificity phosphatase 18
47(a)
1 → many
5(72402198-72404174) ENSDARG00000067564
fruit fly
(Drosophila melanogaster)
Insecta CG155286
--
36(a)
1 → many
3R(25874357-25877834)
worm
(Caenorhabditis elegans)
Secernentea F26A3.46
F13D11.36
(see all 4)
Protein F13D11.3 (F13D11.3) mRNA, complete cds
(see all 4)
29(a)
29(a)
(see all 4)
many ↔ many
many ↔ many
(see all 4)
I(7656907-7658291) WBGene00009142
X(5804387-5805922) WBGene00017428


ENSEMBL Gene Tree for DUSP18 (if available)
TreeFam Gene Tree for DUSP18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DUSP18 gene
DUSP262  DUSP212  DUPD12  DUSP32  DUSP132  DUSP272  STYX2  DUSP142  
DUSP192  DUSP282  DUSP152  DUSP222  
12 SIMAP similar genes for DUSP18 using alignment to 5 protein entries:     DUS18_HUMAN (see all proteins):
DUSP21    DUSP14    DUSP19    DUSP10    DUSP13    DUSP8
DUSP16    DUSP15    DUSP3    DUSP7    DUSP22    DUSP28

Find genes that share paralogs with DUSP18           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DUSP18 (see all 210)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs96090371,2
C--31057584(+) gcaccT/CAGCTG 1 -- ds50013Minor allele frequency- C:0.17NA 6
rs113257611,2
C--31057590(+) AGCTG-/TTAAAA 1 -- ds50010--------
rs763528041,2
F--31057695(+) CTCTGG/CATCAG 1 -- ds50011Minor allele frequency- C:0.04WA 118
rs1817017411,2
C--31057697(+) CTGGAC/TCAGAA 1 -- ds50010--------
rs1410400231,2
C--31057741(+) AGGATA/GTGAAC 1 -- ds50010--------
rs1861452671,2
--31057801(+) GACACA/GGCCCC 1 -- ds50010--------
rs1163861771,2
F--31057830(+) CAGCCG/AGGGTG 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1444063121,2
C--31057923(+) CAGGA-/CCTC  
  TAGATT
GCACC
1 -- ds50010--------
rs1901221621,2
--31057988(+) CTCCTA/GTGAGG 1 -- ds50010--------
rs86301,2
C,F,A,H--31058115(-) CATCCT/CCATAA 1 -- ut31 ese331Minor allele frequency- C:0.37MN NS EA NA WA CSA 3401

HapMap Linkage Disequilibrium report for DUSP18 (31048038 - 31063877 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for DUSP18:    About this table    
Variant IDTypeSubtypePubMed ID
nsv834175CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DUSP18
DNA2.0 Custom Variant and Variant Library Synthesis for DUSP18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611446    OMIM disorders: --


Find genes that share disorders with DUSP18           About GenesLikeMe

Genetic Association Database (GAD): DUSP18

Export disorders for DUSP18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DUSP18 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with DUSP18)
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  1. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. (PubMed id 12408986)1, 2, 3 Hood K.L.... Yoon C. (Biochem. Biophys. Res. Commun. 2002)
  2. Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. (PubMed id 16699184)1, 2, 9 Jeong D.G....Kim S.J. (Acta Crystallogr. D 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  6. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. (PubMed id 12591617)1, 2 Wu Q.... Mao Y. (Biochim. Biophys. Acta 2003)
  7. Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. (PubMed id 16720344)1, 9 Wu Q....Mao Y. (Front. Biosci. 2006)
  8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  9. Dual-specificity phosphatases: critical regulators with diverse cellular targets. (PubMed id 19228121)1 Patterson K.I....Daly R.J. (Biochem. J. 2009)
  10. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. (PubMed id 17434096)4 MatarA-n M....Meschia J.F. (Lancet Neurol 2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 150290 HGNC: 18484 AceView: DUSP18 Ensembl:ENSG00000167065 euGenes: HUgn150290
ECgene: DUSP18 H-InvDB: DUSP18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DUSP18 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DUSP18 gene:
Search GeneIP for patents involving DUSP18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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